thank you for breaking this down simplistically, your energy is sooo contagious. It is wonderful to watch a lecture (even if short) with someone who is passionate about teaching and about biology/anatomy/physiology.
So glad at 6:48 you mentioned that FA can not turn into glucose. One of my bugbears that many get this wrong. Krebs & radiocarbon labelled C14 sorted that out years ago. Loving your channel. This was me in the early 90s. Shame the interweb wasn't around then! 😀
I don't normally comment on TH-cam but I should give credit where credit is due. You explained very complex processes into an easy to understand 9 minute video, awesome!
I’m in the midst of my physiology class and wanted to see how gluconeogenesis worked and then you explained something about my type 1 diabetes I never understood! You’re amazing man to say the least keep it up
I can't see the Glut4 reseptor that closes the door for carbs and fat when the osmotic bloodglucose pressure gets high. This is reversed when the blood glucose goes down. After water fasting for 3 days, you alleviate this mechanism, and the Glut 4 is pushed out from the membran and are open until the blood pressure gets high again. This feature is to protect the cells. Remember when the Randal cycle is activated the Glut 4 reject both karbohydrats and fat. So, you're not oxidizing fat while this is activated. Nice video, like the energy.
Your way of explanation is very simple and concentrated on basics. I am from engineering background but preparing for indian forest service with zoology optional...your videos are helping me alot...
Its wrong to consider fuel sources as "preferred". Evolution has directed the sequence of fuel source selection based on damage control. Glucose is used early because if not used for energy it will non-enzymatically glycate cells - damaging and killing them. Cells constrict the GLUT4 receptor when replete with fuel based on current energy demand levels. If there is an excess of damaging glucose, evolutions design selection is for that glucose to be left in the serum as glycation damage to blood cells is mitigated by their rapid turnover. If high levels are maintained, glucose damage expands in magnitude and location. Benign fuel sources are utilized after glucose BECAUSE they are benign. Gluconeogenesis creates all the energy needed precisely when it is needed so there is no excess to cause damage via glycation. If you didn't eat a single carb and only ate fat and protein you would have all the energy required as and when needed without glycation.
What a nice way of explaining things! Well, I like it mostly because it is over simplified (no Organic Chemistry anywhere) BUT that is precisely great about these videos. Not everyone (or rather almost no one) needs to memorise all those chemical reactions! What most of us need to know is how what we eat affects us and when or why (triggers) - the logical connections and not the chemical reactions!! Wonderful presentation too. Thanks a lot.
Thanks for your efforts Doctor. I would like, with your permission, to point you to a point, which is to download the image of the blackboard in the description below. Thank you very much, and my sincere respect to you👍👍👍👍👍👍👍
Can you do another video where you explain what happens when insulin levels are high and glucose is low? I have an insulinoma. A tumor that makes insulin. Enough insulin for 20 people. So my deal is that my insulin is high and glucose goes low. I want to know how the presence of high insulin changes things. I know it stops ketones production as well as gluconeogenesis of glycogen stores. So that all that is left is muscle tissue to be used to make glucose.
Ketones are NOT turned into glucose in the brain (min 8:20). Ketones be oxidized in brain to provide ATP energy and lessen glucose consumption under fasting (actually starvation) conditions. Fatty acids (and ketones) can NOT be converted to glucose. The substrates for gluconeogenesis are lactate, glycerol and amino acids.
I came across your video, just wondering how lactate buildup can help diabetic, who has high glucose and high triglycerides. Should he run more or should not run at all.
High Cortisol or cushons and would Nucleic acid or metformin help ( Gluconeogenesis is also high cortisol ?) Absorbsion of Vit D vs ammino acds or Deanimation ?
Hi Dr Mike. Hope you can clarify as I'm a bit confused: You say that insulin, glucagon, cortisol and noradrenaline (norepinephrine) are involved in gluconeogenesis, but I thought it was adrenaline/epinephrine and not norepi! Which is correct, noradrenaline or adrenaline? Thank you
It can be both. Hyperglycemia and hypoglycemia. Diabetes is in effect a disregulation of metabolism, glucose metabolism in particular. Glucose can have a deletrious effect on cells if not controlled.
اللهم صل على محمد وعلى آل محمد كما صليت على إبراهيم وعلى آل إبراهيم إنك حميد مجيد، اللهم بارك على محمد وعلى آل محمد كما باركت على إبراهيم وعلى آل إبراهيم إنك حميد مجيد ١٠ (قل هو الله أحد• الله الصمد• لم يلد ولم يولد• ولم يكن له كفوا أحد) ١٠ أستغفر الله العظيم الذي لا إله إلا هو الحي القيوم وأتوب إليه ١٠٠ لا إله إلا الله وحده لا شريك له له الملك وله الحمد وهو على كل شيء قدير ١٠٠ سبحان الله والحمد لله ولا إله إلا الله والله أكبر وتبارك الله سبحان الله والحمد لله ولا إله إلا الله والله أكبر لا إله إلا الله وحده لا شريك له له الملك وله الحمد وهو على كل شيء قدير ١٠٠ سبحان الله وبحمده ١٠٠ لا حول ولا قوة إلا بالله سبحان الله الحمد لله لا إله إلا الله الله أكبر أستغفر الله لا إله إلا أنت سبحانك إني كنت من الظالمين سبحان الله العظيم وبحمده يا ذا الجلال والإكرام حسبي الله ونعم الوكيل ***********
Dr MIke is my favourite teacher, who agrees?
He is the best, compared to the other videos out there.
The best thing about your explanation is how you correlate several different clinical aspects with the basics, making it even easier to understand.
Studying for my MCAT wondering where your channel was throughout my entire undergrad. Thank you for the simplest explanations Dr. Mike!!
Very comprehensive in just 10 minutes. Thank you Dr. Mike
thank you for breaking this down simplistically, your energy is sooo contagious. It is wonderful to watch a lecture (even if short) with someone who is passionate about teaching and about biology/anatomy/physiology.
So glad at 6:48 you mentioned that FA can not turn into glucose. One of my bugbears that many get this wrong. Krebs & radiocarbon labelled C14 sorted that out years ago. Loving your channel. This was me in the early 90s. Shame the interweb wasn't around then! 😀
Sir you are simply brilliant you can explain better than a computer
I don't normally comment on TH-cam but I should give credit where credit is due. You explained very complex processes into an easy to understand 9 minute video, awesome!
I wish you were my lecturer! You make it so easy to understand!!
Informative and so much easier to comprehend the bigger picture compared to other videos. Please keep posting videos!
am i dumb or did he skip how it goes from pyruvate to phosphenolpyruvate?? (one of the irreversible rxns of glycolsis)
You're a life savior. Don't know how you managed to answer all my questions in one video, connecting it to diabetes etc. - from an M1
Really loved this summary! All the high yield stuff :) Thanks a million!
I’m in the midst of my physiology class and wanted to see how gluconeogenesis worked and then you explained something about my type 1 diabetes I never understood! You’re amazing man to say the least keep it up
This has been really gone a long way in understanding the topic❤❤❤.
Thanks so much.
Definitely an amazing amazing teacher!!!!!
I can't see the Glut4 reseptor that closes the door for carbs and fat when the osmotic bloodglucose pressure gets high. This is reversed when the blood glucose goes down. After water fasting for 3 days, you alleviate this mechanism, and the Glut 4 is pushed out from the membran and are open until the blood pressure gets high again. This feature is to protect the cells. Remember when the Randal cycle is activated the Glut 4 reject both karbohydrats and fat. So, you're not oxidizing fat while this is activated. Nice video, like the energy.
Your way of explanation is very simple and concentrated on basics. I am from engineering background but preparing for indian forest service with zoology optional...your videos are helping me alot...
My thesis is about diabetes and I'm also studying biochem. This is just a great video thank you so much
Wow you made it so simple and easy. You're the best. 👌
watched many other videos, this one is the easiest to understand. thanks
Maaan you are great❤❤❤❤ I’m a medical student and you helped a lot with my final exam
Its wrong to consider fuel sources as "preferred". Evolution has directed the sequence of fuel source selection based on damage control. Glucose is used early because if not used for energy it will non-enzymatically glycate cells - damaging and killing them. Cells constrict the GLUT4 receptor when replete with fuel based on current energy demand levels. If there is an excess of damaging glucose, evolutions design selection is for that glucose to be left in the serum as glycation damage to blood cells is mitigated by their rapid turnover. If high levels are maintained, glucose damage expands in magnitude and location.
Benign fuel sources are utilized after glucose BECAUSE they are benign.
Gluconeogenesis creates all the energy needed precisely when it is needed so there is no excess to cause damage via glycation.
If you didn't eat a single carb and only ate fat and protein you would have all the energy required as and when needed without glycation.
😮.. makes good sense!
Thank you Dr Mike. Your videos are amazing!
You have gained your self a subscription from a BPharm student of Zambia.
Your lectures are damn easy to understand concept...they're just mind blowing
Great and simple explanation thanks!
Simple and easy. Thank you so much you saved me so much time ❤
I always understand i listen and watch the videos, i will a lesson bioenergetics and TS cycle please DR Mike
Amazing! Thank you!
He’s gorgeous however these Dr Matt Mike videos are great to watch
I agree it's brilliant. thank you.
What a nice way of explaining things! Well, I like it mostly because it is over simplified (no Organic Chemistry anywhere) BUT that is precisely great about these videos. Not everyone (or rather almost no one) needs to memorise all those chemical reactions! What most of us need to know is how what we eat affects us and when or why (triggers) - the logical connections and not the chemical reactions!! Wonderful presentation too. Thanks a lot.
Thumbs up for the amazing information keep it going you are doing a great job 👍👍👍
How I love this channel...Thanks a lot
Thanks for the video Dr Mike but my eyes just can't move away from those biceps! xx
GREAT TEACHER THANK YOU!
You are amazing !!!!
I have a question. During Intermittent Fasting can brain get glucose and survive by gluconeogenesis process?
So clear thanks
THANK U SO MUCHH
very good. I research in metabolism, and these lectures help me recap some key points!
Thanks for your efforts Doctor. I would like, with your permission, to point you to a point, which is to download the image of the blackboard in the description below. Thank you very much, and my sincere respect to you👍👍👍👍👍👍👍
Its not the absence of insulin that triggers the breakdown of triglycerides, its glucagon
❤❤❤ Lovely.
Excellent! Thank you
Thank you
A plus lecture!
PERFECT!
Wonderful video worth watching God bless you
Can you do another video where you explain what happens when insulin levels are high and glucose is low? I have an insulinoma. A tumor that makes insulin. Enough insulin for 20 people. So my deal is that my insulin is high and glucose goes low. I want to know how the presence of high insulin changes things. I know it stops ketones production as well as gluconeogenesis of glycogen stores. So that all that is left is muscle tissue to be used to make glucose.
Very educational. Thank you
Wow. Excellent.
Wow. I appreciate it.
I got it !! :)
Thank you. You have a gift.
Thanks man
How are the kidneys involved in gluconeogensis? Is it the noradrenaline and cortisol from the adrenal cortex?
Awesome! Thank you😊
handsome and smart man.. such a good combination..
Thanks for video, really helped!
Ketones are NOT turned into glucose in the brain (min 8:20). Ketones be oxidized in brain to provide ATP energy and lessen glucose consumption under fasting (actually starvation) conditions. Fatty acids (and ketones) can NOT be converted to glucose. The substrates for gluconeogenesis are lactate, glycerol and amino acids.
I can't thank you enough :')
Dude has knowledge. Dude is Jacked. Dude has incredible speaking skills. I wanna be Dude.
Wow, thanks
love you
great teaching.
You’re good omo 🚀🚀
Thank you so much!! Very helpful:")
I came across your video, just wondering how lactate buildup can help diabetic, who has high glucose and high triglycerides. Should he run more or should not run at all.
THANKS FROM
TEL AVIV
DR BERAR
High Cortisol or cushons and would Nucleic acid or metformin help ( Gluconeogenesis is also high cortisol ?) Absorbsion of Vit D vs ammino acds or Deanimation ?
Im a type 2 diabetic. Will a huge protein meal spike my glucose level? Im on a low carb diet.
So next time i need to squat rapidly till i feel the burn and my brain will be fed
F-ing awesome video!
يخربيت. الجمدان 😂😂😂😂😂❤
Hi Dr Mike. Hope you can clarify as I'm a bit confused: You say that insulin, glucagon, cortisol and noradrenaline (norepinephrine) are involved in gluconeogenesis, but I thought it was adrenaline/epinephrine and not norepi! Which is correct, noradrenaline or adrenaline? Thank you
I was looking at this guy, and I suddenly had a profound urge to get a prostate exam.
sick
Time for a quick adhd hyper focus
thnks
Can you do something about Amino acid metabolism..like how it becomes Urea,stuff like that?
U saved me🙏🙏🙏🙏
damn saan you hella slick!
Sir... Video about portal system... Please.
Remember the days when we used to get our information from the bros at the gym.
Dr Mike is fine
7:22 you said there is low glucose in diabetes. Aren't glucose levels high in Diabetes?
It can be both. Hyperglycemia and hypoglycemia. Diabetes is in effect a disregulation of metabolism, glucose metabolism in particular. Glucose can have a deletrious effect on cells if not controlled.
They are high. Especially with type 1. It confused me as well.
so many paid commenters in this video, same names as the paid commenters in other videos
I’m a plant
m8 slow down a bit wud ya, amazing concepts though;))
Ummm..now can you have this exact same video in english??
What?
اللهم صل على محمد وعلى آل محمد كما صليت على إبراهيم وعلى آل إبراهيم إنك حميد مجيد، اللهم بارك على محمد وعلى آل محمد كما باركت على إبراهيم وعلى آل إبراهيم إنك حميد مجيد ١٠
(قل هو الله أحد• الله الصمد• لم يلد ولم يولد• ولم يكن له كفوا أحد) ١٠
أستغفر الله العظيم الذي لا إله إلا هو الحي القيوم وأتوب إليه ١٠٠
لا إله إلا الله وحده لا شريك له له الملك وله الحمد وهو على كل شيء قدير ١٠٠
سبحان الله والحمد لله ولا إله إلا الله والله أكبر وتبارك الله
سبحان الله والحمد لله ولا إله إلا الله والله أكبر
لا إله إلا الله وحده لا شريك له له الملك وله الحمد وهو على كل شيء قدير ١٠٠
سبحان الله وبحمده ١٠٠
لا حول ولا قوة إلا بالله
سبحان الله
الحمد لله
لا إله إلا الله
الله أكبر
أستغفر الله
لا إله إلا أنت سبحانك إني كنت من الظالمين
سبحان الله العظيم وبحمده
يا ذا الجلال والإكرام
حسبي الله ونعم الوكيل
***********
So, ya wanted to go keto, did ya?? 😉
How is this helping me ? I’m more confused 🥹