Metabolism | Gluconeogenesis
ฝัง
- เผยแพร่เมื่อ 29 พ.ค. 2017
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will present on gluconeogenesis. We discuss how we convert amino acids, glycerol, lactic acid, and odd chain fatty acids into glucose, as well as the various enzymes involved with regulating this pathway. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #Gluconeogenesis #Metabolism
Moral of the gluconeogenesis story : don't give up, find some another way to get around the obstacle 😊
Every thing is possible for a willing heart
Shinzoo Wallace I think he meant literally 😂
LOL amazing
✌️
@@oscarwong4201 😂😂
This stuff is legit incredible. I had a lecture on this at university, and my professor was so terrible at explaining both glycolisis and gluconeogenesis. She just showed slides of the entire cycle and talked about the steps by laserpointing at them. It was two hours of torture. I love how you showed it step by step. This is the way.
Thanks for being in the community! - TG
Same
@@NinjaNerdOfficial I LOVE YOU T_T
same dude, i share your pain
Same
Honestly, i dont know why i'm paying my medical school a hand and a foot when you're the actual person teaching me. You're a gift from God. THANK YOU!!!!!!!!!!!!!!!!!!!
In my country we pay a lot only to get confused and write exams, they don't care whether or not you come for lessons as long as you pay and write tests you're all good
Wow
Fr
@@lerathomukela6335 sameeee
@@lerathomukela6335
may i ask, where are you from?
give this guy a nobel prize pleeeeeeeeeaaaseee
saving my medical school
I agree! :)
Alaa al yeahh me too:)
I agree you too
100% damn true
goddamit you are right
Bio-medical science student here, wanted to thank you so so much! I've been struggling with this course throughout the semester, up until the point of completely giving up, not showing up on lectures nor submitting assignments. Now with the test coming up I've watched the entire playlist like 5 times, and it's such a different experience! I found out I actually kinda like it! No professor in the world could help me out the way you guys at ninja nerd did.
THANK YOU FOR EVERYTHING YOU'RE DOING, YOU HAVE NO IDEA HOW MANY STUDENTS YOU'VE HELPED! saved my degree 100%!
The liking it part, was amazing 🤩
This is awesome. Current struggling medical student here and your vids have been a lifesaver!
Wow, I was literally telling myself that I was stupid af because I couldnt remember an enzyme. This somewhat cheered me up.
Christien Pena what year ?
It's hard to understand why it's commonly thought that diabetic ketoacidosis could be caused by nutritional ketosis in healthy or non-diabetic people. Even more so that the brain "prefers" glucose over ketones simply because it uses glucose until it's exhausted the supply. Why is it not considered the bodies way of eliminating what we know as a toxic substance to get back into homeostasis? Does the body require carbohydrates (i.e., SUGAR)? NO! There is no such thing as an essential carbohydrate, unlike the fact that there are (Almost all) essential amino acids derived from bioavailable nutrient-dense animal sources unlike the non-bioavailable plant sources due to the oxalates, phytates, and numerous other plant defense compounds that cause diabetes including the aptly named type 3 diabetes ergo Alzheimer's and dementia. Likely caused by the overconsumption of carbohydrates. Is it any wonder that when the body requires a small amount of glucose for its requirements that the liver performs the process we know as gluconeogenesis? Why is it that sugar stimulates the same part of the (pleasure center) brain that cocaine and heroine do? Are they preferred by the brain as well?
I'm a fan of the ninja's here, but the non-scientific remarks lend to oversimplification, which simply is not true. Let's suppose for the sake of argument that we look at the diabetics condition regarding the so-called preferred fuel (currently conventional hypothesis). Type1 diabetics are more susceptible to ketoacidosis than type 2 and as we reduce the severity down further to pre-diabetic and insulin resistant the risk is reduced likewise. Today we are likely to see 1 in 3 people with one of these conditions or at least other conditions like obesity, CHD and so on. In the '60s and 70's not so much. Conventional thinking, in other words, is not thinking, it's just groupthink. And the reason learned doctors bought into the hypothesis that cholesterol was bad from horrible pseudoscience that led to Statins, then ED medication, Metformin and the like. So now they manage diseases for profit rather than prescribe the means to cure, prevent and reverse said conditions. Do you know that it's still taught that type2 diabetes is a progressive disease when thousands of people have been diagnosed with it, then changed their diet or took up a fasting focused lifestyle and reversed it thereby curing it by definition. How bout, Fatty Liver disease or non-alcoholic fatty liver disease said to be no cure for it and yet numerous people likely anyone 30 to 40lbs overweight or eating lots of fructose (more carbs like fruit) or drinking soda ridding themselves of the diagnosis after ceasing the practice of partaking in the consumption of the so-called preferred fuel. And that's without exercise. Does the brain take-up lactate as a fuel like the heart that seems to prefer it. According to Dr. George A. Brooks research, it would appear that his lactate shuttle theory is spot on and has been a pioneer for decades over all the conventional textbooks regurgitating conventional outdated ideas. Remember, plant agriculture is so very young in human history(12 thousand years at best), which is not to say it has no place in the human diet. That being said however what is the human digestive system designed to process the best for optimal nutrition? Is it the human cells that process and take up the carbs from plant matter, or the bacteria from the gut microbiome which are located in a healthy gut after the stomach (Ph of 1.5 to 2, consisting of hydrochloric acid and pepsin) some in the duodenum but mostly in the colin where that matter ferments (rots) gets excreted by the bacteria (pooped out) as short-chain fatty acids only then available as a source of energy? And what are HCI and pepsin in the stomach to do but break down protein from animal sources like all predators? Ever wonder why you don't see meat in your own excrement, but corn, legumes and the like often enough.
Sorry for the rant, but as I said I like the nerds and their presentation in particular, however, I suppose to pass an exam taught at universities that conform to bought and paid for by pharmaceutical, Coke and big food/agriculture and pesticide industries you would go further in academia than questioning bogus studies paid for by the same. Ever wonder why so many vegans suffer neurological disorders or a malnourished appearance and please don't quote the propaganda film game-changers, please.
Anyway check out why to your body the no such thing as a calorie and counting them is ridiculously absurd, Gnolls.org
Enjoy
@@rogerowen8143 stfu roger
@@shmed6432 hey, thats just plain rude.
You should be a med school professor
He is better than 90% of the professors I've ever had
@@baharfadaee 100% of mine XD
@@baharfadaee🍎, 🎈♟️hub daft u0nj7x e, 🍊8x🚾⬆️xj🤩🎈m
He is a professor
The passionate desire to teach and explain the micro processes of organic life is extraordinary. To humbly acknowledge and be wowed by the divinity of life @12:47 is even greater!
12:48 "Thankfully, God has provided another enzyme"
My eyes rolled hard.
@@taungchild and I was really proud of that part.
lmaooo I just got to that part like what 😭
@@taungchild cry
You're not just helping me to understand biochemistry, I'm actually in love with it because of you !
I am not a med student - I'm just a 63 year old guy interested in interment fasting and how it works. I started to watch videos on this gluconeogenesis process and was stunned at the complexity. I though, "how could anyone remember this?!" But this one was so awesome it drew me in to continue listening to the explanation and to watch it again. I saw one video where another guy said, "3 or 4 enzymes were specially evolved for this process..." I thought, "is he crazy? That's not possible - it just happened?!" Anyhow, when you said, "God has provided another enzyme." It warmed my heart and made my day. Is it Zach? Thanks and whatever your name is, God Bless you. If there is no God - life doesn't mean a damn thing.
You have no idea how many med student lives youre saving through these awesome videos. Thank you!
Thank you alot. The way you simplified the process plus the drawing on the board is sure to help me remember. Please keep up the good work and more videos!
Thank you so much for those kind words and i'm glad it helped!!! More videos coming your way haha!! Take care!
@Raghad yh, that's very necessary
You technically discussed a whole semester long of lectures in just a few vids. Thank u so much and God bless your channel 💯
i feel like I’m making gluconeogenesis as I’m watching this video😂
Subhan Allah this is really cool
your lecturing and teaching abilities are literally unbelievable, you are the best science channel on youtube
i never liked video tutorials,but the ninja nerd changed my mind. very simple to conceptualise,yet filled with everything i need. thank you
One of the best teachers I've ever seen! How have I just come across this in the last two weeks? Amazing!
Great video. I really like how you kept the big picture in mind the whole time. Thank you!
+Ally Keathley Thanks Ally! Keep on watching!
I'm taking the MCAT in 4 weeks and have been so behind on content review. I just wanted to say this video made learning the process SO MUCH easier. I found reading the book wasn't helping me learn as fast and with this video I had this concept down within 30 minutes. THANK YOU!!
I am so glad I found your videos. Currently really struggling with biochem and your videos JUST MAKE SENSE! Thank you so much!
this channel is pure gold. I love the way you speak informal yet so detailed
You're a great teacher. I'm appreciating these videos a lot!
Thank you for this video! I’ve been struggling through this material, but you’ve helped make much more sense out of it!
These are the best lectures I’ve ever heard, I wish I had these resources when I was in med school, you made my life easier thank you 🙏🏻
You are the BEST lecturer ever!!! You're saving my uni life! No words to explain how thankful I am!!
12 weeks on this topic at uni and i left more confused than every, this guy 29mins and thousands of dollars cheaper n it clear as crystal finally all makes sense. Thank you sir, God bless you
You covered everything in this one video. Thank you, man
Literally a life SAVER!! 😭
Nicely explained thank you 💛
You explain all the topics perfectly. Thank you so much for helping millions of students like me.
Thank you for putting these pathways into the greater context. SOOOO helpful.
30min tutorial from you is better than spending 2h in the lecture theater in the Uni
Thank you so much for this video , I watched all of your biochem videos and yesterday I passed my biochem exam .
Thanks a lot
Thus channel is teaching me so much freaking info, and for the price of internet access.
Tech era has it's perks.
Studying for the MCAT and your videos have been a lifesaver for learning and truly understanding biochemical processes, especially the metabolic pathways. Thank you!!!!!
Very helpful to get a clear concept of the process...you made it super easy... Thank you so much.... Expecting many more concept clearing interesting videos from you👍👍
+Indu Lekshmi thank you so much for your kind words and I am so happy that we were able to help!
awesome way of explaining such complicated concept of gluconeogenesis into something easy to understand:) BIG THANKS!
SO much better than any other lectures I've seen on youtube!
you know that I missed metabolism classes cause I knew I will waste a tremendous amount of time with a teacher that doesn't explain very well, but now I know that I did the right thing thanks a lot ninja.
This map you created is literally perfect! Also your analysis was so smooth it felt like listening to a storytelling
periodt
THANK YOU THANK YOU THANK YOU! You just taught me in 29min what I couldn't understand from 3 1hr lectures! THANK YOU!
Omg this is so truuuee3ee
I remember when this channel had like a few k views per video at most. I'm so glad it finally started to grow!
Thanks man, you've explained in 30 minutes what I've tried to understand in years
This metabolism series is definitely a lifesaver!!
Very well explained..Please introduce yourself ..Your good name..And all your videos have been highly helpful for me to overcome my phobia in biochemistry!Blessings from India!
Maybe we can do a video introducing the whole team one day!? Thanks so much!
I over heard a girl mentioning this channel in college . I'm from Pakistan btw . Respect for providing such quality of education for free . (:
deepika ramanjan
@@NinjaNerdOfficial yes please! thank you for all your efforts!!!!!!
God bless u sir
I had such a happy moment when you did a couple pauses and I correctly recalled specific stuff you taught in previous videos! Thank you so much for the great lessons as they prove to be useful!
You literally simplified it well, please keep up the good work and thankyou so much.
Thank you so much man, you're my new favorite person!! Literally helped me understand before my clinical biochemistry exam.
+Levy Redfox Awesome! So glad to help!
Wow! Thank you for helping us!
I have so much respect for this guy, i hope you will make millions of dollars, because you are helping so many people (students) with your videos and i really appreciate the time that you put into those videos
You're doing such a great work, helping us struggle with biochemistry! Greetings from a Ninja Nerd from Poland!
Thank you so much for this great video! You really simplified the process in a way that I can easily understand! Keep it up!
+Jimmy Shaw I'm so happy you enjoyed it and I'm so glad it helped!!
What makes me love watching your videos the most is your smile while explaining and your passion for biochemistry. I really love this field and I will enter the International biology bowl this year with my nice team you helped me a lot in understanding Biochemistry. Keep going 💪
You have an incredible way of teaching! Cannot thank you enough for these videos you create!
literally the best video on gluconeogenesis i have watched. If your in biochemistry subscribe to this guy!
lol
I have just watched like 3 of the videos and i really wanna say a big thank you becuase i really understand, even though i was not listening in my biochemistry class
+Emerald Emerson Awesome!!!! I'm so happy we were able to help!!!
Thank you for your help with these metabolic processes. Could you gear future videos toward mcat prep?
Just had a online lecture. Found the teaching so boring and hard to understand, so I switched over to this channel and watched this video instead.
It's the best thing I could do to get an understanding of how this mechanism works.
Thank you very much for an incredible explanation! Wish all teachers were as good as explaining this stuff as you guys are!
You cleared all doubts in gluconeogenesis. You are amazing. Thank you
great
you're amazing
very helpful for me
thanks from the heart 💖
this was so helpful!
I was struggling understanding gluconeogenesis from other videos. Great job explaining the process! Thank you!
You really deserve a nobel prize..your videos have made med school interesting
Praised God for your lesson. Now I got it.
Thx a lot from France, the way u explain is so cool & adorable...hope I can compensate one day :) 🙏🏼
Thanks for your support. We do have a patreon account if you are ever in the position to help us out!
vic
Yes, I second that. Thank you so much. First time I've been able to absorb the process.
Im so blessed to have found this channel
I enjoy it ,you explaind it in great way ,you made it fun ,god bless 💙💚💛💜💖💕
+Immy Immy thank you so much for your kind words I'm so happy that we were able to help!
Hey! Thank you so much! I'm a med student and these biochemistry and anatomy videos really helped a lot! By the way, I was taught that some aminoacids could not be converted into glucose. Those were the ones that were converted into Acetyl-CoA. Why? Because we would have to use one molecule of OAA to react with the Acetyl-CoA and then we would get one OAA. So I guess those aminoacids cannot undergo the gluconeogenesis process. This is what i was taguht, but I'm not sure since you didn't mention it! Thanks again so much
+Andreia Filipa Lopes Sousa hello great question! Generally any amino acids specifically such as leucine, lysine and aromatic amino acids are converted to acetyl-CoA or acetoacetate. Due to this activity leucine, lysine, and aromatic amino acids are generally classified as ketogenic amino acids meaning they contribute to ketogenesis which is the formation of ketone bodies, however these same amino acids do have a very minor contribution to the Gluconeogenesis process!!! Hope that helps!!!
Ninja Nerd Science really informative, thank you so much! Keep up the great job!
@@andreiasousa9688 Good luck with all exams, you are gonna make it. We all believe in you
Wow, thank you for this really great explaining! I didn't understand the gluconeogensis so well before i found this video, but now i do, so thanks!
Congratulations! Excellent job. Your love for the subject comes through clearly. You provided me with a sorely needed refresher. I specifically needed a clarification as to potential contribution of fatty acids to GNG.
THANK YOU
you are literally my teacher i am not just watching this as a tutor or anything!!!thank you soooooooo much for all the hard work you put in making these videos. will do anything to promote the channel. just keep up the good woorkkkkkk.
This video was AMAZING. I wish all my professors took the time to teach this way for us visual learners. Your great at explaining...This is the video of yours I watched but I just subscribed to the channel!!!
You're actually making this understandable - and fun! You're a star. Thank you so much!
This dude explains the subject way better than my Advanced Biochemistry doctor
Thank you so much for this explanation! It was perhaps the best I've seen in my search to understand this amazing process of gluconeogenesis.
I have been doing a Keto way of eating for the last 3 years and I have lost 43 pounds and gained amazing health and all my markers are normal. In a keto context, the dietary carb restriction produces a change in the body that uses ketone bodies for fuel, and that includes the brain, whereas before carb restriction the brain was operating on glucose. However, the change is not to be feared as in the case of Type I Diabetes, where ketoacidosis is of major concern, as it should. The level of ketosis as measured in the blood of an individual who is adapted to burn fat as the main cell fuel is not at all in the danger area of ketoacidosis, as the level of ketosis in a keto context is at most around 5 milimolers. But since this is the energy the body is running on, often times the level is lower.
I do think though that the whole process is "wonderful[ly] and fearfully" designed by God and I am so thankful for His wisdom and for your great explanation. :)
I am a big fan of yours. Thanks for making biochemistry easy to understand for the first time. Just a doubt in this video the channel to go out of endoplasmic reticulum for glucose is T2or T3? Thanks again for every video.
The free phosphate exits via the T2 transporter; the glucose exits via the T3.
You're so amazing...really saved my life for having Biochemistry exam tomorrow!
Great! I am a podiatry medical student studying for my second biochem exam and this was so helpful! Thank you!
You are amazing 😍 thanks for you
+Semsem Mhamed you’re welcome!
Ninja Nerd Science keep on 😍
May Allah bless you , you're saving my grades :)
thank you so much finally I understand this process, all medical student need to see this :D
Ninja nerd has become my daily revision channel...keep up the work sir.. u're really splendid😊😊
"God has provided another enzyme."
C I T A T I O N N E E D E D ;)
@@kida4313 I caught that too and literally dropped my jaw lol. He sneaked that in so smoothly.
well now we know why he's not helping with evolutionary biology videos lol
Yikes.
I loved that sentence as well !!!!
'God has provided another enzyme'- it was at this point that I fell in love fully with these videos - Thank you for your knowledge, sharing and also most importantly acknowledging Who all of this complexity and beauty came from
Yes.
Zeus deserves much more more respect than he gets.
Bless Ninja 🙏🏻
some people are just born to teach. Brilliant! Thank you
Can i just say thank u??? As a visual learner, u’ve made this topic especially easy. Thank u so much! 🤘🏼
You gave me the strength I needed to take the next steps toward my dream , Thank you so much
12:48 😭❤️❤️
Indeed God is the greatest .
12:49
Amen
I came across this video and it is exactly what I needed. This guy makes biochemistry fun.. RESPECT🙌
Your way of teaching is awesome. I am totally dependent on your videos to clear my concepts and proffs!!!
When I heard you say "God has provided another enzyme" I almost came to tears. It's so refreshing to see someone give Glory to the Lord for His amazing creation. We are wonderfully and beautifully made. More complex than any human creation. We are not a result of random processes, but an intentional creator. God bless you in Jesus' name.
Our Lord bless him
Just stfu
English is my second language but you makes lectures as fluent as possible. Thanks a lot. 🌷
Realy, you are the most powerful doctors that I have ever seen like you
You are fantastic. You have helped me a great deal throughout my biochem courses. Thank you for what you do. God bless you.
That was so nicely explained, thank you a million
I've spent so much time watching your videos...thanks for taking the time to break it down!
You are just absolutely brilliant! A life saver for medicos and residents !
Thank you so much. I can’t thank you enough really, you helped me understand this so nicely . You’re a hero.
These are the only lecture I'm able to pay attention to and retain from for biochem!!!!