How does the COVID mRNA Vaccine work?
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- เผยแพร่เมื่อ 14 พ.ค. 2024
- Hi! I'm a PhD and I will draw how regular vaccines work and compare that to how the COVID-19 mRNA vaccine works. I have studied the immune system for 14 years and I want to share my immune knowledge with you! There is also a quick Pros and Cons list at the end. #bobrossvibes
#COVID19
#COVID19vaccine
Also sorry Potatoes you are an excellent food with no preservatives!
P.S. Not all potato chips or breakfast cereals have preservatives! Mini wheats added preservatives recently (BHT), but most cereals do not contain them. - วิทยาศาสตร์และเทคโนโลยี
Saw your Novavax vid first and after these two I just want to say: A star is born!
Your ability to inform via sketch & explain is a breath of fresh air, will educate many and even inspire some youngsters to follow in your footsteps I'm pretty sure.
👏👏👏👏👏
Long may your new channel thrive!
And yes, when time permits, a trip down cancer alley would be very informative. Would provide great opportunity to cover HPV & prostate.
Thank you so much! It really motivates me to keep making videos when people say they are helpful. I will circle back to more cancer related topics in future!
Have u not seen the many serious side effects from these covid vaccines , many Drs who r not bought off r talking how dangerous they r
@@christinehorniman9229 of course we have...long ago. But that doesn't detract from the fact that she has a knack for explaining a complex topic with great clarity. And maybe Novavax will be less dangerous...we'll wait for more data to see.
These videos show possibility of explaining immune system details. From my perspective Dr Faucii never explained immune system details other than broken record of wear mask, social distancing, wash hands. I suppose Faucii had his reasons but his explanation was at a nurse level and poor management in my opinion.
About 1 year after covid start South Korea had 80 times fewer covid deaths versus USA adjusted for population. If USA was successful in copy of Korean response mechanisms, then USA covid death would decrease from 1,000,000 dead / 80 to 12,500 dead. From my viewpoint not explaining choices with Korean mechanisms and results means death of those with weaker immune system is acceptable.
Love your drawings! I can understand your explanations of topics so well! It makes so much sense...thank you.
Great vid! Few questions:
1. What are the effects of MRNA vaccines on cells other than macrophages?
2. Why "no virus particles" a pro?
3. Do we know now how long the antibodies last with MRNA vaccines?
4. Is there a link between MRNA vaccines and variants?
Thanks for your feedback!
THANK YOU VERY MUCH for your videos. 🙏 I have only found too easy or too difficult information about this topic. Yours is perfect for interested people with no medical background. 👏👏👏
I already shared your video with my sister and my mom. I also watched your original previous Covid mRNA video. Thank you for giving honest information. It is good to see you gave an honest answer to whether or not long term effects are known and that it hasn't been tested on the pregnant. The more you are honest and open with people, the more people will be willing to listen and trust you.
Thank you very much.
This is amazing! Wonderful lesson! Thank you so much! 🙏
Glad you liked it!
Are you sure?
th-cam.com/users/shortsM0UKBzM4kXQ?feature=share
PLEASE WAKE UP
@@thechosen4403 I am not sleeping and I hates dirty click bait. So, no click on your link from me.
Amazing! Thanks for the info! Hope you make more!
Thanks Jair! Any requests?
Your videos are gold, so well explained that the average person can get it. What I can’t believe is less than 1000 subscribers. Makes sense when you see how many people are blindly following whatever crap the government spews out… Love your work 👌🏻
Thank you for your kind words! I’m a new channel been around about 4 months. I read it takes an average of 22 months to hit 1000 subs, so I feel really quite lucky.
This is very well done, easy to understand, and informative! I second drawings of cancer and the immune system although I understand doing a few more COVID ones first.
Thanks so much! I will definitely make a cancer video soon.
Your a great communicator and a natural teacher. Thank you. Keep going.
Thank you so much! I do really need the encouragment.
Thank you so much for your video. It is very easy to tell you are genuine and are wanting to help people understand one of the most complex parts of the human body, being the immune system. Einstein once said “ If you can't explain it simply, you don't understand it well enough.”
You clearly understand what you are talking about and can simply explain it in a way that can be easily understood.
Thank you for taking your time to explain this video and your others, I along with thousands of others appreciate your dedication to your chosen field.
That is one of my absolute favorite quotes. Thank you
@@friendlyneighborhoodimmuno7192 you’re welcome.
@@friendlyneighborhoodimmuno7192 agree above. This is great and loving watching your videos
Very informative video! Thank you! Regarding the cons - the long term efects are not likely but in witch time frame can they happen? Is it enough the time we had until now or that can take years?
This is amazing!!!
Thanks so much!
Thank you.
You did amazing!!! Miss you lady. Would love to hear about endometriosis if you have any information on that.
Thanks Katie! I have added Endometriosis to the short list.
Great video, thank you for sharing.
Thank you!
This is such greatness 🔥
Thank you so much!
Well done in explaining this. You deserve way more views as it's such a good foundation for cutting through all the misinformation circulating around!
I'm still pondering on why the efficacies start dropping in 6 to 9 months. Variants aside, shouldn't our B cell remembers how to produce the right antibodies still? Your explanation will be greatly appreciated!
Keep up the good work
Thank you! I don't have an answer for your excellent question. Many people are working on answering this question. The fine points of B cell memory are an area of active research and not fully known. Perhaps very high levels of antibodies are required to protect from COVID? The data is still coming in as to how long the average vaccinated person will make high levels of antibodies for.
This is by far the best presentation I’ve ever watched. Could you please tell me if being myasthenia gravis patient post thymectomy in remission has an effect on T & B cell function.
Thank you kindly! Yes, it will have an effect on T cells. Since your thymus has been removed you won't be able to make new T cells. The thymus is where your T cells mature. However, you can still make new B cells. You will have all of your older B and T cells. Some of those T cells will be memory T cells and they could be with you for decades.
Awesome
Thankyou mam really knowledgeable for us
Good drawing based educational video on vaccine
Thank you!
Great video so thank you for sharing your expertise. I would really appreciate your thoughts on ADE Antibody Dependent Enhancement (we get Covid because we got the vaccine). Thank you.
Hi Craig, that's a good idea to discuss ADE. It will take me a while to get a video on that together. Maybe in a week or two?
Great question as this is my worry. Confusing it using this new tech and causing ADE or immume disorders escalating in near future
Thank you for this. Great job! I would like to know the difference in the J&J and Moderna. Then I'd like to understand if Novavax is a good replacement. Then I'd like to know if Molnupiravir works and why it costs so much for Americans? i.e. can Merck be trusted. Probably too much - this is my first time seeing you, so if you've covered already then good for you!
J&J = "viral vector" vaccine. So an Adenovirus - causes the common Cold - was modified. They inserted the gene from the Covid virus responsible for spike protein creation into the Adenovirus. Then when it replicates = it has those proteins on its surface. The Adenovirus is then attenuated for use in the vaccine.
Novavax - a "recombinant" vaccine. So they took the Covid spike protein gene and inserted that into some cells to "grow" a bunch of spike protein segments. That is purified to separate out the spike proteins which are used in a vaccine along with an adjuvant.
Moderna/Pfizer = "mRNA vaccines". These take the segment of mRNA responsible for spike protein generation by the ribosomes. It is slightly modified via nucleotide insertion so that it is not an identical copy - but - the resulting spike protein will be morphologically similar to those found on the Covid virus. That mRNA sequence is mixed with Liquid Nanoparticles - basically emulsified cholesterol - to keep the mRNA viable for a time and to allow it to access the cells whose own membranes are also partly made from cholesterol.
All vaccines work upon the same basic principle = introduce "antigens" to your immune cells which react by developing antibodies and seeking out and eliminating any infected cells. They differ in how this "introduction" occurs. Some use the actual organism + a modified organism + the antigenic part of the organism + or the genetic code responsible for causing the cells to produce those antigens. Your immune cells do not "care" which path is taken as they are simply reacting to the presence of something "abnormal".
p.s. - Molnupiravir has a lower efficacy as far as improving your chances of not being hospitalized compared to other drugs like Paxlovid. As such it is not recommended for first line use. It works based upon "substitution". It introduces a drug which when metabolized can be taken up by viruses. Then when they try to make copies of themselves replication errors occur. Think a cake recipe where someone comes and changes the listed ingredients. Then when you try to make a cake = it doesn't turn out right because the wrong ingredients were used.
Yes Merck can be trusted...... Vaccine manufacturers are highly regulated - especially compared to other pharmaceutical companies. This is why by the way only a handful will bother to make vaccines which are sold around the world - meaning lots of oversight by the nations which license them.
Really enjoyed the format and style you brought to this, explaining the complex science in an easy-to-follow way!
I live in Australia and have just become subject to mandatory vaccination orders, so I am trying to accelerate my research into the various vaccines and understand which option may be best for me. Until now I have been hesitant to take any of the options due to a lack of mid- and long-term safety data and the fact that I am a young, healthy individual with a low chance of suffering severe symptoms of COVID if I caught it.
Would you be able to clarify a few things from your video for me, and possibly provide some further information please? :)
When you reached the list of pros and cons, you gave the figure that you are 94-95% less likely to "get COVID" and stay out of the hospital, which is obviously good and seems to be reasonably closely reflected in the other data/studies/research/information I am reading. However I am not entirely clear on your meaning when you say less likely to "get COVID" - I assume your meaning is that you are less likely to develop symptoms of the disease and not that you are less likely to actually contract and become infected by the disease?
The vaccines are designed to minimise viral load and contamination in your body so your symptoms are reduced, not to actually prevent you contracting the disease at all, right? And this reduced viral load is also the reason that the vaccines are said to lower transmission rates as you have less virus physically present infecting your cells and reproducing so you are breathing/coughing/sneezing less out at other people and reducing the risk of passing it on?
My next question related to your point on the mRNA vaccines being essentially pure mRNA. You mentioned that all they contain is the PEG carrier and the RNA coding for the COVID spike protein, but you also said they contain addition sections of proprietary RNA code on either side of the spike protein code which nobody really knows what they do. Your suggestion was that they could be to assist the longevity of the RNA. Are you able to provide any evidence or study into what these proprietary code sequences are or what they do? Given that the ribosomes will process these proprietary sequences as well as the code for the spike protein, I assume they will be trying to produce proteins based on these proprietary codes too. The proprietary sections before and after don't just "drop off" before they hit the ribosome. Do we have any more conclusive data on what the codes or the proteins they produce actually do?
Lastly you have made clear that RNA such as the sequences injected into your body in the vaccine will degrade very quickly by nature, perhaps at longest surviving for 24 hours. What about the proteins produced by the ribosomes after the RNA is processed - how long could these proteins last? You explained how macrophages can take the spike proteins produced to T cells and B cells and form an immune memory potentially lasting months or years which is the point of the vaccine in providing lasting immune effects against COVID. However, couldn't a similar thing happen with the proteins produced by the proprietary code sequences? I would really like to know more about these before I am comfortable having them injected into me.
The Novavax seems like a more traditional option with perhaps fewer of these unknown factors given it introduces copies of the actual spike protein only without additional RNA sequences (have watched your Novavax video, thank you for that too!) but it is not currently available for me and may not be available soon enough to be a realistic option for me.
Any assistance you can provide answering my questions above would be hugely appreciated! Thank you!!! :)
Answer this question.
th-cam.com/users/shortsM0UKBzM4kXQ?feature=share
PLEASE WAKE UP
hi Alex,I hope you are still un vaccinated as you still not having the answer
OMG 😲 obviously, that's specialized knowledge & we need to go to school for that. Well.. . this is where i choose to start my learning. It's the Sesame Street of biological & medical sciences 👏🏻 thank you my dear teacher cum visual artist.
If you want to learn about biology i can recomend klug et al concepts of genetics it is a really well written book
Appreciate this video. Its very well done. Thankyou 🙏
Question: for someone with hyperactive nervous system, autonomic dysfunction and reactions to most medications what would be a more safer option in a general opinion sense. I have a bad gut feeling about MRNA and my immune system doing its job correctly with it and awaiting allergist appointment for other reasons to past severe allergies to such meds and vaccines.. I Feel like it will go off target and set me into a neurological tail spin. I seem to be preferring and feeling more at ease with nova vax (and saw your other video on that too)
The spike proteins is still my concern. Given the spike protein itself has proven to be detrimental to people with either covid or from mrna vaccines where things havnt gone "right" with the mrna process seems to mirror same issues on vascular side effects . If one was to have Vascualr issues already and worsened after what could have possibly been from early pandemic infection and hence are petrified of any spike proteins in the system again on any level. What would you choose 😂? As i seem to really love youre explanations and the drawings are great to understand it all visually but curious which one as an immunologist given the above circumstances you would lean more towards taking. Novavax or mrna ?
Very informative. thank you, but just one question? What is the biodistribution of vaxrevzia vaccine? Does it reach the CNS? Also only dendritic cells get transduced by the viral vector?
@Chris Yong Sorry TH-cam removed your comment but I saw it my email. I think adding links can get your comment removed sometimes. I read the article and they seem to be talking more about how awesome T cells are which is true! T cells are the main reason for long term immune memory. I can’t quite see how the T cell training camp is better at AstraZeneca because the training camp is always in your own lymph nodes. Any vaccine has the potential to give you lifetime immunity. There’s a small case that the viral vector is more likely to kick the immune system into overdrive than the other types of vaccines, but there’s no evidence that one vaccine gives longer immunity and antibody protection than another. Thanks for your kind words!
Thanks! I found the journal paper the article referred to in "Cupovic, J., Ring, S.S., Onder, L. et al. Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8+ T cells. Nat Immunol (2021)". Here's the shareable link: rdcu.be/co5LS . Obviously, it is too technical for me!
Okay, let me repost: "Thanks for your wonderful content. My kids and I enjoy watching them! Recently, a friend forwarded me an article claiming that adenovirus vector based vaccines like AstraZeneca's can offer lifetime protection, unlike mRNA ones -> www.thesun.co.uk/news/15605950/astrazeneca-covid-vaccine-lifetime-protection/. I wonder if the news headline is exaggerating.....either way, it will be great if you can help us understand how this works."
@@chrisyong3536 Thanks for sharing! I’ll check it out. There are types of T cells that live for longer periods of time. Maybe there’s something to it. Nature is a very reputable scientific journal.
@@chrisyong3536, All the vaccines are the same and will offer lifetime immunity to Covid. People who developed antibodies to SARS-CoV-1 18 years ago still have antibodies today. Even when the antibodies reduce in number over time, the memory T-cells are still there remembering how to make them.
The problem is, when the antibodies are reduced in number, it’s because the memory T-cella are asleep, and it takes a while for them to wake up. In the time it takes for them to wake up, the virus is able to multiply and you can become contagious.
However, it takes only 2 or 3 days for the memory T-cells to wake up. If you are unvaccinated, it takes 2 to 3 weeks for your immune system to figure out how to make the antibodies. It’s this reduction from 2-3 weeks to 2-3 days that keeps you from getting really sick.
If you think they're safe, then please inject yourself weekly with a body-weight adjusted vaccine with merely the adjuvants (without the "active ingredients"). Body-weight adjusted based on how much people like you are having infants get injected with. I will pay you paid $100/dose to get each injection on camera.
Thank you for the excellent videos. Please excuse my greenhorn question: Around 21:50 you said there are sequences in the covid spike protein nobody knows what they are for. Does that apply only for the mRNA vaccine produced spike protein or also for the „natural“ covid spike protein?
Good question. Yes this is specific to mRNA vaccines. mRNA only lasts for minutes to hours, so it is likely that the researchers added some flanking sequences to the mRNA so it would last longer in your cells. This would not be the case for a vaccine like Novavax or Medicago which use a premade spike protein attached to a lipid/fat based nanoparticle.
Thank you so much for sharing your knowledge! This made me more comfortable about getting vaccinated.
Thank you! Let me know if you have any questions.
Amazing video! More slow science please.
Thanks so much! There will be two videos this upcoming week.
Thank you for sharing the mechanism, and it is super helpful! But the vaccine cannot prevent transmission. Will you update the mechanism after one year?
Hi, thank you for the video. It provides some relief that humans can still provide and get an understanding. Unlike the chaos that's happening around the world. I just have simple questions, if you don't mind, what is the natural mRNA's role in our body and how does the mRNA from the vaccine get discarded by our bodies. Also please if you can make a video about eczema. My son have it for 4 years now and it just keeps on coming back. Some Dr's says it's like fungus, some says, it's not about the immune system. Appreciate any reply from you. GOD BLESS!
Great examples and thank you for your video. I have a question and hopefully you can help me understand. With the vaccine with mrna, on the cdc page I thought it said that your body does not make antibodies. What does that mean? I want to understand how our body can get antibodies for the virus. I understand how important antibodies are. Please advise to help me understand a bit more.
Thank you for the great video. Sorry if this question is redundant. The buzz term going around about the MNRA’s is “Antibody dependent enhancement.” Is this a thing? Thanks again.
Thanks! I am actually going to do a video on Antibody dependent enhancement very soon. It is not a thing right now. There were vaccine trials in mice for SARS and MERS that had some feature of Antibody Dependent Enhancement 10 years ago, but those vaccines were made for a different protein. Researchers kept that in mind and made these vaccines for the spike protein which is a better target. Antibody dependent enhancement is more or less making a crappy antibody that accidentally allows the virus to enter immune cells like macrophages.
thank you so much, super informative. I'm still confused why some nurses are even refusing to get pfizer's, etc can you explain maybe in a mRNA vs Nanovax's the pros and cons of both ?
Our son's sister-in-law and her husband are both nurses and they both refuse the vaccines.
Amazing information. Could you make a video explaining how, why (or if) vitamins such as C, D3, or zinc suplemnts, or ginger, garlic etc are mentioned as boosters of the immune system? How would they work?
Thank you! I have a lot of subscriber videos in the queue, but I think that those are great ideas. I would probably do a video on Vitamin D first!
@@friendlyneighborhoodimmuno7192 Thank you so much, your work is amazing, it really educates and helps clearing up all the misinformation around. Have a great day
Actually I'd ask. About vitamin c as a IV. not as a supplement to fight covid as well as cancer.
As I've seen several doctors, virpogosgs and immologists speak out stating this simple treatment can cure cancer among other things through daily use for a certain amount of time.
Im a biologist and actually people have died from live attenuated virus vaccines, so they arent harmless in fact this is what led to the taking live attenuated virus vaccines from the market.
I showed this vid to my 13 year old niece Her goal is to study medicine (very smart cookie ). At the end. She put it back to the start and watched it again fascinated
Oh wow. You just made my day. Hope your niece gets to follow her dreams!
@@friendlyneighborhoodimmuno7192 Cheers. 🥃 She will Your vids must take a lot of work. Thanks for doing it. That are absolutely fantastic!!!!!!
Do have videos on how human adenoviral vector vaxx works like sputnik v?
Thank you greatly for a wonderful explaination! I live in Germany, and I got EBV Infection (Mono) around 4th of June. I still have my lymphnodes bigger then normal, but already have IgG in my blood. I am very worried, that if I will get a vaccine, I dont know how will EBV react to it. My doctor said to get vaccinated soon. If I dont, I will really be left out from social life, study, work etc.
Are there any links between these vaccines and any type of viruses (especially Herpes Virus) in the body.
Thank you very much, if you will ever have time to answer me!
With kindest regards
Thank you! Sorry to hear about EBV that can be rough. It's been two months so your T and B cells that were activated should have gone through their "die off" phase called contraction. It can take 1-4 weeks. I looked on Pubmed and I could not find a research paper that examines your specific situation. The first vaccine shot will likely not cause any issues for you. There is some inflammation after the second shot because your memory T and B cells get reactivated. I have a video on this if you are interested. It's tough. You may get some reactivation or you may not. On the other hand, getting COVID is considerably more inflammation and would be more likely to exacerbate the EBV. Whichever you choose, I wish you well.
@@friendlyneighborhoodimmuno7192 A great THANK YOU for such a wonderful answer. I contacted Biontech in Germany about my condition, but they answered that I and my doctor have to decide for ourselves, what we should do =) So they do not give any medical advice on my current situation. My EBV war pretty tough, I had a whole 10 days of fever, muscle pain, sore throat and extreme tired feeling in the body. Thats why Im pretty scared to have vaccine right now, because I heard that both vaccine and COVID give a reactivation of EBV...
@@vanessatool4346 Vanessa 10 Tage EBV ist nichts. Das ist eine Kurzzeitinfektion und nicht vergleichbar mit der wirklich schlimmeren chronischen Variante. Die Erstinfektion EBV in chronischer Form läuft über mehrere Wochen - wenn du Pech hast reaktiviert das Virus (wie bei mir) noch Jahre danach erneut und dann hast du richtig Probleme. Sobald die Viren überhand nehmen bist du chronisch krank (ich bin seit 3 jahren jetzt am Stück jeden Tag krank, jeden tag Schmerzen und weitere Symtome) dazu kommt das ME/CFS Krankheitsbild an dem die Charite in Berlin als mehr odet weniger einzige in DE forscht. Ich habe das. Es ist schlimmer als Krebs. Zwar nicht so tödlich - aber der Leidensdruck durch die Erkrankung ist schlimmer. Also kurzum unterschätzte das EBV nicht aber bewerte es auch nicht über, du hast mit 10 Tagen keine schlimme Infektion gehabt. Wenn du sonst fit bist würde ich an deiner Stelle die Impfung nehmen (ggf Valneva).
@@ABCstockholm007 Hi Ellei! Danke für deine offene Antwort. Ich hatte damals einfach Angst, dass es wirklich schlimmer wird. Wie kommt das, dass Person ein chronisches Verlauf hast? Ich habe, denke ich, akute Infektion, und jetzt keine M mehr, nur G. Ich habe 2Mal Pfizer im September/Oktober 2021 erhalten, danach in December war meine Blutabnahme nicht sehr gut (Leber war nicht ok). Jetzt ist besser. Ich überlege, ob ich mich mit Novavax impfen soll (3 Mal). Ich hoffe, dass die im Zukunft besser geht. Danke!
Really great, non partisan content, thankyou.
Would it be accurate to expect antibodies created from the mRNA vaccine to have the same efficacy as the antibodies generated through catching COVID?
Cheers from Australia.
Thank you for your kind words! Great question and not a lot of solid data. I would place this under the hypothesis category. Yes efficacy of antibodies should be the same from one vaccine shot as compared to surviving COVID. Now it's really the second shot that makes the vaccine antibodies superior in two aspects: 1) You will have more antibodies after a second vaccine 2) You will have more immune memory, specifically B and T cell memory. Cheers!
Awesome! Keep posting. Would love to see cancer next.
Thanks Seema! I will definitely do several drawing of cancer and immune system. Although there may be a few more COVID ones first.
Hi there could you please talk about the curevac vaccine. And the novavax and do either of these have Fetal stem cell lines involved in the development an do manufacturing of it.
I do have a video on Novavax. You can see it if you click on my channel. As far as I know, Novavax does not have any fetal cells in the vaccine or used in testing. I’m not familiar with Curevac, but I can look into it.
Can you do a segment explaining what goes on in our bodies when you have autoimmune diseases such as psoriasis, fibromyalgia, and endometriosis? Also why once you have one autoimmune disease you tend to develop other types as the disease progress?
Yes that is a fantastic video idea. I have a few other requests in the works, but I will do a video on this topic.
Are the abnormal immune dysfunction risk or the human turning against its self
Can you do a video on the medicago experimental injection in the future?
Yes! I can do a video on Medicago. It usually takes me a couple of weeks, but I'm teaching right now, so it might be longer.
Thank you so much for making this video!!
I just had a question- I hope I make sense:
Does the ribosome use only the mrna molecule to make the protein or does the ribosome add atoms from somewhere else to make the protein?
Is the only time a ribosome makes a undesirable protein is when it encounters the mrna from the vaccine?
Usually does a ribosome make a protein that is desirable for the body?
I guess I was concerned that since the ribosome is making a spike protein that it's like we are using our own body's atoms to build the spike protein? So we are using our own body's atoms (not something foriegn) to create the spike protein - could this be potentially problematic?
The ribosome uses the mRNA as the code only and adds your body's tRNA. Each tRNA has a protein attached. These proteins are natural in your cells and you can get them from your cells or your diet. The ribosomes make healthy normal proteins for your cells. For example if the mRNA is CCU then the tRNA that matches in GGA attached to it is the protein Proline. It should not be problematic when creating the spike protein. Good questions!
@@friendlyneighborhoodimmuno7192 thank you so much for answering my questions!! 😊
Thanks. I'd love for you to update this in light of current data, side effects, etc. Seems alot of this information isn't bring spoken about. Thanks.
It's best people don't know.
@@ex8280really? Is it better to believe the shots are sunshine and lollipops when the reality is they can provoke your immune system to attack the heart and maybe you should weigh the real risks before getting more of these things?
@@ex8280 most of the guinea pigs don’t WANT to know
Dude a snake with no fangs slithering around everywhere is BLOODY SCARY.
With love, Australia.
LOL
i wish the doctor who gave me the shot wouldve given me this explanation, instead of what i got, night and day difference
How does the blood P.H. Chemistry affect the overall effectiveness of these MRNA vaccines??
Sequences on either side of the mRNA spike protein, which none of us know what they're for. Isn't that just wonderful.
Most likely they are to extend the life of the mRNA for longer than 30 minutes.
How does the MRNA contained in PEG "just merge" with cells when SARS-COV-2 can't do that without connecting via an ACE2 receptor?
LNP's - emulsified cholesterol - were originally developed back in the 90's as a delivery mechanism for anti-cancer drugs to the cells. Your body is chock full of lipids such as cholesterols which help to make up the cellular membrane. So mixing mRNA with LNP's creates a microscopic mixture which is "permeable" to cellular membranes not unlike say sodium molecules can pass through into cells or things generated within the cells can pass through out into the circulatory system.
So "Pegylation" coats the LNP/mRNA molecule helping to extend its half-life + altering its charge + helping to mask it from innate immune response so as to be able to access the cells. If you want a detailed explanation of the process read the article _"Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery."_
Can you look into whether its of some fact, in regards to comments by other Doctors in this field that with these particular mrna vaccines, the antibodies produced bully the other antibodies so as then to let the potential of other variants or viruses through to infection.
Sure I can check it out, but I try to use sources from Pubmed as often as I can. This is a website that only has peer-reviewed scientific publications with data. As far as I know, there is no published data demonstrating that mRNA antibodies will bully other antibodies. This is a very very uncommon phenomenon. Some people have ideas that this is happening, but I have not seen any data to prove it. I'll research and let you know.
How quickly does the PEG disintegrate? Is it possibly dangerous being injected and absorbed into our capillaries?
Thank you for the information, it has comforted me. I am terrified of the new mRNA vaccines.
With reason . Listen to that
You mention "its one code for one part of the virus" - could this give a gap of knowledge where the variants come from or as to why it isnt as effective with the new variants?
Also with the PEG I've heard it is the reason there are adverse reactions?
Also as you mentioned after 24 hours there wouldnt be any mrna spike protein in your body. Would it be possible that you could be infectious to other before 1-24 hours after the v@x?
Save it 😊
Very nice, but those spikes hang around for a while, don't they?
no one likes discussing the Japanese Pfizer Biodistribution study published in the spring of 2021
Could you make a video explaining the gene therapy action, how the mrna activates the dna?
It doesn’t. DNA is in the nucleus and mRNA doesn’t go inside the nucleus. It doesn’t interact with DNA, at all. This is not gene therapy.
Key word here : code !
The mRNA molecule might only last 30 minutes but not so the problems caused by the protein spikes, ie long Covid. If I would have had your video about how the mRNA vaccines work it would have saved me hours of research, thank you. I already have watched your cancer video and it was also great, just like this video. I am going to look at all your other videos and look forward to them.
Thank you so much!
Excellent video, makes me feel more comfortable about the vaccine. Just one question… when the mRNA comes into the cell, you said it gets broken down quickly, then you mentioned the cells stomach where the Covid protein is broken down… is the mRNA information broken down into the Covid protein? Where did the protein come from? As you said the vaccine doesn’t have any Covid in it just information…
Thank you!
Ok let me try and clarify. The mRNA contains a code that gets turned into a protein, but your body makes the protein the same way it makes all of your proteins. You have a process called translation in all of your cells. Crash course on TH-cam has a great video about translation if you are interested. mRNA has to find something in your cell called a ribosome and it builds a protein based off of the code on the mRNA. For example, if the mRNA code was UGU CUA then two building blocks of a protein would be added together. Does that help?
I don't know if you'll ever see my question, but asking just in case. You said that mRNA get into ANY cell. Then ANY cell can produce the protein. You described what happened inside macrophage, but what happens in another cells when proteins are produced there?
Great question. Yes those regular tissue cells can make the spike protein too. It’s likely just for 48-72 hours based on bio distribution data. Then the mRNA gets degraded. By the time the immune cells like B and T cells get activated (7-14 days) the tissue cells will be done making the spike proteins. It might cause a rare issue in some people, but according to the CDC it’s safe in 99.9% of people.
Very nice presentation. You mention that the nano-particles containing the spike mRNA are potentially picked up by any cells in the body, not just the antigen-presenting cells in the soft tissue at the injection site. So ordinary cells in other organs (including the brain?) will express spike proteins on the cell surface. Will they not then be attacked by the cytotoxic T cells sensitized to the spike protein through vaccination? Risk för autoimmune diseases?
finally someone with a brain.
seems obvious, but no, it's safe and effective.
I'm in California. I want to get the Novavax vaccine. Any idea where I can get it?
Same as me
It’s not available yet. They’re hoping November I think?
I love mRNA technology, it looks very promising for other applications too, like cancer treatment
Yeah there are a lot of possibilities to treat cancer and rare genetic diseases.
Though I'm not taking the mRNA vaccine thanks for vid
Thank you! It's good to know your options and what is best for you.
Hi i am from Bangladesh. I was affected Covid 19 on august 2020. That time my platelet level was 400k. But last one year platelet level down chronologicaly. Recently do. Doctor examine my bone marrow and said i am ITP patients. Doctor prescribed me prednisolone ( steroid) tablet and some vitamins. But i am suffering from severe weakne can’t maintain normal life and can’t continue my office. What can i do? How i manage itp? How i increase my immune system? Am i able to back in normal life? Have any treatment?
My present platelet level 100k
What about the whistle blower video that reveals the use of graphene Oxide in the Astra Zenica vaccine?
I have not seen that. When I Googled it I got an ageism lawsuit. Can you try to send the link? TH-cam does delete posts with links sometimes.
There's alot of mixed debate about aspirating needles when giving vaccines to ensure they are being injected correctly, what would happen if instead of your muscle cells this vaccine ended up elsewhere?
It would be absorbed wherever it was injected, and the rest would be eaten by immune cells and then broken down in the liver or spleen.
@@friendlyneighborhoodimmuno7192 thanks. I have some hyper-concerns around the mRNA vaccines. Backstory is I lost my son a few years ago to orai1 deficiency or CRAC channelopathy I've seen it listed as since so that started my solo learning about how the body does it's thing, have 4 other kids and 2 are going to be required to get vaccinated. Finding answers to anything the last 18mths is not as easy as it was pre-pandemic and trying to find the science amongst the politics and conspiracies is even harder, specifically what Nikolai Petrovsky mentions in this at 52mins th-cam.com/video/yL_2Rq1zoRg/w-d-xo.html when also taking into account the minimising of the innate system to maximize the vaccines start up in the body. We've had a huge Pfizer push in Australia 🙁
Good content. Teeny tiny illustrations and writing is impossible for me to read.
Sooo... what is the one you have taken?
Last July I volunteered for the phase III clinical trial in my area. I received the placebo in August and then got unblinded in February of 2021 and received two shots of the Pfizer vaccine.
Great video tons of thanks. But the vaccine fat bubbles enter all cells. Not only the "eaters". Will the other cells also put spikes on their surface. If yes, then wont those other cells be a target of the antibodies and the immune system? These questions are what stopping me from taking these mrna vaccines.
That's a very good point. Yes the fat bubbles can enter any cells and make spike proteins. The timing of everything is very important. I just read the Pfizer Biodistrubution data. I have a video on it if you are interested. It seems like the mRNA is mostly gone by 72 hours and very minimal by day 9. It should take your immune system two weeks to make the B cell antibodies. So there shouldn't be overlap with your non-immune cells making the protein and your B cell antibody production. But it is an understandable concern, and it seems like in the majority of people (but not all) that this timing is not an issue. It could potentially explain some clotting issues though. Although they are rare in the Pfizer and Moderna vaccines.
@@friendlyneighborhoodimmuno7192 Yes i am interested in the Video please. Much obliged for your response. I can feel that you are sincere in what you do. I will have more questions once I watch the Video if that is OK.
I believe the technology of mRNA is amazing & exciting. Also love the videos!
So I understand now from your video the nanoparticle containing the mRNA can attach to ANY cell (like the macrophage in your drawing)
However what happens when the mRNA attaches to a MUSCLE CELL. In most reputable public documentation (from CDC etc) it states that the mRNA instructs our muscle cells (not any cells) to manufacture the spike protein itself, where it is displayed on the outside of the cell & then dealt with in the immune response.
Does the macrophage then recognise the muscle cell as foreign, consume & destroy it, & then continue the immune response by going to the lymph nodes etc? And then our own cell becomes foreign & is destroyed. I also understand that there is a finite amount of mRNA nanoparticles injected, so because of their short life span they have that one chance to bind to a cell or not. And thats the end of them.
Also, if the injection has very little else contents, why are there concerns for the unknown long term effects even though after the nanoparticles are destryoed after their short term process. What sort of issues can happen down the track?
Good questions. I think the CDC says the mRNA is in the muscle cells because about 83% of the lipid nanoparticle stay in the muscle in rodent studies. Yes the muscle cells can make the spike protein, but the macrophages will not target or attack your own muscle cells. The macrophages just follow their programing to target bacteria, viruses, and fungi. However, the B cells and T cells could target cells that have spike protein. But like you said there is a finite amount of mRNA with a limited lifespan. By the time the B cells and T cells recognize the spike protein (10-14 days) the spike protein is no longer on the outside of your muscle cells. I think that the main concern for long-term effects is that something off-target or unexpected could happen.
This is very informative,
Still no medical procedure must be impose to a human . RNA or not, nanobots or not, free choice . Is the way how every government with the same script was imposing the drug that literally made be to stay away from it and anything to do with this c19. 🤗
When a cell uptakes the mRNA to produce the protein spikes those are carried outside the cell where they can manifest upon the cellular membrane and into the circulatory system when they encounter your immunoglobulins. Similarly when a virus invades a cell it leaves those same markers on the cell membrane akin to keys to a lock. Antigenic proteins used by a virus to attach to a cell only fit membrane receptors which match up to the morphology of the protein.
This is why certain viruses cause specific side effects as that indicates what systems the virus can infect - such as respiratory cells etc.. The Covid virus spike proteins however have a high affinity for ACE2 receptors which are ubiquitous in the body - especially the cardiac/vascular systems.
So as alluded to the B/T-Cells upon being activated to recognize that specific structure perform their tasks. B-Cells will "mature" to generate IgG specific antibodies which mirror the antigen structure. That way if a virus with those spikes are encountered the antibodies can glom onto the antigen binding sites to block them. A virus with its binding sites blocked can not attach and replicate itself. Then other immune cells - macrophages - drawn to the inactivated virus will envelope and destroy it.
The T-Cells on the other hand will upon encountering "abnormal" cells which "present" the protein spikes on the membrane can trigger cell destruction via cellular apoptosis. The destroyed cells are then replaced with normal ones. This all happens with any viral infection not unlike with what the vaccine does - save for the vaccine only introduces the segment of mRNA to generate one part of the virus rather than a complete version of it = protein spikes.
Finally side effects. Look at the rare serious side effects susceptible people manifest following vaccination. See whereby they usually occur = within a week or two of inoculation. So the immunological reaction to an infective agent will not typically last long. Within a few days your immune system is activated - and within a few weeks it has usually resolved the exposure. It can take years to approve vaccines because it takes time to run the various clinical trials etc. as opposed to looking for side effects per se. What side effects following vaccination are typically seen fair quickly.
(Only just seen the video - very informative and appreciated!, but:) I don't follow this answer fully. If you've already had the disease, or are going for a booster vaccine, surely you have some immunity to the spike in situ, so the 10-14 day safe window post-vax would not apply.@@friendlyneighborhoodimmuno7192
What affect does the covid vaccine have on those with autoimmune disease or disorders ? I wonder if there have been any studies done. Thank you for your video.
If they leave the body in a maximum fo 24 hrs, what possible long term effects are we talking about? Anything serious that will make me regret getting the vaccine? Thanks !
I personally got the mRNA vaccine back in February with some fever and muscle aches after the second shot. I don’t personally know anyone who has had any adverse effects, but a few commenters have mentioned people they know (typically older) who have had adverse reactions. The CDC keeps track of adverse effects and right now the mRNA vaccines have been safe in 99.9% of people. You can check the CDC website. Sometimes TH-cam pulls my comments if I add a link!
@@friendlyneighborhoodimmuno7192 thanks! I love all your videos, they’re so interesting and well explained 👌🏻
Would love to know the difference between Pfizer and Novavax.
Pfizer is an mRNA vaccine with the code for the spike protein. In that vaccine your cells make the spike protein. In Novavax, the spike protein was made by moth cells. In the shot, there is only spike protein attached to lipid nanoparticles.
Does each mRNA make one protein, or several proteins? And approximately how many mRNA molecules are in the mRNA vaccines? In other words, how many spike proteins will we produce when we are vaccinated, and how does that compare to the spike proteins produced by someone who is infected by SARS-CoV-2?
Also, what happens to those spike proteins? Do they leave the cells and float around? Can they enter the blood stream?
Each mRNA molecule can make dozens to hundreds of proteins per molecule. They last between 30 minutes and 24 hours. I do not know how many mRNA molecules are in the vaccine. Some people make detectable spike protein in their bloodstream for 19 days, but the average is 5 days.
@@friendlyneighborhoodimmuno7192, “Some people …”
They should conduct a study to see exactly how many, and whether there’s any correlation between spike proteins in the blood and severe adverse reactions. They could also monitor the immune response and see if that’s in any way related. My guess is that the stronger the immune response, the more the adverse reactions and likely a lower dose would have been better for those people.
I believe they should half the dose to reduce side effects, but that would likely also reduce the efficacy in those who need the larger dose. But fewer adverse reactions might get more people vaccinated, so it’s a tradeoff.
@@friendlyneighborhoodimmuno7192 So basically, one of the main advantage of mRNA vaccins over the older ones is that it use the mRNA and ribosomes as an echo chamber in order to boost the antigenic charge (spike prot). Right?
Correct!
@@titouchose6534, The results of what you just said is that we need a smaller dose of mRNA than we need of previous vaccines. Less active ingredient means more doses with less manufacturing. So they can make more doses faster.
They don’t want to give us 10x more spike proteins, because that would be too much, so they give is 1/10th as many mRNA. (Assuming a 10x boost)
Looks like the spike proteins are turning up in different organs and lasting way longer than the time period we were originally told..
...........and. 🥱
p.s. - your body is chock full of proteins of all kinds. Proteins can not self-replicate either. So the mRNA vaccines generate segments of proteins which per their morphology can upon release back into the bloodstream attach to ACE2 receptors found everywhere in the body - the same as the Covid virus coincidentally.
As with all proteins they will eventually break down or upon being encountered by circulatory immunoglobulins be cleansed from the bloodstream. So if you had a point to make = you failed to make it.......
@@varyolla435 1)This is a good point, but if this is the case, why would your body create anti-bodies for them when they encounter the covid virus/vaccine if it's harmless?
2. hmmm...this is probably true, if your first assumption is correct, but if there is an abundant of sprike protein in the blood stream, the immunoglobulins might choke the bloodstream causing blood clots and other issues related to blood restriction in the body such as heart attacks and strokes. But it all depends oh how much spike protein is in your body, and if it congregates in specific areas such as an organ, you might be in trouble if there is too much. This is why when people heard it doesn't just stay at the injection site, people began to worry.
@@ex8280 1 - the "protein spikes" created as a result of introduction of the vaccine to the cells = mimic those found on the surface of the Covid virus - which it uses to attach to cells so as to replicate. Antibodies are formed as a result of the "antigenic" structures found on the surface of a pathogen which your immunoglobulins recognize as not belonging. Hence antibodies are generated based upon = shape of these antigen structures.
2 - blood clots form as a result of an inflammatory process = which is the crux of an immunological reaction. So people infected with actual Covid who are hospitalized also manifest clotting problems = save for more often and more severe than what is seen with the occasional adverse vaccine reaction.
3 - the amount of mRNA in a vaccine is finite and of limited duration. So cells only produce protein spikes commensurate with the amount of mRNA available = while that mRNA will break down in time. So a cell which uptakes mRNA from a vaccine will not forever more produce protein spikes. The mRNA strands are disassembled as they are "read" and corresponding protein spikes are assembled.
At some point the process will cease while cells manifesting those spikes on their membrane will be targeted for destruction per cellular apoptosis.
I don't know if you would be interested, but, I would love to see a video about Autoimmune Encephalitis. So little is known and mentioned about this disease. I contracted it 6 yrs. ago and have been hospitalized twice with seizures from it. It is a scary disease. No known cause, no cure. Thanks for your consideration.
I’m so sorry to hear that. Yes I can absolutely do a video on that. I take requests. There’s a few requested videos in the queue, so maybe two weeks. I teach autoimmune diseases in my upper level class. Take care!
@@friendlyneighborhoodimmuno7192 Thank you so very much. I have had this for 6 yrs., and still don't understand it.
I'm really glad I didn't have to get an mRNA vaccine.
we lucked out. A lot of people didnt have a choice, or didn't have the courage to say no.
No thanks keep them
Actually I'd ask. About vitamin c as a IV. not as a supplement to fight covid as well as cancer.
As I've seen several doctors, virpogosgs and immologists speak out stating this simple treatment can cure cancer among other things through daily use for a certain amount of time.
Great info. but I will not take this until it has been out for several years and it is clear that there are no long term effects.
Translation: _"I have no understanding and are therefore being consumed by my paranoia and assumptions."_
Where were you in college lol!! NO teacher in my college prep school and all those AP/IB classes could explain anything so we could understand lol. Well, it was in the 1990's. No you tube, nothing but books haah
LOL! I went to a large state school in Texas. I had a few gem's of wonderful teachers and professors. There really is content for almost anything on TH-cam.
My complements to your teachings. I am a bit hesitent to taking the pfiser vaccine,leaning more towards the nova vax but in my country I can only take the pfiser, have no other choice. Face loosing my job,loose freedoms regarding the vaccine passport,not even talking about bolieing at work by co workers and having to deal with long covid if I do get infected. I am concerned about the metal,graffiene being used in the pfiser vax and it affects on the body. Some scientists have pointed out the dangers about the pfiser vax and nobody who promotes the pfiser vax talks about the grafiene, and its purpouse.I have seen pictures of blood work after pfiser vax and it does not look good it thikens the blood. Also dark spots, most likely the grafiene, is also detected. I have to make a choice and need answers. Can you please assist about the role and dangers of grafiene?
Hi! There is no graphene in the Pfizer vaccines. The Pfizer vaccine have a lipid/fat based nanoparticle. The graphene is water based, so you cannot really even mix the two. Hope that helps.
@@friendlyneighborhoodimmuno7192 Thanks for your reply. If I get the pfizer shot. Does my body start making the spike proteien. Will it be present in my blood. Will there be even more of that after the second dose?
@@janfourie209 yes some of your muscle cells will make the spike protein for 24-72 hours. You will make the same amount when you get the second shot, but you will make more antibodies and immune cells like memory B and T cells.
Aged pretty well… 🥴
Just wondering why people that have been fully vaccinated are catching covid and can pass it to others?
The breakthrough infections of vaccinated people are only around 1-2% of vaccinated people, so 98% of vaccinated people are not catching Covid and passing it to others. The reason a few percentage of people who are vaccinated are getting Covid is likely because they did not make high levels of antibodies to start or they were vaccinated over a year ago and their antibody levels have started to drop.
Splenectomy
Very interesting. I have a question, how does the vaccine affect our DNA? Does it erase our DNA like some are saying.
but a normal tissue cell does not go to the lymph knotes as the macrophage does, does it ?
do you mean that if vaccined, i get flooded with covid19 antigenes for about 6 - 24 month ?
Isnt this a state of illness ? Can this antigenes fight other deseases ?
Can the immunesystem fight other deseases meanwhile ?
Could you please explain how our immunesystem works when infected with covid19 ?
Where are the limits of our immunesystem ?
Only immune cells traffic from tissue into lymph nodes. This includes macrophages and dendritic cells. I have a video on how long the mRNA hangs around in animal models. It's the Biodistribution of Lipid Nanoparticles video. In animal models the mRNA peaks at 6-24 hours and is hard to detect at 72 hours. However, the spike protein might be in your body for days afterwards, but not months. The immune system can fight other disease at the same time as the vaccine. It is difficult but possible for your immune system to fight other infections when you get the actual COVID virus.
@@friendlyneighborhoodimmuno7192 Is it true that the regular tissue cells will receive the MRNA instructions as well, reproduce the Covid spike protein, and put them out on the surface, thus making those cells a target of the immune system including the eaters cell? Do we know that our immune response will not hurt any part of our tissue cells and affect certain functions negatively?
Great video, however there is a lot more to the robot than its foot. It's like trying to tell what computer you have by its keyboard. I still contend that the whole virus is a better ID. Why limit yourself to just one part of the virus?
That's a great question. There are whole inactivated vaccines available from China (Sinovac), India (Covaxin), and France (Valneva). The reason for choosing the spike protein is because it is the key to enter our cells. As long as you disable the key, the virus cannot enter our cells. The spike protein is the best target for preventing entry into our cells. Having said that, a variety of antibodies is usually best.
this is how u would explain to a 10 yo. seriously.
The scratching of the marker pen is distracting, great video otherwise
Thanks for letting me know! I will make some videos with minimal scratching!
I've heard so many people say such terrible things about the vaccines. I've gotten the pfizer, but still afraid of long term effects. I've heard the spike protein can cause the immune system to attack itself and compromise the immune system, cause misscariage etc. Is this true???
What happens if the vaccine enters the nucleus?
Too many unknowns.
It can't. For mRNA to be able to enter a cell nucleus - as opposed to mRNA generated by the cell which exits the nucleus - it would require an enzyme = reverse transcriptase. This is not present in the mRNA vaccine sequence and thus the nucleus is impermeable to it.
The vaccine mRNA is acted upon by the ribosomes in the rough endoplasmic reticulum the same as if the virus invaded the cell. Meanwhile the Covid virus is not a "retrovirus" = meaning a specific group of viruses which have the reverse transcriptase enzymes so as to be able to infect cell nuclei.
@@varyolla435 ‘REEEEEEE, REEEEEEEE, REEEEEEEE’
😂🤣😂🤦🏽♂️🥴🤡
They have sent moving pictures with sound and color through the air for almost 100 years now , why can't they send some signals to your cells to do something. All they needed was to insert a receiver in these cells.....Now you know why when they draw spike protein it looks like satellite dishes. I love my injection, now how to communicate with all my cells, I'm going to DM them soon!