I was a cardiac nurse but left the profession for twelve years and I am taking a refresher course to regain my license! Unfortunately just reading textbook doesn't work, thank you so very much for your help in getting another nurse, me!, back to what I love..my patients and caring for them! I am blown away by your videos! Again can't say enough, ty ty THANK YOU! I am recommending you to my course director!
I literally want to cry from happiness because YOU HAVE EXPLAINED IT ABSOLUTELY BRILLIANTLY and I am so glad I understand it now! THANK YOU THANK YOU THANK YOU
His name is Zach Murphy. He is a PA. he was tutoring ppl on science and such and he decided to dev this Chanel to help ppl like you and me trying to understand w/o pulling our hairs out
Every time I watch ninja nerd it makes me sad that I haven't watched more ninja nerd sooner. Everything clicks! You are literally the best teacher ever!
as much as Zach and the team blow my mind with how well they're able to explain these concepts, it's still amazing researchers were even able to work all this out in the first place
That was intense !!! Like a good movie ! You take the time to develop each protagonist and each time a new one comes it adds suspense and interest. The end of this video... JUST EPIC ! the paradox being resolved and the synopsis for the part 2 ! Brilliant !
Your explanation was the best, and I've seen Khanacadamy and other big names where they used a chart-like explanation. Yours was exceptional. Thank you!
Watching this, after my mom succumbed last month to complications from this disease, really hits hard. Softens the blow a bit, to understand the process more. Heartbreaking and hideous disease process💔
WHERE AND THE HELL WERE YOU, WHEN WE WERE IN MEDICAL SCHOOL. ONE OF THE PREMIUM TEACHERS OF SO MANY DIFFERENT TOPICS. LOVE HOW YOU GROUNDED THE MAJOR STRUCTURES EARLY IN VIDEO, BY FAR ONE OF THE BEST
this was really really amazing explanation! i watched many videos before this one and i also read this part from dipiro book and they weren’t enough for me to understand the whole thing!! THANKS A LOT ❤️ honestly, you’re the best teacher i have ever known
Perfect summary! maybe rename this video to Basal Ganglion overview or something because it took me forever to come across this gold! Thanks for This vid!
This video was exceptional! Thank you very much! Can you please do a video for multiple sclerosis like the ones for PD? It would really help...thank you!!
You are a very good teacher... I've a request...can you just speak a little slower it's difficult for me to get you some times ... other wise I have a great respect for you sir
Not Just Parkinson's Most the Neurodegenerative disease can be controlled through Ayurveda Treatment I have been to VIAMS, an Ayurveda Hospital in Kerala, India Their approach is integrated Ayurveda with Physiotherapy, Psychology, Dietetics and Speech Therapy Find Them Dr. K.V. VIJAYAN INSTITUTE OF AYURVEDA MEDICAL SCIENCE PVT. LTD. Mezhathur P.O. Palakkad, Kerala, India - 679534 India Toll Free : 1800 123 00 2442 Direct : +91 9846362442 : + 91 466 2270142 Email : info@viams.in www.viams.in
as always, great for my med studies...confused, when you want a strong contraction of biceps you increase the signal to its corresponding cortex area, but at the same time you increase the signal to the corresponding triceps area, which as a result contract as well, which works against the movement of the arm.
Dr Noah holistic healing herbal medicine is the best to treat Parkinson disease, i have been batheling this deadly disease for years now knowing full well my days are numbered. My Doctor prescribed some medication for me (Levodopa) which I was taking to help subdue the disease, at a point I was off my meds and the disease started to kick in. I decided to do research for an alternative cure which leads me to a blog where a patient was testifying about Dr Noah herbs, i was overwhelmed and ought to give it a try. To my greatest surprise i am free from parkinson with no much talk get in touch with Dr Noah via: Email: dr.noahmedicalcenter@gmail.com Call +1 310 982-4670 Visit website: noahmedicalcentre.webs.com/
👍🏼👍🏼 I am a Pk patient . 🤔Too much info for my brain to process and retain 🤯🗣But your presentation is amazing 👏🏽👏🏽and also good source of reference that I will frequently go back to👏🏽. 👍🏼👍🏼👍🏼🙏🙏🙏🙏
Not Just Parkinson's Most the Neurodegenerative disease can be controlled through Ayurveda Treatment I have been to VIAMS, an Ayurveda Hospital in Kerala, India Their approach is integrated Ayurveda with Physiotherapy, Psychology, Dietetics and Speech Therapy Find Them Dr. K.V. VIJAYAN INSTITUTE OF AYURVEDA MEDICAL SCIENCE PVT. LTD. Mezhathur P.O. Palakkad, Kerala, India - 679534 India Toll Free : 1800 123 00 2442 Direct : +91 9846362442 : + 91 466 2270142 Email : info@viams.in www.viams.in
You are AMAZING. I hope you continue making videos. There’s nobody like you. I’m going to donate to your Patreon right now. Quick question. With the neurons dying off, how would adding dopamine help? Without the transport vehicle, where does the dopamine go and how is it used? Is it flooding the neurons that are still “good”? Is that why carb/levo eventually stops working - bc all of the transport vehicles are gone?
I want to know how did you understand all of this.. And memorize it 🥺 you are amazing I understood the explanation but i couldn't focus more to memorize it
I didn't personally like how you changed the example from the first case (without dopamin) to the second case (with contribution from dopaminergic neurons).. makes me kinda feel like those examples aren't correct since they can't function coherently. As for everything else, very good video, so useful, thanks :)
Hello, Excellent teaching here! All my compliments. I would like to ask about ACh releasing striatal interneuron effects. The D1 sensitives neurons are sensitive to mostly M4r and D2 sensitive neurons possess M1 & M4 in my knowledge. I'll appreciate very much your explanation about this contradictory effects of ACh-Interneurons on D1 sensitive or D2 sensitive striatal neurons. Greetings
You said direct pathway stimulates agonist and indirect pathway inhibits antagonist. Dopamine by it's action stimulates direct pathway inturn stimulating and intensifying agonist and inhibits indirect pathway and inturn antagonist are stimulated. Isn't it? Then what is the use of activating both agonist and antagonist simultaneously
Nimja Nerd, I have a neurodegenerative condition Superficial Siderosis. It shares symptoms with PD and MS. It would great to see a video done by you discussing Superficial Siderosis. Thank you! Your videos are outstanding. 🎯
Perfect explanation. Thank you so much. Could you please make up a video on the pathopgysiology of restless leg syndrome and why dopaminergic drugs work for it? Thank you.
As always very nice and informative content from you!! Can you also do the clinical presentation about alzheimers and other neurodegenerative diseases?
Excellent! one small detail: it would be even better if you would give a little notion or formulation about striatum. Otherwise very good presentation.
Medicine is the most complex field of study. Insane stuff. To have the hormones and neurotransmitters isolated themselves would be a feat to me, to know their individual biological actions is just so cool. What are your thoughts on SSRIs?
pretty solid, although my textbook includes the caudate nucleus as the first step where excitatory neurons first arrive before it continues to the putamen.
You're an angel in disguise for all the medical students out here. Many thanks for your service 🥺❤
I was a cardiac nurse but left the profession for twelve years and I am taking a refresher course to regain my license! Unfortunately just reading textbook doesn't work, thank you so very much for your help in getting another nurse, me!, back to what I love..my patients and caring for them! I am blown away by your videos! Again can't say enough, ty ty THANK YOU! I am recommending you to my course director!
I literally want to cry from happiness because YOU HAVE EXPLAINED IT ABSOLUTELY BRILLIANTLY and I am so glad I understand it now! THANK YOU THANK YOU THANK YOU
lol
Nice to meet you.
Pasien Parkinson from Indonesia
❤
❤
WTAF I wasted 2 days trying to get my hear round this for my exam and you just did it in 30 minutes.
Genius. God bless you!
Ur existance is blessing for us God make u beautiful no need designer clothing to enhance your beauty
Beautiful 😍
5 years later and this video is saving PT students lives on the daily. Thank you!!!
Is this guy a doctor? I'm just really grateful for his THOROUGH explanations!
He is a med student i believe ...
His name is Zach Murphy. He is a PA. he was tutoring ppl on science and such and he decided to dev this Chanel to help ppl like you and me trying to understand w/o pulling our hairs out
Everyone should see all his videos and understand thoroughly before getting admitted as medical student. He is an awsome teacher and an awsome person.
Your explanations are the best thing one medical student can find on youtube..!! Thank you for making lifes of a medical student like me easy ...!
It took watching this twice for me to finally, properly understand the basal ganglia pathways. Amazing. Your lessons are seriously helping me.
Every time I watch ninja nerd it makes me sad that I haven't watched more ninja nerd sooner. Everything clicks! You are literally the best teacher ever!
Your's is the best on TH-cam..Can you make a video on basal ganglia connections?
This is basal ganglia only , Parkinson's affects the basal ganglia
Guys, these are bots and it's a scam. Do NOT fall for it.
bruh the level of detail you go into is insane, so helpful, you a major G
22:50: MIND BLOWN. Literally hours of studying in and this was the moment it all fit.
as much as Zach and the team blow my mind with how well they're able to explain these concepts, it's still amazing researchers were even able to work all this out in the first place
You just the best in all internet. What you do is something beautiful. You deserve the best
Just submitted my neurological disease research paper and you honestly saved my life.
Best medical tutor on earth🤜
Do you know about MS Dhoni ?
Do u know zack? he is greater than msd for me😋
Do u know zack? he is greater than msd for me😋
Yes
Poor captaincy by Rohit Sharma @@amanrathore923
Thank you ! It’s crazy how you can explain all of these in a simple manner.
This guy is amazing. I never had a professor like him. Total Nerd crush
That was intense !!! Like a good movie ! You take the time to develop each protagonist and each time a new one comes it adds suspense and interest. The end of this video... JUST EPIC ! the paradox being resolved and the synopsis for the part 2 ! Brilliant !
I am not a medical student but i love this guy a lot.
My father has PD and i’d like to find info about his disease.
Thank you a bunch ❤️
Your explanation was the best, and I've seen Khanacadamy and other big names where they used a chart-like explanation. Yours was exceptional. Thank you!
Shoutout to those extremely beautiful drawings on the board just complementing to what he is teaching!!!
Basal ganglia /nuclei starts from 5:25.
.
Thanks a ton doctor !!!
One of the best video ever. You are the best teacher I have ever seen
Just remember..stimulation of direct pathway cause stimulation of cortex..while stimulation of indirect causes inhibition of the cortex
*Motor Cortex or CorticoSpinal Tract
your level of knowledge and the obvious love of what u do is truly inspiring ..thank u from the deepest bottom of my heart
Best professor I have ever seen in my life, love youuu sir
Watching this, after my mom succumbed last month to complications from this disease, really hits hard. Softens the blow a bit, to understand the process more. Heartbreaking and hideous disease process💔
Sometimes I wonder what I should’ve done if your videos don’t exist I appreciate your hard-working
WHERE AND THE HELL WERE YOU, WHEN WE WERE IN MEDICAL SCHOOL. ONE OF THE PREMIUM TEACHERS OF SO MANY DIFFERENT TOPICS. LOVE HOW YOU GROUNDED THE MAJOR STRUCTURES EARLY IN VIDEO, BY FAR ONE OF THE BEST
this was really really amazing explanation! i watched many videos before this one and i also read this part from dipiro book and they weren’t enough for me to understand the whole thing!!
THANKS A LOT ❤️
honestly, you’re the best teacher i have ever known
Perfect summary! maybe rename this video to Basal Ganglion overview or something because it took me forever to come across this gold! Thanks for This vid!
Summary
Direct:
Cortex (glu) + SubNigra (D1)→ ↑striatum (↑Gaba) → ↓globus pallidus internus (↓Gaba) → ↑thalamus → ↑motor cortex
Note how the increase in gaba at the first step decreases gaba at the second step, effectively cancelling each other out.
Indirect pathways:
Cortex (glu) + SubNigra (D2)→ ↑striatum (↑Gaba) → ↓globus pallidus externus (↓Gaba) → ↑subthalamus (↑glu)→ ↑globus pallidus internus (↑Gaba) → ↓thalamus → ↓motor cortex
Am crying with joy 😭😭😭 no words for your amazing work
Very beautifully and clearly explained presentation! Thank you for making me understand better! Thank you so much from Malaysia 🇲🇾 4/8/2019
THERE ARE NO WORDS THAT CAN DESCRIBE HOW AMAZING YOU ARE! We need a video about Alzheimer Disease ASAP PLZ1
I think.....I got it....now I can start my journey......about Parkinson's disease...thank u sir.
This video was exceptional! Thank you very much! Can you please do a video for multiple sclerosis like the ones for PD? It would really help...thank you!!
Best medical teacher
the best teacher ever
youuuuuuuuuuuuu are my all time fav teacherrr
You are a total genius. I cannot thank you enough. What a fantastic overview of PD. Than you, thank you.
You're saving my neuroscience degree not even kidding 😂😂 thank you so much💜
Excellent explanation, thank you so much for making it so accessible.
Best explanation ever!! You’ve saved me of got a D in college 😂 hi from DR 🇩🇴
Bestest lecture For the students. One an only video from where I acquire the knowledge on parkinson's disease. Great job thank you sir
You are a very good teacher... I've a request...can you just speak a little slower it's difficult for me to get you some times ... other wise I have a great respect for you sir
I'm so thankful for this research!! How do you erase the past of all the people that rejected you and treated you like dirt out of sheer ignorance?
Not Just Parkinson's Most the Neurodegenerative disease can be controlled through Ayurveda Treatment
I have been to VIAMS, an Ayurveda Hospital in Kerala, India
Their approach is integrated Ayurveda with Physiotherapy, Psychology, Dietetics and Speech Therapy
Find Them
Dr. K.V. VIJAYAN INSTITUTE OF AYURVEDA
MEDICAL SCIENCE PVT. LTD.
Mezhathur P.O.
Palakkad, Kerala,
India - 679534
India Toll Free : 1800 123 00 2442
Direct : +91 9846362442
: + 91 466 2270142
Email : info@viams.in
www.viams.in
I'm very thankful for your videos, Dr Murphy.
How can someone even dislike these videos!!!
as always, great for my med studies...confused, when you want a strong contraction of biceps you increase the signal to its corresponding cortex area, but at the same time you increase the signal to the corresponding triceps area, which as a result contract as well, which works against the movement of the arm.
Dr Noah holistic healing herbal medicine is the best to treat Parkinson disease, i have been batheling this deadly disease for years now knowing full well my days are numbered. My Doctor prescribed some medication for me (Levodopa) which I was taking to help subdue the disease, at a point I was off my meds and the disease started to kick in.
I decided to do research for an alternative cure which leads me to a blog where a patient was testifying about Dr Noah herbs, i was overwhelmed and ought to give it a try. To my greatest surprise i am free from parkinson with no much talk get in touch with Dr Noah via:
Email: dr.noahmedicalcenter@gmail.com
Call +1 310 982-4670
Visit website: noahmedicalcentre.webs.com/
This is such an incredible explanation of this complex disease. Thank you so much
👍🏼👍🏼 I am a Pk patient . 🤔Too much info for my brain to process and retain 🤯🗣But your presentation is amazing 👏🏽👏🏽and also good source of reference that I will frequently go back to👏🏽. 👍🏼👍🏼👍🏼🙏🙏🙏🙏
Not Just Parkinson's Most the Neurodegenerative disease can be controlled through Ayurveda Treatment
I have been to VIAMS, an Ayurveda Hospital in Kerala, India
Their approach is integrated Ayurveda with Physiotherapy, Psychology, Dietetics and Speech Therapy
Find Them
Dr. K.V. VIJAYAN INSTITUTE OF AYURVEDA
MEDICAL SCIENCE PVT. LTD.
Mezhathur P.O.
Palakkad, Kerala,
India - 679534
India Toll Free : 1800 123 00 2442
Direct : +91 9846362442
: + 91 466 2270142
Email : info@viams.in
www.viams.in
Video just started and so adorable already.
Is he a Neurophysiologist ? Excellent lecture covering all basics.
Wow!!! Wow!!!! Thank You, Ninja Nerd!!! ❤️🙏🤗
I saw that in some videos you can use subtitles. Why in other like this is not possible? Meanwhile, Thank you very much for your efforts
Thank you so much, you break it down so easily. You are so Great !
Sir.. can u do a video on latest information about PARKINSON'S DISEASE. Please..
You are AMAZING. I hope you continue making videos. There’s nobody like you. I’m going to donate to your Patreon right now.
Quick question. With the neurons dying off, how would adding dopamine help? Without the transport vehicle, where does the dopamine go and how is it used? Is it flooding the neurons that are still “good”? Is that why carb/levo eventually stops working - bc all of the transport vehicles are gone?
Sir I literally love your all lectures 🥺
I have a request, please make a lecture on guillain barre syndrome
You are an amazing teacher! Your channel is one in a million 👍👏👏👏👌👌👌👌👌
I want to know how did you understand all of this.. And memorize it 🥺 you are amazing
I understood the explanation but i couldn't focus more to memorize it
I didn't personally like how you changed the example from the first case (without dopamin) to the second case (with contribution from dopaminergic neurons).. makes me kinda feel like those examples aren't correct since they can't function coherently. As for everything else, very good video, so useful, thanks :)
Thank you so much....You are such a great teacher
Your explanation made it all understandable. Thank you!!!
Would you any plan to give a lecture on Motor Neuron Disease and Multiple Sclerosis.Thanks in advance
Thank you sir for all these amazing videos you have been making for us. I'll request you to make a video on Alzheimer's disease. Thanks 😊
Perfect teacher
Amazing 🤯🔍✅ Thanks for SHARING
a very good approach . easy to comprehend
Love everything you do. I learn so much from you. Zac your my hero!
Seems like a gentleman on the way to a medical professorship
Hello, Excellent teaching here! All my compliments. I would like to ask about ACh releasing striatal interneuron effects. The D1 sensitives neurons are sensitive to mostly M4r and D2 sensitive neurons possess M1 & M4 in my knowledge. I'll appreciate very much your explanation about this contradictory effects of ACh-Interneurons on D1 sensitive or D2 sensitive striatal neurons. Greetings
You said direct pathway stimulates agonist and indirect pathway inhibits antagonist. Dopamine by it's action stimulates direct pathway inturn stimulating and intensifying agonist and inhibits indirect pathway and inturn antagonist are stimulated. Isn't it? Then what is the use of activating both agonist and antagonist simultaneously
Fascinating teaching skill
I suggest one on Alzheimer's disease
Nimja Nerd,
I have a neurodegenerative condition Superficial Siderosis. It shares symptoms with PD and MS. It would great to see a video done by you discussing Superficial Siderosis. Thank you!
Your videos are outstanding. 🎯
गुरु ब्रह्मा गुरु विष्णु गुरु देवो महेश्वरा।🕉️🙏
you are the best tacher
Perfect explanation. Thank you so much.
Could you please make up a video on the pathopgysiology of restless leg syndrome and why dopaminergic drugs work for it? Thank you.
As always very nice and informative content from you!! Can you also do the clinical presentation about alzheimers and other neurodegenerative diseases?
pleeeeaaaase we need videos about Epilepsy😓😓😓😓
Excellent! one small detail: it would be even better if you would give a little notion or formulation about striatum. Otherwise very good presentation.
Please Make Video on Alzheimer's disease pathophysiology, cause, cure symptoms and new research in this area
o man your presentation is very good thanks love from Pakistan
wow wow wow wow wow. best explanation ever.
I NEED ENGLISH SUBTITLE TT
I can't understand all of your words in one time .
edit : I love your clips and channel anyway.
You are the best ever ❤️👍
Medicine is the most complex field of study. Insane stuff. To have the hormones and neurotransmitters isolated themselves would be a feat to me, to know their individual biological actions is just so cool.
What are your thoughts on SSRIs?
please explain about inhibitor acetylcholinesterase
Your videos are my favourite. Love your shirt
pretty solid, although my textbook includes the caudate nucleus as the first step where excitatory neurons first arrive before it continues to the putamen.
also, what about the hyperdirect pathway?
bradikinesia, from greek, is slow movements, akinesia is difficulty to initiate movements
This is very informative. MayI suggest out scientist to develop a procedure or devicr to maintaine the
Thank you so much 🧠🧠🧠
Hello! Congratulations on your work, very clear and well explained! But I can't play the subtitles for this clip! Thanks:)
amazing as always .... keep making more ! Thanks so much