When VLDL --> IDL --> LDL I made a rhyme that goes "VLDL has all 3, IDL was lost at sea , and LDL has lost its E" to remember which one has which receptors. VLDL - Apo B100, C-II and E (has all 3) IDL- Apo B100, E (lost at sea = lost the C-II) LDL - Apo B100 (lost the E) Maybe that will help someone haha
Step 1 in 2 weeks and I was freaking out because I think I have forgotten most of the stuff I have been learning... bing-watching your videos these days and it just give a sense of 'calm' and ofcourse, they are making eveything super easy... THANK YOU for existing
Didactics includes knowing a lot about the subject, understanding what the target audience needs to know and, mainly, knowing how to explain to let the audience learn congratulations !
1 1/2 months until my step 1 exam and before that series I havent had ANY idea of this stuff. I managed to ignore it until now and pass my biochemistry exams without even learning knowing what a apolipoprotein is. Now I feel like I know everything! Thank you!
It's wild how understanding evolves and just re-frames everything we'd previously learned. Because now all I can think watching this is: So ApoE4 which binds less efficiently to lipoproteins (effectively transporting low quantities of TG and Cholesterol) allows for more LDL to bypass the Liver and accumulate in peripheral cells increasing risk of strokes and heart attacks and carries less TG and Cholesterol to the brain for construction of myelin sheath construction and energy (cue dementia protective Ketone diet), and transports less amyloid beta to out of the brain. I know your goal was lipid Transport, but this is also helped me to consolidate ApoE4's part in dementia!
This was amazing! I finally get this pathway after trying to understand for so long! I really wish more meds student would choose to watch your videos cause their really fantastic, thank you.
Just in case anyone sees this, at 15:48 he says "LDL" (but meant HDL) when recapping the different directions for LDL and HDL. Easy to see what he meant but just didn't want anyone getting confused!
Simply AMAZING!! I take step next month and have been watching your videos every day! You've taken all the toughest concepts (and all the minutiae) to understand and saved me.
after struggling with this topic for all of 1st year and till now I finally have a strong understanding in less than 30 min on lipid transport!! Amazing is an understatement of this because im no longer scared this biochemical pathway
DM: I decided not to make it one video because I didn't want you to run home crying. **Me: watches all three back to back and bows bc THANK YOU for helping me understand more in 40 something minutes than reading/regurgitating the material from biochem books countless times without understanding it**
How I learned it. HDL is high grade : so doing good job of removing cholesterol from the arteries. LDL is low grade, splattering cholesterol into your arteries and clogging them.
That’s not it’s function though. It’s attempting to heal inflammation. No inflammation then no clogging. We wouldn’t be very efficient as a species of our body function actively worked against us
generally, very niely explained... EXCEPT regarding the bad "bad" word. Normal LDL is essential and part of life, and necessary for the maintenance of energy metabolism AND membrane integration of EACH AND EVERY cell. And I hink it is not perfectly precise that LDL particles are swalloed. Many only discharge part of their content (?). What does it make bad is oxidation of its APO proteins, which prevent re-uptake by the liver.Those LDL are completely discharged and small. They accumulate in the blood, when there is high oxidative load, because the fail to be removed, especially if HDL is low. Since they are small AND the endothelium is in bad shape, they sneak in tinot the endothelium and beneath it. There they can be detoxified only by macrophages, which get foamy, and inflammatory. HDL also get oxidized under high oxidative load (glucose, low glutathione, etc) bu oxHLD binds to oxLDL and the double bubble can get removed by macrophages. So, it is a statistical game: high HDL reduces the number of dangerous bullets. HDL is transporting cholesterol back to the liver, but that it standard homeostasis. It is the FALSE reason to call it good. The cholesterol found in plaques is there for 2 reasons. pathologically, as part of the small oxLDL, and as part of the healing process, which needs cholesterol for new cell membranes. perhaps you could say also a word about Lp(a) here
Omg, this was a fantastic way to break it down. And the mnemonics for lipid transports are way too good. I've written all of them down on my First Aid.
Don't know if this will help anyone, but an easy way that helped me memorize the function of ApoA1, was by saying ApoA1 "Ages" HDL. Idk why but it's short and really stuck for me, so putting it on here. Hope it helps
I died when you said ''hey my name is LDL and am here to be inside of you" dirty medicine ended.hehe loveeee your videos dirty keep up the amazing job.
“There is a lot of d’s” you said Deez what sir? Greetings from turkey lol 1st grade medstudent here working for finals. as you mentioned your videos are a little bit undetailed but they do a huge job on understanding the big picture thanx a lot
Mom: Are you watching those digital touchscreens again. You can't gain nothing but eye issues. me: Nope mom. I'm watching dirty youtube lectures. Mom: what? dirty lectures? my god Me: don't get me wrong mom. I'm attending biochemistry class that goes by the name "Dirty Medicine"
I am a newbie and very thankful for your easy to understand walk through. But, pls excuse my ignorance: Why is it bad to transport cholesterol to the cell? Isnt cholesterol needed for maintaining the cell membrane? What happens without LDL?
It’s only bad when you have very high levels. When you have too much, the LDL will deposit lots of fat and cholesterol in the wrong places such as your artery walls. This leads to atherosclerosis and coronary artery disease.
i loved the three part series.....but you literally stopped at the chylomicronin remnant the liver, what happens next.......how does this connect with beta oxidation. Excellent breakdown of the apoprotien
I finished all 3 videos of lipid transport and I have to say, it made my life way way easier. Thank you!!!
When VLDL --> IDL --> LDL I made a rhyme that goes "VLDL has all 3, IDL was lost at sea , and LDL has lost its E" to remember which one has which receptors.
VLDL - Apo B100, C-II and E (has all 3)
IDL- Apo B100, E (lost at sea = lost the C-II)
LDL - Apo B100 (lost the E)
Maybe that will help someone haha
thank you
lovely! thanks :D
Dirty you deserve 1 million subscribers
I think way more than 1 million within a year… very nice effort, very nice way of teaching and simplifying complicated topics… excellent job 💐💐👏🏼👏🏼👏🏼
i think he desreves more.. he makes everything supersimple
4 years later and this video is still the best! Thank you so much!
Step 1 in 2 weeks and I was freaking out because I think I have forgotten most of the stuff I have been learning... bing-watching your videos these days and it just give a sense of 'calm' and ofcourse, they are making eveything super easy... THANK YOU for existing
How did you do, any tips?
Hey! Do you have an update?
I’m a medical student from Thailand . Thank you for your hard work!! ❤️❤️❤️❤️
Didactics includes knowing a lot about the subject, understanding what the target audience needs to know and, mainly, knowing how to explain to let the audience learn
congratulations !
1 1/2 months until my step 1 exam and before that series I havent had ANY idea of this stuff. I managed to ignore it until now and pass my biochemistry exams without even learning knowing what a apolipoprotein is. Now I feel like I know everything! Thank you!
This is work of a genius!
Excellent video, you are by far the best medical channel on TH-cam.
Shantanu Nair world*
Or another mnemonic for HDL and LDL is: HDL= H*ealthy cholesterol, LDL= L*ethal cholesterol. FA being my reference though
Good one!!
It's wild how understanding evolves and just re-frames everything we'd previously learned. Because now all I can think watching this is: So ApoE4 which binds less efficiently to lipoproteins (effectively transporting low quantities of TG and Cholesterol) allows for more LDL to bypass the Liver and accumulate in peripheral cells increasing risk of strokes and heart attacks and carries less TG and Cholesterol to the brain for construction of myelin sheath construction and energy (cue dementia protective Ketone diet), and transports less amyloid beta to out of the brain. I know your goal was lipid Transport, but this is also helped me to consolidate ApoE4's part in dementia!
HDL is such a favourite student you can just tell, the teacher finds it extremely helpful
This was amazing! I finally get this pathway after trying to understand for so long! I really wish more meds student would choose to watch your videos cause their really fantastic, thank you.
Apo E , "E" for end , they have reached the end of their job and are ready for reuptake
Thanks
Just in case anyone sees this, at 15:48 he says "LDL" (but meant HDL) when recapping the different directions for LDL and HDL. Easy to see what he meant but just didn't want anyone getting confused!
Dude I know these vids are older but I'm taking COMLEX/STEP 1 in 2 weeks and they're literally saving my life. TYSM Dirty!!!
I LOVED LOVED LOVED THE SERIES. THANK YOU VERY MUCH
These videos are INSANELY amazing!!! Thank you!!!!
Seriously, those three videos are awesome. Thanks!
Thank you man, you’re just a god send. I pray for u have a good day and a good life. Cheers
Simply AMAZING!! I take step next month and have been watching your videos every day! You've taken all the toughest concepts (and all the minutiae) to understand and saved me.
RR Adventures all the best!
@@suminarai7910 Thank you!! All the best to you as well!
@@rradventures1766 how did it go? i'm taking mine in feb
after struggling with this topic for all of 1st year and till now I finally have a strong understanding in less than 30 min on lipid transport!! Amazing is an understatement of this because im no longer scared this biochemical pathway
You deserve the noble price!
DM: I decided not to make it one video because I didn't want you to run home crying.
**Me: watches all three back to back and bows bc THANK YOU for helping me understand more in 40 something minutes than reading/regurgitating the material from biochem books countless times without understanding it**
Thank you, Jesus, for this awesome teacher!! With profound appreciation!
Amazing! Thank you so much or the 3 videos on Lipid transport - wouldn't have been able to understand it without your videos.
Agree
I finally got a clear picture in my mind about what's going on in these complex pathway. thanks a lot
How I learned it. HDL is high grade : so doing good job of removing cholesterol from the arteries. LDL is low grade, splattering cholesterol into your arteries and clogging them.
That’s not it’s function though. It’s attempting to heal inflammation. No inflammation then no clogging. We wouldn’t be very efficient as a species of our body function actively worked against us
Thank you for teaching lipid transport with so much clarity !!! 🙏🏽
After these 3 videos , I feel to loose all burden of biochemistry from my back
well said 🤣🤣🤣
Thank you SO MUCH! It’s so refreshing to learn something by understanding than by just rote learning.
i was so confused until i watched these three videos. THANK YOU so much. I subscribed!
been putting these off for so long and now i have mastered these concepts in my dedicated period; thanks dirty you are the best
Any of you people who have an upcoming exam need to send this guy a check.
GOAT- Greatest Of All Teachers. Thank you,thank you and thank you.❤❤❤❤❤
generally, very niely explained... EXCEPT regarding the bad "bad" word. Normal LDL is essential and part of life, and necessary for the maintenance of energy metabolism AND membrane integration of EACH AND EVERY cell. And I hink it is not perfectly precise that LDL particles are swalloed. Many only discharge part of their content (?).
What does it make bad is oxidation of its APO proteins, which prevent re-uptake by the liver.Those LDL are completely discharged and small. They accumulate in the blood, when there is high oxidative load, because the fail to be removed, especially if HDL is low. Since they are small AND the endothelium is in bad shape, they sneak in tinot the endothelium and beneath it. There they can be detoxified only by macrophages, which get foamy, and inflammatory. HDL also get oxidized under high oxidative load (glucose, low glutathione, etc) bu oxHLD binds to oxLDL and the double bubble can get removed by macrophages. So, it is a statistical game: high HDL reduces the number of dangerous bullets.
HDL is transporting cholesterol back to the liver, but that it standard homeostasis. It is the FALSE reason to call it good. The cholesterol found in plaques is there for 2 reasons. pathologically, as part of the small oxLDL, and as part of the healing process, which needs cholesterol for new cell membranes.
perhaps you could say also a word about Lp(a) here
You’re amazing! I’m totally sponsoring your pattern when I get a residency.
Awesome video and Thank you very much. Please post more!
I spit out my coffee when you said "I'm LDL and I'm here to be inside of you" LOL
Truly the best explanation of Lipid Transport! Thank you so much
I watched many videos that used different techniques and yours catered the best to what I just needed. Thank you.
Omg, this was a fantastic way to break it down. And the mnemonics for lipid transports are way too good. I've written all of them down on my First Aid.
This video saved me from reading numerous pages....🙏🙏🙏🙏
hey im a Microbiologist this video so crisp and clear thank you for your effort
Thank you so much. I have finished watching all three videos and they were extremely helpful.
Your dirty mnemonics are the only dirt i love in my life
Thanks!!
"Apo E = enter liver" always gets the job done for me
the world is a better place because of you
Thankyouuu!!!!!!!!!! Do u know how much you’re helping people ???
Man, I love you. Still useful for step2
7:14 gonna be my lick up line from now
@dirtymedicine Thank you for sharing your love and wisdom of life through this humble medium... A mini book will be well to come off these videos.
thankyou so much !! this made so much sense. YOU ARE AN ABSOLUTE SAVIOUR!!
Medicine : Endocytosis of LDL
DIRTY Medicine : hey i'm LDL , i'm here to be INSIDE of you
Don't know if this will help anyone, but an easy way that helped me memorize the function of ApoA1, was by saying ApoA1 "Ages" HDL. Idk why but it's short and really stuck for me, so putting it on here. Hope it helps
I watched Ninja Nerd first but was so overwhelmed. Your video has made my resting heart rate go from 150 to 90 bpm. Thanks a lot. Kisses !!!!!!!!
Thank you buddy, you just saved a life
I died when you said ''hey my name is LDL and am here to be inside of you" dirty medicine ended.hehe loveeee your videos dirty keep up the amazing job.
this was such a helpful series! thank you so much!!!! never understood or could remember this stuff in med school, but hoping it sticks for the STEP.
Thank you so much doctor, your videos are so helpful you truly have a gift to teach.
you are amazing , Father of biochemistry
Thank you so much. I really benefited from this series. God bless you
I'll never understand who the hell dislikes these videos
Your videos make online classes so much easier. Thank you so much
You are a God-sent person, my good Sir 🥺🙌
you are a legitimate angel. Bless you!!
thank you❤❤you made it really easy.. these mnemonics and stuff made everything clear
7:12 real smooth my dude
this helped me so much oh my god I feel so much better for my exam on Wednesday thank you!!!1
Time for changing way of thinking. LDL is not bad. The body is not stupid to create something to harm itself...
Then explain cancer
You are doing Gods work. Thank you
Why is it harmful if LDL goes into the peripheral cells if there is a receptor for it. What function does it have in thr peripheral cells?
Awesome explanation and mnemonic. God Bless You!!
You have saved us all
amazing set of videos!
“There is a lot of d’s” you said
Deez what sir?
Greetings from turkey lol 1st grade medstudent here working for finals. as you mentioned your videos are a little bit undetailed but they do a huge job on understanding the big picture thanx a lot
Probably low-yield, however FA states the IDL still has Apo CII on its surface.
Simply You are awesome. Thank you so much for made it easy.
Okay I feel confident now
Something is better than nothing thanks a lot
You're ridiculously good. Wow. Thank u!!!!
This saved my ass. HIGH YIELD 👌🏻
Just pass biochem thanks you bro❤️
Mom: Are you watching those digital touchscreens again. You can't gain nothing but eye issues.
me: Nope mom. I'm watching dirty youtube lectures.
Mom: what? dirty lectures? my god
Me: don't get me wrong mom. I'm attending biochemistry class that goes by the name "Dirty Medicine"
I am a newbie and very thankful for your easy to understand walk through. But, pls excuse my ignorance: Why is it bad to transport cholesterol to the cell? Isnt cholesterol needed for maintaining the cell membrane? What happens without LDL?
Exactly! Bad way of thinking and misconcepts. The body is not so stupid to create something to harm itself...
It’s only bad when you have very high levels. When you have too much, the LDL will deposit lots of fat and cholesterol in the wrong places such as your artery walls. This leads to atherosclerosis and coronary artery disease.
This is awesome...currently looking at this in two separate classes and felt like I was missing something for full understanding, until now!
You r the best drty medcne 🇮🇳
Tks very much for wonderful lecture on bio Chemistry of lipoproteins.
awesome and brilliant... thaank youuuu
wonderful series, thank u very much.
i loved the three part series.....but you literally stopped at the chylomicronin remnant the liver, what happens next.......how does this connect with beta oxidation. Excellent breakdown of the apoprotien
Extraordinary and superb explanation
You are THE BEST
Thanku so much really ❤️❤️❤️❤️
Hi! When are you gonna take 1st step?
Great 👍
You brought so much clarity, great work
Thank you for saving me!! Great videos as always!
Thanks man, You made my life oh so much easier today
thank you so much