How do allergy shots work? | Th2 cells and IgE
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- เผยแพร่เมื่อ 28 พ.ค. 2024
- How do allergy shots work? Allergy shots work by stopping Th2 cells from making IgE antibodies. The goal of Allergy shot immunotherapy is to change Th2 cells into Th1 or Treg cells. This way IgE antibodies are decreased. If IgE antibodies are decreased then your main allergy cells, the mast cell, cannot function and release histamine. Histamine is one of the main molecules responsible for allergy (runny nose, itchy eyes, hives, swollen throat). Allergy shots, or allergy immunotherapy, can help many people decrease their allergy responses. Although not everyone will respond to this type of treatment. Often adults with peanut allergy have such severe symptoms that they do not benefit from allergy shots. However, many other types of allergies can be improved with allergy shots over the course of a year. If you have any other questions please leave them in the comments section! I would be happy to go into additional details.
Sources:
www.ncbi.nlm.nih.gov/pmc/arti...
www.jacionline.org/article/S0... - วิทยาศาสตร์และเทคโนโลยี
When one is both a scientist and a visual artist at heart you get amazing videos like this!
Thanks for this video! I didn't want to take the shots until I understood how they work, and the allergist did not make any effort to explain things scientifically.The idea of building a tolerance and overcoming the allergy seemed to be far too simplified to actually explain anything at all- so this breakdown of what's actually going on was so helpful!
I'm the same. Had to research about it first. I'm about to start the journey as well.
Thanks so much. I have horrible oral allergy syndrome and environmental allergies. I worked at an ENT clinic that did allergy shots and the docs didn’t quite get it to this level. They gave me meta-analysis papers to read and all I took from it is that you want to build up IgG to outcompete IgE. I didn’t realize all the other parts, and I’m sure there’s still more. Thank you for these great videos I really learn so much
I'm sorry you are in the horrible allergy club too. I do really appreciate what you said. It makes me really happy as a teacher!
This is one of the best explanations of how allergy shots work. Thanks for making this video!
Wonderful job explaining and illustrating! Thanks! The therapy is working for me!
Amazing video!! 👏 👏 Subscribed!
Amazing explanation! 😊 thanks for making it so easy to understand
Thanks very much, excellent video. Super informative and entertaining!
Thank you! This was so informative. Now, I understand this so much better😊
Thank you for clearing this up for me
This was the best explanation yet. You made a complex process understandable. Besides that your art work is amazing. Thanks so much for this presentation.
This was very informative, being consistent has been the most challenging thing for me, as an adult that works full-time. Hopefully, I'll be finished with my injections by September of 2023, I was curious how these injections work. Your video did a good job of explaining it to me.
best explanation by far
Why doesnt exposure to allergens outside increase tolerance over time though? What is different about the shot?
Thank you so much for your amazing video. I have a few questions but 1. how does the macrophage pick up the sesame molecule? Does it imply leaky gut? 2. What is the difference in low level immune system between allergy as in this case and intolerance? Thank you again for your wonderful videos.
Brilliant explanation of such a complicated concept. Hats off to you. Love from India! ❤
I kept smiling the entire video! You sound so happy explaining this from your heart! I’ve always loved medicine and immunology, and unfortunately I have chronic allergic rhinitis. Did the surgery, and it still came back, went back to abusing Otrivin, but now I am finally taking the SCIT allergy shot Thanks for the video! It really helped me understand!
How is it now my friend 😢, i just do blood test for allergies and i found my allergy in high rate. I wonder how the shot work and does it work?
Is SCIT helping you?
As someone who's allergic to pretty well all of nature and started shots a few months ago this is really informative
Have you experience any improvement yet??
Explained in very simple way 🙌 watching from india❤
Can you make a video about eosinophils in the nasal tissues and their interaction with goblet cells and their role in allergic rhinitis? Also, the idea for a video about t cells talking to b cells and isotype switching sounds super interesting. Also, have you heard of intralymphatic i immunotherapy and could you make a video about that?
Thanks for the video. I’m almost at the maintenance phase of my shots. However, I feel lethargic and feel slightly asthmatic this early into it.
Can you give some insight on what to expect during the journey?
I think I can never eat sesame again after seeing this video
Thank you!
Thanks for the great explanation. For someone starting allergy shots, are there any practices that we can take to compliment or improve their effectiveness? You mentioned reducing inflammation- are there practical things we can do to accomplish this?
Also is it a bad idea to start allergy shots during allergy season when one is already experiencing allergic responses and heightened inflammation?
I also want to know this :(
You are so smart and enjoyed your video and drawings. Its good to see a fellow halfie contributing educating others on such an under represented area of medicine.
Nice video. Could you explain what you mean by inflamation? Is eczema on skin considered inflamation?
Yes.
Any anti-inflammatory that can be taken with allergy shots?
Great video. But I don't know what any of this means. But please make my allergies stop.
Thanks for this great explanation. Would allergy immunotherapy work for someone who has lupus, or chronic fatigue syndrome? I guess I'm looking for more detail around what happens if the person has some chronic inflammation
I developed a chronic inflammatory disease called Polychondritis with renal involvement after receiving these vaccines for 1 year, allergen immunotherapy activates the Th1 and TGF-β , which is responsible for the pathogenesis of many inflammatory diseases, there are cases of lupus development in people who have used allergy vaccines In my experience, the best thing you can do is ask both your rheumatologist and allergist to work together.
My health was destroyed by these allergy shots.
Does it affect testosterone negatively? Or induce hair-loss etc. thats the questions I cant find answers to.
Mam, Will the tolerance be permanent?
Is this also how bee allergy shots work? I’m going thru that right now and trying to figure out what is going on. 😊
I get terrible asthma when around a dog…would immunotherapy completely fix that ?
Yes dog dander sublingual treatment can help with that.
How to make vaccine at home?
My covid igm is positive for the last 9 months and no one knows why. My igg and pcr is always negative
Realizing that inflammation is causing most of humans health issues.
Do allergy shots interfere with immune function in a way that compromises it against real threats?
Can allergic shots (for cat allergies) activate an autoimmune diseases?
I suffer from Relapsing Polychondritis, an immune-mediated inflammatory disease, I developed the disease at the age of 13 in the distant 2002 during the application of allergen-specific immunotherapy (SIT).
Because allergen-specific immunotherapy causes changes in the immune system, it is possible that it may influence the induction of diseases mediated by the immune system, such as autoimmune diseases, even some doctors point to the induction of autoimmunity as one of the possible consequences of long term of the SIT. It appears that increased concentrations of IL-10 and TGF-B, as well as changes in the Th2/Th1 balance, could lead to autoimmune problems in people undergoing SIT. Relapsing Polychondritis is a Th1-mediated condition.
In the medical literature there are several cases published over several years such as that of Dr. Ghorschi et al, “Manifestation of rheumatoid arthritis during subcutaneous allergen-specific immunotherapy”, “Scleroderma related to specific immunotherapy. Maciel BM Clinical Case, Morphine BM.” “Turkcapar N, M. Sjogren’s syndrome induced by specific immunotherapy.”, Pemphigoid-like reaction by allergen-specific immunotherapy: an unusual adverse reaction Margarita Tomás-Pérez, among others.
The MDs, PhDs. Allan Linneberg and Andrzej Bozek carried out investigations where the cases of autoimmune disease that have occurred during or after the application of Specific Immunotherapy published in the medical literature are pointed out, their conclusion is that the development of autoimmune diseases in patients with allergic diseases undergoing SIT it is rare, but as a precautionary principle it is extremely important to evaluate people in terms of the risk of autoimmunity before the application of allergen-specific immunotherapy.
There are several cases of people who have developed autoimmune diseases during this treatment, many of these cases have not been published, and as Dr. Linneberg mentions, it is a sensitive issue that important measures must be taken.
In the main guidelines for the use of specific immunotherapy, such as the EAACI and the DGAKI, this delicate topic is mentioned.
Research and published cases acknowledge the great ignorance and uncertainty that prevails in this area and calls for a strong precautionary principle in relation to allergen-specific immunotherapy and the risk of autoimmune diseases.
I was treated negligently by an allergist member of the National Council of Clinical Immunology and Allergy (CONICA) in Mexico, my case was not published in the literature.
@@carlosromancastaneda1138 wow Im sorry this happened to you..thank you very much for taking the time to write such detailed response..I am sure it will help many people who read this..bless you and if you speak spanish like I do muchas gracias y cuidese..mejor lo mas naural posible para no enfermamos de esa manera 💕
@@isabellashirahmadi5704 Muchas gracias!!!
@@carlosromancastaneda1138 It's awful to hear what you are going through, hope you are able to keep it under control. I am reading that this is a risk only for those who are already diagnosed with rheumatic autoimmune diseases (RAD). Were you already suffering from that when you started AIT/SIT?
My understanding is Allergy shots don't include food items. So, why are you mentioning foods?
They are only to treat environmental Allergens.
There are sublingual drops that might include food allergens.
Do allergy shots merely repress immune system or reprogram it from step one?
I think it’s more like teaching your immune system ‘hey, look, this allergen doesn’t actually pose a threat, so chill’
Do mast cells do anything but cause misery? Must they exist?
IgG4 is such a wonderful antibody. The people who got at least 3 mRna shots are so lucky to have millions of these protecting them from covid!
Still got it twice, it was awful. I guess my body just overreacts to everything. Too much inflammation probably
@@theunseen3 I was being sarcastic. The mrna shots are a gigantic shitshow.
I'm very angry nobody is mentioning her beauty. What a beautiful soul😊😊
Quit being so smart. Jk good video
I stop watching at the beginning of the video because you’re being unfair to animals and plants (ink & paper) to explain.
Alright I will remove the video for you
The process only takes a month with sublingual treatment which makes SLIT superior to SLIT.