PHARMACOKINETICS; Absorption & Distribution by Professor Fink
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- เผยแพร่เมื่อ 4 มิ.ย. 2013
- In this Video Lecture (Part 1) on Pharmacokinetics, Professor Fink describes the Absorption & Distribution of Drugs. The major factors affecting the systemic absorption of drugs are presented, including how pH affects the ionization of weak organic acids (like aspirin) & bases (like codeine & lidocaine), which in turn affects lipid-solubility.
In describing the Distribution of Drugs through the body, reference is made to sites of action (Receptor Sites, inactive (Acceptor) sites, binding to plasma proteins, circulating free drug, metabolites, the Blood Brain Barrier and the Redistribution of drugs.
Check-out professor fink's web-site for additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased at: wlac.redshelf.com/
The “hard copy” of the Pharmacology Lecture Outline CAN BE purchased. Please e-mail Mr. Nilhson Zelaya, in charge of sales at the WLAC Bookstore. His e-mail is: ZelayaN@wlac.edu
He can tell you the cost.
What a exemplary lecturer? His students are very lucky
You changed my perspective of pharmacology and I enjoy it better
I must meet you one day
You're a real genius , thank you so much for sharing your videos on youtube and letting other students across the world to get benefit and learn something !! God bless you !
Best of regards from Iraq !!
Thank you for your kind words, Soma. May God Bless YOU! -- professor fink
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I stupidly lost the password. I would love any tricks you can offer me!
@Brady Zion instablaster ;)
@Duncan Archer I really appreciate your reply. I found the site through google and I'm waiting for the hacking stuff atm.
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Thanks so much you really help me out :D
My lecturer bother herself reading the slides only ,thank you soooo much now its clear
THIS IS AMAZING, I HAVE NEVER SEEN A PROFESSOR SO EXCITED AND ENTHUSIASTIC ABOUT HIS TEACHINGS!!! so epic
thank you for explaining the topic in the easiest possible way. relating it to the real world use is very helpful too.God bless you!
Thank-you Prof. Fink.. you are a God amongst men!! your youtube student in Lebanon, PA
Professor fink.. Can you make a video of the entire phamacokinetics? Including some Calculations and covering the concepts of ADME??
I've watched your videos during my first, second and now third year of university! Chemistry, Embriology, Physiology etc. Thank you so much! Best wishes and a big hug from Brazil!
Dear Fabiane, Thank You for your kind words! My sincere BEST WISHES for your SUCCESS!!
Another Brazilian. Fabiane vc fez farmácia?
wow.. that's great sir .I learn alot .... you saved my 5 hours to read and understand the concept from book.... Thanks alot sir .... Allah bless you .Best of time from Pakistan.
Prof. thank you for sharing your lectures on you tube, you are a genius. I benefited immensely.
I think the words are not enough to describe how you are amaaaaaaaazing. Thaaaank you very much.
Thank you! Very nice presentation of pharmacokinetics! Salve to the soul of a nurse practitioner in training.
i always rewatch this video everytime i want to teach my student.bless you professor
I will never take a school day for granted if you are my professor. I'll never even think of absent even if I am sick. Haha. Your lectures are well explained. I wish I had this extensive lecture back then.
THK YOU PROF FINK. YOU ARE A BLESSING TO ME. GOD BLESS YOU.
seriously I was very worried about my pharma but ur lectures are a big relief , n a problem solver . god bless you and please keep continue ur work . lots of love from pakistan
thank you for sharing your lecture professor fink! it was very engaging and you managed to simplify some pretty difficult concepts! I am so glad i came across your lectures
best regards!
Bless you professor...thank you for sharing your knowledge...
THANK YOU Dr. Fink... You are great.
I am astonished you make it so clear and easy even explaining it detailed I'm so happy I founded your channel. GOD BLESS YOU PROFESSOR STAY GUCCI.
You are terrific! Thank you prof. Fink.
I never knew I would learn so much in a short time
Thank you Prof. THIS IS SO CLEAR AND HELPFUL :)
Awesome video. I actually UNDERSTAND the presented pharmacokinetics !!
You are one of of not the best of the best thank you so much for all your knowledge and helping us learn thank you 🙏!
Thank You for your kind words; I sincerely appreciate it! Best Wishes for your Success -- professor fink
Really amazing Doctor.... Now I'm getting it about this pharma subject....
Thanks alot...
You are an amazing TEACHER!❤️
What a great lecture! Thank you so much!
Excelent video!As a medical student , this video helps me a lot to understand better some important basic concepts.
thanks....u r a great teacher..wish u were in my college
You are the best! I really respect.
Thanks you professor, arbsorbtion of weak organic acids and weak organic bases drugs is pretty understood.😊
Hi prof, you ‘re great genius ,thank you so so so much for your amazing explanation , The way you put information is to take root in the brain, I ‘m watching your video during my third stage of pharmacy university and I send your video for my friends we are thank you so much
With lots of respect,love and estimation {from Iraq 🇮🇶}
Thank you so much! this is SO helpful!! :)
Amazing video. What a great professor
Thank you so much professor Fink
Your way to illustration is very interesting
sir i am ur big fan...u made pharma easy for us...we pay u nothing bt we can pray for u....Allah almighty give u faith and success..
great job sir.... awesome lecture
Tons n tons of best wishes and huge huge respect frm kashmir.....
Sir you are brilliant n genius
Ideal teaching style
Your precious lectures really helped..
Really helped me alot
Thank you so very much!
Amazing lecture!
Great Teacher!!
Love these lectures
awesome lecture!!!!
Thank you for such amazing lectures Professor Fink, keep them coming, I'm using these for my Pharmacology exam next week at my nursing school, that can be waived if I'm able to pass it via competency exam, I'm able to process the material much easier through your lectures, btw, please put up any lectures on nutrition if you've any, thanks in advance!
Wow thank you for your videos. That was really helpful and kept me interested. I was having such a hard time but now its so much more understandable.
thank you professor fink awesome video
Thank You prof. you are genius
God bless professor Fink
Thanks so much the extroadinary detail is brilliant and soo helpful
Thank you proffessor.....god bless
It is an amazing lecture.
very usefull thank u ....hope theres many videos in pharmacology !!
Thank you, you are professor of professors.
Nice lec and explanation is very attractive
21:50 .... love that energy 😅😅
Excellent..!!
This man is the best
Thank you so much for sharing this important information. You are an excellent instructor. You will always be part of my journey into the medical field!!
yolanda
This is explained so clearly...why can't you be my lecturer? 😭
its great Thanks Prof.
Awesome 👏🏻
Sir You are commendable 🙏
Thanks professor 🙏
So energetic. NIce
I am a chemical engineer and I am finding this stuff so easy.
Thank you!
Thanks so much!
i enjoyed it!!
Thank you 🙏🏽
just logging in to say thank you!
same, and to have a good weekend, i appreciate you.
Thank u Prof Fink, sharing ur science with US. I just have a question. Around Minute 6 u say that drugs can not enter cells by Transport Proteins. But arent SLCTs Transport drugs into the cell? !
This dude is a genius, in regards to the way he just laid down the knowledge of ph environment determining the form of a drug being either ionized/water soluble state/form vs. non-ionized/lipid soluble state/form! Winning!!! Granted you have to had had some prior chemistry to understand his rationale. #pharmacologymadesimple
Totally! Neither my chemistry nor pharmacology professor could put the relevant concepts together in a way that made sense like this guy does.
thanks man
Amazing; because I got asked via pm, the key thought is the following: Some drugs are administered in a certain form (arrangement of atoms) that lacks H+; if you add H+ then (the drug hits a specific environment - in the video this environment is the acidic environment in the stomach) the added H+ combines with the initially swallowed drug; this reaction adds then a property to the drug: The drug-H+ combination is now lipid soluble; this property of the drug (being lipid soluble) is needed, so that the drug can pass the lipid bilayer that is around each cell; having passed now through the cell membrane and gotten into the cell, the drug keeps diffusing through the other side of the cell and gets into the next cell etc., until the drug went through the whole thickness of cells and reaches the blood stream (e.g. passes the complete thickness of the wall of the stomach); once in the blood stream, it will circulate until it finds it's way to the target tissue (next lecture?).
Question: Can endogen drugs accumulate in fat cells also?
And another question: If weak bases avoid H+ in order to stay in the nonionized, lipophilic state, why would somebody give after a TCA overdose NaHCO3 (stated in another video on YT)? Wouldn't this even increase the effect?
PLS PROFESSOR IF ITS POSSIBLE TELL ME WHICH BOOK YOU USED DURIGN EXPILN UR LECTURE
thank u soo much sir! It's really really helpful and thank u for uploading the video but I think sound should be little louder for better understanding. .. thank u... :-)
Thank you professor for the wonderful explanation. I have a doubt that after the drug enters into the inactive sites is there any side effects or is there any possibility of induced effect for the inactive sites.
As I describe in the Video Lecture, when the drug is at the inactive (acceptor) sites, it may not have any action on the body at the present time, but the drug IS still in the found and potentially active if it "re-distributes" (as I explain on the Video Lecture).
thanks Doc>
I love Ur Style in lecturing but i wish if i could have a copy of your lectures.
thanks again
peace from Iraq to U
you are awsome
professor Fink, I work with general surgery pt. who are on pantaloc or Zantac etc, they can have feeding tubes, or decompression tubes, and sometimes nothing by mouth diet. while they need their baby Asprin(81mg) because of their underlying conditions. if their stomach acidity is reduced to such degree and taking low dose of Asprin is already too low of a dose, not to mention when you use the the crushable form of the Asprin to agree with the feeding tube. I feel like it only gives them side effects( to irritate the GI lining). Is it even worth giving them. Their is hardly any bioviability. We give standard enoxaparin for prophylaxis while in hospital.
if a drug is lipophilic(hydrophobic) then how it will manage to cross the hydrophilic heads of membrane which are the first boundary?
Good Question! The hydrophillic heads are so small (PO4 groups) that they do not create a physico-chemical wall or hindrance. In contrast, the fatty acids are some 100X larger (compared to PO4).
This question was inside my mind for many years ...thank you
maybe someone could't tell me if i had missunderstod something. I have always learn that the major absorption site for drug is in the small intestine because of its large surface (villi and microvilli) rather than ventriculus because of the thickness of mocusa in the ventriculus and its electrochemical gradient which is a factors that make stomach a not favorable for drug absorption. But now i have seen this video and Professor Fink is telling that drugs that are weak acid is absorbed through the stomach.
As my textbook says: Thus absorption of an acidic drug such as aspirin ect. is promoted by drugs that that accelerate gastric emptying (e.g. metoclopramide) and retarded by drugs that slow gastric emptying (e.g. prophantheline), despite the fact that the acidic pH of the stomach contents favors absorption of weak acids
i am little bit confuse :/
Thanks for your question.That was very interesting ro research. Here are some satisfying answers I found. pubmedcentralcanada.ca/pmcc/articles/PMC1402550/pdf/brjclinpharm00282-0010.pdf And read here the answers pls. www.physicsforums.com/threads/aspirin-absorption-in-stomach-and-intestine-is-confusing.560217/ Well, it seems so, its much more complicated than what we thought and there are few exceptions.
Thanks Nicat!
Nothing else ,thanks a lot
But... non-ionized substance may still be polar, isn't it? Or are the drugs made the way they always end up being non-polar when they are non-ionized?
Fabulous lecture. I have one Q. In B2 diagram, why the arrow for free drug from gut-liver-bloodstream is bidirectional but for metabolite it is unidirectional. Please respond.
As was explained in the Video, the "active" drug is in the non-polar lipid-soluble form and can easily diffuse across membranes (including returning back to the gut). The "metabolite" is the polar water-soluble form that can not readily diffuse across membranes (& once secreted into the bloodstream will be excreted by the kidneys into the urine).
Y these lectures r incomplete...sir
Take Salam from bangladesh sir
THANKS U VERY MUCH
What the difference between a dose and a dosage in simple terms.? Thanks
A dose refers to a specified amount of medication taken AT ONE TIME.
By contrast, the dosage is the prescribed administration of a specific amount, number, and frequency of doses OVER A SPECIFIC PERIOD OF TIME.
www.verywellhealth.com/drug-dose-definition-and-examples-1123989
Aren't the BBB capillaries composed of endothelial cells not epithelial cells? and encapsulated by pericytes, before astrocyes?
The endothelium is a thin layer of simple squamous epithelial cells of mesodermal origin that line the interior surface of blood vessels and lymphatic vessels. Structurally, the BBB is comprised of specialized brain microvascular endothelial cells (HBMECs), perivascular cells (pericytes) and astrocytes. Also see: kosheeka.com/epithelial-and-endothelial-cells-how-do-they-differ/
pls any body know informtion about which book proffesor used durign explain his lectcture
Check-out professor fink's web-site for additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/
“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp
thnakyou professor finks i got too much informatiion from ur lecture enshla GOD will give u long live with best helathy
🤗
i m from india. where can i find your lecture notes pdf
The Lecture Outlines are available at: wlac.redshelf.com/
Each costs $20. They come as a 100% downloadable PDF which is 100% printable.
goodstuff
Excellent explanation! What else can I say! This only happens in America cause it's hard to find that kind of professor somewhere else. I know what I'm saying cause I studied medicine in an university named Unibe in Costa Rica, and things are quite different over there. The professors they have, most of them, are horrible; they certainly don't know how to explain and the university itself don't give a shit about it. But thanks to professors like Fink, Usmle & TH-cam, I have managed to escape the horrible medical instruction I received there.
is this a med school lecture?
The Pharmacology lectures are presented at the "Allied Health" (Nursing/Dental Hygiene/Resp Therapy) Level.
In fact, I;m gonna make one recommendation to those who are planning to come to Costa Rica to study medicine. Choose a better university that is called Uaca. There the teaching is great, but of course never like in the US, but it's still quite different from others private universities like Unibe which expensive like hell but also horrible as a med school. Take this info from someone who knows this's true.