Why do allergies happen? | Immune cells and allergy

Allergies happen because the immune system accidentally recognizes harmless things like food as if they were something dangerous like a virus. Then immune cells like macrophages take a small piece of the allergen to a T cell which activates B cells. B cells make antibodies that mast cells grab and wear. When this happens mast cells can quickly bind to the allergen and release histamine which causes running nose, watery eyes, tight throats, and hives.

[@jazzmaq]

Now I understand, why my second alergic reaction to penicillin was much worse, than the first one. I wish I could have a teacher like you, when I was in school :)

[@nope.itsjustmoi3169]

Does this mean that after a maximum of 20-30 years and ideally you never encounter the first allergen again during that time period, your B cells will die out and you can eat those foods again (assuming you are not in a state of inflammation)?

[@UHFStation1]

What causes eczema? And why does inflammation from it relate to contact with foods or allergens?

[@vinothshivaraj4318]

Hoping for a solution from you and thy fraternity.

[@UHFStation1]

Haven't they found that microdosing with peanut can build a tolerance?

[@vinothshivaraj4318]

Hello, recently I came across a video about a doctor named Dr. Shankara chetty who treated more than 4000 covid patients with zero mortality with promethazine, Prednisone. Promethazine or any H1 or H2 inhibitors hold any promise against covid19? Or the hypersensitivity (according to Dr. Chetty)..any opinion is highly valued, thank you in advance.

[@friendlyneighborhoodimmuno7192]

This is an interesting and complicated question. I think it depends on who the patients are. I would not necessarily think most people with COVID would need this treatment. However, people with severe COVID symptoms or those experiencing excessive inflammation or "cytokine storm" could likely benefit from this combination treatment. Several large research studies have shown blocking histamine helps dampen the immune response, but blocking histamine does not stop the virus at all. In some people with excess inflammation this could make sense. I always recommend asking your personal doctor before making any medical decisions. If you are interested here are the research papers I found! www.ncbi.nlm.nih.gov/pmc/articles/PMC7673069/#:~:text=Three%20histamine%20receptor%20antagonists%20were,common%20symptoms%20of%20COVID%2D19.
www.candi.nhs.uk/sites/default/files/COVID-19%20and%20Benzodiazepines%20-%20CI.pdf

[@vinothshivaraj4318]

@@friendlyneighborhoodimmuno7192 Thank you so much for thy timely reply. I am neither a doctor nor an expert. Our physicians are working tirelessly in fighing covid. The numbers are soaring, thought if I could bridge experts like you with those doctors in our rural areas, they might consider the possibility of using such drugs with patients to ease their pain and hence the question. meanhile as a layman I try reading and learning as much as I could about covid and immune response. Thank you once again for the timely response.

[@vinothshivaraj4318]

@@friendlyneighborhoodimmuno7192 forgot to add another question of mine. I've been digging thorough archives and also from WHO protocols and found PVP-1 Nasal spray/solution worked better agains MERS, can the same be true against covid? Some recent articles suggest it's much more efficient than any other alternatives.

[@friendlyneighborhoodimmuno7192]

@@vinothshivaraj4318 You are asking a lot of intelligent questions for someone who is not an expert. It is admirable that you are thinking about people in rural areas who need our help. It seems like yes the PVP-1 Nasal spray is potentially effective against SARS which includes COVID19. In fact there is an clinical trial at Stanford examining this nasal spray. clinicaltrials.gov/ct2/show/NCT04347954
link.springer.com/article/10.1007/s12070-021-02525-9
This does seem like a safe and effective treatment as far as I can tell. Is there a good charity to donate to? Is Care India a good place to donate? Take care

[@terjeoseberg990]

So don’t eat when you’re sick?

[@friendlyneighborhoodimmuno7192]

Lol I suppose that would work to some degree. Most of these allergy responses get stopped by tolerance. I’ll have to do a video on that later. If the co-stim isn’t present and MHC binds then the T cell becomes inactivated. So ideally most T cells for unhelpful things get inactivated.

[@dannythemedic]

ughhh the generic injector!!!!!