I just wanna say that these videos are priceless for me. Instead of reading the textbook and feeling sleepy, now im watching and learning and it's much more effective for me to absorb new knowledge. Thanks so much
I found your channel when I was desperate to learn something about facial nerve for anatomy lessons and I discovered that you teach biochemistry too! I can't be more grateful for what you do for medicine students all over the world
Having teachers like you nowadays is kind of impossible! Thank you for saving our lives and all the efforts that you put on those great videos you are such a HERO even though English isn't my first language and I really struggle with it, but you made everything look easy. Thank you so much.
Your videos are very detailed, easy to understand and informative. You make the pathways easier to understand. Thank you your videos are saving my grade in Macronutrients!!
I am a university student in Sri Lanka. I couldn't get any idea about FA synthesis before but now I have a perfect understanding about this. Thank you very much
Excelent explanation! Just a small obsrvation at 2:18 Citrate is transformed to Isocitrate by the catalysis of Aconitase enzyme, but this is not the enzyme that is regulated. When there ATP concentration is high, Citrate Synthase is inhibited and Isocitrate accumulates, and since that the reaction from Citrate to Isocitrate is reversible, Citrate starts to accumulate as well.
I have been grappling with this all week, just trying to understand FA synthase. This is just gold. Plus it's been recently updated! How perfect! All the powerpoint slides I have been given at med school was just useless... Thank you and congratulations on your website launch!
It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!
no words, just emotions. I finally understood this topic, of course with the help of the greatest professor on our Planet- professor Zack Murphy. Infinite Love and Respect from me to Ninja Nerd channel
Thank you so much! it would be extra excellent if u could show the Chemical structure of the reaction species of addition of old Malonyl chain with new Malonyl residue of ACP. But when I see that step 2nd time and draw the chemical structure by myself and thought of it ,,I just understood that!!! U r such a Nicer Human!!!
I could never express how much these videos help me! You are such a joy to watch and I've never had so much fun learning for my exams :) Love from Germany
I just covered a whole lec in just 37 minutes man you are awesome❤❤ and i just wanted to mention it's actually 3-hydroxy ACP dehydratase rather than what you wrote on the board and i think you even corrected it in the end mid-explaining
Thanks for the great video! Small notice: ATP is negatively regulating Isocitrate Dehydrogenase, not the Aconitase. You explained it correctly in part 1. Cheers.
came here from ur website just to comment and say- the way you get excited about biochem (those nadphs) is like a kid in a candy store! thank you and ur team for putting in so much effort for all of us out here!
This is really amazing. I hate watching videos that are more than 5mins but I really love this explanation and watched both videos. Thanks a lot for these explanations.
this is the first time i smile while i study, doesn't mean i don't like the material but i am just focused. but his enthusiasm and smiling laughing. i like how he mention when the NADPH are used in the 5th step of FA synthesis, he's like "they're comin in baby"
am a first year med student ,i have been studying this thing on biochem book but i havent be understanding it bt after i have watched this videos .everything looks easier,i thank you prof zach together with your team
hey Zach, in the reaction catalyzed by Condensing enzyme, the CO2 is released from malonyl bound to ACP domain and not the acetyl group ..it is the same CO2 added to acetyl coA by ACC previously . so there should be 2 red and 2 blue carbons in step 3
Thank you, I was about to comment this too - the extra CO2 (acetyl to malonyl) is there in the first place to make the pathway, specifically the condensation step, thermodynamically viable. The CO2 that "leaves" the cycle each turn during condensation is ALWAYS from an incoming malonyl-CoA because of this specific reason :) The resulting palmitate (the product after its hydrolysis from FAS I) therefore has C15 and C16 from the original ACETYL-CoA, the rest comes from these "temporarily carboxylated" building blocks, malonyl-CoAs :) Hope that made sense! Anyways, I absolutely love these videos. I'm in the final stages of cramming for my very last exam for my PhD in biochemistry and these videos always give me an immense motivational boost... and I can listen to them anywhere, too! Good thing I have discovered this channel before it's too late. NinjaNerd, prof. Zach, you are a lifesaver :)
Thank you sir. Two idea different from my book 1. The four carbons of acyl group , two from aceyl coa and two from malonyl coa, while the carbon removed is the one added by acetyl carboxylase enzyme. 2. The condensing enzyme is called ketoacyl synthetase Thank you sir
Hi Ninja Nerd! Thank you for being out there and teaching ❤️ This video was super helpful but I just wanted to let others know when we “pluck off” the 1st Carbon due to Decarboxylation , it supposed to be the last one from Malonyl-CoA, not Acetyl-CoA😊
Thank you sir I'm gonna graduate. No questions about that. Your drawings tend to have everlasting impact on the way We understand. What a great channel. From Africa.👏👏👏
never getting tired of seeing how excited he is about teaching. wish more teachers were like him. he's the best!
thank you
❤
bro i might not even enjoy playing a game that i love as much as he does teaching. Truly a gem
ummmm okay
@@andrewmontoya8511boo!
I just wanna say that these videos are priceless for me. Instead of reading the textbook and feeling sleepy, now im watching and learning and it's much more effective for me to absorb new knowledge. Thanks so much
So trueeee🥹🥹🥹
This man is a hero!! Saving students one video at a time. Thank you for your work that continues to be discovered year after year🙏
i am a year one med student, thanks so much for these videos!! Wouldn't survive biochem without you!
I found your channel when I was desperate to learn something about facial nerve for anatomy lessons and I discovered that you teach biochemistry too! I can't be more grateful for what you do for medicine students all over the world
Bro watch his physiology vedios
this guy is a doctor synthase.
😅😅😅😅😅
This cracked me up ngl
Genius
😂😂
LMAO
I don't know how I would survive med school without you ,love how you explain in detail and make high yield videos
I physically had to pause the video for a break just to say how much I appreciate you man.
Having teachers like you nowadays is kind of impossible! Thank you for saving our lives and all the efforts that you put on those great videos you are such a HERO even though English isn't my first language and I really struggle with it, but you made everything look easy.
Thank you so much.
You deserve the Nobel price for this service. 👏👏👏❤️❤️
Nobel price is at least $100k. I agree.
agreed
honestly bng!
Thanks!
Thanks so much, Julie!
If Ninja nerd would not be there I would have pass my 5 year course in 7 years.. thanks a lot Ninja nerd ❤️
Love the way you explain things with so much excitement. I don’t even know how someone can keep so much information in his brain!
You're amazing brother. Really helping us med student here. You're the best Teacher we all dream to get in our Universities
Your videos are very detailed, easy to understand and informative. You make the pathways easier to understand. Thank you your videos are saving my grade in Macronutrients!!
3:58 pyruvate has 3 carbons, not 2... I've been doctor for 23 years and studying again all of these issues. Thanks a lot for your help in this process
I am a university student in Sri Lanka. I couldn't get any idea about FA synthesis before but now I have a perfect understanding about this. Thank you very much
Excelent explanation!
Just a small obsrvation at 2:18
Citrate is transformed to Isocitrate by the catalysis of Aconitase enzyme, but this is not the enzyme that is regulated.
When there ATP concentration is high, Citrate Synthase is inhibited and Isocitrate accumulates, and since that the reaction from Citrate to Isocitrate is reversible, Citrate starts to accumulate as well.
he said and explained it in part one
Dude, you’re a true blessing. You make my life so much easier in Biochemistry
I have been grappling with this all week, just trying to understand FA synthase. This is just gold. Plus it's been recently updated! How perfect!
All the powerpoint slides I have been given at med school was just useless...
Thank you and congratulations on your website launch!
I love how its so clearly taught. 37 mins and I understand everything.
It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!
Yess that 2 Cs from Acetyl stay in the ultimate fatty acid chain at the terminal end.
Makes sense if then every time another malonyl is added, it is decarboxylated. Thanks!
When I noticed, i was like, okay let’s read the comments 😄
@@arnabdas5883 you mean the side that isn't -COOH right?
You are correct. The teacher is teaching something that is WRONG. He should replace the tutorial video and reupload it correctly. 🤦♂️
This dude is actually a blessing, I love this channel!
Thank you so much for correcting this video! Needed this badly for an upcoming test. Much love ❤️
OMG! that's really cool you are being more and more organized, keep going, love it :)
no words, just emotions. I finally understood this topic, of course with the help of the greatest professor on our Planet- professor Zack Murphy. Infinite Love and Respect from me to Ninja Nerd channel
تعبت وانا اقول اسطورة، توفير وقت وجهد، الطب صار سهل
Professor Zach is truly a diamond in our lifes
Thank you so much! it would be extra excellent if u could show the Chemical structure of the reaction species of addition of old Malonyl chain with new Malonyl residue of ACP. But when I see that step 2nd time and draw the chemical structure by myself and thought of it ,,I just understood that!!! U r such a Nicer Human!!!
You are just Amazing!
I learn more from you lectures than from my actual modules, Keep it up
You make all topics easier and enjoyable , thank you
This man is every medic's joy and salvation.... if I finish med, would love to someday repay all these videos somehow.
this is amazing, I love learning biochemistry with ninja nerd❤
Thank you so much
I could never express how much these videos help me! You are such a joy to watch and I've never had so much fun learning for my exams :)
Love from Germany
You are really a gem 💎 to medical and biomedical students 👍
I just covered a whole lec in just 37 minutes man you are awesome❤❤ and i just wanted to mention it's actually 3-hydroxy ACP dehydratase rather than what you wrote on the board and i think you even corrected it in the end mid-explaining
Much love and appreciation to your content❤
Thanks for the great video! Small notice: ATP is negatively regulating Isocitrate Dehydrogenase, not the Aconitase. You explained it correctly in part 1. Cheers.
At step 10: IMO the leaving CO2 should be the one from the Malonyl, the Acyl group does not have oxidized carbons to release as CO2.
@@hmone yea I was just about to comment this lol
@@hmone yeah. in the next step too. to retain the OG 4Cs, the CO2 should evolve from the new malonyl group on ACP
I thank you from the bottom of my heart for making this an easy concept !🤩🤧
came here from ur website just to comment and say- the way you get excited about biochem (those nadphs) is like a kid in a candy store! thank you and ur team for putting in so much effort for all of us out here!
yall are fantastic!
This is really amazing. I hate watching videos that are more than 5mins but I really love this explanation and watched both videos. Thanks a lot for these explanations.
His passion and enthusiasm is fabulous 😀
the best teacher ever!!!!
Consistent, detailed, and comprehensive...thank you so, so much!
It's simply Amazing and mind-boggling of how you simplify the concepts for the learners.....hats off for the Nobel endeavour 👏👏👏👌🙌
Thankyou professor for making our med journey easier
this is the first time i smile while i study, doesn't mean i don't like the material but i am just focused. but his enthusiasm and smiling laughing. i like how he mention when the NADPH are used in the 5th step of FA synthesis, he's like "they're comin in baby"
dude this video is on fire
hey zack, i know you might never see this but, keep it up champ and If i made tomorrow's exam this good i'll donate you some money
great work . love you ninga nerd from sudan umst
Thank you Ninja Nerd. You're the real OG
Yeah ninja nerd it makes perfect sense and we enjoyed it❤😊❤
am a first year med student ,i have been studying this thing on biochem book but i havent be understanding it bt after i have watched this videos .everything looks easier,i thank you prof zach together with your team
Best video sir u r so hard working u explained even small points too
the strongest channel in medical history bro... much better than osmosis, kaplan and everything else... really GJ
I love you. My biochemistry final is in 1 day, and I am cramming my life away. Thank you brotha.
Love this guy. Favorite professor.
thank you so much. you are the only thing getting me through my biochemistry exams
I am out of words to appreciate and thank 😊🙏 you Ninja Nerd!
Much love from Uganda
Thank you so so much for being our saviour Zach. Very well explained, and you have got that talent. No doubt about it
Everything becomes easier after watching these videos.
God bless you, legend
As a kinetic-visual learner, this form of gradually adding to a picture is ideal for me!
Thanks alot!
Pyruvate has 3 carbons tho, not 2 (3:55).
I thought pyruvate was a 1-carbon molecule?????
@@1Dann123 glucose is a six carbon molecule which is split into two pyruvate so each pyruvate is 3 carbons. No CO2 is removed during glycolysis
@@annajoyoregan4744 Anna… I thought the multiple question marks would have tipped you off… maybe ninja has some videos on sarcasm you can watch!
You're the best teacher that I've ever had❤❤,
Thanks man.
What I do Without your Lectures !
Stay Blessed.
You are a life saviour for many of us 💕 lots of love for you professor. Thanks alot for such conceptual videos. May God bless you
hey Zach, in the reaction catalyzed by Condensing enzyme, the CO2 is released from malonyl bound to ACP domain and not the acetyl group ..it is the same CO2 added to acetyl coA by ACC previously . so there should be 2 red and 2 blue carbons in step 3
YESS exactly i was going to comment this!
I just thought the same thing and came to check the comments to see if there is anyone else who thinks like me :)
Thank you, I was about to comment this too - the extra CO2 (acetyl to malonyl) is there in the first place to make the pathway, specifically the condensation step, thermodynamically viable. The CO2 that "leaves" the cycle each turn during condensation is ALWAYS from an incoming malonyl-CoA because of this specific reason :) The resulting palmitate (the product after its hydrolysis from FAS I) therefore has C15 and C16 from the original ACETYL-CoA, the rest comes from these "temporarily carboxylated" building blocks, malonyl-CoAs :) Hope that made sense!
Anyways, I absolutely love these videos. I'm in the final stages of cramming for my very last exam for my PhD in biochemistry and these videos always give me an immense motivational boost... and I can listen to them anywhere, too! Good thing I have discovered this channel before it's too late. NinjaNerd, prof. Zach, you are a lifesaver :)
Just saying, your videos are really helping me understand stuff for my metabolism class in university
Your channel gives me hope that lessons can be fun and enjoyable
currently learning fatty acid synthesis and this is a life saver
this man is the reason i love biochemistry
This guy made biochemistry really interesting and easy to understand and remember.
YOU ARE SOOO AMAZING JUST KEEP GOING
Thank you sir. Two idea different from my book
1. The four carbons of acyl group , two from aceyl coa and two from malonyl coa, while the carbon removed is the one added by acetyl carboxylase enzyme.
2. The condensing enzyme is called ketoacyl synthetase
Thank you sir
This process is hella cool! Had fun learning it!!!
God brought this angel to earth to help students 🥺👌🏻
thanks for my A in biochem
He certainly deserves the Nobel prize 👌🏻💯 The hero Ninja nerd❤️👑👑👑
Amazing work NinjaNerd! Appreciate your videos!
Hi Ninja Nerd! Thank you for being out there and teaching ❤️
This video was super helpful but I just wanted to let others know when we “pluck off” the 1st Carbon due to Decarboxylation , it supposed to be the last one from Malonyl-CoA, not Acetyl-CoA😊
You deserve Noble prize 👏👏
Thank you sir I'm gonna graduate. No questions about that. Your drawings tend to have everlasting impact on the way We understand. What a great channel. From Africa.👏👏👏
Im so happy to have you guys 💗
When it all clicks ✨
This gotta be the perfect time that you uploaded this just a couple weeks ago thank you proff
Dude youre awsome i didnt think i could undrestand it but u made it look so easy thankuuuu
ilike the sound of the marker it make when zack opened it. soo satisfying haha
You deserve all the support professor ❤️❤️
I can understand biochemistry because of you
Thank u so much❤❤
This is magic, master this is magic.Like ı'm not studying, more like watching netflix.Thanks a lot really.
Fantastic, as always! You are a blessing! Thank you very very much!
So thankful for these lectures!!!!!!!!!!
Thank you so much Sir for making my concepts crystal clear about fatty acid synthesis
Glad you corrected part 2 because it had some errors on the old video. God Bless you
I have exam this friday and this was updated today hehe.. Thank you so much!
عاشت ايدك ❤
Well this is the hardest videos to understand but you’re doing amazing job I love your videos
I'm learning so much from you sir.You explain everything really well. 🤗💕
Best teacher ever