The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com ) and here on TH-cam: th-cam.com/users/davidsinclairpodcast. Thank you for your interest in science!
My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you.
When someone tells a story like this, a lot of people will say or think, "That's just anecdotal." But when there are so many anecdotes pointing one direction... where there's smoke, there's fire. Love hearing stories like your Dad's, and it's inspiring for those of us half his age to continue to prioritize health and self improvement, and maybe even help others on that journey.
Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.
I think he's spreading himself too thin, though. He's been firing off these podcasts so rapidly, and I just want to say, dude, slooooow down. You're going to burn through all your best potential guests quickly, and it's too much for a lot of us to absorb anyway.
In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!
@@cindysmallwood2695 he obviously wants to make questions as clear as possible and, in my opinion, very much succeeds. You mam, I assume, just jealous.
I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!
Hi Vicki, I couldn't agree with you more. I once had an older bodybuilder (72 yrs old) tell me to stay away from processed food, and you will be ok, Rudy. Thanks for your reply. Cheers! Rudy
One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.
Thank you for sharing your incredible story of resilience with us. I am so sorry for the trauma that you experienced and very grateful that you are housed and recovering now. My best wishes and prayers for you.
@@EmiKimura88 The homeless survive with the help of kind strangers, but the best way to help in the long-run is supporting the push for democratic socialism, for much stronger social safety nets, and social investment in mental health, addiction support and housing, instead of policing and criminalization of the homeless. The phenomenon of homelessness is absolutely connected to society at large and politics.
2 humble geniuses genuinely appreciating each other’s genius. No competition. No agenda. (Except to share) wow! What a gift indeed. Everybody loves this
@@szymonbaranowski8184 yeah I'm not so sure about NMN cause there's so much contradiction involved, some say no it doesn't get into the mitochondria of the cell so can't increase lifespan as it does in mice
What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share .
I do the same at 70, convinced I can beat the chronic kidney disease I have had since 2005, for which modern medicine offers nothing but ineffective drugs with powerful negative side effects. Never once has the concept of fasting, sirtuin pathway activation, mTOR inhibition, autophagy, NMN supplementation to increase NAD+, or stem cell regeneration crossed any of my MD's lips - criminal.
Fasting is easy if you place yourself in a location where there is no food and you don't leave that location. Drink some water and get over it. It's not like being cold and getting colder. When you are hungry, you don't get more hungry. You're just hungry, and if you eat, you'll probably be hungry again in a few hours. So cowboy up.
I am 37 and I’ve never intended to fast but my routine sounds like exactly what he mentioned. I eat once per day, never crave sugar or carbs. Once our body gets used to with the routine, my mind listens to my body instead of the other way around. It’s so important that we understand our body & listen to it because our body is science itself.
Most of the more severe illnesses happen to people because an upsetting event occurs in their lives taking them by surprise, unexpectedly, impacting first in the brain, then in the corresponding organ which that part of the brain controls. The end of WWI had absolutely everything to do with the Flu and lung TB outbreak that occurred killing millions. In nature, the biological conflict linked with a territorial fear (just what it means-a fear in your territory, your home, your community, etc.) is a widening of the bronchia (tissue loss). Your body attempts to widen your bronchia in order to allow more air into your lungs to give you more strength and energy to fight to keep your territory safe. Stay with me.......The biological conflict linked with a death fright impacts the lungs. The lungs attempt to grow larger in order to allow more air in because breath equals life, as we all know. No breath equals death. While you are in the fear or death fright conflict, you notice no symptoms of “disease”, except you have cold hands, cold feet, you can’t sleep, you awaken at 3 AM every night, you have little appetite. During the war, millions of people were in fear of the bombing of their homes and cities where the war was most active. Fearing for their lives, their loved ones in the war, their ability to survive. The food in the stores was sparse due to shortages. This lasted for 4 long years! The longer the conflict, the worse the healing phase. Within 2 weeks of the German Chancellor announcing the end of WWI, these millions of people ALL went into the healing phase all at the same time. It is during the healing phase that you experience symptoms of illness! What is the healing phase of the bronchia widening? Severe bronchitis, pneumonia. The body attempts to refill this lost tissue and you experience inflammation, fever, coughing, body aches, fatigue, etc. What is the healing phase of the extra lung tissue that grew? Decomposing of the tissue by TB bacteria and fungi. The symptoms of this healing phase are: severe coughing up of blood and tissue, fever, inflammation, severe mucous, body aches, fatigue. During this decomposing of the extra tissue (tumor), the body expels a lot of protein, and without replenishment, severe protein loss can result in death. Antibiotics did not exist yet. If TB bacteria does not exist in a person or they have been vaccinated against TB (big mistake), then the tumor will simply encapsulate and become dormant and not harm you. Who died during the Spanish Flu? Mainly the poor who could not afford to buy meat and proper nourishment, and the people who were directly impacted by the bombings and destruction of their homes. Millions of people suffered fear and death frights during the fighting of WWI, and millions of people all went into healing at the end of it. Not everyone was affected because not everyone suffered the same way. It’s not a “flu”, it’s not something you “catch”. It’s biological, meaningful, and unavoidable. One hundred years later, a Fear Campaign begins, using the media to spread it......
Thanking you very much for your brilliant work on genetic influences attaining fountain back to youth so to speak .people close to me are astonished at the bullet proof genetics I was blessed with I just turned,60 don't look day over 40 literally lived the life of a rockstar rarely ate and when I wasn't obliterated it was all about adrenaline surf snow skydiving racing motorcycles cars . never seen a depressed person dropping into 20ft wave wondering if adrenaline has benefits slowing deterioration of are meat suites
I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.
After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life. Thank you so much for introducing us to his work!
@@xxcorrosive Not a tough read, in fact there are illustrations and Dr. Sinclair isn't pompous or evangelical, in fact he's pretty humorous at times. I'm still reading it, because I skip around a lot of books at once, and even within the book.
Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.
It sure is .I've been through it, and it's horrible. I didn't take any hormones, etc, but I have autoimmune disorder, etc. I have reversed so much on my own. Your skin dries out, our moods change,gain weight ,allergies,incontinence decresed libido and our bone density changed.Sleep changes, burning mouth, dizziness, breast tenderness, osteoarthritis, my nails started breaking off, IBS ,changes in taste, food cravings, bloating, itchiness, I had severe joint pain ,electric shock feelings ,pins and needles, mood swings, hot flashes, heart racing/ irregular heartbeat, and sweating in the middle of the night to shivering. Irritatable and feeling really flushed.Memory, anxiety, panic attacks , and brain fog are similar to my fibromyalgia, CFS. Men don't realize the hell we go through, but they aren't mind readers either, so I appreciate your comment. It's when they read about what the women in their lives are going through, they start to think wow it's a lot.,Some women are so busy they don't even realize they are suffering, and some don't say a word ,leaving their male family's wondering what's happened. If they could experience a day in our shoes ,I think they would be shocked. We go through a lot. I've recently started taking NMN. I have energy and I thought I was losing my hearing because I kept saying can you turn the radio down etc but my hearing was not working properly before. Now I realize I can hear so much better, I wore glasses being near sighted I couldn't see far away,and as we age bi focals come in and we turn into our local librarian . So i do the test and it comes back saying your eyesight is way better and you only need glasses to drive to see long distances. So my energy from NMN,TMG,my eyesight is better,my hearing is sensitive, now i just have to work on these D knees. 😂
Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier. Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you.
It’s always nice to come across someone else that this podcast is helping. Thanks for sharing, and good luck going forward. I feel pretty certain stories like yours are what they hoped to create when they kicked the podcast off. 👍🏻
I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️
This is gold… I am 48 and started taking AG1 and NMN and I got pregnant…. Nothing else had changed except those two things! … I did lose the baby at 3 months but I understand the body will do what the body wants… the key is consistency!
He looks every bit of 52.. However, maybe if he wasn't taking all of his anti-aging supplements and taking care of himself, he would look older than that
The internet creates a spawn of information, but information isn't intelligence. Thank you for continually putting out a sense of logical thought and allowing the public to sit in on conversational engagements between intellectuals like this. Excellent work.
This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done!
Comment on the first minute (before watching it all): For over 3.500 years Chinese culture knows about longevity and slowing down the aging proces by prevention, medicine and health-care. Think (but not alone) QiGong, Tai Chi, Tai Yin (Chinese Yoga), Kung Fu, acupuncture, Tui Na (massage and manual therapy), cupping, plants and herbs, and so on. Based on YinYang and or 5 Elements, An integral and holistic approach for health including reversing / slowing down aging. Just start with what resonates with you, get some intel and go from there. You won't regret it. Having said that, iam gonna watch the vid now ;-) And many thanks for Andrew Huberman for his -free- series on health. I've learned a lot 🙏
I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done.
I’ve drank heavily. HEAVILY for at least 20 years. Not because I enjoy it, but because my anxiety problem is very temporarily masked by it (but also exacerbated by it). I’m 38 in a couple of weeks and I’m terrified that it’s going to hit me very soon and I’m gonna be very ill or look like a haggard old prune in the near future. 2023 is my goal to do at least 4 weeks abstinence from alcohol because of another of Dr Huberman’s videos on dopamine which perfectly described my affliction with alcohol use.
Dear Andrew, I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!
I love how you encourage other scientists to start their podcasts! But also episodes with guests, no matter how interesting they are, just make me appreciate episodes fully conducted by you. I love the logic in the sentences.. it’s so pleasurable to follow🤤
Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies.
This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work
Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us!
Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done!
Keep in mind that he has access to high level professional tests any time he wants to optimize how he interacts the world. This is not available to most.
I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing.
Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving!
What an amazing podcast! I've watched dozens of interviews with David Sinclair. Dr. Huberman asked different and intriguing questions that no one else has asked before. Two brilliant and forward thinking scientists together, sharing provocative ideas and insights. This podcast gets my vote for "best of 2021". Thank you!!!!i
Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!!
I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic!
We Are being lied for many years.He actually pointed it out that living longer is connected to eating less which was ignored by the medic world no wonder why
My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans.
This is still better than any movie released since this episode. Such a high repeat value I can watch it for fun sadly not with popcorns, two of my most fav scientists today
Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen.
It's insane to think about how much more medical/life changing information has been discovered/is known around the world but is still not a common part of everyones daily lives... What a wonderful world this could be...
@@chadspro You’re probably talking about resource allocation, over population, increased disease, etc.. and you’re probably right. But I’m a bit of an optimist and believe that there is a Pugh resources to handle quite a bit more people, however, people would need to learn how to be more resourceful, live a life of less waste, learn how to provide for themselves, etc.. Essentially, I believe it’s possible that we could live longer and in a larger population while staying in harmony with the nature.
I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview.
The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things.
My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️
Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol
The advice is essentially to have a long term plan (future authoring can help with this - I got it, it's pretty good), make a schedule (Google calendar is fine to use), try following it alittle more than the day before, start small you will improve. Paraphrasing, he said more but that's all I remember and it's pretty useful imo.
I can't even dare to explain how valuable this podcast was. Thank you very much! I would also LOVE to listen to your philosophical conservation. Please consider that. The youth/future needs real influencers like you guys!
This is going to sound backwards but seeing this makes me grateful for that anorexia diagnosis in high school. I’m saying this on the other end of it, as a middle-ish aged woman, and forever grateful that I survived and recovered, but glad to know that there was likely a silver lining to that hell.
@@FriendMariaAdrianna longevity. I think I look my age but I am pretty fit and healthy overall in comparison to what I hear from a lot of my peers. I also have 3 kids and a full time job at this point so I think the wear and tear is equivalent.
Best ever. I nerd out trying to figure out my ADHD brain and my genetics from my 23 and me data through other companies. I’m a 51 yr old female and people think I’m 35. I’m so signing up on Dr Sinclair’s website!! Thank you for this amazing podcast!!!
@@isabellalora6533 maybe because I blocked my face from the sun since age 23. I saw all my sun loving friends aging back then. My grandpa always pushed Vit C too. And maybe genetics played a huge part. I have no forehead wrinkles nor 11 lines between eyes. Only thing that shows a little age is under my eyes here and there on bad days.
same here but i wish we get more clarity on resveratrol because according to Dr brad and multiple others doctors suggesting not to take resveratrol, hopefully we will get more clarity from huberman or sinclair soon
@@Chrissssk if you don't want to take resveratrol, just take olive oil. NMN + olive oil works good for me. I'm 37, I weigh 93kg (admittedly I exercise hard 5 times a week) and my resting heart rate is 47.
The whole podcast is excellent! Weird/interesting about people ingesting Methylene blue. True story: About 9 years ago, our son was using his microscope set and had powdered methylene blue for his slides. Unfortunately, our rat terrier got into it, and knocked over and ate some of the methylene blue and caused it to get airborne. For days we found deep blue blooms of it all over our white tile floor. We took her to the vet, and found out that methylene blue is given to dogs when they have Tylenol/acetaminophen poisoning and have developed Methemoglobinemia. Our rat terrier was fine (and is still fine), though she had dyed her insides and created a lot of work for this gal. Another fantastic podcast! Learned so much!
Thank you very much for this. What a great podcast. Learned so much. Grateful for your work. I would be very interested in an episode about funghi (lions mane, chaga, reishi, cordyceps etc.) And what they can do in relation to longevity. Thanks a lot, very great content.
What a brilliant podcast! In absolute awe - extremely grateful to you both for your service to humanity and your commitment to educating the public! loved this.
thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons.
When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.
it's funny my grandmother never had a highschool diploma let alone a PHD in Neuroscience or biology or anything else, She ate in moderation, enjoyed good food , enjoyed bad food , she danced was active , loved family and friends dearly , and had a great outlook on life! Also she never drank alcohol much , and never smoked , lived to past 94 years old , this is the template for a healthy long robust life,
I have been following David Sinclair for few months now and he has been interviewed by very smart guys here on youtube, but this was his best interview ever. Great job Andrew, You asked him some amazing questions, this is very educational, I am going to follow you closely from now on.
When Dr. Sinclair said he was proud of your accomplishments, you breezed past it and changed the subject. My best suggestion, is next time you receive a compliment, take a deep breath (I know you're big on that) take it all in. Just absorb it, and take a moment to enjoy it, knowing how much you've earned these acknowledgements. Just my thoughts. Thank you so much for what you bring to the table, I appreciate you so much!
Sorry, WHAT? I had to rewind that... did he just say he's 52?! This man does not look a day over 30! Since turning 40 six month ago, I've become much more mindful of my overall health, I've increased excercise, put more thought into my diet, my sleep habits and cut out alcohol (having reduced from drinking 2 nights a week, to 1 night, to once a fortnight, to once a month, to once a quarter). I'm naturally slim and have never eaten more than 2 meals a day, usually just 1. Dr Hubermans podcasts have had a real positive impact on my life, and this one didn't disappoint. Thank you gentlemen 🤍
This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions
I took resveratrol because of his research in the 2000s in my early 30s. I had a critically bad response and all of my tendons became really weak and I had massive onset of what felt like arthritis throughout my body. I was on the Imminst/Longecity forums back then and there was a subset of people on resveratrol who had very bad tendon responses. Sometimes they would just get up out of their chair and rip their Achilles tendons. Never touched resveratrol since then and it took years to recover, and I don't think I ever fully did.
I hope you see this, you could have had a herx reaction because resveratrol is used to treat Lyme disease. 14% of the world population has it you should test for it. Lyme in particular causes the “feel worse” and the symptoms you described are textbook herx symptoms
Sinclair's reservatrol has come under heavy criticism by the scientists and the positive effects interpreted was considered false. This came out AFTER all the hype and after he sold his reservatrol company for $720M. He bevere apologized or recanted his suggestion
Something no one talks about is indoor air quality. The last 100 years we have built more and more air tight homes. High C02, VOC’s, and particulates are causing short and long term health conditions. I was one of them. We had to add ventilation to our home because I couldn’t sleep due to discomfort. Once we did that, I can now sleep well and I feel much better overall! It plays a big part in how we feel. But, you can’t see it so no one cares. But, we breathe 40lbs of air per day.
I’m a residential contractor. New building codes require supplemental air exchange for new construction… hopefully this will help with the poisons in the residential air 👍
I’d really love to know more about fasting and women’s health, particularly during peri/menopause. I’ve done IF once, for 6 weeks, and my hormones became imbalanced, I gained weight, and lost my hunger cues and overall appetite. My overall calories were appropriate and I was getting optimal nutrition. I suspect there was something in the particular IF pattern I was using that was ill-suited to my physiology. But I’d like the health-benefits of it. Is there any literature on IF for women in or nearing menopause?
Thank you for this. I came here to write something similar, including peri/menopause but also extended to various aspects of women's health. What cautions or considerations if trying to get pregnant, or pregnant, or breastfeeding, or with tendencies towards eating disorders (more prevalent in women), etc.? There is overlap with men, but SO many differences. Though I appreciate the portion in the podcast on fertility. Really interesting.
@@audrey3042 Thank you. Looks good, though I don't see anything in her material about pregnancy, breastfeeding, teenagers, eating disorders, etc. I will do some more poking around.
I'm not a woman..nonetheless a human and have experienced similar thing - and HUGE problems with cortisol and arenalin with IF. When I introduced breakfast I actually started loosing weight and experienced less stress and anxiety and better mood.
Oh, my goodness how amazing and informative is this conversation -For me it was a class! I took notes and study every bit of it, it took me two days to actually finish watching the whole conversation. Thank you both for helping us ask the right questions, and be aware of all the goodness that can helps us do better in our health.
I am only in 18mins and This conversation is so interesting between two great educated minds. I am hooked, love it already Oh and NOT drinking alcohol is definitely not boring AT all. Love it
Dr. Huberman, can you tell us which brand of NMN supplements your sister takes and what dosage she’s found is optimal? In future episodes when you suggest protocols, it would be helpful if you could share which of them (and to what extent) your sister and/or other women in your life also practice. (With their permission of course)
@@andreaodney6914 no answer but there seems to be trouble in at least the NMN supplementation research. @ Physionic just posted a video on the subject. Also the Lifespan podcast with Sinclair doesn’t appear on the scicomm media website anymore so not sure (but kinda sure) what happened there. I could be looking in wrong spot.
@@_negentropy_ Ok, I'm not sure what the scicomm media website is, or what the implication is for it not being there, but maybe I'll check out the physionic video, thanks!
"We'll all be like Dead Pool." The same day I listened to this, my mom commented on my 92 year old step dad's uncanny ability to heal quickly. She was a nurse and nursing instructor and has noticed this ability over their 40 years together.
OMG. JE SUIS TROP HEUREUSE QUE CETTE INTERVIEW AIT LIEU 😭 MERCI Perfect end of the year, best wishes for this podcast, its crew, and all of the viewers that are interested in science. 🥳
This podcast made an incredible positive impact on my life.! After watching this I started taking NR 600mg a day and experienced an incredible energy boost. I’m 48, juggling a career and two kids. I never had the energy to workout after work and now I have so much energy I WANT to workout everyday! I’m actually running! Something I never did before because I struggled to breathe. The only thing I did before was yoga sporadically and some hiking. I feel younger, healthier and not so concerned about turning 50. My skin has improved too. I feel like I’m changing from the inside out. I’ve been eating OMAD 4 days a week for a couple of years. Since these guys take AGI also started taking it after introducing NR. I recently added NMN and I can feel the difference when I added that too! So much energy it’s life changing! Also my chronic neck pain went away and I sleep better too. Oh and I started my 87y/o mom in NR and she keeps asking me for more since she’s been feeling more energetic on it as well. Thank you so much for sharing this scientific information, it had been life changing implementing what I’ve learned from this.
I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated.
Great content. Unfortunately, I have to skip ads when watching but whenever I have to think about the information I let the ads run as I can't have the ads interrupt my thoughts. Also, if there was summary notes about the key topics (supplements, time of use etc) the podcast/channel will be god-tier level. Keep up the good work Dr Huberman.
I've had a mental note for weeks to request Dr Sinclair as a guest...and you beat me to it. This is amazing information - thank you! Also, an observation (which, no doubt, many people make): I am reminded how very youthful Dr S looks. Seriously - does he not look like he is in his early 30's or even younger???
@@AlexanderMoen if people think he "looks" his age, I just don't see it. I, too, am in my 50s. What strikes me is that he has little to no gray hair, smooth unlined skin and a boyish body. Unless filming techniques are hiding something, I think if I walked by him on a sidewalk, I would guess-ti-mate him to be in his 30's.
The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com ) and here on TH-cam: th-cam.com/users/davidsinclairpodcast. Thank you for your interest in science!
What a beneficial opportunity to learn and grow more. Thank you for this
P.S.= Oh and happy almost New Year
Type 1 diabetic here. Lots of Type 2 talk regarding longevity. I have no insulin in me, does that help me? How screwed am I
@@BS-lc5cd my 12 year old daughter has type 1 diabetes. 8m so grateful for your question.
Great interview Andrew! Thank you so much for bringing David on and asking the questions that you did, you've out done yourself yet again.
My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you.
Wow! Your Dad sounds awesome! Good for him!
When someone tells a story like this, a lot of people will say or think, "That's just anecdotal." But when there are so many anecdotes pointing one direction... where there's smoke, there's fire. Love hearing stories like your Dad's, and it's inspiring for those of us half his age to continue to prioritize health and self improvement, and maybe even help others on that journey.
Dr Sinclair is an absolute genius and I am great full for his amazing work to change mankind mindset regarding aging
low caloric intake = looking like a emaciated soyboy with no muscles.
Legend
Welcome to the Future everyone, where golden information like this is free and available instantly.
We are the Future
.
.
TH-cam is more than 15 yrs old.
The future is getting this info directly chipped into your brain and available immediately
@Brett M I think you missed the point
@@JC_inc Jesus Christ zero common sense
Two scientists that I follow all the time, now on one podcast. This is a Christmas gift.
Yeah! By Far the best Christmas Gift!
So true!! Same feeling here!
same here!
Yep top Christmas inspiration from my two fav scientists. Very proud of our Aussie Sinclair🙏👌
Bhai very nicely put!
Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.
I so AGREE!
i am a man, but i totally agree, lol
Definitely! 😅
I think he's spreading himself too thin, though. He's been firing off these podcasts so rapidly, and I just want to say, dude, slooooow down. You're going to burn through all your best potential guests quickly, and it's too much for a lot of us to absorb anyway.
😂❤
Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew
Live-longer fads (and people making money off of them) have existed for decades.
Just think of all the people that will live an extra week or two because of this video.
resveratrol and nmn are not free though :>
People are gullible nowadays, a sad fact...
Unfortunately it only works if you are not worried or thinking about living longer.
In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!
Except that Huberman really likes to hear himself talk. Questions could be summed up in half the time.
@@cindysmallwood2695 he obviously wants to make questions as clear as possible and, in my opinion, very much succeeds. You mam, I assume, just jealous.
@@cindysmallwood2695 He knows he's a specimen
@@alsin1597 you offended on his behalf. He's a lecturer. It's undeniable he talks a lot
@@thomasbeaumont8884 what... I am actually stand for him
I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!
Where do you practice?
@@healingjourneys4241 Illinois
@@vickihughes926 wish I was closer because you sound like a perfect physician for me.
Hi Vicki, I couldn't agree with you more. I once had an older bodybuilder (72 yrs old) tell me to stay away from processed food, and you will be ok, Rudy. Thanks for your reply. Cheers! Rudy
Have fun making no cash. All the money is in the meds.
Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally.
One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.
Thank you for sharing your incredible story of resilience with us. I am so sorry for the trauma that you experienced and very grateful that you are housed and recovering now. My best wishes and prayers for you.
@@saraayazbutt Thank you for your kind wishes
thank you for sharing your story .
I've just had an urgent desire to help homeless people
@@EmiKimura88 The homeless survive with the help of kind strangers, but the best way to help in the long-run is supporting the push for democratic socialism, for much stronger social safety nets, and social investment in mental health, addiction support and housing, instead of policing and criminalization of the homeless. The phenomenon of homelessness is absolutely connected to society at large and politics.
2 humble geniuses genuinely appreciating each other’s genius. No competition. No agenda. (Except to share) wow! What a gift indeed. Everybody loves this
Sinclair promotes the greatest global experiment on human beings... so not so much agendaless... not mentioning nr of pharma businesses involved...
@@szymonbaranowski8184 yeah I'm not so sure about NMN cause there's so much contradiction involved, some say no it doesn't get into the mitochondria of the cell so can't increase lifespan as it does in mice
What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share .
I do the same at 70, convinced I can beat the chronic kidney disease I have had since 2005, for which modern medicine offers nothing but ineffective drugs with powerful negative side effects. Never once has the concept of fasting, sirtuin pathway activation, mTOR inhibition, autophagy, NMN supplementation to increase NAD+, or stem cell regeneration crossed any of my MD's lips - criminal.
Fasting is easy if you place yourself in a location where there is no food and you don't leave that location. Drink some water and get over it. It's not like being cold and getting colder. When you are hungry, you don't get more hungry. You're just hungry, and if you eat, you'll probably be hungry again in a few hours. So cowboy up.
I am 37 and I’ve never intended to fast but my routine sounds like exactly what he mentioned. I eat once per day, never crave sugar or carbs. Once our body gets used to with the routine, my mind listens to my body instead of the other way around. It’s so important that we understand our body & listen to it because our body is science itself.
I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew!
Most of the more severe illnesses happen to people because an upsetting event occurs in their lives taking them by surprise, unexpectedly, impacting first in the brain, then in the corresponding organ which that part of the brain controls. The end of WWI had absolutely everything to do with the Flu and lung TB outbreak that occurred killing millions. In nature, the biological conflict linked with a territorial fear (just what it means-a fear in your territory, your home, your community, etc.) is a widening of the bronchia (tissue loss). Your body attempts to widen your bronchia in order to allow more air into your lungs to give you more strength and energy to fight to keep your territory safe. Stay with me.......The biological conflict linked with a death fright impacts the lungs. The lungs attempt to grow larger in order to allow more air in because breath equals life, as we all know. No breath equals death.
While you are in the fear or death fright conflict, you notice no symptoms of “disease”, except you have cold hands, cold feet, you can’t sleep, you awaken at 3 AM every night, you have little appetite. During the war, millions of people were in fear of the bombing of their homes and cities where the war was most active. Fearing for their lives, their loved ones in the war, their ability to survive. The food in the stores was sparse due to shortages. This lasted for 4 long years! The longer the conflict, the worse the healing phase. Within 2 weeks of the German Chancellor announcing the end of WWI, these millions of people ALL went into the healing phase all at the same time. It is during the healing phase that you experience symptoms of illness! What is the healing phase of the bronchia widening? Severe bronchitis, pneumonia. The body attempts to refill this lost tissue and you experience inflammation, fever, coughing, body aches, fatigue, etc. What is the healing phase of the extra lung tissue that grew? Decomposing of the tissue by TB bacteria and fungi. The symptoms of this healing phase are: severe coughing up of blood and tissue, fever, inflammation, severe mucous, body aches, fatigue. During this decomposing of the extra tissue (tumor), the body expels a lot of protein, and without replenishment, severe protein loss can result in death. Antibiotics did not exist yet. If TB bacteria does not exist in a person or they have been vaccinated against TB (big mistake), then the tumor will simply encapsulate and become dormant and not harm you. Who died during the Spanish Flu? Mainly the poor who could not afford to buy meat and proper nourishment, and the people who were directly impacted by the bombings and destruction of their homes.
Millions of people suffered fear and death frights during the fighting of WWI, and millions of people all went into healing at the end of it. Not everyone was affected because not everyone suffered the same way.
It’s not a “flu”, it’s not something you “catch”. It’s biological, meaningful, and unavoidable. One hundred years later, a Fear Campaign begins, using the media to spread it......
Me too, I knew it was gonna happen before the end of 2021
it was recorded in mid summer so it already happend a while ago
This channel/show is a gift to mankind and we should be forever grateful to this man
100% feel you. I am blown away when I share this podcast with others and they don't tune in
Thanking you very much for your brilliant work on genetic influences attaining fountain back to youth so to speak .people close to me are astonished at the bullet proof genetics I was blessed with I just turned,60 don't look day over 40 literally lived the life of a rockstar rarely ate and when I wasn't obliterated it was all about adrenaline surf snow skydiving racing motorcycles cars . never seen a depressed person dropping into 20ft wave wondering if adrenaline has benefits slowing deterioration of are meat suites
I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.
Same here, 60 with 92 yo mom & 14 yo border collie. Learned applicable lessons for us all! Most appreciative 🧘♀️🚴♀️🧗♀️🚣♂️
Your mom had you at 40? That's amazing by itself.
Could you share with us what they say their "secrets" are to living a long life? 🙏
@@nebber1234 In the first place, the “infertile by 36” data comes from a really high-mortality time and place 😂
@@nebber1234 Actually my grandmother, who was born in 1884, had my aunt at 36 and my mom at 38. I had my daughter at 40 and our son at 43.
High level dialogue. I read the book Livespan before. So this conversation really added value to the book. Thank you very much gentlemen 😊
I’m 35 now and starting to see and feel it. I swear I was 22 just yesterday. Time flies!
Funny, I'm 68 and 22 lives on inside, believe me and hope it never fades. Music is a great way of hold on to that time of your life.
same here bro but I look amazing xd
Tell me about it...not only did I just turn 34 but now I look just like my mom.
@chevalier577 tell us more
I'll be 37 next month time does go way to fast but at the same time I believe aging will be cured by 2035.
What a difference it makes to have well practiced professors explain these ideas! This is such a gift.
After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life.
Thank you so much for introducing us to his work!
Just ordered mine now!
are you going to take metaformin
nice advertisement. did they pay you to write it ? because that also just happens to be a fact in commment with this type of weird doctors
Is it a tough read? And how long did it take you to finish it?
@@xxcorrosive Not a tough read, in fact there are illustrations and Dr. Sinclair isn't pompous or evangelical, in fact he's pretty humorous at times. I'm still reading it, because I skip around a lot of books at once, and even within the book.
Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.
It sure is .I've been through it, and it's horrible. I didn't take any hormones, etc, but I have autoimmune disorder, etc. I have reversed so much on my own. Your skin dries out, our moods change,gain weight ,allergies,incontinence decresed libido and our bone density changed.Sleep changes, burning mouth, dizziness, breast tenderness, osteoarthritis, my nails started breaking off, IBS ,changes in taste, food cravings, bloating, itchiness, I had severe joint pain ,electric shock feelings ,pins and needles, mood swings, hot flashes, heart racing/ irregular heartbeat, and sweating in the middle of the night to shivering. Irritatable and feeling really flushed.Memory, anxiety, panic attacks , and brain fog are similar to my fibromyalgia, CFS. Men don't realize the hell we go through, but they aren't mind readers either, so I appreciate your comment. It's when they read about what the women in their lives are going through, they start to think wow it's a lot.,Some women are so busy they don't even realize they are suffering, and some don't say a word ,leaving their male family's wondering what's happened. If they could experience a day in our shoes ,I think they would be shocked. We go through a lot. I've recently started taking NMN. I have energy and I thought I was losing my hearing because I kept saying can you turn the radio down etc but my hearing was not working properly before. Now I realize I can hear so much better, I wore glasses being near sighted I couldn't see far away,and as we age bi focals come in and we turn into our local librarian . So i do the test and it comes back saying your eyesight is way better and you only need glasses to drive to see long distances. So my energy from NMN,TMG,my eyesight is better,my hearing is sensitive, now i just have to work on these D knees. 😂
Thank you Dr. Sinclair and Dr. Huberman for all you've done and do! We appreciate you 🙏
Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier.
Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you.
You should probably look at "Why We Sleep" by Alexey Guzey. TH-cam doesn't allow links but he implicates that the book is riddled with errors.
It’s always nice to come across someone else that this podcast is helping. Thanks for sharing, and good luck going forward. I feel pretty certain stories like yours are what they hoped to create when they kicked the podcast off. 👍🏻
@@nikos4641 what’re alexey’s certifications? Is he even qualified to try and discredit Dr. Walkers book? I highly doubt it
Burnt Toast I’m confused why qualifications matter; he just cites the relevant literature that goes against his claims.
Congratulations on your progress. Two books that I'd recommend: Spark by John J. Ratey, MD and Dopamine Nation by Dr. Anna Lembke. Godspeed!
I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️
I couldnt agree more!
Lol, it really does feel that way. Tossing my multivitamin today. Too much iron!
@@CertainExposures Me too!
Oh girl don't lie, you wish he was more than just a friend.
Hey Jessika, I gotta say…you are simply gorgeous! Nothing creepy…just a compliment!
This is gold… I am 48 and started taking AG1 and NMN and I got pregnant…. Nothing else had changed except those two things! … I did lose the baby at 3 months but I understand the body will do what the body wants… the key is consistency!
Awesome!!! Gives me hope, I'm all about supplementation, may I please ask- What BRAND/TYPE of NMN??
@@roxypedro100 Renue By Science
@@lisabrown3015 THANK YOU LISA 🥰 i'm going to try that one!!
For someone who's 52 yrs old and looking like that, Dr. Sinclair's an excellent ambassador for anti-aging science.
He's done botox tho
@@jonluis2647 are you sure?
@@jonluis2647 He said on Joe Rogan that he hasn’t done Botox
He looks every bit of 52.. However, maybe if he wasn't taking all of his anti-aging supplements and taking care of himself, he would look older than that
@@TheSweetvyc bruh have u seen most 50 year olds?
The internet creates a spawn of information, but information isn't intelligence. Thank you for continually putting out a sense of logical thought and allowing the public to sit in on conversational engagements between intellectuals like this. Excellent work.
This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done!
Comment on the first minute (before watching it all): For over 3.500 years Chinese culture knows about longevity and slowing down the aging proces by prevention, medicine and health-care. Think (but not alone) QiGong, Tai Chi, Tai Yin (Chinese Yoga), Kung Fu, acupuncture, Tui Na (massage and manual therapy), cupping, plants and herbs, and so on. Based on YinYang and or 5 Elements, An integral and holistic approach for health including reversing / slowing down aging. Just start with what resonates with you, get some intel and go from there. You won't regret it.
Having said that, iam gonna watch the vid now ;-)
And many thanks for Andrew Huberman for his -free- series on health. I've learned a lot 🙏
I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done.
I’ve drank heavily. HEAVILY for at least 20 years. Not because I enjoy it, but because my anxiety problem is very temporarily masked by it (but also exacerbated by it). I’m 38 in a couple of weeks and I’m terrified that it’s going to hit me very soon and I’m gonna be very ill or look like a haggard old prune in the near future. 2023 is my goal to do at least 4 weeks abstinence from alcohol because of another of Dr Huberman’s videos on dopamine which perfectly described my affliction with alcohol use.
I love Dave. He is such a smart guy, has a great sense of humor and he is able to break down complicated subjects in easy to understand pieces.
Dear Andrew,
I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!
I love how you encourage other scientists to start their podcasts! But also episodes with guests, no matter how interesting they are, just make me appreciate episodes fully conducted by you. I love the logic in the sentences.. it’s so pleasurable to follow🤤
Trace that back to Lex and Lex back to Joe.
So many puzzles untangled by science...the beat goes on!
Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies.
This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work
Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us!
LMAO!
Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done!
Going to buy the book. Insane podcast. I didn't take him seriously until I knew he was 52.
Botox tends to have that effect.
Wow kinda surprised to see you here. Make a post on FB about this too and even this might trigger a few lol.
Keep in mind that he has access to high level professional tests any time he wants to optimize how he interacts the world. This is not available to most.
@@RunOfTheTrill what makes you think he's had injections?
Really I think he looks in his 50s
I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing.
Only trust yourself... YOU are the expert on your body, if it feels off, it is.
Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving!
😂 😂 😂
🤔🤔🤔
You should really do a parachute tandem jump. It is an unforgettable experience.
What an amazing podcast! I've watched dozens of interviews with David Sinclair. Dr. Huberman asked different and intriguing questions that no one else has asked before. Two brilliant and forward thinking scientists together, sharing provocative ideas and insights. This podcast gets my vote for "best of 2021". Thank you!!!!i
Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!!
I believe this is the 7th episode I'm listening to, in the past 4 days. Thank you again, Mr Huberman!
I could listen to you both for hours! Videos like make TH-cam worthwhile.
I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic!
Me too, stop shouting! 😘
What were the dietary modifications? Thanks 😊
@@mermaid5948 according to Sinclair: Metformin, Botox, Spermidine, yogurt & plants.
We Are being lied for many years.He actually pointed it out that living longer is connected to eating less which was ignored by the medic world no wonder why
My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans.
This is still better than any movie released since this episode. Such a high repeat value I can watch it for fun sadly not with popcorns, two of my most fav scientists today
maybe do it with yoghurt + resveratrol
Yessss
@@shabuqazi86 p
I have been completely ignoring movies since I found this channel.
Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen.
It's insane to think about how much more medical/life changing information has been discovered/is known around the world but is still not a common part of everyones daily lives... What a wonderful world this could be...
I'm not sure humans not ageing would be as fantastic as it sounds. I could think of lots of draw backs in fact.
@@chadspro You’re probably talking about resource allocation, over population, increased disease, etc.. and you’re probably right. But I’m a bit of an optimist and believe that there is a Pugh resources to handle quite a bit more people, however, people would need to learn how to be more resourceful, live a life of less waste, learn how to provide for themselves, etc.. Essentially, I believe it’s possible that we could live longer and in a larger population while staying in harmony with the nature.
@@chadspro chad slo the dangerous kind
Lifespan and intelligence engineering are both needed.
Chad nah
Absolutely LOVE how Dr. Huberman handles this - he carefully brings out all the right things. Fantastic interview!
I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview.
The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things.
1:12:37 Ui❤ 1:12:38 🎉u yi❤
My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️
Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol
Wow, this podcast is just getting better and better!
I'd love to see a podcast on Discipline and raising conscientiousness.
Such a great idea, after having the 3rd percentil on the Jordan Peterson's personnality test in conscientiousness, I need help 😂
@@MMyL7 lol same here
Yes, yes, yes
The advice is essentially to have a long term plan (future authoring can help with this - I got it, it's pretty good), make a schedule (Google calendar is fine to use), try following it alittle more than the day before, start small you will improve.
Paraphrasing, he said more but that's all I remember and it's pretty useful imo.
@@samuraiyun219 wow thank you!
I can't even dare to explain how valuable this podcast was. Thank you very much! I would also LOVE to listen to your philosophical conservation. Please consider that. The youth/future needs real influencers like you guys!
This is going to sound backwards but seeing this makes me grateful for that anorexia diagnosis in high school. I’m saying this on the other end of it, as a middle-ish aged woman, and forever grateful that I survived and recovered, but glad to know that there was likely a silver lining to that hell.
Do you think you look younger than you should? Or do you think it might have helped longevity in the future
@@FriendMariaAdrianna longevity. I think I look my age but I am pretty fit and healthy overall in comparison to what I hear from a lot of my peers. I also have 3 kids and a full time job at this point so I think the wear and tear is equivalent.
Stuff like this is a representation of some of best attributes of our species. Thank you doctors for sharing your knowledge!!
One of most productive talk from two great scientists in our generation. Thank you from Australia 🇦🇺
Good Day
How's life in Australia?
Are you looking younger than your age,?
@@jessesolomon6700 na Austrália as aranhas são gigantes e comem pessoas. Para escapar ajith finge ser um cachorro. Olhe a foto dele.
@@Rafas216
English please.
@@jessesolomon6700 fucking oath we all are 🎉🎉 excellent vitamin D is the trick 👌
@@lukekennedy2410
We who?
Best ever. I nerd out trying to figure out my ADHD brain and my genetics from my 23 and me data through other companies. I’m a 51 yr old female and people think I’m 35. I’m so signing up on Dr Sinclair’s website!! Thank you for this amazing podcast!!!
Really??? How do you look so young! 🥺
@@isabellalora6533 maybe because I blocked my face from the sun since age 23. I saw all my sun loving friends aging back then. My grandpa always pushed Vit C too. And maybe genetics played a huge part. I have no forehead wrinkles nor 11 lines between eyes. Only thing that shows a little age is under my eyes here and there on bad days.
@@jezebellab1779 wowww!! Incredible! :)
I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much!
I'm intrigued to hear Dr Sinclair's podcast when it comes out! It is great to see scientific research presented in such an engaging manner.
Same i hope he has lil xan on
Your show is awesome
@@BarsandNightclubsAU thank you
same here but i wish we get more clarity on resveratrol because according to Dr brad and multiple others doctors suggesting not to take resveratrol, hopefully we will get more clarity from huberman or sinclair soon
@@Chrissssk if you don't want to take resveratrol, just take olive oil. NMN + olive oil works good for me. I'm 37, I weigh 93kg (admittedly I exercise hard 5 times a week) and my resting heart rate is 47.
The whole podcast is excellent! Weird/interesting about people ingesting Methylene blue. True story: About 9 years ago, our son was using his microscope set and had powdered methylene blue for his slides. Unfortunately, our rat terrier got into it, and knocked over and ate some of the methylene blue and caused it to get airborne. For days we found deep blue blooms of it all over our white tile floor. We took her to the vet, and found out that methylene blue is given to dogs when they have Tylenol/acetaminophen poisoning and have developed Methemoglobinemia. Our rat terrier was fine (and is still fine), though she had dyed her insides and created a lot of work for this gal.
Another fantastic podcast! Learned so much!
We’re truly in the future. Free info from the very best. Thank you Drs!
Thank you very much for this. What a great podcast. Learned so much. Grateful for your work.
I would be very interested in an episode about funghi (lions mane, chaga, reishi, cordyceps etc.)
And what they can do in relation to longevity.
Thanks a lot, very great content.
This is the best Sinclair interview I have seen. Seemed super relaxed and glad to be there and share with someone he consider a peer.
What a brilliant podcast! In absolute awe - extremely grateful to you both for your service to humanity and your commitment to educating the public! loved this.
Quite the opposite. Filling your silly brain with nonsense and bro-science
thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons.
When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.
it's funny my grandmother never had a highschool diploma let alone a PHD in Neuroscience or biology or anything else, She ate in moderation, enjoyed good food , enjoyed bad food , she danced was active , loved family and friends dearly , and had a great outlook on life! Also she never drank alcohol much , and never smoked , lived to past 94 years old , this is the template for a healthy long robust life,
That’s my base strategy as well. Still open for some scientific tips and tricks to increase my healthy lifespan.
Happy new year Dr. Andrew! 🥳Thanks for the life-changing lessons in 2021 🙏 Can’t wait to see what you have in store for 2022 🌟
I have been following David Sinclair for few months now and he has been interviewed by very smart guys here on youtube, but this was his best interview ever. Great job Andrew, You asked him some amazing questions, this is very educational, I am going to follow you closely from now on.
When Dr. Sinclair said he was proud of your accomplishments, you breezed past it and changed the subject. My best suggestion, is next time you receive a compliment, take a deep breath (I know you're big on that) take it all in. Just absorb it, and take a moment to enjoy it, knowing how much you've earned these acknowledgements. Just my thoughts. Thank you so much for what you bring to the table, I appreciate you so much!
One of the all time greatest podcasts in relation to health and longevity. Thank you guys.
May God bless you Andrew Sir.You are like modern Prometheus,bringing flame of knowledge to us.
Sorry, WHAT? I had to rewind that... did he just say he's 52?! This man does not look a day over 30! Since turning 40 six month ago, I've become much more mindful of my overall health, I've increased excercise, put more thought into my diet, my sleep habits and cut out alcohol (having reduced from drinking 2 nights a week, to 1 night, to once a fortnight, to once a month, to once a quarter). I'm naturally slim and have never eaten more than 2 meals a day, usually just 1. Dr Hubermans podcasts have had a real positive impact on my life, and this one didn't disappoint. Thank you gentlemen 🤍
Please don’t be a liar 🤥 he looks good but on his 50’s
@@RuthGarcia-vs5jv
No, he looks 40.
Idk what 50 year olds you’re interacting with. 😂
@@RuthGarcia-vs5jv 40s
@@RuthGarcia-vs5jvplease don’t be a hater… would you guess 52? no let’s keep it real . He looks 10-15 years younger
This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions
Thank you Andrew for all informations! I will try to do so as much as posible. I wish to look young as Dr.Sinclair who is 52!!! Awesome!
Great podcast! I always love to hear what David has to say and you Andrew ask all the right questions.
This was a phenomenal discussion. Thank you both for your time, your knowledge, and your dream to bring your knowledge to the masses.
I took resveratrol because of his research in the 2000s in my early 30s. I had a critically bad response and all of my tendons became really weak and I had massive onset of what felt like arthritis throughout my body. I was on the Imminst/Longecity forums back then and there was a subset of people on resveratrol who had very bad tendon responses. Sometimes they would just get up out of their chair and rip their Achilles tendons. Never touched resveratrol since then and it took years to recover, and I don't think I ever fully did.
Thank you for this info. It put me off that’s for sure.
I hope you see this, you could have had a herx reaction because resveratrol is used to treat Lyme disease. 14% of the world population has it you should test for it. Lyme in particular causes the “feel worse” and the symptoms you described are textbook herx symptoms
Resveratrol may cause copper deficiency
Sinclair's reservatrol has come under heavy criticism by the scientists and the positive effects interpreted was considered false. This came out AFTER all the hype and after he sold his reservatrol company for $720M. He bevere apologized or recanted his suggestion
Something no one talks about is indoor air quality. The last 100 years we have built more and more air tight homes. High C02, VOC’s, and particulates are causing short and long term health conditions. I was one of them. We had to add ventilation to our home because I couldn’t sleep due to discomfort. Once we did that, I can now sleep well and I feel much better overall! It plays a big part in how we feel. But, you can’t see it so no one cares. But, we breathe 40lbs of air per day.
I’m a residential contractor. New building codes require supplemental air exchange for new construction… hopefully this will help with the poisons in the residential air 👍
I’d really love to know more about fasting and women’s health, particularly during peri/menopause.
I’ve done IF once, for 6 weeks, and my hormones became imbalanced, I gained weight, and lost my hunger cues and overall appetite. My overall calories were appropriate and I was getting optimal nutrition.
I suspect there was something in the particular IF pattern I was using that was ill-suited to my physiology. But I’d like the health-benefits of it.
Is there any literature on IF for women in or nearing menopause?
Kristy Dr. Mindy Pelz is an expert in the area of women’s hormones and fasting. She has an excellent TH-cam channel. I hope this helps 😌
Thank you for this. I came here to write something similar, including peri/menopause but also extended to various aspects of women's health. What cautions or considerations if trying to get pregnant, or pregnant, or breastfeeding, or with tendencies towards eating disorders (more prevalent in women), etc.? There is overlap with men, but SO many differences. Though I appreciate the portion in the podcast on fertility. Really interesting.
@@audrey3042 Thank you. Looks good, though I don't see anything in her material about pregnancy, breastfeeding, teenagers, eating disorders, etc. I will do some more poking around.
@@audrey3042 thanks, I'll check it out!
I'm not a woman..nonetheless a human and have experienced similar thing - and HUGE problems with cortisol and arenalin with IF. When I introduced breakfast I actually started loosing weight and experienced less stress and anxiety and better mood.
Oh, my goodness how amazing and informative is this conversation -For me it was a class! I took notes and study every bit of it, it took me two days to actually finish watching the whole conversation.
Thank you both for helping us ask the right questions, and be aware of all the goodness that can helps us do better in our health.
Thank you to yourself and David for your time and to everyone involved in making these happen as ever !
I can’t believe this content is free. Thanks docs!
What a treat! My two favorite scientists! :) Thanks so much for being human beings who think outside of the box while keeping your egos in check.
The video starts at 8:00 (for those who want to avoid the advertising and marketing) 😉
I skipped it too!
I am only in 18mins and This conversation is so interesting between two great educated minds. I am hooked, love it already
Oh and NOT drinking alcohol is definitely not boring AT all. Love it
Same here
Dr. Huberman, can you tell us which brand of NMN supplements your sister takes and what dosage she’s found is optimal? In future episodes when you suggest protocols, it would be helpful if you could share which of them (and to what extent) your sister and/or other women in your life also practice. (With their permission of course)
Did you ever find out the answer to your question? I have the same one. Looking for quality supplements is difficult.
@@andreaodney6914 following too
@@ttlkomoloooonu obviously look at his sponsors, athletic greens or whatever
@@andreaodney6914 no answer but there seems to be trouble in at least the NMN supplementation research. @ Physionic just posted a video on the subject. Also the Lifespan podcast with Sinclair doesn’t appear on the scicomm media website anymore so not sure (but kinda sure) what happened there. I could be looking in wrong spot.
@@_negentropy_ Ok, I'm not sure what the scicomm media website is, or what the implication is for it not being there, but maybe I'll check out the physionic video, thanks!
"We'll all be like Dead Pool." The same day I listened to this, my mom commented on my 92 year old step dad's uncanny ability to heal quickly. She was a nurse and nursing instructor and has noticed this ability over their 40 years together.
OMG. JE SUIS TROP HEUREUSE QUE CETTE INTERVIEW AIT LIEU 😭 MERCI
Perfect end of the year, best wishes for this podcast, its crew, and all of the viewers that are interested in science. 🥳
This podcast made an incredible positive impact on my life.! After watching this I started taking NR 600mg a day and experienced an incredible energy boost. I’m 48, juggling a career and two kids. I never had the energy to workout after work and now I have so much energy I WANT to workout everyday! I’m actually running! Something I never did before because I struggled to breathe. The only thing I did before was yoga sporadically and some hiking. I feel younger, healthier and not so concerned about turning 50. My skin has improved too. I feel like I’m changing from the inside out.
I’ve been eating OMAD 4 days a week for a couple of years. Since these guys take AGI also started taking it after introducing NR. I recently added NMN and I can feel the difference when I added that too! So much energy it’s life changing!
Also my chronic neck pain went away and I sleep better too.
Oh and I started my 87y/o mom in NR and she keeps asking me for more since she’s been feeling more energetic on it as well.
Thank you so much for sharing this scientific information, it had been life changing implementing what I’ve learned from this.
Please what is NR
It’s an NAD booster, Nicotinamide Riboside. I’ve switched to NMN which also works great.
what a time to access knowledge, narration as easy as it gets and being accessible to those who seek!! thank you.
I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated.
Great info
Tks
So much
Q
Great content. Unfortunately, I have to skip ads when watching but whenever I have to think about the information I let the ads run as I can't have the ads interrupt my thoughts. Also, if there was summary notes about the key topics (supplements, time of use etc) the podcast/channel will be god-tier level. Keep up the good work Dr Huberman.
Pay for TH-cam ad free 🤷🏽♂️🤦🏽♂️
I have to say that the obvious enthusiasm and excitement you both show as you discuss these topics is absolutely wonderful.
I've had a mental note for weeks to request Dr Sinclair as a guest...and you beat me to it. This is amazing information - thank you! Also, an observation (which, no doubt, many people make): I am reminded how very youthful Dr S looks. Seriously - does he not look like he is in his early 30's or even younger???
He absolutely looks in his 50s, but healthy for sure :)
I swear, each time I see him he looks younger.
@@AlexanderMoen if people think he "looks" his age, I just don't see it. I, too, am in my 50s. What strikes me is that he has little to no gray hair, smooth unlined skin and a boyish body. Unless filming techniques are hiding something, I think if I walked by him on a sidewalk, I would guess-ti-mate him to be in his 30's.
I think he mentioned he tested his biological age(horvath clock or something) , and he is actually 30 something year old biologically.