vol.1/3) Hormone Therapy for Prostate Cancer? : Remember Androgen Metabolic Pathway.

This 8-minute video is for medical students, packed with insights on prostate cancer care and hormone therapy.
#prostatecancertreatment #hormonetherapy #pharmacology
【Study Break Oasis】
5-Min Forest Oasis: Healing Sounds for Study Stress
• 5-Min Forest Oasis: He...
5-Min Seaside Serenity: Waves of Calmness for Study Stress
• 5-Min Seaside Serenity...
【Learn about Hormone Therapy For Prostate Cancer】
vol 1/3) Why is Hormone Therapy used for Prostate Cancer?
• vol.1/3) Hormone Thera...
vol 2/3) Androgen Receptor and Androgen Synthesis
Abiraterone (ZYTIGA®, Yonsa®), Ketoconazol (Nizoral®), Flutamide (Eulexin®), Bicalutamide (Casodex®)., Mechanism
• vol.2/3) CYP 17 inhibi...
vol 3/3) LH-RH agonist or antagnist?
Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®), Degarelix (Firmagon®), Mechanism
• vol.3/3) LH-RH Agonist...
【Learn about Hormone Therapy for Breast Cancer】
vol 1/4) Why is Hormone Therapy used for Breast cancer?
• vol.1/4) What is Hormo...
vol 2/4) SERMs: Tamoxifen (Nolvadex®, Soltamox®), Raloxifene (Evista®)
• vol.2/4) What is SERMs?
vol 3/4) Aromatase inhibitors: Anastrozole (Arimidex®), Letrozole (Femara®), Exemestane (Aromasin®),
• vol.3/4) Do you know t...
vol 4/4) LH-RH agonist: Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®)
• vol.4/4) LH-RH Agonist...
Explore and master the essentials.
#prostatecancertreatment #hormonetherapy #pharmacology
【Notes】
▹This video was created based on data as of April 2024, with the purpose of supporting medical students in their exam preparations.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Reference and figure】 I express my gratitude and respect for your wonderful achievements.
1. Mills, I. Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. Nat Rev Cancer 14, 187-198 (2014).
doi.org/10.103...
2. Watson, P., Arora, V. & Sawyers, C. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat Rev Cancer 15, 701-711 (2015). doi.org/10.103...
3. Naamneh Elzenaty R, du Toit T, Flück CE. Basics of androgen synthesis and action. Best Pract Res Clin Endocrinol Metab. 2022 Jul;36(4):101665. doi: 10.1016/j.beem.2022.101665. Epub 2022 May 6. PMID: 35595638.
4. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Flutamide. [Updated 2023 Mar 15]. Available from: www.ncbi.nlm.n...
5. DrugBank online, Bicalutamide, DB01128,
go.drugbank.co...
6. Fagerlund A, Cormio L, Palangi L, Lewin R, Santanelli di Pompeo F, Elander A, Selvaggi G. Gynecomastia in Patients with Prostate Cancer: A Systematic Review. PLoS One. 2015 Aug 26;10(8):e0136094. doi: 10.1371/journal.pone.0136094. PMID: 26308532; PMCID: PMC4550398.
7. Biernacka-Łukanty JM, Lehmann TP, Trzeciak WH. Inhibition of CYP17 expression by adrenal androgens and transforming growth factor beta in adrenocortical cells. Acta Biochim Pol. 2004;51(4):907-17. PMID: 15625562.
8. Zhu X, Wu S. Risk of hypertension in Cancer patients treated with Abiraterone: a meta-analysis. Clin Hypertens. 2019 Apr 1;25:5. doi: 10.1186/s40885-019-0110-3. PMID: 30984412; PMCID: PMC6442407.
9. Clinton TN, Woldu SL, Raj GV. Degarelix versus luteinizing hormone-releasing hormone agonists for the treatment of prostate cancer. Expert Opin Pharmacother. 2017 Jun;18(8):825-832. doi: 10.1080/14656566.2017.1328056. Epub 2017 May 19. PMID: 28480768; PMCID: PMC7171911.
10. NIH National Cancer Institute, Hormone Therapy for Prostate cancer.
www.cancer.gov...
11. Bernard Jégou, Antoine D. Rolland, Sertoli Cell, Editor(s): Michael K. Skinner, Encyclopedia of Reproduction (Second Edition), Academic Press, 2018, Pages 24-27, ISBN 9780128151457,
doi.org/10.101....
(www.sciencedir...)
12. Aladamat N, Tadi P. Histology, Leydig Cells. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: www.ncbi.nlm.n...

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I fell asleep watching my video, so I made it shorter.