Celebrex
ฝัง
- เผยแพร่เมื่อ 29 พ.ย. 2020
- Celebrex is a nonsteroidal anti-inflammatory drug related to aspirin, ibuprofen and naproxen. Celebrex received its patent in 1953, gained FDA marketing approval in 1999 and became available as the generic celecoxib in 2014. More than 7 million prescriptions are written for the drug each year.
Generally Celebrex is reserved for arthritis - osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis and ankylosing spondylitis. Approval also includes treating acute pain and dysmenorrhea related to the menses.
A newly released oral solution received FDA approval but only for acute migraine headache. The medicine performs only modestly better than placebo for migraines.
Recent investigations suggest combining Celebrex with a SSRI may benefit a select population with depression and if added to a mood stabilizer might lead to improvement in bipolar disorder.
Individuals allergic to sulfonamides should not receive Celebrex. A history of asthma worsened by aspirin also excludes Celebrex. After coronary artery bypass surgery, Celebrex appears to increase the risk of repeat coronary events.
Celebrex principally targets the COX 2 enzyme while other NSAIDS and aspirin reduce activity of both the COX 1 and COX 2 enzymes. Theoretically avoidance of COX 1 inhibition should reduce unwanted adverse reactions including intestinal bleeding and cardiovascular thrombotic events. In practice the differential while present remains anything but certain.
As a result, individuals should take the lowest dose for the shortest period of time in order to reduce the side effect profile. During the third trimester of pregnancy the drug must be avoided. In the first stages of pregnancy animal develop heart defects, skeletal malformations and stillbirth.
For pain relief, most of the NSAIDS appear about equal.
Thank you doctor. You are absolutely thorough with your lectures. This is gold.
Thank you, for your seemingly endless wealth of information. Your presenting skills are top notch!
Be well, take care.
Man, this drug is a COX-2 selective inhibitor which basically means an NSAID without the gastrointestinal issues!
I could listen to you all day! I really wish you were my doctor! You are on that level that I appreciate, and also trust, and literally understands risk ratios, and underlying conditions. I'm a paradoxical type, it's terrible, I suffer much because of it. But man I would love to pick your brain, I would enjoy hearing some lectures from you.
This great human being died in a car accident a few years back, may he rest in peace.
thank u so much doc ken landow
I’m 73 and have been on Celebrex 200mg daily for more than two decades. For me, it’s ability to repress inflammation is unrivaled. I’ve been taken off Celebrex due to the claim that is raises risks for internal bleeding when it’s necessary to be on blood thinners, e.g. for DVT. Maybe so. However, without Celebrex I have little quality of life.
Thank you very much
Doctor, can you please make a video on meloxicam. Also one on psoriatic arthritis. Thank you!
Dear Dr. Landow. Please make a video on CAR-T immunotherapy & another one on Oncolytic viruses Imlygic (TVEC).
Thank you Doctor
@wellnowdoctor Please make a video on CAR-T immunotherapy and another video on oncolytic viruses (TVEC or Imlygic)
i had a bleeding ulcer while taking Voltaren. Developed canker sores after taking ibuprofen every time. Swithed to Celebrex.
What about Arcoxia,from Merck&Co?Thank you!
Could you cover agomelatine?
4mmc - mephedrone , doc . can you cover it?
Do one on Strattera! :)
I'm prescribed 200mg celebrex tablets twice a day I took 2 tablets . I experience severe heartburn. I stoped dose . Should be worried and contact my doctor
you have to give some medications time for your body to adjust.That was a waste of time smh
👏👏
&
It is or it isn't back and forth back and forth back and fourth that's why I don't like touchy-feely drugs
The books are in perfect focus I could read them from here.
Fire your video person.
In other words, don't take Celebrex.
No kidding 😳
Life is about trade-offs of risks. I don’t believe this doctor would agree. For some people’ there’s simply not any good alternatives.
If that’s the case don’t take no drugs not even vitamins 🥹
From these stories the medical industry seems rather corrupted
BIGTIME 😳WOW
Just look at how covid was handled.
does it make u fill nice and fluffy
I am a human being. You have swallowed a couple of dictionaries. We are not doctors. Please use a kind of language we understand. It seems to me you learnt everything by heart.
🤔
He obviously knows his stuff without reading his spiel. I find that rather reassuring. He is a true encyclopedia of medical knowledge. That's even more reassuring. He covers a lot of ground in little time. That's where ADHD listeners might have a bit of trouble following him. No commercials every two minutes to interrupt the thinking thread. Immensely refreshing!
Pls doctor, it's my spine with serious pain in lower back of my left hand ,pls doctor prescribed celebre pls can l use . The pain started one and half months now.
Sorry upper back shoulder not the lower back .pls
Do research. Not everyone is going to adapt to your needs.
Sounds like a horrible drug
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