Pharmacology - OPIOIDS (MADE EASY)
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- เผยแพร่เมื่อ 22 พ.ค. 2024
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Opioids, sometimes called narcotics, are a group of drugs that act on the central nervous system to produce morphine-like effects such as pain relief and euphoria. This pharmacology lecture covers topics such as nociceptive pain pathway, role of glutamate, substance P, and calcitonin gene-related peptide (CGRP) in pain processing, endogenous opioids (enkephalins, endorphins, dynorphins), NMDA, AMPA, NK-1, CGRP receptors, opioid receptors (mu, delta, kappa) mechanism of action and side effects of narcotic drugs, development of opioid tolerance and addiction, partial mu-receptor opioid agonist and antagonist. Drugs mentioned include; Morphine, Fentanyl, Hydrocodone, Hydromorphone, Methadone, Meperidine, Oxycodone, Oxymorphone, Buprenorphine, and Naloxone.
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0:00 Nociceptive pain pathway
0:54 Neurotransmission of pain signal
2:57 Endogenous opioids & opioid receptors
4:32 Synthetic opioids
5:29 Side effects
7:19 Opioid addiction
8:50 Buprenorphine
10:02 Opioid antagonist - Naloxone
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Is it free?
Will it pay in Opiates?
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Nice timing, I have an exam on opioids in two days! Thanks!
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Does prolonged regular opioid use cause permanent changes in receptor function?
@@BigBodyBiggolo I too would like to know this!
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*WOW* ... you sir have got to be (so far & that i can recall) the only person who has ever got this FULLY CORRECT. I like how you noted that the effect opioids have on breathing really boils down to the sensor that detects how much co2 is present (& in doing so, essentially blocks-to an extent- the alert that warns a person when their co2 levels get too high..& so they would feel that urge to BREATHEEE, to avoid death)...one would be surprised just how few people actual are aware of this, they think opioids just make your lungs not want to move or something.
Also like how you mentioned the action Methadone has as an SNRI (tho i wouldve also liked to see you do the same for Bupe for it also has an interesting profile of agonism/antagonism). One last thing i was quite pleasantly surprised to hear you mention was the reason as to why Naloxone acts on the receptor as it does.. this is due to its HIGHER AFFINITY in contrast to other opioids!...again, this is unknown to most & it boggles their mind when you try explaining that to them especially when theyre not actually even aware that Naloxone (& naltrexone) are ALSO themselves OPIOIDS. Their mind is usually blown at that point & you then realize they just simply don't have the full in depth understanding as you may have.
Idk, sometimes i feel like i'm the one going crazy in such a seemingly ignorant-uneducated world, but alas i am humbled once i remind myself just how truly ignorant we all are myself included. Lol, so its all good!
Thank you much for this, refreshing!!
Thank you for your thoughtful comment
I thought he said methadone acts as an SSRI? Meaning it can cause serotonin syndrome.
Low dose bupe is being investigated for treatment resistant depression
Thank you sir, Very good explanation...
Thanks dude. Former opiate taker. Very informative.