Mitochondria - The Key To Disease and Mental Health with Dr. Martin Picard
ฝัง
- เผยแพร่เมื่อ 13 พ.ค. 2024
- Emerging evidence suggests mitochondrial dysfunction can cause or contribute to many psychiatric and neurologic disorders. To promote metabolic and mental health, it’s crucial to better understand mitochondria and what we can do to keep them healthy.
As Dr. Martin Picard explains, mitochondria are small components of cells that are involved in just about every disease process, and by extension, in every aspect of promoting health. Since mitochondria are where we transform food energy into energy our bodies use, it makes sense why they are so important for health and longevity. Dr. Picard from Columbia University is one of the most prominent mitochondrial researchers, and he joins us to discuss all things mitochondria-related - from the basics of what mitochondria are and how they function, to the three most important things we can do to keep our mitochondria healthy.
Expert featured in this video
Martin Picard, PhD
www.picardlab.org/
Twitter @MitoPsychoBio
0:00 Introduction to Dr. Martin Picard
3:16 What Are Mitochondria and Where Are They?
9:04 Ecosystem of Mitochondria
10:25 Mitochondria and Disease
16:38 Genetics and Mitochondria
19:18 Lifestyle Choices for Poor Mitochondrial Health
22:08 Impact of Psychological States on Mitochondria
25:55 Medications and Mitochondrial Dysfunction
32:12 How to Improve Mitochondrial Function
52:29 Conclusion
Link to Dr. Picard's talk from the inaugural Metabolic Psychiatry Conference in 2022
• Mitochondria in Physic...
The Human Psychobiology Project
www.humanpsychobiology.org/
Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.
Learn more about metabolic psychiatry and find helpful resources at metabolicmind.org/
About us:
Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders.
Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.
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#MentalHealthIsMetabolicHealth
#Mitochondria
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1- move more. 2- eat less. 3- be happy, positive... which requires adequate sleep.
Thanks
What did I learn from this video? That we need more research on mitochondria.
Not necessarily eat less. Don't over-eat. Also, not mentioned here, mitochondria respond and multiple in brown adipose tissue when you submerge in those cold tanks like Joe Rogan has discussed.
Thank you 😂
Ta 😊
Tips from Dr Picard:
1. Move! Exercise encourages your body to produce new mitochondria (up to 2x)
2. Don’t eat too much, it’s ok to be hungry - intermittent fasting is great for your mitochondria
3. A new idea being proposed is possibly your mental state can change your mitochondria (ie., do what you can to lead a life that makes you happy!)
Thanks for your synopsis.😊
If Person have adrenal fatigue, exercice can be dangerous, walk is great, and also fasting can be dangerous with People who have unstable blood sugar..so we should be careful of giving general advice ;)
@@stellaancimer8505 yes hard to no though if we have adrenal fatigue or something else
You saved me an hour! Thank you
@@deepdusto Please, stop criticising and say something helpful yourself.
What to do to improve mitochondrial function start at 32 minutes
Thank you!!
Danke, mein Freund! // Estoy muy agradecido. // Tutto bene qui.
Thank you
Where would we be without nerds! Thank God for their exuberance and passion for their work! Wonderful.
Some of us wear our "nerd" label with great pride. I have noticed that those flinging that term around seem to think that being ignorant is somehow cool (hip). It ain't.
honestly, intellectuals do a lot of damage to the world. those who make actual contributions are in the minority. i've spent a lot of time around intellectuals and they tend to be very degenerate people.
1= move exercise 2= dont eat so much 3= stay positive
Thank you 👍
Bless you
@@jasminejones9937 welcome
@@mrmegabuckssongs was thank you I'll take the blessing.❤
On #2: Eat as long as you are hungry. Stop eating when not hungry. If you think you are overeating, it's probably because you are eating the wrong food.
When I was 10 I learned about mitochondria. I was hooked! The mitochondria is my favorite organelle
It's our favorite too!
PhD biochemist emergency physician here.
Read about alpha lipoic acid and acetyl N carnitine as a combination.
In vitro the combination are the mitochondria's best friend s.
Just need some good studies in people!
Both have some evidence for improving egg quality in women undergoing IVF, which seems to be an very energy dependent process (egg development).
Yah, I take both
I take NMN and alpha lipoic acid
One thing I did not hear in this video was the role of sunshine. I have been hearing a lot about the role of infrared light in melatonin production and melatonin is an antioxidant in the mitochondria.
I go to red light therapy at California Sun spa. 85$ a month. Makes me feel 👍
Finally a person who can discuss mitochondria without finding themselves saying 'mitochondria .... make energy' and appropriately describes them as transforming energy.
But the role in diabetics. Insulin in all this... Is vague in this discussion.. Lots if fluff
@@MrTringuy Do you have a particular interest in (T2) D?
@@MrTringuy A good solid three minutes of information and thirty seconds of sound advice condensed into a mere hour.
@@TheDavidlloydjonesbru 😮 tal...
Picard, "Make it so"...
He's so right that medicine has to move to understanding and fixing problems per the individual rather than "batch" solutions. This is ongoing and gathering steam.
More expensive bills
The problem is medication
Cancer begins when the mitochondria of a cell become so damaged they can't carry out oxidative phosphorylation, but instead of dying the cell manages to switch to the fermentation of glucose in the cytoplasm.
Or switch to glutamine.
methylene blue seems vital, fyi
And the body cannot control the growth. Some use ketones as well
@@dana102083 which ones?
Are you talking about anaerobic growth?
The powerhouse of the ... brain, immune system, emotional health, neurological health, cardiovascular health
For some reason you forgot the genitals... Just sayin
Reproductive@@Jack_Schularick
I think there are 2 main things that hurt mitochondtia:
-burning glucose most or all of the time. This happens whenever you consume glucose, you know, carbs. Your body has to process consumed carbs before it can use fat.
-Eating and processing food constantly. Eat 1 or 2 low carb meals. Not 6 meals.
Be a fat burner producing ketones. Practice time restricted eating and extended fasting to induce autophagy to repair and rebuild mitochondria.
0:04: 🧬 Dr. Martin Picard discusses the importance of mitochondria in metabolic and mental health.
4:07: 🧠 Mitochondria are like the brain of the cell, involved in transforming energy and processing information.
9:35: 💡 Mitochondria transform energy from food and oxygen into different forms of energy, such as ATP, which powers human function and consciousness.
14:39: 💡 Metabolic dysfunction, including insulin resistance, can impact mitochondria and energy flow in the body.
19:53: 🔬 The video discusses acquired mitochondrial disorders and how they can be influenced by psychological states, chronic stress, early life adversity, diet, and exposure to insecticides and pesticides.
25:12: 💡 Communication between the brain and body is energetically demanding, and mitochondrial biology plays a crucial role in this energetic connection.
30:20: 🧠 Psychiatry should focus on short-term acute episodes of psychosis and explore alternative methods to target mitochondrial health for long-term treatment.
35:50: 🏃♂ Physical activity stimulates the production of more mitochondria, which can improve energy levels and overall health.
40:35: 🔑 Individualized medicine, moderation in eating, and positive psychological states can promote mitochondrial health.
45:15: 🧠 Feeling positive and having positive experiences can improve mitochondrial biology in immune cells and potentially in brain cells.
50:39: 🧠 The speaker believes that the current framework for understanding mental health is overhyped and disempowering, and suggests an alternative framework that respects individual differences.
Recap by Tammy AI
💫
'Mmmm--Aaazzzziiiinngg
I have been meditating for many, many decades, and have used visualization as well as breathing techniques in conjunction with adequate exercise, nutrition and healthy sleeping habits. I discovered visualization of healthy, long mitochondria is very essential to staying healthy and fit (I am 52). Concentrating on the digestive system, and the brain are essential if you want to increase your physical and mental health as well as draw positivity into your life. The key to spiritual, mental and physical well-being is recognizing and visualizing the same science that we obtain in the form of products and healthy regimens, and it shouldn't be left out. Visualization is the the missing puzzle piece to our completeness.
I agree with you. Our visualization nourishes our body.
I-theist?
Would you elaborate what do you mean by visualizing things?
@@akoaykilalamo Well, to visualize you need to look first at a structural form in your mind. For instance, breathing techniques start with thinking of your lungs as a paper bag, which you fill from the bottom up, then empty from the top down.
If you can find a good book on chakra cleansing, for instance, visualization of the chakras are at the heart of the procedure, as you imagine each chakra as an orb of a certain color, rotating in a certain direction. You can apply the same technique to any scientific information that you can give structural form in your mind to, in any way that suits your intuition. Open your mind to interpretation and the true meaning and definition of life will in turn open to you.
One of the best comments I’ve read in years.
God bless you sir.
Methylene blue.. started for mother with alzheimers...lots of improvements...it's helped with mitochondria health, regulated neurotransmitters so is excellent...discontinued psychotic drugs..her speech started coming back..excellent awareness...accepting lots of new healthy foods...also discontinued sleeping pill..sleeps 8 to 9 hours on her own
Also try 1/2 tsp mct oil ,,u help feed brain I went up to tap,,it helps glass brown bottle so it's not rancid use good company it's worth extra cost as u don't use loads
That's terrific to see improvements. Check out Dr. Dale Bredesen interviews on preventing & reversing & slowing Alzheimer's & other dementias. He was a resear h neurologist for 20+ yrs, looking for the silver bullet that would reverse/slow/prevent Alzheimer's but they kept coming up empty as had every other researcher/pharma. Finally it dawned on him that dementia is caused by multiple factors interplayed, like angina/heart attacks - so needs multiple simultaneous lifestyle, vitamin, medication changes. Get more improvements the more changes you make (some easy and free like decent sleep, drop processed foods for more whole foods and minimally processed or homemade foods, time your meals differently with a 9+3 fast overnight, regular exercise, stress relief and some, if needed for a particular person, more complicated and expensive, eg removing mold from house or moving out of mold-inhabited house.)
He's wriitten 3 or 4 books by now - highly recommend but would start with an interview or two of him available on you tube.
@@lynlawley8903 thank you but no need MB and all the array of supplements and brain peptides have done the great change
I’ll second MB.
Have my friend with a TBI on it and he is gaining so much more mental clarity and focus. I take it as well and love how I feel on it.
The Blue. Which removes the blues.. Wow
This is an absolutely wonderful explanation of mitochondria. Thank you. Please give us more!
Thank you! We are happy you enjoyed it.
Interesting! My energy levels are often not too good, since my diet is not ideal and I do not take enough physical exercise. However, I have seen in my life many, many times that when I am suddenly able to fulfill my calling, I immediately feel energized and I forget about the tiredness.
I am completely together with you on that one
Do you have a daily weekly exercise routine? I walk 10-15mins before sleep.
Maybe more protein? They say we need 100 grams a day
If eating ketogenic it's possible you're lacking salt. Sodium, potassium and magnesium. Even after years keto I supplement ALL 3! I put redmonds real.salt and no salt for.potassium in every beverage i take (more in water), and take magnesium supplement at bed.
I take 5-7g od sodium, 5-7g potassium and 200mg magnesium biglycinate. I'm telling you as people supplement but often don't realize how little they take. I'd start with 3 to4g minimum and work up from there. Take magnesium baths or foot soaks too.
Many people also don't eat enough protein. The absolute minimum is 1.2g/kg body weight and aim up to 2.0g/kg if obese or over age of 50. This should be fatty meat on the bone with skin. Eat organs if you can intermittently. Eat varied sources and add seafood and fish. Leaner items like fish may require adding more fat to the meal. If losing weight vs maintaining requires a heavier fat approach to maintain and can be a lot. If you eat the fat coming on meat it makes it easier. Fry your meals in tallow, lard and butter. Eat eggs. Avoid all keto products and heavy use of nuts, dairy and sweeteners. Keep it super clean but pound the salts. I went from 8 weeks of keto flu to changing my brain fog and energy levels as I figured out the salt levels I required.😊
@@dana102083Dana, how do you decide how much sodium, potassium, and magnesium to take?
Your ten-year-old learning about mitochondria? At that age we didn't even know about cells. Born in 1952 Sydney Australia :-)
I'd add daily exposure to sunlight. Not burning, not tanning, just natural level on the skin sunlight. We're not designed to live indoors in cocoons.
I am going to follow up on a brief comment made by someone else, because I think it is so important. No mention of the effect of light on mitochondria. That is a great shame because light’s effect on mitochondria is very important. Circadian rhythm. Cytochrome C-Oxidase ANd the very important discovery that infra red light produces melatonin IN the Mitochondria. And melatonin is one of the most important endogenous anti-oxidants provided exactly where most ROS are generated.
Can we have an interview with the experts describing the class of pharma that impairs mito?
Great suggestion!
Tamas Kozicz, Mayo Clinic@@metabolicmind
Yes! That would be amazing!!
Best suggestion I have heard in quite a while! Might be good to partner with Dr. Been (Dr. Been Medical Lectures)!!
I’m an Ironman athlete, and a relatively low carb person. No junk carbs. I listened to podcast #53 of Inside Exercise, where Dr. Paul Coen or (Cohen) discussed his latest research that showed Metformin having a negative relationship with aerobic / mitochondrial promotion in some people.
This dude has fantastic energy.
(No pun intended. )
Very honest information regarding how meds impact mitochondria but we dont know how they actually work and long term effects.
I would love to know how say a 3 day fast every so often affects our mitochondria.
Surely pharma meds longterm is a recipe for disease.
I like his theory on rebound unless we change we will keep getting what we get.
For me its sleeping well. Being active especially outdoors parks and forests and beach walks
Sunshine and swimming or relaxing in water. I like the not eating too much.
Great information look after the mitochondria if you want to stay well.
I eat one meal a day and keep satiated until the next day. I’m a ketovore eater. Has healed my body in many many ways. I wish more ppl cared about what they consume.😊
Without podcast and the knowledge of Mitochondria I would be dead right now. Either by choice or by force. Do not ever give up and never let your doctor be the only one taking responsibility for YOUR health because its YOUR problem in the end.
Recap eat less , fast, move more, feel positive.lead to better healthy mitochondria.Feeling affect your biology.
Same ol same ol. But it's good advice
He forgot to mention, avoid aluminum, and fluoride.
Why ?
fluoride increases the absorption of aluminum by our acidic stomach
And aluminum jams up the midocondrea process…
Dr Chris exley explains how aluminum is root cause of Alzheimer’s, autism , Parkinson’s , MS…
Everybody knows they have to do these things, and yet these two pencil-necks thought people should waste an hour of their time listening to common sense drivel.
Excellent discussion on a topic very much a keen interest of mine for many years, though I am no longer in an academic environment myself. One point not addressed per se, despite some really great questions and answers by you two gentlemen, is that of the potential beneficial role of supplementation supportive of mito health, function, and biogenesis. In particular, PQQ (Pyrroloquinoline Quinone) holds outstanding beneficial potential, not alone of course but in conjunction with good nutrition, regular exercise, and yes, intermittent fasting as touched upon here. NMN (Nicotinamide MonoNucleotide) and/or NR (Nicotinamide Riboside, my preferred form) also seem to function synergistically with PQQ in this regard as well, fostering the NAD+/ATP cycle within mitochondria, again as adjuncts to the above lifestyle components. At just shy of 72, my own health & fitness, physically, physiologically, neurologically, cognitively, mentally/emotionally, interpersonally, etc has never been better, and I consider mito health central to the overall equation. Thanks for a terrific segment guys :)
Very interesting
Thanking you for sharing
Vaccines cause mitochondrial disease/ dysfunction. Not always born with it, it’s induced.
Dr. Sarah Myhill and 2 other doctors came up with a blood test that measures ATP. I believe it is within the first five chapters of her book: The Treatment of Chronic Fatigue Syndrome and Myalgic Encephalomyolitis. It's an excellent book. I have had MECFS since March of 2017. Her book has helped me to improve to about 70 to 80 percent.
Thank you for this discussion. It is very necessary for us who have MECFS.
Also, Ron Davis from Stanford University has come up with
another blood test for MECFS back in 2019.
Thanks and God Bless for what you are doing!!!!
Miss Monique 🙂🙏🌷
Would you mind saying what has helped you most?
Supplements? Meds? Other stuff?
Ps great to hear that you have recovered well.
@@alicequayle4625 What has helped me the most is understanding the condition of MECFS and the methylation system.
Supplements that help the methylation system are: B12 plus Co-Q-10, D3 at the same time every morning. Also, I wash that down with a drink known as Emergen-C.
After breakfast I then take another supplement which is a combination of Acetyl- L- Carnitine and Alpha Lipoic Acid. All these supplements can be bought at Walmart. Since I can't swallow pills , the first three mentioned are gummies. I was taking D-Ribose for a time. That helps a lot, but it is very expensive at my vitamin store .
Another book by Dr. Teitelbaum is entitled From Fatigued to Fantastic. The acronym for his system is SHINE: s stands for sleep , h stands for hormones, I stands for....I don't remember, n stands for nutrition and e stands for exercise as able.
Both these books in combination should be the textbooks for all the doctor and the patients who have MECFS.
Another book that I find helpful is my Bible. I get great encouragement from the Scriptures. God is our Creator and God is our Healer.
Hope this helps. Spend the money on both books it's worth it.
There is no ,"cure" for MECFS....we all need to work on ourselves and do what is best for ourselves.
God Bless you and your family 💖🙏🌷💗🙂🙏 Miss Monique
Thank you for posting the name of these Doctors & especially the book. I was diagnosed with MECFS in 1992. (Back then, it was called Fibromyalgia)
@@lizrichard3137 Dr. Teitelbaum differentiates between MECFS and Fibromyalgia, and so does Dr. Myhill.
God's Blessings to you 🙏💗🙏💗
Miss Monique
@moniquelemaire5333 Wow, thanks for info! I'm way behind on the research, with no time or energy to read, but I'll look the names up to see if they have videos, I can listen while doing chores. May God bless you as well! 🩷🙏🙂
High rep weightlifting can increase mitochondria, especially using leg muscles.
Yes and ketogenic diet
Thanks so much. Can you invite an expert on to talk about exercise intolerance and post exercise malaise, please? I hear all the time exercise is the best way to increase mitochondria, but so many people crash after exercise.
I second this and wish your comment were pinned.
Too much exercise makes me feel grumpy and tired.
Meditation suggests simply observation of breadths and/or sensations all around and over the body. The benefits are profound, slow to appear and lasts on consistent practice.
Considerable time would be involved, so it's important to do it the right way and learn from the right school.
I tried visualization to no benefit. Now practice Vipassana; transformed my life.
Thank you! My health took a dive after a high dose statin therapy. From what information I could glean, and there is not much, my mitochondria were negatively impacted system wide. Nine months later, I am beginning to feel some recovery.
What did you do to make the turn around in health?
Were you able to stop the statin?
What dose of statin was involved?
Hope you, build up all areas do happy things to help n get a glocse monitor to get food that suits you
Ger rid of statins
I just would like to say that. Listening to guys like you makes me motivated and inspires me.
Mainstream is just not deep enough for me.
Hail to the TH-cam platform gods LOL 😁😄✊️
This info is so important! Thank you!!
Great information. Enlightening experience listening to this podcast. Thanks so much for this crucial knowledge 🙏🙏🙏
So well explained, such a thoughtful posting. Learned so much. Thanks
Glad it was helpful!
Fascinating! Thankyou for this important discussion 👏
It’s amazing to think how we feel affects our mitochondria…
Therefore the ACE study and stress really highlights how impactful negative events and negative thinking has on people and populations…
I’m wondering out aloud how the recent pandemic would have created long term impacts utilising this research…
This is such a great podcast, thank you for taking the time to create this.
Yes, health is very dynamic and with personal growth and taking more responsibility for what we consume from thoughts, relationship dynamics to emotions and life experiences we can create amazing health.
❤😊so knowledgeable health podcast truly educational ❤😊
Really really interesting. I work as a diabetic eye screener, and I'm getting more and more interested in human biology. Both for my own benefit and the patients.
Now that's what's an informative interview. Great.
beautiful expalined! thanks both
excellent discussion, thanks! A Picard never disappoints! #StarTrek
TH-cam algorithm kept showing ad about StarTrek games while I was watching this video 😂
Wrong, this video clearly is lacking. He fails to mention the benefits of red light and near infrared light therapy (650 and 850nm) on mitochondrial rejuvenation.
Nor does he mention methylene blue supplementation which is a salt that when consumed as an OTC pharmacy supplement, improves mitochondrial function, also.
This is a fascinating film, thank you both very much!
Love the passion ! Great Information. Thanks.
What an amazing channel.
What a superb interview and acquirement of excellent knowledge at first hand! Thanks to both of you and especially to this unpretentious scientist named Dr Picard.
So informative! Life changing knowledge, literally!
Thank you! 🙏🤍🙏
Thank you so much for your content ❤
This so great,thank you!
Well, that’s good news! I wake up feeling guilty and stressed that I have paid for exercises classes that I didn’t attend but very happy and content snuggling in my nice warm bed. I’m active though, I love my job and pottering around the house doing stuff. I also do intermittent fasting because it’s fun for me. I must be one of those low responders…
Same WhatsApp group with you
So grateful for beautiful an important seminar!!!
Really interesting when talking about positive thought and mitochondrial health. I have stage 2 Emphysema and though I lack lung capacity, perhaps 60%, the combination of staying healthy and my state of mind helps my well-being. 1. I move every day, most days extend my capacity. 2. Eat healthy and miss meals. 3. Stay positive and active with creative pursuits. I'm 65, 75Kilo and fit
Great information! Thank you. Trying to improve ecosystem of my mitochondria by practicing fasting, exercise, and diet OMAD making my microbiom happy. I feel big improvement in functioning/strength of my body over last couple of years. Info in this podcast is golden. THANK YOU! Happy New Year 2024!
Happy New Year! Glad you enjoyed this podcast.
🎉❤🥗🛌😄🧘⛷️🎼💧🙌 a little of everything and not too much of anything ❤️
Thank you so much for such n inspiring discussion!
Thank you, helpful interview!
Function of mitochondria and need for customised medication or preventive care; well explained. How mental exhaustion kill more than physical understood well Drs. Thanks a lot. 👍 Alredy talks are going on that there will be customised medicine formula; which as of now is limited to movies.
Excellent interview 👏
From memory the brain is 2% of Body weight, but uses 20% of the entire bodies Oxygen needs, ten times more than any other organ or tissue. At 62 I use a number of supplements and "Zone 2" exercise (I think) a combination of intense interval training along with Heavy weights 2-3 times per week, 1-2 long bike rides, 1-boxing session for coordination, 2-outdoor circuit sessions, with a group of middle aged men. After a major head injury 5.5 yrs ago, improving brain function-hopefully repairing the brain became a focus of mine. I've had significant improvement 95-99% better with improvement in energy...
Try photobiomodulation using 850nm near infrared light for cognitive benefits.
Do keto to improve energy for your brain
At 36.40 a very good simple explanation of the bad effects of food/energy overload beside just storing fat.
Thanks! Time stamps would b v good for this long video
Keep up the good work.
A fascinating and enlightening discussion; a fusion of biology, psychology, physiology,nureology..
@deepdusto do you believe your body exists?
A very interesting and informative interview - we can shortcut that to a 3i vid ;-) I 'see and hear' layers of potential support or damage - environmental as in toxins in the world we live in, food/diet, psychological stresses. It would be interesting to see differences in the health of the mito in Tibetan monks vs 'Bob Smith living in central Manhattan and working in the Investment Banking industry' and also appreciating whether divesting bad layers allows the mito to heal / get back into optimal function.
Anything that affects coenzyme Q10 shall affect mitochondrial function, including statines for instance.
N they know this so why is health service still pushing it WHY
@@lynlawley8903 depopulation run by government s
@@lynlawley8903 because too many people have terrible diets that lead to heart attacks from clogged arteries and aren't willing or able to change diet and lifestyle. So the option left is statins. It's unfortunate when there are other ways but v hard to.force ppl to change.
I need this lecture very much
So grateful for the research presented here! As others do, I too research to improve health w/o extending dependence on phamaceuticals. Any new researchers with potentially actionable steps like those shown here are treasures to those who have psychotic symptoms. While a researcher and not a physician, the knowledge that research has gained is hope for diseases cruel and often hellish. Thank you. Please keep up the good fight!
A fascinating discussion!
This video could be Life giving ❤
I’ll tell a personal story .. my daughter in law visited from Europe. I had to go to family dr, routine visit to refill thyroid RX.. she decided go with me and waited in lobby with other people.. I ended up staying at dr longer, as usual- new Dr was and our Dr trained her.. when finally I got out my D-in-L was in shock
She saw few so overweight people she never saw in person. They all were pretty young age, but weighted 300-350 -400 lbs , just huge !!! and one such couple had little tiny and very unhealthy looking baby around 3 yrs old
I told her, don’t get in shock, that’s America, baby….
Great podcast.
Very interesting information, thanks for sharing your thoughts.
Amazing information. Welcome to the 21st Century. This sounds like understanding the influence of our medications on our Mitochondria might help us to solve the root causes of our diseases.
Great information 🔥
I had not heard/read that different cell types had differing types of mitochondria. Is this new information, or did I just miss it?
Now I'm curious what those differences are and why they exist.
What’s interesting the discussion on acquired impacts…..and the one you don’t mention is the physiology of oxygen delivery and to me the #1 healthy habit everyone can shift right now (day and night). The impact of voluntary and involuntary breathing influences ALL these things shared. Clinically I see this a lot as it relates to progression of disease and reversal to promoting health. Wanna chat about this in detail many don’t realize (most just talk about rate, and yet there is soooo much more than BPM)
Please ,explain as trying to help my self to what can I watch, and you gave another line to follow but where from help please ,many thank s Llj ,
HRV is connected to breathing… it’s a key point
Info on nitric oxide and ketosis improves it.
Not eating too much - particularly sugar, because mitochondria produce energy by aerobic respiration (another reason exercise helps biogeneis and maintain mitochondria health) but cancer uses sugar fermentation for energy through anaerobic respiration, even when in the presence of oxygen. Sugar is fine when used for energy, preferably complex carbs (sugar), but too much causes many problems beyond the scope here. Allowing a fasting state has many benefits, including triggering autophagy and mitophagy, which recycles damaged and bad mitochondria to make new ones that are healthy, before disease sets in.
There has been some studies on the effect of Near Infra Red light (the part of sunlight that gives you heat - about 700-80nM) helps to correct mitochondria dysfunction through melatonin production in the cell for combating Reactive Oxygen Species in the cell. NIR can penetrate into the body and reach into the cell just by being outside during daytime.
Your views are solicited.
Relevent papers
www.melatonin-research.net/index.php/MR/article/view/19
pubmed.ncbi.nlm.nih.gov/36671781/
Ex EXCELLENT analysis
Not one question or comment (positive or negative) about how light affects mitochondria.
Precisely... had just added a comment on this.
I really value my college physiology😊. And am thankful that there are no genetic issues in my kids and grandkids. We are all on organic foods, exercise, and avoid chemicals whenever possible. I would love to know how giving kids 90 vaccines is good for their mitochondria.
Wonder that too. About vaccine
@@endgamefond me too
90 ?
I have a mitochondrial disease MELAS.
Thank you for the info
Another amazing interview!!! Thanks so much for all you are doing for providing these cutting edge interviews @MetabolicMind! Blessings to you all!!!
IMO, this guy is really onto something big!
Absolutely incredibly fascinating. I wish I was a teenager so I could study this field at university.
Energetic changes in the body? I used to wake up in the morning very tired, then I started taking
Magnesium L-threonate, Magnesium Bisglycinate and Magnesium Taurate and now I have a lot more energy when I wake up and all day...I wonder if my mitochondria are happier because I am. I used to want to turn over and go back to sleep...
@brutalgeneric: thank you for your comment. That is actually helpful. I can easily obtain indirect sunlight. I live in the sunny southwest. I slather sunscreen on whenever I step outside. Perhaps in late afternoon going out without without the sunscreen for a walk would be an ideal way to get indirect sunlight. Very helpful tip.
Watched 5 times ... Thanks!
This is really great! Now please, please list for me how to keep these other organelles healthy, I am so worried I have no idea how to deal with them: my ribosomes, Golgi apparatus, lysosomes and I am particularly worried that I am not taking care of my endoplasmic reticulum.
Are you on a ketogenic diet?
Just eat a animal based diet....
❤ From Nepal
Amazing insight
This video should have been titled: “How to maintain and enhance your healthy mitochondrial function.” It is very good information within those limits. What it should NOT be seen as, is any kind of therapy or solutions for those who are suffering from Mitochondrial Dysfunction or disease.
Those people suffering from chronic low functioning mitochondria don’t need to hear very young Doctors telling them- “To Move!” when their bodies won’t let them get out of a chair much of the time. And I mean at the level where they might only be able to get out of that chair if the house is on fire. Or to “Eat Less!” when every natural signal in their bodies is telling them they are in fact starving from lack of nutrition because of their resultant lack of energy. Or, “Find Some Way to Feel HAPPY!” when their lives are being ground into a fine dust of failure by their inability to function in an even vaguely normal way.
For those people- understand that what you have here are two very young doctors, giddy with their first real world experience and information outside of University that makes them think they have answers. What this is Not, is well-grounded knowledge from decades of medical experience and maturity.
Well said 👏
Thank you for your comment, and we apologize if you were offended by this information. You are absolutely correct that this was not intended to address severe forms of mitochondrial diseases, and we should have been clear about that. This was meant to address those living with conditions that may be improved by focusing on the basics of mitochondrial health. As Dr. Picard mentions, this is an emerging field that we are continuing to learn much more about. But by no means is this a cure all for everyone, Again, we apologize if our purpose was misleading.
@@metabolicmind everyone being offended by non mainstream ideas nearly got me killed.
The previous interview episode, with Matthew Philips, still isn't showing in my Google Podcasts app, even though this more recent episode, with Martin Picard, is.
Thanks for notifying us! You should be able to see it on Google Podcasts now.
@@metabolicmind Yep - I’ve got it!
I've seen quite a bit of research pointing to Urolithin A as a supplement that can be beneficial to mitochondrial health. Of course, doing all of the things within our control makes the most sense, i.e. activity, sleep, good nutrition and developing positive mental health. As a 73 yo who has been told to take a statin drug, I am concerned about the potential negative effects on mitochondria.
That's where I am now they don't want us to use natural methods ,why is it big pharma ,or they have to follow rules ???? Look at ivamectin debacle,, that wasn't doctors,, that was state and we are nearly bankrupted by money makers , ,,politicians and big pharma we have become just a number,, for profit ,to some,,where is the human personal touch
Why a statin? Do you have insulinnresistance? Are you doing ketogenic diet already and ldl went up? Ldl is OK to be high, if had no heart attack, as long as triglycerides are low (from sugar in diet). If triglycerides are low insulin should be low. To me it's not what to take, it's how to manipulate food scarcity/eating and when and what to eat.
@@dana102083 My total cholesterol and the ratio of LDL to HDL is typically too high, but not extreme. Knock on wood, never had any heart issues or an attack. Good BP and RHR of about 58 to 60, Vegetarian. Lift and do HIIT 2 - 3 times per week and jiu jitsu 2 xs per week. I'm trying to improve my endurance in jiu jitsu and maintain good strength.
@@dana102083 please are you from Ontario.. Granny ran a retirement home? Thanks
i hope you are taking urolithin A? It’s expensive, but I have the impression that it is helping with my mitochondrial health
I like this one thanks
Love it 🔥
In regard to the experiments Dr. Picard mentioned in which mitochondrial networks within cultured cells became fragmented following an excessive supply of energy, it would be interesting to see this experiment repeated with variations in the type of energy source supplied (e.g., pure fat vs. pure carbs vs. fat and carbs in varying proportions) and with variations in the starting conditions of the cells (e.g., fat-adapted vs. not fat-adapted).
I wonder if HIIT , sprinting and such has a different effect on mitochondrial supply from aerobic training ? If we look at long distance runners compared to 100 meter runners the muscle growth is very different . Even looking at 200 meter vs 100 meter runners displays a massive difference. It seems reasonable to me that loooooooong distance running id depleting your energy where as with sprinting you seem to be energised once you catch your breath.
However I have inflicted Achilles tendonitis to on myself - mainly due to idiocy. I recommend lots of strength training of the Achilles area prior to sprinting . Especially if you are only young in your heart , mind and soul. ......
Rehab takes a long time weeks into months, but I can do Air Bike. No excuse.
Great interview, but no mention of the microbiome connection with the mitochondria. Correcting your microbiome forcefully though vegetables juice and fermented foods is essential, your carrying 4 kilos of bacteria ✨
I am going on two years of mitochondria damage due to two courses of Cipro for a gut infection. It has left me with ruptured tendons, brain fog, fatigue, worsened 34:08 food allergic reactions, visual disturbances, chronic pain, muscle weakness, neuropathy, among other things. I have spent a small fortune on supplements to repair the damage, but have reached a plateau of improvement and seem stuck. I forced myself to move even though I hurt everywhere. On crutches for six months, I now can walk three miles, force myself to climb stairs, but one leg drags and wobbles, dangerous when climbing stairs. I eat a healthy lowr calorie diet, avoid sugar, only use olive oil, organic produce and grains, little high fat animal protein, but my recovery has halted at this level. I tire easily, by evening am done in, and need to eat three meals a day. Fasting makes me sick. Is there a supplement that can stimulate new mitochondria production? I am coping, but frustrated that a doctor would prescribe such a toxic medication to treat an infection that a safer antibiotic would have worked. I am 74. Before the Cipro, I hiked 5 miles a day, was active socially, did creative writing projects, dabbled in learning to paint, and a lot of that has been put on the shelf. Just writing is difficult,putting thoughts in order, expressing myself clearly, is challenging . Memory loss worsens as the day progresses. I am determined to fully recover, I am not giving up. Any helpful advice is appreciated. Thanks.
You have drunken the koolaid and much of what has been suggested as “healthy” is actually incorrect.
You say you are low calorie-wrong as calorie counting isn’t helpful
You’ve cut sugar great.
How about carbs and grains?
You say you are eating organic produce and grains.
Fruits have fructose that cause non alcoholic fatty liver, veggies are fine if low carb. Organic grains??-thats nothing but carbs.
Then you say you limit high fat animal products. Wrong again. High saturated fat is beneficial for the human body. Cholesterol is a misnomer, the key metric is keeping insulin spikes less frequent and triglycerides levels low.
You are 74 and much of the knowledge you carry stems from the Food pyramid and guide which is mostly not based on science and only to support certain farming industries.
Try ketogenic to get carbs down.
Try learning about full carnivore to actually heal the body.
Cipro and any GI ailment is best treated with a low residue diet just as recommended to patients who have just had a GI surgery.
The ultimate elimination diet is ground beef, whole eggs, and a bit of avocado and mushroom.
Try that for a month and see how you feel. At this point you have nothing to lose other than disrupting the misinformation and cognitive dissonance from the brainwashing We have undergone since the 70s. I am over 50 and only changed my mind from knowledge gained on YT after personally being sick and inflamed, looking for answers.
Have you looked at the ketogenic diet info on this channel? It's backwards to what the food guide states. Grains aren't considered healthy, nor is little saturated fat! Not being a ble to fast is a good indicator your body is not able to use fat efficiently.currently and that needs to be challenged. I'd strongly.recommend ketogenic diet fornthat purpose as it adapts you to using fat and will take a few days to get into ketosis and allows for more autophagy while you're eating and will keep you full when not promoting longer fasting which in future can extend.
Grains are awful on the gut. Hands down that's the first step that needs to go. Low fat doesn't promote brain health. Literally fo opposite there's benefit over low fat and studies to show it!
High fat high salt
High animal fat and meat focus (1.2g/kg a day)
Eat low.carb veggies as long as you get minimum protein each day.
I have heds which affects all connective tissues and greatly.in the joints. I'm disabled from it and we avoid cipro as we already got issues there. I hear you, it really blows :( this helped me get.my energy and vigor for.life back. Looking at mitochondria is the right place and ketogenic diet is next step.
Thanks for your feedback. I do not know what nad iv is put will look it up. I am ready taking pqq. It has helped. The keto diet is a no go. I am highly allergic to most meats, and chlorophyll. Eggs, chicken, beef, pork, turkey, Buffalo, all make me swell and itch and cause bursitis. Fasting causes my blood sugar to plummet. Peanuts, almonds, other nuts also problematic. So the diet is restricted due to lifelong food allergies. Thank you for your considerate comment. All are appreciated.
Ketogenic diet can be a vegetarian diet with what ever foods you can tolerate as long as they are not processed. The key to the ketogenic diet is the proportion of fat has to be 65% or over. Choose high protein vegetables to make up the protein component but add vitamin and mineral supplements to a vegetarian or vegan diet. Do not forget vitamin b12 supplements. Hope this helps.
Also avoiding all sensitive foods for at least 3 months and try adding one at a time every 10 days if you want to try. You may need help from a dietician in order to go in an elimination diet.
I am so sorry to hear this. I think I would explore these possibilities if I were in your shoes. 1) A good, experienced kinesiologist. Kinesiology is both diagnostic and also shows what strengthens your body and what weakens it (including any supplements you're taking or that they are considering prescribing). 2) Eden Energy Medicine, now rebranding Eden Method. Again, a good, experienced practitioner can find out a tremendous amount about what's going on and rebalance your body's energies including deeper energy systems not covered by conventional medicine. Sessions can be done remotely by experienced practitioners if there's noone near you. Donna Eden can see energy and made a powerful recovery from MS decades ago. Her method incorporates elements of kinesiology. 3) A functional medicine practitioner with training in this area. 4) A good, experienced Chinese Medicine Doctor. The Chinese medicine system can deal successfully with many chronic conditions that Western medicine is at a loss as to what to do about, and has thousands of years of history behind it. The Emperor's physician used to only be paid if the Emperor was healthy! Wishing you well
Theres a whole machine with billions of moving parts that keeps us alive and moving. Forever amazing.
So interesting! This is a discussion I'll save to rewatch later.
Ok now I’m curious if stretching might also increase mitochondria. The reason is that, when I stretch often and feel more limber, I find that my endurance seems to be a little greater. Stretching only directly before a workout doesn’t seem to have the same impact.
How interesting!
💚👍
Thank you for sharing your experience with stretching and endurance