What is the Cori Cycle? | Gluconeogenesis Explained Simply
ฝัง
- เผยแพร่เมื่อ 9 มิ.ย. 2024
- The Cori Cycle is one way that the body can metabolize lactate into glucose.
This is one metabolic pathway of gluconeogenesis (Creating New Glucose) that is done in the liver.
*The muscles can also do gluconeogenesis directly in the muscle cell (Especially type 1 fibers)
Lactate is the end product of anaerobic glycolysis. (Watch my bioenergetics video for more info about this! • Bioenergetics Explaine... )
In the cori cycle, lactate is transported through the bloodstream, into the liver and converted to pyruvate then glucose.
Additional Questions:
1: How quickly is lactate cleared?
Lactate is typically back to a resting concentration within 1 hour post exercise. This time is faster when an active cool down is utilized.
2: What goes through gluconeogenesis?
In addition to lactate, glycerol (after lipolysis), and amino acids can go through gluconeogenesis to be used for energy.
3: What hormones are involved in gluconeogenesis?
Glucagon, Cortisol, Catecholamines (Epinephrine/ Norepinephrine), Thyroid Hormone, and Growth Hormone.
4: What does the liver do?
In addition to the cori cycle, the liver breaks down glycogen polymers into glucose as well as plays a role in metabolism and storage of many nutrients. It also plays an important role in excretion of cholesterol, hormones, and drugs.
Studying for the CSCS Exam?
CSCS Prep Course: www.themovementsystem.com/str...
This is the CSCS Practice Test that I recommend: www.themovementsystem.com/off...
👇🏽Click here to Join the Strength and Conditioning Study Group on Facebook!
/ 2415992685342170
00:20 Path of Blood Glucose
01:40 Path of Pyruvate
02:00 Cori cycle
02:30 What is Gluconeogenesis?
03:05 Is this the only way to clear lactate?
03:25 How long does it take to clear lactate?
03:45 What else goes through gluconeogenesis?
04:00 How does this interact with the endocrine system?
04:37 Why is the liver important?
Make sure you check out some of the other CSCS Prep Videos I have done:
CSCS Nutrition: • CSCS Nutrition Calcula...
CSCS Work to Rest Ratios: • NSCA CSCS Work to Rest...
Muscle Levers: • Muscle Levers 1st Clas...
Olympic Lifting Technique: • Olympic Lifting Techni...
Comment below if you have any questions!
🧠 Learn more at www.themovementsystem.com
This is the CSCS Practice Test that I recommend: www.themovementsystem.com/off...
Disclaimer: This video does not have any affiliation with, or any recognition, sponsorship, or endorsement by, the NSCA. CSCS® and Certified Strength and Conditioning Specialist® are registered trademarks of the National Strength and Conditioning Association.
✅ Let’s Connect:
📱 Instagram: @themovementsystem
![Yoshi Rinrada - 'มาทำไม' [Official MV]](http://i.ytimg.com/vi/r41xbfRLkLs/mqdefault.jpg)
Follow along on Instagram to learn more: instagram.com/themovementsystem/
Yeah, you’re great, Matt, I trying to understand if I can bodybuild and do keto. I know nothing and your making me feel very clever as I learn from you!
Bro not even my lecturers at med school explain it as clear as you do. Thank you!!
Thank you!
From which country are you? We study this in 11th grade
I have a masters degree in ex physiology and have never had a professor explain this as clearly as you 🙌🏻💪🏻👍🏻
Thank you!
Helped me understand the concept easily and clearly,thanks man
I really appreciate how you think of including questions we might have and how certain concepts can be applied to clients. This all really helps with the overall picture.
Thanks for the kind comment!
TH-camrs always explain things so clearly and quickly haha, one of the best ways to study. Thank you.
I appreciate that
Nice explanation sending love from India ❤
Appreciate it! Sending love back from the USA❤️
This is SIMPLE and STRAIGHTFORWARD. THANK YOU!
such a great yet simple explanation, thank you for this!
You're welcome!
Loved the diagram!! Made it so much simpler
You made this very easy to understand.
This was explained pretty well. Thanks !
I've been a gym rat since I was 10 years old, 1975. I retired at age 53 due to extreme metabolic fatigue but learned to hack several of my genetic SNPs. I was so successful that I dropped below 10% bodyfat and gained more muscle. I was on the way to physique competitions when things started going South. One of the things that happened was that I would get extreme muscle soreness from workouts that wouldn't normally cause me to get sore. I also became more and more fatigued. I believe now, that I have it figured out. I believe that I have a Thiamine deficiency. I think this is causing two things. Since Alpha Ketoglutarate Dehydrogenase (Thiamine Dependant) is the rate limiting enzyme to the TCA cycle, my Oxidative Phosphorilation is being inhibited. Also, Pyruvate Dehydrogenase (Thiamine Dependant) is causing Pyruvate to build up, leading to increased Lactic Acid Fermentation. Do you agree with this possibility? I have many more symptoms that aligin with Thiamine Deficiency. I just want to know if my reasoning makes sense.
appreciate the nice drawings. Helps me visualise better! keep the content coming Matt!
Thanks! We work really hard to make simple easy to understand visuals. Glad they are helpful
after 10 years of trying to learn this. I finally get it.
Keep up the great content man so much valuable info in such a short video🙏
Thank you!
This helped ALOT ! simple yet effective explanation , thanks . Happily subscribed.
Thanks!
So incredibly helpful, thank you!!
You’re welcome!
Thanks, that diagram was so good , I will definitely add it in my notes , Love from India✨♥️
AMAZING EXPLANATION!!!
Thanks!
Thank you!! This is a great explanation.
You’re welcome
thank you! you are awesome, keep coming with great content
Thanks!
Thank you!! Making easier my PT certification, tons of help!!
You’re welcome!
great video!
I really enjoyed this interesting easy to understand video sir! \
SO WELL DONE!! Wish i had you when I was studying biochem in college!
Thanks!
I am in great shape from hill repeat bicycling with weight loss, increased muscle tone, increased endurance, increased performance/speed, and BMI dropped from 25 to 22.8 in a year. It seems like hill repeat cycling (with its high levels of mixed aerobic/anaerobic energy expenditure and cyclical recovery/lactate clearance) might be the best way to trigger the Cori cycle AND trigger mitochondrial biogenesis.
That is AMAZING thank you so much!
Glad it was helpful for you👍🏼
Nice video ! Very helpfull 😁👍
You're welcome!
You're very good Sir, Thanks
Thank you!
I love u, this was really helpful
💛
You are AMAZING!!!!!!!!!!!!!!
Thanks!
Great 👍 one
Thank you!
Hey Matt,
Feel like I'm always asking you questions haha.
When Lactate releases the Hydrogen ion to become Pyruvate, does this increase acidity of the liver?
Thanks for your work man!
Great video! Can you explain how lactate is metabolized by type 1 fibers to produce ATP?
The lactate dehydrogenase enzyme turns lactate back into pyruvate then the mitochondria rich environment of the type 1 fiber allows for oxidation through the Krebs cycle
Can you explain the citric acid cycle
Can too much protein in a type 2 diabetic cause this cycle ? I’ve noticed higher Protein keto diet keeping blood sugars high and can’t figure out why ?
At 1.56 how do we get lactate?
Does the Cori cycle get more efficient or "turn on" faster with long term training?
What happens, what does acetly-coA do after being converted from Pyruvate?
Goes to the Krebs cycle! I actually made a video on that:
th-cam.com/video/3Unl69yHiEk/w-d-xo.html
From which country are you guys and in which grade are you studying about Cori cycle?
i have a question, why cori cycle is always happen even we are not doing exercise?
Because there's always some amount of lactate production. It's just that with exercise lactate production can exceed the ability to clear it.
Can cori cycle result in liver glycogen formation?
I guess yes , I had same doubt but in my notes it's written that after going into liver lactic acid converts into glycogen
Why does gluconeogenesis is important in the Cori cycle?
According to studies done by Jeff Volek & Stephen Phinney, this process can upregulate substantially after a prolonged period of Carbohydrate scarcity or nutritional ketosis. I would LOVE to see a video from you breaking down your thoughts on the following lecture:
th-cam.com/video/BeS_dhM8dsY/w-d-xo.html
Dr. Volek does great work. I've spoken to him a number of times and attended a few of his lectures in person. I'm not a nutrition expert so I will have to do a fair bit of research to put together a video about ketogenic diets and ketosis but I'll put it on my future videos list.
@@TheMovementSystem Wow thats awesome! Volek is one of my biggest inspirations the past two years, I own both of his books he wrote alongside Stephen Phinney as well as the book they wrote with doctor westman. I see a lot of exercise science authorities "debunking" ketogenic diets, especially for athletes because they seem to believe the body just stops producing glucose or refueling glycogen when exogenous carbohydrates are cut from the diet. They completely leave out the Cori Cycle, and don't seem to be aware that glycerol and free fatty acids can also contribute to endogenous glucose and glycogen supply in the absence of exogenous Carbohydrate. I really want to hear someone like yourself who understands physiology on a deep level and is at least familiar with the work of ketogenic pioneers like Volek, discuss glycogen supply and demand in keto-adapted athletes. Specifically, do you believe there can be severe limitations on athletic performance in a keto-adapted state for heavily glycolitic sports such as BJJ or MMA? How exactly would converting lactate & glycerol be different than utilizing exogenous glucose directly? Does the cori cycle and gluconeogenesis just take more time to produce glucose/atp? Or do you think after long term keto-adaptation its possible that gluconeogenesis could be enough to sustain Performance?