Metabolism | Fatty Acid Synthesis: Part 2 (Updated)
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- เผยแพร่เมื่อ 3 มิ.ย. 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/fat...
Join us for part 2 of this two part series on fatty acid synthesis. During this lecture we will be concluding our discussion on fatty acid synthesis. We will also be talking about how Malonyl-CoA is converted into 16 carbon fatty acids. We also talk about the main enzyme in this process called fatty acid synthetase and the different domains of the fatty acid synthetase. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #FattyAcidSynthesis #Metabolism
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3:58 pyruvate has 3 carbons, not 2... I've been doctor for 23 years and studying again all of these issues. Thanks a lot for your help in this process
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It seems you made a mistake. In 19:44 you said that 3 C atoms come from malonyl and 1 C atom from acetyl. According to Lippincott's 'Biochemistry' (2017) the atom in CO2 comes from malonyl, not acetyl, so eventually you get 2 C from malonyl and 2 C from acetyl. Cheers!
Yess that 2 Cs from Acetyl stay in the ultimate fatty acid chain at the terminal end.
Makes sense if then every time another malonyl is added, it is decarboxylated. Thanks!
When I noticed, i was like, okay let’s read the comments 😄
@@arnabdas5883 you mean the side that isn't -COOH right?
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Pyruvate has 3 carbons tho, not 2 (3:55).
I thought pyruvate was a 1-carbon molecule?????
@@1Dann123 glucose is a six carbon molecule which is split into two pyruvate so each pyruvate is 3 carbons. No CO2 is removed during glycolysis
@@annajoyoregan4744 Anna… I thought the multiple question marks would have tipped you off… maybe ninja has some videos on sarcasm you can watch!
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Thank you sir. Two idea different from my book
1. The four carbons of acyl group , two from aceyl coa and two from malonyl coa, while the carbon removed is the one added by acetyl carboxylase enzyme.
2. The condensing enzyme is called ketoacyl synthetase
Thank you sir
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currently learning fatty acid synthesis and this is a life saver
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hey Zach, in the reaction catalyzed by Condensing enzyme, the CO2 is released from malonyl bound to ACP domain and not the acetyl group ..it is the same CO2 added to acetyl coA by ACC previously . so there should be 2 red and 2 blue carbons in step 3
YESS exactly i was going to comment this!
I just thought the same thing and came to check the comments to see if there is anyone else who thinks like me :)
Thank you, I was about to comment this too - the extra CO2 (acetyl to malonyl) is there in the first place to make the pathway, specifically the condensation step, thermodynamically viable. The CO2 that "leaves" the cycle each turn during condensation is ALWAYS from an incoming malonyl-CoA because of this specific reason :) The resulting palmitate (the product after its hydrolysis from FAS I) therefore has C15 and C16 from the original ACETYL-CoA, the rest comes from these "temporarily carboxylated" building blocks, malonyl-CoAs :) Hope that made sense!
Anyways, I absolutely love these videos. I'm in the final stages of cramming for my very last exam for my PhD in biochemistry and these videos always give me an immense motivational boost... and I can listen to them anywhere, too! Good thing I have discovered this channel before it's too late. NinjaNerd, prof. Zach, you are a lifesaver :)
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تعبت وانا اقول اسطورة، توفير وقت وجهد، الطب صار سهل
We're learning this in BCH! Thank you so much for this! 😊
Thanks for the great video! Small notice: ATP is negatively regulating Isocitrate Dehydrogenase, not the Aconitase. You explained it correctly in part 1. Cheers.
At step 10: IMO the leaving CO2 should be the one from the Malonyl, the Acyl group does not have oxidized carbons to release as CO2.
@@hmone yea I was just about to comment this lol
@@hmone yeah. in the next step too. to retain the OG 4Cs, the CO2 should evolve from the new malonyl group on ACP
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Thank you so much! it would be extra excellent if u could show the Chemical structure of the reaction species of addition of old Malonyl chain with new Malonyl residue of ACP. But when I see that step 2nd time and draw the chemical structure by myself and thought of it ,,I just understood that!!! U r such a Nicer Human!!!
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