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- 801 894
Friendly Neighborhood Immunologist
United States
เข้าร่วมเมื่อ 14 ม.ค. 2021
Hi it's your friendly neighborhood Immunologist! I've had my PhD in Microbiology and Immunology for about 10 years, and I'm here to empower you with knowledge of how the immune system works. Are you concerned about the new COVID vaccine and want to know how mRNA vaccines work? Do you want to know how allergies start and why allergy shots help? Would you like to know how the immune system fights cancer? Well I'm here to break it down for you in great detail one colored pencil drawing and bad joke at a time.
Guillain barre | Molecular mimicry
Guillain barre is the main cause of short-term muscle weakness or the short-term inability to move your muscles. It is primarily caused by the bacteria Campylobacter jenjuni which is found in undercooked, infected chicken. One to three weeks after your immune system fights off the infection, the immune cells begin to target the nerves. This is due to molecular mimicry. The bacteria has a protein that looks almost exactly like the coating of your nerves. Therefore, the B cells, T cells, and macrophages begin to destroy the myelin coating around nerves and even destroy nerves themselves. Nerve destruction leads to the inability to move. Removing the antibodies that the B cells make seem to improve Guillain barre in 80% of people affected. The antibodies are removed through plasmapheresis (similar to dialysis). .
Sources:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3755430/
www.cdc.gov/campylobacter/guillain-barre.html#:~:text=Infection%20with%20Campylobacter%20jejuni%2C%20which,the%20United%20States%20gets%20GBS.
Sources:
www.ncbi.nlm.nih.gov/pmc/articles/PMC3755430/
www.cdc.gov/campylobacter/guillain-barre.html#:~:text=Infection%20with%20Campylobacter%20jejuni%2C%20which,the%20United%20States%20gets%20GBS.
มุมมอง: 2 552
วีดีโอ
How does Lyme Disease Happen?
มุมมอง 852ปีที่แล้ว
Lyme disease is caused by black legged ticks also known as deer ticks. Lyme disease happens because ticks drink bacteria-infected blood from deer and mice in the wild. The deer and mice have Borrelia bacteria in their system which transfers to the ticks. Then when the ticks bite humans, the ticks transfer the bacteria to people. If caught quickly and treated with antibiotics, Lyme Disease can b...
T cells | Immunology Lecture | MHC-I versus MHC-II
มุมมอง 4Kปีที่แล้ว
This lecture is about T cells and major-histocompatibility complex I and II (MHC-I and MHC-II). The video will go over how T cells and antigen presenting cells fit together and activate. We will discuss where proteins come from to load into MHC-I (the cytosol) and MHC-II (vesicles). Furthermore, I will discuss the differences between CD4 and CD8 T cells. We will also cover positive and negative...
Immunology Lecture 5 | Pathogens and the immune response
มุมมอง 2.8Kปีที่แล้ว
Immunology lecture 5 is about pathogens and the immune response. Specifically the life cycles of bacteria, the Gram-stain, life cycles of RNA and DNA viruses. Then we will talk about which parts of the viruses and bacteria bind to toll-like receptors. Lastly we will cover other innate immune mechanisms of killing pathogens including reactive oxygen species such as superoxide and hydrogen peroxi...
Immunology Lecture 4 | Cytokines and Chemokines | Toll like receptor signaling NFkB
มุมมอง 10Kปีที่แล้ว
This lecture is about cytokines and chemokines as well as the toll-like receptor pathway. We will focus on Myd88 and NFkB and how toll-like receptor engagement causes most innate immune cell inflammation. The second half of the lecture will be about individual cytokines such as IL-1, IL-6 and TNF-a.
Immunology Lecture 3 | Innate immune cells | Leukocyte rolling adhesion
มุมมอง 3.8Kปีที่แล้ว
This is immunology lecture 3. We will cover innate immune cells including macrophages, neutrophils, basophils, and natural killer cells. Importantly, we will also cover how immune cells leave the blood stream and enter tissue, a process called leukocyte rolling adhesion. Here's a link to my favorite video about real immune cells during leukocyte rolling adhesion. th-cam.com/video/Ys6RlglMTMg/w-...
Immunology Lecture 2 | Primary and Secondary Lymphoid Organs and Blood (Hematopoiesis)
มุมมอง 7Kปีที่แล้ว
Immunology lecture 2 will cover both the primary and secondary lymphoid organs and the components of blood. We will briefly cover innate and adaptive immune cells, as well as granular versus agranular cells. Additionally, you will find information about hematopoiesis.
Immunology Lecture 1 | Brief History of Immunology
มุมมอง 16Kปีที่แล้ว
Welcome to my immunology lecture series! There will be 10 lectures about immunology. The first lecture will be a brief history of Immunology, including the discovery of the microscope, the smallpox vaccine, the cholera vaccine, and the polio vaccine. Additionally, we will talk about the discovery of antibodies and passive versus active immunity. The remaining lectures will be about Neuroimmunol...
Prion Disease | How does Prion Disease Happen
มุมมอง 118K2 ปีที่แล้ว
Prion Disease is caused by a single protein that makes a mistake and misfolds. If you want to know how Prion Disease happens then this video is for you. I will go over the top 3 most likely ways a person can get Prion Disease, what Prion proteins do in the body, and the role of the immune system in Prion Disease. Here are my sources: www.hopkinsmedicine.org/health/conditions-and-diseases/prion-...
Vitamin D and the Immune system
มุมมอง 29K3 ปีที่แล้ว
Vitamin D and the immune system work together. You might be surprised that vitamin D can boost and suppress the immune system. Vitamin D can boost primitive defenses of macrophages (Cathlecidin, LL-37, and Beta Defensins. However it reduces classic inflammatory cytokines like IL-1beta, Il-6, and TNF-a. Vitamin D also suppresses the adaptive immune system, B and T cells. This means that high lev...
ADE | What is Antibody Dependent Enhancement
มุมมอง 18K3 ปีที่แล้ว
Many people are wondering what is Antibody Dependent Enhancement or ADE. Antibody Dependent Enhancement (ADE) is a second key for a virus to enter your immune cells. Viruses have spike proteins that allow it to enter one or two types of cells like lung cells or neurons. That is the first key. If antibodies bind to a virus in a non-neutralizing way, the virus can enter immune cells called macrop...
How scientific papers are published
มุมมอง 1.8K3 ปีที่แล้ว
You might be wondering how scientific papers are published. I have published 12 scientific papers, and I can tell you the 7 steps need to publish a scientific paper. I have been accepted and rejected from scientific journals, and I will even show you my reviewer comments from two of my accepted papers. The review of research by other researchers is called peer-review. One peer reviewer is kind ...
A little bit about me
มุมมอง 4.1K3 ปีที่แล้ว
Hi! This is a video about my background, education, a few personal things. Hope it's interesting and helpful. B.S. Microbiology 2006 Ph.D Microbiology 2007-2012 - Studying T cells, microglia and bacteria Post-doctoral research 2012-2016 - Studying Alzheimer's disease and microglia Visiting Assistant Professor 2016-2021
APOE2 | APOE2 Longevity and Alzheimer's Disease
มุมมอง 6K3 ปีที่แล้ว
APOE2 is an important protein in the brain. APOE2 has been found to increase longevity in people as well as animals. APOE2 has been found to reduce the risk of Alzheimer's disease. The video is a requested video about doing a deep dive into APOE2. Overall, APOE2 reduces total cholesterol and increases activity which could be why people with APOE2 live longer on average. Review Paper APOE2: mole...
Natural Killer cells | Top 5 ways Natural Killer cells work
มุมมอง 39K3 ปีที่แล้ว
Natural killer cells are unique immune cells that kill virus infected and cancer cells. In this video, I will draw the top 5 ways Natural Killer cells work for you. Natural Killer cells are related to B cells and T cells, and interact with your "name tag," the MHC-I receptor that is on all of your cells except your red blood cells. The Natural Killer cell will spare any cell with your name tag,...
Autoimmune Encephalitis | What is Autoimmune Encephalitis
มุมมอง 29K3 ปีที่แล้ว
Autoimmune Encephalitis | What is Autoimmune Encephalitis
T cell memory | CD4 and CD8 T cell memory
มุมมอง 43K3 ปีที่แล้ว
T cell memory | CD4 and CD8 T cell memory
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
มุมมอง 6K3 ปีที่แล้ว
Alzheimer's drug Aduhelm explained | Aducanumab and Alzheimer's disease #Aduhelm
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
มุมมอง 24K3 ปีที่แล้ว
Alzheimer's disease and amyloid beta | Immune system and amyloid beta
How do allergy shots work? | Th2 cells and IgE
มุมมอง 20K3 ปีที่แล้ว
How do allergy shots work? | Th2 cells and IgE
Why do allergies happen? | Immune cells and allergy
มุมมอง 6K3 ปีที่แล้ว
Why do allergies happen? | Immune cells and allergy
How does the immune system fight Cancer
มุมมอง 21K3 ปีที่แล้ว
How does the immune system fight Cancer
How does thrombocytopenia happen | Low platelets and the COVID vaccine
มุมมอง 28K3 ปีที่แล้ว
How does thrombocytopenia happen | Low platelets and the COVID vaccine
COVID Vaccine side effects are Good! *Mostly
มุมมอง 2K3 ปีที่แล้ว
COVID Vaccine side effects are Good! *Mostly
Don't take Tylenol before COVID mRNA vaccine
มุมมอง 3.6K3 ปีที่แล้ว
Don't take Tylenol before COVID mRNA vaccine
perfect explanation
Do you believe we will see an increase 10-20 yrs from now due to the increase of mRNA?
Hello, I'm a teacher, immunology teacher! you are great and fascinating, I learnt many thigs from you. I advise my students to use your videos. Your background is very interesting and amazing, thank you for all. Hossein, MD, PhD
Great video u taught really well with full patience and love makes the lecture more interesting ❤❤
Outright perfect dissertation. Patiently narrated and excellent visual drawings. Your videos should be in all educational institutions. I hope we began to do more research on histidine and carnosine, as they are so unbelievably important in so many diseases.
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Excellent discussion!
Fantastic video! Thanks!!
Is there a certain point where removing the lymph nodes and using stem cell therapy to reestablish healthy cells would be too late?
Can you do a video on Herpes encephalitis and about the spinal cord, tests and treatments please?
Isn't pfizer working on vaccine, already in phase III, hopefully ready for 2026?
1) this was a fantastic video, cogent & thorough. Subscribed! 2) if there are 3 ways to spread dysfunctional prions, then cannibalism (BSE or Kuru) involving the consumption (of the spinal cord or brain) seems to be the "on steroids -mega-super-effective" way to 'best' facilitate the transmission of ANY bad/rogue/defective prions (to unaffected individuals), no matter which of the 3 ways they were created. 3) when an infected dendritic cell dies, does this always result in the spread of extracellular PrP-sc to other dendritic cells, or is there any way this chain of infection can be stopped? 4) my roommate and I, as non-militant vegetarians, had great hopes that vCJD would take out a few billion, but no such luck. Ebola let us down, along with numerous other disappointments involving the quick and easy dispatch of unproductive homosapiens. As a statistician, the 'unspecified virus of unknown origin' was clearly a non-starter, because right from the first batch of information, the lethality without the presence of the multiple other co-factors was tiny.
I learned that with HIV virus packs his bags and moves in a healthy cell and bind and becomes the Exact replication of a healthy cell. Can killer cells even spot those unhealthy cells as well?
Nevermind you covered it 😂😂😂❤️ in number 4 killing the dna 🧬 and rna and number 5. ❤thanks this video is awesome 😎
This was so so helpful - thank you so much!!!!!
Looking this up since chronic wasting disease is on the rise in deer, and obviously a lot of people like their yearly deer meat.
The Bible does mention that very old viruses will return, more stronger, because lab pros and medical industries don't leave it to God. Which is why all acient deadly diseases will come back.
In the bible, Leprosy was the first discovered diease.
very good,tjank you
T CELLS FOUR OF THEM ! CAN YOU COUNT THEM ? T HELPER , T CYTOTOXIC , NATURAL KILLER , T Suppressers THANKS ❤ BUDDY
Liver king
Great❤
This was sooo educational but also my fear is unlocked now
Aight. So if I still don’t have this in 20 years, I just take it that I don’t have it 😂 🙏 another 20 years to go
So will vit d stop me getting inflammation and therefore stop my psoriasis flare ups ?
you're the most beautiful scientist I've ever seen😍. I never new I was interested in prion disease until this day. I watched the whole video, couldn't look away.
this comment is weirdly horny for being under a video about prion disease. your mind must he a fascinating place.
@corvidae2741 how is it horny? all I'm saying is I watched the entire video, and it wasn't because I was interested in finding out more about Prion Disease. don't you get compliments? figures😒
@@emmanuelhamilton9503 'god your just so hot i HAD to finish this video about a topic i dont care about. Is this woman discussing an interesting topic in the medical field in a way i could understand? WHO CARES! Shes hot!' and, of course, 'its just a compliment, geez!' you know women are more than their physical appearance, right? or, no, based on your comment and response all you got from the video is 'woman hot'. Dont admit that the only reason you watched a video was due to the presenter being 'beautiful' if you dont want people assuming your shallow and objectify woman. I pity any woman who has to deal with you in a professional setting.
@@emmanuelhamilton9503 Yeah not really a compliment. Definitely creepy to go 'I don't give a fuck about you educating people on terrible, fatal, degenerative illnesses. I just watched you because I think you're hot.' Stop presuming women want commentary on their appearance 24/7.
@@emmanuelhamilton9503 Very simply because you see a woman on the internet and feel the need to tell them how incredibly beautiful they are, instead of talking about the very clear reason why they made it in the first place. You might see that as a "compliment" when most people will find this to be creepy
Thank you for sharing your knowledge for free. Your teaching style is amazing and the information you’re presenting is so helpful. I’m a biomed phd student trying to not get lost in the overload of new information that I’ve never needed to know before about cell signalling cytokines and cancer. I greatly appreciate people like you sharing knowledge in a very digestible and useful way. I’m amazed by your content so far!
ApoE e3/e3 genotype - just learned from a DNA test - school me on what to do - I already have metabolic disorder, HBP, pre-diabetes, 23kg overweight, Low T and Sleep Apnea
...did she really just say "Thankfully it's incredibly rare but increasing" WHAT DO YOU MEAN THANKFULLY IT IS INCREASING
Hi, Thanks for this video. Recently did the nk cells and came low. Planning to do the IVF. Whether I have to correct the NK cells before the procedure. Please reply. Thanks in advance.
What is TGF-b role in the immune system and why would be indicative of if increased in lab work?
So I took Tylenol 8 hours after the vaccine because I had a fever 103.7 did I mess up?
How much did you get paid by Billy for this ???🙄
What a scary scary illness. I’m sad for anyone that has gone through this with a loved one.
Why does she sound like AI? GREAT INFORMATION but I just feel like she's going to tell me to "download Top War to my mobile phone" when she's done
So when you consume a like species spinalcord/brain can the body not break down the prions within and they have a higher chanc eof misfolding in the digetsive system? I'm not understanding how that leads to more. Doesn't someone have to already be effected by a misfolded prion in order for them to transfer the disease through cannibalism? Or does it have a higher chance of misfolding after death??
You should try using DaVinci Resolve as your editing software.
So I could be a zombie but I'm alive with the prions made me alive because prions? I literally should be dead from the life I lived but I just keep going....
thanks alot
Great video! I am a 3/4. I am 53 year old and had a heart attach at the age of 47. are you able to keep your cholesterol low? If so what diet?
I'm not a scientist, but I know after doing some very, very light reading that prions are resistant to conventional autoclaving, and even ionizing and UV radiation -- that's absolutely crazy to me. One Google search later, and i see that the Virginia Department of Wildlife Resources stated that temperatures of 900 degrees (C) and up can reliably destroy those little buggers. Now, how that can be applied to treating a prion disease in a living being... I've no idea. Maybe a direct strike from a bolt of lightning (5 times hotter than the surface of the Sun...)? No. *NO.*
Thanks so so much for this!!
Thank you for this. how did the microclots develop due to covid and the vaccine?
still here waiting :-)
Stop eating carbs and seed oils.
Hello,greetings from Europe. Started today with 2000 iu D3. I have Myasthenia Gravis ( since1984) had a Thymectomie. I,ve read some studies where patients reduced their symptoms with D3. I,m scared to take more to be honest. This is an older video so i don,t know if you will read it. Could you please be so kind to give your opinion? Thank you in advance
THANKS FOR SHARING ❤ I HAVE BEEN HAVING BRUISING AND BLEEDING GUMS FOR SOME IVE BEEN TO DR BUT NOT MUCH WAS DONE OR SAID ❤GOD BLESS YOU ❤
Hard pass
It’s not always from a tick. It can be from any biting insect. My worst Lyme infection is a LIVE the Babesia Mycroti (like malaria) you mentioned. I also have several others. I’ve been sick for 2 years on treatment. I hurt all over! I also had mold toxicity and breast implants, which I’m finding is a common trail of infections.
Thank you so much for this valuable info.
Be very careful and evaluate people well before starting Allergen Specific Immunotherapy. I developed Relapsing Polychondritis with renal involvement in the form of mesangial nephropathy, which has evolved into fibrosis and glomerulosclerosis leading to renal failure, during the course of applying SIT with a member of CONICA, COMPEDIA in Guadalajara. There are certainly several reports in the medical literature about the induction of autoimmune diseases during SIT. SIT aims to reduce allergic symptoms by providing tolerance to peripheral T cells through the induction of regulatory T cells. By stimulating Treg cells, the Th1-Th2 balance shifts towards Th1, leading to substantial changes in the T cell cytokine profile, increasing the synthesis of IL-2, IL-12, IL-18, IFN-γ and tumor necrosis factor-β by Th1 (Those are the cells involved in the pathogenesis of Relapsing Polychondritis and Mesangial Nephropathy). My health was destroyed by SIT, just as it has been destroyed for other people. They should be held accountable for the side effects, I am now a lifelong diseased person like many others because of that damned allergen-specific immunotherapy. Be very careful.