@@AnthonyLee-dj1xo I think he mentioned that it was the much maligned linoleic acid. If that's the case, any cold pressed, refrigerated source will do as will any fresh, raw nuts and seeds.
@@nicknorwitzPhD- Hello Dr NickNorwitz, As you know social media is flooded with the claim it's the small oxidized LDL particles that are harmful and the cause of arteriosclerosis, not the bigger LDL particles. There are a couple of youtubers that have covered this but none as seriuos and trustworthy as you are. (flattery) 🙂 For instance Dr Sten Ekberg did a video showing the change in one of his patients particle counts. On a ketogenic lowcarb-diet his patient's small oxidized LDL particles decrease compared with the same patient's particle count before the LCHF-diet. Wouldn't it be interesting for your audience to see you conducting a small study on this topic. Even if it's just a few participants it could be quite telling. Or as usual conducting an anecdotal test on yourself. Does the oxidized small LDL particles decrease on a ketogenic lowcarb-diet? Dr Sten Ekberg's video; Your doctor is wrong about cholesterol: (Oxidized LDL particles, About 19 minutes in) th-cam.com/video/sY48qLl9ZzE/w-d-xo.htmlsi=rVBTAK9xAuGFx5Lz Best regards Acke, Sweden - stayin' curious !
Thank you so much for this video! I had pancreatitis a few years ago and may have chronic pancreatitis now. My mother passed away from pancreatic cancer last year, so this topic hits close to home. I’m currently on a keto diet, and while it’s frustrating to know that pancreatic cancer can be resistant to keto, I’m incredibly thankful for this new information on combining a ketogenic diet with an eIF4E inhibitor. It’s so encouraging to see new potential ways to fight this cancer!
Sorry you have pancreatitis too! I am also on keto and IF (to prevent sibo). Did carnivore for a while. Felt great but was worried it would burden my pancreas too much. My pancreas is severely damaged and supplementing pancreatic enzymes made me sicker i.s.o better. No support from doctors here, so on my own to figure out how to best manage my symptoms. Keto and fasting are very far from the protocol in Holland. Interested to know why you chose to do keto and how it's helping you.
I wonder if Thomas Seyfried's research on cancer as a metabolic disease might give you additional help. His metabolic therapy is outlined in his book. It's a strict therapeutic type of keto. Aside from that there's also what others have mentioned: ivermectin, fenben (and the human version, menbendazole). Hope this comment doesn't get deleted!
I tried 2 tbsp sesame last night and I'm in very mild ketosis (.6 mmol/L) today even though I haven't been eating a ketogenic diet the past 4 weeks while I was on vacation. Can't wait to try this when I am actually eating a keto diet again!
I bought some tahini because of this video and find that it is almost intolerably bitter. Is this how it should taste or is there something wrong with this product? I bought the exact brand that Nick shows in this video. Maybe it is an acquired taste.
Nick your channel is the best, I love the fact you report on real studies and present in way us meer mortals can understand, I have severe (anaphylaxis) egg and nut allergies all my life, which are counter productive on Keto, but I am good for sesame seeds, so I'm going to give Tahini a go... Thank you so much for your posts, I'm learning everyday... I also beat stage 4 colon cancer on Keto with fasting, without any chemotherapy, but I did have the tumor remains removed in 2021... I was given a 40% chance of surviving 2 years... Today I am cancer free...
Rectal cancer here. main tumor still present. i refused TME bc, well, bc it would have been stupid. lucky yrs was removable. i would have had a permanent colostomy, and most ppl i know with low rectal tumors wind up dying anyway despite SOC "care" bc of local recurrence or mets so i'm v. happy 4 u. xoxo and u give hope to many.
I’ve read widely about and been in ketosis for most of the last twenty years but this is the first I’ve heard about the sesame oil/butter ability to ramp up the ketones. I really enjoy your vlogs; thank you for making all this incredible content.
Too bad I lost trust in medical research. We knew from the 60s about Keto, and food pyramid is still pushed on us. There are entire aisles in Grocery store that should be illegal and there are still advertised as heart healthy. 🤨
What's insane to me is how some companies somehow get away with no nutrition fact label or blatantly false info on their nutrition facts. Like how a zero calorie Gatorade is only zero calories because they defined a serving as ½ a bottle but then the cals per bottle are 5. That math ain't mathing. Makes me now suspicious of everything that claims to be zero calorie.
There’s a loophole in nutrition labeling rules that they can declare 0 calorie if the product contains 2.5 calories or less per serving. Sometimes I imagine everyone should be a lawyer so we don’t fall prey to many loophole in law and regulations.
The majority of sick people don't follow the food pyramid. Yet everyone is blaming the foods people don't eat. How come a few decades ago, vegetables, fruits, tubers, some grains, dairy and meat were fine. Unfortunately, we like convenience and that comes at price. I wish people used a little of common sense and stop this nonsense that keto or carnivore is some sort of holy grail of nutrition when it's clearly not. That's not to say it can't work as an intervention.. I believe sticking to such a diet makes it easier to avoid processed foods
I have been waiting years to hear someone even mention that some cancers can thrive on a fatty acid fuel source. Fascinating stuff! Thank you once again.
I dont there are any studies that show this - this is an assumption .. I would be very interested in seeing any studies showing any cancer can use ketones for fuels
@@geoffreylevens9045Just to put a finer point on this, I’d like to see a study showing fatty acids used as a fuel. My understanding, per Thomas Seyfreid, is that glucose and glutamine can be used as fuels. My question is what other molecules act similarly. Thanks!
Interesting mice study at the end. When I had cancer (Melanoma) and get it worse to stage 4 I was scheduled to start immunotherapy treatment. I began going very hard keto (25g carb, high fat - low protein ratio, taking exogenous ketones in morning to ramp up it up) just as my treatment started. I can't say with any kind of proof but I'll always be convinced that timing them together like that worked in my advantage so that it provided an extra shock to the cancer cells (starvation via keto, immune enhancement via treatment) before they had time to adapt which allowed my body to get rid of the cancer.
Ok, Nick, now all you have to do is tell us how to activate the 4E inhibitor, and we can cure pancreatic cancer! Snap! I always watch your posts, and yeah, sometimes you get slightly technical, but you provide way more info and divergent subjects than most of the sites, with the possible exception of Nic on Physionics. The two of you must attend the same comedy workshop, the jokes are worth the price of admission.
Thought I was fit and healthy to begin with.. surely everyone is tired after breakfast and lunch, has headaches and uses the bathroom three times a day right? Went no/very low carb (less than 25g per day) out of curiosity and boy oh boy did I have no clue, what GOOD felt like. Limitless energy, bodyfat went from 10.5 to 6.5 with zero muscle loss, laser focus, mental calmness - cuts heal in record time, my testosterone is through the roof.. that feeling you get when a cold is knocking on your door? Gone the next day. And I'm just in low to mild GKI ketosis (0.5 to 1.5 mmol/L) I will never ever go back to eating carbohydrates, knowing how that misery is not NORMAL.
I had a similar experience. Went keto for a year and felt fantastic. While I still primarily follow a keto diet, I’ve introduced some carbohydrates into my meals. This is because consuming too few carbs can, paradoxically, lead to insulin resistance caused by persistent excessive glucose production from constantly elevated glucagon levels. To prevent this, I now ensure that I consume some carbohydrates with each meal so as to limit the need for glucagon release to support normal blood glucose levels.
@@mjoh090 I am unaware of any study showing it leads to IR. It can lead to adaptive glucose sparing, so morning glucose can float up as you don't need it any more. But a proper OGTT or OGTT with insulin will likely show you are still insulin sensitive on keto. Even a simple postprandial glucose test will probably be enough to show you at home you are just fine. The "physiological insulin resistance" that some people talk about is during pregnancy. check InsulinIQ Channel by Dr. Bikman,
Isn't borage oil or primrose oil a better source of linoleic acid, than sesame seed? And are you sure this enhances your ketone levels more than MCT oil, or simply coconut oil (which contains MCT-oil and isn't so tough on the stomach like pure MCT-oil)?
Nick, my nephew has pancreatic cancer. PLEASE tell us more about the inhibitors. How/where can we get them and combine them with the ketogenic diet? Please.
'Can a keto diet eliminate cancer growth? Dr. Thomas Seyfried says yes' 'The press pulse strategy' part under this video. Just happened to listen and then saw your comment. Hope not out of context, I'm new to keto.
Funny how 99% of our food is processed. Anything the FDA says to eat I just do the opposite. I recommend reading “Health and Beauty Mastery” by Julian Bannet, that book is a real eye opener about shocking stuff health industry is doing! I completely changed my habits
I don't know what the book says, but you do realise that the "big pharma doesn't want you to know this" shtick is schoolbook sales talk to fool you into thinking they have some special secret? Be careful not to be fooled by snake oil salesmen, in your process of trying not to be fooled by big pharma
What I appreciate most about you is your intellectual conscientiousness. Often, I observe most “science-based” media hastily refer to studies to justify advice or health claims, without any further discussion of the results, hypothetical or theoretical mechanisms. Rather, you offer a deeper and broader scientific perspective that- I think- provides a relatively much greater net good to the consumption of media.
Dr Bikman discussed which fats are best to generate ketones in one of his videos. His position is that body can't store shorter chain fatty acid (8C or under) so they are turned into ketones. According to him this is why MCT oils are so effective for raising ketone levels. Oleic and Linoleic are both C18. How does it work then?
@@doddgarger6806 For many of us, MCT oil has adverse GI effects, even at low doses and after habituation. Sesame seed butter (tahini) has a better GI and taste profile though it has some carbs (and protein as well). I'll try it. :-)
MCTs have a different metabolism whereby they go via the portal vein to the liver and also don't need a shuttle system to get into mito so they burn faster... the 'sesame effect' is more delayed, but I find gets to higher levels. I know Ben well. Good guy. Good friend.
Preferred vs prioritized question: Does linoleic acid have negative effects past the body's need? It makes sense that the body would prioritize conversion to ketones once need is supassed so that remaining form is benign. I would like to hear what happens when 1) The omega 6 to omega 3 ratio is maintained but the percentage of calories is increased. 2) Just the omega 6 only is increased (like the video) past bodily needs 3) Just the omega 3 only is increased past the bodily needs 4) Long term effect on inflammation and cellular lipid profiles. Would this show that the body readily handles the polyunsaturated fats that are not needed for biological functions into the ketone form as suggested in video. Then what does this mean -- does prioritized ketone generation in context of polyunsaturated fat mean preferred calorie source or prioritized for cinversion/disposal? As a parallel, doesn't alcohol get converted to ketones by conversion to acetate while simultaniuosly blocking glucose metabolism rasing ketosis allowing for prioritized alcohol disposal through ketogenesis and utilization?
Nick, Great video. I'm on week three of a sardine fast. I eat three cans around 3 pm every day. I also take three tablespoons of MCT oil daily. My ketones run between 4 and 6.5. This program is extremely easy to maintain. My question to you is ... what is it about sardines that jack my ketones so nicely? It's better that a 72 hour water only fats for me.
First ... poor mouse . I had pet mice as a kid . Second ... your channel is so fascinating. Third ... it's a weird experience to go to the GP and realize they are lagging so far behind in their knowledge of metabolic health .
Doctors are taught how to keep you alive in the hospital. We are not taught how to turn your body into a high performance machine. That's as far as our metabolic knowledge goes and yes, it is good enough to save your life.
Hi Doc, you are my most trusted Doctor on the internet, I like most of your content, just want to ask you something, from whole food to keto, how do I do it safely? I am 65 year old man.
Thanks for the kind words. That's a very broad question. I think if you tend to eat a whole foods diets, low in sugar and processed foods and with sufficient protein, you're a good deal of the way there. If you want support, maybe a dietitian specializing in ketogenic diets, or a community group filled with people with experience who might be able to offer tips. Without knowing your medical background, I can't give more specifics. Sorry. Even were I to know your history, a TH-cam comment isn't the place to give personal advice.
I hope you get to research a whole bunch of keto for beginners videos. You'll get a feel for the most common transition problems. Usually those have to do with avoiding the keto flu with the help of electrolytes. On top of finding individualized help, I would suggest taking a look at the beginning tips and methods from Dr. Annette Bosworth (Dr. Boz, she has a good workbook you can add to your library, "Keto Continuum"), Dr. Eric Westman and Dr. Ken D Berry just for starters. Dr. Tim Noakes recently put out a comprehensive book, "Ketogenic", which might be super helpful as well. Transitioning might take around 3 weeks, and then fully fat adapting might take at least 3 more months. Dr. Stephen Phinney and Jeff Volek did a lot of foundational research on keto. They have books as well as vids on it. Good luck!
Dear Dr Nick! Thanks for this. FYI: 4 T tahini has 12 g carbs. Yikes! Plus, diners must prepare tahini to eat it to avoid solvent flip and choking problem. Simple 2 serving recipe: weigh into cereal size bowl 120 g Tahini, 60 g water, 1/8 t Redmans pink salt, 1/4 t garlic powder, 1 t vinegar, and mix with wisk. Please add to notes. ❤❤❤ I’m thrilled to try adding tahini to boost my ketones. You’re awesome, Dr Nick!!
6 grams net carbs actually per 1/4 Cup (Tbsp)... that's ~ 6% kCal from carbs... sounds keto to me. I don't think Tahini is a choking hazard. Thanks for the recipe suggestion.
When my husband was battling pancreatic cancer I was reading every research I could find on its pathways. None of them mentioned ketones.😢 In fact his tumor initially shrunk, not sure if it was due to Folfirinox or the fasting he did during chemo.
I was little confused on pancreatic cancer issue. Guess I’ll need to listen again. Have a friend with pancreatic cancer and just trying to learn as much as I can.
How relevant are the levels of ketosis? Anything that allows one to reach 5 rapidly evokes suspicion. Moderate levels long distance seems comfortable. Not to dismiss the peculiarity of the tahini effect. It would be interesting to see further studies in this direction. Watching Dr Seyfried’s numerous videos not ones have I come across his mentioning of the pancreatic cancer’s ability to use ketones for fuel. He specifically emphasizes that ketones are never used as fuel for any cancer. Perhaps something went amiss. Most likely on my part.
I have heard Dr Seyfried qualify this by saying that cancer cells cannot use other fuel sources besides glucose and glutamine for a meaningful length of time. They may use it for fuel in a very short term situation but cannot survive on other sources in the long run. Perhaps that is the confusion.
@@Margaret2494 yes. He says glucose and glutamine used by cancers for fermentation. Listened to his videos again today, specifically stated that all cancer cells follow the same pattern and there was no cancer that uses a different pathway.
So GLAD you brought up the benefits of seeds oils like tahini. Everybody just thinks they are the devil, but as long as they aren't refined, I have no problem with them. I'm starting keto today, so I will be purchasing some tahini to help jump start it, thanks for the hack nick! Edit: I just bought a bottle of organic unrefinied untoasted sesame seee oil
That insight about getting ketones higher using LA could improve the lives of many suffering with chronic disease symptoms, kudos to you Nick, well done ✨👌
@@ellieb2914 tahini tastes great, when combined with corn syrup, eggplant 🍆 purée, or chickpeas. However, I don’t want to eat syrup again, and I don’t want to consume hummus or baba ghanoush frequently.
Interesting that something like tahini pushes your Ketones higher quickly. Considering it’s not a readily available foodstuff in nature you have to wonder if having high ketones is such a great idea? If most people take a week of fasting ( starvation more or less) to achieve the same then it’s not really something a hunter gatherer would try and do the aim being to find food and therefore not get into deep ketosis.
I'm not sure hunter-gatherers had ANY intentions with respect to ketones. The reality of their life was that there might have been long gaps between feasts. Also sesame had limited distribution in nature (India and sub-Saharan Africa) before it was domesticated about 3,500 years ago, too soon for me to include it in the 'what were evolved to ' list
Amazing stuff NIck! As a scientists, I can barely dig through the countless studies but you seem to have a nack for finding these gems. Keep spreading the science!
I agree on the linoleic acid! I disagree on the keto safety, he cherry picks studies like crazy and most of the studies he cites are 2 week durations the most.
Hi Nick, thank you for bringing this study to our attention. Given the results, would you advise a ketogenic diet for people with pancreatic damage / fibrosis due to acute or chronic pancreatitis? Would keto enhance the risk of developing pancreatic cancer?
I don't think anything I said in this video generalizes to pancreatitis. And no, I see no reason to think ketosis would increase the risk of developing pancreatic cancer.
@@nicknorwitzPhD Thank you Nick, no you didn't, I was just wondering. Damage from pancreatitis enhances the risk of developing pancreatic cancer. A constant worry. I wondered if being in ketosis could increase that risk.
I have two questions first you are already on a ketogenic diet and you do this 4 spoons of tahini? the second one what's your keys are ketone level after 16 hours of fasting?
Dude, youre the man! Such awesome knowledge you impart to us all. Super appreciate your energy and desire to help us all out by learning more about our awesome bodies! Yew!
5:15 How long and stable is the increase? Do polyunsaturated fats get a priority when it comes to fuel because they're less stable when kept around (e.g. polyunsaturated = liquid jet fuel; saturated fat = solid jet fuel)?
question - How does eating an external fat like sesame oil, translate into the burning or utilization of stored body fat which is why most people start a keto diet in the first place.
Very interesting 😮 I wonder if it's the longer chains of fatty acids that instigates the metabolism to burn more fats. What if one was to try mustard oil, which has VLCFA. It's high in erucic and brassic acid, which have 22 and 24 carbon chains?
Congratulations on 100K subscribers, Nick! Well deserved! You make excellent content and your self experiments are so informative and revealing. Oreas and eggs…. Oh my!
@@nicknorwitzPhD The study comes to conclusions most of us watching are prepared to accept due to our biases. But, you entirely gloss over it. Since you have access to its entirety and are making a video about it, it would be more helpful to provide insight from behind the paywall. The proximal origins of that thing was also published in nature. Along with lots of redacted articles. Serious question, why do you feel this study is accurate?
Hi Nick. Your work and content is very impressive and thought provoking. Keep up the great work. Question. Curious about your thoughts on LDL fractionation data. I've been low carb and health focused now for about 4 years. Biomarkers are improving. I'm 60 so not a kid. I have CVD and atherosclerosis. I started doing much more red meat and even lowered my statin about 3 months ago. My LDL Particle number went up significantly and so did my small dense LDL value. Seems counterintuitive. Curious if you have any thoughts on the subject and if you feel that those are valuable biomarkers. Dr. Brewer really focuses only on Large HDL. Keep up that great work.
Nick, how long does it take to fully be keto adapted. I am on week 3 of keto , and even though I am getting enough fat, protein, and electrolytes, I still feel pretty tired and weaker. Any thoughts? Also, how in the world are you so strong and can do 230 pushups at 14 years old? Or are you just a special case, or can anyone work toward something like that?
5:24 Wait, linoleic acid ? That's an omega-6 right ? Isn't that pro-inflammatory ? Could the same be achieved with omega-3 fatty acids ( given that it was a bout unsaturated fats) ?
Great video, Nick. It’s a pity a lot of the comments take the information you present out of context, but glad you share the information that you do and hope you continue to do so.
He didn’t mention how to lower elf4e so I’ll jump in here for him. Capsaicin affects eIF4E activity indirectly through its impact on the PI3K/Akt/mTOR pathway. Capsaicin can inhibit Akt phosphorylation, which in turn affects mTOR activity. mTOR increases eIF4E activity by inhibiting 4E-binding proteins (4E-BPs), thereby promoting cap-dependent translation. Therefore, capsaicin may reduce eIF4E activity by modulating this pathway, potentially influencing processes like autophagy and apoptosis in cancer cells.
Seems like a good point worthy of a response. Nick, is it that the benefits outweigh the costs mentioned by previous commentor, or are the objections somehow invalid?
@@walterwilkinson1499 its not a perfect diet world... simple. Pay your money and take your chances. Most of the middle east lives off tahini and way back into the mists of time
So if I understand this correctly would MCT oil also be a good substitute for the sesame seed oil in raising ketones so much so that it is better than butter as well?? Great content!!
I can't eat most plant material, but if I want to increase ketones fast then I eat MCT or just plain coconut oil. MCT is faster but coconut oil is just as reliable and last a little longer.
Goat butter has higher levels of MCTs. I use cultured goat butter from Mt. Capra. The culturing breaks down the fat molecules and makes them more quickly bioavailable. So, goat butter should be one of the most ketone-boosting sources of fats around. Also, consider that monogastric animals will store whatever fats they eat. If pigs and chickens are fed linoleic acid and MCTs, that is what fat will be available in the foods procured from them: meat, eggs, lard, etc. But such foods would be hard to find on the mainstream market.
I only heard him talk about LA being more ketogenic than butter, and hinted that unsaturated fats would be more ketogenic that saturated. Since MCT oil is virtually all saturated, why do you think MCT would be more ketogenic?
@@mlaroche2009 - We know from old and well established research that MCTs are easily and rapidly converted into ketones in the liver. It's been a common practice to use MCTs in the medical application of the keto diet to treat disease. But it's also a widely known keto hack among keto advocates and in the keto community. Many stores that sell keto products will sell MCT oil in the same section. You can find thousands of research papers, popular articles, and TH-cam videos about ketosis and MCTs. Also, I've looked at numerous books that discuss ketosis and keto diets, and they typically will mention MCTs.
Spoiler alert .. @4:38 - Hack re: ketogenic fat sources. So, basically the sesame oil with the linoleic acid acts as a singalling molecule. So how can I best employ this? Take a dose of sesame oil, and then fast for 24 hours? We should be able to test this ourselves (Is it still 'N of one' then?). Please add any further details, tips, or testimonials if you have them!
How many carbs does tahini have in and I'm wondering what if there's authentic keto friendly healthy tahini verses cheap Walmart tahini. I know ghee can be made very badly form vegetables and seed oils. Do you know anything about different products. And lastly did you do the experiments with the cookies. Did it raise your ketones? I've been back on meat heavy keto for a few weeks and haven't got my energy back or lost weight. Thanks for the recipe. I may try it either way but was curious.
Linoleic acid (Omega 6) really(?) What about the balance with Omega 3? Is it that in a deficit it is only burned without being stored and damaged? How does that affect fat loss?
Fascinating - Due comments here about fasting and ketosis, would appreciate Dr. Norwitz's analyses (or of any reader in the comments) of the "5/2 diet" .....eat normally five days, fast two. The two "fast" days are not true fasts, and are not consecutive days - ...merely under 600 calories for men, 500 for women. My unscientific sample size of one results - From 194 pounds to 165, over five months - College weight and tone. High school isn't a good compassion. As I entered college at 17, I was still growing until about age 19 or so. ..and didn't really need to shave until my early 20s. TMI? :)
FMD fast mimicking diet Because Longo doesn’t understand fasting is NOT starving Either eat Or fast Starving is a stress on the body Fasting triggers all sorts of positive response
@@YeshuaKingMessiah While I'm grateful for the good works, accountability, and morals that Christianity teaches ...Jesus was a false Messiah, per the very Bible in Christians profess knowledge. The Bible is clear, when the Messiah comes: 1 - He will not be divine 2 - The entire world will worship God, and know he is the only true God 3 - There will be no more war These prophets, in which Christians claim 100% validity, state that we can recognize the Messiah when all of the following take place during the Messianic Age: Ezekiel Building of the final Temple that will stand forever in Jerusalem Deuteronomy 30:1-5 Return of the lost tribes to Israel Daniel 12:2 Resurrection of the dead Isaiah 11:9, 10 Knowledge of God throughout the world, and obedience to God Isaiah 2:4 Nation shall not lift up sword against nation, neither shall they learn war any more. None of the above happened 2000 years ago/ Jesus fulfilled no prophecies Result? Church leaders after the year 100 invented ..."Jesus, The Return" aka The Second Coming. Then in 325, the Church invented the Trinity at the Council of Nicaea. Yet the Bible explicitly states that God will never be split into parts, and only God is to be worshiped. Sorry, you're been misled. Not your fault. Ex - Church claims that Isaiah 53 is about Jesus have been endlessly debunked. This has been a classic tactic of Missionaries. Good hearted and sincere for sure, but deceived. Almost always by Pastors, who in turn have been deceived. The Servant noted in Isaiah is the Nation of Israel, not the Messiah or Jesus. Isaiah 43-10 "You are my witnesses {plural}, declared the Lord, whom I have chosen" Isaiah 43:11 "I am the Lord. Besides me, there is no other" Why do you think these verses aren't taught to Missionaries, or spoken of in any Sunday Church service? Be honest. Because these are yet another proofs that - 1 - The "Servant" is the Nation of Israel, and that the Jewish people of today worldwide are Servants, not Jesus. As all Jews are members of the Jewish Nation, regardless of passport. 2 - The Trinity's invention in the year 325 has no foundation in the Bible. In fact, it's directly opposed by the Bible. Clear to anyone who reads the entire book, rather then cherry pick select passages out of context. What does it say in Isaiah 52 and 54? Why is only 53 taught to Missionaries, and accented, but others ignored? Per the Hebrew Bible, again in which every Christian denomination claims is 100% valid....when the Messiah finally does appear- Zechariah 8:23 holds - “This is what the LORD of Heaven’s Armies says: In those days ten men from different nations and languages of the world ... will clutch at the sleeve of one Jew. And they will say, ‘Please let us walk with you, for we have heard that God is with you.’”
@@tedarcher9120 i love this guy,,,,I have a hard time keeping up with him though..,,..I have no education on any of this, so I want to understand it….but it’s hard for me…no complaints here,.he’s great, He knows the science…..it just goes over my head
WOW! This is huge on pancreatic cancer cells!! Love this but still many questions on the Omega 6 FA considering the need for balance of Omega 6s/Omega 3s, also the high levels of ketones, also other side effects of seed oils considering the problems with many of them being rancid.
(actually, glutamine) and he said he is looking for cancer cells that can use anything else beyond glucose and glutamine for energy, maybe Nick should talk to Dr Seyfried ;)
@@doddgarger6806 That caught my eye as well. According to Seyfried, cancer cells can't metabolize ketones, because that can only be done with working oxidative phosphorylation, which cancer cells have lost due to extensive mitochondrial dysfunction, and which is precisely the reason why they had to upregulate fermentation and become cancerous in the first place, using glucose and glutamine as the substrate.
Seyfried hypothesises that the reason these studies see higher cancer cell ketone "uptake" in a ketogenic state is because ketosis promotes mitochondrial uncoupling, resulting in more mitochondria and more consumption.The fault with these studies as he puts it, is that they automatically conclude the cancer cells are sufficiently producing enough energy from the ketones to survive, when what they should be doing instead is measuring energy production, while simultaneously removing the alternative fuel glutamine. His team has tested this for all major cancer cell lines, including pancreatic cancer.
Very cool. I stumbled onto nuts, simply because I have always been a keto vegetarian and as a keto vegetarian, I needed to get enough calories to cover my 2400kcal BMR and nuts were one of the only plant fat sources with sufficient caloric density to allow me to meet my requirements without overstuffing. I was not aware that the nuts were directly contributing to my ability to rapidly switch into ketosis.
Very high in oxalate and phytosterols which disrupt hormones and are highly oxidizable Not to mention nuts combine carbs fat and protein which actually drives insulin very high not a healthy thing for us
I also really enjoyed deluxe mixed nuts on keto up to the point I ended up in the ER with a kidney stone of the most common calcium oxalate variety. No more nuts for me after that as nuts are very high in oxalate. I learned my lesson, no more nuts for me. Straight carnivore ever since.
@@petertownsend252 I have been vegetarian for 5 years. Never any stones. Note that I am vegetarian and eat dairy, which provides the calcium to bind the oxalates, which is why I have never had any stones. I also have an ample supply of k2 to then take excess calcium into bone and away from arteries. I have zero arterial calcium. Btw all nuts and seed I eat are raw. I consume about 100g of a mixture Pecans, Walnuts, Brazil nuts, Macadamia nuts, pine nuts, sunflower and pumpkin seeds. Based on the information in Nicks video I will add sesame seeds.
@@geode232 Because roasted nuts have advanced glycation end-products. AGEs occur at high temperature. I never eat foods that aren't raw, boiled or steamed (where the heat can't be much above 100 degrees C).
Did you rule out if the lower count was reflecting the body’s adaptation to using fat stores efficiently for energy as in butter being more bio available and readily absorbed by the body as compared to a fat source from a seed?
@@nicknorwitzPhD, I don't think I've ever heard you saying you eat any vegetable... Have you thought of trying to experiment this with a keto person using avocado?
Am sooo glad u r addressing the difference in fats. btw, in me protein leads to higher BG presumably bc of gluconeogenesis. Stage IV rectal cancer here. DId NOT do all SOC "therapy," ergo am still thriving, but that which I agreed to led to ill LT fx. I wish I could do meat-based keto, but my GI luvvvs high fiber. Raw is best 4 me. A raw beet or carrot does NOT raise BG by even 1 pt. Cooked veggies do. But too much arginine in nuts (sob sob). Will try tahini but will also be wary of amino acid content bc of tumor ability to make glutamate from many amino acids.
Good info, but what a mouthful of jargon! I'll have to listen to this again tomorrow, maybe it'll penetrate my thick skull. I am attempting a fast - drop insulin & glucose & triglycerides, etc. Question - does ketosis trigger autophagy (no protein, and protein is a builder)? Or does autophagy need total fasting (because ketones are an energy source). The reason for my question is - if autophagy is not affected by ketones, then eating some fat will help reduce hunger pangs.
GL... the sesame oil might work a tad better if you're optimizing for BHB... have with very low carb dinner and then fast overnight and for ~20 hours... see what happens.
WHy is BHB that high good? Some influencers think that that's keto acidosis and is dangerous. If I feel great on carnivore, do I need to chase that? Also, what about processed nut butters and seed butters being oxidized and rancid - and pro-inflammatory? I realize they're not industrial seed oils (which give me migraines), but I am worried about them. What about oxalates in these nuts/seeds? And other plant toxins?
One of the genetic variants I look at are those in the FADS genes, relating to liver phosphatidyl choline and the inflammatory potential (or not) of linoleic acid. Tend to find that folks with high linoleic acid (on an omega 3/6 panel) often have low arachidonic acid (too low) and highish inflammation. Those people I caution against relying on high linoleic nuts (I thought macadamia nuts were low in LA??!!) to reduce inflammation. Long intro to question: have you looked at any side effects of inflammation in these tweaks?
I looove this fast-paced uber-geeky presentation. only left hanging on how to obtain the (ED4 whatever) inhibitor that slows pancreatic cancer in the presence of a ketogenic diet...just in case I or anyone in my circle should happen to get diagnosed. signed, old lady walking encyclopedia-type always wanting to help 😁
You continue to WOW me! Thanks, Nick!!
Thank you Cynthia!
@@nicknorwitzPhD Does it have to be tahini, or can you use sesame oil as well?
I too am World of Warcrafted by the video.
@@AnthonyLee-dj1xo I think he mentioned that it was the much maligned linoleic acid. If that's the case, any cold pressed, refrigerated source will do as will any fresh, raw nuts and seeds.
@@nicknorwitzPhD-
Hello Dr NickNorwitz,
As you know social media is flooded with the claim it's the small oxidized LDL particles that are harmful and the cause of arteriosclerosis, not the bigger LDL particles.
There are a couple of youtubers that have covered this but none as seriuos and trustworthy as you are. (flattery) 🙂
For instance Dr Sten Ekberg did a video showing the change in one of his patients particle counts.
On a ketogenic lowcarb-diet his patient's small oxidized LDL particles decrease compared with the same patient's particle count before the LCHF-diet.
Wouldn't it be interesting for your audience to see you conducting a small study on this topic. Even if it's just a few participants it could be quite telling. Or as usual conducting an anecdotal test on yourself.
Does the oxidized small LDL particles decrease on a ketogenic lowcarb-diet?
Dr Sten Ekberg's video;
Your doctor is wrong about cholesterol:
(Oxidized LDL particles, About 19 minutes in)
th-cam.com/video/sY48qLl9ZzE/w-d-xo.htmlsi=rVBTAK9xAuGFx5Lz
Best regards
Acke, Sweden - stayin' curious !
Thank you so much for this video! I had pancreatitis a few years ago and may have chronic pancreatitis now. My mother passed away from pancreatic cancer last year, so this topic hits close to home. I’m currently on a keto diet, and while it’s frustrating to know that pancreatic cancer can be resistant to keto, I’m incredibly thankful for this new information on combining a ketogenic diet with an eIF4E inhibitor. It’s so encouraging to see new potential ways to fight this cancer!
I wish you the best on your health journey my brotha, God bless.
Take a combination of ivermectin and fenbendazole
Sorry you have pancreatitis too! I am also on keto and IF (to prevent sibo). Did carnivore for a while. Felt great but was worried it would burden my pancreas too much. My pancreas is severely damaged and supplementing pancreatic enzymes made me sicker i.s.o better. No support from doctors here, so on my own to figure out how to best manage my symptoms. Keto and fasting are very far from the protocol in Holland. Interested to know why you chose to do keto and how it's helping you.
@@Healthy-Golden-Oldie Like most people who fast and do Keto, I started after everything else failed. Best of luck with your health.
I wonder if Thomas Seyfried's research on cancer as a metabolic disease might give you additional help. His metabolic therapy is outlined in his book. It's a strict therapeutic type of keto.
Aside from that there's also what others have mentioned: ivermectin, fenben (and the human version, menbendazole).
Hope this comment doesn't get deleted!
Fascinating!
For those of us with ketone monitors at home: LET THE TAHINI EXPERIMENTS BEGIN!
Go 4 (mM) it!
I tried 2 tbsp sesame last night and I'm in very mild ketosis (.6 mmol/L) today even though I haven't been eating a ketogenic diet the past 4 weeks while I was on vacation. Can't wait to try this when I am actually eating a keto diet again!
@604jroe any update?
Please put results so we can see how tahini affects people
I bought some tahini because of this video and find that it is almost intolerably bitter. Is this how it should taste or is there something wrong with this product? I bought the exact brand that Nick shows in this video. Maybe it is an acquired taste.
The research this man is doing will revolutionize what we understand about health and nutrition
Cheers brother.
@@nicknorwitzPhD Do you have a video on LA fat VS DHA?
Nick your channel is the best, I love the fact you report on real studies and present in way us meer mortals can understand, I have severe (anaphylaxis) egg and nut allergies all my life, which are counter productive on Keto, but I am good for sesame seeds, so I'm going to give Tahini a go...
Thank you so much for your posts, I'm learning everyday... I also beat stage 4 colon cancer on Keto with fasting, without any chemotherapy, but I did have the tumor remains removed in 2021... I was given a 40% chance of surviving 2 years... Today I am cancer free...
So glad you find them helpful. Amazing personal story. Thanks for sharing
Rectal cancer here. main tumor still present. i refused TME bc, well, bc it would have been stupid. lucky yrs was removable. i would have had a permanent colostomy, and most ppl i know with low rectal tumors wind up dying anyway despite SOC "care" bc of local recurrence or mets so i'm v. happy 4 u. xoxo and u give hope to many.
I’ve read widely about and been in ketosis for most of the last twenty years but this is the first I’ve heard about the sesame oil/butter ability to ramp up the ketones. I really enjoy your vlogs; thank you for making all this incredible content.
Too bad I lost trust in medical research. We knew from the 60s about Keto, and food pyramid is still pushed on us. There are entire aisles in Grocery store that should be illegal and there are still advertised as heart healthy. 🤨
What's insane to me is how some companies somehow get away with no nutrition fact label or blatantly false info on their nutrition facts. Like how a zero calorie Gatorade is only zero calories because they defined a serving as ½ a bottle but then the cals per bottle are 5. That math ain't mathing. Makes me now suspicious of everything that claims to be zero calorie.
There’s a loophole in nutrition labeling rules that they can declare 0 calorie if the product contains 2.5 calories or less per serving.
Sometimes I imagine everyone should be a lawyer so we don’t fall prey to many loophole in law and regulations.
@@TravelingFoodBunny yeah I figured it's a loophole.
The majority of sick people don't follow the food pyramid. Yet everyone is blaming the foods people don't eat. How come a few decades ago, vegetables, fruits, tubers, some grains, dairy and meat were fine. Unfortunately, we like convenience and that comes at price. I wish people used a little of common sense and stop this nonsense that keto or carnivore is some sort of holy grail of nutrition when it's clearly not. That's not to say it can't work as an intervention.. I believe sticking to such a diet makes it easier to avoid processed foods
No one can afford animal foods
They have to keep diet affordable
Nick is one of the most reliable and informative scientist on TH-cam.
Thank you! So Nice
@@nicknorwitzPhD So which metabolic scientific textbook do you recommend? (Price isn't a problem).
True
@@keylanoslokj1806 @nicknorwitzPhD Yes, pls pls pls provide a list of best sci/med school textbooks. PLEASE!!!! xoxo
I have been waiting years to hear someone even mention that some cancers can thrive on a fatty acid fuel source. Fascinating stuff! Thank you once again.
Welcome!
Is there a reference paper describing cancers using fatty acid as a fuel source?
I dont there are any studies that show this - this is an assumption .. I would be very interested in seeing any studies showing any cancer can use ketones for fuels
@@taezzzer ketones maybe not. But do a search there's lots on cancer utilizing fatty acids.
@@geoffreylevens9045Just to put a finer point on this, I’d like to see a study showing fatty acids used as a fuel. My understanding, per Thomas Seyfreid, is that glucose and glutamine can be used as fuels.
My question is what other molecules act similarly. Thanks!
Interesting mice study at the end. When I had cancer (Melanoma) and get it worse to stage 4 I was scheduled to start immunotherapy treatment. I began going very hard keto (25g carb, high fat - low protein ratio, taking exogenous ketones in morning to ramp up it up) just as my treatment started. I can't say with any kind of proof but I'll always be convinced that timing them together like that worked in my advantage so that it provided an extra shock to the cancer cells (starvation via keto, immune enhancement via treatment) before they had time to adapt which allowed my body to get rid of the cancer.
Y'all really ignoring the best immune enhancer in the world: vitamin E
Ok, Nick, now all you have to do is tell us how to activate the 4E inhibitor, and we can cure pancreatic cancer! Snap! I always watch your posts, and yeah, sometimes you get slightly technical, but you provide way more info and divergent subjects than most of the sites, with the possible exception of Nic on Physionics. The two of you must attend the same comedy workshop, the jokes are worth the price of admission.
"eFT508 (also known as tomivosertib)" is an inhibitor.
So in a nutshell, 3 to 4 tablespoons of sesame oil or tahini with dinner before a 24hr fast will increase ketone levels equivalent to a 6 day fast.
I hope so, ima try it
Thought I was fit and healthy to begin with.. surely everyone is tired after breakfast and lunch, has headaches and uses the bathroom three times a day right? Went no/very low carb (less than 25g per day) out of curiosity and boy oh boy did I have no clue, what GOOD felt like. Limitless energy, bodyfat went from 10.5 to 6.5 with zero muscle loss, laser focus, mental calmness - cuts heal in record time, my testosterone is through the roof.. that feeling you get when a cold is knocking on your door? Gone the next day. And I'm just in low to mild GKI ketosis (0.5 to 1.5 mmol/L) I will never ever go back to eating carbohydrates, knowing how that misery is not NORMAL.
I had a similar experience. Went keto for a year and felt fantastic. While I still primarily follow a keto diet, I’ve introduced some carbohydrates into my meals. This is because consuming too few carbs can, paradoxically, lead to insulin resistance caused by persistent excessive glucose production from constantly elevated glucagon levels.
To prevent this, I now ensure that I consume some carbohydrates with each meal so as to limit the need for glucagon release to support normal blood glucose levels.
@@mjoh090 I am unaware of any study showing it leads to IR. It can lead to adaptive glucose sparing, so morning glucose can float up as you don't need it any more. But a proper OGTT or OGTT with insulin will likely show you are still insulin sensitive on keto. Even a simple postprandial glucose test will probably be enough to show you at home you are just fine. The "physiological insulin resistance" that some people talk about is during pregnancy. check InsulinIQ Channel by Dr. Bikman,
Isn't borage oil or primrose oil a better source of linoleic acid, than sesame seed?
And are you sure this enhances your ketone levels more than MCT oil, or simply coconut oil (which contains MCT-oil and isn't so tough on the stomach like pure MCT-oil)?
Nick, my nephew has pancreatic cancer. PLEASE tell us more about the inhibitors. How/where can we get them and combine them with the ketogenic diet? Please.
Sending love + light to your nephew. May you gain all the info needed for a full and miraculous recovery.
I lost my father to it, I'd like to know too
'Can a keto diet eliminate cancer growth? Dr. Thomas Seyfried says yes'
'The press pulse strategy' part under this video.
Just happened to listen and then saw your comment.
Hope not out of context, I'm new to keto.
Funny how 99% of our food is processed. Anything the FDA says to eat I just do the opposite. I recommend reading “Health and Beauty Mastery” by Julian Bannet, that book is a real eye opener about shocking stuff health industry is doing! I completely changed my habits
Exactly!
Lot of people talking about that book lately
Yes, unfortunately it's all about profit, nothing more, nothing less
I wish there were a better description for UPF which didn’t use the word ‘food’.
I don't know what the book says, but you do realise that the "big pharma doesn't want you to know this" shtick is schoolbook sales talk to fool you into thinking they have some special secret?
Be careful not to be fooled by snake oil salesmen, in your process of trying not to be fooled by big pharma
What I appreciate most about you is your intellectual conscientiousness. Often, I observe most “science-based” media hastily refer to studies to justify advice or health claims, without any further discussion of the results, hypothetical or theoretical mechanisms. Rather, you offer a deeper and broader scientific perspective that- I think- provides a relatively much greater net good to the consumption of media.
Dr Bikman discussed which fats are best to generate ketones in one of his videos. His position is that body can't store shorter chain fatty acid (8C or under) so they are turned into ketones. According to him this is why MCT oils are so effective for raising ketone levels. Oleic and Linoleic are both C18. How does it work then?
I was going to say just use MCT oil for Ketones
@@doddgarger6806 For many of us, MCT oil has adverse GI effects, even at low doses and after habituation. Sesame seed butter (tahini) has a better GI and taste profile though it has some carbs (and protein as well). I'll try it. :-)
@@geopietro but apparently high in oxalate and also high in carbs. 😞
MCTs have a different metabolism whereby they go via the portal vein to the liver and also don't need a shuttle system to get into mito so they burn faster... the 'sesame effect' is more delayed, but I find gets to higher levels. I know Ben well. Good guy. Good friend.
@@geopietro Tahini is a high oxalate food.
Preferred vs prioritized question:
Does linoleic acid have negative effects past the body's need? It makes sense that the body would prioritize conversion to ketones once need is supassed so that remaining form is benign.
I would like to hear what happens when
1) The omega 6 to omega 3 ratio is maintained but the percentage of calories is increased.
2) Just the omega 6 only is increased (like the video) past bodily needs
3) Just the omega 3 only is increased past the bodily needs
4) Long term effect on inflammation and cellular lipid profiles.
Would this show that the body readily handles the polyunsaturated fats that are not needed for biological functions into the ketone form as suggested in video.
Then what does this mean -- does prioritized ketone generation in context of polyunsaturated fat mean preferred calorie source or prioritized for cinversion/disposal?
As a parallel, doesn't alcohol get converted to ketones by conversion to acetate while simultaniuosly blocking glucose metabolism rasing ketosis allowing for prioritized alcohol disposal through ketogenesis and utilization?
I see Nick post I watch
Good choice!
So what do u have to eat/take to activate that inhibitor to kill pancreatic cancer?
Nick, Great video. I'm on week three of a sardine fast. I eat three cans around 3 pm every day. I also take three tablespoons of MCT oil daily. My ketones run between 4 and 6.5. This program is extremely easy to maintain. My question to you is ... what is it about sardines that jack my ketones so nicely? It's better that a 72 hour water only fats for me.
Omega 3 is also unsaturated so maybe has the same effect. I’ve heard it works well for ketones too.
I also love doing the sardines fast. Next time I will take sesame butter the day before I start my fast
First ... poor mouse . I had pet mice as a kid . Second ... your channel is so fascinating. Third ... it's a weird experience to go to the GP and realize they are lagging so far behind in their knowledge of metabolic health .
Sorry. Thanks. Too true... sadly
Doctors are taught how to keep you alive in the hospital. We are not taught how to turn your body into a high performance machine. That's as far as our metabolic knowledge goes and yes, it is good enough to save your life.
@@jeremynass2040 it's also bad enough to end it .
Med school curriculum changes at a snail's pace. My doctor friends and in-laws all say they learn almost nothing about nutrition.
You should do a podcast-youtube video about the last point with Dr. Seyfried, that would be an amazing discussion! As always great vid!
At this time I don't host convos on this channel. At some time in the future, I suspect I'll have a podcast... then...
@@nicknorwitzPhD Nick, making good decisions! Yes, I watched your Valedictorian speech that Eric posted! Great speech!
@@michaelpadula2943 link, pls?
Great way to start the week! Really so much fun to learn this content. Thanks Nick!
Glad you enjoyed it!
Hi Doc, you are my most trusted Doctor on the internet, I like most of your content, just want to ask you something, from whole food to keto, how do I do it safely? I am 65 year old man.
Thanks for the kind words. That's a very broad question. I think if you tend to eat a whole foods diets, low in sugar and processed foods and with sufficient protein, you're a good deal of the way there. If you want support, maybe a dietitian specializing in ketogenic diets, or a community group filled with people with experience who might be able to offer tips. Without knowing your medical background, I can't give more specifics. Sorry. Even were I to know your history, a TH-cam comment isn't the place to give personal advice.
I hope you get to research a whole bunch of keto for beginners videos. You'll get a feel for the most common transition problems. Usually those have to do with avoiding the keto flu with the help of electrolytes.
On top of finding individualized help, I would suggest taking a look at the beginning tips and methods from Dr. Annette Bosworth (Dr. Boz, she has a good workbook you can add to your library, "Keto Continuum"), Dr. Eric Westman and Dr. Ken D Berry just for starters.
Dr. Tim Noakes recently put out a comprehensive book, "Ketogenic", which might be super helpful as well.
Transitioning might take around 3 weeks, and then fully fat adapting might take at least 3 more months. Dr. Stephen Phinney and Jeff Volek did a lot of foundational research on keto. They have books as well as vids on it.
Good luck!
Nick, love listening to your takes on latest studies. You make it so much more translatable for the lay person.
Thank you Anne! very kind!
Game changer for my ketosis journey.
GL!
Dear Dr Nick! Thanks for this. FYI: 4 T tahini has 12 g carbs. Yikes! Plus, diners must prepare tahini to eat it to avoid solvent flip and choking problem. Simple 2 serving recipe: weigh into cereal size bowl 120 g Tahini, 60 g water, 1/8 t Redmans pink salt, 1/4 t garlic powder, 1 t vinegar, and mix with wisk. Please add to notes. ❤❤❤
I’m thrilled to try adding tahini to boost my ketones. You’re awesome, Dr Nick!!
6 grams net carbs actually per 1/4 Cup (Tbsp)... that's ~ 6% kCal from carbs... sounds keto to me. I don't think Tahini is a choking hazard. Thanks for the recipe suggestion.
I have Trader Joe's organic tahini and it has 3 total grams carbs per 2 Tablespoons. So 1/4 cup has 6 total grams carbs.
You deserve way more subscribers! I am glad you can research this stuff and present science to us.
Thanks! Growing fast... will get there... :)
When my husband was battling pancreatic cancer I was reading every research I could find on its pathways. None of them mentioned ketones.😢 In fact his tumor initially shrunk, not sure if it was due to Folfirinox or the fasting he did during chemo.
I was little confused on pancreatic cancer issue. Guess I’ll need to listen again. Have a friend with pancreatic cancer and just trying to learn as much as I can.
Congratulatiions on 100,000 subs! I just noticed it. Keep the info coming!
Thanks! Will do!
Nick, you are TRULY moving to the forefront of "online" , highly qualified, metabolic research diffusion. Always cutting edge. Thank you !
Thanks so much :)
How relevant are the levels of ketosis? Anything that allows one to reach 5 rapidly evokes suspicion. Moderate levels long distance seems comfortable. Not to dismiss the peculiarity of the tahini effect. It would be interesting to see further studies in this direction.
Watching Dr Seyfried’s numerous videos not ones have I come across his mentioning of the pancreatic cancer’s ability to use ketones for fuel. He specifically emphasizes that ketones are never used as fuel for any cancer. Perhaps something went amiss. Most likely on my part.
I have heard Dr Seyfried qualify this by saying that cancer cells cannot use other fuel sources besides glucose and glutamine for a meaningful length of time. They may use it for fuel in a very short term situation but cannot survive on other sources in the long run. Perhaps that is the confusion.
@@Margaret2494 yes. He says glucose and glutamine used by cancers for fermentation. Listened to his videos again today, specifically stated that all cancer cells follow the same pattern and there was no cancer that uses a different pathway.
I'm blown away with this! Thx you are out of this world Nick
Cheers! Thanks for watching and commenting
So GLAD you brought up the benefits of seeds oils like tahini. Everybody just thinks they are the devil, but as long as they aren't refined, I have no problem with them. I'm starting keto today, so I will be purchasing some tahini to help jump start it, thanks for the hack nick! Edit: I just bought a bottle of organic unrefinied untoasted sesame seee oil
While It may greatly increase ketones, it might still be a net negative.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10386285/
@@adim00lah Tahini is sesame paste (unprocessed), NOT sesame oil.
When people speak of “seed oils” they mean industrially processed seed oils
Enjoy!!!
@@nicknorwitzPhD Sesame seed oil works or do I have to use tahini?
That insight about getting ketones higher using LA could improve the lives of many suffering with chronic disease symptoms, kudos to you Nick, well done ✨👌
Had to watch it twice. Again, thank you.
Thanks for the algo juice :)
@@nicknorwitzPhDI'm surprised I didn't see an ad for ketone test kits, because now I actually might want to buy one!
Brilliant. "Mastering metabolism" has never been so wonderfully informative. MnM's. Thanks Nick, you are the best!
Cheers! Appreciate it!
Nick, How does tahini fair against MCT the usual boost into ketosis?
Yesss! I really don't want to eat spoonful's of Tahini...blech!
@@ellieb2914 tahini tastes great, when combined with corn syrup, eggplant 🍆 purée, or chickpeas. However, I don’t want to eat syrup again, and I don’t want to consume hummus or baba ghanoush frequently.
For me, tahini is more powerful. However, it's a longer term effect, e.g. next morning vs MCTs which have a more acute bump.
MCT still wins for me simply because it has practically no flavor so it is easily used in dishes without screwing up the taste.
Simplest solution is to eat unprocessed foods and stick with the whole foods and stop vilifying fats. ❤thank you for explaining the importance
I tend to agree:).
Interesting that something like tahini pushes your Ketones higher quickly. Considering it’s not a readily available foodstuff in nature you have to wonder if having high ketones is such a great idea? If most people take a week of fasting ( starvation more or less) to achieve the same then it’s not really something a hunter gatherer would try and do the aim being to find food and therefore not get into deep ketosis.
I'm not sure hunter-gatherers had ANY intentions with respect to ketones. The reality of their life was that there might have been long gaps between feasts. Also sesame had limited distribution in nature (India and sub-Saharan Africa) before it was domesticated about 3,500 years ago, too soon for me to include it in the 'what were evolved to ' list
@@cassieoz1702 yes I don’t think nature gives a rats arse as long as we reproduce? I suppose even then does it? Longevity without reproduction?
Amazing stuff NIck! As a scientists, I can barely dig through the countless studies but you seem to have a nack for finding these gems. Keep spreading the science!
Would you consider making a video addressing Paul Saladino's claims about linoleic acid and keto diet safety?
I agree on the linoleic acid! I disagree on the keto safety, he cherry picks studies like crazy and most of the studies he cites are 2 week durations the most.
@@joeberrouard3743 SALADino CHERRY picker KING!
This is the type of stuff that motivates me to continue physiology and human nutrition studies! So so cool :D
Awesome! Love it!!!!
Hi Nick, thank you for bringing this study to our attention. Given the results, would you advise a ketogenic diet for people with pancreatic damage / fibrosis due to acute or chronic pancreatitis? Would keto enhance the risk of developing pancreatic cancer?
I don't think anything I said in this video generalizes to pancreatitis. And no, I see no reason to think ketosis would increase the risk of developing pancreatic cancer.
@@nicknorwitzPhD Thank you Nick, no you didn't, I was just wondering. Damage from pancreatitis enhances the risk of developing pancreatic cancer. A constant worry. I wondered if being in ketosis could increase that risk.
@Healthy-Golden-Oldie I appreciate your inquiry, being of personal relevance.
Am committed to learning more on it.
Be well 🙏
I have two questions first you are already on a ketogenic diet and you do this 4 spoons of tahini? the second one what's your keys are ketone level after 16 hours of fasting?
Dude, youre the man! Such awesome knowledge you impart to us all. Super appreciate your energy and desire to help us all out by learning more about our awesome bodies! Yew!
Thanks John! Awesome comment!
5:15 How long and stable is the increase? Do polyunsaturated fats get a priority when it comes to fuel because they're less stable when kept around (e.g. polyunsaturated = liquid jet fuel; saturated fat = solid jet fuel)?
Increase occurs next day for me (if I dose the sesame at dinner) and remains stable until I eat that day.
question - How does eating an external fat like sesame oil, translate into the burning or utilization of stored body fat which is why most people start a keto diet in the first place.
Very interesting 😮 I wonder if it's the longer chains of fatty acids that instigates the metabolism to burn more fats. What if one was to try mustard oil, which has VLCFA. It's high in erucic and brassic acid, which have 22 and 24 carbon chains?
Long chain stearic acid upregulates fat metabolism. It's the basis of the so-called Croissant Diet.
Thanks for sharing all your knowledge man. I’m trying to reverse my heart failure and you are the best at getting to the bottom of the problem
Great stuff Doc! Thank you!
My pleasure!
Congratulations on 100K subscribers, Nick! Well deserved! You make excellent content and your self experiments are so informative and revealing. Oreas and eggs…. Oh my!
Dr Ben Bikman is my favorite, and I’m positive he knows how ketones work!
I think this paper would be new to Ben too ;), at least at the moment I'm writing this comment.
@@nicknorwitzPhD
The study comes to conclusions most of us watching are prepared to accept due to our biases. But, you entirely gloss over it. Since you have access to its entirety and are making a video about it, it would be more helpful to provide insight from behind the paywall.
The proximal origins of that thing was also published in nature. Along with lots of redacted articles. Serious question, why do you feel this study is accurate?
This is one of the most interesting videos in a while. I also like your keto hack.
Happy to hear that!
Hi Nick. Your work and content is very impressive and thought provoking. Keep up the great work. Question. Curious about your thoughts on LDL fractionation data. I've been low carb and health focused now for about 4 years. Biomarkers are improving. I'm 60 so not a kid. I have CVD and atherosclerosis. I started doing much more red meat and even lowered my statin about 3 months ago. My LDL Particle number went up significantly and so did my small dense LDL value. Seems counterintuitive. Curious if you have any thoughts on the subject and if you feel that those are valuable biomarkers. Dr. Brewer really focuses only on Large HDL. Keep up that great work.
measure your ApoB!
@mbrochh82 thanks. My apob is good. Are you thinking the ldl fractionation is not valuable?
When I was on the Atkins diet in 1979, I ate lots of sesame seeds. I bought them in bulk.I really likes the mouth feel.
Yes bro! Savin my life here.
Appreciate you!
What are the readings for your ketones after 16 hours please
Nick, how long does it take to fully be keto adapted. I am on week 3 of keto , and even though I am getting enough fat, protein, and electrolytes, I still feel pretty tired and weaker. Any thoughts? Also, how in the world are you so strong and can do 230 pushups at 14 years old? Or are you just a special case, or can anyone work toward something like that?
5:24 Wait, linoleic acid ? That's an omega-6 right ? Isn't that pro-inflammatory ?
Could the same be achieved with omega-3 fatty acids ( given that it was a bout unsaturated fats) ?
I’m wondering that too. I know people get larger ketone numbers with sardines, so I suspect yes. In fact, that’s why people do sardine fasts.
Great video, Nick. It’s a pity a lot of the comments take the information you present out of context, but glad you share the information that you do and hope you continue to do so.
Inevitable... sad but inevitable.
He didn’t mention how to lower elf4e so I’ll jump in here for him.
Capsaicin affects eIF4E activity indirectly through its impact on the PI3K/Akt/mTOR pathway. Capsaicin can inhibit Akt phosphorylation, which in turn affects mTOR activity. mTOR increases eIF4E activity by inhibiting 4E-binding proteins (4E-BPs), thereby promoting cap-dependent translation. Therefore, capsaicin may reduce eIF4E activity by modulating this pathway, potentially influencing processes like autophagy and apoptosis in cancer cells.
Thank you. This is why I love the comment section. 👍
It inhibited, but did not stop nor reverse PC tumor growth. Slow is certainly better than fast, but a different key is needed.
Tahini contains high levels of oxalates, phytates, and some tanins.
Hey, how you include search TH-cam results and link as word in your comment?
You're totally entitled to make your own food choices based on what's most important to you.
Seems like a good point worthy of a response. Nick, is it that the benefits outweigh the costs mentioned by previous commentor, or are the objections somehow invalid?
@@walterwilkinson1499 its not a perfect diet world... simple. Pay your money and take your chances. Most of the middle east lives off tahini and way back into the mists of time
@@lauchlanguddy1004I wouldn't say 'lives off'. They eat waaayyy more fatty red meat in the form of lamb and goat, remember.
Really respect what you do, congrats on the 100k subscribers you're about to have any moment now :)
cheers... yep will happen in an hour or two :)
So if I understand this correctly would MCT oil also be a good substitute for the sesame seed oil in raising ketones so much so that it is better than butter as well?? Great content!!
I can't eat most plant material, but if I want to increase ketones fast then I eat MCT or just plain coconut oil. MCT is faster but coconut oil is just as reliable and last a little longer.
Goat butter has higher levels of MCTs. I use cultured goat butter from Mt. Capra. The culturing breaks down the fat molecules and makes them more quickly bioavailable. So, goat butter should be one of the most ketone-boosting sources of fats around.
Also, consider that monogastric animals will store whatever fats they eat. If pigs and chickens are fed linoleic acid and MCTs, that is what fat will be available in the foods procured from them: meat, eggs, lard, etc. But such foods would be hard to find on the mainstream market.
I only heard him talk about LA being more ketogenic than butter, and hinted that unsaturated fats would be more ketogenic that saturated.
Since MCT oil is virtually all saturated, why do you think MCT would be more ketogenic?
MCT have to be burned so definitely very ketogenic they can't be stored
@@mlaroche2009 - We know from old and well established research that MCTs are easily and rapidly converted into ketones in the liver. It's been a common practice to use MCTs in the medical application of the keto diet to treat disease.
But it's also a widely known keto hack among keto advocates and in the keto community. Many stores that sell keto products will sell MCT oil in the same section.
You can find thousands of research papers, popular articles, and TH-cam videos about ketosis and MCTs. Also, I've looked at numerous books that discuss ketosis and keto diets, and they typically will mention MCTs.
So tahini butter acts like mct c8? Have you tested C8 to see how high your ketosis goes? Cause c8 can produce ketones even when eating carbs..
I do OMAD so if I eat 3 tbsp of tahini with my meal I should lose more fat?
Spoiler alert .. @4:38 - Hack re: ketogenic fat sources. So, basically the sesame oil with the linoleic acid acts as a singalling molecule. So how can I best employ this? Take a dose of sesame oil, and then fast for 24 hours? We should be able to test this ourselves (Is it still 'N of one' then?). Please add any further details, tips, or testimonials if you have them!
A good experiment for me will be 1 cup tahini, 1 egg, 1/2 cup allulose, bake at 350° for 10 min. Basic test recipe for Tahini cookies.
Yummers!
How many carbs does tahini have in and I'm wondering what if there's authentic keto friendly healthy tahini verses cheap Walmart tahini. I know ghee can be made very badly form vegetables and seed oils. Do you know anything about different products. And lastly did you do the experiments with the cookies. Did it raise your ketones? I've been back on meat heavy keto for a few weeks and haven't got my energy back or lost weight. Thanks for the recipe. I may try it either way but was curious.
@@aidanpoulter9514 it's >94% fat and protein by kCal... 3g net carbs per 210Kcal serving
Linoleic acid (Omega 6) really(?) What about the balance with Omega 3? Is it that in a deficit it is only burned without being stored and damaged? How does that affect fat loss?
So interesting< thank you for sharing this value information.
Welcome!
Fascinating -
Due comments here about fasting and ketosis,
would appreciate Dr. Norwitz's analyses (or of any reader in the comments) of the "5/2 diet"
.....eat normally five days, fast two.
The two "fast" days are not true fasts, and are not consecutive days -
...merely under 600 calories for men, 500 for women.
My unscientific sample size of one results -
From 194 pounds to 165, over five months - College weight and tone.
High school isn't a good compassion.
As I entered college at 17, I was still growing until about age 19 or so.
..and didn't really need to shave until my early 20s. TMI? :)
FMD fast mimicking diet
Because Longo doesn’t understand fasting is NOT starving
Either eat
Or fast
Starving is a stress on the body
Fasting triggers all sorts of positive response
@@YeshuaKingMessiah
While I'm grateful for the good works, accountability, and morals that Christianity teaches
...Jesus was a false Messiah, per the very Bible in Christians profess knowledge.
The Bible is clear, when the Messiah comes:
1 - He will not be divine
2 - The entire world will worship God, and know he is the only true God
3 - There will be no more war
These prophets, in which Christians claim 100% validity,
state that we can recognize the Messiah when all of the following take place during the Messianic Age:
Ezekiel
Building of the final Temple that will stand forever in Jerusalem
Deuteronomy 30:1-5
Return of the lost tribes to Israel
Daniel 12:2
Resurrection of the dead
Isaiah 11:9, 10
Knowledge of God throughout the world, and obedience to God
Isaiah 2:4
Nation shall not lift up sword against nation, neither shall they learn war any more.
None of the above happened 2000 years ago/ Jesus fulfilled no prophecies
Result?
Church leaders after the year 100 invented
..."Jesus, The Return" aka The Second Coming.
Then in 325, the Church invented the Trinity at the Council of Nicaea.
Yet the Bible explicitly states that God will never be split into parts, and only God is to be worshiped.
Sorry, you're been misled.
Not your fault.
Ex -
Church claims that Isaiah 53 is about Jesus have been endlessly debunked.
This has been a classic tactic of Missionaries.
Good hearted and sincere for sure, but deceived.
Almost always by Pastors, who in turn have been deceived.
The Servant noted in Isaiah is the Nation of Israel, not the Messiah or Jesus.
Isaiah 43-10
"You are my witnesses {plural}, declared the Lord, whom I have chosen"
Isaiah 43:11
"I am the Lord.
Besides me, there is no other"
Why do you think these verses aren't taught to Missionaries,
or spoken of in any Sunday Church service?
Be honest.
Because these are yet another proofs that -
1 - The "Servant" is the Nation of Israel,
and that the Jewish people of today worldwide are Servants, not Jesus.
As all Jews are members of the Jewish Nation, regardless of passport.
2 - The Trinity's invention in the year 325 has no foundation in the Bible.
In fact, it's directly opposed by the Bible.
Clear to anyone who reads the entire book, rather then cherry pick select passages out of context.
What does it say in Isaiah 52 and 54?
Why is only 53 taught to Missionaries, and accented, but others ignored?
Per the Hebrew Bible,
again in which every Christian denomination claims is 100% valid....when the Messiah finally does appear-
Zechariah 8:23 holds -
“This is what the LORD of Heaven’s Armies says:
In those days ten men from different nations and languages of the world
... will clutch at the sleeve of one Jew.
And they will say,
‘Please let us walk with you, for we have heard that God is with you.’”
@@MarcPaganCohen u can’t figure out if ur an atheist, or a dietist with a non-triune god?
I appreciate you, Nick
Thanks! Appreciate you back!
Serious question. Is the sesame seed oil not inflammatory?
Nick, if I was half as smart as you I would be twice as smart as I am. Thanks for all you do - You make and keep me curious!
You're always so supportive and kind. Thanks for being you
So, is there any practical benefit to raising ketone levels so high, I mean other than feeding my pancreatic cancer?
Just what I was thinking.
Higher levels can be therapeutic in some conditions. And if you look at the data... it's not 'feeding' cancer/making it grow.
This channel is not for the faint of heart……,really want to understand this guy…..whew…but I love it
What do you mean?
He was pretty clear to me 🤷♂️
@@tedarcher9120 i love this guy,,,,I have a hard time keeping up with him though..,,..I have no education on any of this, so I want to understand it….but it’s hard for me…no complaints here,.he’s great, He knows the science…..it just goes over my head
He is a phd researcher. He uses normal terms for phd researchers. It is worth learning what the words mean.
Thanks! Very kind!
WOW! This is huge on pancreatic cancer cells!! Love this but still many questions on the Omega 6 FA considering the need for balance of Omega 6s/Omega 3s, also the high levels of ketones, also other side effects of seed oils considering the problems with many of them being rancid.
Fabulous, well done sir!
Thank you kindly!
what about sesame seed oil's omega 6 to omega 3 ratio?
Tell me, why is that measure of intrinsic value to you… think deeply about that for a moment…
@@nicknorwitzPhD hmmm, inflammation? or am I mistaken on this...
Dr. Seyfried would argue that the secondary cancer fuel would not be ketones, but glutamate.
(actually, glutamine) and he said he is looking for cancer cells that can use anything else beyond glucose and glutamine for energy, maybe Nick should talk to Dr Seyfried ;)
Exactly
@@doddgarger6806 That caught my eye as well. According to Seyfried, cancer cells can't metabolize ketones, because that can only be done with working oxidative phosphorylation, which cancer cells have lost due to extensive mitochondrial dysfunction, and which is precisely the reason why they had to upregulate fermentation and become cancerous in the first place, using glucose and glutamine as the substrate.
Came here to chime in about Dr. Thomas Seyfried @TalkingCancer-u4k, but I see it's already covered, thanks!
Seyfried hypothesises that the reason these studies see higher cancer cell ketone "uptake" in a ketogenic state is because ketosis promotes mitochondrial uncoupling, resulting in more mitochondria and more consumption.The fault with these studies as he puts it, is that they automatically conclude the cancer cells are sufficiently producing enough energy from the ketones to survive, when what they should be doing instead is measuring energy production, while simultaneously removing the alternative fuel glutamine. His team has tested this for all major cancer cell lines, including pancreatic cancer.
I'm learning so much from your channel, and I'm on day one. Thank you.
Very cool. I stumbled onto nuts, simply because I have always been a keto vegetarian and as a keto vegetarian, I needed to get enough calories to cover my 2400kcal BMR and nuts were one of the only plant fat sources with sufficient caloric density to allow me to meet my requirements without overstuffing. I was not aware that the nuts were directly contributing to my ability to rapidly switch into ketosis.
Very high in oxalate and phytosterols which disrupt hormones and are highly oxidizable
Not to mention nuts combine carbs fat and protein which actually drives insulin very high not a healthy thing for us
I also really enjoyed deluxe mixed nuts on keto up to the point I ended up in the ER with a kidney stone of the most common calcium oxalate variety. No more nuts for me after that as nuts are very high in oxalate. I learned my lesson, no more nuts for me. Straight carnivore ever since.
@@petertownsend252 I have been vegetarian for 5 years. Never any stones. Note that I am vegetarian and eat dairy, which provides the calcium to bind the oxalates, which is why I have never had any stones. I also have an ample supply of k2 to then take excess calcium into bone and away from arteries. I have zero arterial calcium.
Btw all nuts and seed I eat are raw. I consume about 100g of a mixture Pecans, Walnuts, Brazil nuts, Macadamia nuts, pine nuts, sunflower and pumpkin seeds. Based on the information in Nicks video I will add sesame seeds.
@@homomorphicI thought the benefit of roasted nuts would be reducing the phytates.Why do you prefer raw?
@@geode232 Because roasted nuts have advanced glycation end-products. AGEs occur at high temperature. I never eat foods that aren't raw, boiled or steamed (where the heat can't be much above 100 degrees C).
Did you rule out if the lower count was reflecting the body’s adaptation to using fat stores efficiently for energy as in butter being more bio available and readily absorbed by the body as compared to a fat source from a seed?
What other food sources of fat could provide similar effect??
MCT
Best guess based on fatty acid profile: pecan/pecan butter, walnuts.
@@nicknorwitzPhD, I don't think I've ever heard you saying you eat any vegetable... Have you thought of trying to experiment this with a keto person using avocado?
@@Joe_C. Lol my next n = 1 is vegan keto
@@nicknorwitzPhD 🤭... Sorry, I always chortle a bit when I hear vegan keto 😜
Am sooo glad u r addressing the difference in fats. btw, in me protein leads to higher BG presumably bc of gluconeogenesis. Stage IV rectal cancer here. DId NOT do all SOC "therapy," ergo am still thriving, but that which I agreed to led to ill LT fx. I wish I could do meat-based keto, but my GI luvvvs high fiber. Raw is best 4 me. A raw beet or carrot does NOT raise BG by even 1 pt. Cooked veggies do. But too much arginine in nuts (sob sob). Will try tahini but will also be wary of amino acid content bc of tumor ability to make glutamate from many amino acids.
AWESOME INFO thank you!!!
Welcome!
Linoleic (Omega 6) 🤔 but how does that affect to reduce body fat?
Ur video about eggs made the newspaper (digital) in my country 😂 they were sceptical, as mainstream media always is
They're never skeptical reading their scripts though 😅
Ya... it's gone crazy viral. 10s of millions of views cross platforms.
@@doddgarger6806 true XD
I think What I've Learned did it a year or 2 ago also if I remember correctly.
@@nicknorwitzPhD You also made it on either Gateway Pundent or Citizen Free Press. Can't remember which one it was. Very surprising!
Good info, but what a mouthful of jargon! I'll have to listen to this again tomorrow, maybe it'll penetrate my thick skull.
I am attempting a fast - drop insulin & glucose & triglycerides, etc. Question - does ketosis trigger autophagy (no protein, and protein is a builder)? Or does autophagy need total fasting (because ketones are an energy source). The reason for my question is - if autophagy is not affected by ketones, then eating some fat will help reduce hunger pangs.
I read low on ketones, and havemt had a carb in 5 months. Gonna try this tahini for fun
12g carbs in the therapeutic dose
That a hard no
GL... the sesame oil might work a tad better if you're optimizing for BHB... have with very low carb dinner and then fast overnight and for ~20 hours... see what happens.
Not sure where you're getting a 12g number. 6g net carbs in 1/4C Tahini with >94% kCal from fat/protein
WHy is BHB that high good? Some influencers think that that's keto acidosis and is dangerous. If I feel great on carnivore, do I need to chase that? Also, what about processed nut butters and seed butters being oxidized and rancid - and pro-inflammatory? I realize they're not industrial seed oils (which give me migraines), but I am worried about them. What about oxalates in these nuts/seeds? And other plant toxins?
Another terrific video!
Thanks Alicia!
One of the genetic variants I look at are those in the FADS genes, relating to liver phosphatidyl choline and the inflammatory potential (or not) of linoleic acid. Tend to find that folks with high linoleic acid (on an omega 3/6 panel) often have low arachidonic acid (too low) and highish inflammation. Those people I caution against relying on high linoleic nuts (I thought macadamia nuts were low in LA??!!) to reduce inflammation. Long intro to question: have you looked at any side effects of inflammation in these tweaks?
These videos are so much better when the springbok on the rugby ball is clearly visible, like in this one
haha! Noted.
I looove this fast-paced uber-geeky presentation. only left hanging on how to obtain the (ED4 whatever) inhibitor that slows pancreatic cancer in the presence of a ketogenic diet...just in case I or anyone in my circle should happen to get diagnosed. signed, old lady walking encyclopedia-type always wanting to help 😁
EIF4Ei is a pharma grade drug... if you have pancreatic cancer I think you should seek professional support form an oncologist - obvi
@@nicknorwitzPhD obv 😁 I'm just an info-hound. God bless 🙏