Here are the timestamps. Please check out our sponsors to support this podcast. 0:00 - Introduction & sponsor mentions: - Onnit: lexfridman.com/onnit to get up to 10% off - Clear: clearme.com/lexpod and use code LexPod to get 2 months free - National Instruments (NI): www.ni.com/perspectives - SimpliSafe: simplisafe.com/lex and use code LEX to get a free security camera - Linode: linode.com/lex to get $100 free credit 1:34 - Staying young at heart 5:30 - Bringing people back to life 11:05 - Wearables and tracking health data 20:18 - How to solve aging 30:22 - Why do we age? 35:50 - Genetic reset switch that reverses aging 38:20 - AI in biology 40:52 - Health data 48:58 - Fasting 56:29 - Diet 1:04:40 - Exercise 1:10:01 - Sleep 1:18:29 - Data 1:24:00 - Extending lifespan 1:26:42 - Immortality 1:32:28 - Denial of death 1:35:45 - Meaning of life without death
Howdy Lex! Great work on you definitely being a true solider of Love!! Good job man. Love is stronger, am hoping more folks understand this, join the consciousnesses. One of the best podcast series ever..yours. imo T h a n k Y o u
"I think doctors sometimes have a bit of an ego". You bet, it shuts down their curiosity and limits their knowledge. All from cannabis, psychedelics, NDE's, the ignorance of viewing the mind and body as one thing and not separate things, diet, etc, etc. It basically makes them incompetent. And it leads to great suffering for a lot of people.
@@WacKEDmaN you dont even know what he is doing , he has said we will die , only that the suffering and pain will be less because he will keep our body as healthy as possible , and living for 1000s of years wont be happening anytime soon , till then we would have found all the extra resources we are gonna need , also not necessary that everyone is going to choose to live for 1000s of years , most of us will get bored about a 100 and decide for euthanasia .
I am 67, I lost my brother, the last immediate family member, last year. Suddenly, I have a keen desire to live well into my 90s if not longer. For the first time in my life, I am almost afraid of dying, that, if this is it, I want to experience as much as I can for as long as I can. Thank you Lex and David for a little light in the darkness.
You are a very fortunate man to have lived to 67. I am 37 and facing a health problem Ive never faced before. Im wishing I could live for 10 more years, let alone 30 more. Have you not accepted Death, even at your age?
@@chukim8012 83% of Americans take at least one prescription medication a day. I do not take any, I just reshingled my roof alone. I work at a job I love and will continue to do so into my mid 70s. I have understand Death so in that respect I accept it, but fear the thought of premature death based on how I feel today. I have decided to live as if there is a God even though I have no evidence of that existence. That final thought prepares me for the acceptance you ask about.
I have a sale men selling watch Spair part one day I go buy some parts and take some times I told him I go have a smoke while you find my order he said do you think how old I am I said 65-70 he say I am 104 years old never drink alcohol and mom and any and smoke you see me I was amazed how never see working and physically very active so we just take care ourselves and this info at help is more an those have health problems number one is often eat less more fasting more destroy all viruses in our body even high blood pressure and stop sugar
@@rolandconnor575 the evidence simply seems that we exist consciously. that life is even life. let alone the ability to personally relate to this magnificent creating 'parent', one on one, heart to heart.
This was difficult and painful to watch, as my wife and I just lost our son, an only child, to sudden heart failure, on May 2, at 44 years old, leaving a 15 year old daughter. We are both 76 years old. Daniel and his daughter enjoyed time together, walking and talking about issues, gaming, cooking, etc. Still, I am glad that I watched it, and I surely would have shared the link with him, even though we both had Lex on our subscribe list. It pains me to discover that we are on the verge of wearing sensors that would have likely seen the heart failure signs far enough in advance to save him. Daniel worked IT at the University of Michigan, Medical Services, helping to keep all of the software and hardware issues fixed. I am crying once again as I write this.
I know it's been a while since you wrote this, but I'm so sorry for your loss. Your son sounds like an amazing person. I have an only child who is about to leave for college and I can't imagine what I would do if I lost her. I'm glad a part of your son lives on in your granddaughter and hope that brings you comfort. ❤️
I am so sorry for your loss. The pain you both have to bear is unimaginable, and I pray that your grandaughter, as a part of him, brings you some solace, as she matures into a woman. I am your age and widowed, with an only son aged 51. To lose him would be to lose a part of myself.
Aubrey de Grey is pretty cool to listen to if you like the longevity space. He'd probably also have something new to say but he's regularlu being interviewed on smaller podcasts 1-2x a week
@@spenser6353 you're delusional. He literally said many times immortality is basically impossible biologically and he also said he knows he's not going to live forever.
Until I heard the this episode I had a definite idea that the contemplation that we are mortals inherently drives meaning to our every moment. I took assurance from the Greek mythology where said that gods are abusing humans because they are jealous of our mortality, as they, the Gods, have meaningless existence because they can’t die. But now, after hearing this episode I realize that contemplating of living forever is IDENTICAL to the contemplation that we are going to die, and that it gives THE SAME meaning to every moment. Because both give time no meaning. Think about that: if you live forever what is the meaning of delaying to tomorrow? Time has no meaning. Tomorrow is identical to today. So when time has no meaning, it’s critical to make the maximum of every moment. Not because it will not come back (mortals meaning of life), but because you can’t escape your eternal present (immortals meaning of life). Thank you Lex and David for this existential epiphany.
I so agree with Lex when he talks about doctors being pretty much negligent about collecting datas, and often doing diagnostics based on %. I'm 38 now, training a lot, and running (did half marathons and marathon). I've been on antidepressants for 10 years, I stopped this year. It's a struggle, been I'm trying to be living naturally. I've been given meds but never have they check for my testosterone levels and other potential key elements that contributes to anxiety and depression. This video inspire me To work on staying healthy and trying to be stress free.
Lex, David, you both operate on the level where I’d like to be. This conversation embodies so much of my goals and practices. I can do it for hours, sometimes a few days, but I have a long way to go making it a constant stream. Yet, being right here doing these things, it feels like being at the forefront with you guys. It feels like support. Thank you both.
David got me interested in longevity. Aubrey de Grey showed me that we know what to do to reverse the hallmarks of aging. I hope you invite Aubrey onto the podcasts as well!
Aubrey de Grey is the legend of the longevity field - his role is drastically underappreciated by most outside the industry, because he doesn't interview as widely.
2:58 I love that Lex read this poem! I have vivid memories or reading that poem when I was 6 years old proudly to my mother...and then reading it silently to myself and feeling quite proud of how I had grown. 6 really is the BEST age. The age full of wonder, when you first start to peice the world together and search for your place in it.
Couldn't have come at a better time! I've been waiting for David to be back on JRE, but having him appear here is arguably an even better treat. Thanks Lex!
Huge thanks to Lex for having David on the podcast! It was EPIC! I interview healthy life extension enthusiasts, host Lifespan News and I'm the CEO/co-founder of Longevity Plan. I'm super focused on solving the human aging problem ASAP!
I think it's really worth mentioning Lex' improvement as an interviewer. I LOVED his philosophical rants while giving his guest a break in speaking and thinking. Really professional! 🙏🏼💯
This conversation was a work of art. I was going to say some of the podcasts have got a bit long recently, and that this one was nice for being a more digestible size, but I think my view on this is uninteresting, the three hour talk with your dad was amazing lex, thank you and much love.
This is probably my favourite ever podcast. Could listen to these two all day. I can’t remember the last time I questioned my perspective so many times in a short amount of time 😂
@@kevyt3095 That is the main issue. Nowadays most people seem to be living little bit longer than they wish. But there is no easy exit, if you cannot travel to Switzerland.
@@matyas_laczko Yes the freedom to do and say what you please. America is the most free country in the world, much more so then Canada where I am from.
Wow awesome interview Lex. Seen many interviews with Dr. Sinclair but you really killed it with this and got him to open up about much more, with your great questions and extensive research.
Well thank you Lex for being a very intelligent and adequate host. It is rare because David participates in many streams and shows and there's always a host who is trying to be smart enough to match David. You did not try that - you just were yourself. This is a token of utmost professionalism.
@@krisamagus1 well, funny is an aesthetic category, it's individual, so you do you. For me shitposting is a part of fun, it's what I do to amuse myself during a long work day. AND on my weekends. It's my hobby. I'm a bit bored AND very textually fixated, so sometimes I am guilty of leaving more than one comment on a video, this one is quite engaging after all. You could try testing your hypothesis before jumping to conclusions. I could say that you made that comment because you are 12, or because your wife doesn't give head. I could, but I won't because it conflicts with my main theory- you've got a huge brain tumor that's going to kill you in a matter of days, so you cling onto life and try to make up for all those years you wasted playing roblox by writing to a random guy and saying that you don't like his comment. It doesn't make sense, but less and less things do as the tumor grows. Black and white shapes sёём то маке seиse ьut тнеу gеt less and гёss familiar as you яeadd them. Шнат аяе тнеу? Геттерс? Геttёясс? Шнат does it all mean? You panic, because suddenly it goes back to normaг, iт sёёмs somewhaт иоямаг... Уоця degяадатион iз инэвитбл. Your рiиеаг gгаиd sёсяетs dёaтн ноямоиеssчлвщooOHмmMY GOD AM I DYINGовзыхыгаовш I DOИТ ШАИИА DIЕыоГвовоОвиыгТщылттттщщшшщХщХгШнрыпун 8===========э💦💦💦💦💦 this is a dick
Speaking of... Who are we really, who are the ET's, and who are the aliens? You might be surprised. Copy/paste on TH-cam and pick the sky blue thumbnail with the white text in it: "ET 101"
Searched for this exact podcast a couple weeks ago, happy to see Lex got David on the podcast, definetly think the ideas David Sinclair is talking about deserves more media attention. Looking forward to watching this :)
I'm always amazed by Lex's stance against immortality since he has so many personal interests and pursuits on top of his AI work. There are perhaps tens of thousands of professions/disciplines/fields of study/hobbies/interests that people in this world spend pretty much a lifetime trying to master and if you ask them at the end of their life if there was more work to be done they would say yes. Spend 30 years mastering leathercraft then move on to 20 years of studying ants then jump to 50 years of math/quantum physics then 30 years of Muay Thai kick boxing then 25 years mastering an instrument, etc. Hell you could take a break and kill 100 years of playing video games and jump right back into it after. There are over 300 countries in this world and you could live in each one for 10 years in order to fully experience each one and it's culture. You could spend 100s of years traveling every corner of the world. I'm not saying you wouldn't end it at some point but I think it would take thousands of years for a well developed full rounded person to get bored. There are definitely many possible incredibly engaging lifetimes for us to live if we're given the chance to do so.
That up at 7am after doing something meaningful is something I resonate with to my core as Lex mentions. For me it's composing soundtracks, it's my highlight times to do so even though, yes it puts me in temporary jet lag, in my opinion it's worth it for the release of passionate art that comes with it.
In my view, your most important or impactful interview yet. Especially since it affects everyone and at the same time is out of scope for nearly all of us.
You should definitely have Aubrey De Grey next! Arguably the most important individual in the field of biology - the OG of longevity research. On top of that he fits your podcast perfectly as he was AI researcher before he switched to gerontology. He will also very quickly change your mind on this "death is blessing in disguise" nonsense!
@@bend6799 Because exercise doesn't actually do anything lol, especially if you are already 'calorie restricted' with a low bodyweight. Jean Caulment lived to 122 without exercising. Most of the centenarians don't exercise that much.
@@bend6799 It would be wonderful if diet and exercise increased lifespan by a meaningful degree. Sadly this is not the case. If it was, we wouldn't need geniuses like Aubrey committing their entire lives pursuing strategies for engineered negligible senescence.
One of the best podcasts I have ever listened to. I have just learned of David Sinclair this week and yourself Lex today. Amazing discussion. Thank you so much! Part 2, 3, 4, 5, 6...? :-)
Well, i almost never comment on videos, but the topics and content of this podcast #189 with David Sinclair were amazing. I really enjoy this types of talks regarding human biology integrated tech, and how we can improved our health based on that concept and data. Hope to see more talks like this one in the future. I thank both for the great work !
🥰 David Sinclair's grandmother experienced the same turmoil that my mother experienced during the second world war and the Hungarian revolution. 😭. It seems like at least once per month my mother would spend the weekend reliving all of the horrors she experienced during that time when the Germans invaded and raped her and everybody was just running with nothing but the clothes on their back with bombs dropping left and right, no stores no food no place to live it's still fresh in my mind. Every time I turn the water faucet on, I am amazed at the luxuries we take for granted! 😭. 👏On the subject matter I am an avid follower of David Sinclair!🏆
Beautiful, insightful, emotional conversation. A BIG fan of David Sinclair’s life’s work. So enjoy your conversations with the 🌍 /universe’s thought leaders.
@@kenster1682 nah I'm actually almost 30 and everytime I go out people think I'm 21 cause I workout so much and have always fasted naturally for martial arts (weight cutting)
@Brett M I only fasted the day before a weight cut for 24hrs. Fasting for high performing athletes isn't great cause your muscles will self cannibalize if you don't get enough calories. I follow a lot Dr Mark Hymans advice for what I choose to eat and try to eat a lot of good fatty food with high protein content. For example one meal I eat chicken thighs, broccoli, and Japanese sweet potatoes with almonds, a banana, a Greek yogurt, blue berries and a avocado mixed with 1 cup hemp/chia/flax seeds (1:1:1 ratio for the seeds)
Absolutely love this interview... David Sinclair is an amazing man but to watch him in total awe listening to Lex is something else. There's so much information in this video it should be pinned to the top of Google search! 😎🙏
Great podcast of legends - two of the brilliant people of their generation. I am 76 and walk 5 or more miles every evening - both for cardio and for serious weight bearing on my limbs and spine. In the Army I ran, but haven't since to preserve joints. I like the balanced approach to diet - most of the time serious focus on good habits, but not denying the occasional enjoyment of an old favorite food. Thank you for the discussion.
First of all Lex I want to thank you for sharing your conversations with such amazing brilliant people. In reference to time stamp 5:30.. This made the hair on my neck stand up as tears rolled down my face. I wanted to share my thoughts.. I do believe that all human suffering is caused by wanting thing to be different then what they are, we're always wanting what we can't have. I believe this is a huge reason for our grief, unwilling to except the death as it is reality. A part of me would give my life to bring back my lost loved one "artificial or not" as another part of me questions the moral concept of this. I believe only mentally stable people could enjoy this for what it is "science". With all of this being said I'd like to add that I'm a mother that lost my 14 year old son 3 years ago. I dropped my son off at a sleep over at a friend's house and that boy decided to play with a gun... He shot my son in the chest. I do believe a huge part of moving forward with such a loss is in accepting it. As such a science would interfere with that natural process. Looking forward to many more of your talks and thank you for letting me share!
I love it Lex Fridman is a philosopher as well as a scientist. It always baffles me when I hear people say they don’t like philosophy. To me, philosophy is simply thinking clearly and trying to make sense of things. Anyway, as a philosopher, I wonder if Lex would agree that our appreciation of life, our perspective, ultimately depends on our thoughts, yet we really have no idea where they come from, and certainly no ultimate control over them. But some of us are lucky enough to stumble on wonderful conversations like this one that lead to thoughts that make our lives better. Thank you so much.
Lex, you've dropped some incredible content lately👏. I'd love to see a part 2 with your father when we hit episode #200, please upvote if you agree so he sees!!
..or we could be thankful that we live in an age where we have the privilege to be the guests of an incredibly inspiring conversation like this. When I grew up, the equivalent was a talk show host asking a celebrity what their favourite colour is.
Hi Professor Fridman, Greetings from Israel! 🌍 I've been an avid follower of your content for the past two months, and it's been an incredible journey of learning and application. Thanks for the valuable insights! I've got a couple of burning questions for you: 1. Sauna and Fasting: Wondering if hitting the sauna affects the fasting state. Does it potentially break a fast given the potential rise in blood glucose levels? 2. Intermittent Fasting and Sperm Count: There's mixed info out there. Can intermittent fasting impact sperm count? Your expertise would mean a lot! Keep up the fantastic work, and looking forward to more enlightening content.
I don't know where you find all of these fascinating people but everytime I listen to one of your vlogs I think this is the most interesting person yet till I get to listen to another vlog. Thanks so much for sharing and this is definitely the most interesting person yet!
Dr Sinclair has brought so much needed light to the process of aging and opened doors and windows in our collective consciousness that will never be closed again. But why is he trying to look like so young? One could mistake him sitting there for a sophmore highschool kid trying to mimic someone going on 19? I suppose he's doing it to show how well his work is coming along. But he could have chosen a look of, say, a 40 year old and it would still bolster his work and reputation just as much or even more. That being said, all the power to him for being able to look so young; anyone who has cracked to code of getting older like David Sinclair has done deserves his or her quirks, and all the power to him.
Great podcast but I would encourage Lex to understand how our health care system works and why it holds us back in many ways. The politics and money should not be lost in this discussion.
I find it to quite flattering that people say that Lax Fridman is the new Joe Rogan, but, that is NOT the case. Lex Fidman is a very different individual that has very deep, physical, introspective and meaningful questions for his very carefully chosen guests. Knowledge is key and I feel that his mission for humanity is key ❤❤❤
I bought Dr. Sinclair's book "Why We Age and Why We Don't Have To." It's so educative and phenomenal. Through him, I learned about NMN supplement particularly by Vitruvin Health 500mg, it's been a couple of months now as also recommended by a close friend. All I can say is that it’s cost-effective, overwhelming energy is felt, and promotes your overall health...I am looking forward to feel and see the same result in the following years…
So glad Sinclair was brave enough to talk honestly about his diet (mostly whole food - plant based). Lex pls consider this, it's based on science & over term the healthiest diet.
Very cool. List of things to check out. Brown noise. Resveratrol. NMN. MTOR amino acid. Rapamycin. 1:02:00 Sirtuin defnse in plants. InsideTracker. Cell reseting. bio wearbles. 11:48 . 7/29/21 8:38 PM
No way! I just got his book “Lifespan” and was watching some clips when he was on JRE. Been trying to find more recent videos of him. What are the odds?
Here are the timestamps. Please check out our sponsors to support this podcast.
0:00 - Introduction & sponsor mentions:
- Onnit: lexfridman.com/onnit to get up to 10% off
- Clear: clearme.com/lexpod and use code LexPod to get 2 months free
- National Instruments (NI): www.ni.com/perspectives
- SimpliSafe: simplisafe.com/lex and use code LEX to get a free security camera
- Linode: linode.com/lex to get $100 free credit
1:34 - Staying young at heart
5:30 - Bringing people back to life
11:05 - Wearables and tracking health data
20:18 - How to solve aging
30:22 - Why do we age?
35:50 - Genetic reset switch that reverses aging
38:20 - AI in biology
40:52 - Health data
48:58 - Fasting
56:29 - Diet
1:04:40 - Exercise
1:10:01 - Sleep
1:18:29 - Data
1:24:00 - Extending lifespan
1:26:42 - Immortality
1:32:28 - Denial of death
1:35:45 - Meaning of life without death
Howdy Lex! Great work on you definitely being a true solider of Love!! Good job man. Love is stronger, am hoping more folks understand this, join the consciousnesses. One of the best podcast series ever..yours. imo T h a n k Y o u
Finally! Thank you for this guest Lex! You the man!
Please invite Dr. Alireza Haghighi
What about epitalon?
"I think doctors sometimes have a bit of an ego". You bet, it shuts down their curiosity and limits their knowledge. All from cannabis, psychedelics, NDE's, the ignorance of viewing the mind and body as one thing and not separate things, diet, etc, etc. It basically makes them incompetent. And it leads to great suffering for a lot of people.
David Sinclair, a hero of mine, instead of sport players these are the guys we should support and care about, the ones that will improve our lives.
Exactly!!!
Well said
How about both???
@@WacKEDmaN ez don't make kids, overpopulation is no more.
@@WacKEDmaN you dont even know what he is doing , he has said we will die , only that the suffering and pain will be less because he will keep our body as healthy as possible , and living for 1000s of years wont be happening anytime soon , till then we would have found all the extra resources we are gonna need , also not necessary that everyone is going to choose to live for 1000s of years , most of us will get bored about a 100 and decide for euthanasia .
I am 67, I lost my brother, the last immediate family member, last year. Suddenly, I have a keen desire to live well into my 90s if not longer. For the first time in my life, I am almost afraid of dying, that, if this is it, I want to experience as much as I can for as long as I can. Thank you Lex and David for a little light in the darkness.
You are a very fortunate man to have lived to 67. I am 37 and facing a health problem Ive never faced before. Im wishing I could live for 10 more years, let alone 30 more. Have you not accepted Death, even at your age?
@@chukim8012 83% of Americans take at least one prescription medication a day. I do not take any, I just reshingled my roof alone. I work at a job I love and will continue to do so into my mid 70s. I have understand Death so in that respect I accept it, but fear the thought of premature death based on how I feel today. I have decided to live as if there is a God even though I have no evidence of that existence. That final thought prepares me for the acceptance you ask about.
I have a sale men selling watch Spair part one day I go buy some parts and take some times I told him I go have a smoke while you find my order he said do you think how old I am I said 65-70 he say I am 104 years old never drink alcohol and mom and any and smoke you see me I was amazed how never see working and physically very active so we just take care ourselves and this info at help is more an those have health problems number one is often eat less more fasting more destroy all viruses in our body even high blood pressure and stop sugar
@chukim8012 damn bro you a lil salty
@@rolandconnor575 the evidence simply seems that we exist consciously. that life is even life. let alone the ability to personally relate to this magnificent creating 'parent', one on one, heart to heart.
This was difficult and painful to watch, as my wife and I just lost our son, an only child, to sudden heart failure, on May 2, at 44 years old, leaving a 15 year old daughter. We are both 76 years old. Daniel and his daughter enjoyed time together, walking and talking about issues, gaming, cooking, etc. Still, I am glad that I watched it, and I surely would have shared the link with him, even though we both had Lex on our subscribe list. It pains me to discover that we are on the verge of wearing sensors that would have likely seen the heart failure signs far enough in advance to save him.
Daniel worked IT at the University of Michigan, Medical Services, helping to keep all of the software and hardware issues fixed. I am crying once again as I write this.
@@StrongerThanBigfoot Thank you. It's been 5 weeks, and I still cry daily about it.
@@WacKEDmaN As was explained, the user would choose who the data would be shared with.
I know it's been a while since you wrote this, but I'm so sorry for your loss. Your son sounds like an amazing person. I have an only child who is about to leave for college and I can't imagine what I would do if I lost her. I'm glad a part of your son lives on in your granddaughter and hope that brings you comfort. ❤️
@@chewyjello1 Thanks for your thoughts. It has now been over a year now since Daniel died. It is still very painful to think about.
I am so sorry for your loss. The pain you both have to bear is unimaginable, and I pray that your grandaughter, as a part of him, brings you some solace, as she matures into a woman.
I am your age and widowed, with an only son aged 51. To lose him would be to lose a part of myself.
I love hearing Dr. Sinclair speak because he always brings up something new.
Aubrey de Grey is pretty cool to listen to if you like the longevity space. He'd probably also have something new to say but he's regularlu being interviewed on smaller podcasts 1-2x a week
@@tomu4725 could you give some examples?
people will always die. This guy is delusional
@@spenser6353 you're delusional. He literally said many times immortality is basically impossible biologically and he also said he knows he's not going to live forever.
@@macpoopum7124 He said humans can possibly live 1,000 years. Thats basically immortality.
Dang lex has been really killin' the guest lineup lately
I’ve always read this comment on every video lmfao
No kidding. Each podcast makes u smarter
That phraseology, and its irony, under a podcast about life extension. 😂
@@ChrisJohn_444 and he is still: Great Scott, free
Until I heard the this episode I had a definite idea that the contemplation that we are mortals inherently drives meaning to our every moment.
I took assurance from the Greek mythology where said that gods are abusing humans because they are jealous of our mortality, as they, the Gods, have meaningless existence because they can’t die.
But now, after hearing this episode I realize that contemplating of living forever is IDENTICAL to the contemplation that we are going to die, and that it gives THE SAME meaning to every moment.
Because both give time no meaning.
Think about that: if you live forever what is the meaning of delaying to tomorrow?
Time has no meaning.
Tomorrow is identical to today.
So when time has no meaning, it’s critical to make the maximum of every moment. Not because it will not come back (mortals meaning of life), but because you can’t escape your eternal present (immortals meaning of life).
Thank you Lex and David for this existential epiphany.
Yeah but if you're fucking ALIVE then you are alive and not dead forever
Love this thought !
Big love to Grandmothers who raised their grandchildren.
Better than the creepy uncles
My grandma just called me fat and accused me of eating all her candy. 🥲
NBA nba go talk to her.
@@scottpescheret1207 lol
@Pasquale Gelardi
👍
I so agree with Lex when he talks about doctors being pretty much negligent about collecting datas, and often doing diagnostics based on %.
I'm 38 now, training a lot, and running (did half marathons and marathon). I've been on antidepressants for 10 years, I stopped this year. It's a struggle, been I'm trying to be living naturally. I've been given meds but never have they check for my testosterone levels and other potential key elements that contributes to anxiety and depression. This video inspire me To work on staying healthy and trying to be stress free.
Lex is killing it with this guest!
A pop tosis!
Cheers
Here's your 420 likes! See you in 69 days!
Back!
Lex, David, you both operate on the level where I’d like to be. This conversation embodies so much of my goals and practices. I can do it for hours, sometimes a few days, but I have a long way to go making it a constant stream. Yet, being right here doing these things, it feels like being at the forefront with you guys. It feels like support. Thank you both.
Lex is Joe Rogan without the Bro Jogan
Roe jogan PhD MBA DMT LSD is not as calm as this guy.
Frex Lidman is Lex's biological doppelganger.
Lex = Joe Rogan - Joe Diaz
Joe Rogan without the Bro Jargon **
@@UserName-ii1ce Lol Good one!
David got me interested in longevity. Aubrey de Grey showed me that we know what to do to reverse the hallmarks of aging. I hope you invite Aubrey onto the podcasts as well!
Aubrey de Grey is the legend of the longevity field - his role is drastically underappreciated by most outside the industry, because he doesn't interview as widely.
Just went to the comments to say this
He doesn't know how to do that.
@@chriscaro6832 just promoting his products. Smart guy
David's Book Lifespan is a great read...a must read imo. Looking forward to listening to this, luv both you guys!
it’s really hard to understand for the normal person. I consider myself an intelligent guy but still I was lost many times while reading it.
This type of conversation helps me to examine my choices day by day. Thank you!
Wow. Was just hoping that he would call David and boom it's in my recommendation. Thanks LEXU
Thanks for introducing me to David Sinclair. Just downloaded his book on Audible. Cheers Lex!
Fantastic guest choice! Love seeing scientists I’ve discovered on separate occasions coming together for an enjoyable and insightful conversation.
2:58 I love that Lex read this poem! I have vivid memories or reading that poem when I was 6 years old proudly to my mother...and then reading it silently to myself and feeling quite proud of how I had grown. 6 really is the BEST age. The age full of wonder, when you first start to peice the world together and search for your place in it.
Couldn't have come at a better time! I've been waiting for David to be back on JRE, but having him appear here is arguably an even better treat. Thanks Lex!
Lex has become my favorite podcaster. Thank you Lex for contributing to make the world a better place.
@@cardanowithpaui7889 You are not the real Lexi Fridman, quit playin
I truly appreciated the podcast and all your (both) philosophical points of view about life… it has been truly an honor… thanks and give us more
50:23 to 50:32 - what a sweet moment. Lex and David Sinclair are two wonderful people!
Huge thanks to Lex for having David on the podcast! It was EPIC! I interview healthy life extension enthusiasts, host Lifespan News and I'm the CEO/co-founder of Longevity Plan. I'm super focused on solving the human aging problem ASAP!
I LOVE YOU!
Whaddup Brent!
Bitcoin Cash for the win!
@@AIM-od9nr Damn straight 😉
Can you recommend others in this field
One of the most beautiful/optimistic podcasts you’ve done. Amazing to hear why no stressing out makes practical sense from a biology standpoint.
“Death smiles at us all; all we can do is smile back.”
― Marcus Aurelius
I love this
I thought that quote might have been Gandalf, but I stand corrected.
"Hahaha, sucker"
__ transhumans in the year 2200 CE
"Nah we can knock that sucker's teeth out bro." -a very wise man
"Nah we can knock that sucker's teeth out bro." -a very wise man
I think it's really worth mentioning Lex' improvement as an interviewer. I LOVED his philosophical rants while giving his guest a break in speaking and thinking. Really professional! 🙏🏼💯
Lex - I'm addicted to your podcasts! Working my way through them all and learning a lot. Thank you for helping me remain curious.
He has definitely made more interested in learning more about staying health
This conversation was a work of art. I was going to say some of the podcasts have got a bit long recently, and that this one was nice for being a more digestible size, but I think my view on this is uninteresting, the three hour talk with your dad was amazing lex, thank you and much love.
Can we just appreciate how well he explains those concepts with analogies. One of my favorite podcasts already.
Reported that scammer guy.
This is probably my favourite ever podcast. Could listen to these two all day. I can’t remember the last time I questioned my perspective so many times in a short amount of time 😂
May we live as long as we wish.
Sounds like a horrible idea. Unless we can convince people to die we will have massive overpopulation
If the vaccine dont prevent that 😂
@@kevyt3095 That is the main issue. Nowadays most people seem to be living little bit longer than they wish. But there is no easy exit, if you cannot travel to Switzerland.
@@StrongerThanBigfoot boooooriiiing
2017 eclipse in Pic?
what a role model we have in him. i am trying to encourage my grand to get into science. we need more humans like him.
Absolutely; I have some questions
I can see Lex becoming the top podcaster in the world in a few years. Great guest.
Nah he'll never be bigger than the greatest podcaster ever Bro Jogan.
If he tightens up some of his interviewing technique, maybe. He definitely gets good guests though.
@@asdfasdfasdf12 There's a reason why the world envy's America. It's the freedom they have for one.
@@matyas_laczko Yes the freedom to do and say what you please. America is the most free country in the world, much more so then Canada where I am from.
Brown noise is interesting, but definitely check out Dark Ambient music as well, lots of writers and creatives use it to great effect
New-age music is also one of my favourites, it depends on personality type imo.
The first search result for dark ambient music was a video from your channel. Well done!
Boi is that truly Cryo Chamber? Man I am a fan for almost 5 years, keep it up!
TH-cam Train rides!
@@doktormozg Awesome, all board the monorail :D I wasn't expecting anyone here to know what we do actually, what a pleasant surprise!
Wow awesome interview Lex. Seen many interviews with Dr. Sinclair but you really killed it with this and got him to open up about much more, with your great questions and extensive research.
Well thank you Lex for being a very intelligent and adequate host. It is rare because David participates in many streams and shows and there's always a host who is trying to be smart enough to match David. You did not try that - you just were yourself. This is a token of utmost professionalism.
This interview was worth every minute. Great in depth and meaningful conversation Lex.
One of the most enjoyable discussions both sides had a lot to give Dr David Sinclair is always a pleasure to listen to your facts
"How nice it is to collect data about a person, to CAPTURE that person" - Lex Fridman, Russian supervillain, 2021
🤔 Ha, ha!🤣😂
not funny-like hunting....pathetic
@@krisamagus1 well, funny is an aesthetic category, it's individual, so you do you. For me shitposting is a part of fun, it's what I do to amuse myself during a long work day. AND on my weekends. It's my hobby. I'm a bit bored AND very textually fixated, so sometimes I am guilty of leaving more than one comment on a video, this one is quite engaging after all. You could try testing your hypothesis before jumping to conclusions. I could say that you made that comment because you are 12, or because your wife doesn't give head. I could, but I won't because it conflicts with my main theory- you've got a huge brain tumor that's going to kill you in a matter of days, so you cling onto life and try to make up for all those years you wasted playing roblox by writing to a random guy and saying that you don't like his comment. It doesn't make sense, but less and less things do as the tumor grows. Black and white shapes sёём то маке seиse ьut тнеу gеt less and гёss familiar as you яeadd them. Шнат аяе тнеу? Геттерс? Геttёясс? Шнат does it all mean? You panic, because suddenly it goes back to normaг, iт sёёмs somewhaт иоямаг... Уоця degяадатион iз инэвитбл. Your рiиеаг gгаиd sёсяетs dёaтн ноямоиеssчлвщooOHмmMY GOD AM I DYINGовзыхыгаовш I DOИТ ШАИИА DIЕыоГвовоОвиыгТщылттттщщшшщХщХгШнрыпун 8===========э💦💦💦💦💦 this is a dick
@@shitjustgotreal4550 thank you
Lex is currently downloading everything on Putin in order to replicate him for an interview and private mentoring
His book is great too, and he reads for the audio book version. I highly recommend it
Two androids walk into a bar and have this comversation
Tortoise? What’s that?
"Com"versation - lol
Was it the day the Earth stood Still?
Speaking of... Who are we really, who are the ET's, and who are the aliens?
You might be surprised. Copy/paste on TH-cam and pick the sky blue thumbnail with the white text in it:
"ET 101"
I find you in the strangest of places lol
Searched for this exact podcast a couple weeks ago, happy to see Lex got David on the podcast, definetly think the ideas David Sinclair is talking about deserves more media attention. Looking forward to watching this :)
@@pinnedryanserhant6207 I dont know who Gerrad is, but my life savings are on stand-by in case you got a cool investment idea
casually says " my friend in LA just cloned his dog three times " how nice is that :D at 26.48 mn
I would of questioned that. How did they just skip over it as if it was normal
@@oliverbeck3505 cloning is a regular thing. It’s not very special anymore
@@oliverbeck3505 most of the factory farmed animals are actually clones nowadays. It's pretty crazy stuff, when you really look into it lol
@@oliverbeck3505 you would HAVE questioned that.
Is there anyone who can help me clone certain people I love?
I'm always amazed by Lex's stance against immortality since he has so many personal interests and pursuits on top of his AI work. There are perhaps tens of thousands of professions/disciplines/fields of study/hobbies/interests that people in this world spend pretty much a lifetime trying to master and if you ask them at the end of their life if there was more work to be done they would say yes. Spend 30 years mastering leathercraft then move on to 20 years of studying ants then jump to 50 years of math/quantum physics then 30 years of Muay Thai kick boxing then 25 years mastering an instrument, etc. Hell you could take a break and kill 100 years of playing video games and jump right back into it after. There are over 300 countries in this world and you could live in each one for 10 years in order to fully experience each one and it's culture. You could spend 100s of years traveling every corner of the world. I'm not saying you wouldn't end it at some point but I think it would take thousands of years for a well developed full rounded person to get bored. There are definitely many possible incredibly engaging lifetimes for us to live if we're given the chance to do so.
I think you're too optimistic, look at our world now, compare the right of longevity to wealth... same
I totally agree
Great talk, so intriguing on multiple paradigms. Might be a big ask but Lex, do you think you’ll ever be able to get Ray Kurzweil on the podcast?
That up at 7am after doing something meaningful is something I resonate with to my core as Lex mentions. For me it's composing soundtracks, it's my highlight times to do so even though, yes it puts me in temporary jet lag, in my opinion it's worth it for the release of passionate art that comes with it.
In my view, your most important or impactful interview yet. Especially since it affects everyone and at the same time is out of scope for nearly all of us.
You should definitely have Aubrey De Grey next!
Arguably the most important individual in the field of biology - the OG of longevity research.
On top of that he fits your podcast perfectly as he was AI researcher before he switched to gerontology.
He will also very quickly change your mind on this "death is blessing in disguise" nonsense!
How would anyone know that it wasn’t?
Aubrey De Grey gets all of his Reservatrol through natural means … by consuming gallons of wine a week.
Aubrey doesn’t exercise. All his claims become dubious after i learned that
@@bend6799 Because exercise doesn't actually do anything lol, especially if you are already 'calorie restricted' with a low bodyweight. Jean Caulment lived to 122 without exercising. Most of the centenarians don't exercise that much.
@@bend6799 It would be wonderful if diet and exercise increased lifespan by a meaningful degree.
Sadly this is not the case.
If it was, we wouldn't need geniuses like Aubrey committing their entire lives pursuing strategies for engineered negligible senescence.
One of the best podcasts I have ever listened to. I have just learned of David Sinclair this week and yourself Lex today. Amazing discussion. Thank you so much! Part 2, 3, 4, 5, 6...? :-)
I have talked with David
Well, i almost never comment on videos, but the topics and content of this podcast #189 with David Sinclair were amazing. I really enjoy this types of talks regarding human biology integrated tech, and how we can improved our health based on that concept and data.
Hope to see more talks like this one in the future.
I thank both for the great work !
🥰 David Sinclair's grandmother experienced the same turmoil that my mother experienced during the second world war and the Hungarian revolution. 😭. It seems like at least once per month my mother would spend the weekend reliving all of the horrors she experienced during that time when the Germans invaded and raped her and everybody was just running with nothing but the clothes on their back with bombs dropping left and right, no stores no food no place to live it's still fresh in my mind. Every time I turn the water faucet on, I am amazed at the luxuries we take for granted! 😭. 👏On the subject matter I am an avid follower of David Sinclair!🏆
Lex, the work you do is wonderful. Like David, you are making the world a better place. Thank you
Beautiful, insightful, emotional conversation. A BIG fan of David Sinclair’s life’s work. So enjoy your conversations with the 🌍 /universe’s thought leaders.
How do I get the latest Bio Sensor?
What are the supplements we should take? What are the steps? Too many questions..I appreciate this so much.
I swear this dude gets younger looking every podcast lol
I think you are just doing carnivore and aging faster😂😂
@@kenster1682 nah I'm actually almost 30 and everytime I go out people think I'm 21 cause I workout so much and have always fasted naturally for martial arts (weight cutting)
@Brett M I only fasted the day before a weight cut for 24hrs. Fasting for high performing athletes isn't great cause your muscles will self cannibalize if you don't get enough calories. I follow a lot Dr Mark Hymans advice for what I choose to eat and try to eat a lot of good fatty food with high protein content. For example one meal I eat chicken thighs, broccoli, and Japanese sweet potatoes with almonds, a banana, a Greek yogurt, blue berries and a avocado mixed with 1 cup hemp/chia/flax seeds (1:1:1 ratio for the seeds)
@Brett M weight cutting is mostly just water loading and cutting sodium the week of the weight cut
I wonder if it's the intermittent fasting or if the metformin and/or resveratrol really is keeping him younger.
Lex is at the top of his game. Excellent interview style.
LEX ! I was waiting for this one... Thanks a lot for all the great work you put into these podcasts. Greatings from Belgium.
Absolutely love this interview... David Sinclair is an amazing man but to watch him in total awe listening to Lex is something else. There's so much information in this video it should be pinned to the top of Google search! 😎🙏
It's always a fascinating listen with Mr.Sinclair! Excellent episode, as per usual!
Great podcast of legends - two of the brilliant people of their generation.
I am 76 and walk 5 or more miles every evening - both for cardio and for serious weight bearing on my limbs and spine. In the Army I ran, but haven't since to preserve joints. I like the balanced approach to diet - most of the time serious focus on good habits, but not denying the occasional enjoyment of an old favorite food. Thank you for the discussion.
First of all Lex I want to thank you for sharing your conversations with such amazing brilliant people. In reference to time stamp 5:30.. This made the hair on my neck stand up as tears rolled down my face. I wanted to share my thoughts.. I do believe that all human suffering is caused by wanting thing to be different then what they are, we're always wanting what we can't have. I believe this is a huge reason for our grief, unwilling to except the death as it is reality. A part of me would give my life to bring back my lost loved one "artificial or not" as another part of me questions the moral concept of this. I believe only mentally stable people could enjoy this for what it is "science". With all of this being said I'd like to add that I'm a mother that lost my 14 year old son 3 years ago. I dropped my son off at a sleep over at a friend's house and that boy decided to play with a gun... He shot my son in the chest. I do believe a huge part of moving forward with such a loss is in accepting it. As such a science would interfere with that natural process. Looking forward to many more of your talks and thank you for letting me share!
My God, that is heartbreakingly awful. I'm so sorry for the loss and pain you've endured. Sending you another mother's hug and caring.
This is a great conversation. Totally agree with David about enjoying life whenever you are immortalized or not.
Great conversation! Always good to hear David's insights and knowledge as well as Lex's philosophy! Thanks!!!
I love it Lex Fridman is a philosopher as well as a scientist. It always baffles me when I hear people say they don’t like philosophy. To me, philosophy is simply thinking clearly and trying to make sense of things. Anyway, as a philosopher, I wonder if Lex would agree that our appreciation of life, our perspective, ultimately depends on our thoughts, yet we really have no idea where they come from, and certainly no ultimate control over them. But some of us are lucky enough to stumble on wonderful conversations like this one that lead to thoughts that make our lives better. Thank you so much.
Lex, you've dropped some incredible content lately👏. I'd love to see a part 2 with your father when we hit episode #200, please upvote if you agree so he sees!!
I'll probably never see any of you in person, but I love you all, thanks for making this temporary immortality great
YES to stressed plants🌱💪🍇! LOVE this topic (and longevity in general). GREAT conversation LEX and David🙏💜🤗
..or we could be thankful that we live in an age where we have the privilege to be the guests of an incredibly inspiring conversation like this. When I grew up, the equivalent was a talk show host asking a celebrity what their favourite colour is.
Another inspiring interview. Interesting to hear what is going on in the labs and what we hopefully soon can use for a reasonable amount.
Hi Professor Fridman,
Greetings from Israel! 🌍 I've been an avid follower of your content for the past two months, and it's been an incredible journey of learning and application. Thanks for the valuable insights!
I've got a couple of burning questions for you:
1. Sauna and Fasting: Wondering if hitting the sauna affects the fasting state. Does it potentially break a fast given the potential rise in blood glucose levels?
2. Intermittent Fasting and Sperm Count: There's mixed info out there. Can intermittent fasting impact sperm count?
Your expertise would mean a lot! Keep up the fantastic work, and looking forward to more enlightening content.
What a beautiful interview
Thank you gentlemen
I don't know where you find all of these fascinating people but everytime I listen to one of your vlogs I think this is the most interesting person yet till I get to listen to another vlog. Thanks so much for sharing and this is definitely the most interesting person yet!
@Lex Frídman
Hey was this your reply?
Vitalik and then Sinclair wow
@@michaelfried3123 Wow, I wasn’t aware. Also haven’t seen the video yet, maybe I’ll check it out and see what just happened 😂
@@michaelfried3123 not true man!
@@michaelfried3123 what lie? you mean the hard fork stuff? that was bothersome.
@@michaelfried3123 where is it?
We are going to live as long as we want guys!
This was time well spent, great interview.
Great interview Lex! I'm really excited to be part of this growing field and the ability to enhance healthspan.
This needs to be way higher;)
@@ilyaantonyuk9723 yeah
love ur vids.
Dr Sinclair has brought so much needed light to the process of aging and opened doors and windows in our collective consciousness that will never be closed again. But why is he trying to look like so young? One could mistake him sitting there for a sophmore highschool kid trying to mimic someone going on 19? I suppose he's doing it to show how well his work is coming along. But he could have chosen a look of, say, a 40 year old and it would still bolster his work and reputation just as much or even more. That being said, all the power to him for being able to look so young; anyone who has cracked to code of getting older like David Sinclair has done deserves his or her quirks, and all the power to him.
Would love to see Dr. Valter Longo on the podcast. A professional guitar player turned longevity and diet expert. Would be awesome to see 👌
Great podcast but I would encourage Lex to understand how our health care system works and why it holds us back in many ways. The politics and money should not be lost in this discussion.
Are you implying that the US should have a european system health system?
I clicked on this the save it to my history to comeback to it… It’s 04:00 AM and I’m an hour in
I cant believe this is free content. What a time to be alive
I've grown to accept lexs monotone ass voice
He's used to talking with artificial intelligence. It rubs off.
I still find it so off-putting...
Monotone voice is the best voice for podcast and documentaries. Just an opinion.
@@mutant1643 maybe for a documentary but definitely not for a podcasts....but whatever floats your boat my dude
If you listen closely sometimes he sounds like a surfer bro.
Lex is getting good at these interviews. It's almost as if he's learned his best to approximate human emotions!
Hapoy birthday Dr. Sinclair. Happy to be watching this today.
I feel the same way Lex. Stay young. You and your guests crystalize my thoughts. Keep on doing what you do.
Thanks for watching
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+ 𝟣 𝟥 𝟣 𝟧 𝟤 𝟪 𝟢 𝟧 𝟢 𝟪 𝟦
ive been waiting for this one
💯
When you like the video immediately after clicking it
Now waiting for Aubrey de Grey
Me too
I find it to quite flattering that people say that Lax Fridman is the new Joe Rogan, but, that is NOT the case.
Lex Fidman is a very different individual that has very deep, physical, introspective and meaningful questions for his very carefully chosen guests. Knowledge is key and I feel that his mission for humanity is key ❤❤❤
You spelled Lex Friman wrong... a little suspicious...
amazing episode! I really liked sinclair on rogan aswell, very well spoken and super informative 👌
I bought Dr. Sinclair's book "Why We Age and Why We Don't Have To." It's so educative and phenomenal. Through him, I learned about NMN supplement particularly by Vitruvin Health 500mg, it's been a couple of months now as also recommended by a close friend. All I can say is that it’s cost-effective, overwhelming energy is felt, and promotes your overall health...I am looking forward to feel and see the same result in the following years…
Damn bro, glad I found you from chain-link subreddit. You're inviting the most bomb guests 💯🤩
Hey, I remember that recommendation!
Thank you for putting timestamps on your videos 🙏
long live these men
That's the idea.
So glad Sinclair was brave enough to talk honestly about his diet (mostly whole food - plant based). Lex pls consider this, it's based on science & over term the healthiest diet.
who cares about diet & exercise? all Lex needs is 4 hrs of sleep per night...
👏YES!!! 48 minutes in and I am convinced that Lex is a genius! 🏆
Listening to Lex has made me smarter
He is genius and is very humble at the same time. Perfect combination.
Brown noise just turned all the "junk" in my head to something more meaningful! Thanks Lex!!!!!
Awesome episode, as always. Dr. Sinclair is one of the coolest scientists out there. I'm waiting eagerly to see the fruits of his labour.
Very cool. List of things to check out. Brown noise. Resveratrol. NMN. MTOR amino acid. Rapamycin. 1:02:00 Sirtuin defnse in plants. InsideTracker. Cell reseting. bio wearbles. 11:48 . 7/29/21 8:38 PM
Absolutely amazing
48:30 When Lex cracks a joke its so unexpected, I think I woke my neighbour laughing.
Great talk, I didn't want this one to end.
No way! I just got his book “Lifespan” and was watching some clips when he was on JRE. Been trying to find more recent videos of him. What are the odds?