Great presentation. I was diagnosed with MZS Lymphoma, Stage IV (low grade) in 2005, only 5 years after retiring from the Army as a Aviator. I was 43. The one thing I think is very important for diagnosis is how my symptoms presented themselves. Dry cotton mouth, severe itching (mainly where my clothes touched my skin tightly), night sweats, periodic fevers with no infection, and very severe fatigue. I never contributed any one of them to be part of the collective issue. I like to think I’m educated and informed, but there was no way I could have connected them all to NHL. Even the doctors were baffled. I was admitted to the hospital, and for a week I was the Guinea pig for about a dozen residents. There’s nothing more concerning when it comes to my health then watching doctors scratch their heads and not have answers. It took a bone biopsy to find the truth. After my enlarged spleen was removed, I went through CHOP-R (I wouldn’t wish it on anyone), and maintenance treatment for 4 years. I’m still in the fight, and the key for patients is to stay aggressive and informed in your treatment. Including the PET scans and labs as often as possible. What you presented here really helped me understand the process of how it progressed. Thanks
Thanks for sharing your story. The cotton mouth is perhaps the first I've seen where listed on any stories of lymphoma symptoms but makes so much sense. I have a enlarged lymph node but haven't taken the order in to have the ultrasound yet. Waiting g for insurance to kick in. In the mean time I've been going batty with the dry mouth for about 3 weeks, lozenges don't even help and have been wondering whats going on.ive got the severe fatigue too so hanging onto my job by a thread. I hope I don't have lymphoma but answers would help ease my worries. The treatment for yours sounded harsh. Hope you're doing well now. 😊
Hi me too I'm a 63 yr gramma had the fatigue lost 50 lbs stressed the sweats had left marriage moved in w son & they had 2 babies bk to bk I was helping I became a live in baby sitter stressed fatigued 1st stages of non hodgkin's had no clue lived like tht 5 yrs came bk into marriage w regret forced to for severe financial / stressed related I was finally diagnosed in May this past spring of 2024 HOP been stage 3 diagnosed now I was told last week I'm complete Remission have only 2 chemo sessions left
One of the best lecture ever attended on Non Hodgkin Lymphoma ever attended or learnt in my life...too too good...no words to describe the marvellous way in which the concepts are given by the presenter...hats off to you sir
I live vicariously through you. Before I was struck by lightning, I tutored physics, chemistry and calculus. I discovered you exploring Hodgkins lymphoma as I have many symptoms and am trying to get referred to an oncologist. Your videos are amazing! I miss teaching so very much.
I have non-hodgkin mantle cell lymphoma. Going through RBAC chemo after 7 cycle of Retoximab and acalabrutinib. Not sure why RCHOP shows everywhere to tackle the cancer. Presentation was mind blowing, the best so far in YT. Thank you!!
Hi , Just wanted to spread the word that there are many families who have suffered with NHL due to carcinogenic product's and are entitled for a significant compensation , just let me know if you are intreasted to know more ..
Once again a huge THANK YOU Ninja Team💕 for all your hard work. Team work makes the dream work. All my love to you all. Happy midsummer from Finland 🇫🇮👋!
I had NO symptoms other than a almond sized lump in my neck. Thought it was an infection. 1 month turned into several lumps that started pressing on my windpipe. I was lucky I had a DR that LISTENED to me and took me seriously.
Excellent presentation. The only thing that I am not ok with is the classification of Ann Arbor: sides of the diaphragm means sub and supra diaphragm and not left to right of the body. Please correct that
@NinjaNerdOfficial please explain what you mean here 1:10:23 when you are discussing staging in relation to nodes being on the “same side of the diaphragm “ or “different sides of the diaphragm.” The diaphragm is drawn on your figures it splits the thoracic region from the abdominal region. But when you are explaining it in real time you draw a dotted line down the middle of the figure like a Sagittal section. For ex. Stage 3 is 2+ nodes on “different sides of the diaphragm,” but are you really trying to say it’s 2+ nodes on different sides of the mediastinum?
Great presentation. However for the staging ann arbor, different sources show lymphnode involvement for stage 2 on same side of diaphragm i.e above diaghram in chest upwards. If crosses below diaphragm, then stage 3. Not using sagittal plane as diaphragm reference. Kindly throw more light
Had severe EB mono in my 20’s. At 62 had DLBC lymphoma from taking Humira for 10yr. Crohns Disease. Remission 5 years. RCHOP and Methotrexate intrathecal
i was watch this awesome lecture from ninjanerd web page, had to come to youtube just to give BIG THUMBS UP.. what awesome way of teaching.. one little suggestion if ninja nerd team could rearrange the web page lecture's in order. thank you again
As always, you are the best! I appreciate your work and dedication. I'm a MD and I really enjoy and learn a lot from your video. I'd love to know you in person, that would be a huge PLUS! :D
Hey Zac. Thank you for the video, such a comprehensive and detailed explanation. But in 1:00:47 you mention that the translocation for Follicular Lymphoma is t(11;14), isn't that for marginal cell lymphoma (also Multiple Myeloma)?? You probably meant t(14;18) for Follicular? Please confirm. Thank you again!!
Zach , i really like your videos and you always make a very thorough analyse of the topic. Just a small correction about ann arbor stages II and III in hl and nhl . Stage 2 means 2 or more groups of lymph nodes affected either above or below the diaphragm and stage 3 means lymph nodes above and below (its not about left or right part of diaphragm)
Great videos! Absolute the best. Could you please add normal histology prep of the different NHL next to histopathology. It is difficult for me to know what to look at If I don’t have anything to relate to... Thank you for your interesting videos!
Had a swelling on the right side of neck appear almost overnight, and go away after two weeks or so. Also was noticing weight loss without trying. Months later, found a cancerous tonsil on the right side. Was found to be B-cell non Hodgkins. Determined I was at stage IIIA. Could chronic lung infection from maybe histoplasmosis have led to this? Had the upper right lobe removed. Now in the process of treatment.
Point out one mistake in 59minutes ,Histopathology of genetics u said Follicular Lymphoma from 11:14 translocation but its incorrect nasically its from 14:18 translocation
Hello doctor i have diagnosed with nhl t cell lymphoma i have got 2 times roung reports first one is squmas cell carcinoma and second one sarcoma both biopsy result are wrong taken 6 cycle chemo wrong after they did surgery inguinal and glutial region and removed my lympnode after the surgery report was came lymphoma stage 4 and they told 6 cycle chemo 4 cycles responded well after it relapsed bec of so many wrong drug taken previously again 3 cycles i have taken no use decease was so aggressive and they gived brentoximab it controlled well and they taken me to autologous transplant after transplant ater 3 months they gave me brentoximab 3 cycles for not to come back of decease but transplant after 6 months it came back they did biopsy and they r telling now before it was in blood now it came into skin And now they are giving vimblastine 10 ml for 8 weeks now 2 weeks over it was responding very well Will vimblastine cure completely in 8 weeks please tell sir ? Can i join college next month ?
Could the staging part can be wrong? You have drawn the diaphragm with the red as in correct position but describing an arbitrary midline which is wrong. Ann Arbor classification is based on according to the diaphragm. Thanks for the excellent videos.
Nice lesson. Just one correction: in the Ann Arbor staging system is considered if the lymphnodes are above or below the diaphragm, not in both sides of the body.
Great presentation. I was diagnosed with MZS Lymphoma, Stage IV (low grade) in 2005, only 5 years after retiring from the Army as a Aviator. I was 43. The one thing I think is very important for diagnosis is how my symptoms presented themselves. Dry cotton mouth, severe itching (mainly where my clothes touched my skin tightly), night sweats, periodic fevers with no infection, and very severe fatigue. I never contributed any one of them to be part of the collective issue. I like to think I’m educated and informed, but there was no way I could have connected them all to NHL. Even the doctors were baffled. I was admitted to the hospital, and for a week I was the Guinea pig for about a dozen residents. There’s nothing more concerning when it comes to my health then watching doctors scratch their heads and not have answers. It took a bone biopsy to find the truth. After my enlarged spleen was removed, I went through CHOP-R (I wouldn’t wish it on anyone), and maintenance treatment for 4 years. I’m still in the fight, and the key for patients is to stay aggressive and informed in your treatment. Including the PET scans and labs as often as possible. What you presented here really helped me understand the process of how it progressed. Thanks
Thanks for sharing your story. The cotton mouth is perhaps the first I've seen where listed on any stories of lymphoma symptoms but makes so much sense. I have a enlarged lymph node but haven't taken the order in to have the ultrasound yet. Waiting g for insurance to kick in. In the mean time I've been going batty with the dry mouth for about 3 weeks, lozenges don't even help and have been wondering whats going on.ive got the severe fatigue too so hanging onto my job by a thread. I hope I don't have lymphoma but answers would help ease my worries. The treatment for yours sounded harsh. Hope you're doing well now. 😊
Are you still fighting or you win I hope you are doing okey
Hi me too I'm a 63 yr gramma had the fatigue lost 50 lbs stressed the sweats had left marriage moved in w son & they had 2 babies bk to bk I was helping I became a live in baby sitter stressed fatigued 1st stages of non hodgkin's had no clue lived like tht 5 yrs came bk into marriage w regret forced to for severe financial / stressed related I was finally diagnosed in May this past spring of 2024 HOP been stage 3 diagnosed now I was told last week I'm complete Remission have only 2 chemo sessions left
CHOP THERAPY
@@janiceaguilar3593awesome!
Excellent. As an oncologist I can say that this lecture is so true and important for common understanding
Simply the best Professor of Medicine on World Wide Web.
One of the best lecture ever attended on Non Hodgkin Lymphoma ever attended or learnt in my life...too too good...no words to describe the marvellous way in which the concepts are given by the presenter...hats off to you sir
Best medical and physiology videos anywhere on the internet! Thank you for your dedication!
I live vicariously through you. Before I was struck by lightning, I tutored physics, chemistry and calculus. I discovered you exploring Hodgkins lymphoma as I have many symptoms and am trying to get referred to an oncologist.
Your videos are amazing! I miss teaching so very much.
Seriously the best comprehensive, detailed and yet effective explanation I’ve seen on the internet
Your dedication to sharing knowledge across the world is unbelievable, Thanks so much
I have non-hodgkin mantle cell lymphoma. Going through RBAC chemo after 7 cycle of Retoximab and acalabrutinib. Not sure why RCHOP shows everywhere to tackle the cancer. Presentation was mind blowing, the best so far in YT. Thank you!!
Hi , Just wanted to spread the word that there are many families who have suffered with NHL due to carcinogenic product's and are entitled for a significant compensation , just let me know if you are intreasted to know more ..
Thank you .. This video is on time for my last semester in medical school ...having Hematology in a month! ... This surely made everything way easier
Once again a huge THANK YOU Ninja Team💕 for all your hard work. Team work makes the dream work. All my love to you all. Happy midsummer from Finland 🇫🇮👋!
I’m so glad you are making haematology videos because I have an exam in a week and these are the only thing that makes sense to me. Thank you !!!!
This should be paid. THANK YOU SO MUCH
I was diagnosed with hodgkins lymphoma a year ago my chemo is complete and excited to study the hodgkin and non hodgkin as a med student
Absolutely the best explanation I have ever received on this topic,even paid platforms fail to give such detailed and understandable explanation ❤
1:00:46 Correction = " Follicular cell lymphoma " is associated with chromosomal segment translocation between chromosomes 18 & 14 ; t(14,18) NOT chromosomes 11 & 14 ; t(11,14) .
Correction: It is t(14;18) not t(18;14)
Thank God for Dr. Zach!! 🙏🏼❤
I had NO symptoms other than a almond sized lump in my neck. Thought it was an infection. 1 month turned into several lumps that started pressing on my windpipe. I was lucky I had a DR that LISTENED to me and took me seriously.
Genius . saved my time instead of cluelessly staring at the text books
Excellent presentation. The only thing that I am not ok with is the classification of Ann Arbor: sides of the diaphragm means sub and supra diaphragm and not left to right of the body. Please correct that
Greetings from Colombia. Your presentation skills are A+.
I am 1yr in remission from diffuse large B cell lymphoma. Thank you for helping me understand my disease.
@1Alchemist420I was stage 2E. Did 3 cycles of R-CHOP chemotherapy followed by 21 treatments of radiation.
Thanks a lot! Excellent presentation! Zack, you have a natural uncanny set of skills to teach!!!
Okay but ninja nerd uli chi pondo..👌 From a mad scientist to a Ninja nerd. I salute
Zambia ku caalo😂... I just had to like your comment
Thank you very much, great explanation from start to finish.
You first talk about physiopathology and until you finish to treatment. We are grateful.
Thanks for this content I don't realize this much in class❤
@NinjaNerdOfficial please explain what you mean here 1:10:23 when you are discussing staging in relation to nodes being on the “same side of the diaphragm “ or “different sides of the diaphragm.” The diaphragm is drawn on your figures it splits the thoracic region from the abdominal region. But when you are explaining it in real time you draw a dotted line down the middle of the figure like a Sagittal section. For ex. Stage 3 is 2+ nodes on “different sides of the diaphragm,” but are you really trying to say it’s 2+ nodes on different sides of the mediastinum?
It should be above/bellow
Im literally only passing my exam because of your videos. Forever grateful ❤
Love your presentations. They are very informative and helpful. Thank you
Tnx professor Zach you are the best teacher I've ever seen❤❤❤❤❤❤❤❤❤
I have been waiting for this lecture. Thank you sir!
Excellent presentation
Excellent excellent excellent....world great top teacher you are sir...keep it up..God bless you
THANK YOU and THE TEAM behind this channel ❤❤
You really are a great teacher! ❤️
Great presentation. However for the staging ann arbor, different sources show lymphnode involvement for stage 2 on same side of diaphragm i.e above diaghram in chest upwards.
If crosses below diaphragm, then stage 3. Not using sagittal plane as diaphragm reference. Kindly throw more light
Had severe EB mono in my 20’s. At 62 had DLBC lymphoma from taking Humira for 10yr. Crohns Disease. Remission 5 years. RCHOP and Methotrexate intrathecal
Biologics can kill. I was on Remicade for nine years, it gave me NHL. It wasn’t worth it.
I am overflowing with knowledge 🧐
Love this stuff, please do some more!!
Huge respect for u guys❤
Thanks a lot Professor Zac from 🇿🇲🇿🇲🙏
Amazing presentation❤
Awesome presentation- thank you
i was watch this awesome lecture from ninjanerd web page, had to come to youtube just to give BIG THUMBS UP.. what awesome way of teaching.. one little suggestion if ninja nerd team could rearrange the web page lecture's in order. thank you again
best medical videos at all
Brilliantly explained & presented! Thank you!
Can’t thank you enough Dr.Zach😊
Perfect presentation…very inspiring….Great instructor
A BIG THANK YOU FROM UGANDA.
Wow, you're an amazing teacher.. Thank you so much for doing this... Now, I can talk to my doctor and know more what he's talking about. 🙏
Uploaded right after my hematology exam😭 passed though thanks to the other hematology videos🙏
Your lectures are too good
thank you Zac,very informative
I have been looking for this after watching Hodgkin lymphoma
Where’s the Hodgkin videos pls
Amazing lecture! Thank you very much for your dedication
Rockstar! Very informative and I didn’t die of boredom!
Thank you so much for your lectures on Hodgkin’s and non-Hodgkin’s lymphoma! Learned so much. Can you talk about HLH next?
At 1:00:55 you made a mistake the follicular cell lymphoma is a mutation in 14;18
Thank you for your dedication!
Thanks Mr Zac ❤❤
Superb lecture 😊
As always, you are the best! I appreciate your work and dedication. I'm a MD and I really enjoy and learn a lot from your video. I'd love to know you in person, that would be a huge PLUS! :D
Great video. Just a little addition; P53 will suppress proliferation so the mutation in cancers inhibits p53 (like in diffuse B-cell lymphoma)
And we had this same lecture in class a day ago. Coincidence!!
Perfect as always ❤
Absolutely amazing 🤩😍😍
Hey Zac. Thank you for the video, such a comprehensive and detailed explanation.
But in 1:00:47 you mention that the translocation for Follicular Lymphoma is t(11;14), isn't that for marginal cell lymphoma (also Multiple Myeloma)?? You probably meant t(14;18) for Follicular?
Please confirm. Thank you again!!
You are really awesome , great lecture ..Multipl Myeloma please 🙏only you can do it properly and perfectly
Colon cancer
Breast cancer
Ebola virus
Sir these all topics are very important, please make a video on these topics
Thank you sir
I love your video so much, thank you for giving us such useful information
Excelent video you really helped to me as a med student
amazing as always
Thank you for explaining!!! I'm doing Gazyva infusions and Venclexta tablets Monoclonal Antibodies are a real game changer!!!!!
Amazing!!!!!!!!! Loveee it!!!! Thankyou so much, you're extremely good mentor
You are awesome!!! Thank you so much! 😊❤
Thank you for the hard work
Zach , i really like your videos and you always make a very thorough analyse of the topic. Just a small correction about ann arbor stages II and III in hl and nhl . Stage 2 means 2 or more groups of lymph nodes affected either above or below the diaphragm and stage 3 means lymph nodes above and below (its not about left or right part of diaphragm)
Great videos! Absolute the best. Could you please add normal histology prep of the different NHL next to histopathology. It is difficult for me to know what to look at If I don’t have anything to relate to... Thank you for your interesting videos!
Amazing lecture.
Had a swelling on the right side of neck appear almost overnight, and go away after two weeks or so. Also was noticing weight loss without trying. Months later, found a cancerous tonsil on the right side. Was found to be B-cell non Hodgkins. Determined I was at stage IIIA. Could chronic lung infection from maybe histoplasmosis have led to this? Had the upper right lobe removed. Now in the process of treatment.
How's treatment going?
@@catherineero1317 Just a year out from last chemo, and still in remission as far as I can tell.
Great as always
Thank you
سپاس فراوان
thanks for this class❤❤❤❤❤
Point out one mistake in 59minutes ,Histopathology of genetics u said Follicular Lymphoma from 11:14 translocation but its incorrect nasically its from 14:18 translocation
Great video, as always. Thanks!
Thank you sir 😊😊
Wow. Thank you so much, so much to learn.
Hello doctor i have diagnosed with nhl t cell lymphoma i have got 2 times roung reports first one is squmas cell carcinoma and second one sarcoma both biopsy result are wrong taken 6 cycle chemo wrong after they did surgery inguinal and glutial region and removed my lympnode after the surgery report was came lymphoma stage 4 and they told 6 cycle chemo 4 cycles responded well after it relapsed bec of so many wrong drug taken previously again 3 cycles i have taken no use decease was so aggressive and they gived brentoximab it controlled well and they taken me to autologous transplant after transplant ater 3 months they gave me brentoximab 3 cycles for not to come back of decease but transplant after 6
months it came back they did biopsy and they r telling now before it was in blood now it came into skin
And now they are giving vimblastine 10 ml for 8 weeks now 2 weeks over
it was responding very well
Will vimblastine cure completely in 8 weeks please tell sir ?
Can i join college next month ?
great lecture ..thank you
very well explained
Thanks from India 👍
Could the staging part can be wrong? You have drawn the diaphragm with the red as in correct position but describing an arbitrary midline which is wrong. Ann Arbor classification is based on according to the diaphragm. Thanks for the excellent videos.
Great work,,,, Very easy to retain now,,,
Do mantle cells and marginal zone cells occupy the same space?
u r great abd dedicated teacher. thank you
Could we get a video on multiple myeloma?
Thanks dear Prof, Please explain GIST
Amazing sir !!!
Ninja nerd ❤forever❤
Nice lesson. Just one correction: in the Ann Arbor staging system is considered if the lymphnodes are above or below the diaphragm, not in both sides of the body.
Too bad I cant just pay you instead of my university....
Thanks for all you DO🙌🙌. Zach! A video on Renal tumours won’t be a bad idea🙂