As a patient with ankylosing spondylitis that of course is doing some pain medication research, I like to say thanks very easy to understand and straight to the point
Interesting! I'm here because I have had opiate use disorder. I was in a methadone clinic for 17 long years. I've been out for 2 years. I'm interested in learning about what's happening in our bodies when we take these opiates & what is going on during withdrawal. What leads to addiction. I battled & sonehow came out of a severe addiction. I'm so thankful for my second chance! I lost many years of my life & should be dead, but here I am. So I want to learn as much as possible about what i did to my brain & body. Thanks for sharing this info.
Thank you. I'm doing a diploma on addictions and community healthcare and I was confused AS FUCK about the difference between an opiate and opioid. This is the first video on it I found that makes sense to me.
Hi great job, I always enjoy your explanations. You only show buprenorphine as Kappa but it is a Partial mu agonist as well. (or mu agonist and kappa antagonist)
excellent overview. Is there any research on +ve use of opiates(oids) in psychiatry for motivation improvement and elevated mood in patients with long term treatment resistant depression and or dysthymia? KR RCL.
I would really like to know what exactly do they do to the immune system long term? so ive been reading around the internet about it and the mu receptor suppresses the immune system? so It can't clear pathogens they build up or something? I read opiates also cause histamine release in brain long term which will cause brain fog and problems concentrating. Iv been reading opiates also cause Angeogensis especially the endothelial cells. will this angeogeniss bread cancer tumer growth? because rhe other paper I read said opiates bind to tumer sites and stops the spread of tumers
Hi, Love this, may want to differentiate the term hyperpolarisation from hypopolarisation. It's not clear from what you said. Very helpful though, I'd go with hypO, means low. :-)
@Dr Matt & Dr Mike You mentioned Heroin was a natural opiate but isn’t Heroin a chemically altered form of morphine? Meaning it would be semi synthetic…
People get confused on bup because it rides with noloxone in Suboxone. Buprenorphine is a stronger agonist for the receptor than other agonists. It binds stronger than the others but it is also only a partial agonist and therefore not as potent as H or Fent.
〰️〰️🙏〰️〰️ Consistently Pray for forgiveness, guidance in a good (positive) direction, and for help against evil. Pray to be saved from hell (whatever that may be). Pray for your friends and your family too, it only takes a minute or so/less at a time to pray. Do it and your life will slowly get better, or maybe quickly. It probably just depends on you and the kind of person you are/have been. Don't wait until its too late and you have to suffer the consequences of built up bad karma from immoral acts/unrepented sins. Maybe together we can help make the world a better place by changing ourselves for the better, and changing things around us for the better. And addressing/thanking the CREATOR, LORD GOD at the beginning and end of your prayers would be a good idea 😊 Or just be my friend if you don't want to say the prayer 😄 I'm trying to help you get right with the LORD🙏 Amen. You should prostrate yourself if you don't want to do spoken prayer, or do both☺
Did u know that we dont have a full 100% pure agonist. Nope. All opioids activate the mu receptors to different degree A 100% activation produces Catatonic state,Even in minute doses
"if you change perception, you can change pain." how very medically and philosophically correct!
What you do for us is beyond amazing, so simple so clear and straight to the point. Can't thank you enough.
YOU HAVE A WELL EXECUTED AND ORGANIZED WAY OF EXPLAINING THINGS! LOVE YOUR VIDEOS!
YOU'RE SUCH AN AMAZING TEACHER :) Im so glad I found your channel!!!
Brilliant explanation, simple and clear. Thank you Dr Mike :)
You made it so simple to understand it modulates my perception of pain studying how opioids work
As a patient with ankylosing spondylitis that of course is doing some pain medication research, I like to say thanks very easy to understand and straight to the point
Thank you Dr. Mike!
You made it crystal clear with your amazing explanation, all the blessings❤️
Another awesome video. Thank you so much, you guys make this information easy to understand.
Thank you for making such a clear concise video on this!
A very through explanation, thank you for making thu video ! Great work Dr Mike
I am a visual learner, your teaching is saving me!
Thank you for an amazing video. I wish you were my teacher in med school. Much love Bro.
legit, for concepts I don't understand - I just look you up, and bam! you explain it so well. thank you!!
How you explain these concepts is a game changer to me, thank you❤
I just wanted to let you know that you’re life saver thank you for to the point concise yet detailed tutorials, love your pink shirt lol
You are SO GOOD! Thanks again for an easy to understand and awesome video!
Interesting! I'm here because I have had opiate use disorder. I was in a methadone clinic for 17 long years. I've been out for 2 years. I'm interested in learning about what's happening in our bodies when we take these opiates & what is going on during withdrawal. What leads to addiction. I battled & sonehow came out of a severe addiction. I'm so thankful for my second chance! I lost many years of my life & should be dead, but here I am. So I want to learn as much as possible about what i did to my brain & body.
Thanks for sharing this info.
Thanks a lot for your kindness and willingness to help other. ❤
Wow! This is simply a perfect explanation. Thank you!
love your explanations, clearly explained and understandable.👍🙏
Happiness is getting a notification for Dr Mike's classes
You're an absolute GEM, thank you!!!!
Great presentation. Refreshing!
excellent simple explanation! thank you!
Dr. Mike thank you for an amazing lesson!
Thank you. I'm doing a diploma on addictions and community healthcare and I was confused AS FUCK about the difference between an opiate and opioid. This is the first video on it I found that makes sense to me.
Thanks 😊
Hey wondering how many "addicts" are actually just chronic pain patients that doctors won't treat properly anymore for fear of dea
You should do a video explaining caffeine
Buprenorphine is a Mu recptor agonist and Kappa and Delta antagonist
Yup, idk why he said it’s a kappa agonist
@@69Tridentspartial agonist at the mu
1st viewer thnx for this wonderful lecture on cns pharm
Thank you very much. Great explanation. 👍
Hi great job, I always enjoy your explanations. You only show buprenorphine as Kappa but it is a Partial mu agonist as well. (or mu agonist and kappa antagonist)
A really useful video, can't thank you enough!
Thanks for perfect explanation! You are a magic man! Where do you learn all this things ? Do you have any good patophysiology books for recomendation?
takes no glances at notes, IQ 9000.. much respect
Excellent introduction
Thank you!
Can you please do more cardio lectures including eTG guidelines explaining why certain therapies are used?
Mom l
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That was extremely helpful. Ty
this helped me a lot! thank you!
Awesome. It was very helpful, thank u so muchh😊😊
Could you make a video about psychostimulants?
Love the energy
Best of the best....thank u
Buprenorphine is actually not an agonist, but an antagonist for the kappa receptor, and is a partial mu-receptor agonist
Thank you for the informations
Thank you dr mike❤
Thank you!
excellent overview. Is there any research on +ve use of opiates(oids) in psychiatry for motivation improvement and elevated mood in patients with long term treatment resistant depression and or dysthymia? KR RCL.
Thank you so much sir🙏, can i know the references
Excellent!
Simple and perfect
I love you.. you just saved me 5 hours of studying
love from South africa
I would really like to know what exactly do they do to the immune system long term? so ive been reading around the internet about it and the mu receptor suppresses the immune system? so It can't clear pathogens they build up or something? I read opiates also cause histamine release in brain long term which will cause brain fog and problems concentrating. Iv been reading opiates also cause Angeogensis especially the endothelial cells. will this angeogeniss bread cancer tumer growth? because rhe other paper I read said opiates bind to tumer sites and stops the spread of tumers
Hi, Love this, may want to differentiate the term hyperpolarisation from hypopolarisation. It's not clear from what you said. Very helpful though, I'd go with hypO, means low. :-)
Dr Mike can you make make Ur videos more longer and derailed. Pls 👉🏻👈🏻
You are the best
Oh yes thank you! That’s why the it’s a godsend and it’s right to treat ppl with opioids because they are efficient and effective! 👍❤️
🎉simple and perfect
Perfect 👌
Excellent
I LOVE OPIOIDS
Buprenorphin acts as an Antagonist on Kappa-rezeptors ,not as an Agonist.
Thank you. I'd remembered buprenorphine as a kappa antagonist, not an agonist, so that gave me pause. I looked it up, and yep, it's an antagonist.
This guy is insanely smart
So cool
Hydromorphone is the absolute worst for causing constipation!!
i want to learn about how the opiates affect the nerves
Thank you a looooooot
@@marylawson9524 no thank you
Hello!
So we aren’t gonna be synthesizing any heavy Opi’s? Oh, someone’s at the door
Tramadol?
Credit. 👍
Where does Vicodin come in on this list ??
@Dr Matt & Dr Mike You mentioned Heroin was a natural opiate but isn’t Heroin a chemically altered form of morphine? Meaning it would be semi synthetic…
Please i need you help with my school work i have troubles with my assignment. Please i need help thanks
i might not be able to help but i might be able to help. what's the assignment question?
I just popped a Percocet for anxiety and anger
As opposed to ADORAL
Slow down.
MISTAKE: BUPRENORPHINE ACTS AS ANTAGONIST
it's is an antagonist at delta and kapa receptors
and an agonist at mwue receptors
it's a partial agonist at u(mweu) receptor
People get confused on bup because it rides with noloxone in Suboxone. Buprenorphine is a stronger agonist for the receptor than other agonists. It binds stronger than the others but it is also only a partial agonist and therefore not as potent as H or Fent.
Sesame street. Color, motion?
Cool shirt, does it only come in womens Small?
4:45 What?? Brainstem is at least as much responsible for breathing than medulla.There is no breathing wihtout brainstem.
〰️〰️🙏〰️〰️
Consistently Pray for forgiveness, guidance in a good (positive) direction, and for help against evil. Pray to be saved from hell (whatever that may be). Pray for your friends and your family too, it only takes a minute or so/less at a time to pray. Do it and your life will slowly get better, or maybe quickly. It probably just depends on you and the kind of person you are/have been. Don't wait until its too late and you have to suffer the consequences of built up bad karma from immoral acts/unrepented sins. Maybe together we can help make the world a better place by changing ourselves for the better, and changing things around us for the better.
And addressing/thanking the CREATOR, LORD GOD at the beginning and end of your prayers would be a good idea 😊
Or just be my friend if you don't want to say the prayer 😄
I'm trying to help you get right with the LORD🙏
Amen.
You should prostrate yourself if you don't want to do spoken prayer, or do both☺
Did u know that we dont have a full 100% pure agonist. Nope.
All opioids activate the mu receptors to different degree
A 100% activation produces Catatonic state,Even in minute doses
Well I hope this info is more believable than FAKE VIROLOGY
Nature. Opium
Probably my worst video from Dr Mike…..I was completely bored with this topic
Chronic pain patients MUST HAVE TO FUNCTION TO LIVE