Thank you so much for this video! I had pancreatitis a few years ago and may have chronic pancreatitis now. My mother passed away from pancreatic cancer last year, so this topic hits close to home. I’m currently on a keto diet, and while it’s frustrating to know that pancreatic cancer can be resistant to keto, I’m incredibly thankful for this new information on combining a ketogenic diet with an eIF4E inhibitor. It’s so encouraging to see new potential ways to fight this cancer!
Ok, Nick, now all you have to do is tell us how to activate the 4E inhibitor, and we can cure pancreatic cancer! Snap! I always watch your posts, and yeah, sometimes you get slightly technical, but you provide way more info and divergent subjects than most of the sites, with the possible exception of Nic on Physionics. The two of you must attend the same comedy workshop, the jokes are worth the price of admission.
Too bad I lost trust in medical research. We knew from the 60s about Keto, and food pyramid is still pushed on us. There are entire aisles in Grocery store that should be illegal and there are still advertised as heart healthy. 🤨
What's insane to me is how some companies somehow get away with no nutrition fact label or blatantly false info on their nutrition facts. Like how a zero calorie Gatorade is only zero calories because they defined a serving as ½ a bottle but then the cals per bottle are 5. That math ain't mathing. Makes me now suspicious of everything that claims to be zero calorie.
There’s a loophole in nutrition labeling rules that they can declare 0 calorie if the protein contains 2.5 calories or less per serving. Sometimes I imagine everyone should be a lawyer so we don’t fall prey to many loophole in law and regulations.
So GLAD you brought up the benefits of seeds oils like tahini. Everybody just thinks they are the devil, but as long as they aren't refined, I have no problem with them. I'm starting keto today, so I will be purchasing some tahini to help jump start it, thanks for the hack nick!
Dr Bikman discussed which fats are best to generate ketones in one of his videos. His position is that body can't store shorter chain fatty acid (8C or under) so they are turned into ketones. According to him this is why MCT oils are so effective for raising ketone levels. Oleic and Linoleic are both C18. How does it work then?
I’ve read widely about and been in ketosis for most of the last twenty years but this is the first I’ve heard about the sesame oil/butter ability to ramp up the ketones. I really enjoy your vlogs; thank you for making all this incredible content.
First ... poor mouse . I had pet mice as a kid . Second ... your channel is so fascinating. Third ... it's a weird experience to go to the GP and realize they are lagging so far behind in their knowledge of metabolic health .
Very cool. I stumbled onto nuts, simply because I have always been a keto vegetarian and as a keto vegetarian, I needed to get enough calories to cover my 2400kcal BMR and nuts were one of the only plant fat sources with sufficient caloric density to allow me to meet my requirements without overstuffing. I was not aware that the nuts were direcrly contributing to my ability to rapidly switch into ketosis.
Very high in oxalate and phytosterols which disrupt hormones and are highly oxidizable Not to mention nuts combine carbs fat and protein which actually drives insulin very high not a healthy thing for us
Ironically a lot of keto influencers have demonized Omega-6 fats in recent years just because of a few manufactured oils. Many of the personal trainer gym bros who've only read their study guides and can only parrot back calories also say nuts are bad and probably the best reason to eat a variety of nuts. My TSH is too low and been eating brazil nuts lately for the selenium and i've heard people say to avoid them due to the omega-6 content
omega6s compete with imega3s for consversion/absobtion. Since Omega 3s are beneficial and limiting omega6s can be easier for some people than upping omega 3s, it might not be so wild. I have heard tho thatit's only ALA that competes since it needs to be converted to EPA or DHA to be "usefull", so this might not apply if your omega3 source is from fish, eggs etc
I know you said that LA increases ketones, and then conveniently had a blurp about not bringing up seed oils, but I am curious if there would be any ketone increase if you use seed oils compared to butter or if it would be even worse. Seed oils have high levels of LA. Just a thought experiment I guess because I don't think anyone would try it.
@@tedarcher9120 i love this guy,,,,I have a hard time keeping up with him though..,,..I have no education on any of this, so I want to understand it….but it’s hard for me…no complaints here,.he’s great, He knows the science…..it just goes over my head
5:15 How long and stable is the increase? Do polyunsaturated fats get a priority when it comes to fuel because they're less stable when kept around (e.g. polyunsaturated = liquid jet fuel; saturated fat = solid jet fuel)?
Very interesting 😮 I wonder if it's the longer chains of fatty acids that instigates the metabolism to burn more fats. What if one was to try mustard oil, which has VLCFA. It's high in erucic and brassic acid, which have 22 and 24 carbon chains?
(actually, glutamine) and he said he is looking for cancer cells that can use anything else beyond glucose and glutamine for energy, maybe Nick should talk to Dr Seyfried ;)
So if I understand this correctly would MCT oil also be a good substitute for the sesame seed oil in raising ketones so much so that it is better than butter as well?? Great content!!
I can't eat most plant material, but if I want to increase ketones fast then I eat MCT or just plain coconut oil. MCT is faster but coconut oil is just as reliable and last a little longer.
Goat butter has higher levels of MCTs. I use cultured goat butter from Mt. Capra. The culturing breaks down the fat molecules and makes them more quickly bioavailable. So, goat butter should be one of the most ketone-boosting sources of fats around. Also, consider that monogastric animals will store whatever fats they eat. If pigs and chickens are fed linoleic acid and MCTs, that is what fat will be available in the foods procured from them: meat, eggs, lard, etc. But such foods would be hard to find on the mainstream market.
I only heard him talk about LA being more ketogenic than butter, and hinted that unsaturated fats would be more ketogenic that saturated. Since MCT oil is virtually all saturated, why do you think MCT would be more ketogenic?
@@mlaroche2009 - We know from old and well established research that MCTs are easily and rapidly converted into ketones in the liver. It's been a common practice to use MCTs in the medical application of the keto diet to treat disease.
Down the road from us is a farmer-nutritionist who has a laboratory right on his farm. He swears by a daily regimen of butter, eggs and tahini because it contains the much overlooked EIEIO inhibitor. His name is MacDonald.
Have you tried your hack to raise your ketone levels using olive oil rather than nut butters considering olive oil has a substantial amount of linoleic acid?
Compared to butter and tahini, how would coconut oil or macadamia nuts stimulate or inhibit ketosis? I’ve heard many times that coconut oil is related to MCT oil, which is good for stimulating ketosis.
SO tahini isnt better than sunflower unprocessed oil? Its just seeds oils that make the hack work? Wasnt really clear from the video. I can choose for example olive oil??
Sesame oil are often sold mix with other oil. Why? because its expensive and difficult to extract oil from them. You can find REAL 100% pure sesame oil but its really expensive. Yes more expensive than virgin olive oil and very short expiry date.
What about the claims that linoleic acid is bad for us?... That it causes heart disease etc. I'm talking about unprocessed unrefined unoxidized linoleic acid of course.
If I understand correctly, the ideal ratio omega3 to omega6 is one, so if you eat a table spoon of sesame seed oil, take a spoon of fish oil (roughly, depends of course on the omega6 content of sesame seed oil and omega 3 content of your fish oil). Would be interesting for Nick to see if he still reaches his high level of ketones this way...
i've heard the same but the data is really sketchy and probably relies on a few manufactured seed oils and not on the variety of natural omega-6 sources out there
Omega-6s easily oxidize, both on the shelf and in the body. This increases oxidative damage, inflammation, and mutagenesis. Something can be healthy in one way and potentially unhealthy in another. Also, it's a matter of degree. Using linoleic acid in small amounts or occasionally is far different than consuming it in large amounts every day. You could try to balance omega-6s with omega-3s, except omega-3s also oxidize easily. It's possible that, instead of omega-3s, you might be able to consume linoleic acid with C15 that has many of the same benefits as omega-3s and may be even more beneficial. But I don't know of any research on how linoleic acid and C15 interact. I don't know if linoleic has any advantage over MCTs. After all, MCTs have all the benefits and none of the downsides of linoleic acid. Plus, one can get higher levels of MCTs from a variety of sources, including goat butter and ghee. Plus, if it's cultured goat ghee, it has smaller fat molecules that are more bioavailable. It's possible this would be even more beneficial right before a fast. I get my cultured goat ghee from Mt. Capra.
People you dont need meat. I eat vegan keto combined with a lot of bryan johnson. Really good healthmarkers and even delicious eating. You really really dont need it. Just some skills, cooking, using a freezer etc..
In ancient Greece, athletes ate meat, cheese, and barley to build bodies strong enough to wrestle lions-now we’re wrestling snack cravings and wondering why we’re weak. If the Greeks could fuel empires on real food, what in the world makes us think a diet of processed junk will Make America Healthy Again? Sometimes the wisest move is the simplest-eat like the ancients, not like a vending machine.
Linoleic acid, like all PUFAs (omega-6s and omega-3s), are easily oxidized both in processing and in the body. This means they cause oxidative damage, inflammation, and mutagenesis. One would be advised to not consume them excessively and regularly. But they might be fine to promote ketosis on occasion. Then again, MCTs will promote ketosis without any of the oxidative problems. One can get more MCTs from coconut oil or goat butter and ghee. I'm not sure linoleic acid has any advantages, in this case.
If you’ve had hummus, you’ve had it. It gives the somewhat “nutty” flavor in hummus. It’s just ground up roasted sesame seeds. I think it’s delicious, of course, taste is a very subjective thing.
Our genome only encodes for 20-25k proteins. With splice variants that may be taken up to 80-100k but I'm not sure if it's actually over 100k different proteins.
![โรงเรียนดัดสันดาน นักเรียนเถื่อน..!! [โรงเรียนไดเม่]](http://i.ytimg.com/vi/vRKPeXn4Fl4/mqdefault.jpg)
Thank you so much for this video! I had pancreatitis a few years ago and may have chronic pancreatitis now. My mother passed away from pancreatic cancer last year, so this topic hits close to home. I’m currently on a keto diet, and while it’s frustrating to know that pancreatic cancer can be resistant to keto, I’m incredibly thankful for this new information on combining a ketogenic diet with an eIF4E inhibitor. It’s so encouraging to see new potential ways to fight this cancer!
I wish you the best on your health journey my brotha, God bless.
Take a combination of ivermectin and fenbendazole
I totally enjoy your mind expanding videos. Thanks Nick!
Ok, Nick, now all you have to do is tell us how to activate the 4E inhibitor, and we can cure pancreatic cancer! Snap! I always watch your posts, and yeah, sometimes you get slightly technical, but you provide way more info and divergent subjects than most of the sites, with the possible exception of Nic on Physionics. The two of you must attend the same comedy workshop, the jokes are worth the price of admission.
You continue to WOW me! Thanks, Nick!!
Too bad I lost trust in medical research. We knew from the 60s about Keto, and food pyramid is still pushed on us. There are entire aisles in Grocery store that should be illegal and there are still advertised as heart healthy. 🤨
What's insane to me is how some companies somehow get away with no nutrition fact label or blatantly false info on their nutrition facts. Like how a zero calorie Gatorade is only zero calories because they defined a serving as ½ a bottle but then the cals per bottle are 5. That math ain't mathing. Makes me now suspicious of everything that claims to be zero calorie.
There’s a loophole in nutrition labeling rules that they can declare 0 calorie if the protein contains 2.5 calories or less per serving.
Sometimes I imagine everyone should be a lawyer so we don’t fall prey to many loophole in law and regulations.
Game changer for my ketosis journey.
So GLAD you brought up the benefits of seeds oils like tahini. Everybody just thinks they are the devil, but as long as they aren't refined, I have no problem with them. I'm starting keto today, so I will be purchasing some tahini to help jump start it, thanks for the hack nick!
While It may greatly increase ketones, it might still be a net negative.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10386285/
@@adim00lah Tahini is sesame paste (unprocessed), NOT sesame oil.
Dr Bikman discussed which fats are best to generate ketones in one of his videos. His position is that body can't store shorter chain fatty acid (8C or under) so they are turned into ketones. According to him this is why MCT oils are so effective for raising ketone levels. Oleic and Linoleic are both C18. How does it work then?
I was going to say just use MCT oil for Ketones
I’ve read widely about and been in ketosis for most of the last twenty years but this is the first I’ve heard about the sesame oil/butter ability to ramp up the ketones. I really enjoy your vlogs; thank you for making all this incredible content.
So interesting< thank you for sharing this value information.
Tahini contains high levels of oxalates, phytates, and some tanins.
Hey, how you include search TH-cam results and link as word in your comment?
First ... poor mouse . I had pet mice as a kid . Second ... your channel is so fascinating. Third ... it's a weird experience to go to the GP and realize they are lagging so far behind in their knowledge of metabolic health .
Great stuff Doc! Thank you!
Very cool. I stumbled onto nuts, simply because I have always been a keto vegetarian and as a keto vegetarian, I needed to get enough calories to cover my 2400kcal BMR and nuts were one of the only plant fat sources with sufficient caloric density to allow me to meet my requirements without overstuffing. I was not aware that the nuts were direcrly contributing to my ability to rapidly switch into ketosis.
Very high in oxalate and phytosterols which disrupt hormones and are highly oxidizable
Not to mention nuts combine carbs fat and protein which actually drives insulin very high not a healthy thing for us
I see Nick post I watch
Ur video about eggs made the newspaper (digital) in my country 😂 they were sceptical, as mainstream media always is
They're never skeptical reading their scripts though 😅
Nick, How does tahini fair against MCT the usual boost into ketosis?
Yesss! I really don't want to eat spoonful's of Tahini...blech!
Artisana coconut butter is really good.
Ironically a lot of keto influencers have demonized Omega-6 fats in recent years just because of a few manufactured oils. Many of the personal trainer gym bros who've only read their study guides and can only parrot back calories also say nuts are bad and probably the best reason to eat a variety of nuts. My TSH is too low and been eating brazil nuts lately for the selenium and i've heard people say to avoid them due to the omega-6 content
omega6s compete with imega3s for consversion/absobtion. Since Omega 3s are beneficial and limiting omega6s can be easier for some people than upping omega 3s, it might not be so wild.
I have heard tho thatit's only ALA that competes since it needs to be converted to EPA or DHA to be "usefull", so this might not apply if your omega3 source is from fish, eggs etc
Its not about omega6, in and of itself. Its about omega 3 to omega 6. If your omega 3 is more than omega 6, and limit omega 6 , youre good.
Had to watch it twice. Again, thank you.
I know you said that LA increases ketones, and then conveniently had a blurp about not bringing up seed oils, but I am curious if there would be any ketone increase if you use seed oils compared to butter or if it would be even worse. Seed oils have high levels of LA. Just a thought experiment I guess because I don't think anyone would try it.
This channel is not for the faint of heart……,really want to understand this guy…..whew…but I love it
What do you mean?
He was pretty clear to me 🤷♂️
@@tedarcher9120 i love this guy,,,,I have a hard time keeping up with him though..,,..I have no education on any of this, so I want to understand it….but it’s hard for me…no complaints here,.he’s great, He knows the science…..it just goes over my head
He is a phd researcher. He uses normal terms for phd researchers. It is worth learning what the words mean.
5:15 How long and stable is the increase? Do polyunsaturated fats get a priority when it comes to fuel because they're less stable when kept around (e.g. polyunsaturated = liquid jet fuel; saturated fat = solid jet fuel)?
Very interesting 😮 I wonder if it's the longer chains of fatty acids that instigates the metabolism to burn more fats. What if one was to try mustard oil, which has VLCFA. It's high in erucic and brassic acid, which have 22 and 24 carbon chains?
Long chain stearic acid upregulates fat metabolism. It's the basis of the so-called Croissant Diet.
Another terrific video!
Dr. Seyfried would argue that the secondary cancer fuel would not be ketones, but glutamate.
(actually, glutamine) and he said he is looking for cancer cells that can use anything else beyond glucose and glutamine for energy, maybe Nick should talk to Dr Seyfried ;)
Exactly
What is a eIF4E inhibitor?
So if I understand this correctly would MCT oil also be a good substitute for the sesame seed oil in raising ketones so much so that it is better than butter as well?? Great content!!
I can't eat most plant material, but if I want to increase ketones fast then I eat MCT or just plain coconut oil. MCT is faster but coconut oil is just as reliable and last a little longer.
Goat butter has higher levels of MCTs. I use cultured goat butter from Mt. Capra. The culturing breaks down the fat molecules and makes them more quickly bioavailable. So, goat butter should be one of the most ketone-boosting sources of fats around.
Also, consider that monogastric animals will store whatever fats they eat. If pigs and chickens are fed linoleic acid and MCTs, that is what fat will be available in the foods procured from them: meat, eggs, lard, etc. But such foods would be hard to find on the mainstream market.
I only heard him talk about LA being more ketogenic than butter, and hinted that unsaturated fats would be more ketogenic that saturated.
Since MCT oil is virtually all saturated, why do you think MCT would be more ketogenic?
MCT have to be burned so definitely very ketogenic they can't be stored
@@mlaroche2009 - We know from old and well established research that MCTs are easily and rapidly converted into ketones in the liver. It's been a common practice to use MCTs in the medical application of the keto diet to treat disease.
What inhibits it ???
Down the road from us is a farmer-nutritionist who has a laboratory right on his farm. He swears by a daily regimen of butter, eggs and tahini because it contains the much overlooked EIEIO inhibitor. His name is MacDonald.
oooooooooooowwwwwww ! LOL!!
Have you tried your hack to raise your ketone levels using olive oil rather than nut butters considering olive oil has a substantial amount of linoleic acid?
I do OMAD so if I eat 3 tbsp of tahini with my meal I should lose more fat?
What about metformin? Whats it's effect on AMPK?
Compared to butter and tahini, how would coconut oil or macadamia nuts stimulate or inhibit ketosis? I’ve heard many times that coconut oil is related to MCT oil, which is good for stimulating ketosis.
What about clean alcohol whisky or vodka, can they promote high ketones. More likely acetone??acetate??
since my wife hates alcohol I might try this n=1 experiment
hahaha idk if using alcohol would be the best way to up ketones
These videos are so much better when the springbok on the rugby ball is clearly visible, like in this one
Does this fatty acid signaling explain why sardine “fasts” seem to lower glucose and bump ketones even without significant caloric restriction?
What other food sources of fat could provide similar effect??
MCT
So what do u have to eat/take to activate that inhibitor to kill pancreatic cancer?
I have it in my head that melanoma also thrives despite a ketogenic diet - is that correct?
When you ketones are mega high at 5 or 6 (which is incredible), what level is your blood glucose?
AWESOME INFO thank you!!!
SO tahini isnt better than sunflower unprocessed oil? Its just seeds oils that make the hack work? Wasnt really clear from the video. I can choose for example olive oil??
Can fasted exercise of an appropriate level and duration also boost ketone levels, to the sky high ones you got?
So now speculate what happens if glucose levels are high and EIF4E is being excessively activated.
The nut butter portion is going to be taken out of context :/
How can we get eIF4E inhibitor naturally?
Sesame oil are often sold mix with other oil. Why? because its expensive and difficult to extract oil from them. You can find REAL 100% pure sesame oil but its really expensive. Yes more expensive than virgin olive oil and very short expiry date.
What about the claims that linoleic acid is bad for us?... That it causes heart disease etc. I'm talking about unprocessed unrefined unoxidized linoleic acid of course.
Nobody knows if this "hack" is healthy.
It's an essential fatty acid.
If I understand correctly, the ideal ratio omega3 to omega6 is one, so if you eat a table spoon of sesame seed oil, take a spoon of fish oil (roughly, depends of course on the omega6 content of sesame seed oil and omega 3 content of your fish oil). Would be interesting for Nick to see if he still reaches his high level of ketones this way...
i've heard the same but the data is really sketchy and probably relies on a few manufactured seed oils and not on the variety of natural omega-6 sources out there
Omega-6s easily oxidize, both on the shelf and in the body. This increases oxidative damage, inflammation, and mutagenesis. Something can be healthy in one way and potentially unhealthy in another.
Also, it's a matter of degree. Using linoleic acid in small amounts or occasionally is far different than consuming it in large amounts every day. You could try to balance omega-6s with omega-3s, except omega-3s also oxidize easily.
It's possible that, instead of omega-3s, you might be able to consume linoleic acid with C15 that has many of the same benefits as omega-3s and may be even more beneficial. But I don't know of any research on how linoleic acid and C15 interact.
I don't know if linoleic has any advantage over MCTs. After all, MCTs have all the benefits and none of the downsides of linoleic acid. Plus, one can get higher levels of MCTs from a variety of sources, including goat butter and ghee.
Plus, if it's cultured goat ghee, it has smaller fat molecules that are more bioavailable. It's possible this would be even more beneficial right before a fast. I get my cultured goat ghee from Mt. Capra.
Very interesting
People you dont need meat. I eat vegan keto combined with a lot of bryan johnson. Really good healthmarkers and even delicious eating. You really really dont need it. Just some skills, cooking, using a freezer etc..
Pushing extreme ketone levels is not really necessary or good
In ancient Greece, athletes ate meat, cheese, and barley to build bodies strong enough to wrestle lions-now we’re wrestling snack cravings and wondering why we’re weak. If the Greeks could fuel empires on real food, what in the world makes us think a diet of processed junk will Make America Healthy Again? Sometimes the wisest move is the simplest-eat like the ancients, not like a vending machine.
Isn't that too much of LA to consume?
It might not be healthy long term. Certainly not something we did long term in our evolution
Linoleic acid, like all PUFAs (omega-6s and omega-3s), are easily oxidized both in processing and in the body. This means they cause oxidative damage, inflammation, and mutagenesis. One would be advised to not consume them excessively and regularly.
But they might be fine to promote ketosis on occasion. Then again, MCTs will promote ketosis without any of the oxidative problems. One can get more MCTs from coconut oil or goat butter and ghee. I'm not sure linoleic acid has any advantages, in this case.
Keto king !
Never had tahini before
If you’ve had hummus, you’ve had it. It gives the somewhat “nutty” flavor in hummus. It’s just ground up roasted sesame seeds. I think it’s delicious, of course, taste is a very subjective thing.
@@RickinICT oh okay so I have had it. Just not straight tahini. I am gonna give it a try
Our genome only encodes for 20-25k proteins. With splice variants that may be taken up to 80-100k but I'm not sure if it's actually over 100k different proteins.
First! Stay curious!
is Norwitz a Polish or Jewish name?