Supplements For Mitochondrial & Muscle Health | Dr Sandra Kaufmann Series 2 Ep2
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- เผยแพร่เมื่อ 7 มิ.ย. 2024
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This video brought to you by BiOptimizers.
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In this video Dr Kaufmann introduces talks about mitochondria and keeping them healthy and also maintaining muscle. We also touch on blood glucose levels and natural SGL2 inhibitors.
00:00 Supplements for mitochondria
03:55 Ellagic acid and urolithin A
04:50 Mitochondrial uncouplers
06:57 Sarcopenia and muscle maintenance
09:21 Leucine's metabolic impact
10:13 What is my protein source
11:19 Monitoring glucose levels
Sandra Kaufmann, is a cell biologist who for the last seven years has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. She is also the founder of the Kaufmann Antiaging Institute and the author of two books, The Kaufmann Protocol: Why We Age and How to Stop It and her new book, The Kaufmann Protocol: Aging Solutions. In the books she describes the mechanisms of aging on a cellular level and provides details on many of the supplements that we can use to slow it down.
🌐Dr Kaufmann's web site kaufmannprotocol.com/
📚Dr Kaufmann's books on Amazon
The Kaufmann Protocol: Aging Solutions amzn.to/3Typ41x
The Kaufmann Protocol: Why we Age and How to Stop it amzn.to/3yWnEEo
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Other Supplements that we take
First thing in the morning
Vitamin C 1g - California Gold Nutrition iherb.co/tjmJCSKv
D3/K2 - Thorne - iherb.co/GYkP4T5b
Life Extension, BioActive, Folate & Vitamin B12, 90 Vegetarian Capsule iherb.co/viDytpH
Renue By Science, Liposomal CaAKG 90 300mg capsules - tinyurl.com/29j5pfcd
Renue By Science, Lipsomal Glutathione 90 130mg capsules - tinyurl.com/yc6dxk34
Equal Exchange, Organic Coffee, French Roast, Whole Bean, 10 oz (283.5 g)
iherb.co/hqfF23y
#DrKaufmann #leucine #sirt3 - วิทยาศาสตร์และเทคโนโลยี
Thank u, Richard, for inviting educated and knowledgeable people like Sandra - definitely buying her book, her site also offers a ton of useful information 😊🙏
Great interview! Great guest and I appreciate that you provided a framework for the interview and then minimized interruptions.
I'm so thankful for you. I have learned so much from you and your guests. I really appreciate it.
Hi Ravi, thank you for your kind comment. It is very encouraging to know that we are helping spread information!
I have ordered her new book, The Kaufmann Protocol: Aging Solutions. Thanks for this series.
Hi Thanks! Great to hear.
The fat redistribution property of Pioglitazone sounds brilliant. I immediately looked it up on the internet, and unfortunately, found quite a few contraindications. Sounds tempting, none the less. Excellent video interview. I learned a lot.
I take an amino acid formula with leucine as the 1st ingredient. I maintain good muscle mass even though I don't work out alot. I am 63.
I like how she broke so much down in less than 15 minutes! I will definitely be buying her book!
Magnesium Break Through 10% Discount bit.ly/3O5tPfu
The Kaufmann Protocol: Aging Solutions _amzn.to/3Typ41x_
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Magnesium breakthrough was great for me in the beginning, but ultimately only taking capsule in the evening, the benefit was dismissed and I had no energy, I was dragging and had to stop. I now use Mitopure and NMN +, Resveratol. So far, so good. Oh, can't forget Turmeric with Xanthanthin
3: magnolia, hung over mornings, melatonin
2. NAD precursor
3. NRF2: astazanthe
4. Pclutozoine
Pioglitazone?
By the way, NRF2 can be activated by sulforophane from what I hear. I didn't get the name of the hangover medicine. Also, I am not so sure about Pclutozoine. Was that an actual recommendation or rather just part of a mechanism discussion?
It’s pioglitazone and don’t take it as it’s a prescription diabetic medication. Don’t listen to any crap on TH-cam and research everything. These people do Botox and fillers and then go around as anti-aging gurus.
I would ignore 80% of what she says as BS.
@@mreudeco why. Which 80%?
Richard can you list by name these products thank you
This is the most valuable video I have watched in a while (and I watch a lot of anti-aging/health/body building videos). I too am into stimulating mTOR for my body building goals even though it is supposedly not good from an anti-aging perspective (my strategy is 3 days a week mTOR stimulation and 4 days focus on autophagy and DNA repair). I knew about NMN and Leucine but was unaware of Melatonin's activation of the sirtuins and had never heard if ursolic acid. I have just ordered some ursolic acid and will also add melatonin to my supplement regimen.
Hi Doff, thanks for sharing and your kind comments
@@ModernHealthspan It's the least I could do. Just finished reading your book the Kaufmann Protocol and will go looking for your latest book. I have just added Astaxanthin to my protocol too.
Call this video was so in lighting to know I was so interested because I have no strength on my left side because I have had a stroke. I need something for my brain so I can wake it up a bit stem cells ,. God I love this videos good .. plus I need is something for my muscles so bad to be strengthened stronger
I want these books from Sandra. I want to have those organized charts. Richard, you are looking so much younger lately.
Hi thanks for your kind comments!
Dr. Kaufmann is incredible. She needs to be more present in social media.
She really is very knowledgeable
Thanks Richard.
Hi Ron, thanks!
Oh... and Yes, Leucine does boost NAD precursors, together with Resveratrol, don't take too high of a dose, and it will not activate mTOR...
I take them all 3 at once...😉
Hi Om, thanks for sharing. That does sound good and we just talked to Dr Zemel about leucine in more detail.
@@ModernHealthspan Yes. Thanks. There is where I got the idea. Your work is very much appreciated!! Please don't stop!!👍👍
But I do not like leucine I like valin better milk thistle potassium chloride
Astaxanthin, Magnolia... very interesting, I was dismissing their importance to a secondary or even tertiary category, but now bumping them up on my list...
- Though I think we need to take all this "stuff" intermittently... the body needs to do its part as well...🤔😎👍
Hi Om, thanks for sharing. I agree, I tend to have a core set of supplements that I take everyday and then others which I rotate through.
@4:30 referring to ellagic acid, she says "...as you break the pieces up they become the urolithins..." Well, isn't Uro-A made in part, in some people, by gut bacteria consuming ellagic acid (and other polyphenols) and making Uro-A? Julie Anderson PhD (Buck) and Dr. Singh former guest on MH are just two relative experts on Uro-A.
Hi Peter, thanks for your comment. That is my understanding as well. Dr Kaufmann did not go into how ellagic acid was broken up into the urolithins so the two are not in disagreement per se. Though if you don't have the right microbiome, according to Dr Singh, you won't get any urolithin A from taking ellagic acid.
The thing that jumped out at me in this video was that, though Dr. Kaufmann prioritizes muscle building - or at least maintenance - she still takes Metformin and Berberine, which, as I understand it, activate AMPK, which is antagonistic to muscle-building MTor. I just received a supplement from Renue by Science called Defender, which has CaAKG, Berberine and HLA, and I was starting to think I shouldn't have ordered it because of the Berberine, since I do a lot of muscle building and certainly would not trade muscle loss for longevity. Since Dr. Kaufmann doesn't seem to worry that Metformin (which thumbing through her book, I see she mentions though she doesn't seem to mention Berberine) will deplete muscle, I feel more confident that I can take Defender without worrying, either. Berberine has its benefits (especially for diabetics like me), so I'm happy I can take it without, presumably, suffering muscle loss.
Richard, You and some of your followers have some expertise on magnesium supplementation. Do you have an opinion on taking magnesium L-threonate before bedtime? It is supposed to penetrate BBB better without overloading your intake. Thanks.
I am waaaaaaaaaay too tired to go on trying to make heads or tails of all this info. I understand it's important but frankly I am burnt out trying to figure out exactly WHAT I should be taking, WHAT I should avoid, HOW MUCH of what substance is good/bad etc etc. PLEASE PUT IT IN LAYMAN'S TERMS. TELL ME WHAT TO DO. I DON'T NEED ANY MORE STRESSING ABOUT WHAT WORKS AND WHAT DOESN'T.
I understand, and granted, there's certainly a lot of information to sift through concerning health in general. But it's definitely worth the time and effort invested. Any beneficial changes in your health, however small, are still a win and will enhance the quality of your life in some way. Keep going in your search to improve your health. It's all worth it. Best of health, be well.
So astaxanthin activate NRF2? what minimum dosage is enough to activate NRF2?
Antioxidants in supplement form blunts exercise adaption (vo2 max and hypertrophy) if taken the day of or within 12 hours after exercise, vitamin C, coq10, Vitamin a and e, resveratrol all blunt exercise adaption enzymatic pathways
5:48 - BEWARE - the product Richard is promoting has a product information page that is not scientifically sound. There are five main problems:
1) It lists all the forms in the product, but the first one: “magnesium chelate” isn’t an ingredient in the way the other 6 are.
Chelation is how some organic molecules bind to metal ions using ligands to form stable complexes that are different to salts.
In other words, there are only 6 forms of magnesium in Bioptimizers formulation *not* 7 and most of them are magnesium chelates.
2) Magnesium sucrosomial is a proprietary compound and I was unable to determine its structure. The issue with this are safety and efficacy concerns, because any new compound requires rigorous testing followed by a long period of post-marketing surveillance before it can be deemed ‘safe’. I’m not convinced this has been done with sucrosomial.
3) With so many different ingredients going into this product, maintaining quality control is a problem, because it only takes one dodgy batch from just one ingredient to void the entire batch of Bioptimizer Mg…but just how good are their quality control processes? I could not find any kind of third party quality assurance nor GMP accreditation…does not inspire confidence that they’re producing a high quality product.
4) There is no information about the absolute amounts of each magnesium compound in their product, so you’re getting a cocktail and you don’t know how much of any ingredient you’re getting? Dovetails with (3) to not inspire confidence.
5) It talks about getting *all* 7 forms of magnesium in one capsule, but what does it mean by *all*?
It seems to be making the claim that these are the *only* forms of magnesium you can buy. Blatantly not true, but even if you limit their claim to just organic chelates of magnesium, then what about: acetyltaurate, L-threonate, or lysinate?
Lastly, I’ve been a subscriber of Richard since his channel was called: Modern Healthy HK. You would’ve thought he would have learned the basics of longevity by now, but I’m sorry…no way I can trust the judgement of someone who still can’t pronounce ‘mitochondria’ after all these years.
Richard, it’s ‘mite’-o-chondria, not ‘meet’-o-chondria!
Is there a transcript of this show? That would be very helpful. Is she saying that keeping blood sugar down is good for mitochondria? So wouldn't simply following a low GL diet do the trick? A low glycemic load diet also gradually rejuvenates the pancreas. Seems to me that a low GL diet is fundamental to health span.
what you have to tell us about PQQ !???
HMB is an anti-catabolite for muscle, it is a metabolic byproduct of BCAA but not in sufficient quantity so a supplement is suggested. It prevent the breakdown of muscle and promotes muscle healing.
But the liquid form is important
@amma Lea laura chemically I don't see why it matters. However I think in capsules it's easier to control the dosage. I also take so many supplements at the same time I find it more convenient to swallow capsules. I probably take over 60 kinds a day with more coming.
@@markfischer3626 because it is with calcium this ages you and the liquid form with butyrate is good for your gut
@@Schutzmassnahmen the amount of calcium is miniscule and I take other supplements for butyrate like GABA and other supplements for gut health. I'm over 100 different types of supplements now.
And Im getting closer to 70
Nice .. very interesting… with humor .. a rockclimber … Well pity i just gave up my Amazon Account … Now i cannot get to the books. 😢
Hi thanks for your comment and yes she is great. I am sure you can get her book from local bookstores as well😁!
I am in Europe … difficult . But you asked some nice questions and she gave a good overview.
At min 11:35 she mentiones a supplement for boosting pcg1a and lowering glucose level. I understood smthg like piaglutazion..
Can someone pls tell me tge exact name? Thanks!
Hi Justus, thanks for the question. The substance was Pioglitazone. Unfortunately now I look it up, I see that it is a drug not a supplement.
She days something like "sirt 3 is the only sirtuin known to be associated with longevity"..?
That seems pretty dubious.. What about Sirt 1 & 6?
You guys ever hear of melatonin supplements causing damage to the eye ? Thanks
Vitamin e tocotrienols
Hi Richard, agree with a lot of what she says, but saying SIRT3 is the most important sirtuin is controversial and I believe untrue. Sinclair, Gorbunova, and many other leading researchers all agree SIRT6 is the most important sirtuin for longevity. Would be happy to speak to Sandra and see what data she is looking at.
Keep the good interviews coming!
What they said is that SIRT3 is the one we know most about, and Sinclair and company have said it is the most important one, and SIRT6 might be more important, but we don't know much about it yet....
But, who cares?? Take the "stuff", live healthy and happy... oh, and longer...🙂👍
@@omvilla7469 well then she is wrong. Direct quote from David:
"SIRT6 seems to be the most potent/important because when you turn it on you get a robust lifespan extension."
@@alangraves1189 with emphasis on "seems to be"...🙄
Hi Alan, thanks for sharing and great to see you! Certainly I have heard more about SIRT6 in longevity and it is the one I believe has the most research behind it.
She said Sirt 3 was the most important sirtuin related to mitochondrial health.
He had it all and threw it away
So im confused... Can we fast with leucine and stimm stimulate ampk or not?
After watching this and dr zemels intervew Im now confused about leucine. Does it stimulate mtor by itself or not? From dr zemels interview it sounds like leucine is more of a mediator that can power either ampk or mtor depending on what its paired with. And also that leucine wasnt powerful enough to spike mtor without a large amount of protein.
Im fasted today(or at least i thought i was) hoping to stimulate ampk. I dont usually take leucine until the evening with my first meal when im fasted. After watching dr zemels interview a couple days ago. I took it with my niacin this morning. Did i end up stimulating mtor and breaking my fast?
i couldn't make out the supplement that Dr. Kaufman said to take for burning brown fat~is that different than solid fat? Within your organs?
You don't burn brown fat. Instead some white fat cells start to have a high mitochondria population, which turns them brown. They are still burning white fat *molecules* but they are doing it faster.
Dr. Greger has a long list of foods and spices that help turn fat cells beige (adult cells probably don't go full brown) in his book "How not to Diet".
@@jefflittle8913 Thanks for replying. Yvisceral fat?
Dihydromyrecetin
Hi Julia, thanks for sharing. I had not heard of that supplement before. It is also called ampelopsin.
Thnx! What was that one for?
It is taken to repair liver mitochondria. But how do u take it? Its not soluble in water or fat. Its only soluble in alcohol. If someone is not drinking alcohol, what is the best time to take Dihydromyricetin? Is it better to take Urolithin A instead of DHM for non drinkers? Can someone please answer?
@@ModernHealthspan can u please answer above question?
There is no general manager on a job site. there is a general contractor
Hi Richard - this dr sounds smart but then not up to date on rapamycin with her comment that not good for muscle growth. Much testing over past couple yrs with use of rapamycin once ever 7 to 10 days then not detrimental effect on muscles and probably even some benefits to muscles and then too the biggest benefit for autophagy for one day taking drug. Too, much research from the NIH testing program (ITP) on really only several supplements with any real benefits for mice longevity and the dr having many recommended showing no benefits here with ITP for mice. If no benefit in mice for longevity then unlikely to benefit humans. Too the doctor mentions she eats junk processed foods and needing several drugs from her health issues with potentially some from all the junk food. After listening no desire to get her book. Thanks for the interview though and always looking forward to your new interviews and updates. Mike
the last portion , she mention natural ingredients , but never say the exact ones.
Type phlorizin SGL2 into Pubmed. The flozin drugs are derivatives of phlorizin. Phlorizin is not a practical solution as it is not available retail.
Hi Brandon, thanks for the question. I thought that the one she mentioned was a supplement (Dapagliflozin) but it is drug. Looking around I cannot find any supplements that have this effect (unfortunately).
This is discussed in Yaribeygi 2022, Naturally Occurring SGLT2 Inhibitors: A Review , I found citations 35 onward interesting.
Melatonin makes me nauseated bigtime.
red / IR light therapy and / or good sun exposure will produce melatonin directly within the mitochondria, within the cells , where it is needed and during the day when oral melatonin is going to disturb your sleep cycle. At night the brain produces melatonin not just for sleep, but for the cells as well. This video by a licenced physician will explain in more detail, with a summary @22 th-cam.com/video/2Zzo4SJopcY/w-d-xo.html
Take it in cream and watch your vitamin d3 k1 k2 vitamin a
For mitochondrial health eat beef and/or liver.
Commercials!
Taking drugs to lower bloodsugar??? Cheeting your system (= your body) with medications??? Would it not be more logic to NOT eat sugar and fast so now and then? More natural. I will never take medications for this. Richard, do you agree with this practice? Why didn't you object?
You’re wrong here. I take vitamins and supplements also Dr Ken Berry agrees with taking them same with Dr Eric Westman. Along with my cardiologist. Down 87lbs in under a year, my labs are perfect my bone mass is fine through a dexa scan I had. Don’t knock what you don’t know.
You dont argue with a guest you are interviewing. It isnt a debate, you asked to get the guests view. She said she never recommends her own diet. She was honest
@@TheBwithers Well I think a debate would make it even more interesting.
Hi Kristi thanks for your comment and question. So, two parts: Do I agree? I guess I view it this way. I make calculations of risk/reward all the time. I could eat cleaner, avoid all alcohol etc. but I enjoy these things and consider the trade off worth while. Dr Kaufmann makes an informed choice as to what she likes and takes measures to mitigate the outcome. I think this is a valid choice for her to make.
With respect to whether I should push back on people. There are a couple of things, 1) in general the people I interview have a much deeper knowledge in the topics than I do and I may ask for clarification or or raise questions but it is not a debate . 2) I don't agree with everything that people who come on the channel say. For diet for example, I have had vegans, keto diet proponents and people in the middle. It would be impossible for me to agree with everything all of the say as they don't agree with each other!
@@ModernHealthspan Hi Richard! Oké I understand your point. Just one thing: When it comes to advice to take drugs, you and your guests should warn people for the possible side effects. Many people follow the leader, follow you and your guests, without critical mind. You have to protect them from side effects and point out that a healthy lifestyle is always better than hacking your system with drugs.
Meat for Meatochondrial health. 😀 Seriously, keto diet and fasting are the best ways.
Depends on what you're dealing with. If you have autoimmune stuff or APOE4:gene or MS food alone is not working. Your body is not using some things correctly so some supplements are helpful. I lost all excess weight to BMI 21 and insulin resistance is still there. I'm transitioning to anti inflammatory diet but energy is getting bad. Researching takes so long too. But glad to get the info and comments and sift through.
She is Stunningly Beautiful! Great info.