First year Medical student here, thank you for saving my life with this video! My med school Biochem lecturer is so bad, you literally just saved my life. Watched all 3 of your carbohydrate metabolism videos (Glycolysis, TCA/Krebs/Citric Acid cycle, Electron Transport Chain) and made literal transcripts of everything you said, I actually genuinely understand how carbohydrate metabolism goes from a simple carbohydrate (glucose) into 36 ATP!! THANK YOU SO MUCH! I didn't even know how many ATP either I learnt everything from scratch for Med school Biochem all from your videos alone. Honestly you sir are an absolute life saver and deserve an international award. Love from Dundee school of Medicine, Scotland, the United Kingdom!!
How about pre-med? I am pre-Med and I'm learning all this now before entering the university.... isn't it a bit late to just learn them in the university?😮
@@athenaaminimdno acutely in uni we take the same subjects we had take it in high school again but with little new informations. Im taking about the first common year
Im failing in med school right now because the professor does not explain things to me in a way I understand and I just want to say, YOU SAVE ME. I am so thankful! I just hope I can pull my grades up now that I found you!!!
May God bless you! I can't understand a lot from my lectures- I don't know why- so I just watch your videos and I feel like I can conquer the world. Thank you so much.
I am legit crying rn. My biochem final is in half an hour and I just now found this video...You are so helpful! I am a visual person and my professor is very much so not a visual person.
I'm a year 1 med student and I had this taught to me 4 times across both this year and Highschool but your video is the first thing to have me actually understand it instead of memorizing reactants and products. You're awesome
1 NADH creates 2.5 ATP. 1 FADH2 creates 1.5 ATP. 4 protons are required to generate 1 ATP. NADH releases 10 protons that are pumped into the inner mitochondrial space. Therefore, 10/4 = 2.5. FADH2 releases 6 protons. Therefore, 6/4 = 1.5.
@@iyedbouazdia3594 I think there’s two common ways of calculating. His is an older way. A more common way accounts for inefficiencies in the system and is a more realistic number. MCAT prep books use the 2.5 and 1.5 numbers just fyi
I'm usually not the type of person to write comments on youtube videos, but you guys saved my Biochem course during this pandemic (23.11.2020). Cause the professor just talks unamused into the microphone and its unbearable. But what you taught me in a couple of videos was great, easy to follow, interesting and super useful! So please please continue doing what you do!
This Man can really reach to the deepest understanding, When you watch His lectures,you will even be wanting abscond yourself from Other lectures at the University🌹🌹
I love this guy! He cleverly explains in a way that holds attention and is CLEAR to understand! I am so glad watched this vid! This is how teaching should be! Thanks Ninja Nerd!
How is it that you I'm learning more from your videos than any biology teacher/ professor I've ever taken? I love ninja nerd science!!!!! Thank you!!!!
Last three days I looked so many videos for ETC but couldn’t understand. You are the one who made me cry how well I retained this hard concept so easily. I cannot thank you enough. All the biochemistry book are failures in front of you.
I am a Ph.D. student in biochemistry and molecular biology. I've done many studies, but on here I've learned how we make the water inside the mitochondria. Thank you very much...
Thank you so much for all of these videos, I have a biochem exam in med school coming up and this is helping me immensely. Just as good as several of our seasoned PhD lecturers, if not better!
My favorite part was the half-way recap that starts at 14:59. If you were an iPad you would be a Pro iPad because you are so professional about the way you teach.
I just love your videos. I am medical student. Our text book is very complicated. When I find your videos on the topic my eyes become lighten:) . That is what we say in Azerbaijan. Means I find hope😊
hi zach.love your videos..small clarification..one nadh produces 2.5 atp , Bec 10 protons are pumped out of the matrix via nadh vs four protons pumped in to make one atp and hence 10/4 is 2.5. similarly for fadh2..it's 6 protons pumped out for 4 protons coming in to make one atp and hence 6/4 or 1.5 atp. 4 protons coming in make one atp. thanks a lot for the videos.they are amazing.
Zach was teaching a textbook accepted version of 38 ATP's. Have heard the same in Khan academy videos as well. Honestly I don't know why there r different versions.
I have no words how to express gratitude! I just started A&P and the P part of is very confusing to me. After I spent two hrs reading and trying to understand one page and did not succeed, I watched your 30 min video and I’ve got it now! THANK YOU 🙏
A genius! Thank u so much 'cause I'm literally studying for thi Biochemistry exam I've in 1 week and this video just help me to get some closure w/ the brunch of doubts I had
For every NADH that enters oxidative phosphorylation, 10 protons are being pumped out, and for every four protons that enters ATP Synthase, one ATP is produced. So you will get to realise we will produce 2.5 ATP for one molecule of NADH and 1.5 for FADH
but yo freal at the end of each video before the fade out just give us a 3 seconds screenshot of the whole board without you in the shot just so if I wanna pause and go over the stuff with myself then I can. no offence to you lol, its just that I find myself at the end looking for a shot where I can see most of the board. thx mydude.
I really love and appreciate every video you make it helps me at everything since I can't stand biochemistry usually but with your videos I don't just understand it I actually enjoy learning about it even more. I just wanted to ask a question, I'm studying at a university right now and when they talk about ATP result from NADH and FADH they don't say 3 and 2 they actually say 2.5 ATP and 1.5 ATP respectively, and I just checked the internet to make sure and it's actually right so is there a reason 0.5 of ATP gets lost or what happens here. Again thank you
I've always learned that complex 1 and complex 3 translocates 4 H+ across the membrane, and complex 4 translocates 2 H+. Which is a total of 10 H+ from a NADH. To produce 1 ATP from ADP + Pi is needed a gradient of 3 H+, however you also need to translocate the substrates (ADP+Pi) from the intermembranous space to the matrix. Translocating 1 ADP+Pi "costs" 1 H+ gradient. So the production of 1 ATP costs a H+ gradient of 4. As previously stated NADH translocates a total of 10 H+ across the membrane. 10 H+ / 4 = 2,5 ATP produced pr. NADH. FADH is only producing 1,5 ATP because FADH donates the electrons to complex 2, and not complex 1, thus only generating a H+ gradient of 6. 6 H+ / 4 = 1,5 ATP produced pr. FADH.
Thank you for the explanation AH. Interesting.. I wonder why there is a difference, I know Zach explained the 'textbook' version, I've heard the textbook version of 38 ATPs a few times now and there's a different version being mentioned as well which ends up with 32 ATPs, the one you were taught.. I do wonder why there's the 2 different versions floating around both being acceptable! @@AH-bu2iw
I love this channel! In my country, the university that I'm studying in it, has high level,but this channel is so much better! I just half one question, I read that Upon entering the NADH electron into complex 1, four protons are released and finally 10 out of 4 protein complexes. As a result, two and a half molecules of ATP are produced for one molecule of NADH. Can you tell me how?
To get a question answered, you could join our Discord server! (It's Free!) There are a lot of Ninja Nerd community members who enjoy learning together! - TG
Amazing teaching and very helpful just wish that at the end of each video you could move away a bit from the board so we can screenshot it or put a photo of the final board at the end of the video
This man has taught me more in 2 hours than my prof has for this semester
I love this guy he teaches good.
+1
For reall! Ninja nerd is the GOAT
Exactly 😂
Yea that's damn ryt bruhh
First year Medical student here, thank you for saving my life with this video! My med school Biochem lecturer is so bad, you literally just saved my life. Watched all 3 of your carbohydrate metabolism videos (Glycolysis, TCA/Krebs/Citric Acid cycle, Electron Transport Chain) and made literal transcripts of everything you said, I actually genuinely understand how carbohydrate metabolism goes from a simple carbohydrate (glucose) into 36 ATP!! THANK YOU SO MUCH! I didn't even know how many ATP either I learnt everything from scratch for Med school Biochem all from your videos alone. Honestly you sir are an absolute life saver and deserve an international award. Love from Dundee school of Medicine, Scotland, the United Kingdom!!
How about pre-med? I am pre-Med and I'm learning all this now before entering the university.... isn't it a bit late to just learn them in the university?😮
@@athenaaminimdno acutely in uni we take the same subjects we had take it in high school again but with little new informations. Im taking about the first common year
How did you pass the mcat without learning metabolism?
You're practically saving my academic career at this point, thank you 😊
Samantha x Mine too. 😬
OUR academic career
no word to say
this man deserves an Oscar more than anyone else 🥺❤
Such a great teacher!!!
Im failing in med school right now because the professor does not explain things to me in a way I understand and I just want to say, YOU SAVE ME. I am so thankful! I just hope I can pull my grades up now that I found you!!!
this is the first time i have ever actually understood the electron transport chain. in like, years. you make it seem so simple. thank you SO MUCH
Really 💓💓💓
I wish you were my professor, you actually teach and explain it in such layman terms for my newbie brain to understand. Saved me!
May God bless you! I can't understand a lot from my lectures- I don't know why- so I just watch your videos and I feel like I can conquer the world. Thank you so much.
I am legit crying rn. My biochem final is in half an hour and I just now found this video...You are so helpful! I am a visual person and my professor is very much so not a visual person.
My biochem final is tomorrow :')
some professors don’t understand what being a visual person is sometimes…
How did it go?
I'm a year 1 med student and I had this taught to me 4 times across both this year and Highschool but your video is the first thing to have me actually understand it instead of memorizing reactants and products. You're awesome
1 NADH creates 2.5 ATP. 1 FADH2 creates 1.5 ATP.
4 protons are required to generate 1 ATP.
NADH releases 10 protons that are pumped into the inner mitochondrial space. Therefore, 10/4 = 2.5.
FADH2 releases 6 protons. Therefore, 6/4 = 1.5.
💕
Why didn't he mention that then?
@@iyedbouazdia3594 I think there’s two common ways of calculating. His is an older way. A more common way accounts for inefficiencies in the system and is a more realistic number. MCAT prep books use the 2.5 and 1.5 numbers just fyi
@@ZantherStone thanks good to know
Sorry is it really 6NADH FOR TCA or 3NADH
I'm usually not the type of person to write comments on youtube videos, but you guys saved my Biochem course during this pandemic (23.11.2020). Cause the professor just talks unamused into the microphone and its unbearable. But what you taught me in a couple of videos was great, easy to follow, interesting and super useful!
So please please continue doing what you do!
You're the best teacher ever, I could understand every single thing mentioned in this video!
Why does this feel like a whole different biochemistry from what they told us in university? BECAUSE IM ACTUALLY UNDERSTANDING THIS
yah me too. in uni they will be saying random names and here we get names that we understand
Your delivery of the material is excellent! You teach in a way which helps break down big concepts into digestible pieces. Thank you!
Bro i honestly owe so much to you. One day, the least i can do, is buy you a beer my man. THANK YOU!!
It's the best video I've seen on ETC. Everything about ETC became clear to me.
THIS IS THE SIMPLEST VIDEO FOR THIS CHAPTER EVER. Thank you ninja nerds.
This Man can really reach to the deepest understanding,
When you watch His lectures,you will even be wanting abscond yourself from Other lectures at the University🌹🌹
Gratitude to you Ninja Nerd 🤓. I'm definitely getting an A+ in Biochemistry for watching your videos and learning from you.
I love this guy! He cleverly explains in a way that holds attention and is CLEAR to understand! I am so glad watched this vid! This is how teaching should be! Thanks Ninja Nerd!
You know, I DO OWE YOU A KIDNEY FOR THIS. YOU SAVED MY MEDICAL TEST. Thank you professor ninja.
Ive gone trough ETC in my book for 2hours and got nothing but after watching this video for 30 mins even remember it much better
The greatest thing that has happened to me in my first year of Med school.
Your videos helped me to clear DBT-JRF, an Indian Junior research fellowship exam. Thank you so much!
That's my dream! Congratulations. I am now in my second year of studying Biotechnology in NIT Calicut. Hope I can also do that.
That's my dream! Congratulations. I am now in my second year of studying Biotechnology in NIT Calicut. Hope I can also do that.
Well Explained Sir ❤
How is it that you I'm learning more from your videos than any biology teacher/ professor I've ever taken? I love ninja nerd science!!!!! Thank you!!!!
this is my fav biochem revision channel thank you so much for your efforts
You're changing peoples lives for the better with your videos. Thank you!
🙏🏽Thanks for all this, I recommend to take a photo to the board and put it in description box , it will absolutely help♥️
Last three days I looked so many videos for ETC but couldn’t understand. You are the one who made me cry how well I retained this hard concept so easily. I cannot thank you enough. All the biochemistry book are failures in front of you.
So far watching this biochemistry playlist in one day has taught me more than my entire semester has.
This is pure gold. Perfect explanation that is scientifically correct and easy to follow. Thank you so much.
I am a Ph.D. student in biochemistry and molecular biology. I've done many studies, but on here I've learned how we make the water inside the mitochondria. Thank you very much...
You are simply awesome...Such wonderful explanation. We must nominate him for Nobel prize for "Service to humanity" :)
Thank you sooo much 💜 I really enjoyed the lecture and understood everything.... You're a LIFESAVER!
Thank you so much for all of these videos, I have a biochem exam in med school coming up and this is helping me immensely. Just as good as several of our seasoned PhD lecturers, if not better!
Struggled for 2 days.. Couldn't understand anything about ETC.. Then saw your video.. Now fell in love with ETC..
The only person who makes medicinal chemistry so easy
flabbergasted at this video, perfect overview of ETC, easily understood with such clear explanations! so glad I stumbled upon this channel!
2nd year pharmacy student here, appreciate this man💕
carbohydrate metabolism has been kicking my butt in MCAT practice so thank you for these awesome visualizations to see it stepwise
this man is carrying my grade this semester
Currently doing my MBChB program and I always run to this whenever I don't understand a thing..Thank You for simplifying things
2023 joke update- the complexes here are really saying "double it and give it to the next person"
HAHAHAHAHA GOD I LOVE NERDY JOKES
HAHAHHAHAHAHA
From this diagram I was able to calculate the total gain of ATP from one molecule of glucose under aerobic conditions. Sir, thank you.
So many amazing and clever teaching techniques being displayed in this lesson. Bravo!
Keep pushing students comprehension forward❤
cant have words to describe your teaching skills u just make things soooo easy to grasp that it's awesome....
These days I even pray for you to live longer,you're a life saver..Thank You for sharing such knowledge with us Ninja Nerd..
Dios mío! eres un GENIO!!! You´re a GENIUS!! Neither of my professors explained to me chemistry as you do it !! thanks a lot!! OOO from Ecuador
You are a gift from the universe to science
Awesome diagrams, and perfect, easier to understand lectures!! Thank you so much as always!!
i want to be a teacher like you who can taught each and everything so smartly
Best lecturer ever.im speechless to describe it
YOU UNDERSTOOD THE ASSIGNMENT!! thanks for the lesson!!
obsessed with this channel now omg
My favorite part was the half-way recap that starts at 14:59. If you were an iPad you would be a Pro iPad because you are so professional about the way you teach.
In our lecture that was very complicated but with you that become extremely ease thank you 🙏
I can’t believe I found an ETC explanation video actually interesting. You’re an incredible teacher, thank you so much
this man saving my life and future.
Great work☺️
Thank you for simplifying what seemed taugh
I just love your videos. I am medical student. Our text book is very complicated. When I find your videos on the topic my eyes become lighten:) . That is what we say in Azerbaijan. Means I find hope😊
hi zach.love your videos..small clarification..one nadh produces 2.5 atp , Bec 10 protons are pumped out of the matrix via nadh vs four protons pumped in to make one atp and hence 10/4 is 2.5.
similarly for fadh2..it's 6 protons pumped out for 4 protons coming in to make one atp and hence 6/4 or 1.5 atp.
4 protons coming in make one atp.
thanks a lot for the videos.they are amazing.
Zach was teaching a textbook accepted version of 38 ATP's. Have heard the same in Khan academy videos as well. Honestly I don't know why there r different versions.
But it should be 32atp
Matale shuttle and glycerol 3 p shuttle .....yeah please
@@flowerpetal6193 this was updated in the textbooks in the year 2018 - 2019… his video is older I guess…?
Its absurd how much better he is than high level professors at big universities
I have no words for this guy.
It's very difficult but bro you're talented to explain and make things seems simple
I don't even need my tutor anymore ! Thank you so much!
u are saving me from many exams.....thank u sir..
I have no words how to express gratitude! I just started A&P and the P part of is very confusing to me. After I spent two hrs reading and trying to understand one page and did not succeed, I watched your 30 min video and I’ve got it now! THANK YOU 🙏
youve explained my entire degree thank you
as a first year med student, thank you for saving my life
This man is great! Wish you all the happiness of the world
I love you from the bottom of my heart
A genius! Thank u so much 'cause I'm literally studying for thi Biochemistry exam I've in 1 week and this video just help me to get some closure w/ the brunch of doubts I had
Great overview , made it easier to link the steps
Thank you very much for your lectures. You are doing a great job by the sharing your knowledge with the people all over the world.
Woow!!!!this is incredible..what seems to stress me out is now fixed..thanks to Ninja nerd 😊
He has giant database of knowledge...
He has very great teaching skills along with strong fundamental and advance database..
.
Salute sir...
it's 2 hours before my cellular biochemistry final and you are a saviour
+Steven Wade I don't know about Savior! But I am thankful that we were able to help! Thank you so much for your kind words and best of luck.
i like your video even before watching it , i know the only man who can put biochemistry into my mind
I think people who make educational videos should make more money. They sometimes explain things so much better than my professors. Great video!
You actually release my academic pressure. Great explanation. Good luck. Keep it up
Completed my whole semester topics in 3 hrs video for 2 courses 🔥🔥
For every NADH that enters oxidative phosphorylation, 10 protons are being pumped out, and for every four protons that enters ATP Synthase, one ATP is produced. So you will get to realise we will produce 2.5 ATP for one molecule of NADH and 1.5 for FADH
Absolutely superb series. University level presentation. 5 Stars
You are the real MVP Ninja Nerd.
Thank you so much!
Ninja Nerd, you're the best!
You are the reason i have started learning bio and loving it.. 🥺
I've watched so many videos of electron transport and this one was the most helpful. Thank you!
but yo freal at the end of each video before the fade out just give us a 3 seconds screenshot of the whole board without you in the shot just so if I wanna pause and go over the stuff with myself then I can. no offence to you lol, its just that I find myself at the end looking for a shot where I can see most of the board. thx mydude.
I Agree😍
I agree 100%
You can draw/write it yourself
Luka Jovičić
This way is much better
Unless you don’t have time
If anyone is interested they offer full pictures of their board for each session to patron supporters. It's worth supporting them if you're capable.
I really love and appreciate every video you make it helps me at everything since I can't stand biochemistry usually but with your videos I don't just understand it I actually enjoy learning about it even more. I just wanted to ask a question, I'm studying at a university right now and when they talk about ATP result from NADH and FADH they don't say 3 and 2 they actually say 2.5 ATP and 1.5 ATP respectively, and I just checked the internet to make sure and it's actually right so is there a reason 0.5 of ATP gets lost or what happens here. Again thank you
I've always learned that complex 1 and complex 3 translocates 4 H+ across the membrane, and complex 4 translocates 2 H+. Which is a total of 10 H+ from a NADH. To produce 1 ATP from ADP + Pi is needed a gradient of 3 H+, however you also need to translocate the substrates (ADP+Pi) from the intermembranous space to the matrix. Translocating 1 ADP+Pi "costs" 1 H+ gradient. So the production of 1 ATP costs a H+ gradient of 4.
As previously stated NADH translocates a total of 10 H+ across the membrane.
10 H+ / 4 = 2,5 ATP produced pr. NADH.
FADH is only producing 1,5 ATP because FADH donates the electrons to complex 2, and not complex 1, thus only generating a H+ gradient of 6.
6 H+ / 4 = 1,5 ATP produced pr. FADH.
From what I know it is because of the result when u balance equations... you have to balance both sides thus the .5 ....it’s weird I know lol
Thank you for the explanation AH. Interesting.. I wonder why there is a difference, I know Zach explained the 'textbook' version, I've heard the textbook version of 38 ATPs a few times now and there's a different version being mentioned as well which ends up with 32 ATPs, the one you were taught.. I do wonder why there's the 2 different versions floating around both being acceptable!
@@AH-bu2iw
@@AH-bu2iw Well done AH, that's how i learned it as well, thanks for adding that info much appreciated!
@@AH-bu2iw thank u👍🏻👏🏻
Thanks from 2024 - 2nd year med student ... you 're agreat prof❤❤
Thank You Zach! Thank You Rob! Thank You Kristen! These lectures are definitely awesome. Thank You Sincerely
They have updated the number of ATP for NADH and FADH, from 3 and 2 to 2.5 and 1.5
i can't even thank you enough for your efforts
I love this channel! In my country, the university that I'm studying in it, has high level,but this channel is so much better!
I just half one question, I read that Upon entering the NADH electron into complex 1, four protons are released and finally 10 out of 4 protein complexes. As a result, two and a half molecules of ATP are produced for one molecule of NADH. Can you tell me how?
To get a question answered, you could join our Discord server! (It's Free!) There are a lot of Ninja Nerd community members who enjoy learning together! - TG
You are the GOAT fr, keep it up ninja nerd This is amazing!
bruh your my new lecturer during corona lockdown
Amazing teaching and very helpful just wish that at the end of each video you could move away a bit from the board so we can screenshot it or put a photo of the final board at the end of the video
Thank you for existing 🙇