Pyruvate Pathways & Metabolism

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My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.

[@jobettoli]

"rewatch it if you need to" hits different the 5th time around

[@ayham2000ify]

LOOL

[@fitness-rebels6136]

Pult g guiden

[@manjushreeinamdar1242]

I swear right!!

[@Radhikamorey111]

Died laughing

[@beebob7136]

Haha already on my 3rd time lol

[@ThienTruong-iy5ix]

i just don't know how there's people out there that are able to break down complex mechanism into easy and digestible content like this. These people are the real smartz people in my eyes.

[@josphellihsilak4588]

This video satisfies what I see as teaching biochems biggest misstep -- missing the forest for the trees. I get so many students that are so dialed in to specifics and miss how much easier it is to see it as a peice of a bigger picture. Nice job.

[@GodBecameMan]

I have abandoned all to concentrate on your videos! Thank you. May the Lord Jesus, the Christ bless you.

[@mmmmkkkk4331]

There is no God accept Allah

[@mmmmkkkk4331]

لا إله إلا الله وحده لا شريك له له الملك وله الحمد وهو على كل شيءٍ قدير

[@GeminiSmilesz]

for someone that struggles with this topic for years, I got it today!!! thank you

[@drswetaruparel]

All the biochemistry videos are very very very helpful !!! 👍

[@niceangel9779]

A million thx for ur videos ...I m not learning for USMLE but ur videos help me a lot to get the most important info I gotta have 💛😊

[@damonrossouw9732]

You forgot ethanol fermentation
Nice video though ❤ very clear and informative

[@flipgamer07]

would it be possible to get the glycolysis video back up?

[@marydavid9473]

yes that would be great I've been looking for it!

[@monika246]

And gluconeogenesis too

[@vincefox8]

He just posted glycolysis again yesterday!

[@nganguyenthanh4952]

​@@marydavid9473😅

[@HHM167]

Cofactor for PDH are Tender ( thymine = B1), loving ( lipoic acid) care ( CoA = B5) for ( FAD = B2) naD ( NAD = B3 )

[@abrahamkayal9665]

amazing video man, you did a really good job of explaining that so it sticks in your head, thanks !

[@cassinicristine5017]

Thank you so much for your channel and the biochem videos 🙏

[@filmonhaile3327]

The cahill cycle also gets rid of ammonium ions from muscle cells that has accumulated from muscle metabolism. In the liver the amin groups enter the urea cycle.

[@fook12345]

thanks.

[@esvittie8515]

Precisely

[@agh6452]

Thank you sooo very much for the greatest video 💐💐💐💐

[@arsaghazal5348]

Can you please put the gluconeogenesis video up? You're amazing! Always struggled with Biochem :( Thank you!!

[@ChrisDebbie-tq2po]

God bless you richly

[@manudattaraavi4700]

Too good lecture sir I am so grateful to god to provide u as lecturer

[@ravenmcmillin9533]

DIRTY - can we plllsss get glycolysis & gluconeogenesis back D:
- a beloved patron

[@jvpadilla9905]

it is mesmerizing how our body works and trick itself.

[@Merllabelle]

Thank you so much 😊 DirtyMed!!! Everyone needs to see this

[@Akordio94]

Wow, you are good! So concise

[@matthewfish2786]

Brilliantly explained.

[@edcrfvtgbyhnujmikolpqazwsx]

Best explanation I've seen on the pyruvate pathways. Thank you!

[@ashypharaoh8407]

are you a doctor now

[@rahmakamil1993]

Perfect 👌 Thank you so much

[@safaemrecakr2040]

You're great. 🤗

[@MitineTienare-tj9fh]

Thankyou so much. This video helps me .great job

[@ast1848]

Thank you!

[@rucs6403]

Thanks a lot. You cleared my concepts

[@nimraaslam7715]

You are the best!

[@drmartijnbijker]

Great overview. What about Acetyl-CoA and lipid synthesis besides just TCA cycle entry?

[@NadiaFleurantin]

Excellent.

[@simodu6878]

Dr. Ryan also once mentioned that 'Focus on the big pic first and then the details" -- Great minds think alike

[@HarrydeBont]

I'm studying metabolism (being an Eletrical Engineer) and found myself in a rabbit hole, now I see a light at the end of the tunnel. Thanks!

[@frameshift_mutation]

Why do electrical engineers study metabolism?

[@HarrydeBont]

@@frameshift_mutation Curiosity!

[@raknieborak8937]

these videos are the best

[@shinn-tyanwu4155]

Great 😊😊

[@teambunny8382]

Lots of Thanks 😍

[@abdullahorakzai995]

Best explanation

[@spideraha4276]

Lots of thanks

[@tanzinasha4665]

Thank you

[@LorindaJeanMD]

Great! Thank you!

[@mitaladenisa-andra4456]

Thank you soooo much 🙏😊. Great job :)

[@imranulhoda1005]

Thank You ❤️

[@alexandrahovsepian7415]

Such a useful summary! Thank you !

[@itsnimrakhan22]

Thank you very much.👏💕

[@maitribhavsar1300]

NICELY EXPLAINED.

[@prernasoni5386]

Succha biochem gem you are!!❤️

[@DrCA1neuron]

Thank you so much😊.

[@Ray-qr7wt]

Perfect!!

[@theitdocchannel540]

Thank you so much

[@TCBytom]

This guy has a pedagogical talent.

[@crimzonart1269]

Brilliant

[@dr.tranngocthien]

Thank you very much!

[@drcaocuong]

thanks you!

[@dancemusic1919]

Can you please post gluconeogenesis. Your videos are amazing.

[@UnknownUser-hj4ng]

Thankyou

[@ivanpalomera]

Better than the USMLE RX videos. Amazing job thank you!

[@carisamclean6716]

I agree 100%. I do not understand Rx biochemistry videos, they skip over high yield stuff

[@nganguyenthanh4952]

​@@carisamclean6716😂

[@SuperLika17]

great

[@asannajat6173]

I hope you make a lot of videos on biochemistry.😪😪

[@amnasahar2746]

THANK YOU FOR THIS 😭

[@drnaazneenmohammed1094]

Please make a video on various types of aphasia and their site of lesion

[@marky5493]

As a layman welder, this is so fascinating, it's way over my head and I suspect my gp as well.
Who does a person go to that would be able to do tests like these and see any problems associated with them??
Many Thanks!

[@l.gregory3866]

studying for my nutrition board exams....thanks!!

[@mizzteeq6885]

Do you make pharmacology videos? I need one on diabetes drugs please...

[@lalouna2012]

THANK YOUUUUUUU

[@suditisharma5574]

LOVE YOU

[@shanewaldrop3513]

Minor clarification pyruvate goes into mitochondria before converting to OAA or acetyl-CoA

[@habib080]

any chance the glycolysis video will be posted? love your content and thanks for the step1 schedule! Best $1 i spent haha

[@vincefox8]

He just posted glycolysis yesterday!

[@daniels7460]

well explained, but the way to EtOH is missing. (pyruvate decarboxylase)

[@yvonnenamwila6731]

What is the name of the reaction that pyruvate undergoes under aerobic conditions?

[@sneharao7074]

This is god’s work

[@damienroland5350]

I can't find the glycolysis video

[@alifarooqui726]

I've seen a few questions regarding LDH deficiency: NAD+ accumulation is seen and leads to inhibition of glycolysis leading to exercise intolerance.

[@raahimbashir3482]

Wrong
Pyruvate accumulates
NAD+ is depleted
Increased NADH/NAD+ inhibits glycolysis and TCA cycle , and favors lactate production

[@valarmorghulis364]

Does Cahill cycle transport Nh3 or Carbons??

[@youssefelkamilii1764]

i love you maaan you are the best

[@michaelsrowland]

If someone doesn't eat carbs can they still generate pyruvate

[@kavyag4024]

Please upload gluconeogenesis too

[@maxbilo6191]

7:11 CAHILL CYCLE
8:50 Cahill cycle full schema

[@1412Z]

Thank you so much! God bless you.

[@jerahlyncorona7]

just wondering why RBC is included in anaerobic glycolysis when technically they are Oxygen carrier :(

[@sherzadhaji6303]

Mistake that should be corrected
The muscles have stored g6p but cannot be converted to glucose that is because muscles lack g6 phosphatase.. So it is g6p that is converted to alanine not glucose. Because if that was the case why would muscles convert its glucose to glucose again. Correct this mistake plz.

[@grejuli97]

where is the fermentation to acetaldehyde and then to ethanol in this?

[@anatomy2201]

Op bro

[@andyrendon7753]

I would love to buy you a pint saving my grade in biochemistry

[@brandoncalvert7097]

Thanks dirty

[@moon-zf1em]

Can you put arabic translation please. Watching you from Iraq

[@saloya2712]

where is the gluconeogenesis video?

[@cassinicristine5017]

Can you, please, explain why in Pyruvate DH deficiency or in B1 def.in alcoholics, pyruvate just does not get converted into oxaloacetate by pyruvate carboxylase to keep the TCA going? 🙄

[@allentristen]

You can't keep TCA going without acetyl-CoA

[@bini9462]

I think high NADH/NAD+ ratio in alcoholics favors Pyruvate conversion to Lactate. And also high NADH/NAD+ ratio favors OAA conversion to malate so even if OAA is made from Pyruvate it may be converted to Malate right away. Acetyl coA is available from beta oxidation but there is depleted Oxaloacetate stopping the TCA cycle. Correct me if I'm wrong

[@bini9462]

And one more thing, in PDH deficiency the problem is not OAA deficiency but acetyl coA deficiency not getting made from Pyruvate specifically from glucose. To make up for it acetyl coA must be produced from fats. That's why high fat diet and ketogenic diet with low intake of carbohydrates is the treatment for PDH deficiency to make acetyl coA from beta oxidation so as to continue the TCA cycle.

[@nganguyenthanh4952]

😂

[@j7ndominica051]

The name pyruvate suggests that it could burst into flames at any point in time and make man into a pyre.

[@wicterwterr4245]

Fabulous - You have a God gifted ability too ahah

[@akarsh_24]

1

[@ayushkatare8080]

Seriously....it is this simple ??

[@Kirkmichals]

monetize

[@paulocl2]

Not carbon molecules, carbon atoms.

[@DirtyMedicine]

irrelevant for clinical purposes, but you are correct

[@nganguyenthanh4952]

​@@DirtyMedicine❤

[@youwhat.]

Thank you!

[@Alchemist_171]

Thank you!