PHARMACOKINETICS; Metabolism & Excretion by Professor Fink
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- เผยแพร่เมื่อ 1 ต.ค. 2024
- This is Part 2 of Pharmacokinetics by Professor Fink. In this Video Lecture, Professor Fink explains the Metabolism (Biotransformation) and Excretion of Drugs in the Human Body. In the Metabolism discussion, reference is made to the more water-soluble metabolite, Phase 1 Reactions (hydrolysis, oxidation, reduction & deamination), Phase 2 Reactions (conjugation to glucuronic acid), factors that affect the rate of metabolism and the 1/2-life of the active drug in the bloodstream.
Professor Fink also explains Excretion of both the active form of a drug and its metabolite by the Kidneys (including glomerular filtration, tubular reabsorption & tubular secretion). Reference is also made to Biliary Secretion, Exhalation by the Lungs and other routes of Excretion.
Check-out professor fink's web-site or additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased at: wlac.redshelf....
The “hard copy” of the Pharmacology Lecture Outline CAN BE purchased. Please e-mail Mr. Nilhson Zelaya, in charge of sales at the WLAC Bookstore. His e-mail is: ZelayaN@wlac.edu
He can tell you the cost.
I get a fright every time you slap your hands together lol. You are a great lecturer, I don't even get tired when watching your videos. Thank you for sharing your gift of teaching and your knowledge of Pharmacology with us. You are phenomenal. God bless you. Love from a Med student in South Africa.
+Nicole Solomon the slapping of the hands.... gets me everytime.
Same hahaha
Don't be stressed 😂
Don't be stressed 😂
You sir must sometimes look in the mirror and be like "wow am i great or what". You are a great lecturer, absolutely the best. From a pharmacy student in South Africa
Dear Prof. Fink. Excellent lecture. I really like the way you explain the concept in a deep and simple manner. Thanks for sharing your videos. It is of great benefit to me and students as well.
I'm a British student to become a nurse prescriber and your lectures are better than my universities. I haven't got a clue what they're going on about but using your videos alongside is helping things fall into place 🙏
I've never understood Pharama till I watched your videos! I wish I had these lectures when I was at school more than 10 years ago!
You are a true legend Sir. I wish all my teachers were like you.
Felt this
Your way of simplifying complex topics is the best . 🔥🔥🔥
You are gift to medicine!I hope my lecturer sees this and notices the difference between lecturing and teaching
you are a very good professor and your videos are very helpful for us in medical university.. thank you so much, we solute you all the way from Namibia. blessings!!
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased at: wlac.redshelf.com/
The “hard copy” of the Pharmacology Lecture Outline CAN BE purchased. Please e-mail Mr. Nilhson Zelaya, in charge of sales at the WLAC Bookstore. His e-mail is: ZelayaN@wlac.edu
He can tell you the cost.
Thanks Prof. Fink - you are a master of your trade.
I am a Pharm D Student from Mumbai, India. Loved your way of teaching!! You are truly a great lecturer!!! Looking forward for more videos
How’s the Pharm D going?
Thank you so much for teaching Pharmacology so well Dr. Fink. I can understand it better than when I was in nursing school. Now that I’m in NP school your videos are so helpful to help me to understand concepts better than the textbook or on line classes. Thank you again!
You are an inspiration, Sir. I am an Indian student in final semester of Masters in life science. You have contributed so much to feed my curiosity about human body and its functioning. Its because of your lectures I have not just aced physiology tests but has also had the most conceptual and unequivocal understanding of the subject. Keep doing more of these! Much respect, Sir :)
PS: Would be great to have some lectures on some detection techniques like PET, MRI, ECGetc
Wow!! You’re such an extraordinary lecturer! Others should learn how to teach from you. Most of my lecturers don’t know how to teach. They simply read from their slides.
2019 first semester nursing program thankfull for your lectures
THANKS for u lectures step by step..an instructors like u i needed at Cuny./NYC
may God continue to inspire you for this mission here on earth, i am writing from cameroon a clinical psychologist and a consultant. my name FOKWA DESMOND
Thank you for your kind words. I wish you Much Success!
I love just having your videos in the back round of me drawing. I still understand everything you are talking about and it’s so fun to learn
What a brilliant lecture! Thank You a Lot. It can easily understood
This is a really GREAT video- you have explained these concepts reallly well, even dummies can understand this stuff! Hhahah
every lecturer should be like you-keeeeep it uppp!
THANK U
Thank you so much Professor Fink! I really enjoy these video lectures.
Dr. Fink you are awesome! I love your videos.
This is one of the best videos I've watched so far that has been really helpful you truly are a great teacher 🙌
please stop slapping I was already paying attention now my ears are just bleeding
Your videos helped me with anatomy and physiology. I am now in nursing school and watching your videos for pharmacology. You are an amazing teacher. You really help me learn! Thank you ❤️
Thank you so much Sir! I am from Pakistan, when I prepared for FPGEE and watched your videos and I passed, now I am preparing for NAPLEX, again I am watching your videos and I know I am gonna pass this too. Every time I need to review or refresh my concepts and I watched your video. You are the best teacher and you explain it so well that I become interested in learning more 🤩
Love the *claps* haha
Dear sir, I got confused when you said Digitoxin slows heart rate..Doesn't it increases cardiac contractility (increase/positive ionotropy) and hence increase heart rate?
Digitoxin slows down the Heart Rate ("negative chronotropic effect"), but increases Stroke Volume ("positive ionotropic effect". In contrast, epinephrine has BOTH a positive chronotropic and positive ionotropic effect.
Thanks so much for your prompt clarification.
wow, you really made it so easier to understand. God bless you.
I like the man like something.. wow
Thanks Fink for such a brilliant lecture. I'm not sure that APAP is eliminate through the biliary route!
That is a bit of old info though. I reckon APAP is primarily secreted through the renal route 90%.
You are an amazing professor. Will definitely go through all your other videos and pass on the knowledge. Thank you, thank you and thank you for your passion and for all the pharmacology (FUN!) videos. Looking forward to more...subscribed*
ِطگگگ
your are amazing teacher
Thank you Prof Fink! Greetings from Singapore :)
You are great and I never fully understand these concepts now I easily understood all those thanks for uploading on you tube and God bless you keep postings the vds its very informative
You are awesome
Is this UCLA? Do you ever cover Lactulose??? That would be a great med in this context.
very nice sir
Wonder if it's possible to join one of your lectures as an exchange student
woooooowwwwwwww. How can I say the extent I got shocked by your teaching. Fantasticcccc. wooow
brilliant
V wonderfull teacher !! Keep it up .
God bless you Sir !
Is the half time of your example 2 hours. Or 4 hours.
2 hours
Great video. Keep up the good work. God bless you😊
thank you sir. love from south America
What an incredible teacher - thank you!
I love professor Fink videos. He is so articulate and detailed. I use his channel for research purposes.
How do I get in touch with you?
the best teaching effort contributed by u
Thanku so much professor...I'm a b pharm student ( 2nd year) ....n ur lectures r very much helpful..n I also do enjoy watching these lectures.....
.....love from Kashmir...
thank you sir 😃 all my respect
you are above the stars sir ji...😄
Professor, could you please explain why do we have to take prednisolone during the morning?
Prednisolone & other (gluco-) corticosteroids are taken in the morning to mimic the natural release of cortisol from the Adrenal Gland upon waking in the morning.
Another thing that will effect the rate of metabolism is drug-drug interactions, e.g. Phenytoin will induce more CYP450 enzymes; this must be considered when administering another drug as it will be metabolised at a higher rate so a higher dose may be required to compensate for this.
Thank you Professor !!!
Thank you so much for sharing your tremendous knowledge with us!! Your explanation of pharmacology has helped me understand this daunting material!! I truly appreciate it!! And I got a great mark on my quiz!!
thanks for the video
Question- if codeine is excreted through the hepatic process, how dose it show up on a urinalysis?
Its excreted through the urine
www.medicines.org.uk/emc/product/11268/smpc
Thank you💕
Thank you!
nice class!
I am at elementary level
Excretion 24:30
Wait why did it end
Sir I have doubts if drug is taken firstly it will goes to liver and where it metabolites and excreted through urin , how the drugs goes to active site sir plz give reply sir
As a drug is absorbed from the digestive tract into the bloodstream , it is carried to the Liver. There in the Liver, some of the drug will be metabolized (altered) -- let's say 25%. So, what leaves the Liver and then flows into the Inferior Vena Cava are the Active form of the Drug (75%) and the Metabolized form of the Drug (25%). The Active form of the Drug can still act on the active (Receptor) Sites. See: www.ncbi.nlm.nih.gov/pubmed/6362950
Thank you professor Fink
it was awesome sir. but I have a question. u said all inactive drugs or metabolites and 1/2 of active, lipid soluble drugs remain in the kidney tubule. other 1/2 of active, lipid soluble drugs are re-absorbed from the tubule. my question is why only half of active drugs are re-absorbed? why not all of them are re-absorbed? as they are active and lipid soluble that can easily cross cell membrane.
thank u sir...
Diffusion is when a chemical flows from an area of higher to lower concentration, and will tend to distribute evenly. The lipid-soluble form of the drug simply follows this diffusion pattern, distributing roughly evenly between the renal tubule and the bloodstream.
Thank you sir.... :-)
Tausend Dank, Herr Fink!
you used "dank" as an adjective, i prescribe you 5 episodes of loveline with doctor drew circa 2003.
Thanks a bunch doc
thank you sir
You are awesome
thanks sir.
love u sir.....
I want these lectures professor , is there a book or pdf ?
You can purchase the Pharmacology Lecture Outline for $20 at: wlac.redshelf.com/ This is a 100% downloadable PDF that is 100% printable.
@@professorfink thank you professor, i will do soon💜 , it’s for pharmacy student isn’t it?
@@msasyhero7559 The lectures were given to Allied Health students (Nursing, Dental Hygiene, Physical Therapy, etc.)
@@professorfink thank you professor 🌼
I am a nursing student, just wanted to thank you for all your videos. They really help
YOU ARE AMAZING.
You are a greatest professor in the world
I had some question you said the the metabolism is changing the drug to water soluble that it will be difficult to enter the cell membrane but their is some drugs hepatic excreted and reabsorbed by gut and carry to the kidney how it's across the intestine membrane while it's water soluble
they are most likely lipid soluble than water soluble....