Glycolysis

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  • เผยแพร่เมื่อ 22 เม.ย. 2020
  • ​​SUPPORT/JOIN THE CHANNEL: / @dirtymedicine
    My goal is to reduce educational disparities by making education FREE.
    These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
    For educational purposes only; NOT medical or other advice.
    Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
    Opinions are entirely my own.

ความคิดเห็น • 206

  • @turrlerabbit4884
    @turrlerabbit4884 4 ปีที่แล้ว +367

    Thank you so much for this. i'll definitely donate the second i stop being a broke student

  • @ogwangfrancis3608
    @ogwangfrancis3608 2 ปีที่แล้ว +231

    You are chosen by God to save medical students or biochemistry students. After attending three lectures of glycolysis and gluconeogenesis I didn't understand but your few minutes videos have made me understand. Long live

  • @marial1217
    @marial1217 3 ปีที่แล้ว +136

    When Dirty said "love you" at the end, I felt that. Love you too SO MUCH lol. Thank you, Dirty. I've gained a new appreciation of Biochemistry (and tbh, medicine in general) thanks to you. You're awesome.

  • @maxbilo6191
    @maxbilo6191 2 ปีที่แล้ว +124

    1:08 Glycolysis Overview
    3:15 Entire Glycolysis Pathway
    4:04 Glucokinase
    4:59 Hexokinase
    6:49 Rate Limiting Enzyme (PFK-1)
    7:44. PFK-1 Regulatory Mechanisms
    10:45 PFK-2 Regulatory Mechanisms
    12:20 Pyruvate Kinase
    12:53 Glycolysis Overview Final Chart

  • @1004hl
    @1004hl 3 ปีที่แล้ว +72

    I was so confused about the fructose 2,6 bisphosphate part until I watched this video. It cleared up all my confusions within a couple minutes. Thank you so much for your videos and saving me hours of frustration!!

  • @luabastos1493
    @luabastos1493 10 หลายเดือนก่อน +8

    Your videos have proven to be not only simple but also highly comprehensible, allowing me to successfully pass my biochem test. Thank you so much!

  • @nicolebinayug9188
    @nicolebinayug9188 4 ปีที่แล้ว +9

    you really helped me to understand this better than i ever imagined. i’m struggling reading its module bc our prof did not manage to discuss this due to quarantine & thank you omg you’re a life saver!!

  • @waybeyondtheblue434
    @waybeyondtheblue434 2 ปีที่แล้ว +4

    your videos are a gift from heaven!! I'm a student from germany, and sadly there are very few good videos in my language on this topic, and yours help me so so much!! Keep up the good work!

  • @somiomer3503
    @somiomer3503 ปีที่แล้ว +1

    Thank you so much dude. When I get to the US I'll definitely donate a lot because you helped me A LOT!
    YOU'RE THE BEST.

  • @vincefox8
    @vincefox8 4 ปีที่แล้ว +11

    You literally read my mind! Searched for glycolysis on your channel before bed, didn't find it, was sad, and then woke up to a brand new video on exactly what I needed!! Thank you!!

  • @zukagavasheli9262
    @zukagavasheli9262 2 ปีที่แล้ว +4

    you have no idea how thankful i am of yours, on behalf of all medical students thank you for these easy explanatory videos.

  • @Mayavee617
    @Mayavee617 7 หลายเดือนก่อน

    Thank you , you are a life saver. To the point as always,
    I can’t thank you enough!❤
    Wish for the best in every aspect !

  • @uniteUsk
    @uniteUsk 2 ปีที่แล้ว +4

    your 15min lesson just saved me in biochemistry. Thanks man your a life saver

  • @JustinMoreira
    @JustinMoreira 2 ปีที่แล้ว +41

    You inspired me to come up with this one.
    Difference in the relationship between hexokinase and glucokinase:
    "Hexokinase asks for Help"

    • @jax40001
      @jax40001 ปีที่แล้ว +2

      and Glucokinase Gives help

  • @user-er6et9qo8w
    @user-er6et9qo8w 5 หลายเดือนก่อน +2

    This playlist is better for biochem than boards and beyond or anything else out there. Absolute legend, thank you.

  • @daughteroftheking3220
    @daughteroftheking3220 ปีที่แล้ว +3

    I wish we could give you all our tuition. You are literal God-sent to us to save us from misery, mental-breakdowns,and final cramming for a test. Thank you doesn't even do you enough justice!!

  • @yuta2349
    @yuta2349 ปีที่แล้ว

    This channel is seriously the best for understanding topics of med school

  • @nasrudinabdi1635
    @nasrudinabdi1635 5 หลายเดือนก่อน

    You have done great service for humanity. God bless you

  • @evelynn3941
    @evelynn3941 หลายเดือนก่อน

    God bless you, you're the only youtuber that makes it easy for me to understand.

  • @sunshine-bj8ih
    @sunshine-bj8ih 3 ปีที่แล้ว +51

    You were called to teach. Thank you!

  • @lindembergsilveirafilho1842
    @lindembergsilveirafilho1842 2 ปีที่แล้ว +1

    Your explanation is simply outstanding. Thank you

  • @rajmukhopadhyay4837
    @rajmukhopadhyay4837 3 ปีที่แล้ว +8

    This is an excellent video with excellent analogies that makes it super simple to understand. One extra detail to note here is that Pyruvate Kinase can also be activated by F16BP (+ feedback). I believe this was mentioned in Kaplan MCAT Biochemistry.

  • @lovedazzle95
    @lovedazzle95 5 หลายเดือนก่อน

    Dirty thank you so much. You a literally saving my life right now.

  • @justinarnold3951
    @justinarnold3951 2 ปีที่แล้ว

    How did you manage to make understanding 2,6-BP sooo easy?!?! What a life saver

  • @chloesworld2083
    @chloesworld2083 ปีที่แล้ว +1

    Thank you so much for creating these videos! It's honestly a great help for Biochemistry students like myself. :)

  • @lailaaljazairia7884
    @lailaaljazairia7884 ปีที่แล้ว

    Thank you so much for these videos you have no idea how many students you are saving

  • @BryanBjay
    @BryanBjay 3 หลายเดือนก่อน

    GOD BLESS YOU!!!! This is all that I need. Just what I need to know!

  • @ramshamahmood6413
    @ramshamahmood6413 4 ปีที่แล้ว +1

    Thank you for breaking it down, and making it easier for me to understand. Love your work!

  • @VampireDiariesBiebs
    @VampireDiariesBiebs 3 ปีที่แล้ว +2

    thann you for the entire biochem playlist!

  • @bhavanigaddameedhi8870
    @bhavanigaddameedhi8870 2 ปีที่แล้ว

    you're just awesome and thanksss for making the most tough parts easy

  • @shriyamahapatra
    @shriyamahapatra 3 ปีที่แล้ว +1

    Sir urs explanations are just awesome... Respect for u sir🙏

  • @zilanayhan7864
    @zilanayhan7864 3 ปีที่แล้ว +1

    Thank you for a nice and clear lecture!

  • @Skyguy19
    @Skyguy19 10 หลายเดือนก่อน

    Not all heroes wear capes, you're one. Thank you

  • @umairjaved4755
    @umairjaved4755 3 ปีที่แล้ว +8

    The min I pass my steps , I'll start donating IA....Thank u so much brother♡

    • @avslayfar1231
      @avslayfar1231 2 หลายเดือนก่อน +1

      have you donated yet?

  • @kiruthikabalasubramani8874
    @kiruthikabalasubramani8874 4 ปีที่แล้ว +1

    One person who focus on clear understanding and of course on dirty exam questions... 😂...Thank u so much

  • @yana-marisaedwards1765
    @yana-marisaedwards1765 2 ปีที่แล้ว +2

    Thank you so much for your videos! I know you've heard this before but you just saved me!!

  • @wisercommunication4791
    @wisercommunication4791 ปีที่แล้ว

    Amazingly explained ! Thank you so much

  • @elsielc6826
    @elsielc6826 3 ปีที่แล้ว +5

    almost thinking of giving up medicine, not until i discovered your channel. Thanks Dirty!

  • @SK1MD
    @SK1MD ปีที่แล้ว

    This is so great!! Thank you so much!! God bless!!!😃❤

  • @najumudhina.m.k3966
    @najumudhina.m.k3966 3 ปีที่แล้ว +2

    PFK 1 & PFK 2 part is best explained. Awesome superb🤗🤗

  • @shabbirahmad7015
    @shabbirahmad7015 3 ปีที่แล้ว +1

    my dude you are so freaking amazing

  • @shreyaveldurthy
    @shreyaveldurthy 2 ปีที่แล้ว

    You are a life saver! Thank you so much

  • @wicterwterr4245
    @wicterwterr4245 2 ปีที่แล้ว

    Thank you so much - It was a great explaination!

  • @dramgcastillo
    @dramgcastillo 3 หลายเดือนก่อน

    I promise that when I get my licence in the US and get a job or match, I will unite to your channel and pay... tanks for these. You and Ninja Nerd are saviors

  • @michellechavez970
    @michellechavez970 2 หลายเดือนก่อน

    You’re the best! I wish you were my professor, thank you for your help!

  • @thextractor53
    @thextractor53 4 ปีที่แล้ว

    Thank you so much!!!

  • @stevejonan
    @stevejonan 3 ปีที่แล้ว

    Great job, very useful lecture

  • @xaaboopinkly
    @xaaboopinkly 4 ปีที่แล้ว

    Thank you soooooooo much!

  • @diandrad406
    @diandrad406 ปีที่แล้ว

    After 7 years, I finally understand Glycolysis!! Blessss

  • @emmanuelflourish-morris4073
    @emmanuelflourish-morris4073 ปีที่แล้ว

    Thanks for making this very easy to understand and remember.

  • @dvperez14
    @dvperez14 ปีที่แล้ว

    I am not sure what you are doing now in life, but you are such a blessing! God bless you , protect you and keep you safe and nourished in the years ahead in Jesus name. You are such a blessing and I am actually loving this instead of HATING it like i used to!!

  • @alaanasr6327
    @alaanasr6327 8 หลายเดือนก่อน

    Hi, Thanks alot for your content.
    do you have pdfs or slides?

  • @missbailey7280
    @missbailey7280 11 หลายเดือนก่อน

    I love your videos I have been struggling to get the big picture of everything and have watched a ton of videos I should have found this earlier 😢😢 thank you ❤❤

  • @Mariamhamwi
    @Mariamhamwi ปีที่แล้ว +1

    Do you think your biochem videos + Uworld is enough? I will watch all your biochem videos and study them thoroughly. I have my rotations so I have to be time-efficient with my studying

  • @mspinkdomi
    @mspinkdomi 3 ปีที่แล้ว +24

    Damn I'm in crunch time mode freaking out and this just made me understand this shit in less than 10 min 1.75x speed love you dirty

  • @user-cd8xd1cm6i
    @user-cd8xd1cm6i 4 ปีที่แล้ว +1

    Thank you!

  • @TheRealBlackPanda
    @TheRealBlackPanda 3 ปีที่แล้ว

    This dude is the plug for all things biology

  • @fatimahah6707
    @fatimahah6707 หลายเดือนก่อน

    Wow.
    Thank you soooo much.

  • @srana5049
    @srana5049 3 หลายเดือนก่อน +1

    Thank you so much dirty medicine. I recently passed my step 1 exam and all your videos were of great help in my step 1 journey. Thanks

    • @muzamara
      @muzamara 3 หลายเดือนก่อน

      Is the real deal similar to UWorld, Free 120 or NBME?

  • @oliwiapy9545
    @oliwiapy9545 4 ปีที่แล้ว

    Thank you so much❤️

  • @innominadojustis2224
    @innominadojustis2224 3 ปีที่แล้ว +4

    I try Physeo, Prixorize, USmle rx express videos, BnB, but it was YOU : OUR USMLE KING DIRTY MEDICINE who explain it simple and easy, GOD BLESS YOU i want to be like you👏🏻👏🏻👏🏻👏🏻

    • @Mariamhamwi
      @Mariamhamwi ปีที่แล้ว

      Did biochem videos feel sufficient to solve biochem well?

  • @VampireDiariesBiebs
    @VampireDiariesBiebs 3 ปีที่แล้ว +1

    seriously thank you so much

  • @sole23md
    @sole23md 4 ปีที่แล้ว +2

    thank you for posting this, stuck in the house trying to learn from harpers is much harder than this! great help

  • @drjeniferpreethi9305
    @drjeniferpreethi9305 3 ปีที่แล้ว +1

    God bless this channel

  • @sahibkang2899
    @sahibkang2899 2 ปีที่แล้ว +1

    Great video! Thanks!

  • @babyfishyyy97
    @babyfishyyy97 ปีที่แล้ว

    This help A LOT! Thank youu! ❤❤

  • @rakeshgoud5144
    @rakeshgoud5144 2 ปีที่แล้ว

    Thank you ! 💞🥰

  • @peskyseagull
    @peskyseagull 4 ปีที่แล้ว +37

    Oh yes, Daddy Dirty going high yield

  • @gentlegenius6778
    @gentlegenius6778 2 ปีที่แล้ว

    Really helpful
    Thank you sir
    God bless you

  • @artem44038
    @artem44038 4 ปีที่แล้ว

    man you'r incredible

  • @dr.fatemaomran3105
    @dr.fatemaomran3105 8 หลายเดือนก่อน

    Perfect teaching ever

  • @ayeshakhan6795
    @ayeshakhan6795 3 ปีที่แล้ว

    Thank you!!!

  • @ruemubarak1702
    @ruemubarak1702 3 หลายเดือนก่อน

    Thank you.... thank you... thank you

  • @fatimamemon1996
    @fatimamemon1996 ปีที่แล้ว

    Thank you so much I love your videos

  • @aletheiathreskeia1844
    @aletheiathreskeia1844 2 ปีที่แล้ว

    How I wish these kinds of channels existed 10 yearas ago when I was still a medical student....

  • @prernasoni5386
    @prernasoni5386 2 ปีที่แล้ว +1

    Just wow🔥

  • @lidiateshome819
    @lidiateshome819 2 ปีที่แล้ว

    Ur awesome! How you easily break down concepts is mesmerizing!!

  • @davidrios1492
    @davidrios1492 4 ปีที่แล้ว

    Bombbbbb. Thank you!!!!

  • @zachary.ramsumair
    @zachary.ramsumair 2 หลายเดือนก่อน

    rate liming and regulatory enzymes . WOW thanks

  • @MohamedOsama-ny7ix
    @MohamedOsama-ny7ix 3 ปีที่แล้ว

    you are a legend mate

  • @sanverse6807
    @sanverse6807 20 วันที่ผ่านมา

    Sir you're here saving lives ❤❤

  • @edgarmartos6016
    @edgarmartos6016 3 ปีที่แล้ว +4

    It is also high yield to know that conversion of glyceraldehyde 3 phospate into 1,3 biphosphohlycerate needs NAD+ as cofactor of glyceraldehyde 3 phosphate dehydeogenase. This is something that has been asked in uworld in the context of alcohol ketoacidosis where there is NAD depletion (due to NADH acummulation) or LDH deficiency, where you are NAD depleted, as in normal conditios the conversion of pyruvate into lactate uses NADH and finally converts into NAD to be used in this specific glycolisis step. In this 2 scenarios you would not have NAD, thus glycolisis can not procede anymore as there would not be any cofactor for G3P dehydeogenase, explaining why patients with alcoholic ketoacidosis and LDH Deficiency have hypoglycemia.

  • @christinac1195
    @christinac1195 2 ปีที่แล้ว

    i wish everyone taught like you~ big picture first! thank youuuuuuu

  • @thewellbeingqueen_
    @thewellbeingqueen_ 3 ปีที่แล้ว

    thank you. great vid

  • @themyofascialclinic1356
    @themyofascialclinic1356 4 ปีที่แล้ว

    Thank you! :)

  • @Alex-ov4xl
    @Alex-ov4xl 2 ปีที่แล้ว

    Awesome video. thanks

  • @Afife1002
    @Afife1002 2 หลายเดือนก่อน

    ❤❤❤❤❤ you are the best.

  • @SarahAlhamdan
    @SarahAlhamdan ปีที่แล้ว

    you saved my life, thank you

  • @rimzimbajoria5822
    @rimzimbajoria5822 2 ปีที่แล้ว

    Thank you ur videos are really very helpful... Waiting for more such videos ☺️☺️❣️

  • @mary.b92
    @mary.b92 3 ปีที่แล้ว

    I like your videos, thank you

  • @SteveSaxony
    @SteveSaxony 7 หลายเดือนก่อน

    is this enough for step 1? or should we study it more in depth? cuz other than this i dont remember anything about glycolysis.

  • @FatimaMakesStuff
    @FatimaMakesStuff 8 หลายเดือนก่อน

    thank you

  • @Rayray.johnson00
    @Rayray.johnson00 3 หลายเดือนก่อน

    Very informative, much appreciated

  • @kshanikdayaram3984
    @kshanikdayaram3984 4 ปีที่แล้ว +6

    i think i might name my firstborn after you thank you so much

    • @b.u.8709
      @b.u.8709 2 ปีที่แล้ว

      @V LOOOOOOL!!!

  • @eyram8396
    @eyram8396 ปีที่แล้ว

    you are just amazing❤

  • @samsonridge4526
    @samsonridge4526 2 ปีที่แล้ว

    i hear every word from you very very well

  • @josemiguelgomezmunoz3445
    @josemiguelgomezmunoz3445 ปีที่แล้ว

    Big thanks!

  • @NoorjahanJaganath
    @NoorjahanJaganath ปีที่แล้ว

    love you...
    you are so amazing

  • @abhijeethreddy7333
    @abhijeethreddy7333 ปีที่แล้ว

    U save my time .. Thank you 😊

  • @whitecoatandmore1744
    @whitecoatandmore1744 3 ปีที่แล้ว

    Please upload gluconeogenesis!!!! Thanks a lot for not making biochem a nightmare for me!