Currently prepping for my biochem final in grad school and just wanted to say this channel has helped me so much this semester! I think I will frame all of the drawings I made from these videos. Thank you thank you thank you!
Im a medical student and ur videos have really helped me alot thank you for these awesome videos now i really understand biochemistry cuz of you :) Also i will appreciate if can make videos on proteins metabolism as soon as possible thanks :))
you are honestly the reason why i love biochemistry! i actually hate and despise chemistry all my life but all your videos are so great in explaining every process in our body and right now my favourite and top scored subject in medschool is biochemistry! T_T Thank you so much you're a life changer really
I am medicine student and I am preparing for my exam by your videos I had watched the 30vvideos of biochemistry and until now I didn’t found any one better than you in explaining biochemistry
Yo showed the beautiful side of biochemistry, it makes me love it, and it is unforgettable from my memory after understanding it. Thank you🌸. I pray to God to comfort your heart and make you happy as you do with us 🤲💕
I'm first year medical student in Brazil, thanks a lot for this biochem playlist!! We both are visual learners so it's easy to understand your explanations! :)
Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.
You're completely correct. CoA is bound by a thioester bond and there is no carboxyl group at the end of the fatty acid chain. The second oxygen comes from the glycerol chain itself where it forms an ester bond between the glycerol chain and the fatty acid chain allowing the CoA-SH to dissociate. Also to nit-pick a tad, What he calls a "DAG" is only technically incorrect in that "DAG" refers to the dephosphorylated form of Phosphatidic acid. It's not a huge deal conceptually because he still does a great job at explaining the flow of events for TAG synthesis but since DAG itself is involved in other metabolic pathways and is itself a second messenger in cellular signaling cascades, I thought it worth it to know that DAG itself is a bit more distinct from PA.
I have my Biochemistry exam on monday and i've been studying it since February :(, your videos helped me to love and learn this subject, thank you so much!
The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.
Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great. Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.
Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?
@ninjanerdscience We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds. and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG. Anyways, Thank you for this amazing video. Love to revise through this.
you're literally a Harper's Heroes as your shirt says...I can't understand the book hahaha thanks alot man! i dont skip ads because i love this channel and I want you to keep growing this channel!
When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD
@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown
I think we can call the lysophosphatidic acid MAG only if we get to dephosphorylate it and similarly phosphatidic acid once dephosphorylated is when we get DAG if not so they are different structures.However, the lecture is great.
I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?
bc the O is already drawn in the Glyceral-3-phosphate shouldn't it be PO3 ^-2 instead? Anyways thank you for these videos, i have such a hard time with Biochemistry and these are a lifesaver
greetings, in this lecture, you said that the 2nd fatty acid that is to be added to the glycerol backbone has to be unsaturated, so what about the 1st fatty acid that is to be added? does the 1st fatty acid have to be saturated fatty acid?? thank you in advance.
for each fatty acid, the end side of the long carbon chain should be -CH2CoA? also, this is an esterification, the hydroxyl group should react with carboxyl group ,thus the oxygen minus should act as electron donor. Right？
Hello, thank you for making this useful videos for us, I have a question about this lesson: at the beginning we added a phosphate to the Glycerol using Glycerol kinase then before adding fatty acid number 3, by means of Phosphatidic phosphatase we got rid out of that phosphate, so what is the function of that phosphate group?
I think you might just be the reason I'll pass my Biochemistry exam.
I will forever be thankful.
Currently prepping for my biochem final in grad school and just wanted to say this channel has helped me so much this semester! I think I will frame all of the drawings I made from these videos. Thank you thank you thank you!
Im a medical student and ur videos have really helped me alot thank you for these awesome videos now i really understand biochemistry cuz of you :)
Also i will appreciate if can make videos on proteins metabolism as soon as possible thanks :))
Ur the foundation of my Knowledge....thanks sir for making medschool interesting
Zach you have helped millions of students in making MBBS easy ❤
I wish there was no attendance necessary in my college!! This channel is enough to learn biochemistry!! ❣️🙏 Lots of love from india 🇮🇳🇮🇳
you are honestly the reason why i love biochemistry! i actually hate and despise chemistry all my life but all your videos are so great in explaining every process in our body and right now my favourite and top scored subject in medschool is biochemistry! T_T Thank you so much you're a life changer really
+cupcakechip So happy to help! Glad we were able to make you enjoy it!
I am medicine student and I am preparing for my exam by your videos I had watched the 30vvideos of biochemistry and until now I didn’t found any one better than you in explaining biochemistry
I honestly stopped going to classes. I just watch your videos! God bless you!!!!
As a medical student your videos really help me a lot. Biochemistry is so complicated and I learn it more easier than lectures because of your videos.
You don’t know what your existence means to us….. we love you thank you….
It’s really satisfying to take nap in biochem lectures after attending ninja….
Yo showed the beautiful side of biochemistry, it makes me love it, and it is unforgettable from my memory after understanding it. Thank you🌸.
I pray to God to comfort your heart and make you happy as you do with us 🤲💕
I shall never attend lecture ever again
sir please zoom out the camera in the end so that we could take a screenshot of the lectures.
thanks
Agreed
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@@ishaanchandorkar becuz only Indians and Pakistans call people sir and speak to them as if they are superior then themselve.
@@saeeda4517 Wow... it's amazing how you have such stupid stereotypes... Grow up ffs
@@saeeda4517 moron
I'm first year medical student in Brazil, thanks a lot for this biochem playlist!! We both are visual learners so it's easy to understand your explanations! :)
Very lovely video, thank you so much for you content Ninja Nerd. However I do think the 3 fatty acyl-CoA you have made in the beginning is a little bit misleading, since it should be CoA-SH bound to the carbonyl group with a thioester bond right? The CoA should be drawn in the other end and the Oxygen shouldn't be present right? Please correct me if I'm wrong.
You're completely correct. CoA is bound by a thioester bond and there is no carboxyl group at the end of the fatty acid chain. The second oxygen comes from the glycerol chain itself where it forms an ester bond between the glycerol chain and the fatty acid chain allowing the CoA-SH to dissociate. Also to nit-pick a tad, What he calls a "DAG" is only technically incorrect in that "DAG" refers to the dephosphorylated form of Phosphatidic acid. It's not a huge deal conceptually because he still does a great job at explaining the flow of events for TAG synthesis but since DAG itself is involved in other metabolic pathways and is itself a second messenger in cellular signaling cascades, I thought it worth it to know that DAG itself is a bit more distinct from PA.
Ur like osm and ur lectures literally helping me alot can't imagine my biochemistry with ur channel
Thank you sooo much😊
I swear this guy saved me, I'm extremely grateful for this channel 🙏
I still cant believe that this is free.. thank you sooo much
Thanks alot from nigeria 🇳🇬
One of the best doctors I have ever seen, Your videos have really helped me sir and keep it up
I have my Biochemistry exam on monday and i've been studying it since February :(, your videos helped me to love and learn this subject, thank you so much!
how did it go?
@@theaizere really well! 27/30💕
@@camillamicucci1155 that’s wonderful! Great job. aspirational
The ⁻O-CO-(CH₂)ₙ-CH₃-CoA notation is a bit weird, I guess you mean H₃C-(CH₂)ₙ-CO-S-CoA or something like this? Usually, there is no 5-bond-carbon and the FA-synthesis should result in something like R-CO-S-CoA.
Yes.. the notation is not weird. I would call it wrong. It misleads. H₃C-(CH₂)ₙ-CO-S-CoA this one is correct.
I almost waste 4 hours looking for someone I can understand on and finally the legend reveals itself 👑
Biochemistry become my favorite subject after watching your videos 😃❤️
Same here
YOU ARE MY HERO!!!!!!
Great video as always. There are a few things I wish you'd mentioned. First of all I only learned later that Glycerol 3-phosphate is made directly from DHAP via Glycerol 3-phosphate dehydrogenase. I don't believe you mentioned that. Also a mention about glyceroneogenesis would have been great.
Anyway. Thanks for the video. Maybe I'll actually survive Biochem with this.
+SeptimusCreed thank you very much I hope the video was able to help. Best of luck in your future endeavors
OMG THANK YOU, you have made a subject I dread easy to learn and enjoyable
This video made it so so clear thank you !
You make it so simple ❤ thats awsome 🐼 thank you it really helped 💙
Questions: Is the second fatty acid in a TAG always an unsaturated fatty acid? Does this mean that fatty acids 1 and 2 will always be saturated? Furthermore, are the answers important in the context of nutritional ketosis?
So happy I watched the fatty acid synthesis and oxidation videos you advised!
You’re the king of biochem
Loved this video! You explained this process very well and I was able to make sense of it all. Thank you :D
i really like how you explaining the things which i can understand it clearly. thank you for the great videos!!!
I'm in lovee with biochemistry bcs of ur vidéos broo
@ninjanerdscience
We cannot call MAG (Monoacylglycerol) and DAG (Diacylglycerol) without removing the phosphate group attached to the respective compounds.
and in Step #3 conversion of Phosphatidic acid to DAG should take place first using phosphatase enzyme and in the next step we add the last Fatty acyl CoA to make it TAG.
Anyways, Thank you for this amazing video. Love to revise through this.
It can be called a DAG phosphate or a MAG phosphate
you're literally a Harper's Heroes as your shirt says...I can't understand the book hahaha thanks alot man! i dont skip ads because i love this channel and I want you to keep growing this channel!
Thankyou sir. This vedio is very easy to understand .Very nice explanation. 👍
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Another great video as always!!
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Awesome videos! I felt like I'd never get metabolism. Thank God I found you💕.
Please male vid. About nucleotide metabolism and phospholipids.
Great work, thanks for every video
You are a literal life saver amazing video!!
When a phosphate group linked to a glycerol molecule its formula become C3H7O3PO3-2, you guys add an additional oxygen atom and a negative charge. The rest is awesome thank you :DD
pKa1=1.0, pKa2=8.0 for phosphatidic acids, so at physiological pH, almost all are singly-protonated, that is -HP04-1
@@johnpowell9174 I think the main issue he is pointing out is that it should be PO3 linked to the glycerol backbone (resulting in O-PO3), instead of the O-PO4 that is shown
@@seanluong6064 Agreed.. There a structural formula issue
Speechless!!!😮😍😍😍❤❤❤❤❤❤❤❤
I think we can call the lysophosphatidic acid MAG only if we get to dephosphorylate it and similarly phosphatidic acid once dephosphorylated is when we get DAG if not so they are different structures.However, the lecture is great.
that was absolutely fantastic explanation for that process
thank you so much 🧡🧡🌹
Thank you👍
thanks so much, this is very helpful. may God bless u
We love you thanks a million just keep going
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Most thankful from Jordan
Man,you're better than my lecturers, what am i paying my money for when i can study online with you
thank you very much Zack it was so helpful as everytime
Benefiting medical students is a great jop ❤
My Goat❤
Really we owe you a lot sir
Good Job ❤
Why should the second fatty acid necessarily be unsaturated??
great lecture u made everything clear thanks sir
+zena said You’re welcome!
Thanx sir for ur best explanation
Many thanks to you! You are great! Keep up your good job!
Good job Sir ❤️
I really like these videos 😍😍😍
I’m watching this after five years and thaaanks❤ just a question.. you told the fatty acid chain that is gonna attach to carbon No. 2 in glycerol should be unsaturated but how simple saturated triglycerides are made? Or we don’t have simple saturated triglycerides naturally?
bc the O is already drawn in the Glyceral-3-phosphate shouldn't it be PO3 ^-2 instead? Anyways thank you for these videos, i have such a hard time with Biochemistry and these are a lifesaver
Toooo good explanation.... Thanks a lot brother👦
You saved my life
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Thanks a lot ❤
Very nice explained .useful to me👍
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greetings, in this lecture, you said that the 2nd fatty acid that is to be added to the glycerol backbone has to be unsaturated, so what about the 1st fatty acid that is to be added? does the 1st fatty acid have to be saturated fatty acid??
thank you in advance.
Thank you. It really helped a lot!!!
Omw this is so understandable ...please please please do a protein metabolism video series
Thank you sir for helping us
you are the best thing in the world i love you so much thank you vey much i got it all thanks again !!
Thank you 🙏🏼 great explanation 🧡
Thank you!!!
What chooses which types fats are added to the glyceride base. Fully saturated fats are flatter and the resulting try g is more dense.
Wow, what an informative video!
for each fatty acid, the end side of the long carbon chain should be -CH2CoA?
also, this is an esterification, the hydroxyl group should react with carboxyl group ,thus the oxygen minus should act as electron donor. Right？
Hello, thank you for making this useful videos for us, I have a question about this lesson:
at the beginning we added a phosphate to the Glycerol using Glycerol kinase then before adding fatty acid number 3, by means of Phosphatidic phosphatase we got rid out of that phosphate, so what is the function of that phosphate group?
The video is amazing. But regarding the glycerol 3-P wasn't it supposed to be PO3 2- and not PO4 3- ?
So good!
Very useful. Tanks.
my hero