Metabolism | Regulation of Gluconeogenesis

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  • เผยแพร่เมื่อ 12 มิ.ย. 2017
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will be continuing our discussion on gluconeogenesis, where we go into more detail on the regulation of gluconeogenesis as well as the enzymes involved in this process. We hope you enjoy this lecture and be sure to support us below!
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    #ninjanerd #GluconeogenesisRegulation #Metabolism

ความคิดเห็น • 261

  • @renivp3208
    @renivp3208 10 หลายเดือนก่อน +51

    This man is single-handedly saving the grades of students taking biochem

  • @shayamorre2882
    @shayamorre2882 5 ปีที่แล้ว +275

    Who are you!? And why are you just so amazing? Please continue. I’m shouting you out at graduation!! Thank you for being a magical deliverer of the teachings of this once evil subject which is actually fun now.

  • @monarch3507
    @monarch3507 ปีที่แล้ว +53

    People don't realise how important public speaking skills are for a teacher... I have tried to watch the same topic elsewhere but fell asleep in the middle of the video... You just are amazing Prof...

  • @nero91
    @nero91 5 ปีที่แล้ว +90

    "one mor thing, to finish off" - Half the video left.
    JK'ing my friend, love your videos. Biochem exam in 2 days and you give me confidence.

  • @piyushsumera9076
    @piyushsumera9076 6 ปีที่แล้ว +187

    No matter ho much technology advances,The best way to study is by Classroom method and anyday the Erase board explanation will have edge over those fancy presentations..Because teacher can never get involved with the teaching by that premade presentations and You prove that again and again.
    You dont have an idea How many videos and sites I have browsed to go through this Tandem enzyme regulation..And You explained it ridiculously easily. Thanks a ton man !!!

    • @lailashoukat714
      @lailashoukat714 2 ปีที่แล้ว +1

      the best way is teaching on board and then showing gross pics through slides.

    • @signalrod2213
      @signalrod2213 2 ปีที่แล้ว +7

      but also only because of advanced technology this method works for many, the key difference is that you have the ability to pause or rewind, which you can't do irl in class

    • @praisehart7737
      @praisehart7737 ปีที่แล้ว

      @@signalrod2213 if more professors allowed students to take them back without making them feel bad that'll be the case in real life too

    • @signalrod2213
      @signalrod2213 ปีที่แล้ว

      @@praisehart7737 it's not exactly like that: putting myself in professors skin, how is it professors fault that I zoned out for 15 mins, and I don't feel like studying rn, I rather do it in 40 mins. You can't just listening to a lecture when you are tired of it and don't feel like you are accepting all the information, you can't just stop and look up some other topic, which you missed, and spend like 30 mins learning that first and then coming back to this one

    • @signalrod2213
      @signalrod2213 ปีที่แล้ว +1

      @@praisehart7737 it's subjective, but personally for me studying in class is 15 times less productive than on my own in front of a screen

  • @SilentEagle2029
    @SilentEagle2029 4 ปีที่แล้ว +117

    Biochem exam is in 36 hours, you have saved my life! Thank you!

    • @mehmetalitaspinar9938
      @mehmetalitaspinar9938 4 ปีที่แล้ว +2

      Mines too

    • @studybiology9673
      @studybiology9673 2 ปีที่แล้ว

      How was it?

    • @SilentEagle2029
      @SilentEagle2029 2 ปีที่แล้ว +15

      @@studybiology9673 This was 2 years ago, I am graduated now and passed Biochem with an A, but from what I remember, that exam went terribly lmao. But it would've been even worse without this video, so my original point still stands, this man is a life saver!

    • @studybiology9673
      @studybiology9673 2 ปีที่แล้ว +1

      @@SilentEagle2029 👍👍👍

    • @zzoldd
      @zzoldd ปีที่แล้ว +1

      @@SilentEagle2029 ooo congrats

  • @frajwggg1568
    @frajwggg1568 6 ปีที่แล้ว +82

    Man those videos should have a millions views

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  6 ปีที่แล้ว +15

      +Frajw Ggg Hopefully someday soon! Thank you so much!

    • @Outono937
      @Outono937 6 ปีที่แล้ว +4

      I strongly agree with you!!

  • @miriamwilliams9603
    @miriamwilliams9603 4 ปีที่แล้ว +49

    Dude, what's your day job? are you a doctor? professor? The One? Thank you for everything!!!

  • @JohnSnow-vg4tz
    @JohnSnow-vg4tz ปีที่แล้ว +2

    This was so intense, but it was worth watching. I watched it twice and understood the concept. Thank you, Zack!!!

  • @eggs8352
    @eggs8352 5 ปีที่แล้ว +19

    If I discovered your channel during my biochem class maybe I understood the subject better. I'm just here because I felt the need to review these pathways because this is heavily related to the subjects I have trouble understanding with :(
    Thank you sir for making such efforts to help students understand these complex subjects. Keep the passion burning. Salute to your team!

  • @Uds_Baduge
    @Uds_Baduge 5 ปีที่แล้ว +38

    You have no idea how much I love biochemistry now thanks to you!!! I used to HATE it with a passion before I found your videos!!!!! Thank you so much!!!!!!!!!!

    • @karinsedlakova6316
      @karinsedlakova6316 5 ปีที่แล้ว

      same here :D

    • @Antoniooo1206
      @Antoniooo1206 4 ปีที่แล้ว

      @@karinsedlakova6316 Same here. Started to love it because of him. It's fascinating how our body deals with everything, really asthonishing.

    • @solomonyokim6762
      @solomonyokim6762 2 ปีที่แล้ว

      Same too.

  • @okodioscar7518
    @okodioscar7518 ปีที่แล้ว +2

    This man is very good in teaching because he made work simple by adding jokes that makes fun in lectures. Is so amazing and I look for his channel first before others

  • @sarapamintuan1879
    @sarapamintuan1879 2 ปีที่แล้ว +13

    i have been seeing many of your videos and i just want to say thank you! you´re so so so good at explaining!!!

  • @sandraschmelzer9961
    @sandraschmelzer9961 ปีที่แล้ว +1

    I am eternally grateful for your videos. I've watched a few of them several times and I have your diagrams in my head which help me remember what is going on during all these metabolism pathways and cycles :-)

  • @osielcecenas7669
    @osielcecenas7669 4 ปีที่แล้ว +11

    restudying gluconeogenesis for my MCAT & I can say this is probably the best source I have had for information. Better than khan academy and Kaplan MCAT test prep

  • @nourhaedar1618
    @nourhaedar1618 2 ปีที่แล้ว +1

    You've saved my education! Thank you from the bottom of my heart.
    -from a pharmacy student in Syria.

  • @NastroArzurro
    @NastroArzurro 4 ปีที่แล้ว +5

    You simply make the best biochemistry-videos!!! Thanks so much man!

  • @montaserhattab6152
    @montaserhattab6152 5 ปีที่แล้ว +56

    19:50 absolutely nooothing lamo

  • @paulinaleon6029
    @paulinaleon6029 4 ปีที่แล้ว +3

    What a beautiful way to explain biochemistry, I entIrely love your channel!

  • @Luna-xl7dv
    @Luna-xl7dv 11 หลายเดือนก่อน +1

    It was absolutely fun and enjoyable, thanks for being there, you're a miracle that happened in my life ❤❤

  • @hanamostafa5268
    @hanamostafa5268 2 ปีที่แล้ว +3

    Thanks so much!! You man is a true legend, and your videos is so valuable, you make a very complicated and long topic that I hated in Uni into a story with smiley enzymes and simple metabolism :) Thanks for being there and always trying to make your best and for the tonnes of efforts that is placed in these videos, Looking forward for more videos Ninja Nerd!!

  • @32-gokilavanis95
    @32-gokilavanis95 4 ปีที่แล้ว +5

    Really amazing lecture.... Now I am interested to study biochemistry.. Thanks a lot for giving me hope ❤❤❤

  • @rajhellskitchen3658
    @rajhellskitchen3658 2 ปีที่แล้ว

    We are grateful for ppl like you. Thank you bro

  • @888167
    @888167 4 ปีที่แล้ว +36

    At 7.48 you probably meant "in the muscle" not "in the liver". Otherwise it would be Glucokinase not Hexokinase
    Great video as always mate you guys are a blessing

    • @erwinbla1401
      @erwinbla1401 4 ปีที่แล้ว +5

      Gucokinase is just one specific isoform of Hexokinases -> Glucokinase = Hexokinase4

    • @seren1104
      @seren1104 3 ปีที่แล้ว +1

      yeah, it should be glucokinase cause we're in muscle

  • @alih6953
    @alih6953 3 ปีที่แล้ว +1

    Your videos are amazing. They deserve a million. Some silly youtubers buy a t-shirt and get 1 million that I don't agree with You deserve everything

  • @janbazkhan4222
    @janbazkhan4222 6 ปีที่แล้ว +1

    hii sir ur lectures are really fruitfull the way u explain the things is very esay to understand ..i mostly follow ur lectures for my MACs exam preparations.bravo and praiseworthy...

  • @dr.varsharajan3153
    @dr.varsharajan3153 2 ปีที่แล้ว

    Seriously dude ...such a wonderful explanation .. thankyou for making me understand this concept

  • @laluna5548
    @laluna5548 5 ปีที่แล้ว +1

    If you ever go out of your mind and decide to visit a shitty town of Belgrade, Serbia-you have a place to stay free of charge. I am not even kidding. You are my hero! Thank you so much. I am bad at memorizing, but understand logic-and that is what you use. Simply amazing :)

  • @mehrzikamel7123
    @mehrzikamel7123 3 ปีที่แล้ว +2

    You are amazing man my appreciation to you, biochimistry is so cool with your explanation and encourage student to love the whole medicine big thks dude)

  • @umerbinshabir6561
    @umerbinshabir6561 5 ปีที่แล้ว +2

    How beautiful it was.....thank you sir❤️

  • @rizwanilyas4289
    @rizwanilyas4289 2 ปีที่แล้ว

    No one can compete such a great legend 🙂

  • @dondamishitha468
    @dondamishitha468 3 ปีที่แล้ว

    Your like osm sir
    Really your videos boosting me confidence in biochemistry
    Our teachers just read ppt, rather they explain nothing, u r saving me in building up my subject in biochemistry
    Thank u very much😊

  • @user-hw9bh9ro3t
    @user-hw9bh9ro3t 5 ปีที่แล้ว +9

    teacher who I never have like him , thanks from all my heart

  • @saraa.h3787
    @saraa.h3787 3 ปีที่แล้ว +1

    this channel deserves 1 million subscribers and moooreee

  • @Sadaf0711
    @Sadaf0711 2 ปีที่แล้ว

    Thanks a lot for clearing the whole concept

  • @mujtabaalizafar5680
    @mujtabaalizafar5680 4 ปีที่แล้ว +1

    the last two minutes of this video >>>> literally everything

  • @ughsirius
    @ughsirius 3 ปีที่แล้ว

    THANK YOU SOOOO MUCH!! YOU'RE A LIFE SAVER ❤

  • @whatev3857
    @whatev3857 3 ปีที่แล้ว

    Zach, thank you so much, I finally understood it thanks to you💓💓💓

  • @gattac900
    @gattac900 5 ปีที่แล้ว +2

    Best bio-chem vids in the TH-cam.

  • @sarrahkhanrahim2917
    @sarrahkhanrahim2917 5 หลายเดือนก่อน

    You are seriously a life saver!Ive read few comments and totally can relate with them you truly are very good at your work.I see you erasing your mistakes with your fingers pls use a finger cap or something as those ink molecules can be harmful or even carcinogenic.Your safety is very important to your students and your family!
    one of your students from India❤️

  • @AIZIKOVICHLARA
    @AIZIKOVICHLARA 4 ปีที่แล้ว +3

    Great explanations! Thanks a lot ! (:

  • @marbeliscopello7153
    @marbeliscopello7153 ปีที่แล้ว

    Muchas gracias, muy bonito la interrelación entre el músculo, hígado y sangre en la gluconeogenesis.

  • @sandemichael7242
    @sandemichael7242 ปีที่แล้ว +1

    I love your lecturers sir just keep it up 🙏🙏

  • @SalmaAhmed-kt2nu
    @SalmaAhmed-kt2nu 5 ปีที่แล้ว

    thank you for everything that you do

  • @manulanimsara
    @manulanimsara 2 ปีที่แล้ว

    You are the best thing that i found on youtube brother❤️😍

  • @MuhammadTanveer-vt4xu
    @MuhammadTanveer-vt4xu 4 วันที่ผ่านมา

    Amazing explanation.Thanks Sir

  • @factsinshortslm
    @factsinshortslm ปีที่แล้ว

    From now on, I should pay the tuition for you. Btw, you're videos are not boring at all, I enjoy watching them . Biochemistry is fun with YOU and ONLY YOU.

  • @potatowithlimbs1335
    @potatowithlimbs1335 3 ปีที่แล้ว

    u the best dude .... seriously u saved my life !!

  • @jacquelinelabovitz4613
    @jacquelinelabovitz4613 6 ปีที่แล้ว +1

    best teacher out there!

  • @motivationpilldaily
    @motivationpilldaily 2 ปีที่แล้ว

    Thank you so much! This was amazing.

  • @technooooooooooful
    @technooooooooooful 6 ปีที่แล้ว

    you are simply great, students from Serbia support you!!

  • @pierpaolotofani3929
    @pierpaolotofani3929 5 ปีที่แล้ว +2

    Great video. You are very talented !

  • @saimsiddiqui9893
    @saimsiddiqui9893 ปีที่แล้ว

    Man you make it so easy, thanks alot

  • @IRENESAKAYA
    @IRENESAKAYA ปีที่แล้ว

    It's awesome , u deserve the very best Mr😇💯

  • @sachinilakshika2213
    @sachinilakshika2213 5 ปีที่แล้ว +1

    perfect explanation!

  • @andreiasousa9688
    @andreiasousa9688 6 ปีที่แล้ว +30

    Thanks again for all the videos! Just a random question/suggestion: would it be possible for you to put a final picture of the board in the end? Sometimes it would be really helpful to check a little detail instead of watching the whole video again! But anyways, I'd really like to thank you for all the content. Y'all are just amazing

    • @NinjaNerdOfficial
      @NinjaNerdOfficial  6 ปีที่แล้ว +36

      This is something we have recently started to do in all of our videos. Thanks for the suggestion!

    • @andreiasousa9688
      @andreiasousa9688 6 ปีที่แล้ว +3

      Ninja Nerd Science wow thanks! That's just great. Can you please check my previous comment on the gluconeogenesis video? :)

    • @farisabbas7897
      @farisabbas7897 6 ปีที่แล้ว +1

      Andreia Filipa Lopes Sousa +1

  • @J3ug
    @J3ug ปีที่แล้ว +1

    Also Glucagon phosphorylates Pyruvate Kinase and therefore inhibits conversion of PEP back into Pyruvate.
    This has the effect of diverting PEP to the synthesis of glucose!

  • @AishaGama-sl7ll
    @AishaGama-sl7ll 5 หลายเดือนก่อน

    This is an amazing explanation

  • @zns2871
    @zns2871 3 หลายเดือนก่อน

    Thank you for this great inspiration

  • @Aresearcher
    @Aresearcher 3 ปีที่แล้ว

    Thank you for amazing lectures

  • @alirezaahmadi1777
    @alirezaahmadi1777 2 ปีที่แล้ว

    Perfect teaching process ❤❤😍

  • @macebunny5516
    @macebunny5516 5 ปีที่แล้ว +1

    Amazing ... thank you!!!

  • @linadader6948
    @linadader6948 3 หลายเดือนก่อน

    amazing man! god bless you! thank you so much !

  • @zaharramaearucan6479
    @zaharramaearucan6479 2 ปีที่แล้ว

    Thank you so much! Im a huge fan here from the Philippines. I am currently taking my 3rd year in college.

  • @ughsirius
    @ughsirius 3 ปีที่แล้ว +3

    I have a question: why does a higher ADP/ATP ratio (as in a low energy state within the cell) inhibit Pyruvate Carboxylase and Fructose 1,6 Bisphosphatase? Don't we need more energy in a low energy state? And so shouldn't gluconeogenesis increase when the cell has low energy, so more glucose is made and can be broken down for energy?

  • @drlight7547
    @drlight7547 3 ปีที่แล้ว

    very helpful 😍 THANK YOU!

  • @sabelomanqobatembe9760
    @sabelomanqobatembe9760 5 ปีที่แล้ว

    videos are cool make it easy for many people to understand and i would to see more videos such as malonyl coA pathway ,fatty acid biosynthesis and many more other than that you the best.

  • @mazinesam7183
    @mazinesam7183 6 ปีที่แล้ว +11

    thank you for making this difficult topics easier to us
    You are even better than khan academy 💀for real.thank you❤

    • @IWAC2013
      @IWAC2013 4 ปีที่แล้ว

      way better, its not even close tbh

  • @AshwaniKumar-gk9ng
    @AshwaniKumar-gk9ng 4 ปีที่แล้ว +2

    Love from India
    Thank you so much sir

  • @shreeshchakraborty3121
    @shreeshchakraborty3121 3 ปีที่แล้ว +1

    Sir, You are amazing ❤️

  • @MegaCheerleader1999
    @MegaCheerleader1999 ปีที่แล้ว

    Thank you so much!!! So useful!

  • @shambhavigupta4263
    @shambhavigupta4263 3 ปีที่แล้ว +2

    shoutout to this man for making me pass biochem

  • @iloveu136
    @iloveu136 2 ปีที่แล้ว

    thank you for everything💞

  • @eduardob.r.2087
    @eduardob.r.2087 6 ปีที่แล้ว

    Muito obrigado!!!!! You're amazing, dude!!

  • @minatonamikaze3193
    @minatonamikaze3193 4 ปีที่แล้ว +1

    Great video, Thank you

  • @andahuzaifa5081
    @andahuzaifa5081 5 ปีที่แล้ว

    Brother.... very helpful video...👍👍👏👏

  • @caligtannomerleed.9535
    @caligtannomerleed.9535 3 ปีที่แล้ว +1

    Sir thank you for this well informing video, might as well ask if there is a difference of rate limiting vs regulatory. Is pyruvate Carboxylase the rate limiting or is it fructose 1-6 biposphatase ?

  • @user-qq7ww4ub6k
    @user-qq7ww4ub6k 2 หลายเดือนก่อน

    Thankuu so much...your teaching method outstanding

  • @minaltariq1191
    @minaltariq1191 4 ปีที่แล้ว +6

    Thank u so much .... 👌✨
    It's awesome ....
    MashAllah ....
    May ALLAH ♥️ bless u with endless blessings ✨😊

  • @popitandrelax
    @popitandrelax 4 ปีที่แล้ว

    explained
    AMAZİNG!!!
    !!رائع الشرح
    Açıklama şahane!!!

  • @anuachu2146
    @anuachu2146 5 ปีที่แล้ว +1

    Awsome sir,we love you more.....

  • @evangelinedas8670
    @evangelinedas8670 3 ปีที่แล้ว

    Hey your videos are of great help to understand biochem more easily.Can you please clarify my doubt?
    what is the role of glycogen in the muscle when the muscle is injured?????
    Thank you so much!

  • @abbasnasir8832
    @abbasnasir8832 3 ปีที่แล้ว +3

    Biochem exam is in 15 hrs and he's gonna save me❣️

  • @virtuesbernadettecadile6869
    @virtuesbernadettecadile6869 3 ปีที่แล้ว +1

    Thank you so much!!

  • @lalith23
    @lalith23 3 ปีที่แล้ว +1

    Thank you so much ❤❤

  • @romagebreyesus1590
    @romagebreyesus1590 4 ปีที่แล้ว

    l enjoyed all your explanations.

  • @sahibwahab4867
    @sahibwahab4867 10 หลายเดือนก่อน

    Thanks sir today I clear my biochemistry only because of you

  • @drghada-pe4um
    @drghada-pe4um 6 ปีที่แล้ว +1

    So helpful
    Thank you ❤️

  • @janhvi521
    @janhvi521 2 ปีที่แล้ว

    Nice work!!

  • @user-sq3ls6sj7i
    @user-sq3ls6sj7i ปีที่แล้ว

    dude. THANK YOU

  • @jdegiov
    @jdegiov ปีที่แล้ว

    Another source of lactate comes from red blood cells which can only carry out anaerobic respiration. Keep up the good work.

  • @desmondlarteylaryea4637
    @desmondlarteylaryea4637 2 ปีที่แล้ว

    It was really helpful
    Thanks 🥺🥺🥺

  • @olimpiagherghisan8746
    @olimpiagherghisan8746 3 วันที่ผ่านมา

    God bless this man

  • @HolisticNootropics
    @HolisticNootropics 2 ปีที่แล้ว

    Awesome vid! Question: Why does Alanine cycle happen vs the Cori Cycle?

  • @muhammadhuzefa3568
    @muhammadhuzefa3568 3 ปีที่แล้ว +1

    You are KING ❤️

  • @abdalrahmanalhendi6188
    @abdalrahmanalhendi6188 4 ปีที่แล้ว +1

    Thank you so much

  • @nalnalhee_seoul
    @nalnalhee_seoul 3 ปีที่แล้ว +6

    I like your singing “absolutely nothing~~” :-D

  • @alialiraqi2762
    @alialiraqi2762 2 ปีที่แล้ว

    Amazing
    Thanks

  • @udarachandrathilaka5200
    @udarachandrathilaka5200 ปีที่แล้ว

    Thank you very much.😍🤗

  • @Kesenschaf
    @Kesenschaf ปีที่แล้ว

    Thank you !!!