The Role of Mitochondria in Aging and Disease - David Sinclair
ฝัง
- เผยแพร่เมื่อ 2 มิ.ย. 2024
- Biologist David Sinclair from Harvard Medical School on alphaproteobacteria, reactive oxygen species, and why the nucleus and the mitochondrial genome are like a married couple.
Read the text version here: serious-science.org/role-of-m...
Get a bigger picture:
1. Aging and Disease - David Gems: • Aging and Disease - Da...
2. Reversible Aging - David Sinclair: • Reversible Aging - Dav...
3. Molecular Cause of Aging - Vadim Gladyshev: • Molecular Cause of Agi...
Follow us:
LinkedIn: /
Twitter: / scienceserious
FB: / serious.scie. .
Instagram: / serious.sci. .
Support us on Patreon to see more videos: / seriousscience - วิทยาศาสตร์และเทคโนโลยี
Amazing how much younger he looks, 7 years later.
Dr. Sinclair looks younger now (2022) than he did in 2014. That means his approach worked, i.e. diet, intermittent fasting, supplements, etc.
He does. The skin is a good barometer of the health of all organs. His skin gets better every year as I observe him anyway.
...and good genes!
@@robynhope219 botox ?
Before I read your comment I was thinking exactly the same thing. Hair, skin, eyes, colour - all look younger today, 12 years later. 😳
That’s for sure. His lab discovered some heavy stuff and didn’t published it yet. 100%
I just turned 70 and I feel great.
After this watch a recent video of him. Six years later he is visibly younger.
Because he can no longer move his forehead?
your analogy of the broken marriage of genomes was the best part....
You are very competent and humble, Dr. Sinclair. Pls explain how we get NAD...
I like the joy he has
OMG.. He is just genious.. Everyone please support Dr. David Sinclair.. He is doing a fantastic job.. God bless you..
The world is watching you Dr. David Sinclair.. You are our hope..
Indeed...and his obsession with anti aging is to all our benefit :-))
japan england & brazil r also almost figuring it out
I don't want to live forever. I just want to be healthy and live an optimum life while I'm in this body.
check Jerry Tennant
That’s his point exactly!! Have a healthy life.
@@seths6069 thank you. You as well
Stop using canola oil and margerine and use olive oil and lard for cooking
Don't you want to live to be 231 years old!
sleep, nutrition, movement, absence of stress, good emotions +++
Easier said than done I think?
yes....
Sleep right
Eat right
Exercise right
Think right
so glad I found this . .
Been on NAD, 100 mg. /day for almost 2 1/2 years
along with Co-Q10, Carnitine and Creatine as also being mitochondrial supporters
and at 72 function and perform as a man many years younger
but it's also about sleep , stress, recovery protocols for the gym work-outs and so forth.
@Joseph Williams based on cost and availability and convenience-Amazon and a typo, it was NR, not NAD, which i quit about 9 months ago
just not enough good data to support a 300 mg / day dosing- influenced by Dr. Rhonda over at found my fitness . .
@@Farhan-hs1bq shortly after "that' Dr. Rhonda Patrick. foundmy fitness iirc
posted that uncompelling and speculative evidence wrt either NR or NMN didn't support enough actual chemical / medical detectable mitochondrial boosting beyond wishful thinking / antidotal evidence ,
tho the chemistry looks like it should,
not all us of have the benefit of unlimited or even "free" sources for NR or NMN in the gram plus doses that "might' do something
besides being exorbitantly expensive
ROI- evidence lacking
eat smarter. workout and recover smarter. reduce stress, learn to sleep better
and don't watch too much of the "news"
NAD is so expensive that only the well-to-do can afford it:-(( I take Niacinamide, which is cheap... helps boost NAD. Did you know?
@@robynhope219 keep researching seems minimally effective
Life Extension products !!! Now IVs of NAD
The best 🎉
Incredible - now I just need to find a reason to live - lol
Keep doing the lottery and hope for the best !
or move up hill into a cave and meditate avoiding contact with other so called human beings - ironically this is why he doesn't want to live - a culture based on money @@kevinfairweather3661
I know the feeling. Why the *FUCK* would I want a longer life as the headcase I am now? XD
Why Not Now Hope you found your purpose!
Because nothing is more satisfying than outliving your enemies ;)
I volunteer for that aging research!!
Amazing work Dr. Sinclair! So impressed with not only your work but your ability to explain it!!
Sir I have read Your book "Lifespan" on the same topic of aging - It was too informative ..I am Your big fan 😇..Loads of love from India.
Every human should have this book.
I love when he smiles as is a good thing happening! 😊
The price for The NAD Treatment Center Detox Method can range between $6,000 to $17,000, depending on the specific program that is recommended for you and discussed with NAD Treatment Center staff. For reference, a typical 10-day treatment is $11,850.
As they refer to hypothesis as theories, leave out causes of disease then jump to administering pharmaceuticals, you know they are only keen to make money instead of helping human life.
Infrared Sauna & Oxygen Therapy might be better & cheaper alternatives
Excellent lesson and info. Thx
So exciting! One can try a lot of this right now, and very safely. My goal is to live heathfully for however long I do live, and this research is exactly the ticket.
Wow loved this video!! Thank you David!
Thank you for the information.
Very succinct explanation !
Lo increíble es que su teoría sobre las mitocondrias fue reemplazada por un nuevo descubrimiento, el de la epigenética y ahí empezó el boom de los experimentos.
Thanks it is fascinating!
I understood everything!
Great talk theorizing the future of mitochondrial development as related to aging and longevity,
Very informative information 👍🙏
Amazing wow its good for me to enjoy my life with my family.
The body likes to have a 700:1 ratio of NAD to NADH according to a video by Shallenberger. That shows how important NAD is.
Every medical professionals should learn this.
Thanks Dr. Sinclair .. a fan ... will be watching the outcome of your research ... since I am specializing in mitochondrial dysfunction pertaining to aging from a dietary approach, since as you know we have longevity mechanisms that repair all damage ... we just have to get out of there way and support our own metabolic processes as these bodily mechanisms are far more powerful than any supplement you can take ...,
70 Going On 100 … the Centenarian Diet … maybe 70 Going On 128 … the Hayflick Limit, or if a fan of Ray Kurzweil … then this is all a Moot Point.
Specializing in mito dysfunction?
How do u help ur patients? I had a question: how do I get rid of zombie cells in the feet?
@@robynhope219 he died. That's why he didn't answer your question.
No so Serious Science! Love it 😀
excellent.thanks
So where do you find this magical "NAD" in nature? Please say donuts
hahaha
Milk has some in it but best to supplement with NR (nicotinamide riboside)or NMN
@@davidivers9295 I did a search on "restore NAD in the body" and was given a result that said the same thing you did:
"Research shows that when taken by mouth, nicotinamide riboside is highly bioavailable, and has been shown to boost NAD+ levels in the body"
@@SrYuba I don't know the answer to that question. Sorry.
If it was donuts you would already have young mitochondria
Thank Dr Sinclair. Can you please talk about fisetin! ? How we can take? I understand that it help the mitochondrial function! 🙏🏼🍀
You can get fisetin from foods..look up.
I'm actually an aging researcher myself. Trust me, the Sinclair lab is top notch. SENS is funding great work, but they're not bringing anything to market in the next 10-20 years is my guess. I don't even think the NAD treatments or protein chaperone treatments Sinclair's lab is studying will get anywhere for years either. Consider that mTOR suppressors can both raise and lower lifespan and we don't fully understand why and we've been using them for decades to get an idea of the technical challenges. My mTOR model is a 26 ODE system. My lab mates said, "Oh that's why no one's made a good mTOR dynamics model."
Benjamin Hardisty o
Benjamin, there is a product that offers the solution you seek, reducing oxidative stress by an average of 40% in 30 days proven in a clinical study. 22 more studies follow this. Based on ancient herbal and plant wisdom. Have you heard of nutrigenomics and the Nrf2 pathway? We are biohacking our genes now.
Benjamin Hardisty. Have you looked at the peer & scientific studies on Protandum?
Never trust anyone who says, Trust Me.
The one thing that really bothers me about this discussion is that it ignores the elephant in the room. People in the U.S. have a shorter lifespan due to pharmaceuticals that cause mitochondrial dysfunction. Flouroquinolones is a biggie, but almost all CNS drugs disrupt normal sleep and actually cause premature aging of the brain.
Thanks it is fascinating
Very insightful, Doctor Sinclair. I can clearly see the worth of you living a longer life because you are an important part of human society with your intelligence and knowledge.
You are our mitochondria. But , what do I do with a longer life or that of billions of people. ? .....?....Like , I do not want mice to live longer lives.....
Its true Mitochondria are powerhouses of cell The no. Mitochondria shows cell activity they have theit own DNA can live independently .more no. Of mitochomdria shows cell activity. They pla y imp role in cell division. produce ATP which release kinetic energy in the form of phosphate bonds.More in muscle cells named as sarcosomes.
He definitely looks younger now, wow
what's calcitrol? i saw it in the the Closed Captioning. Mitochondrial Autophagy is caused by Parkin-pink1. Parkin-Pink1 attaches to a receptor on the outter mitochondria membrane. there's 2 types of autophagy. Selective Autophagy from pomegranate's elligic acid and a specific probiotic trigger selective autophagy and universal autophagy from Intermintent fasting. Autophagy is when a damaged mitochondria gets enveloped by a membrane with a libosome. And breaks the mitochondrion into amino acids. to be recycled back into the cell. selective autophagy is the type triggered by high ROS from damaged mitochondria.universal autphagy just autphagies them all, except the Mitochondria. beacause the mutant mitochondria don't.produce ATP. So no ROS by product. to help facilitate the bond of Parkin-Pink1 to the autophagy receptor on the outter membrane.
i know South Korea has developed a healthy mitochondria injection method.
and England has their mitochondrial donor program for three parent babies.
Is there a connection between mitochondrial fuction and telomere? i wonder.
Great lecture, sounds like the progression of insulin resistance. Thank you
fantastic comment
Thank you very much.
Cool video and understandable.
INCREDIBLE
I love this so much
I am nearly 65 and have found that taking a small amount of D-Ribose and some Creatine daily has given me a massive amount of energy and strength so much so that two or three days a week, I will run a 5K followed by an hour in the gym doing a heavy workout and then do about 3/4 hour of swimming and still feel like I could do more. I suspect am as fit as I was in my twenties.
Don't forget to take Potassium.
You need A LOT MORE of it because of the muscle work.
Look into it
Potassium Sodium Pump
😉
What is D ribose
The human microbiome directs the communication between the cells and mitochondria as well as between other cells. One example is the role of menaquinone or vitamin K2, synthesized from vitamin K1 or phytonadione by certain bacteria in our gut, as a participant of the oxidative phosphorylation or electron transport chain (where 94% of cellular energy is produced) through its ability to accept and transfer electrons.
That would make a lot of sense. Do you have more info besides the vit k?
I believe your idea but never found a way to prove it can we chat I would enjoy talking about mitochondria and it’s motility and other cool things
Thanks for this.
Reduce inflammation!
Hm, his current 2019 theory describes aging in terms of epigenetic decline which seems quite different compared to mitochondria-nucleus interaction. Although in both cases decline in NAD plays role. Just questioning how reliable is all these.
Typically in science we see results based on a false understanding of what is happening and with prolonged study realize what is actually happening. In other words, most scientific findings are essentially by mistake.
Excellent. A very well spoken Professor. I have so many questions! Would taking NADH
assist in this regeneration??
No. Use NR. (nicotinamide riboside)
Lelouch: Suzaku live.
Suzak: Should i take NMN, Metformin and resveratrol like Sinclair.
Code Geass
It's a hypothesis, not a theory, yet. This reminds me of Dr. Dean Ornish's idea, back in the mid 80s, of reversing heart disease with diet only, quickly. Many in the medical field scoffed at him and chastised him for his foolishness. Now we know the truth. He was right. Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in. Could be a game changer for sure.
saxmanchiro Ornish right? You apparently have not read any studies in the last 20 years.
Green Deane Did you read my post carefully? I said in the 80s.
If I told you I'm part of the company who currently has a Patton on the product and if you are interested in not just hearing how well of a theory it is. But to have a real testimony from a product that is not being rested but distribution. Contact me at DKHANDYTEST1@GMAIL.COM
+saxmanchiro "Sometimes, a crazy idea in science gets ridiculed until the irrefutable evidence comes in."
Such as this theory confirmed by this evidence?: www.researchgate.net/publication/273789709_Risingfalling_mercury_pollution_causing_the_risingfalling_IQ_of_the_LynnFlynn_effect_as_predicted_by_the_antiinnatia_theory_of_autism_and_IQ
robinclar I wasn't aware that mercury linked to Autism could be considered at a 'theory;' level yet. I have an autistic child and keep myself updated. Plus, my other son is a published scientist within healthcare and has worked with Dr. Piven from Chapel-Hill who is a world renowned researcher in Autism. I will read this over and see if I can get my hands on the full transcript instead of just the abstract. But thanks for sharing this with me.
His own appearance has also changed quite drastically if you look at him today, i swear, his five years younger today, five years later, so his own concoctions seems to work..
Congratulations Its help a lot.to have hope in many people wants to have long happy life.
Such a lovely man 💫
thanks for caring and sharing
Got to hand it to him. He does look younger now than he did back then.
This is almost 6 years ago and he looks younger now...
Ikr?
That's the point!
I was just about to make the same point. Sinclair looks significantly younger now in 2020 than he did here in 2014. I'll stick with the NMN and other longevity aspects of my daily routine.
He does
I thought this was from today, but when I checked out the date, I thought the same thing. It's undeniable. Started NMN and Resveratrol today!
You still have to stop cells going into senescence after repeated cellular replication. One way of doing this is to maintain telomere length.
Protandim does just that!
The mitochondria also play a major role in epigenetics and maintenance of the nuclear DNA, hence the their importance... The microbiome also may control about 30 percent of gene expression
PROCESSOR302 Or Exercise and calorie restriction to modulate AMPK and mTOR to extend telomeres. Or use senolytics to kill senescent cells, and prevent cytokine from inflaming nearby cells.
@@ACTHdan bit late to this discussion but could someone break it down what is best to follow in layman’s terms if you don’t mind, it would be greatly apprecated
@@ACTHdan bit late to this discussion but could someone break it down what is best to follow in layman’s terms if you don’t mind, it would be greatly appreciated
I thought this video was made in 2021, because he looks exactly the same today. Something's working.
I am 59 years old. My husband is 64. I feel like I am getting younger. I have lots of energy and are able to do 12 hours hard labor. My husband looks like a really really old man. I often wondered if I am too young for him or if he is too old for me. My whole life I had the idea that I am slow. It is strange and I could never really understand why I am years behind other people. I do catch up eventually but then they are old and I feel young. Today something just popped up in my brain: Micro Con dial. I had no idea what it is, so I googled and find this video by David Sinclair. Does this make any sens?
Hi Nicoleen, how has your views changed since you posted this a year ago?
One of the sexiest scientists out there.
What’s the best NAD supplement on the market? I’ve done NAD IV treatments before (you feel TERRIBLE while doing them) but that goes away pretty quick when it’s finished. My primary concern is anxiety, brain fog and fatigue.
I have tried Niagen about a week ago , Im still sceptical but, I have(had
) 3 loose teeth , but just yesterday I noticed 2 of those teeth have tightened by a large degree , the 3rd tooth is still loose but even that tooth has tightened ..so after week I have hopes that this product is working,(re edit (3/2015) after 2 months of Niagen...I am completely amazed at how well this works, I could list 7 or 8 improvements all over my body ...the most recent amazing thing is..I have been diagnosed diabetic for 5 years, I still eat the same ,.. but I have had to reduce my med intake (I probably will quit Glyburide soon) because my glucose levels were dropping to normal by themselves , I lost 8 lbs of fluid retention after the 2nd week... I am 165 lbs from 173, never realized the bloating in my face & body until I looked at a video from Nov 2014 & compared it to a video I made a couple of weeks ago..1 thing I can say...thanks Dr, Sinclair
Hey man, how are you doing since you first started taking Niagen?
I love anecdotes
GrooveDoctor77 is niagen still working for you?
Where did you buy niagen also how old are yoi
Sinclair looks younger now that he is 50
Indeed.
Did he say we are not living much longer than we did 10,000 years ago? How does he come to that conclusion and on based of what data?
But why do the nuclear and mitochondrial genomes stop communicating in the first place? What causes the nucleus to think that it isn't receiving enough energy?
icecaloric Something genetic.
what about the supplement Ubiquinol( Co enzyme Q10) this is supposed to raise atp production?
Grace 2U with PQQ.
Amazing
Wouldn't it be possible to look at the mitochondrial bacteria types which are living outside of human bodies, where they are less protected, to find some gens which could be used to make our Mitochondria more resilient to damage and mutations?
I concur as I think that once the Mitochondria has been damaged are they able to repaired?
@Alex Brilliant idea. Truly.
Ketosis increases NAD+ to fight off inflammation
And Fasting helps.
And also help with Diabetis 2 diet related
David Sinclair looked older when he was younger & now he's older 7 years later he's looking younger.
NAD levels can be raised naturally through caloric restriction and/or periods of intense exercise. Either of these separately or in combination create periods of negative energy balance within the body which raises NAD levels. There are some supplement companies out there such as Life Extension who market nicotine riboside as an NAD enhancer. I wonder how safe this would be for someone to take who is already engaging intermittent fasting/caloric restriction and/or a fairly demanding daily exercise regimen?
IF...repairs our cells...right?
NAD is just a coenzyme that helps with the production of ATP. Apparently it's also used for mitochondria to communicate with the DNA in the nucleus. I'm pretty sure high levels of NAD triggers the cell to produce a protein or chemical that makes metabolism more efficient for the cell.
The best product for mitochondria is ASEA. Cell sygnaling suplement contains active redox molecules -- cellular messengrrs that efect genetic expression in a positive way, helping to protect, rejuvenate, and kiping cell functioning at optimals level.
I think efficacy is more of a question than safety. Many life extending interventions work only in unhealthy animals. Add to that the fact humans already live proportionally long (for their size). You'll see much better results in mice than certain bats for instance, whose physiology already appears near-optimized for longevity.
@@vincentnapolitano952 Yes. IF gives the body the appropriate time to deeply absorb nutrients and deplete all stored sugar in the body.. then repair mode follows... all damaged cells, harmful bacteria and worn out tissue becomes food.
Looks like David Sinclair's methods are working. In his latest videos he looks younger than he was 9 years back.
We live forever in heaven
Excellent Research
Belfast Ireland 🇮🇪 😎
is it bioavailable orally? does it only restore muscles to a youthful state or all cells and that is just the example he used towards the end of the video?
Yes, NR is orally bioavailable. I used it for a while, but it induced insomnia for me. I could take a low dose, but I suspect it was too low to make much difference. People report a variety of effects, so it probably works in more than just muscle. Your results will depend on the present condition of your mitochondria. If you're young, you may not notice much.
How do we know the nucleus makes the proteins?
"I do not want to live forever in the memory of the people.
I want to live forever in my apartment."
Woody Allan
Interviewer: Mr Allan, do you want to be made immortal through your work?
Woody Allan : No, I want to be made immortal through not dieing.
@@gleaveinjapan screw Allan.
Does NAD help people with MS?
So if i have less functionality of mitochondrial DNA or i dont make enough of it when young i would die of a lack of cells with enough energy to run a marathon, when i am older, i am so glad it will happen later than earlier in life, but when is the cut off point when mitochondrial DNA start to grow less useful
Well yeah !
2014 pretty old news has anyone an update? It is possible now to get all the supplements to keep the krebs cycle humming and the ETC working including adjusting the nad+/nadh ratio. I am sure lots f people have tried it. It would be interesting if they would post there results. Although the only test might be still healthy at an advancing age?
Great video, but he failed to mention the most important molecule responsible for mitochondrial function. OXYGEN..... Two words: Ozone Therapy. Learn as much as you can about it. In my opinion it's the single greatest practice we have for restoring health. I actually think the "secret molecule" that he's hinting at toward the end of the video (10:40) is Ozone.
He does mention oxygenated species. That in itself is what you are describing. But seriously, how many millions of couch potatoes are going to head out and start running peak 8s? The answer is probably 1 in 100,000 if that. Also there is NMN found in these foods and just about as many eat this in between the bacon cheeseburgers and french fries. :-) NMN is found in fruits and veggies such as avocados, broccoli, cabbage, edamame, and cucumbers.
PQQ is the secret molecule. It is in the Quinone family - Co-Q10.
Ozone helps me a lot. PQQ however did nothing.
You need to research vit K2 or and L - Citruline for its anti aging effects. It has wiped my wrinkles and made me years younger. I don't know which one is responsible or it could be a combination of the both.
Creatine supplements can increase atp production. Any correlation to this topic?
Indeed, see more information here on my website www.northstardanes.Lifevantage.com
And Co Q10
We all want to live forever. I do not want ever to die I love the universe my home, my father in the havens, love animals. Love my family, love people, love to smell the flowers, hear the birds singing. Love to fall in love.
God bless as all creatures big and small.❤❤❤❤❤🙏🙏🙏🙏🙏🙏🥰
Any of you aware that Metformin decreases mitochondrial respiration? So important to do your research. Dr. S. should mention this.
I love anti aging science
I am Amercan Board certified Endocrinlogist could you give some trading in this new science or rather do you offer fellowship in antiaging?
Hello Fatma, more information on my website www.northstardanes.lifevantage.com
I do think, however, that there is way too much salesmanship in the aging field in general! That def. perturbs me.
There are a lot of scammers, some of them posting right here in these comments.
As true as that may be, how would you propose that new discoveries and new information be made public? And accepted by the folks who need it?
doed the dr take it ?
What determines the actual number of mitochondria per cell? Is it tissue dependent or based dynamically on energy needs?
Bruce Hay on the HumanOS podcast, mentions with respect to mitochondrial genomes, you have hundreds to thousands of them:
"In every cell we have hundreds to thousands of these organelles floating in the cytoplasm. They’re always being generated, and they have their own genomes. It’s not just one genome for all mitochondria, but thousands."
Does he mean that each mitochondria only has a portion of the mtDna? Isn't the mtdna so small (37 genes) that it barely codes for proteins anyways (13)?
He goes on to say, that the "nuclear DNA is well positioned for repair, because we have two copies of all of our chromosomes. What that means is, that if the copy you inherited from your father is damaged in some way, the copy you have from your mother can actually act as a template for repair. In that way, through homology based repair, you can oftentimes reconstruct the information that was lost in the damaged strand."
There was a good 'Ask Me Anything - with Spencer Wells and Razib Khan', but didn't cover basic questions like this.
Interesting topic Doctor but it's very theoretical and still no technique or medicine or diet strictly to improve mitochondria function is available.
One thing which I never understood about is free radical?
According to biochemistry free radical is the driving force to all the enzymes in body to hasten the function so as to remove the free radical itself so in this process the function of the enzymes is constantly active not in silent mode so what if there were no free radical at all in carbohydrate or protein or fat metabolism ,won't the enzymes go in silent mode and since no activity would lead to death.
Our body needs stress to stimulate and relaxation to calm down so that's why sympathetic n parasympathetic are created ....
So please do make me understand about free radicals Doctor
Thankyou
Shapan L still need to neutralize ROS with antioxidants- such as Co-WQ10.
Did it work out (this video is 8 years old by now)?
Quality and no quantity of life is the goal, to be able to enjoy what remains of life without getting sick
My neighbor's Mom is 80 years old, and she milks cows, was riding a horse daily in Mexico, she doesn't ride the horse anymore. She is strong as an Ox.
You don't hear the interviewer. Did they simply ask "hey, David, how are you?" and then he spoke for 13 straight minutes? :)
Gordon Seay 😂
Have you ever talked with a scientist before? you ask one question and I swear they won't stop talking. It is nice to hear someone so passionate, though.
NMN cause elevated homocysteine. Please advise
What can we do now...what really work.to slow or reverse it now....nad.plus.