Thank you! I am taking Pharmacology and that makes a lot more sense. My professor only talked about Phase 2 Metabolism for like 20 seconds, (possibly because it is an introduction to Pharmacology class), but I still did not understand what Phase II Conjugation was all about. This explains it nicely! :)
why can't all the university lecturers explain concepts like you? It would make our lives so much easier. I've listened to your video once and got the concept. Listened to my lecturers recording a tonne of times and still don't understand what he was talking about
What is absorption actually(interms of tablet taken orally),is it the process where drug gets absorbed from gut to hepatic portal system or the process where drug gets absorbed to the arterial circulation? If the process of drug getting absorbed to arterial circulation is the absorption,then Metabolism would occur before absorption,isn't it? So ADME is the wrong order? Could u plz explain it?
@@namonscreen You should listen well to the video. He just said that most drugs are metabolized by the liver or other organs. Absorption during his first video can be done orally, IV or via inhalation. You gotta see the whole picture. Goodluck!
Really easy to understand. Ty for the video. My pharma book explain the basic definition of first pass, none of the specifics, then keep mentioning p450 liver metabolism. I'm so mad they didn't ever explain what p450 does. Now these side effects of drugs, adverse effects, and pharmacokinetics makes a lot more sense. Good thing my final is tomorrow.
Thank you, this helps makes some sense to why my medication isn't being metabolized right. Its creating some issues in my life and the doctors act like they have no knowledge of this issue that is real and really takes place.
Absolutely fantastic descriptions. Thanks for finally making this stuff make sense, especially the cellular respiration cycles. Must be NSW, because i can understand you perfectly ... Thanks again, and Sign me up !
When you say "excreted" by the kidneys.. did you mean to say eliminated? Because excreted would imply that it was not used by the body, correct? Or did you purposefully mean to say excreted. My question essentially is this: have these examples been subject to biotransformation or no?
When you say elimination you mean the irreversible loss of the drug from the body by mean of metabolism(which form metabolites from the drug) and excretion (excreted by kidney or in bile), and yes the metabolism of exogenous compounds (drugs) called biotransformation.
Aspirin need to be changed to Salicylic acid. but after Phase I happened, will it not directly go to Phase II? How can salicylic acid come out of the liver before it goes to Phase II?
Thanks for you lesson. It is so difficult for me, to memorize the differents CYP Kategorie. I've to learn about medicines (Psychopharmaka) interaktion. I need some images to help me. Could you do a tutorial about that? Sorry for bad englisch.
Oxidation is most common and is RH(drug)O2(molecular oxygen),+ NADPH= ROH+NAD+ + H2O. P450 Cytochrome (heme-protein) Transfers an oxygen atom to the drug RH through the activation of molecular oxygen, introducing one oxygen atom to the drug and one molecule and reduction of the other to H2O. Hydrolysis is not common and happens in drugs like aspirin, which breaks down to salicylic acid and acetic acid. Salicylic acid is the active drug(it was an inactive prodrug aspirin)
Drugs like diazepam, Phenobarbital, chlorpromazine have aromatic rings(like benzene) and these will always be made more hydrophilic with addition of OH group. So oxidation you know from the struture 95% are oxidation reactions.
Doing my pharmacy tech course and this video explains it beautifully! Keep up the good work!
This stuff is gold. Do watch all of the adverts to keep these tutorials going.
A good human being always tries to make things easier for others.....great teacher!
Are alive now
Thank you! I am taking Pharmacology and that makes a lot more sense. My professor only talked about Phase 2 Metabolism for like 20 seconds, (possibly because it is an introduction to Pharmacology class), but I still did not understand what Phase II Conjugation was all about. This explains it nicely! :)
why can't all the university lecturers explain concepts like you? It would make our lives so much easier. I've listened to your video once and got the concept. Listened to my lecturers recording a tonne of times and still don't understand what he was talking about
If you use the handwritten tutorials website, every video is listed, and is sortable.
What is absorption actually(interms of tablet taken orally),is it the process where drug gets absorbed from gut to hepatic portal system or the process where drug gets absorbed to the arterial circulation? If the process of drug getting absorbed to arterial circulation is the absorption,then Metabolism would occur before absorption,isn't it? So ADME is the wrong order? Could u plz explain it?
@@namonscreen You should listen well to the video. He just said that most drugs are metabolized by the liver or other organs. Absorption during his first video can be done orally, IV or via inhalation.
You gotta see the whole picture. Goodluck!
You have made my academic medical career much easier. Hope one day I can pay you back for the good work!
are u a doctor now?
Really easy to understand. Ty for the video. My pharma book explain the basic definition of first pass, none of the specifics, then keep mentioning p450 liver metabolism. I'm so mad they didn't ever explain what p450 does. Now these side effects of drugs, adverse effects, and pharmacokinetics makes a lot more sense. Good thing my final is tomorrow.
are you the same guy that illustrated the ridiculously simple series? the handwriting and drawing style is unmistakable!
Love ya vids, has really helped in my first 2 semesters of nursing
this was so beautiful to watch
taking pharmacology and wow this is a lifesaver thank u so much
Doing my pharmacology CAT today and your videos have been super helpful. Thank you so much.💖
You are brilliant..Thanks so much. You have no idea how much this has helped me
Aspirin is hydrolysed by esterase enzymes not CYP enzymes.
yup, you are correct he is wrong in that particular example
Thank you, this helps makes some sense to why my medication isn't being metabolized right. Its creating some issues in my life and the doctors act like they have no knowledge of this issue that is real and really takes place.
Nice video! The hand written diagrams are easy to understand and pleasant to look at :)
Absolutely fantastic descriptions.
Thanks for finally making this stuff make sense, especially the cellular respiration cycles.
Must be NSW, because i can understand you perfectly ...
Thanks again, and
Sign me up !
Amazing! Nice quick lesson, and light to listen and understand. Simply Great!
Brilliant videos, thank you. I have finals at the start of January, really need your final pharmacokinetics video before then?! Merry Christmas.
Thanks..i hope u make playlists in ur channel in order to be easier for us to find what we are looking for.
thanks a lot you break down the complicated issues
Awesome, as always. My pharmacy class thanks you!
clarissa dade-esposito
Tell them how to make pentobarbital.
thank you. I will donate when I can!!! thank you. this was very helpful and easily brought across to me.
شرح رائع ، ربنا يكرمك و يفتحها عليك ويباركلك يا رب
Well explained 👍
such a great help. i'm waiting for your next video for Excretion. thanks! :)
Great tutorials. .lovely voice..thank u
thank you
its help me a lot
Great little tutorial, thanks!
I have a question…when the drug will exert its action? During distribution or metabolism?
your videos are great!
thsnk you very much, it helps me to get an A in my Bio,Test, thank you so much!!
Bio?
Thanks alot..... By ❤️... This help me alot... Thank u again
thank you its very helpful
"and I'll try and keep the organic chemistry to a minimum"
thank you.
When you say "excreted" by the kidneys.. did you mean to say eliminated? Because excreted would imply that it was not used by the body, correct? Or did you purposefully mean to say excreted. My question essentially is this: have these examples been subject to biotransformation or no?
When you say elimination you mean the irreversible loss of the drug from the body by mean of metabolism(which form metabolites from the drug) and excretion (excreted by kidney or in bile), and yes the metabolism of exogenous compounds (drugs) called biotransformation.
this is very helpful
Hi. I'm Maryam, a third year veterinary medical student.. I couldn't properly get what you said @0;23 ..in the lungs or ??????
very helpful, Thankyou.
Thank u u make me happy 😃
That was more chemistry than I would've liked
it was just awesome....
Aspirin need to be changed to Salicylic acid. but after Phase I happened, will it not directly go to Phase II? How can salicylic acid come out of the liver before it goes to Phase II?
Thank you so much
Gaurab achis?
Thank for this
CYP19A1 aromatizes testosterone into estrogen. How do I kill that action?
THANK YOU VERY MUCH
hi,does every drug actually go through phase 2 or are their some drugs that only go through phase 1 and that's it??
that was a cool video!
Thanks for you lesson.
It is so difficult for me, to memorize the differents CYP Kategorie. I've to learn about medicines (Psychopharmaka) interaktion. I need some images to help me. Could you do a tutorial about that?
Sorry for bad englisch.
Thanks a lot!!
amazing
Thankss a lot
Thanks a lot
Thanks
Thank u so much 😊
good lecture but more voice please (sorry for bad English)
*bad sorry for english
thanks.
Thank youuu
Hoorraaa P450 is finally understood
Wow. I would've never guessed most drugs are metabolised in the liver 😮 (04.12.2020) - DW Groove
thank's bro...
Niiiice!! Thank You
i have a qustion how do i know when hydrolysis or oxidation occure ??
Oxidation is most common and is RH(drug)O2(molecular oxygen),+ NADPH= ROH+NAD+ + H2O. P450 Cytochrome (heme-protein) Transfers an oxygen atom to the drug RH through the activation of molecular oxygen, introducing one oxygen atom to the drug and one molecule and reduction of the other to H2O. Hydrolysis is not common and happens in drugs like aspirin, which breaks down to salicylic acid and acetic acid. Salicylic acid is the active drug(it was an inactive prodrug aspirin)
Drugs like diazepam, Phenobarbital, chlorpromazine have aromatic rings(like benzene) and these will always be made more hydrophilic with addition of OH group. So oxidation you know from the struture 95% are oxidation reactions.
thanx 😁
amazing ! =]
I love you
thankssss
thank you (:
My word, the subtites are hilarious!
***** lol so true
great video but too in depth for nursing pharmacology
as an american, i never thought i could get bored listening to an english accent.
He's australian
pls dont paint a carboxylic acid group attached by its oxygen atom :D that's just grose!!!
Nice video! If I can make a suggestion, it would be better if you talk faster ;)
You can just adapt the video speed, smart ass
not with my smartphone genius
Alessio Grigolini watch it on a computer then
Go get Puffin Browser for smart phone or a youtube ad-app
bhak sale khud se speed badhale..
1980
podia traduzir
ASA is not a prodrug!
Yes it is...
*Hi, I came here because I smoke WEED :)*
First you might be going to jail for imposing false Drug results on innocent public
t h a n k y o u : ) !
Thanks
1980