Pharmacology - NSAIDs & PROSTAGLANDIN ANALOGS (MADE EASY)
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- เผยแพร่เมื่อ 22 พ.ค. 2024
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NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are painkillers commonly used to treat pain, fever, and inflammation. Prostaglandin analogs are simply mimickers of endogenous prostaglandins, which are hormone-like substances involved in numerous body functions including the dilation and constriction of blood vessels, control of blood pressure, modulation of inflammation, and the contraction and relaxation of smooth muscle. This pharmacology lecture covers topics such as the role of cyclooxygenases (COX-1 & COX-2) in inflammation, thromboxane, prostaglandins; mechanism of action, therapeutic uses and side effects of NSAIDs and various prostaglandin analogs. Drugs mentioned include; Selective COX-1 inhibitors; Ketorolac, Flurbiprofen, Ketoprofen, Indomethacin, low-dose Aspirin; Non-selective COX inhibitors; Naproxen, Ibuprofen, Piroxicam, Diflunisal; Selective COX-2 inhibitors; Meloxicam, Diclofenac, Celecoxib, Etodolac; Prostaglandin E1 analogs; Alprostadil, Lubiprostone, Misoprostol; Prostaglandin F2α analogs; Bimatoprost, Latanoprost, Travoprost; Prostacyclin analogs; Iloprost, and Treprostinil.
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0:00 Arachidonic acid cascade
1:35 Nonsteroidal anti-inflammatory drugs (NSAIDs)
5:57 Prostaglandin analogs
10:18 Prostacyclin analogs
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When he said that COX 1 inhibition had "highest risk" he should have added "higher GI risk" but less cardiovascular risk. COX 2 inhibition has higher cardiac risk.
Haiwawo
@Tichaona tissangane kuinibhokisi
Thank you sir
your 11 mins lecture is wayy far better then my faculty"s 1 hr lecture
respect from india
Our teachers explain this in 3 hours🤓
Thank you so much for this!!! Your videos really help me understand pharmacology! Literally right on time for exams next week! God bless you!
Another fantastic lesson, wow...thank you! I can't imagine how long it takes you to find/make all those illustrations and sync them with your narration. This is masterful teaching in my opinion.
Your videos are best. I have been watching your videos for last one month and i have found them so helpful in better understanding of my pharmacology concepts. Your easy explanation and to the point explanation makes it fun to watch and learn. Hope to see more awesome videos in the future. :)
Starting pharmacology this year and this was so informative!
Thank you! Your videos are great, waiting for other topics in pharmacology 👍
You are amazing! Thank you so much! Please make some more!
This explanation was perfect, using images made it more effective and easy to understand thank you
One of the best things you do is start off with the normal pathways and mechanisms of the body these drugs affect. It really helps understanding to start there and not just 'memorise fact A is A because it's A". It makes SENSE this way.
thank you very much for all the well done lectures. it is no easy task and u did a great job. please continue the good work for the greater good. Nobody knows everything and no one can be perfect. your lecture has made work easier for a whole lot of us. thank you again.
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Ur classes are different from others.same every time and very clear.learning is easy with you.
Please make a video on the Chemo chapter... and thank you for these amazing videos. Keep 'em coming! ;)
I wait for your videos it makes the stuff oversimplified ... always keep it 💖💖💖
Aw man this video is awesome. THANKS YOU SO MUCH!
thank you so much. It was indeed a great effort to make students understand the basics of PG. It was a beautiful video. Well done !
Yes true
Extremely perfect ,I love your lecture...
I love your channel. I love your accent. And now I like Pharmacology❤️❤️❤️
Hoping to study biomed research next year and this was fun to watch!
Very helpful, very well illustrated, very well explained..
God bless u..
Ketorolak, Flurbiprofen, Ketoprofen, Indomethacin, Diclofenac and Etodolac are non-selective COX inhibitors.
Exactly
Yep
Best channel for pharmacology 👍
I'm just a normal person but i like to study I'm so glad I found this channel!!!
Na, u ain’t normal
I don't like the notion of normal, we're all very different in great ways and we should embrace the yearning for knowledge. Always good to learn new things.
@@RunCmp lmao
Aw I hope you’re having a great life fellow human, science is awesome
I'm so lucky 😍 my exam on Sunday & on my schedule I have to study this lecture today !!! Thank you so much ❤
Did u pass?
@@23k31 of course I graduated med school too 💃🏻
@@samnoah6019 congratsss
Iam glad I found this channel
Thank you.. I needed a brief review since it's been awhile since taking pharmacology
Thank you so much for the video sir .
I would like to request you to make some more videos on the remaining topics in autacoids like Migraine,Gout and of the other units as well.
your videos are always the best
Thank you
This is amazing, I'm glad to have found this channel. Can you please make a video on drugs used in parkinsonism and other movement disorders pleeaase
Whenever I get a chance I'll refer your channel to all my junior students.. Please upload videos of on every topic of second year pharamacology.. Please I beg you sir... Your videos made me concepts very very easy.. Please sir please do more & more videos
Finally I found the perfect channel for pharmacology 👍
....from India ☺️
Me too
Thanks a lot Sir!!.. Great explanation..!!!
i wished this video came out earlier before my pharmacology exam :'(
Where are u studying medicine? (from which place)
Excellent Mode of Teaching
Yessss I was waiting for a new video ❤️Thank you so much.
Can you also please make a video about CNS drugs or anti-microbials? Those topics are so huge and I find them very tough. It would be great if you made a video about that.
iFenom_z same but I find these two topics kinda tough
I'm just about to take those class next semester. CNS + Antibiotics!
Yeah , especially the antimicrobials... we've recently finished that chapter and it's giving me grey hairs.
Really love this chennal ❤️❤️❤️
WOW! nicely described
What a fantastic explaination
Super helpful!
Videos aren't made quickly enough... This channel is my No.1 resource for my Pharm course, and whether or not I ace a topic depends on whether or not videos on that topic were available. Sad, but true. Plz, plz make more videos... in the mean time, I'll be finding other (less thorough) resources to study from, which inevitably means 3-4 other resources besides my lecture notes, at the LEAST.
Excelent video, thank you!
Wonderful thank you so much
Love u bro.. u have made my life easy.. plz upload videos on serotonin agonist and antagonist
Excellent Presentation
Always helpful video 👌👍
you are incredible. Thumbs up
in some articles, COX-1 and not COX-2 drives PGI secretion, however, in some books, COX-1 and COX-2 both drive the secretion of PGI-2, that's why Selective COX-2 NSAIDs have been re-instated clinically.
Very good video for test. Thank you
Thank you teacher
Thanks a lot you are the best
I'm so grateful👏👏thankyou👌
Thanks for explaining the differences between various NSAID medicines.
thank you for your video!
Can you please make a video on anti gout drugs? These are so good, thanks!!!!
Thanks. Any chance your slides are available for download somwhere?
That was great
I memorized my lecture easily after watching your explanation
Can you please make one for corticoids?
you make things awesome
Thank you sir.... Thnks for a brilliant lecture ... Our requests for u
Plzzzz Sir upload cns drugs video....
"Relative" COX selectivity data presented in this video was obtained from the article published in European Heart Journal (March 2016): academic.oup.com/eurheartj/article/37/13/1015/2398407
Also, although I try to obtain information from reputable journals and medical textbooks keep in mind that it may be outdated at the time you view this video. Furthermore, this is not a therapeutics lecture and it is not meant to provide any treatment advise. Please read the disclaimer for the channel.
Thankful for your efforts.. 😉🙂
thanks for the clarification
We cant see all screen. Half screen seen
You simply the Best 🔥
Hi man,great video. I just subscribe. I'm wondering what software you use for the white board and the video editing software you use? Thanks
Can you pls reference the table @3.08 as other texts say all that mentioned in selective cox 1 inhibitors are actually non selective?
thanks for this informative video
Yup PERFECTION sir ☝️💪
Thanks really helpful.✌
Indomethacin, sulindac,
meclofenamate, and ibuprofen nonselectively inhibit both COX-1
and COX-2. Please correct that mistake. Refference: Basic & Clinical Pharmacology [Katzung, Trevor] 13th Edition (2015)
Adamsın
Peki ya COX-3?
Indeed
I second👊
What told by sir in video is correct
Ref the following web
www.eurekaselect.com/72639/article
Thank you for the amazing videos! Could you make one about anti-epileptic drugs?
th-cam.com/video/ATYmaTmh9RE/w-d-xo.html
Awesome video
good job sir , thanks alot
Great Video. Thanks for simplifying things for me. Now lets hope that I will pass my exam on 7th December 2021
did u pass it
@@alessandrononinosacher Gave exam last Tuesday. Result will come in first week of January. I am sure I will pass.
Ketorolac and indomethacin are non-selective not only work on cox-1 as mentioned in the video
I use Ibuprofen when I have a non bareable period cramps. It does reduce the pain on abdomen and down there area
Nice video sir!
Sir where can I buy I need this prostaglandin E2 injection or the tablet
Diklofenac is not a Cox-2 inhibitor. Can you please give me your source on that one?
thanks for the video
Sir please add antimicrobials topic also
Can I suggest that you should upload a video about vasoactive peptides?
Can you do upper GI meds soon? H2RA, PPIs, drugs for N/V?
Jazak Allahu khayran❤
you`re the best .
please upload video of antipsychotic drugs
nice video keep it up!!!
May Allah give u reward
Thanku for this video...
The list of medications that are selective and non-selective Cox inhibitors is not correct. Celecoxib is the only true Cox-2 inhibitor on the market in the US.
Thanks heaps 🎉
Great 💯
Can you elaborate renal effects of nsaids?
good work
Thank you ❤️
Well explained
Can you please make a video about immunomodulating drugs (only the cytotoxic drugs)
I really need it in 10 days
Please add this video to the playlist ..
Neither diclofenac, indomethacin nor keterolac are selective.
These three are for sure non selective
Please check your sources for your lectures, there is a big mistake in classification of NSAIDs according to COX selectivity, as you classified diclofenac, meloxicam, and etodolac as selective COX-2 ?!!!
Generally your videos informatics.
so thanks for your attempt ❤️❤️
بژي كورد 👌❤️
It's right na! They do belong to selective cox-2 inhibitors...
i know where you getting this, these are preferentially cox 2 inhibitors which mean they have a little cox 1 inhibition too. but due to maximum activity on cox 2 he just simply classified them into selective cox 2 inhibitors. so that's not make any difference...
There is no selective cox1 inhibiter, only preferential activity on cox1. (Inhibition is more on cox1 but not exclusive)
Thank you sir