Funny enough, I had a three month period where I was drinking pepto every other day (not exactly measured, about the equivalent of a swig) due to free coffee at work. I lost a noticeable amount of body fat. After I switched jobs, I gained weight without changing diet/exercise and removing daily coffee/tea consumption. Unfortunately, I had two factors impacting this timeline (coffee/tea and pepto) so I can't say it's due to one or the other since all other variables in my day to day were unchanged. This paper is rather interesting to me due this experience.
The active ingredient in Pepto Bismol is bismuth. I've read that blueberries and some other berries also contain it, and I've seen blueberries mentioned as a folk treatment for diarrhea, which is one of the uses of Pepto Bismol.
@@1truemooseBlueberries also contain anthocyanins the purple and blue hue pigment found in many other food (like dark opal basil, sweet onions, purple cabbage) it has been researched to be anti diabetic and may have potential to be anti obesity as well. In some studies it has shown to Ameliorate Mets in a does dependant manner. blueberries also raise NK cells which you need to kill off senescent cells and we are now doing research to reprogram these cells to specifically target sedentary cells. Blueberries consumption was also related to lowering blood pressure and unstiffen blood vessels in one study.
Nick, I'm a nutrition student from Libya, and let me tell you, if you were to make this claim here, it'd shake the grounds of the entire healthcare system as a whole. They still think eating whole eggs will raise bad cholesterol and that you should only eat egg whites. I'm planning a massive coup against these monochromatic thinking patterns, and I'm more than blessed for having stumbled upon your research. I came here from watching your podcast with Thomas Delaur. You're absolutely awesome and based, man! Keep up the good work Man!
I paid to read this paper via nature. It was absolutely amazing. I have never read a study that gave so much . I read the first few pages and thought wow- what results and they kept on coming. As a 1st year undergraduate nutrition student this was amazing for me. Thankyou for highlighting this paper Nick 🙌
Does the paper shares how much pepto to take or at which times? I am willing to start taking pepto for a month just to try it. I am thinking at night, before bed... perhaps after my last meal too. But I don´t want to pay fo a paper and find out it does not have that info..
learn what they teach and then learn outside the box. I do holistic nutrition and when my. husband went to a medical nutritionist her info was so bad I almost fainted. About 40 years out of date
Uh WOW! (oh and by the way, I was watching your video very carefully and I have to say with your careful editing [I can see the subtle cuts], and even though your information does come very quickly, there is not a single wasted word. Amazing efficiency in information sharing. Not a single um or ah; no wasted words or mindless repetition. Astoundingly efficient and straight forward. Your careful production and scripting is so impressive and appreciated)
Yes… no fillers … just enough background, science and practical application to get the job done. Hopefully, the channel won’t eventually go down the typical rabbit hole.
We need intensive science focus (10,000% increase) on uncovering information like this and totally changing what we allow governments and corporations to do to people bodies.
Interesting. Many years ago, I once got into a argument with some health doctor about hydrogen sulfide as being a cause of chronic fatigue system (I was arguing that it was. He wasn't having any part of it). So, all these years later, hydrogen sulfide again pops up. I'm going to say there is some connection with exercise. A quick search shows: exercise increases GLP-1 levels in healthy and obese individuals. I've exercised regularly for years. It's also been many years since I have told anyone I had chronic fatigue. Anecdotal, I know. It might be that exercise isn't increasing GLP-1, but that it is improving hydrogen sulfide metabolism, which in turn fixes other problems.
Note that "Western" diets pre-1960 was vastly different than the same diets today. Most people drank water, soda or other sugar sweetened drinks were a fairly rare treat... as was going out to a fast food place. Carb heavy meals were eaten, but there was little of the "instant" or "quick" carb meals. Packaged meals were the old aluminim foil TV dinners... and were rarely eaten. And while trans-fat margarines and seed oils were fairly common, corn oil was the main one sold, soybean and cotton seed oils still had problems with people having allergies to them, and rapeseed oil was used for lubricant... and you need to wash your hands THOROUGHLY... they had not developed the "safer" canola strains of rapeseed.
Incredible video!! Awesome facts, brilliant delivery, tad bit of humor, tons of enthusiasm!! Bravo, Nick! I hope you can do this forever!! I applaud you!! Thank you! Very cool info. Too many humans are sick and dying from foods we eat (type 2 diabetes, etc..)
What I don't like about suggesting that fiber could be a cure is that same short chain fatty acid is produced during intermittent fasting, a superior way to deal with metabolic syndrome. Also, carbs got them into this mess. I'm not sure advocating for more carbs is the best answer that can be found, especially since I just suggested a better one. The entire medical industry's efforts towards GLP-1 are so that people can continue to eat carbs and sugar while having the effects of intermittent fasting. It seems like a lot of trouble just to keep being addicted to carbohydrates. Imagine if we put this much effort into letting people continue to smoke cigarettes? We'd think everybody to be mad. Well, it's just like that but with carbs. It's madness. Stop combining highly refined carbs and vegetable oils together. It's not a difficult concept to follow but it gets rid of people's favorite addictions like pizza and dessert.
Baseless rant. Fiber is not a simple carbohydrate. Various fibers have been shown to be healthy in large number of studies. Low fiber consumption is linked to cancer.
I totally agree that intermittent fasting, quality animal fats and protein is the way to go. Also, for natural GLP-1 inducing supplements- unsmoked Yerba mate tea for your caffeine, the sweetener Allulose and the supplement berberine with meals. Your welcome.
The people who get into weight problems are already having a very hard time functioning. Nothing wrong with a very very cheap low risk pill-much less risk than the new “wt loss” injections. We can encourage them to eat better one step at a time, while taking that simple pill as an aide. Emotional pat issues & current super stressful lives, & even grieving for lost family or friends can trigger intense cravings for carbs-to “naturally” boost feel good brain chemicals. Helping hurting people with a simple low risk, cheap pill is the right thing to do. If you know someone at risk for health problems because of high wt, you can volunteer to walk with them, or help them with a gentle resistance or low level wt lifting. You concern is commendable, & I am sure you could be a help to many people. God bless
I was on keto and lost a 30 pounds. Switching to carnivore 10 months ago, I have lost an extra 25 pounds, while getting more lean mass. Never felt better and all metrics are perfect. High LDL is the only concern my doctor has (560), but we all know what is going on there…
I would do a CAC. With a CAC in hand (especially a 0 score). It "relieves" your doctor from carrying you as a non-compliant patient. If he gets too many of those, the insurance company DISCOUNTS his ENTIRE check every month. Our PCP was ready to ask my wife and I to leave his practice to help him out. Wow. We got the CACs and we are compliant with NOT taking statins...
@@michaelchristensen2786 Why? If you had a ZERO CAC would you still do that? Part of the argument is that the PROOF just a high LDL is bad. My brothers was LOW when he had his heart attack. Ask yourself why insurance companies pay for the drugs. Punish doctors who don't push them. And WILL NOT pay for the CAC which is required for all NASA Astronauts and Fighter Pilots. Because of the value of it's risk assessment...
If the g.i. System is in an inflammatory state food particles don’t get broken down properly and bits of almost every food you eat can migrate to places they shouldn’t be. Your immune system will see the pieces as invaders and attack them and you will test positive for many food allergies. Once the inflammation has calmed down, the gut wall healed, the microbiome repopulated then you can start reintroducing foods that may have come up positive on a test but you don’t remember having problems with them in the past. It’s a slow and gradual process to heal. If done deliberately while paying close attention you can probably eventually eat most things you like that are real food in small portions for short periods of time. Being omnivorous can be both useful and enjoyable. It just takes a bit of work to get there.
Why add back food that poisons you? Plants broke your system. Why would you want to add them back. Nobody actually likes them until you add fat or sugar to them. Once you heal your body trust you tastebuds except with sugar. That will always be an addiction to avoid.
Palmitate dysregulates GLP-1. H2S is an epigenetic signalling molecule that regulates demethylation. Switching genes off. It's absolutely essential. If it's turning off GLP-1 in the gastrointestinal tract, it just means you are deficient in NO nitrogen oxide, which counter balances h2s demethylation, or you are deficient in fumarate which quanches excessive h2s reactions, or excessive palmitate exposure. Deficiency in NO has been implicated in the current surge in gastrointestinal cancers in young people as of late.
Pepto blocks a lot of things. If you are eating garbage, it is probably just blocking some of the biproducts. What you SHOULD eat, boils down to genetics. A huge problem arises when we generalize . This is true of the food you eat AND your microbiome. We simply are not all designed the same , and there is no universal chart that is going to work for everyone. For example, I have recently discovered that a carnivore diet is ideal for me at this phase in my development...at least for now. I am not addicted to carbs, so this is actually rather easy for me. At my peak, I was almost a vegetarian . That worked well for me for YEARS, until it didn't. I was an ultra runner. I ate whatever I wanted( I love veggies like peppers, pumpkins , tomatoes and beans. I like meat, but it's super boring compared to eating a wide variety of veggies.). I never craved sugar or processed food. I preferred to garden and grow my own veggies. I like the idea of producing my own food, but I'm not killing any cows. I am getting meat from local farmers right now. Aside from hiking and running, growing my own veggies was my favorite hobby. But I experienced a "perfect storm" about 10 years ago that threw me into a downward spiral. Long story short, they discovered two huge parathyroid adenomas . I had developed an extreme case of hypercalcemia. My body was sucking calcium out of my bones. My blood calcium was so high I had to be hospitalized. They never would have found it had I not broken my wrist. But was it my diet or lifestyle? Nope. I was living on homemade veggie soup, salad (my favorite food) and lean meat and fish. I was running marathons every weekend and ultras once a month. I felt great for years. However, I have a genetic defect. I have thalassemia trait. This is NOT a disease and it is not that uncommon. It isn't thalassemia. It's just Thal TRAIT. This means that my blood cells don't carry as much oxygen or iron. Technically, this is no biggie. But I was pushing myself to extremes. This is WHY I ate very little meat. A low iron diet was ideal for my genetic make up. I have to be careful about iron overload. But when my body was breaking down, my life was falling apart and I had acquired chronic fatigue, I was still eating mostly carbs...good carbs, .but still carbs. And so, I started getting food sensitivities. Even iceberg lettuce caused me to bloat up like a balloon. My skin was peeling off. I gained weight quickly, even though I had gone down to 1 small meal a day. Ultimately, I decided to do the carnivore diet and it has worked wonders. However, it would be stupid for me to stay on it forever without "detoxing" from iron from time to time. My kidneys would start failing. That's just a fact. The iron overload would be just as bad or worse as the chronic inflammation caused by the phytonutrients in vegetables. So, for now, I am doing a high fat , low as possible iron diet on meat to detox, but it can't be a permanent lifestyle. Lean proteins like chicken, white meat turkey, cod, mackerel, and salmon are LOWER in iron than red meat . But they all have iron. And iron builds up in people with my genetic make up. Also, those leaner meats contain tons of protein, which has its own problems when you are going near 0 carb. I hope to eventually be able to properly process some home grown vegetables again without inflammation. Right now, the carnivore diet makes me feel good, but I know it isn't going to be a permanent solution. Iron overload can be a factor in Alzheimer, and that's what I'm trying to avoid. Everyone is different. If anyone out there has read this far, I have a question. I am trying to do some research on a bacteria called Streptomyces pilosus, a bacterium species from the genus of Streptomyces which has been isolated from soil in Rome in Italy . I specifically want to know how to find it, perhaps in biofertilizer or something, or maybe fish tank friendly bacteria products? But it isn't listed on any products I can find. I was hoping to grow some vegetables in soil enriched with this. I think big pharma is hogging all the data, because they are working on some product this bacteria makes that may delay the onset of Alzheimer's disease. I mean, Streptomyces is everywhere. It's in good soil. But this specific strain creates a specific antibiotic for a specific kind of Alzheimer's caused by the The apolipoprotein E (APOE) gene. I have found some evidence that this gene is often found in people with Mediterranean blood (I'm half Italian) that have thal trait... a trait no doctor anywhere has a clue about and has no advice for other than "don't eat too much meat and never take iron supplements or you could die…but other than that, it's nothing to worry about". Side note: (Weird thought) Isn't it odd that this bacteria in the soil of Rome can cure people specifically from the region that happens to have the highest population of people with a specific blood abnormality? It almost makes me wonder if we all thrive best near the soil of our actual ancestors, because of specific bacterial strains in that soil. But see what I just did? I generalized. The whole point of my post was to point out that generalizations are never accurate.
I enjoyed your post and I agree with the wisdom of not generalizing. We are all different. I do like the idea that coming in contact with our ancient homelands has benefits for our health.
@@CarnivoreStork I can't answer that decisively, but I can tell you that eating one meal a day has done wonders for my energy, Fasting off all raw vegetables and carbs for one week actually improved my eyesight significantly (I don't even need my reading glasses while teaching right now, which is totally amazing) and my mood. I am totally guessing here, but I "feel" like this could have something to do with microscopic parasites. If we change things up, it just stands to reason that we would starve off any overgrowth happening from habitual eating. It is for this reason that I don't think carno should be a permanent thing.
I make a whey powder shake with yoghurt and inulin as well as psylium husk & coacao powder, maca, lecithin. Lecithin is a great source of choline the deficiency of which is main cause of fatty liver.
People who have hydrogen sulfide SIBO (or SIBO type III) use Pepto bismol as part of their treatment plan, so I'm not surprised by this news. What is surprising is that it helps others not diagnosed with SIBO. Very interesting development that might suggest SIBO type III is related to the more common condition of metabolic syndrome.
I thought this exact point was interesting as well. I have struggled with hydrogen and methane SIBO for decades and I do not have metabolic syndrome and I’ve always been skinny and fit. SIBO is extraordinarily complicated and even more complicated to treat for good. I do think having SIBO and being very health and diet aware has helped me stay lean so that’s the only good thing about SIBO.
Interesting!My diet is 'Carnivorish' (70%+ calories from animal products) but eat lots of onions (inulin rich) and use 5 to 10 gms daily of ground chia seeds (insoluble fiber rich to increase SFA's in lower gut and successfully replace need for electrolyte supplements). Much happier with onions and chia than with 100% carnivore diet from the perspective of satiety,mental and physical performance and consistent bowel movements.This study reinforces decision.😊
When eating an onion, you typically eat a slice, which is minimal carbs, maybe 1-2 grams, at most, as one medium-sized onion has 10.3 grams of carbs (4.7 in sugars). So carbs from onion intake are negligible, unless you're eating a whole onion daily. I eat a slice on my eggs in the am, and it doesn't affect my blood sugar at all. I'm also high-fat carnivore, and the only "veg" I eat is the slice of onion on my eggs every am. People always trying to be contrarian and difficult. Get a life, lol.
A beautifully put together, informative video, backed by by scientific fact and actual research, and broken down in a simple way for people to understand. Thank you also for using sane and respectful video headings that is why I "clicked"... Brilliant work!🥇💫
Interesting. I’m stage 4 of two types of Lipedema. Lipedema affects mostly women (99% of its victims), causing uncontrolled painful fat production. Where normal fat can release its energy, fat cells affected by this disease cannot. Diet and exercise have little effect on reduction. As an example, I went on 1000 calorie or less per day for two years and GAINED ten pounds. While a keto or carnivore diet has helped some, anecdotally, Ozempic has been working for most Lipedema patients who’ve tried it. We are working to get the manufacturer-or any scientific body-to officially test it on Lipedema. It would be interesting to test this. Thank you.
I’ve heard astonishing things from carni in women with that It takes a longgggggg time, but the dysfunction *turns off* and then the excess leaves! I’m talking these women have or are doing this YEARS. 1-2 before the buildup noticeably is leaving. Pain seems to improve within 4-6 mos tho. That must be huge. I’ve had something that caused stinging shooting pain for a longgg time and it was so hard.
I don't know much about this but I do have it, at least 1 genetic marker. It is a very frustrating! My PA has Lipedema and is pretty helpful when I can afford to go!
@@PurpleLady9555 I have Lipedema in my arms and legs as well. Years ago, I read about fecal transplant from a non “obese” person changing the micro biome. Would love to know if it’s ever been tried on a person with lipedema.
This is an interesting video and study. You might want to warn your viewers, though, that taking Pepto-Bismol for an extended period of time can lead to bismuth toxicity.
Do you know how much can cause that in terms of daily amounts? ChatGPT told me this: Bismuth Toxicity: Symptoms: Long-term use can cause bismuth encephalopathy, which affects the brain and nervous system. Symptoms include confusion, difficulty speaking, memory problems, and in severe cases, seizures or coma. Toxic dose: Chronic exposure to bismuth can lead to toxicity, particularly if more than 2 grams per day is consumed over a long period.
The essential oils in caraway seeds have an antimicrobial effect on bad gut bacteria while not affecting good bacteria. Potatoes and rye berries have prebiotics to feed a diverse range of gut bacteria. So i mean, use prebiotics to grow microbes and targeted antimicrobials to suppress the growth of undesirable gut bacteria.
I am guessing that a good time to use Pepto is before bedtime. So as to fight insulin resistance as your blood sugar rises when you sleep. Please correct me.
The paper was done in mice, and there are correlative findings in humans (metabolically unhealthy ones) which is interesting! But I wouldn't call that causative. In the paper with mice sure, but I worry your message is implying causality among every species. Great video though! Your editing and presentation skills are a level up since the new year!
Thanks for your thoughts. It’s causative in mice with correlation data in humans suggesting the same mechanism could apply. But proving unequivocally causation in humans can be difficult. I listened back and am comfortable with my messaging but I hear you. Thanks. And thanks for the compliment on production value… yes I got new toys 🧸
I have heard some pushback on AG1. Something about heavy metals. I don’t know who to listen to anymore. People on keto, some on carnivore, intermittent fasting, potato diet, sardine fasting and a plethora of other iterations on how/what to eat. I no longer know what to eat or what’s safe to eat.
Just eat unprocessed food and avoid any extremes. These carnivores are worse than vegans these days, so much so I'm wondering if it's propaganda by meat industry. But there is one thing all of these diets people glorify these days have in common: no processed food.
Also, just the fact that you are paying attention and listening to all these influencers or even competing advice will still point you in the right direction….. which is being mindful of your body. Whether you are eating sardines or vegetables of grass fed beef, because of your interest you are probably not smashing down potato chips and full sugar sodas etc every day.
Just eat natural foods. If you have access to a garden, even better. Then learn as you go along. I started out using the Blood group type diet. It made sense when I came across it since it explained why I had issues with meat, diary and oranges. So I cut them out for many years to clear health issues i had. Then I re-introduced them minimally to my diet.
I wonder which components of the western diet specifically are resulting in the increase in desulfovibrio? There's also some interesting research connections between leptin and gut microbial composition, so maybe there's a way to tie it all together. Could it be an indirect connection, where an obesogenic diet results in leptin resistance, which then negatively alters the gut microbiota? I'm glad you presented this info so that I can explore these questions further.
Well as the saying goes don't shop the centre aisles of the grocery stores because it's all killing you. Shop only the outside areas with fresh produce/meats etc! ONE exception is some stores have bread in the outside area*** walk on by and leave it there, all grains, flour/oats etc, are now toxic chemical dumps thanks to modern farming and will damage your gut bugs.
Honestly. Processed foods are full of so many things. For example, Ice Cream uses trehalose... Since they started it. C. Diff. infections are on the rise. Especially in the older populations. So, our gut microbiome is incredibly complex. After going carnivore, I stopped getting Sunburn "really easily". I believe it's the removal of the seed oils. Which don't like the sun. But it could be gut bacteria changed. Or my skin microbiome changed... It's complicated stuff... Complex Systems have Emergent Behaviors.
@@jaro6985 Not sure about glucose since body makes it's own glucose, xylitol and a few other sugars, but perhaps you are right about fructose and ethanol being key in increasing desulfovibrio. Certainly no sugars in the beef only diet and we seem to fix any metabolic problem with it. That seems to increase the gut biome diversity, not decrease it, as people have been showing their personal biome studies on social media. Very counter-intuitive, but it may be logical if we think about the reduced inflammation of such diets. With the body no longer fighting itself, the blood cells living longer and not being killed by the liver as the blood is purified, it's possible that the gut also benefits. Also perhaps bone and cartilage and organ meats may improve that biome diversity in a way that plants just cannot. Plus a person on beef only is probably also not touching toothpaste, cigarettes, alcohol, and certainly no plants or fruits with pesticides or processed foods and whatever is inside the products they use to make plant-based stuff or clean the containers they ship that stuff in. Sure would be interesting if they were to use beef-only as the control group in all the tests.
"which components of the western diet specifically are resulting in the increase in desulfovibrio?" - high fat diets, according to a 2024 study from the National Academy of Sciences.
Your mention of asparagus as being a source of inulin reminds me of what I read about models who must stay so thin. They eat asparagus and drink asparagus tea to get rid of excess water and bloating.
Point of inquiry: Instead of consuming fiber to produce SCFAs could you just eat foods containing SCFA for the same results such as cheese, butter, ghee, and cow's milk?
I would say yes, the science proves this and many people do not tolerate plant fiber these days. Grass fed dairy is many times more nutritious in everything (especially SCFAs) than grain fed, so that is a notable point.
Yes those with a salicylate/ aspirin sensitivity or allergy would not respond well to Pepto... This is interesting as sulphur helps with the detoxification of salicylate...
Thank you for this. It probably answers the question of why people who primarily get their calories from inulin tend to lose weight and those who primarily get their calories from starch tend to gain weight. I have inulin powder already, so I was able to figure out that 1 tsp of my powder weighs 5g.
Not true. If you research starch as in the book “Starch Solution”, combining starch and fats, then yes. You can live on potatoes and lose weight, get off insulin, statins etc
WOW NICK... You just dropped a bomb brother. My 5 year old daughter has metabolic syndrome amd many times we are im awe that she doesn't seem to register a "full" signal. Will definitely try!!!! Thank you as always brother.
Let's cut to the chase Doc, how much Pepto should we all be consuming? (yes, I said it, but know you're all thinking the same thing) BTW, I don't eat McDonalds, following a keto/carnivore plan. But have had a lifelong struggle with obesity.
@@furbytomo2562 Yes, I have asked the same question, and for how long can you consume it at the recommended dosage? The UK NHS Website advice (not a reliable source of info IMO) says no more than two days.
Wow! Wow! Wow! Wow! I can't wait for more on this topic! It is exciting that studies like this one are enlightening us about (potentially) how we got so sick and fat and (potentially) how we might reverse it without meds!!! This one hits home for me and nearly made me tear up! Thank you, Nick! Keep up the good work, please!💜
@@nicknorwitzPhD Is there any research on becoming GLP1 resistant from taking GLP1 meds? I wonder if that is why the does has to increase to keep the same effect--reminds me of insulin resistance??? If so, how do we find a balance?
Another question, will the mitochondria heal or regenerate naturally with the reduction of the hydrogen sulfate or are things we need to do to restore their function?
Good stuff! I love the taste of pepto, I could drink it as a desert. I swear I have that same bed frame, it was built by my grandfather, common design back in the day :).
If a diet results in less gas and in particular unpleasant smelling sulphur containing gas, does this mean that you are on the right path.......seams an obvious answer to me.
Inulin is the polysaccharide that gives you gas in beans and sunchokes. I'd wager the bacteria that breaks down the inulin is overpowering the HS producing bacteria by having a food source, plays a role.
No gas on raw beef only as far as I can tell. Heck, I don't even use the toilet but a couple times a week. The meat just seems to dissolve. Guess I found the right one? What 'bout you?
@@jd01665 they're speaking to HS producing bacteria. So the question is does the bacteria exist on a carnivore diet, and if so is it more or less than a diet with inulin. Doesn't sound like this study addresses this, so can't really say.
@@Unsensitive Thank you. Yes, it seems to not be addressed as to whether beef only is a good solution and why. Certainly telling people Pepto is a solution is crazy because they say not to consume it long term since it lowers your stomach acid levels and that can affect your risk of heart disease because you will have less nitrogen oxide in your blood and risk to have more clotting.
@@JessieJussMessy Only a fool believes that meat doesn’t dissolve in the stomach. How do we know? Two ways. One is you can put stomach acid in a container and test it. Second is if you do a quick search on TH-cam you will find people that have colon cancer from plants and they now have bags instead of a colon and they say that the bags are empty when they eat meat.
Hi Nick, as always a very informative video 👍 What daily dosage of Pepto Bismol would be required in order to secure the benefits you cite? Also, for how many days can you safely take PB at your recommended dosage? The UK NHS website (much of the advice on which is very suspect) suggests that you should not take for more than two days...what do you say? Thanks in advance, Anthony
Ways to Use Chicory Root There are numerous ways to use chicory root. These include: Using it as a powder as a coffee substitute Using the powder as an addition to regular coffee Blending the powder with other spices to make a tea Adding the powder to smoothies or oatmeal
Downside to making liquids with it is you are missing most of the inulin fiber. I would never eat oatmeal but that was the only one you mentioned that would get you all its healthy fiber.
Marvelous information well presented. About how much Pepto Bismol should I be taking daily? I've been keto, with intermittent fasting usually 16:8 for a long time.
Nick, a certain Professor Rachel Batterham did a study and research into satiation hormones. She found that a breakfast of 50g whey each morning raised GLP-1 & PPY levels enough to stop the patients from feeling hungry, after a eating anormal sized meal. They lost weight of course, and this meant the NHS could save billions from performing gastric-bypass surgeries in the long run. So, protein vs meds, and food wins.
Nick, you are smart, curious and amazingly focused on the science of a healthy diet. It would be wonderful if you could work with RFK Jr. on improving the health of our nation!❤
I hate inulin because it makes me so gassy. I'm a thin guy so not worried about obesity, but can you comment on whether the gas from inulin consumption is normal or correlated with a gut microbe imbalance?
Same here. Supposedly mixing with psyllium will reduce the levels. Or just don't dose it directly and try to get it from natural foods, and see if it still causes issues.
@@jaro6985 I'm curious whether psylium husk by itself would also already have this similar effect. But then the combination might be even more powerful
@@kdemetter it may have a similar effect but does not get digested as much by bacteria the same way inulin does. Part of why it can cause problems. Combination should be best, but I don't know ratios.
I have SIBO and inulin absolutely wrecks my gut so you may want to watch out for any high FODMAP foods to see if you may have SIBO or IBS (they have found that most IBS is actually SIBO though).
Pepto has activated charcoal in it. Is this not the ingredient that is removing the bad bacteria? Could you not just take this instead? Isn't also important to get a diverse microbiome through different strains of probiotics?
Well that is truly fascinating. At least we now know one causal path of GLP-1 inhibition. My mother-in-law used to take Ozempic, I'm just going to tell her to take a couple swigs of Pepto each day 😅
Thanks for the great video. Good news about the inulin, I've been taking 10 grams a day for a few years now, and have been taken psyllium fiber for 20 years or so
Hello Dr. Nick. I love your videos. They are short but pack so much information. I’m wondering if this would also help with fatty liver. I wish you could be my doctor. Thank you so much for doing this.
Maybe i missed it in the video but why exactly does a western diet increase the amount of desulfovibrio? Or rather what is the mechanism behind an increase in desulfovibrio?
U can’t find the magic thing to eat so u can keep eating garbage. Sry. Just like drinking PB will not allow the SAD to be life-giving, energy-producing or disease-inhibiting.
@@nicknorwitzPhD Diets low in sulfur will make sulfur producing bacteria over grow in an attempt to get sulfate into our system. This info is from researcher Stephanie Seneff, a Senior Research Scientist at the MIT. Only problem is if you are low in molybdenum, it will not turn into sulfate instead sulfide. Also seems hard to correct once it's overgrown.
@@Jayla-dj2gj GPT says beef diets have tons of sulfur, but I eat only beef, and there are no metabolic issues with breaking down fats, only sugars and fiber. So, it seems to me that it's pretty simple-give those to cows and let their bacteria do the work, then eat the cow. You can't get any simpler than eating 1 kg of beef a day at lunch in the sun, especially the way I do it: raw. Would be nice to see studies use beef-only as a control group. Can't really mess it up. So many other things have to be included when we make the diet complicated (like toothpaste, alcohol, processed foods, processed sugars and oils, etc.). To do any real experiment, variables must be reduced, especially in the control group.
@@Jayla-dj2gjgreat points! Right now we are trying oil of oregano to knock down the Desulfovibrio colony. And adding molybdenum and B-12 to support sulfur metabolism.
What I got from this video is eat asparagus and agave inulin is not bad, which is surprising because agave in general was once hyped up especially as a sweetener, but the hype declined once folks realized it was high in fructose, and people started avoiding anything with agave. It became an unhealthy food all of a sudden to many people.
Slow release h2s donors regulate demethylation of genes. An imbalance of bacteria causing overproduction might be an issue, but I wouldn't advocate getting rid of those bacteria unless you want to give people cancer. P.S myo-inositol destroying bacteria and excessive palmitate exposure are what causes GLP-1 dysfunction. Fumarate protects mitochondria from excessive h2s.
@@marthavanderpool6829 if fumarate is the same as fumaric acid, it's in a lot of commercial bread as a rough conditioner. So maybe a breadmakers supply shop? Ps I know about fumaric acid cuz it makes my stomach unhappy.
@@marthavanderpool6829 There aren't many supplements that contain fumarate besides Iron Fumarate. Taking Alpha Ketoglutarate boosts Malate and Fumarate levels in your body naturally, though.
Or maybe just eat the natural human diet that requires strong stomach acid, with a lemon on top. If you're gonna ferment your food like a cow then that acid's gonna hurt ya.
Carnivorous diet improves insulin sensitivity but these studies on desulfovibrio say opposite Factors that can increase the amount of Desulfovibrio bacteria in the gut include: A diet high in sulfur-containing foods, such as certain meats, dairy products, and some vegetables A high-fat and low-fiber diet Reduced overall gut microbial diversity, often due to antibiotic use Gastrointestinal conditions that disrupt the normal gut flora
Then you have this: Desulfovibrio can be increased by consuming vegetable and fruit juices that contain sulfhydryl compounds, such as sweet pepper, lemon, tomato, orange, strawberry, melon, and kiwi fruit
gave me food for thought (literally) - you mentioned asparagus in your video, fortunately I really like asparagus, but don't regularly eat it (a few times a year). I ran some prompts by chatgpt concerning inulin fiber, and it provided some interesting answers. I also asked for its sources for its data. could be a good list. Seems the Mediterranean diet could be of benefit here.
Fascinating or crazy? What is crazy is that buying the full text of this paper is more expensive than 1 kg of agave inulin on amazon (in €). So what is the best investment: the paper or the powder? I will trust you and try agave inulin. One more experiment! Any way thank you and please never stop to inform us.
@@nicknorwitzPhDand all books should be a quarter I’ve said that since 1980s. I still stick to a quarter 🪙! If healing should be free, info and wisdom should be free.
Thank you, another great video! What is it about the westernized diet that is detrimental? Not that I disagree but the term seems too general to me. On the other side of that coin, it’s like saying just eat healthy, or everything in moderation.
In every case I have seen every benefit a SCFA has, ketone bodies have too. SCFA are metabolized the same way as ketones or even converted directly to some of the ketones. So unless I see a corresponding RCT which not only uses inulin but also a ketogenic diet (or exogenous ketones) I will assume that ketones do the same...
ok but ketone bodies are produced in the liver not the gut. So a ketogenic diet is not going to necessarily do the same thing, exogenous ketones might.
Thanks (as always) for your research analysis Nick. But please answer this question. I've heard that Pepto Bismol also kills off good gut bacteria. Is this true or false? Google's AI's will give mixed results, I'd rather ask you.
"These results show that a 1- or 2-day course of BSS (bismuth subsalicylate), even with an oral intestinal lavage preparation, did not have significant effects on the normal microbial populations in the fecal microflora." I don't think long term studies exist. But clearly a few days use should be safe.
@@nicknorwitzPhD You probably should make clear that you are NOT recommending Pepto Bismol to increase GLP-1. I see that I am not the only one desperate enough to think of taking it! My quick research shows: It should only be taken for two days, according to instructions on the box. Excessive intake has risk of bismuth toxicity and salicylate toxicity. Also interactions with a long list of prescription and OTC meds.
Thanks. Great Video digging the really interesting bits from a powerful study. Love your desire to seek out root cause. You have to keep looking for new insights - ever curious!. The body is so complex and so many bits matter. One of the many reasons why I am sceptical about “super-specialists” super-focus on one aspect to the exclusion of others misses so much. Medicine has a real problem with “super-speciality” IF your are concerned with overall health of the patient.
That's got me wondering now about how this might be another factor in the positive effects of Prolon (a standardized fasting mimicking diet) which contains inulin at doses people wouldn't usually get daily. Bismuth breaks down candida biofilm too I think.... Thanks for a most interesting video!
Pepto or any of this stuff will dramatically inhibit your Nitric Oxide production. Dr. Nathan Bryan talks about it extensively. I’d think twice about benefits vs harm.
@@nicknorwitzPhD Isn't your point to take more inulin? How is this just an academic exercise...? You didn't say take pepto, you said take inulin... what's this guy going on about? Does inulin really inhibit Nitric Oxide?
I can already see the Pepto bismol being out of stock very soon now 😂 bismol and inulin ay? That's honestly cool. Especially considering some of us (me) are talking Zepbound. And this will help make it work better? Hell yes.
It diet requires a drug or a supplement, the diet is probably a mistake, especially if you think about the fractal nature of multiplying the diet by billions of people.
@@jd01665 Raw meat isn't nutritionally complete, nor is it appropriate for the intermediate GI tract of humans, which are omnivores. Your diet, if you're being honest rather than an evangelist, requires supplementation.
@@drstewart I here your comment "Raw meat isn't nutritionally complete". But it's my experiment, not yours. If you do have any facts to present as far as either deficiencies (there are none) or as far as optimal health (which I would require you to prove also) then feel free to respond, otherwise, I have to assume you've never tried a beef only diet yourself. As I've said, I've done this since 2019 and have almost 5 years under my belt. There are no deficiencies and my health problems are all resolved. I have allergies to a lot of plants and fruits, especially nuts. Not just small allergies, but things like anaphylactic shock type reactions to brazil nuts, etc. So when I realized from the literature that back in the 1800s they had done studies taking individual foods (like beef) and attempted them on volunteer groups of men living in the wilderness where they eat only one thing and found that beef had no drawbacks whereas all the other foods ran short of something, I figured I would try it. 90 days worked amazing and I haven't stopped. I get the beef from a local farm that guarantees grass fed only in France. They guarantee no deforestation and that there are no imported grains, and the cows eat what is on the land natively with all it's diversity. I'm sure you know that plants, even weeds, take different things out of the soil and they are quite diverse. That's what the cow eats and converts in to fat and protein for me.
Please look into more studies regarding Hydrogen Sulfide. Its been a suspect in the development of IBS-D and other gut issues for awhile now. This video goes a long way in simplifying why.
Question: What does Desulfovibrio feed on? What does it flourish or thrive on? Can whatever it feeds on be eliminated from our diets long term? And lastly, does Pepto significantly lower stomach acid ph ? Thanks in advance.
Depends on the strain but some examples: "In the presence of sulphates, desulfovibrios utilize peptones, asparagine, glycine, alanine, glucose, fructose, ethanol, butanol, glycerol, acetate, lactate and malate. Some strains utilize molecular hydrogen as the sole source of energy to reduce sulphate to hydrogen sulphide."
Im pretty new to this topic so i’m spitballing here…If your body digests sulfurous foods poorly, there is a lot of partially digested sulfur for Desulfovibrio to feed on? For instance, Individuals with MTHFR genetic factor don’t do well with sulfur.
@@jaro6985 Nice. Thanks for this explanation. I wondered why TH-cam proposed this video. I only eat raw beef, so no dietary sugars ever and no issues. It was probably all the people discussing sugars in the comments that caused the algo to mention it. Eating plants is difficult. I don't envy you guys. Those cows have four stomachs and can break down the fiber by chewing their food multiple times and using lots of diverse bacteria. Humans can't and I'm not gonna spend more than 30 minutes a day eating and cooking. I'm done in one meal. So I thank the cows for saving me all that time I was spending before when my health was in the bin. Now no deficiencies, supplements, vitamins, not even toothpaste. Go figure. Can't get any more energy dense that beef only, especially once you can get over that the meat is actually clean and you can eat it raw and not waste time cooking. Hard step when we come from families that have studied microbiology and want their food well-done, but I'm over that stage finally and about everything else. I would never use pepto. If the diet needs a supplement or medicine, it's probably not meant for humans, right?
@@jaro6985 You wrote, "No vitamin C or fiber". Let me give you some education. Vitamin C is only needed if you are eating plants. They didn't even bother to measure vitamin C when creating the nutrition tables for meat. And if you honestly think that you have vitamin c in your body but a cow does not, then I have a bridge I can sell you. Fiber is not needed in a human diet. Only ruminant animals can break it down and there is nothing essential inside of carbs/fiber, only water and fat contain the vitamins. You poop the fiber out. Me, I eat only beef, raw, and I only poop a few times a week. The meat literally dissolves in your mouth and digestive tract. Try it yourself. It's not to not need to brush my teeth anymore also.
Taurine increases hydrogen sulfide production via the microbiome. Taurine, however, has recently been touted as a wonder amino. Should I stop taking taurine?
I wouldn't say that... H2S isn't "bad" per se... it's about unbalanced H2S... also did you see my recent video on Pooping calories? If not... check it out... there is a tie in with taurine.
Interesting. I guess this is one of those things one would have to put on a balance? Maybe if you don’t have metabolic syndrome, you are in good health and you don’t eat much seafood at all, maybe it’s better to continue taking taurine. The other thing is, taurine may also help with insulin resistance. Also, hydrogen sulfide has some benefits.
Thank you for the video, at least it confirmed my hydrogen sulfide sibo, yesterday I ate fibers that I know it would make me fatigued and depressed and tried bismol today, which brightened up mood in 2 hours I have been cutting fodmap and fiber in general for months, but it's hard and I know how will I live forever only on meats, white bread, pickled olives, eggs and sugars I tried inulin powder but my stool became very light in color in a week and felt some aches around my stomach that I stopped scarring away from cholestasis
I'd want to see what effects that a non-western diet has such as ketogenic or carnivore diets, both of which change the macro nutrients from starches and sugars to proteins and fats. It's shown that when moving away from starches and sugars, you effectively make the good gut bacteria that live on proteins and fats to flourish while reducing the bad sugar and starch-eating bad bacteria.
It's the gut/microbiome connections. If you want some specific fiber prescriptions, check out the YT channel - Guy Daniels The Microbiome expert. His YT videos are full of the connection between fiber(s) and the health of the microbiome, which then influences many processes in the human body. This is not a new or obscure area. But of course, if you consume junk food and processed foods, well then, just ingesting fiber is not going to be very helpful.
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Funny enough, I had a three month period where I was drinking pepto every other day (not exactly measured, about the equivalent of a swig) due to free coffee at work. I lost a noticeable amount of body fat. After I switched jobs, I gained weight without changing diet/exercise and removing daily coffee/tea consumption. Unfortunately, I had two factors impacting this timeline (coffee/tea and pepto) so I can't say it's due to one or the other since all other variables in my day to day were unchanged. This paper is rather interesting to me due this experience.
pepto study N+1 coming soon from NN?
The active ingredient in Pepto Bismol is bismuth. I've read that blueberries and some other berries also contain it, and I've seen blueberries mentioned as a folk treatment for diarrhea, which is one of the uses of Pepto Bismol.
@@1truemooseBlueberries also contain anthocyanins the purple and blue hue pigment found in many other food (like dark opal basil, sweet onions, purple cabbage) it has been researched to be anti diabetic and may have potential to be anti obesity as well. In some studies it has shown to Ameliorate Mets in a does dependant manner. blueberries also raise NK cells which you need to kill off senescent cells and we are now doing research to reprogram these cells to specifically target sedentary cells. Blueberries consumption was also related to lowering blood pressure and unstiffen blood vessels in one study.
Probably both
Please explain the connection between swigging pepto and free coffee? We don't have pepto in New Zealand.
Nick, I'm a nutrition student from Libya, and let me tell you, if you were to make this claim here, it'd shake the grounds of the entire healthcare system as a whole. They still think eating whole eggs will raise bad cholesterol and that you should only eat egg whites. I'm planning a massive coup against these monochromatic thinking patterns, and I'm more than blessed for having stumbled upon your research. I came here from watching your podcast with Thomas Delaur. You're absolutely awesome and based, man! Keep up the good work Man!
I paid to read this paper via nature.
It was absolutely amazing. I have never read a study that gave so much . I read the first few pages and thought wow- what results and they kept on coming.
As a 1st year undergraduate nutrition student this was amazing for me.
Thankyou for highlighting this paper Nick 🙌
The fact that he would be willing to be sponsored by AG-1 after how thoroughly they have been exposed is troubling.
Thanks for sharing & listening!! 👂
Does the paper shares how much pepto to take or at which times? I am willing to start taking pepto for a month just to try it. I am thinking at night, before bed... perhaps after my last meal too. But I don´t want to pay fo a paper and find out it does not have that info..
@@jimdandy8996 I thought that was supposed to be like a sarcastic joke. Like been truthful but in the nicest way possible
learn what they teach and then learn outside the box. I do holistic nutrition and when my. husband went to a medical nutritionist her info was so bad I almost fainted. About 40 years out of date
Uh WOW! (oh and by the way, I was watching your video very carefully and I have to say with your careful editing [I can see the subtle cuts], and even though your information does come very quickly, there is not a single wasted word. Amazing efficiency in information sharing. Not a single um or ah; no wasted words or mindless repetition. Astoundingly efficient and straight forward. Your careful production and scripting is so impressive and appreciated)
This is so kind 😍. I’ll tell Mark, my editor
I watch at 2x or 3x speed. I don't notice the cuts... LOL
TL:DR You're concise
Yes… no fillers … just enough background, science and practical application to get the job done. Hopefully, the channel won’t eventually go down the typical rabbit hole.
@@ClayCourtGuy I've never been typical...
We need intensive science focus (10,000% increase) on uncovering information like this and totally changing what we allow governments and corporations to do to people bodies.
It's about education and shifting social norms... let's do it together!
Eating correct macros is still in our hands
U have to eat ingredients (very basic foods) only. Don’t worry bout corporations.
Then vote for Trump and Kennedy, because that's what they're aiming to do.
Interesting. Many years ago, I once got into a argument with some health doctor about hydrogen sulfide as being a cause of chronic fatigue system (I was arguing that it was. He wasn't having any part of it). So, all these years later, hydrogen sulfide again pops up. I'm going to say there is some connection with exercise. A quick search shows: exercise increases GLP-1 levels in healthy and obese individuals. I've exercised regularly for years. It's also been many years since I have told anyone I had chronic fatigue. Anecdotal, I know. It might be that exercise isn't increasing GLP-1, but that it is improving hydrogen sulfide metabolism, which in turn fixes other problems.
Wow,Nick. I just subscribed to your channel. You are now on my "I can't miss anything this guy says" list.
Welcome aboard! This is so nice thank you.
@@nicknorwitzPhD same here! Good information, without meandering all over the place! Superb.
@@nicknorwitzPhD remember us little people when you hit 1million subscribers 😎
Note that "Western" diets pre-1960 was vastly different than the same diets today. Most people drank water, soda or other sugar sweetened drinks were a fairly rare treat... as was going out to a fast food place. Carb heavy meals were eaten, but there was little of the "instant" or "quick" carb meals. Packaged meals were the old aluminim foil TV dinners... and were rarely eaten. And while trans-fat margarines and seed oils were fairly common, corn oil was the main one sold, soybean and cotton seed oils still had problems with people having allergies to them, and rapeseed oil was used for lubricant... and you need to wash your hands THOROUGHLY... they had not developed the "safer" canola strains of rapeseed.
Incredible video!! Awesome facts, brilliant delivery, tad bit of humor, tons of enthusiasm!! Bravo, Nick! I hope you can do this forever!! I applaud you!! Thank you! Very cool info. Too many humans are sick and dying from foods we eat (type 2 diabetes, etc..)
Thanks Karen. Appreciate it :).
What I don't like about suggesting that fiber could be a cure is that same short chain fatty acid is produced during intermittent fasting, a superior way to deal with metabolic syndrome. Also, carbs got them into this mess. I'm not sure advocating for more carbs is the best answer that can be found, especially since I just suggested a better one. The entire medical industry's efforts towards GLP-1 are so that people can continue to eat carbs and sugar while having the effects of intermittent fasting. It seems like a lot of trouble just to keep being addicted to carbohydrates. Imagine if we put this much effort into letting people continue to smoke cigarettes? We'd think everybody to be mad. Well, it's just like that but with carbs. It's madness. Stop combining highly refined carbs and vegetable oils together. It's not a difficult concept to follow but it gets rid of people's favorite addictions like pizza and dessert.
Baseless rant.
Fiber is not a simple carbohydrate. Various fibers have been shown to be healthy in large number of studies. Low fiber consumption is linked to cancer.
Fat triggers GLP-1 you don’t need fiber
@@JRCHHH57fiber feeds our micro biome.
I totally agree that intermittent fasting, quality animal fats and protein is the way to go.
Also, for natural GLP-1 inducing supplements- unsmoked Yerba mate tea for your caffeine, the sweetener Allulose and the supplement berberine with meals. Your welcome.
The people who get into weight problems are already having a very hard time functioning. Nothing wrong with a very very cheap low risk pill-much less risk than the new “wt loss” injections. We can encourage them to eat better one step at a time, while taking that simple pill as an aide. Emotional pat issues & current super stressful lives, & even grieving for lost family or friends can trigger intense cravings for carbs-to “naturally” boost feel good
brain chemicals. Helping hurting people with a simple low risk, cheap pill is the right thing to do. If you know someone at risk for health problems because of high wt, you can volunteer to walk with them, or help them with a
gentle resistance or low level wt lifting. You concern is commendable, & I am sure you could be a help to many people. God bless
I was on keto and lost a 30 pounds.
Switching to carnivore 10 months ago, I have lost an extra 25 pounds, while getting more lean mass.
Never felt better and all metrics are perfect. High LDL is the only concern my doctor has (560), but we all know what is going on there…
Have u had it checked since u stopped fat/wgt loss? It takes a month or so to clear from blood after ur done with lipolysis.
I would do a CAC. With a CAC in hand (especially a 0 score). It "relieves" your doctor from carrying you as a non-compliant patient. If he gets too many of those, the insurance company DISCOUNTS his ENTIRE check every month. Our PCP was ready to ask my wife and I to leave his practice to help him out. Wow. We got the CACs and we are compliant with NOT taking statins...
If my LDL was 560 I'd be doing everything possible to try and get it down. But you do you.
@@michaelchristensen2786 Why? If you had a ZERO CAC would you still do that?
Part of the argument is that the PROOF just a high LDL is bad. My brothers was LOW when he had his heart attack.
Ask yourself why insurance companies pay for the drugs. Punish doctors who don't push them. And WILL NOT pay for the CAC which is required for all NASA Astronauts and Fighter Pilots. Because of the value of it's risk assessment...
@@michaelchristensen2786that’s because you believe what your Drs tell you. Statins are more harmful.
If the g.i. System is in an inflammatory state food particles don’t get broken down properly and bits of almost every food you eat can migrate to places they shouldn’t be. Your immune system will see the pieces as invaders and attack them and you will test positive for many food allergies. Once the inflammation has calmed down, the gut wall healed, the microbiome repopulated then you can start reintroducing foods that may have come up positive on a test but you don’t remember having problems with them in the past.
It’s a slow and gradual process to heal. If done deliberately while paying close attention you can probably eventually eat most things you like that are real food in small portions for short periods of time. Being omnivorous can be both useful and enjoyable. It just takes a bit of work to get there.
Why add back food that poisons you? Plants broke your system. Why would you want to add them back. Nobody actually likes them until you add fat or sugar to them. Once you heal your body trust you tastebuds except with sugar. That will always be an addiction to avoid.
Palmitate dysregulates GLP-1.
H2S is an epigenetic signalling molecule that regulates demethylation. Switching genes off. It's absolutely essential.
If it's turning off GLP-1 in the gastrointestinal tract, it just means you are deficient in NO nitrogen oxide, which counter balances h2s demethylation, or you are deficient in fumarate which quanches excessive h2s reactions, or excessive palmitate exposure.
Deficiency in NO has been implicated in the current surge in gastrointestinal cancers in young people as of late.
What does "quanch" mean in this context?
Breathing in through the nose is crucial for nitrogen oxide, why mouth breathing and apnea is so deleterious
Is no2 nitric oxide?
@dfig007 It should have been NO(Nitrogen Oxide) not NO2. I updated it.
Autocorrect caught me out for some reason.
So what's answer 4 diabetes? Fiber
Pepto blocks a lot of things. If you are eating garbage, it is probably just blocking some of the biproducts. What you SHOULD eat, boils down to genetics. A huge problem arises when we generalize . This is true of the food you eat AND your microbiome.
We simply are not all designed the same , and there is no universal chart that is going to work for everyone. For example, I have recently discovered that a carnivore diet is ideal for me at this phase in my development...at least for now. I am not addicted to carbs, so this is actually rather easy for me. At my peak, I was almost a vegetarian . That worked well for me for YEARS, until it didn't.
I was an ultra runner. I ate whatever I wanted( I love veggies like peppers, pumpkins , tomatoes and beans. I like meat, but it's super boring compared to eating a wide variety of veggies.). I never craved sugar or processed food. I preferred to garden and grow my own veggies. I like the idea of producing my own food, but I'm not killing any cows. I am getting meat from local farmers right now.
Aside from hiking and running, growing my own veggies was my favorite hobby.
But I experienced a "perfect storm" about 10 years ago that threw me into a downward spiral. Long story short, they discovered two huge parathyroid adenomas . I had developed an extreme case of hypercalcemia. My body was sucking calcium out of my bones. My blood calcium was so high I had to be hospitalized. They never would have found it had I not broken my wrist.
But was it my diet or lifestyle? Nope. I was living on homemade veggie soup, salad (my favorite food) and lean meat and fish. I was running marathons every weekend and ultras once a month. I felt great for years. However, I have a genetic defect. I have thalassemia trait. This is NOT a disease and it is not that uncommon. It isn't thalassemia. It's just Thal TRAIT. This means that my blood cells don't carry as much oxygen or iron. Technically, this is no biggie. But I was pushing myself to extremes. This is WHY I ate very little meat. A low iron diet was ideal for my genetic make up. I have to be careful about iron overload. But when my body was breaking down, my life was falling apart and I had acquired chronic fatigue, I was still eating mostly carbs...good carbs, .but still carbs. And so, I started getting food sensitivities. Even iceberg lettuce caused me to bloat up like a balloon. My skin was peeling off. I gained weight quickly, even though I had gone down to 1 small meal a day. Ultimately, I decided to do the carnivore diet and it has worked wonders.
However, it would be stupid for me to stay on it forever without "detoxing" from iron from time to time. My kidneys would start failing. That's just a fact. The iron overload would be just as bad or worse as the chronic inflammation caused by the phytonutrients in vegetables. So, for now, I am doing a high fat , low as possible iron diet on meat to detox, but it can't be a permanent lifestyle. Lean proteins like chicken, white meat turkey, cod, mackerel, and salmon are LOWER in iron than red meat . But they all have iron. And iron builds up in people with my genetic make up. Also, those leaner meats contain tons of protein, which has its own problems when you are going near 0 carb.
I hope to eventually be able to properly process some home grown vegetables again without inflammation. Right now, the carnivore diet makes me feel good, but I know it isn't going to be a permanent solution. Iron overload can be a factor in Alzheimer, and that's what I'm trying to avoid.
Everyone is different. If anyone out there has read this far, I have a question. I am trying to do some research on a bacteria called Streptomyces pilosus, a bacterium species from the genus of Streptomyces which has been isolated from soil in Rome in Italy . I specifically want to know how to find it, perhaps in biofertilizer or something, or maybe fish tank friendly bacteria products? But it isn't listed on any products I can find. I was hoping to grow some vegetables in soil enriched with this. I think big pharma is hogging all the data, because they are working on some product this bacteria makes that may delay the onset of Alzheimer's disease. I mean, Streptomyces is everywhere. It's in good soil. But this specific strain creates a specific antibiotic for a specific kind of Alzheimer's caused by the The apolipoprotein E (APOE) gene. I have found some evidence that this gene is often found in people with Mediterranean blood (I'm half Italian) that have thal trait... a trait no doctor anywhere has a clue about and has no advice for other than "don't eat too much meat and never take iron supplements or you could die…but other than that, it's nothing to worry about". Side note: (Weird thought) Isn't it odd that this bacteria in the soil of Rome can cure people specifically from the region that happens to have the highest population of people with a specific blood abnormality? It almost makes me wonder if we all thrive best near the soil of our actual ancestors, because of specific bacterial strains in that soil. But see what I just did? I generalized. The whole point of my post was to point out that generalizations are never accurate.
I enjoyed your post and I agree with the wisdom of not generalizing. We are all different. I do like the idea that coming in contact with our ancient homelands has benefits for our health.
Do you think a 48 hr fast every week help eliminate storing too much iron?
Supposedly there is this element in some part of the soil in Texas. I have read about this as I have one copy of the APO E 4 gene.
@@georgia777 I don't know if I have it, but let me know if you ever find out where in Texas that is. (Texas is pretty big).
@@CarnivoreStork I can't answer that decisively, but I can tell you that eating one meal a day has done wonders for my energy, Fasting off all raw vegetables and carbs for one week actually improved my eyesight significantly (I don't even need my reading glasses while teaching right now, which is totally amazing) and my mood. I am totally guessing here, but I "feel" like this could have something to do with microscopic parasites. If we change things up, it just stands to reason that we would starve off any overgrowth happening from habitual eating. It is for this reason that I don't think carno should be a permanent thing.
This was interesting! I use pepto once in a blue moon and have used inulin for IBS and just ordered some today due to your video.
How did it go?
Ibs-d???
I make a whey powder shake with yoghurt and inulin as well as psylium husk & coacao powder, maca, lecithin.
Lecithin is a great source of choline the deficiency of which is main cause of fatty liver.
People who have hydrogen sulfide SIBO (or SIBO type III) use Pepto bismol as part of their treatment plan, so I'm not surprised by this news. What is surprising is that it helps others not diagnosed with SIBO. Very interesting development that might suggest SIBO type III is related to the more common condition of metabolic syndrome.
I thought this exact point was interesting as well. I have struggled with hydrogen and methane SIBO for decades and I do not have metabolic syndrome and I’ve always been skinny and fit. SIBO is extraordinarily complicated and even more complicated to treat for good. I do think having SIBO and being very health and diet aware has helped me stay lean so that’s the only good thing about SIBO.
@@jillianbaptiste6350 SIBO is a symptom of thiamine deficiency.
Interesting!My diet is 'Carnivorish' (70%+ calories from animal products) but eat lots of onions (inulin rich) and use 5 to 10 gms daily of ground chia seeds (insoluble fiber rich to increase SFA's in lower gut and successfully replace need for electrolyte supplements).
Much happier with onions and chia than with 100% carnivore diet from the perspective of satiety,mental and physical performance and consistent bowel movements.This study reinforces decision.😊
"but eat lots of onions"
onions have a significant amount of fructose...
@@btudrus 1.29 gms/100 gms...
Next to nothing.
@@bobmciver6437 If you eat a kg of onion you get slightly more than what is the recommended daily dosis (25g of sugar = 12.5g of fructose)
When eating an onion, you typically eat a slice, which is minimal carbs, maybe 1-2 grams, at most, as one medium-sized onion has 10.3 grams of carbs (4.7 in sugars). So carbs from onion intake are negligible, unless you're eating a whole onion daily. I eat a slice on my eggs in the am, and it doesn't affect my blood sugar at all. I'm also high-fat carnivore, and the only "veg" I eat is the slice of onion on my eggs every am.
People always trying to be contrarian and difficult.
Get a life, lol.
@@energeticsoulhealer888 There are dishes with a lot of onions. Like Gulash, for example. 1:1 meat to onion...
Love your enthusiasm and cutting edge insights
A beautifully put together, informative video, backed by by scientific fact and actual research, and broken down in a simple way for people to understand. Thank you also for using sane and respectful video headings that is why I "clicked"... Brilliant work!🥇💫
Thank you 😊
Interesting. I’m stage 4 of two types of Lipedema. Lipedema affects mostly women (99% of its victims), causing uncontrolled painful fat production. Where normal fat can release its energy, fat cells affected by this disease cannot. Diet and exercise have little effect on reduction. As an example, I went on 1000 calorie or less per day for two years and GAINED ten pounds.
While a keto or carnivore diet has helped some, anecdotally, Ozempic has been working for most Lipedema patients who’ve tried it. We are working to get the manufacturer-or any scientific body-to officially test it on Lipedema. It would be interesting to test this. Thank you.
I’ve heard astonishing things from carni in women with that
It takes a longgggggg time, but the dysfunction *turns off* and then the excess leaves! I’m talking these women have or are doing this YEARS. 1-2 before the buildup noticeably is leaving. Pain seems to improve within 4-6 mos tho. That must be huge. I’ve had something that caused stinging shooting pain for a longgg time and it was so hard.
I don't know much about this but I do have it, at least 1 genetic marker. It is a very frustrating! My PA has Lipedema and is pretty helpful when I can afford to go!
@@KJB0001 thank you.
@@PurpleLady9555 I have Lipedema in my arms and legs as well. Years ago, I read about fecal transplant from a non “obese” person changing the micro biome. Would love to know if it’s ever been tried on a person with lipedema.
@@PaperMario64 sorry, but I’ve never heard of a fecal transplant. It has never been mentioned in the various international support groups.
This is an interesting video and study. You might want to warn your viewers, though, that taking Pepto-Bismol for an extended period of time can lead to bismuth toxicity.
Not to mention serious constipation.
Do you know how much can cause that in terms of daily amounts? ChatGPT told me this:
Bismuth Toxicity:
Symptoms: Long-term use can cause bismuth encephalopathy, which affects the brain and nervous system. Symptoms include confusion, difficulty speaking, memory problems, and in severe cases, seizures or coma.
Toxic dose: Chronic exposure to bismuth can lead to toxicity, particularly if more than 2 grams per day is consumed over a long period.
@@laserhobbyist9751 Damn, according to ChatGPT, 2 grams of pepto is only .4 of a teaspoon. Guess that diet is a no-go for me
And sticky black stools.
You got a Problem with THAT BIZZZZMUTH!?
The essential oils in caraway seeds have an antimicrobial effect on bad gut bacteria while not affecting good bacteria. Potatoes and rye berries have prebiotics to feed a diverse range of gut bacteria. So i mean, use prebiotics to grow microbes and targeted antimicrobials to suppress the growth of undesirable gut bacteria.
Yes eat mostly plants as we obviously evolved to do, not just bacon and butter.
Thanks I have caraway seeds in my spice collection!
I am guessing that a good time to use Pepto is before bedtime. So as to fight insulin resistance as your blood sugar rises when you sleep. Please correct me.
The paper was done in mice, and there are correlative findings in humans (metabolically unhealthy ones) which is interesting! But I wouldn't call that causative. In the paper with mice sure, but I worry your message is implying causality among every species.
Great video though! Your editing and presentation skills are a level up since the new year!
Thanks for your thoughts. It’s causative in mice with correlation data in humans suggesting the same mechanism could apply. But proving unequivocally causation in humans can be difficult. I listened back and am comfortable with my messaging but I hear you. Thanks. And thanks for the compliment on production value… yes I got new toys 🧸
I have heard some pushback on AG1. Something about heavy metals. I don’t know who to listen to anymore.
People on keto, some on carnivore, intermittent fasting, potato diet, sardine fasting and a plethora of other iterations on how/what to eat. I no longer know what to eat or what’s safe to eat.
Ya right now there’s a lot of pushback. Idk the details. Hope it was clear in the video I was making a joke 😂
Just eat unprocessed food and avoid any extremes. These carnivores are worse than vegans these days, so much so I'm wondering if it's propaganda by meat industry. But there is one thing all of these diets people glorify these days have in common: no processed food.
Also, just the fact that you are paying attention and listening to all these influencers or even competing advice will still point you in the right direction….. which is being mindful of your body. Whether you are eating sardines or vegetables of grass fed beef, because of your interest you are probably not smashing down potato chips and full sugar sodas etc every day.
Just eat natural foods. If you have access to a garden, even better. Then learn as you go along. I started out using the Blood group type diet. It made sense when I came across it since it explained why I had issues with meat, diary and oranges. So I cut them out for many years to clear health issues i had. Then I re-introduced them minimally to my diet.
@@adrianaloborec2205 N1. Experiment and observe how you react. Do not let the Diet Gestapo tell you how to eat.
Wow, more great info I've never heard before. Good stuff!
Thanks 🙏🏻
I wonder which components of the western diet specifically are resulting in the increase in desulfovibrio? There's also some interesting research connections between leptin and gut microbial composition, so maybe there's a way to tie it all together. Could it be an indirect connection, where an obesogenic diet results in leptin resistance, which then negatively alters the gut microbiota? I'm glad you presented this info so that I can explore these questions further.
Well as the saying goes don't shop the centre aisles of the grocery stores because it's all killing you. Shop only the outside areas with fresh produce/meats etc! ONE exception is some stores have bread in the outside area*** walk on by and leave it there, all grains, flour/oats etc, are now toxic chemical dumps thanks to modern farming and will damage your gut bugs.
Honestly. Processed foods are full of so many things. For example, Ice Cream uses trehalose... Since they started it. C. Diff. infections are on the rise. Especially in the older populations. So, our gut microbiome is incredibly complex.
After going carnivore, I stopped getting Sunburn "really easily". I believe it's the removal of the seed oils. Which don't like the sun.
But it could be gut bacteria changed. Or my skin microbiome changed...
It's complicated stuff... Complex Systems have Emergent Behaviors.
Glucose, fructose, or ethanol probably.
@@jaro6985 Not sure about glucose since body makes it's own glucose, xylitol and a few other sugars, but perhaps you are right about fructose and ethanol being key in increasing desulfovibrio. Certainly no sugars in the beef only diet and we seem to fix any metabolic problem with it. That seems to increase the gut biome diversity, not decrease it, as people have been showing their personal biome studies on social media. Very counter-intuitive, but it may be logical if we think about the reduced inflammation of such diets. With the body no longer fighting itself, the blood cells living longer and not being killed by the liver as the blood is purified, it's possible that the gut also benefits. Also perhaps bone and cartilage and organ meats may improve that biome diversity in a way that plants just cannot. Plus a person on beef only is probably also not touching toothpaste, cigarettes, alcohol, and certainly no plants or fruits with pesticides or processed foods and whatever is inside the products they use to make plant-based stuff or clean the containers they ship that stuff in. Sure would be interesting if they were to use beef-only as the control group in all the tests.
"which components of the western diet specifically are resulting in the increase in desulfovibrio?" - high fat diets, according to a 2024 study from the National Academy of Sciences.
Your mention of asparagus as being a source of inulin reminds me of what I read about models who must stay so thin. They eat asparagus and drink asparagus tea to get rid of excess water and bloating.
Point of inquiry: Instead of consuming fiber to produce SCFAs could you just eat foods containing SCFA for the same results such as cheese, butter, ghee, and cow's milk?
I would say yes, the science proves this and many people do not tolerate plant fiber these days. Grass fed dairy is many times more nutritious in everything (especially SCFAs) than grain fed, so that is a notable point.
This is likely linked to C-15. I just saw a video about that. The highest source of C-15 is milk fat.
I cant imagine that would be the same.
@@kj_H65f why?
it may not all reach the colon. whereas many fibres do.
Aside from people thinking they now need Pepto, this information is intriguing and reinforces what many people already know. Good stuff 👍👍
That's really interesting however if you are allergic to Aspirin you shouldn't take Pepto-Bismol.
I’m allergic to aspirin. What’s the correlation with pepto bismol?
Yes those with a salicylate/ aspirin sensitivity or allergy would not respond well to Pepto...
This is interesting as sulphur helps with the detoxification of salicylate...
No one should take pepto. Goodness.
Thank you for this. It probably answers the question of why people who primarily get their calories from inulin tend to lose weight and those who primarily get their calories from starch tend to gain weight. I have inulin powder already, so I was able to figure out that 1 tsp of my powder weighs 5g.
Not true. If you research starch as in the book “Starch Solution”, combining starch and fats, then yes. You can live on potatoes and lose weight, get off insulin, statins etc
WOW NICK... You just dropped a bomb brother. My 5 year old daughter has metabolic syndrome amd many times we are im awe that she doesn't seem to register a "full" signal. Will definitely try!!!! Thank you as always brother.
Pepto is dangerous for kids
Let's cut to the chase Doc, how much Pepto should we all be consuming? (yes, I said it, but know you're all thinking the same thing) BTW, I don't eat McDonalds, following a keto/carnivore plan. But have had a lifelong struggle with obesity.
U don’t need it if ur healing ur root cause already
On carni or very strict keto u heal
@@furbytomo2562 Yes, I have asked the same question, and for how long can you consume it at the recommended dosage? The UK NHS Website advice (not a reliable source of info IMO) says no more than two days.
Wow! Wow! Wow! Wow! I can't wait for more on this topic! It is exciting that studies like this one are enlightening us about (potentially) how we got so sick and fat and (potentially) how we might reverse it without meds!!! This one hits home for me and nearly made me tear up! Thank you, Nick! Keep up the good work, please!💜
This is beautiful thank you!
@@nicknorwitzPhD Is there any research on becoming GLP1 resistant from taking GLP1 meds? I wonder if that is why the does has to increase to keep the same effect--reminds me of insulin resistance??? If so, how do we find a balance?
Dose not "does" sorry!
Another question, will the mitochondria heal or regenerate naturally with the reduction of the hydrogen sulfate or are things we need to do to restore their function?
Good stuff! I love the taste of pepto, I could drink it as a desert. I swear I have that same bed frame, it was built by my grandfather, common design back in the day :).
If a diet results in less gas and in particular unpleasant smelling sulphur containing gas, does this mean that you are on the right path.......seams an obvious answer to me.
Inulin is the polysaccharide that gives you gas in beans and sunchokes.
I'd wager the bacteria that breaks down the inulin is overpowering the HS producing bacteria by having a food source, plays a role.
No gas on raw beef only as far as I can tell. Heck, I don't even use the toilet but a couple times a week. The meat just seems to dissolve. Guess I found the right one? What 'bout you?
@@jd01665 they're speaking to HS producing bacteria.
So the question is does the bacteria exist on a carnivore diet, and if so is it more or less than a diet with inulin.
Doesn't sound like this study addresses this, so can't really say.
@@Unsensitive Thank you. Yes, it seems to not be addressed as to whether beef only is a good solution and why. Certainly telling people Pepto is a solution is crazy because they say not to consume it long term since it lowers your stomach acid levels and that can affect your risk of heart disease because you will have less nitrogen oxide in your blood and risk to have more clotting.
@@JessieJussMessy Only a fool believes that meat doesn’t dissolve in the stomach. How do we know? Two ways. One is you can put stomach acid in a container and test it. Second is if you do a quick search on TH-cam you will find people that have colon cancer from plants and they now have bags instead of a colon and they say that the bags are empty when they eat meat.
Fascinating as I have metabolic syndrome and can’t seem to lose any weight. So frustrating.
So sorry to hear that. You may find tips/ideas/answers on these channels: @KenDBerryMD , @myzerocarblife , @anthonychaffeemd
Work on your microbiome: green bananas, eat wide variety of fruits and veggies, potato starch, insulin, etc.
Metabolic Syndrome used to be called "Insulin Resistance Syndrome." Why the change? Too much Insulin is/has been the issue all along.
@@Scottlp2did you mean “inulin” not “insulin”?
@@pilotrtc Channels of liars, do not follow those. On the top, have you seen the video? It's about fiber, not about eating meat. You are just a clown.
Hi Nick, as always a very informative video 👍 What daily dosage of Pepto Bismol would be required in order to secure the benefits you cite? Also, for how many days can you safely take PB at your recommended dosage? The UK NHS website (much of the advice on which is very suspect) suggests that you should not take for more than two days...what do you say? Thanks in advance, Anthony
Ways to Use Chicory Root
There are numerous ways to use chicory root. These include:
Using it as a powder as a coffee substitute
Using the powder as an addition to regular coffee
Blending the powder with other spices to make a tea
Adding the powder to smoothies or oatmeal
I'm enjoying my chicory coffee right now!
Thanks for the thoughts.
Downside to making liquids with it is you are missing most of the inulin fiber. I would never eat oatmeal but that was the only one you mentioned that would get you all its healthy fiber.
@@koala-py7uy I simply like the taste...
@@mattlevault5140 No worries, I was just mentioning that to get the inulin you need to consume the stuff, since 3 of the OPs 4 uses were liquid based.
Awesome video! Great presentation and to the point, not inflated 😌
Glad you enjoyed it!
Have you done a video on seed oils yet? The book Dark Calories makes a compelling case
Marvelous information well presented. About how much Pepto Bismol should I be taking daily? I've been keto, with intermittent fasting usually 16:8 for a long time.
Caraway seeds are fried and eaten with salt and rice for bad tummy in india even today
Wow a huge amount of useful information in a short amount of time. Thank you
Thanks 😊
Nick, a certain Professor Rachel Batterham did a study and research into satiation hormones.
She found that a breakfast of 50g whey each morning raised GLP-1 & PPY levels enough to stop the patients from feeling hungry, after a eating anormal sized meal. They lost weight of course, and this meant the NHS could save billions from performing gastric-bypass surgeries in the long run.
So, protein vs meds, and food wins.
Nick, you are smart, curious and amazingly focused on the science of a healthy diet. It would be wonderful if you could work with RFK Jr. on improving the health of our nation!❤
It makes sense that feeding good prebiotic fibers to your gut will help keep the right bacteria alive vs UPF that is known to kill your microbiota
I hate inulin because it makes me so gassy. I'm a thin guy so not worried about obesity, but can you comment on whether the gas from inulin consumption is normal or correlated with a gut microbe imbalance?
I would say abnormal gut
Same here.
Supposedly mixing with psyllium will reduce the levels.
Or just don't dose it directly and try to get it from natural foods, and see if it still causes issues.
@@jaro6985 I'm curious whether psylium husk by itself would also already have this similar effect. But then the combination might be even more powerful
@@kdemetter it may have a similar effect but does not get digested as much by bacteria the same way inulin does. Part of why it can cause problems. Combination should be best, but I don't know ratios.
I have SIBO and inulin absolutely wrecks my gut so you may want to watch out for any high FODMAP foods to see if you may have SIBO or IBS (they have found that most IBS is actually SIBO though).
Brilliant. Some of the most interesting research I have been exposed to ever.
To answer the question in my previous comment look up Dr. Tyna, I've heard it in the Mind Pump podcast, those guys tried it and it helped them.
This is wild news! Thanks for sharing!!!🎉
You bet!
This is a BERY interesting study. Thank you for explaining it clearly.
You’re 🫐 welcome
Pepto has activated charcoal in it. Is this not the ingredient that is removing the bad bacteria? Could you not just take this instead? Isn't also important to get a diverse microbiome through different strains of probiotics?
Well that is truly fascinating. At least we now know one causal path of GLP-1 inhibition.
My mother-in-law used to take Ozempic, I'm just going to tell her to take a couple swigs of Pepto each day 😅
Thanks for the great video. Good news about the inulin, I've been taking 10 grams a day for a few years now, and have been taken psyllium fiber for 20 years or so
Hello Dr. Nick. I love your videos. They are short but pack so much information. I’m wondering if this would also help with fatty liver. I wish you could be my doctor. Thank you so much for doing this.
Wow, Nick! This was a great video!
Thanks. Appreciate it.
Sauerkraut is a good source of inulin. It's prebiotic and fermented, both of which are good for us.
Love Sauerkraut
Super Interesting! Many thanks for sharing Nick.
Glad you enjoyed it!
@@nicknorwitzPhD All your content is awesome! Thanks again
Maybe i missed it in the video but why exactly does a western diet increase the amount of desulfovibrio? Or rather what is the mechanism behind an increase in desulfovibrio?
I wish I knew... yes... that's a link that's not quite precisely defined. Astute observation.
U can’t find the magic thing to eat so u can keep eating garbage. Sry.
Just like drinking PB will not allow the SAD to be life-giving, energy-producing or disease-inhibiting.
@@nicknorwitzPhD Diets low in sulfur will make sulfur producing bacteria over grow in an attempt to get sulfate into our system. This info is from researcher Stephanie Seneff, a Senior Research Scientist at the MIT. Only problem is if you are low in molybdenum, it will not turn into sulfate instead sulfide. Also seems hard to correct once it's overgrown.
@@Jayla-dj2gj GPT says beef diets have tons of sulfur, but I eat only beef, and there are no metabolic issues with breaking down fats, only sugars and fiber. So, it seems to me that it's pretty simple-give those to cows and let their bacteria do the work, then eat the cow. You can't get any simpler than eating 1 kg of beef a day at lunch in the sun, especially the way I do it: raw. Would be nice to see studies use beef-only as a control group. Can't really mess it up. So many other things have to be included when we make the diet complicated (like toothpaste, alcohol, processed foods, processed sugars and oils, etc.). To do any real experiment, variables must be reduced, especially in the control group.
@@Jayla-dj2gjgreat points! Right now we are trying oil of oregano to knock down the Desulfovibrio colony. And adding molybdenum and B-12 to support sulfur metabolism.
What I got from this video is eat asparagus and agave inulin is not bad, which is surprising because agave in general was once hyped up especially as a sweetener, but the hype declined once folks realized it was high in fructose, and people started avoiding anything with agave. It became an unhealthy food all of a sudden to many people.
Slow release h2s donors regulate demethylation of genes.
An imbalance of bacteria causing overproduction might be an issue, but I wouldn't advocate getting rid of those bacteria unless you want to give people cancer.
P.S myo-inositol destroying bacteria and excessive palmitate exposure are what causes GLP-1 dysfunction.
Fumarate protects mitochondria from excessive h2s.
He said its a picture not the whole picture
I don't think he said anywhere that eating inulin would completely "get rid of" that bacteria.
How does one get fumarate?
@@marthavanderpool6829 if fumarate is the same as fumaric acid, it's in a lot of commercial bread as a rough conditioner. So maybe a breadmakers supply shop? Ps I know about fumaric acid cuz it makes my stomach unhappy.
@@marthavanderpool6829 There aren't many supplements that contain fumarate besides Iron Fumarate.
Taking Alpha Ketoglutarate boosts Malate and Fumarate levels in your body naturally, though.
This was great. Thanks Nick.
Glad you enjoyed it!
Hi Nick, like your rugby ball in the background!
Or maybe just eat the natural human diet that requires strong stomach acid, with a lemon on top.
If you're gonna ferment your food like a cow then that acid's gonna hurt ya.
Also people with sibo often respond to inulin with gas and bloating. You could try introducing slowly. It's in quite a few fibre mixes
Carnivorous diet improves insulin sensitivity but these studies on desulfovibrio say opposite Factors that can increase the amount of Desulfovibrio bacteria in the gut include:
A diet high in sulfur-containing foods, such as certain meats, dairy products, and some vegetables
A high-fat and low-fiber diet
Reduced overall gut microbial diversity, often due to antibiotic use
Gastrointestinal conditions that disrupt the normal gut flora
Then you have this: Desulfovibrio can be increased by consuming vegetable and fruit juices that contain sulfhydryl compounds, such as sweet pepper, lemon, tomato, orange, strawberry, melon, and kiwi fruit
Dude, production value continues to impress
Cheers mate
Hello Nick. Mate this is a awesome video!!! This one gets shared for sure! Andre
Glad you enjoyed it! Thanks 🙏🏻
@nicknorwitzPhD I found you on Facebook and TH-cam. Take it easy. I got tiles to lay. They don't lay themselves haha. Andre
gave me food for thought (literally) - you mentioned asparagus in your video, fortunately I really like asparagus, but don't regularly eat it (a few times a year). I ran some prompts by chatgpt concerning inulin fiber, and it provided some interesting answers. I also asked for its sources for its data. could be a good list. Seems the Mediterranean diet could be of benefit here.
Great info! Thank you
Interesting -- thanks, you keep feeding my curiosity bugs.
Any time! I am to curiosity as French fries are (presumably) to Desulfovibrio ;)
Fascinating or crazy?
What is crazy is that buying the full text of this paper is more expensive than 1 kg of agave inulin on amazon (in €).
So what is the best investment: the paper or the powder? I will trust you and try agave inulin. One more experiment!
Any way thank you and please never stop to inform us.
I think all papers should be open access... if I ruled the world...
@@nicknorwitzPhDand all books should be a quarter
I’ve said that since 1980s. I still stick to a quarter 🪙!
If healing should be free, info and wisdom should be free.
@@nicknorwitzPhD Who would pay for research if it's all open access?
This is great Nick. Very interesting to say the least.
Glad you think so mike!
Very interesting I’d like to hear more about this
Thank you, another great video!
What is it about the westernized diet that is detrimental? Not that I disagree but the term seems too general to me. On the other side of that coin, it’s like saying just eat healthy, or everything in moderation.
I wish I knew... yes... that's a link that's not quite precisely defined. Astute observation.
Wow does this tie in some much I’ve been dealing with - thank u!❤
🙏🏻😉😊🙏🏻
Nick, excellent video
Is it true that Yerba Mate increases GLP1? A video on that would be great!
In every case I have seen every benefit a SCFA has, ketone bodies have too.
SCFA are metabolized the same way as ketones or even converted directly to some of the ketones.
So unless I see a corresponding RCT which not only uses inulin but also a ketogenic diet (or exogenous ketones) I will assume that ketones do the same...
ok but ketone bodies are produced in the liver not the gut. So a ketogenic diet is not going to necessarily do the same thing, exogenous ketones might.
@@jaro6985 Ketones get there through the cirulation.
Thanks (as always) for your research analysis Nick. But please answer this question. I've heard that Pepto Bismol also kills off good gut bacteria. Is this true or false? Google's AI's will give mixed results, I'd rather ask you.
I'd say it's possible... to be clear... the Pepto thing was a bit of a joke... I don't recommend it as an intervention... you'd be gambling.
"These results show that a 1- or 2-day course of BSS (bismuth subsalicylate), even with an oral intestinal lavage preparation, did not have significant effects on the normal microbial populations in the fecal microflora."
I don't think long term studies exist. But clearly a few days use should be safe.
@@nicknorwitzPhD You probably should make clear that you are NOT recommending Pepto Bismol to increase GLP-1. I see that I am not the only one desperate enough to think of taking it! My quick research shows: It should only be taken for two days, according to instructions on the box. Excessive intake has risk of bismuth toxicity and salicylate toxicity. Also interactions with a long list of prescription and OTC meds.
Thanks. Great Video digging the really interesting bits from a powerful study. Love your desire to seek out root cause. You have to keep looking for new insights - ever curious!. The body is so complex and so many bits matter. One of the many reasons why I am sceptical about “super-specialists” super-focus on one aspect to the exclusion of others misses so much. Medicine has a real problem with “super-speciality” IF your are concerned with overall health of the patient.
I agree… most of the time… then again… if you need a liver transplant you kind of do want the best in the world super specialist
Here's what the metabolically challenged heard: "Eat that pizza, ice cream, and cake. Just take pepto bismol and you'll be nice and healthy." 😂
That's got me wondering now about how this might be another factor in the positive effects of Prolon (a standardized fasting mimicking diet) which contains inulin at doses people wouldn't usually get daily.
Bismuth breaks down candida biofilm too I think....
Thanks for a most interesting video!
Pepto or any of this stuff will dramatically inhibit your Nitric Oxide production. Dr. Nathan Bryan talks about it extensively. I’d think twice about benefits vs harm.
I'm not saying go buy Pepsi Bismol and eat McDonald's... but it is fascinating... consider it an academic exercise...
Google doesn't find any study relating the two, can you provide a reference?
I tried to reply 2 times. Doesn’t seem to go through.
@@nicknorwitzPhD Isn't your point to take more inulin? How is this just an academic exercise...? You didn't say take pepto, you said take inulin... what's this guy going on about? Does inulin really inhibit Nitric Oxide?
@@vadimkravets9209 links dont work so you'd have to just post the title of the study or PMID if you wanted.
I can already see the Pepto bismol being out of stock very soon now 😂 bismol and inulin ay? That's honestly cool. Especially considering some of us (me) are talking Zepbound. And this will help make it work better? Hell yes.
It diet requires a drug or a supplement, the diet is probably a mistake, especially if you think about the fractal nature of multiplying the diet by billions of people.
@@jd01665 Raw meat isn't nutritionally complete, nor is it appropriate for the intermediate GI tract of humans, which are omnivores. Your diet, if you're being honest rather than an evangelist, requires supplementation.
@@drstewart I here your comment "Raw meat isn't nutritionally complete". But it's my experiment, not yours. If you do have any facts to present as far as either deficiencies (there are none) or as far as optimal health (which I would require you to prove also) then feel free to respond, otherwise, I have to assume you've never tried a beef only diet yourself. As I've said, I've done this since 2019 and have almost 5 years under my belt. There are no deficiencies and my health problems are all resolved. I have allergies to a lot of plants and fruits, especially nuts. Not just small allergies, but things like anaphylactic shock type reactions to brazil nuts, etc. So when I realized from the literature that back in the 1800s they had done studies taking individual foods (like beef) and attempted them on volunteer groups of men living in the wilderness where they eat only one thing and found that beef had no drawbacks whereas all the other foods ran short of something, I figured I would try it. 90 days worked amazing and I haven't stopped. I get the beef from a local farm that guarantees grass fed only in France. They guarantee no deforestation and that there are no imported grains, and the cows eat what is on the land natively with all it's diversity. I'm sure you know that plants, even weeds, take different things out of the soil and they are quite diverse. That's what the cow eats and converts in to fat and protein for me.
Please look into more studies regarding Hydrogen Sulfide. Its been a suspect in the development of IBS-D and other gut issues for awhile now. This video goes a long way in simplifying why.
Great overview.
Question: What does Desulfovibrio feed on? What does it flourish or thrive on?
Can whatever it feeds on be eliminated from our diets long term?
And lastly, does Pepto significantly lower stomach acid ph ?
Thanks in advance.
Depends on the strain but some examples: "In the presence of sulphates, desulfovibrios utilize peptones, asparagine, glycine, alanine, glucose, fructose, ethanol, butanol, glycerol, acetate, lactate and malate. Some strains utilize molecular hydrogen as the sole source of energy to reduce sulphate to hydrogen sulphide."
Im pretty new to this topic so i’m spitballing here…If your body digests sulfurous foods poorly, there is a lot of partially digested sulfur for Desulfovibrio to feed on? For instance, Individuals with MTHFR genetic factor don’t do well with sulfur.
@@jaro6985 Nice. Thanks for this explanation. I wondered why TH-cam proposed this video. I only eat raw beef, so no dietary sugars ever and no issues. It was probably all the people discussing sugars in the comments that caused the algo to mention it. Eating plants is difficult. I don't envy you guys. Those cows have four stomachs and can break down the fiber by chewing their food multiple times and using lots of diverse bacteria. Humans can't and I'm not gonna spend more than 30 minutes a day eating and cooking. I'm done in one meal. So I thank the cows for saving me all that time I was spending before when my health was in the bin. Now no deficiencies, supplements, vitamins, not even toothpaste. Go figure. Can't get any more energy dense that beef only, especially once you can get over that the meat is actually clean and you can eat it raw and not waste time cooking. Hard step when we come from families that have studied microbiology and want their food well-done, but I'm over that stage finally and about everything else. I would never use pepto. If the diet needs a supplement or medicine, it's probably not meant for humans, right?
@@jd01665 Meat only diet definitely needs supplements as its not nutritionally complete. No vitamin C or fiber.
@@jaro6985 You wrote, "No vitamin C or fiber". Let me give you some education. Vitamin C is only needed if you are eating plants. They didn't even bother to measure vitamin C when creating the nutrition tables for meat. And if you honestly think that you have vitamin c in your body but a cow does not, then I have a bridge I can sell you. Fiber is not needed in a human diet. Only ruminant animals can break it down and there is nothing essential inside of carbs/fiber, only water and fat contain the vitamins. You poop the fiber out. Me, I eat only beef, raw, and I only poop a few times a week. The meat literally dissolves in your mouth and digestive tract. Try it yourself. It's not to not need to brush my teeth anymore also.
Awesome video
Thanks :)
OMG --- i researched gut hydrogen sulphide before wrt mitochondria - why were we not taught this !
Taurine increases hydrogen sulfide production via the microbiome. Taurine, however, has recently been touted as a wonder amino. Should I stop taking taurine?
I wouldn't say that... H2S isn't "bad" per se... it's about unbalanced H2S... also did you see my recent video on Pooping calories? If not... check it out... there is a tie in with taurine.
@@nicknorwitzPhD I probably did, but I will review. Thanks, Nick.
Interesting. I guess this is one of those things one would have to put on a balance?
Maybe if you don’t have metabolic syndrome, you are in good health and you don’t eat much seafood at all, maybe it’s better to continue taking taurine.
The other thing is, taurine may also help with insulin resistance.
Also, hydrogen sulfide has some benefits.
Would the hydrogen sulfide make someone’s farts smell like rotten eggs? Or is the best answer to such questions, “None of you bismuth“? 😂
Omigosh
U made me laugh 🤣
I love your pun! It’s eggcellent
Yes it would. Molybdenum should be used to help turn the sulfide into useable sulfate and stop eating anything that causes the gas until healed.
there are numerous sulfur containing gases, not just hydrogen slfide. plus other things the microbiome produces that can create smell.
None of your bismuth
I wonder though if taking Pepto everyday would cause persistent constipation.
Interesting content. Is there a video where he shows us his diet?
Me? I do not have a “what I eat in a day” video.
@@nicknorwitzPhD too bad that would be interesting.
Someone needs to show this to the Carb Addict Doctor.
Thank you for the video, at least it confirmed my hydrogen sulfide sibo, yesterday I ate fibers that I know it would make me fatigued and depressed and tried bismol today, which brightened up mood in 2 hours
I have been cutting fodmap and fiber in general for months, but it's hard and I know how will I live forever only on meats, white bread, pickled olives, eggs and sugars
I tried inulin powder but my stool became very light in color in a week and felt some aches around my stomach that I stopped scarring away from cholestasis
Whatever the mechanism, if you’re trying something new and it’s working for you, then I’m happy for you
I'd want to see what effects that a non-western diet has such as ketogenic or carnivore diets, both of which change the macro nutrients from starches and sugars to proteins and fats. It's shown that when moving away from starches and sugars, you effectively make the good gut bacteria that live on proteins and fats to flourish while reducing the bad sugar and starch-eating bad bacteria.
It's the gut/microbiome connections. If you want some specific fiber prescriptions, check out the YT channel - Guy Daniels The Microbiome expert. His YT videos are full of the connection between fiber(s) and the health of the microbiome, which then influences many processes in the human body. This is not a new or obscure area. But of course, if you consume junk food and processed foods, well then, just ingesting fiber is not going to be very helpful.