So does the intermediate contain a phosphate group, or does the energy released from the conversion of intermediate to pyruvate allow inorganic phosphate ions already present in the cytoplasm to bind to the ADP molecules? and at what stage is the phosphate group originally added to glucose removed by ADP, in the triose p to intermediate stage or intermediate to pyruvate stage? But only two P groups are added so how does 4ATP get produced?
All the ADP phosphorylations (substrate level phosphorylations, ATP production ) happen by transfer of phosphate from three carbon intermediates to ADP. There are actually two phosphorylation events adding phosphates to the sugar in the glycolysis first stage. This results in two, double phosphorylated 3-carbon molecules (in the first stage) ie four phosphate groups altogether at the halfway stage. I know this is strange because that second pair of phosphates don’t come from ATP, and so we get two double phosphorylated 3-carbon molecules even though we only used two ATPs. In the second stage, each of these four phosphate groups is transferred to an ADP, resulting in 4 ATPs made: two in the production of the intermediate, and then two again in the final production of pyruvate. I hope this helps. Let me know if it doesn’t. Good question.
I looked into the more detailed version of glycolysis on the internet and in it, it says there's also in total 2 molecules of water made during one of the intermediate steps. If that is the case, why do we not count water as one of the products of glycolysis? Thanks :)
+Noor-ul-huda W I'm not sure about the production of water. But let's assume it's true, I would say because we only consider the molecules that have a functional purpose ie ATP, NADH for subsequent steps, pyruvate for subsequent steps etc. What could we say about water?
SIR. one question i thick that the intermadiates mentioned should contain another Pi group to be able to produce the ATP at the arrow over pyruvate isn't it??
+marrier daryl The two ADP phosphorylations (for each triose phosphate) are done by transferring phosphate from the triose phosphate to ADP. You are right that two phosphates need to be added into the reactions so that we end up with two ATP produced per triose phosphate molecule.
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never in my years of learning bio did i ever think it was easy to memorise until i watched your videos, thank you so much for these!
please keep make videos , they are very very helpful to many students. thanks for your help and efforts.
+Preet Kaur glad to help!
honestly so grateful for your videos!!! thank you so muchh
Thank very much for your videos, thus far they have really helped me get a better picture and hence much easier to remember the concepts
Thank you ! My teacher couldn't explain it very well :)
So does the intermediate contain a phosphate group, or does the energy released from the conversion of intermediate to pyruvate allow inorganic phosphate ions already present in the cytoplasm to bind to the ADP molecules? and at what stage is the phosphate group originally added to glucose removed by ADP, in the triose p to intermediate stage or intermediate to pyruvate stage? But only two P groups are added so how does 4ATP get produced?
All the ADP phosphorylations (substrate level phosphorylations, ATP production ) happen by transfer of phosphate from three carbon intermediates to ADP. There are actually two phosphorylation events adding phosphates to the sugar in the glycolysis first stage. This results in two, double phosphorylated 3-carbon molecules (in the first stage) ie four phosphate groups altogether at the halfway stage. I know this is strange because that second pair of phosphates don’t come from ATP, and so we get two double phosphorylated 3-carbon molecules even though we only used two ATPs. In the second stage, each of these four phosphate groups is transferred to an ADP, resulting in 4 ATPs made: two in the production of the intermediate, and then two again in the final production of pyruvate. I hope this helps. Let me know if it doesn’t. Good question.
Thank you. I understand it now.
Is the intermediate compound 'GP' ? Doing the f214 on the 16th and your channel seems v helpful! Can't wait to watch the rest!
ak28 _x did u pass?
I looked into the more detailed version of glycolysis on the internet and in it, it says there's also in total 2 molecules of water made during one of the intermediate steps. If that is the case, why do we not count water as one of the products of glycolysis? Thanks :)
+Noor-ul-huda W I'm not sure about the production of water. But let's assume it's true, I would say because we only consider the molecules that have a functional purpose ie ATP, NADH for subsequent steps, pyruvate for subsequent steps etc. What could we say about water?
SIR. one question i thick that the intermadiates mentioned should contain another Pi group to be able to produce the ATP at the arrow over pyruvate isn't it??
+marrier daryl The two ADP phosphorylations (for each triose phosphate) are done by transferring phosphate from the triose phosphate to ADP. You are right that two phosphates need to be added into the reactions so that we end up with two ATP produced per triose phosphate molecule.
thx sir... it's much clear now.. continue like this great work boss
Where is the link reaction video ?
I believe it is with the Kreb's cycle vid.
Dr Bhavsar literally just watched it and realised 😂
I'm having to watch these videos for uni😭