Hi Dirty , you have absolutely saved my life. I have been dealing with this topic( + anti diabetics , which i also watched ) for the longest time but right now , i feel confident to answer any question in these sections . I have step 1 in 2 weeks and i promise to give back to this community when i start earning . You are the absolute best . Thank you from the bottom of my heart
for PCSK9 inhibitors Pesky (PCSK-9) muhammad ali (ALIrocumab) Evolved (EVOlocumab) boxing. This also helps us remember the side effects because you have NEURO effects and soreness (mylagias) from boxing
My exam is in 2 months and your videos are so essential during this period. You just simplify everything, especially pharma which is so hard to memorize. I watched your video on HIV drugs and I answered the UW questions like it was nothing. Now I guess the lipid lowering agents will be a piece of cake as well. Thank you so much!
exam in 10 days, coming in clutch with this topic cause first aid had a lot going on with those visuals (same with sketchypharm), but you made this v easy to follow👍
To remember the ↓ LDL exceptions, Fibrates and Niacin, I added this little mnemonic: fibra↓Tes (↓ TG) and "Nancy is extra Hot!" (Niacin - ↑ HDL - flushing) For remembering the majority decrease LDL, I remember "All the fatties drop it LOW LOW" (Lipidemia drugs ↓ LDL lol)
Hi!!! Greetings from Brazil! I love your videos! They are incredibly objective and accurate! I just wanted to say thank you so so much and please keep it up! Also, just a small correction: estatins are actually competitive inhibitors and not alosteric inhibitors: they bind to the active site of the enzime HMG-CoA-redutase, taking the place of the substrate HMG-CoA, as opposed to binding to the allosteric site and inducing a conformational chance of the enzime that makes the binding of the substrate to the active site impossible.
Thank you for the video! one thing to clarify...don't fibrates also increase HDL? via PPAR-a? the take-home points at the end only point out that niacin increases HDL, and that fibrates just reduce trigs
hey just a question because you had said the Fibrates second pathway via PPAR a increases the HDL: which would mean that HDL would be increased for both Niacin and Fibrates how come you only put a decreased quantity of triglyceride in fibrates?
Thank you for your incredible generosity in the work you do! You are making the world a better place in a big way! Have you ever considered a life time membership option? I would love to support your work and my ongoing education for life. Dr. Been has the option of one time payment for unlimited access and I love the idea! ✌️ Liz Dean
Bottom line seems to be that FDA was concerned enough about cognitive changes. Be it statistically significant or not, it is worth knowing about imo: link.springer.com/article/10.1007/s40264-015-0296-6 www.ahajournals.org/doi/epub/10.1161/CIRCRESAHA.118.313238
Dirty, you are that guy. Thank you for contributing to all of our success!! You are a great teacher and great person in general!
Hi Dirty , you have absolutely saved my life. I have been dealing with this topic( + anti diabetics , which i also watched ) for the longest time but right now , i feel confident to answer any question in these sections . I have step 1 in 2 weeks and i promise to give back to this community when i start earning . You are the absolute best . Thank you from the bottom of my heart
Dirty, you did it again. you really did do a better job teaching this than ANYONE else. and in the nick of time for my exam!
HM*G (good for) *CO A (coronary artery)
this is literally the most brilliant little trick ever my jaw is on the floor hahha
Genius. Will never forget this
Thanks!
for PCSK9 inhibitors
Pesky (PCSK-9) muhammad ali (ALIrocumab) Evolved (EVOlocumab) boxing.
This also helps us remember the side effects because you have NEURO effects and soreness (mylagias) from boxing
ahhh,THANKS DUDE!
Thank you!
Hehe thank youu!
My exam is in 2 months and your videos are so essential during this period. You just simplify everything, especially pharma which is so hard to memorize. I watched your video on HIV drugs and I answered the UW questions like it was nothing. Now I guess the lipid lowering agents will be a piece of cake as well. Thank you so much!
Dude, you're like a magical teacher that I go to when ever I stuck in a subject.
Dirty medicine is by far my favorite learning tool. I have not purchased a text book in my FNP program yet. Thank you !!!
How’s school going? I’m in year two FNP. I love these videos.
exam in 10 days, coming in clutch with this topic cause first aid had a lot going on with those visuals (same with sketchypharm), but you made this v easy to follow👍
It’s a measure of how interesting your videos are when I’m watching them on my break after exams lol
might be your best video
Perfect time for my pharm test tomorrow. Thank you so much!
Thank you so much! Will definitely support via membership once I start earning! THANK YOU
To remember the ↓ LDL exceptions, Fibrates and Niacin, I added this little mnemonic:
fibra↓Tes (↓ TG) and "Nancy is extra Hot!" (Niacin - ↑ HDL - flushing)
For remembering the majority decrease LDL, I remember "All the fatties drop it LOW LOW" (Lipidemia drugs ↓ LDL lol)
Thank you so much for your support 🇪🇸👏🏽👏🏽👏🏽
Hi!!! Greetings from Brazil! I love your videos! They are incredibly objective and accurate! I just wanted to say thank you so so much and please keep it up! Also, just a small correction: estatins are actually competitive inhibitors and not alosteric inhibitors: they bind to the active site of the enzime HMG-CoA-redutase, taking the place of the substrate HMG-CoA, as opposed to binding to the allosteric site and inducing a conformational chance of the enzime that makes the binding of the substrate to the active site impossible.
running out of things to comment in your videos but they really are helpful
Thank you so much! You have no idea how much anxiety this topic gave me before this video.
Great video. I'm currently studying to be an FNP and your content gives such great overviews of different content areas.
I used your channel and I passed pharm 1, using rn to see if i can pass pharm 2, great work sir
Just what I needed. High-yield.
Your teaching method helps to register and retain facts...
Thank you so much dirty medicine! Watching your videos makes me forget all the other resources Im using.
@Dirty med my exam is next month. Kindly upload one video on Adrenergic system.
P.S: Thank u so much for every video. May God bless u for that
thanks for the table at the end!
really was the best explanation i ever heard thus far ! :)
you promised making it easier for us and you kept your promise. KUDOS😍😇
9:47 "but who cares?" cracked me up. Thank you
WOOOOOW thank you so much! much love from DR
Thank you for the video! one thing to clarify...don't fibrates also increase HDL? via PPAR-a? the take-home points at the end only point out that niacin increases HDL, and that fibrates just reduce trigs
Can you please upload a video about opthalmology (especially fundoscopic images )
No
this man the goat
My exam is in June and I'm clenching my pearls rn
Same
Mine's in July. We got this!
Thank youuuu so much!!! THIS literally saved me!
Dirty you are super clean with concepts🎉😅👏🏻
Excellent explanations
thank you for saving my life!! 😭😭❤️❤️
Could you please make a video on diuretics? Thank you
The best explanation, Thank you 👍
In portuguese they translated "Bile acid resins" to "Bile acid kidnappers" which is just 1000% better
It can be named as “bile acids sequestrant” in Europe!
Great video as always. What about Thiazolidinediones?
Thanks Dirty! Mnemonics: NPCs are Eze. LFTs are Eze. EzetimIBe Intestinal Brush border.
Amazing work dude 👍keep going
Amazing Lecture!
Not the nerdy academic career 😂 ! Great video
Much needed!!!!
Thankyou God sent angel
Great video! Tweaked the mnemonic for myself: primate has the "gal" to act like a PPAR-t-a of the human species.
Thank you very much bro. 🥰
You're a legend, dirty 🙏🏻💯
what an awesome explanation!!
Your lecture is so easy to understand and ty for your contribution!!!
super helpful video, thank you!!
Thank you Dirty, just a question. Fibrates also increase HDL through PPAR-a activation right?
you are the best!
Primates bring stones to the PPARt-ay 😂
hey just a question because you had said the Fibrates second pathway via PPAR a increases the HDL: which would mean that HDL would be increased for both Niacin and Fibrates how come you only put a decreased quantity of triglyceride in fibrates?
HDL would be increased by Niacin only.
Thanks
Its so helpful, thanks so much!
Life saver video
amazing, just wanted to mention that resins can increase TGs by increasing VLDL
Wow ! Really 😲
HOW?
WILL YOU MIND TO EXPLAIN IT
Thank u so much for this video
Thanks a lot sir
love this channel
Not being mean bro, but your voice soothes me to 😴 stay awesome
From somalia you are one in billion
You're amazing
Hi is Fibrates for inc HDL and niacin inc HDL is in error?
Thanks sir!
Thank you very much 🙏
Thank you!
thank you
This guy is good
You can use "NPCs wearing TIMs are at the IBorder" for the ezetimibe if you need a mnemonic
Cholestrol is not bad it's the oxidised lipids which are nd in presence of glycation..the combination results in CVD
Please come and teach at our college
how can i will find this pdf??
the GOAT.
Thank you for your incredible generosity in the work you do! You are making the world a better place in a big way! Have you ever considered a life time membership option? I would love to support your work and my ongoing education for life. Dr. Been has the option of one time payment for unlimited access and I love the idea! ✌️ Liz Dean
cant thank u enough
Thnk u so so much
So thank y dr.
Thnk you🌟🌟🌟
Awesome
salute to u
Its the mnemonic juicelord himself
Good
Dirty is crazy man love this guy
You are theeeeee besssttt!
Do you have a source on the dementia adverse effect?
Bottom line seems to be that FDA was concerned enough about cognitive changes. Be it statistically significant or not, it is worth knowing about imo:
link.springer.com/article/10.1007/s40264-015-0296-6
www.ahajournals.org/doi/epub/10.1161/CIRCRESAHA.118.313238
Note: PPAR-Gamma was mentioned in the insulin drugs "Bring Glitta to the party"...Glita was the drugs of TZDS and Party MoA
Thank you ^_^
Love from Russia 🎉
Thank you dirty ❤
Find the odd one out
1. Atorvastatin
2. Simvastatin
3. Nystatin
4. Rosuvastatin
Nystatin because it is antifungal and others are not
Where is Chromium?
Thanks a lot dirty medicine🙏
💯
❤❤