Insulin Secretion
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- เผยแพร่เมื่อ 27 เม.ย. 2020
- In this video, Dr Mike explains the different stimuli that can trigger the secretion (release) of insulin from the pancreas.
This includes nutrients like glucose, amino acids, fatty acids, and ketones. But also the autonomic nervous system and other hormones of the body!
My only issue with this video is that your biceps are distracting me from learning the content 💪
Points:
1. Glucose enters cells through GLUT 2 transporter on the Islet cells of the pancreas
2. Glucokinase phosphorylates glucose to make Glucose-6-phosphate. G6P turns into pyruvate via the glycolysis pathway.
3. Pyruvate then enters the mitochondria to make energy via the Krebs cycle and also undergoes oxidation at the membrane of the mitochondria. The result is production of ATP that is produced from ADP.
4. The potassium channel remains open with ADP bound to it so K+ moves freely through it. Once more ATP is made, the ATP binds to the K+ ion channel to "close its lid" - increasing K+ in cell. As the cell becomes more positive on the inside, the Calcium channels open to push the vesicles that hold insulin to merge with the islet cell membrane and release its contents
You are the unsung hero man. Thank you.🫡
Thank u soo much ❤
And how k+ is produced in the cell and from where it is coming
Why didnt i find these sooner 😑i have been studying all the steps at different times so I couldn’t see the big picture of how it all works actually i just understand all so clearly now thank you 😊
Seriously can’t THANK YOU enough!! This is another topic that makes my brain melt. You have a way of explaining to where I can somehow understand, therefore… remember it!!
I'm a vet student and your videos helped a lot ... much appreciated!
Thanks Doc this is the most simple and complete explanation I've found.
Most problems happen at the protein channels called a channelopathy that can be inherited or acquired. The acquired channelopathies are disrupted due to heavy metals chemicals that disrupt the protein channels as well as causing oxidative stress to the channel itself or to the cell membrane. great videos and would love to see more info on the cofactors that make the enzymes work. thank you for the great explanations...
Amazing video and description of GLUT2! Makes the rest of the process regarding insulin secretion easier to undertsand.
Student of Zoology here. Your videos are really helping me for preparing for my finals . Thank you so so so much.
when I need clarification I always check your videos first. Thank you !!!!!
You are a phenomenal teacher.. I never thought I'd ever like chemistry and biology...you made me think that maybe I should've chosen to study medicine...
Thank you Dr Mike, I really appreciate how you made understanding the endocrine system a very easy. 😉
I am going to watch alla of your videos in the summer. Fantastic! Thank you.
My life is easier with this channel.🙌🏽
Your videos are absolutely amazing!
This was an amazing refresher for me!! And probably even a better explanation than when I first learned it :D Thank you for an excellent breakdown!
Amazing explanation!!! You make Any concept a lot simpler!!! thank u so much
Wow! Doc, awesome video. I was impressed. Thanks!
Your videos are so great! its easy to understand!!!
Perfectly clear. Thank you
Excellent, ur skills as well ur physique
Inspired by both, keep it up Dr
Waiting for more, thank you Dr
Brilliant!! Thanks, please keep doing these videos mate :)
Perfect explanation thank you doctor
Excellent video. Thank you.
superb sir well understood and easy to follow.
Really great and informative lecture,thanks alote sir
Great Information 👍
i cant thank you enough dr.
So if we say that insulin vesicles release is a quantitive measure of how much insulin should be released, then where is the sensor that determine how much vesicles should be released? I mean who determine let's say the release of S, M, L, XL amount of insulin in response to S, M, L, XL amount of glucose increase in blood due to small candy(S), donut(M), meal(L), ice-cream jar(XL). Is it the K+ channel activation via ATP concentration (S, M, L, XL ATP concentrations) or is it something else? anyone knows?
what the helll maaaaann how can you be so perfect???? istg im sure all of my profs are so jealous from you
❤❤❤ thank you for making this video. It is full of knowledge..
Superb.
Another great vid
hey Doc! just brilliant explanation. well done mate.
Nice thx Dr ... you are the best 👌🏻
Great video mate
Pls put translator in the explainer videos,we follow u from the Middle East, and keep going 💚💚
You are a blessing.
Great explain. Thanks.
I have just been diagnosed with insulin resistance. My 1-hour values were 5x the normal range. Is keto and metformin my only option?
Please throw more highlights on insulin and ATP
Hi Doc, love your vids. I am confused about how insulin is actually released. Do the beta cells respond to glucose already in the blood stream which I presume would be a ongoing process so long a glucose remains high? Or is insulin only released upon ingestion of food?
Hi
Sir you are doing a good job.you are my teache.
May God make ease for you.
bloody brilliant!
Thank you Dr.
Dr Mike all the way 💞🙏👏
thank you doctor
you are the best
Thanks for explaining all of this but how do you regulate insulin release if your insulin is too high? Potassium and sodium? I feel like missing that part.
I think my insulin may be high because while my glucose is normal, i fast, and watch my calories, i think my insulin is still too high and preventing me from losing weight.
Any info is appreciated. Thanks 🙏🏾
Thanks for your AMAZING Videos!!!
But isn't it GLUT1 (and GLUT3) which transfers glucose into the beta-cells instead of GLUT2?
Hi Dr Mike, great explanation,
But all Diabetics looking for a full cure,
Thanks very very much❤❤
Hello Dr M's. Can you tell me what the strength of natural, pancreas produced insulin is? Similar to U-100 R ?
Awesome!
You are amazing 🙏🏼🙏🏼🙌🏼🙌🏼💪🏼💪🏼
Am I right that depression, stress (high cortisol) and smoking (jumps of adrenaline and noradrenaline) killing my cells through that process? For the last 6 month I lost about 15 kg of healthy weight and look much older. Increased insulin I guess just drained me. Besides i am sure that I pretty healthy in general or was. So there is some real guidelines about how to fix my hormone system, which blood analysis pass at first? p.s professional medical help very expensive so I need to figure out by my self
Wow! I’m a lot more smarter than I was 15 minutes ago! 🙏🏻🙏🏻🙏🏻
Thank you very much indeed
U r amazing♥️
You're the best
Mahalo Dr. Mike
No you can't measure a charge difference in millivolts, the charge difference needs to be in Coulombs. You mean that, charge entering or leaving the cell changes the potential difference
I have a question, that is, insulin is both produced and secreted by beta cells then how does decreased insulin release by adrenaline is an alfa2 effect?? Same for glucagon - produced by Alfa cells but increased release by adrenaline is a beta2 effect??
So how do they say that artificial sweeteners cause insulin release since they don’t produce glucose?
When does Insulin starts secreting: as soon as we start chewing or after the food reaches stomach?
here's what happened - I wasn't even going to understand it because in my school I don't have to go into so much detail about physiology. But I watched this video and inadvertently understood how insulin secretion is stimulated. How is this even possible? 😂
Dr. Mike💪 😍
glucose energy intake why break down and waste or process of waste is important related to diabetes relationship
Does beta cells need insulin to absorb glucose to produce pyruvate?
Does beta cells bind to alpha cells?
The best
Enzymes 👍
Can you be less handsome that my pervert ass can give proper attention to my study😭
👏👏👏👏👏👏👏👏👏👏👍
I'm too dumb for this
Sir good but make the video explanation long & conceptually.
sir good but? c'mon man
Why you explain so fast ,but instead of this all of your video are good.
there is a button to decrease the speed.
Man...
This bony professor explained fully abut the humans number one illness ..
Now I can fight my home doctor about his cheating me in diagnosing my illness..
0:40 lowkey laughed
Ur teaching skill is very killer Ur body ,Ur chest is very attractive and only these thing attracting me too see Ur vedio love you
👍🇧🇷👀
You are so handsome!
0
you write toooo small, difficult to read