I have seen his videos for too long and this is the first time i see him making such a mistake. Anyway we were able to catch it and could use the rest of the class
he was keep saying diaphragm diaphragm diaphragm , didn't you all hear that ? he also writed "diaphragm " multiple times . you guys need to focus while studying . Good luck
I was diagnosed with HL last week. I’ve watched this 3 times, and it is so well done! I have a really good handle on what’s happening in my body thanks to this. Really educational stuff
6 years in remission over here. You're going to get through this, you wont know how you'll get through it, but you will. Good luck to you, you've got this
@@chloeclo7 thank you very much. PET results came this morning: stage 1A. About as good a starting place as could be… I mean as the video states any stage is curable, but the lesser the better
@@Miyanazuki so far so good. 1 cycle of chemo so far with one to go. My neck lymph nodes are completely shrank down to normal looking at this point. I’m feeling good
recently just finished my treatment for hodgkins lymphoma stage 2 and ever since i finished treatment i have been so incredibly curious of how it works, so thank you so much for this video!!
@@junefreeman7955 so essentially it was entirely chemo since radiotherapy was too dangerous long term due to the locations of my cancer, i initially had 2 courses of ABVD with no unexpected side effects, a pet scan after those courses showed that only a small amount of cancer remained and in turn i had 2 courses of BEACOPP with a PICC insertion, thankfully after that i was cancer free, fortunately i was just young enough to be in a children’s hospital (the food is immaculate)
Hello from Brazil , I just wanted to say that I really like your classes they are very detailed and very well explained , whenever I have to remember some basic concept I go back to one of your videos and suddenly everything makes sense , yours enthusiasm for teaching is contagious and on top of that you make it all available for free on youtube and on your website it seems almost too good to be true, and I just wanted to thank you and your team.
Thumbs up team!!! Thought very necessary to add that the Ann Arbor staging got muddled along the way viz: * ' On either side of the diaphragm ' refers to grom chest upwards and abdomen below as opposed to on either side of the chest. "A single extra nodal involvement is still stage 1 in the absence of a lymphadenopathy .
Great video. The description of stage III CHL was stated correctly, but I think the drawing for stage III is slightly incorrect. While it includes both sides of the mid-line (which is shown in the diagram), it also includes both sides of the diaphragm, which was clearly stated, but not draw on the diagram.
This is probably the most advanced lecture i saw about Hodgkings. I really love the way you lecture,and with all the stuff writen and showned. I just wanted to tell you that you should add on this video about 5 minutes about radiation therapy in treating Hodgins. I am medical physicist and we radiate lot of patient with Hodgins, cervical , clavicular, axilary, mediastinum, and nodes bellow diaphragm. Keep doing i really loved your work
Dear zach please rectify ann harbor staging , if H.L is present on both sides of diaphragm above and below not side by side it is stage 3 and if on same side it will be either stage one or two
That's not quite right. Just the neck (one side or both) is stage 1. Neck and chest is stage 2. Neck, chest and abdominal area is stage 3. Neck, chest, abdomin and groin is stage 4. Speaking as a stage 3 HL survivour
@@chloeclo7 Stage I: involvement of single lymph node region or single extralymphatic site Stage II: involvement of two or more lymph node regions on same side of diaphragm; may include localized extralymphatic Stage III: involvement of lymph node regions on both sides of the diaphragm; may include spleen (Ills) or localized Stage IV: diffuse extralymphatic disease (e.g. in liver, bone marrow, lung, skin) Hodgkin's Disease
I don't ever drink, and the main reason is that for a few years I experienced pain in the back of my head everytime I drank alcohol. Thanks to this video I now know why. Very common in people with HL
Fantastic Very clear and pleasant way But in staging in min 52 (both sides of diaphragm means above and below diaphragm not to the right or left ) thanks for the magnificent lecture
Just diagnosed with non Hodgkins lymphoma. So I'm watching this first and then the non Hodgkins video. I love how you explain with you drawings and knowledge. 2024. I'm getting monoclonal antibodies. Gazyva and Venclexta!! newest rx
Dear Dr. Zack, I am very grateful for all your amazing videos. They are of a great help. But Regarding the Staging of Hodgkins lymphoma, it is determined according to the presence of lymphadenopathy above or below the diaphragm. not the right or the left sides of the body Stage I: Either of the following means that the HL is stage I: HL is found in only 1 lymph node area or lymphoid organ such as the thymus (I). The cancer is found only in 1 part of 1 organ outside the lymph system (IE). Stage II: Either of the following means that the HL is stage II: HL is found in 2 or more lymph node areas on the same side of (above or below) the diaphragm, which is the thin muscle beneath the lungs that separates the chest and abdomen (II). The cancer extends locally from one lymph node area into a nearby organ (IIE). Stage III: Either of the following means that the HL is stage III: HL is found in lymph node areas on both sides of (above and below) the diaphragm (III). HL is in lymph nodes above the diaphragm and in the spleen. Stage IV: HL has spread widely into at least one organ outside of the lymph system, such as the liver, bone marrow, or lungs. Thank You.
Kindly help me in this disease bcoz my uncle has thi Hodgkin's lymphoma and we are worried that whether we should go for chemo we don't know what to do and uncle is becoming weaker n weaker day by day ...
Great lecture, really helpful - just provinding feedback regarding lymphoma staging - Stage 3 is both sides of the diaphragm whereas your illustration has an ipsilateral/contralateral depiction.
❤❤❤❤❤ We can see the dedication of your loving parents through your emence knowledge and way of educating this world with your amazing presentations. Love you little boy and your kind parents
Thank you so much ❤this is exactly what I am going through mind boggling 4th doctor playing games with my life waiting for referral for treatment to oncology hematology
Great video, I was diagnosed with classical hodgkin lymphoma stage 2b. Had 2x cycles of abvd but moved onto escalated beacopp-dac. Had 4 cycles and got me into remission, but now having radiotherapy to the mediastinal. Currently 6 sessions done and 9 left. Thanks for the video 😊
@rociolahere6637 yes thanks i have completed all the treatments, and now I will be seen every 3 months for checkups and a blood test. It's been a hard 9 months, that's for sure.
Hi just after my first chemo shoot for Stage 1 classical Hodgkin's lymphoma multicellular. Looking for some understanding. Can only say finally found. Thank you.
Zack you're wonderful!!! this video make my information go high in Hodgkin's Lymphoma and that's because of your very good tutoring. best luck for you man.
I hit the like button before I even start lol really I can’t thank you enough And the way that you teach and simplify things is just amazing it makes me want to learn more Thanks a lot 🙏
hello professor Zach, good job keep it up, my comment is on the staging " on both sides of the diaphragm" is to mean above and below the diaphragm, not right and left sides
My cousin has just been diagnosed with T cell rich B cell lymphoma She originally went to her Dr 15 months ago with Autoimmune hemolytic anemia that was treated with Rituxinab and Prednizone. After getting her Hemoglobin up within a normal range they attempted a sample from the bone marrow with no success and decided to wait and see how her response was. About two months later anemia was back so they added a drug used in transplant patients along with more Rituxan infusions. They made note her spleen was enlarged but thought possibly due to Covid. ( she did contract Covid two weeks prior to this second bout with anemia) She just continued to improve a bit only to have her hemoglobin dip, seemingly faster each time. About 6 weeks ago she collapsed, they put her in the hospital and decided her spleen has to go. It was 5-7 times the normal size loaded with cancer. She became very confused. Very anemic and on top of that they found hypercalcenia. Her result of Bone marrow sample said 95% cancer. Not sure what they mean by that. They’ve recently said she has T-cell rich Bcell lymphoma. Help!! I’m guessing this is really bad!
loved this but isnt there a mistake for the ann arbor classification ? like for stage III, both sides of the diaphragm means both under and above the diaphragm i think
50:44 i thought same side meant lymph nodes were grouped together superiorly vs inferiorly (as in the cutoff is the horizontal line that demarcates above vs below diaphragm) not left vs right (hemidiaphragm) can somone confirm?
yes, the classification shown in the video is wrong. If you do a google search of ann arbor classification (Lugano's revision) you'll find the right one.
In 10:31, shouldn't the B-cells be the ones that express the antigen on their MHC class 2 molecules, not the T-cell? And that the B-cell activate T-cells, and let them produce specific cytokines, such as IL-4 and IL-5, which will induce the class switching?
Correct. Good lecture, but I think the Ann Arbor staging was mistaken here. It’s based on whether the LNs or above/below the diaphragm, not based on which side of the body (left vs right).
hey great video as always, i am a huge fan, depending on you in my medical years, but in the ABVD treatment the V stands for Vinblastine not Vincristine, the latter is better with leukemias keep up the good work, following from Egypt :)
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I think you made a mistake on staging HL. Both side of diaphragm in stage 3 is above and below, not left and right based on spine.
You are so right ✅️ 👏
T as raison
I have seen his videos for too long and this is the first time i see him making such a mistake. Anyway we were able to catch it and could use the rest of the class
This is right btw, I got a question wrong on a test because of it 😭 (still love u ninja nerd)
he was keep saying diaphragm diaphragm diaphragm , didn't you all hear that ? he also writed "diaphragm " multiple times . you guys need to focus while studying . Good luck
This dude single handedly makes medicine easy for me
If there was no ninja nerd 1 would have dropped out longtime
You can say that again
I was diagnosed with HL last week. I’ve watched this 3 times, and it is so well done! I have a really good handle on what’s happening in my body thanks to this. Really educational stuff
6 years in remission over here. You're going to get through this, you wont know how you'll get through it, but you will. Good luck to you, you've got this
@@chloeclo7 thank you very much. PET results came this morning: stage 1A. About as good a starting place as could be… I mean as the video states any stage is curable, but the lesser the better
I was also diagnosed with this type of cancer during pandemic. Thankfully, I've fully recovered. Hope for your fast recovery!
@@Miyanazuki so far so good. 1 cycle of chemo so far with one to go. My neck lymph nodes are completely shrank down to normal looking at this point. I’m feeling good
I've been in remission for 9 years. Glad to hear you caught it early Daniel! Stay strong Brother
recently just finished my treatment for hodgkins lymphoma stage 2 and ever since i finished treatment i have been so incredibly curious of how it works, so thank you so much for this video!!
What was your treatment?
@@junefreeman7955 so essentially it was entirely chemo since radiotherapy was too dangerous long term due to the locations of my cancer, i initially had 2 courses of ABVD with no unexpected side effects, a pet scan after those courses showed that only a small amount of cancer remained and in turn i had 2 courses of BEACOPP with a PICC insertion, thankfully after that i was cancer free, fortunately i was just young enough to be in a children’s hospital (the food is immaculate)
My guy Zach here is making my hematology rotation so much easier. Thanks a lot bro
Do you have any suggestion where to watch surgery lectures?
Hello from Brazil , I just wanted to say that I really like your classes they are very detailed and very well explained , whenever I have to remember some basic concept I go back to one of your videos and suddenly everything makes sense , yours enthusiasm for teaching is contagious and on top of that you make it all available for free on youtube and on your website it seems almost too good to be true, and I just wanted to thank you and your team.
Thumbs up team!!!
Thought very necessary to add that the Ann Arbor staging got muddled along the way viz:
* ' On either side of the diaphragm ' refers to grom chest upwards and abdomen below as opposed to on either side of the chest.
"A single extra nodal involvement is still stage 1 in the absence of a lymphadenopathy .
I was looking for this comment
Nursing school student here, the deep dive really helps me understand and remember symptoms and treatments. Thank you!
I'm a physical therapist,so this is not even something i need to study but i started watching your videos a while ago and i just can't stop
Great video. The description of stage III CHL was stated correctly, but I think the drawing for stage III is slightly incorrect. While it includes both sides of the mid-line (which is shown in the diagram), it also includes both sides of the diaphragm, which was clearly stated, but not draw on the diagram.
Thank you
for using your gift of teaching!
I am the mother of a son Dx with stage 4 HL ...
recurrent.
This is probably the most advanced lecture i saw about Hodgkings. I really love the way you lecture,and with all the stuff writen and showned. I just wanted to tell you that you should add on this video about 5 minutes about radiation therapy in treating Hodgins. I am medical physicist and we radiate lot of patient with Hodgins, cervical , clavicular, axilary, mediastinum, and nodes bellow diaphragm. Keep doing i really loved your work
Perfect dear teacher you are an international teacher I follow your videos from Afghanistan .
Dear zach please rectify ann harbor staging , if H.L is present on both sides of diaphragm above and below not side by side it is stage 3 and if on same side it will be either stage one or two
That's not quite right. Just the neck (one side or both) is stage 1. Neck and chest is stage 2. Neck, chest and abdominal area is stage 3. Neck, chest, abdomin and groin is stage 4. Speaking as a stage 3 HL survivour
@@chloeclo7 Stage I:
involvement of single lymph node region or single extralymphatic site
Stage II:
involvement of two or more lymph node regions on same side of diaphragm; may include localized extralymphatic
Stage III: involvement of lymph node regions on both sides of the diaphragm; may include spleen (Ills) or localized
Stage IV: diffuse extralymphatic disease (e.g. in liver, bone marrow, lung, skin)
Hodgkin's Disease
great as always!! Just one observation: one side of diaphragm or both sides of diaphragm means above or below the diaphragm, not left or right.
much love to all of your team. but you especially zach have a special place in my heart.
65+ retired Parmacist here just keeping up. So much advanced biochemistry and pharmacokinetics here. Thanks so much. 😊
65+ retired Peds ER Doc. Watching this too! 👍
You have made a subject that can be so difficult to learn, so much easier. Thank you!
Don’t know what to say, more than that I am Sao impressed over your teachings skills. Keep it up! Regards from Sweden
I don't ever drink, and the main reason is that for a few years I experienced pain in the back of my head everytime I drank alcohol. Thanks to this video I now know why. Very common in people with HL
Fantastic
Very clear and pleasant way
But in staging in min 52 (both sides of diaphragm means above and below diaphragm not to the right or left ) thanks for the magnificent lecture
Just diagnosed with non Hodgkins lymphoma. So I'm watching this first and then the non Hodgkins video. I love how you explain with you drawings and knowledge. 2024. I'm getting monoclonal antibodies. Gazyva and Venclexta!! newest rx
Dear Dr. Zack,
I am very grateful for all your amazing videos. They are of a great help.
But Regarding the Staging of Hodgkins lymphoma, it is determined according to the presence of lymphadenopathy above or below the diaphragm. not the right or the left sides of the body
Stage I: Either of the following means that the HL is stage I:
HL is found in only 1 lymph node area or lymphoid organ such as the thymus (I).
The cancer is found only in 1 part of 1 organ outside the lymph system (IE).
Stage II: Either of the following means that the HL is stage II:
HL is found in 2 or more lymph node areas on the same side of (above or below) the diaphragm, which is the thin muscle beneath the lungs that separates the chest and abdomen (II).
The cancer extends locally from one lymph node area into a nearby organ (IIE).
Stage III: Either of the following means that the HL is stage III:
HL is found in lymph node areas on both sides of (above and below) the diaphragm (III).
HL is in lymph nodes above the diaphragm and in the spleen.
Stage IV: HL has spread widely into at least one organ outside of the lymph system, such as the liver, bone marrow, or lungs.
Thank You.
As a hodgkin's lymphoma survivor of 30+ years will be cool to see a deep dive into the mechanisms involved!
What's cool?? It's a disease
@@dustlessbard007 did you have Hodgkin's?
@@wsclesky chill bro. So you mean this video is perfect for seeing a deep dive into the mechanisms?
Glad You're alive!
Kindly help me in this disease bcoz my uncle has thi Hodgkin's lymphoma and we are worried that whether we should go for chemo we don't know what to do and uncle is becoming weaker n weaker day by day ...
Thanks Zack, consider doing an immunology playlist in your future plans, it will be awesome
You are the best
I smashed my seminar today all thanks to your notes prof.Zach
You are the best ninja nerd
The best way to teach medicine is your way👌🏻👌🏻👌🏻
Watching sir Ninja lecture exactly after three years.
Great lecture, really helpful - just provinding feedback regarding lymphoma staging - Stage 3 is both sides of the diaphragm whereas your illustration has an ipsilateral/contralateral depiction.
no words could ever express my gratitude for u , YHANK U ♥
❤❤❤❤❤ We can see the dedication of your loving parents through your emence knowledge and way of educating this world with your amazing presentations.
Love you little boy and your kind parents
Hello from India, your lecture are very helpful, thanks 🙏
Can i get the written note
Thank you for the great lecture, your lectures are totally useful for my hospital rotations, you're awesome!
For staging sides of diaphragm means -upper side from the diaphragm and lower side from diaphragm
THAT WAS REALLY IMPRESSIVE WAY OF TEACHING, AND KNOWLEGABLE
THANK YOU VERY MUCH
We all love this guy , its just what it is .
A Kenyan medical students. You really help me out
You have really really helped us so much by making it crystal clear, very easy to understand, very easy to memorise!! Thanks a tonn!!!❤❤❤
Thank you so much ❤this is exactly what I am going through mind boggling 4th doctor playing games with my life waiting for referral for treatment to oncology hematology
What a video. Thank you so much for this presentation. May God bless you
Bro is a legend for making these videos
May Allah bless you for this extraordinary lecture thank❤❤❤ you
Have been in remission 3 years now with hodgkin’s lymphoma. Pretty interesting to see how it all goes about within this video.
Congratulations on your current and continued remission status! - TG
amazing video! thank you from a pharmacy PGY2
Very well done. I am a trainee in radiation oncology and found this so useful!
This is soo supercool, the illustrations, the methodology the sync of the topic is bang on
so fun to read about the disease as a medical student which u were a patient of
Please make videos on other hematological diseases like multiple myeloma
these 'funny-looking' doodles actually pack more knowledge than what I've accummulated through my 2-month course
Great video, I was diagnosed with classical hodgkin lymphoma stage 2b.
Had 2x cycles of abvd but moved onto escalated beacopp-dac.
Had 4 cycles and got me into remission, but now having radiotherapy to the mediastinal.
Currently 6 sessions done and 9 left. Thanks for the video 😊
are you feelin better
@rociolahere6637 yes thanks i have completed all the treatments, and now I will be seen every 3 months for checkups and a blood test. It's been a hard 9 months, that's for sure.
Hi just after my first chemo shoot for Stage 1 classical Hodgkin's lymphoma multicellular. Looking for some understanding. Can only say finally found. Thank you.
Zack you're wonderful!!! this video make my information go high in Hodgkin's Lymphoma and that's because of your very good tutoring. best luck for you man.
I’m crazy about your videos! Thank you, each member of the team!!
god bless u doctor zac i hope every medical student gets to see your videos once in theyr years of studying . hyped to see non hodgkin lymphoma next 🙏
Thanks. Waiting for non hodgkin lymphoma.
Thanks a lot , your lessons are just amaizing and organised please continue
Love how detailed this is, have my radiation therapy board exam coming up, than you!!!!!
Please make a video about Osteonecrosis, it's causes and treatments.
Zach in my soul❤
THANK YOU.. such a huge effort
that's soooooooooooooooooooooooooooooo exceptional explanation , oh god you are a genius !!
Great presentation and structure
mashallah doctor I really appreciate what u do 💘✨✨
Great video
Makes understanding easier
Top notch as always
This guy z heaven sent💯
wonderful teacher
Amazing video. I hope they will ask about hodgkin’s lymphoma on exams for my English Language and Literature degree :)
Thank you for clear explanation and elaboration.
can we do a CBC to see if WBC increased? why do we go straight to biopsy
World class tutorial ❤️
You're simply amazing teaching, congrats, keet it up, from Brazil!
I hit the like button before I even start lol really I can’t thank you enough
And the way that you teach and simplify things is just amazing it makes me want to learn more
Thanks a lot 🙏
hello professor Zach, good job keep it up, my comment is on the staging " on both sides of the diaphragm" is to mean above and below the diaphragm, not right and left sides
Thank you P Zac. You're amazing❤️
My cousin has just been diagnosed with T cell rich B cell lymphoma
She originally went to her Dr 15 months ago with Autoimmune hemolytic anemia that was treated with Rituxinab and Prednizone.
After getting her Hemoglobin up within a normal range they attempted a sample from the bone marrow with no success and decided to wait and see how her response was.
About two months later anemia was back so they added a drug used in transplant patients along with more Rituxan infusions. They made note her spleen was enlarged but thought possibly due to Covid. ( she did contract Covid two weeks prior to this second bout with anemia)
She just continued to improve a bit only to have her hemoglobin dip, seemingly faster each time.
About 6 weeks ago she collapsed, they put her in the hospital and decided her spleen has to go. It was 5-7 times the normal size loaded with cancer.
She became very confused. Very anemic and on top of that they found hypercalcenia.
Her result of Bone marrow sample said 95% cancer. Not sure what they mean by that.
They’ve recently said she has T-cell rich Bcell lymphoma.
Help!! I’m guessing this is really bad!
Thanks Zach 🎉🎉
I just diagnosed my self,😢I think I need to see a doctor
this video is not in the hematology playlist! I love it though
This talk is so good, thank you for sharing!
loved this but isnt there a mistake for the ann arbor classification ?
like for stage III, both sides of the diaphragm means both under and above the diaphragm i think
50:44 i thought same side meant lymph nodes were grouped together superiorly vs inferiorly (as in the cutoff is the horizontal line that demarcates above vs below diaphragm) not left vs right (hemidiaphragm) can somone confirm?
yes, the classification shown in the video is wrong. If you do a google search of ann arbor classification (Lugano's revision) you'll find the right one.
Yes, absolutly right!
PLEASE POST MORE BIOCHEMISTRY AND MOLECULAR BIOLOGY RELATED VIDEOS ZACH, IT'S BEEN SOOO LONG.
Suggest a topic, it will be more easier for him then
hello , i am from india. lovely video . hats off .
I love your classes. Thank you 😊
I really think that both sides of the diaphram means above and below (not left and right)
In 10:31, shouldn't the B-cells be the ones that express the antigen on their MHC class 2 molecules, not the T-cell? And that the B-cell activate T-cells, and let them produce specific cytokines, such as IL-4 and IL-5, which will induce the class switching?
Thanks Zach.
In staging, we should consider lymph nodes up and down the diaphragm (not right and left), shouldn't we?
Correct. Good lecture, but I think the Ann Arbor staging was mistaken here. It’s based on whether the LNs or above/below the diaphragm, not based on which side of the body (left vs right).
Yes, caught that mistake as well. Otherwise spot on!
Thanks u made it very simple
Thank you for all the videos! They really help a lot!
really very grateful for the video 😇😇
iam from ethiopia ;you're legend
Amazing lecture prof 👏🏻
Really great presentation
I was waiting for this for long time😢😢😢
God bless you guys ❤
is this in honour of Hank Green? :)
No lol
Too much of a coincidence
Agreed
hey great video as always, i am a huge fan, depending on you in my medical years, but in the ABVD treatment the V stands for Vinblastine not Vincristine, the latter is better with leukemias
keep up the good work, following from Egypt :)
Please cover oncology😢,
including NHL, MDS ....
one video on pathophysiology of SIADH, types of SIADH, SIADH vs Cerebral salt wasting,
Please, it will be better if you put Hodgkin’s lymphoma in haematological diseases playlist