Chronic Lymphocytic Leukemia (CLL)
ฝัง
- เผยแพร่เมื่อ 28 มิ.ย. 2024
- Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/chr...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Chronic Lymphocytic Leukemia (CLL). CLL is a type of cancer that affects the blood and the bone marrow. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Chronic Lymphocytic Leukemia (CLL) Introduction
0:55 Hematopoiesis Pathway
5:36 Pathophysiology
17:49 Diagnostic Approach to CLL
26:27 Treatment
33:49 Comment, Like, SUBSCRIBE!
Join this channel to get access to perks:
/ @ninjanerdofficial
APPAREL |
shop.ninjanerd.org
www.amazon.com/s?k=ninja+nerd...
PODCAST |
Apple Podcast: podcasts.apple.com/us/podcast...
Spotify: open.spotify.com/show/2ZDXoak...
Google Podcast: podcasts.google.com/feed/aHR0...
DONATE
PAYPAL | www.paypal.com/paypalme/ninja...
SOCIAL MEDIA
FACEBOOK | / ninjanerdlectures
INSTAGRAM | / ninjanerdlectures
TWITTER | / ninjanerdsci
@NinjaNerdSci
DISCORD | / discord
#ninjanerd #ChronicLymphocyticLeukemia #leukemia
You really know your stuff. I have CLL apparantly coming out of a 4 year remission. I can't say I understand it all but pretty well for an IT person. I'm now 66 years old, i quit chemo halfway through because I got bad sepsis and was hospitalized a week or so for that. I had been also getting 2 units of blood packed with red blood cells weekly. It only lasted 5 days or so, finallly, my dr. prescribed me cyclosporin (Modified) 50 3xaday and within 2 days, my body stopped shortening the life of the transfusions and I went into remission. I was at NYC Mt Sinai let's see what happens now...The adventure continues!... thank you.
The love of my life got CLL as the result of exposure to Agent Orange when he was serving on two different Navy aircraft carriers during the Vietnam War. We lost him in February of 2023, after cancer took his bladder and prostate (not uncommon for CLL patients), as well as multiple skin cancers - all going on in his body at the same time. If you or someone you love has CLL, don’t postpone treatment. And God bless you.
That’s what my mom has, she got diagnosed with it on April 1, 2015. She waited treatment wise until January of 2021. She ended up doing immunotherapy for 5 months back in April of 2021. After her last treatment, she now has follow ups monthly to as of right now once every three months. She takes ibrutinib everyday along with acyclovir twice a day for shingles and celebrex for arthritis in her knees
How old is your mom , since my dad got diagnosed these past week
@@greedysourceofgod4819 young, mid 50s
You aren’t made to wait for treatment, a lot of times at the time your diagnosed there maybe no need for any kind of treatment right away unless something is going on where the cancer isn’t active per say and, that’s why your mom didn’t do or receive treatment till 2021! Example, I was diagnosed with CLL at the age of 42, however, I didn’t need treatment till 3 yrs later and, it wasn’t for the fact, I had to wait a certain period before, I got treated, the cancer was not active or rather nothing was going on till then, that required a reason to get any treatment!
She must be one strong woman. My husband was put on Ibrutinib and it put him in the hospital for nine days. They had to change to Calquence, and he did better on that.
@@sonyafox3271that's what she meant. She waited for treatment because the stage of the cancer wasn't yet at the point of treatment. It is not about being active..but stages of development as clearly explained in the video. Stage 0 you do nothing. Just wait... Etc etc
If I had teachers like you, I might have gone to med school. I recently learned that my wife has CLL. Even though I'm not in the medical field, I want to learn everything I can about her condition and your talks are absolutely amazing! One of the worst things of a disease is the unknown, and you have done so much to help me understand her situation. Thank you, thank you, thank you.
Yes, very good instructor. Just got my diagnosis yesterday. Will be looking for lots of information. Good luck go wife.
Grateful for you! Relearning, refreshing and enlightening!🙏🏻
you already helped me in physiology and now a few years later in clinical oncology. you're the best
You are so amazing!! I cannot stop bragging about your lectures to all my med student friends. ❤
Have had CLL but never had it really explained to me. Now I have a much greater understanding. Thank you.
Thanks for your supporting❤❤❤❤
i'm a biomed. student and these videos really help me understand hematology better
Tons of thanks for such an outstanding tutorial
I appreciate all the efforts you have done for these incredible whiteboards..
Amazing explanation, I really appreciated your countless effort to bring this high quality education for free.
You are the best doctor worldwide
❤brilliantly presented lecture, so helpful and easy to follow, thank you guys x❤
Yay 🎉🎉 I’ve been waiting for CLL thank you ❤
thank you so much really appreciate all the work you put into these lectures 💐💐💐
I was just diagnosed with CLL. (Feb. 2024) I am not symptomatic yet and will be living near MD Anderson in Texas. Should I consider a clinical trial for CLL? I am relatively young (not yet 65 yrs old) Thank you for all you do! God Bless!
Just been diagnosed with CLL so I'm just trying to understand it thank you
Please do us myeloproliferative neoplasms
u said "please" so sincerely that i liked the video before watching eyes teared
Best video on CLL ever!
Every word will not be enough to thanks you right
Thanks for every thing that you do here
Your effort will not ever fogetten ❤
Wonderful incredible outstanding idea of coming up with such TH-cam channel. Millions and probably more than that support your channel and they say between them that it’s helpful even though they don’t comment here. Keep up with this job. Your channel is no. 1 ranked in my opinion.
Love this! I'm learning so much.
I really dunno how to thank you, ur such an angel God sent to us , thank u so much for posting ur videos and these amazing info for free, ur amazing bro , love ya ❤!
Thank you, so proud of you 👏 🙌
Sir u are really a diamond of the medical science ...loves u a lot ....keep supporting us sir we need ur help❤❤❤
love how well you explain these complex concepts! this lecture really helped me with my research paper. keep being amazing! how do you know so much about so much?
Amazing content.Basics explained very nicely.
Wow keep uploading thanks 😊
These are great lectures; so helpful
Good job Prof Zach
Thank you a lottt! What a great channel.
Great info, great teacher🙌
our great teacher thank you
Brilliant well presented thank you.
Thank you for this presentation, God bless you 🙏
Thank you! Love your videos.
Thank you for this most informative video!!!
Thank you 😊
Thank You🙌🏽
Thank you very very much
You're the best, you helped in pathology
Thank you❤️
Thank you for your hard work ❤❤
thank you for your supporting us please we need explanation about chronic myelogenous leukemia ❤❤❤
Perfection as always
Thank you so much
Great overview of CLL! For the pathogenesis: it is true that we are not sure about the origin of the CLL, but scientific community agrees that some mutations on key genes are involved in the genesis of this malignant disease (familial CLL is also occuring in a small % of the population, and investigation is ongoing to try to find the correlation of certain genetic makeup with the CLL appearence). Importantly, we know for sure, based on preclinical studies to which I also contribute to, that the B-cell receptor signaling (BCR) is playing a role in the pathogenesis and progression of CLL.
Thank you for the video really appreciate it, I tried reading Davidson but didn’t understand
I have atypical CLL with multiple paraneoplastic syndromes starting with a massive Pulmonary Embolism with cor pulmonale in 2108 spent a week in the ICU. Most of my paraneoplastic syndromes have been neurologic. I have found that oncologists seem to know very little about paraneoplastic syndromes and just ignore my symptoms. I never get any answers and have to research everything myself. I delt with almost a year of appendicitis level lower abdominal pain with no help or answers. It seemed to be a vascular type pain which fit angioedema in my colon which is occassionaly seen with CLL. I have seen peripheral angiodema in the past and the pain was identical to what my patients complained of. I am trying to figure out how to get oncologists to listen, or find an oncologist who knows atypical CLL.
I am looking for help and get none. I also get no answers, which is very frustrating. I have to research everything myself to get answers. My oncologists don't even try. It is extremely frustrating! I have had to find treatments on my own with no help from oncologists.
ur awesome, i am a hematology fellow and the ASH SAP is complicated i need someone to simplify it for me so thank you for that really
thank you very much doctor
Amazing! Tyssm Zach
You are brilliant!
thank you for the video!!
Thank you so much 🙏❤
Thank you very much ❤
thank you zach
thank you for fabulous lesson. Your lecture is indispensable for me
Thank you so much 😊
Thank you so much ❤❤❤❤❤❤
am from africa , ghana your videos help me alot
Thank you for the video
amazing video as always
Maybe i'm wrong but you look under the weather in this video. Hope you are doing well. You are an incredible teacher! God bless you!! Prayers your way!
THANKS A LOT 🫶🫶🫶🫶🫶
Please make a video on tissue it's really helpful for me and many other medical students. It's a humble request Zach 🥺
Thanks so much sir
The best videos on Leukemia's😊
Thank you so much Zack you are the best
❤
Thank you for this videoo!
Please do an overview video on leukemias and lymphomas.
Thank you !
You are an absolute legend ❤️
Thank you so much sir…….
thanks Dr
Thank u ninja You're the best bcz of u I wanna be neurologist ❤
Justo lo que estoy estudiando ahora ❤❤❤
Your video was really informative, but... chemo is on it's way out for all cll treatment since ibrutinib came on the scene. When was this video made? And no mention of high risk cll subset (p17 del, tp 53 mutation) which renders chemo ineffective.
Brilliant
Thank you
Thanks
THANK YOU ❤❤
Watching from Nairobi, Kenya. Nice video prof, am gaining a lot from you and now it's almost 5yrs since I started your lessons. Ninja Nerd...... please give us certificates 😂😂 and we pay for it.
Very Useful Bravooo your soo Good ❤️❤️
谢谢您！🌸
thank you!
A legend indeed
RN here recently diagnosed with CLL/SLL under investigation for large B cell lymphoma, need a FISH study(you didn’t mention)
Now I know Im Rai 2 symptomatic with the typical B symptoms. Recent 50 lbs weight loss in 6 mths, lots of abdominal symptoms and pain.
FYI My other presenting initial symptom was thoracic back pain spinal cord compression along with the lymphocytosis . Thats a big problem. Knowledge is power!
Fantastic lecture Im gonna send it to my GP😂❤Thank you!!
@maggieensley8819 your story sounds like mine. I have had a weird rash for 1.5 years. It was called psoriasis, but nothing helps. Now it's on my back. Recently got intracellular nutrient test back and shows anemic. I've struggled with fatigue. So, next step is bloodwork. Has anyone experienced rashes? I am in my early 60's.
Love you Doc😘
LOVE!!! thanks
Commenting to support
AMAZING!!!
شكراً ❤
I have to watch this 10 more times to get it all down, but my mom was just diagnosed at 74. We meet with her med team tomorrow. Ill have lots of questions for them because of the knowledge in this video. Im armed and ready to fight! (With knowledge) xxoo thank you to the creator of this video.
I love this man
You teach better than my lecturer
You said please twice. So here I am.
and I get to say a big thank you!
Great videos my friend