Neurology | Upper Motor Neuron vs Lower Motor Neuron Lesion | UMN vs LMN Lesion

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  • เผยแพร่เมื่อ 19 พ.ค. 2024
  • Official Ninja Nerd Website: ninjanerd.org
    Ninja Nerds!
    In this lecture Professor Zach Murphy will present on the pathophysiology and characteristics of an upper motor neuron lesion and a lower motor neuron lesion (UMN vs LMN lesion). We hope you enjoy this lecture and be sure to support us below!
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    #ninjanerd #UMNvsLMN #Neurology

ความคิดเห็น • 953

  • @imperfectmammal2566
    @imperfectmammal2566 3 ปีที่แล้ว +553

    Best teacher to ever exist in this planet!!!!!

    • @rjkmdb
      @rjkmdb 3 ปีที่แล้ว +2

      So true

    • @hillsongirl1
      @hillsongirl1 3 ปีที่แล้ว +5

      His kids will be blessed, hope he does pass on his DNA

    • @MsElina28
      @MsElina28 3 ปีที่แล้ว +2

      Amen!

    • @Foodies28Joy
      @Foodies28Joy 3 ปีที่แล้ว

      True❤️😍

    • @prashant23ify
      @prashant23ify 2 ปีที่แล้ว +2

      Sir I have a dbout please help me solve it .
      If UMN lesion is present, obviously no signals are passed to lower motor neurons, so there should be less release of acetylcholine ….. so basically umn=lmn … why there’s a difference???

  • @ismaelbarzani6064
    @ismaelbarzani6064 11 หลายเดือนก่อน +38

    You deserve to be named as the father of explaining and teaching

    • @NenehAgan
      @NenehAgan หลายเดือนก่อน

      where do we vote🥹

    • @selwynhenriques2614
      @selwynhenriques2614 2 วันที่ผ่านมา

      Very useful to understand difference between upper and lower motor neuron lesions ,really appreciate the ton of research you put in to give us such a detailed and simple to understand explanation .

  • @ArundhotiRay
    @ArundhotiRay 2 หลายเดือนก่อน +9

    Throughout the medical life I felt pain whenever I saw the word UMN & LMN because I didn’t understand these complexity. Thank God, I can die in peace now bcz I understand upper & lower motor neuron lesion.
    Thank you ninja nerd, you are the best teacher of this planet.

  • @sabaripaulmajumder5196
    @sabaripaulmajumder5196 3 ปีที่แล้ว +167

    Love from INDIA

    • @Destinyschild777
      @Destinyschild777 8 หลายเดือนก่อน +1

      Same bhai, best teacher in the world

    • @piyushgadegone5107
      @piyushgadegone5107 2 วันที่ผ่านมา

      Ye Ranveer Allahabadia jaisa dikhta hai kya dosto?

  • @djay909
    @djay909 3 ปีที่แล้ว +258

    How this man keeps going all from his memory without a single hiccup is beyond me 🤯

    • @evilreborn4088
      @evilreborn4088 3 ปีที่แล้ว +14

      Practice. He prepares every lecture. Then practice and then shows us the final product.
      He Is seriously good. All concepts getting cleared

    • @drdebocherry
      @drdebocherry 3 ปีที่แล้ว +3

      He is the Master of the Universe, as in Queen Song!

    • @ghadderd.3444
      @ghadderd.3444 2 ปีที่แล้ว +12

      صلي على محمد لا تحسدينه

    • @BrianHurd
      @BrianHurd 2 ปีที่แล้ว +1

      Pretty sure some of the minutia is on a monitor off screen (but I could be wrong!), but 90% he knows. He is a badass.

    • @seemo5681
      @seemo5681 2 ปีที่แล้ว

      @@ghadderd.3444 منجد فجعتني ليتها تقول ماشاءالله

  • @mimansa_sah
    @mimansa_sah ปีที่แล้ว +9

    Seriously - 4 hours of uni lectures - distilled into pure gold.

  • @riturajmajumder2055
    @riturajmajumder2055 2 ปีที่แล้ว +5

    Zach , you are like one of the best med teacher in the planet currently.

  • @Desert-123
    @Desert-123 วันที่ผ่านมา

    This is the best video on the internet . Thanks for being short and so comprehensive !❤

  • @SF-es3ff
    @SF-es3ff 2 ปีที่แล้ว +4

    So much respect to you, attempting to get into PA school and discovering how hard that can be! Your videos provide an in-depth understanding that I probably couldn’t get elsewhere this easily! May God bless you for all your efforts!

  • @josetrujillo738
    @josetrujillo738 3 ปีที่แล้ว +21

    The way you teach is honestly amazing! Thank You Zach! Shout out Kristen! Shout out Rob! Thank You Ninja Nerd Lectures!

  • @jeffreyrayner5235
    @jeffreyrayner5235 3 ปีที่แล้ว +3

    Thank you Zach. I have been recently diagnosed with MND and a fell into a dark space. Your lecture has clarified my case such that I can understand what I may or may not have. This allows me to understand and deal with what could have been a total despair.

  • @amirulazam5034
    @amirulazam5034 2 ปีที่แล้ว +4

    3 years of doubt and confusion cleared in 1 hour lecture... THANK YOU VERY MUCH..

  • @tanziasharmin7364
    @tanziasharmin7364 2 ปีที่แล้ว +5

    I was waiting for so many years for this video...passed MBBS some years back.. I used to memorize UMN &LMN Lesions.. But this time i wl never forget....Great teacher..! Wonderful way of teaching...

  • @evelynperez2486
    @evelynperez2486 3 ปีที่แล้ว +6

    I just wanted to say that I freakin love your videos! You truly helped me pass advanced anatomy in my grad program! You have a gift of teaching things very clearly something some professors do not know how to do!!!!

  • @manishaprja
    @manishaprja 3 ปีที่แล้ว +3

    Thank you so much for this. Best teacher! No one taught this in so simplified form in medical school. It helped me a lot.

  • @aakashkumarsah8616
    @aakashkumarsah8616 3 ปีที่แล้ว +24

    Neurology seemed so tough to me.You made it so easy zach🤗🤗. Thank you ninja nerd team❤🇳🇵

  • @flypnay704
    @flypnay704 3 ปีที่แล้ว +60

    Zach & Ninja Nerds, you constantly blow my mind...in that good neuro way! This subject was so terribly taught at my medical school, thank you for making this clear!

  • @neethu4661
    @neethu4661 ปีที่แล้ว +24

    Being a medical student your videos are such a blessing to me... Thank you sir.. Finally understood it❤

  • @kyongvincent4385
    @kyongvincent4385 3 ปีที่แล้ว +3

    Love his lectures. How he can remember that much info. Genius

  • @christybiji1433
    @christybiji1433 3 ปีที่แล้ว +2

    You always manage to explain something so complex so well! Thank you!

  • @thehunchbackgirl
    @thehunchbackgirl 3 ปีที่แล้ว +66

    I would travel across the world just to thank you in person, Zach!

  • @spanishlatteMD
    @spanishlatteMD 3 ปีที่แล้ว +175

    so happy for you guys for what you have accomplished over the years! been here since 1st yr med school and I still am now that i am a graduating medical student! keep rocking you guys!

    • @obedbagona7402
      @obedbagona7402 2 ปีที่แล้ว +1

      Regards to MSU Med! - From ADZU School of Medicine

    • @danielpa8644
      @danielpa8644 2 ปีที่แล้ว +1

      In the MASS part of lecture - LMN lesions cause less protein synthesis (more protein degredation) then at 23:30 the muscle responds to a decrease in Acetylcholine by synthesizing more nicotinic receptors. How are new receptors being created when protein degredation is going on with a LMN lesion?

    • @honeybadger1621
      @honeybadger1621 ปีที่แล้ว

      hi,I'm type 1 diabetic 46 years old 15 years have neuropathy. I broken my tibia bone 4 screws and rod in my leg now. my question diabetic people's fracture healing? also neuropathy can made problem for healing process?

    • @sudeeptalapatra3982
      @sudeeptalapatra3982 ปีที่แล้ว +4

      @@danielpa8644 great qs Daniel.!..even when protein synthesis is less due to less Ach cell will try to make new and more nicotinic receptor so as to increase muscle pr synth with whatever protein the cell from the very beginning of UMN lesion and even in late phase it will destroy it's organelles
      To make N.receptors because it is the only means to maintain homeostasis for the muscle cell.

  • @sheliapdd758
    @sheliapdd758 3 ปีที่แล้ว +1

    Really help me to understand neurology class clearly. Thank you Zach. You did it great!

  • @judithumeadi2704
    @judithumeadi2704 2 ปีที่แล้ว +1

    Great revision session. Excellent teacher, delivered at just the right pace. Easy to understand and follow. Thank you!

  • @TheChartreusePenguin
    @TheChartreusePenguin 7 หลายเดือนก่อน +3

    I don't know how I'd get through medical school without you Zach! Thank you so much for teaching and sharing your knowledge - I literally don't know how to thank you enough

  • @britneyidapaulus750
    @britneyidapaulus750 2 ปีที่แล้ว +24

    This was aweeeesome😭
    I am basically hours away from facing my end of term internal Med exams and this was so useful 💡, the light to the end of my tunnel 💗

  • @fatemahh9459
    @fatemahh9459 3 ปีที่แล้ว +4

    Oh my God I have a neurology exam in the morning, you couldn't possibly have had better timing! I might cry with sheer relief and gratitude 🤧 Your videos are the only reason I'm surviving and feeling smart while doing it 😂❤️ Thank you soooooo much! I cannot possibly ever express my gratitude. You are a real inspiration!

  • @neelamjha7955
    @neelamjha7955 3 ปีที่แล้ว +45

    Ahhh!!!!! The most awaited video is here....🤩 Thank you Zach....I respect You and your work a lot...I really do...🤩🍰

  • @grdainylung5216
    @grdainylung5216 ปีที่แล้ว +3

    Please share this video to freshers in medical school,it's fucking awesome,I have wasted years studying books trying to understand this but you clearly described in simple way.Millions thanks to you.

  • @jillybasu8300
    @jillybasu8300 ปีที่แล้ว +34

    You guys are awesome, insanely good, the best teachers! Thanks for a great lecture Zach, it has really helped me understand about assessing for UMN v LMN lesions 🧠🤩🤙🏼

    • @elizabethwetzstein-cm1jp
      @elizabethwetzstein-cm1jp 8 หลายเดือนก่อน

      You have no idea how helpful those content is. I appreciate you.

  • @hsmith1180
    @hsmith1180 3 ปีที่แล้ว +1

    you get a lot of love in these comments and it's well deserved. I rely on these vids so much to supplement my "scholarly readings" because you break it down into much more comprehensible language. I'm not exactly sure how you do it but you make it so much easier to grasp. I watch bits over and over to make sure I have the idea correct. You are a legend

  • @amelonlord654
    @amelonlord654 3 ปีที่แล้ว +6

    Liked it and enjoyed it, definitely. I am so thankful, I was always very interested in neurology but found it quite complicated. You make all the complicated concepts seem understandable. I coudn't ask for anything more. And you even tell everything with such a spark that makes me want to binge watch your neurology playlist! Who would've thought..

  • @lifeingreatmoment5654
    @lifeingreatmoment5654 3 ปีที่แล้ว +8

    The best teacher I am eagerly waiting for him twice in every week

  • @guarkenchiman4427
    @guarkenchiman4427 2 ปีที่แล้ว +3

    His spirit challenges every mind to thirst more for knowledge. Thank you for your energy and time

  • @musicbeachdance
    @musicbeachdance 3 ปีที่แล้ว

    Saving my entire existence in Neuro thank you for explaining the findings for fasciculations!! So easy to follow!

  • @melissamonreal9486
    @melissamonreal9486 2 ปีที่แล้ว +2

    BLESS YOU!! You explained UMN vs. LMN in the first 5 min of this video better than my grad school professor did in a full semester. Thank you!!

  • @sudeeptalapatra3982
    @sudeeptalapatra3982 ปีที่แล้ว +3

    understanding Mechanism behind all these hyper reflexia and hyper Tonia makes it easy to memorise.... also gives an enjoyment 9f understanding the actual concepts behind...Kudos to your team sir for gifting such an amazing lecture.❤️

  • @scottwilson7633
    @scottwilson7633 ปีที่แล้ว +13

    Thank you for what you guys do. I've been using your videos all through undergrad and now in medical school, and I can honestly say that you are one of the main reasons I (and likely many others) have been able to make it this far. Ninja nerd will have a big donation coming their way after residency!

  • @cleopaschisanga5355
    @cleopaschisanga5355 ปีที่แล้ว +2

    You deserve tones of awards... This makes so much sense when examining CVA patients thanks so much ninja nerd🙏❤️

  • @H-ton-R-tonSN7893
    @H-ton-R-tonSN7893 2 หลายเดือนก่อน

    You're absolutely an amazing instructor, who feeds the whole world with knowledge through social media..

  • @VERA-jo3ev
    @VERA-jo3ev ปีที่แล้ว +14

    THIS IS LIFESAVING, i have a neuro class in 2 hours and this just was PERFECT!

  • @sandrak4032
    @sandrak4032 3 ปีที่แล้ว +3

    Amazing! I understood so many things in depth that I had been taught couple years ago

  • @andydonham8612
    @andydonham8612 ปีที่แล้ว +1

    Should be mandatory viewing for new PLS and ALS patients. Cleared so much up about the affliction. Thanks so much.

  • @jyotisamanta4997
    @jyotisamanta4997 3 ปีที่แล้ว +3

    Kudos and all the best wishes. This solved my never solving confusions ❤️

  • @marianapereira5370
    @marianapereira5370 3 ปีที่แล้ว +3

    Amazing lecture as always! When are you guys releasing the video about the physical exam? Btw love your videos, been watching them since my first year in medschool and I'm in my fifth now, and it's a lot thanks tou you! Keep up the great work!!

  • @mosab_emad
    @mosab_emad 2 ปีที่แล้ว +2

    I swear this is the best lecture I have see in TH-cam ,, Sincere love and respect Doctor ,, YOU ARE AMAZING!!

  • @rwuthenow
    @rwuthenow 2 ปีที่แล้ว

    That was amazing. Just basically taught about 400 pages of exam prep. Thanks for doing this. You have really exemplary teaching skills. I wish I could half as good a job.

  • @alih6953
    @alih6953 3 ปีที่แล้ว +8

    Zach you are helping millions of people. I am praying for you and your family so that God grants you with health and wealth. Thanks

  • @Iminoamino
    @Iminoamino 3 ปีที่แล้ว +14

    Being a medical student the respect and love I have for this person is inexplicable! Thank you

  • @hannahunt1175
    @hannahunt1175 3 ปีที่แล้ว +1

    Your enthusiasm is infectious

  • @mileyuli
    @mileyuli 3 ปีที่แล้ว

    I am so beyond thankful for this video! I couldn't understand the differences between them and was struggling and this was so so clear!
    Thank you so much you guys are life savers!

  • @arijoybhattacharjee6039
    @arijoybhattacharjee6039 3 ปีที่แล้ว +5

    I love you Teacher ❤️... From India 🇮🇳

  • @mrindian5908
    @mrindian5908 2 ปีที่แล้ว +3

    Thank you for the most woderful lecture with brilliant simplification of a complicated topic. I have one doubt - the inhibitory tracts from Medullary reticulo spinal nuclei are descending ipsilateral where as excitatory cortico spinal tracts are coming from opposite side of brain, so how these inhibotory tracts are damaged to produce hyperreflexia in UML when the UML lesion is actually on the opposite side of the brain. Pl clarify, thank you.

  • @DOT368ER
    @DOT368ER 2 ปีที่แล้ว

    Best to explain MND! My dad passed away from ALS a few years back started with the bulbar. I’m having symptoms of LMN with fascinations. This definitely give knowledge to determine what one has!

  • @granitklippa
    @granitklippa 2 ปีที่แล้ว

    Best teacher ever! My wife has recently been diagnosed with Progressive Bulbar Palsy and this video really helps me understand the symptoms. I am a Nurse anesthetist by training, but never really paid attention to this topic in the past. Thank you for posting, keep it coming

  • @ifrahakbar2283
    @ifrahakbar2283 2 ปีที่แล้ว +3

    One word for you: KING!

  • @obaidkhan2278
    @obaidkhan2278 3 ปีที่แล้ว +3

    Pure class of love 😍😍❤️❤️❤️❤️

  • @adeyemialexandra209
    @adeyemialexandra209 ปีที่แล้ว

    Sir, you are blessed with intelligence and the gift of teaching. Thank you for breaking down these hard topics

  • @EmmArwen
    @EmmArwen ปีที่แล้ว

    oh my god! i can not stop watching your neurology classes. i am a resident 5 th year in the neurology department. It is fascinating me after seeing you explain this staff!

  • @malihahoque5460
    @malihahoque5460 3 ปีที่แล้ว +19

    The way you connect physiology with medicine ; damn I'm in love !

  • @prasannabharathi2019
    @prasannabharathi2019 3 ปีที่แล้ว +5

    You make the topic more interesting by saying the word "beautiful " again and again 😍😌😍

  • @setarehabdoli3115
    @setarehabdoli3115 ปีที่แล้ว +2

    You are literally amazing,for years as a postgraduate specialist I was struggling for this topic,,,,,if there is a magician,its you❤

  • @qamaruddinkhan3847
    @qamaruddinkhan3847 2 ปีที่แล้ว +2

    Best teacher for understanding concepts 💞 kindly at the end of every lecture, cover the whole board so that we can take screen shot as well for memory

  • @User-to7nb
    @User-to7nb 3 ปีที่แล้ว +12

    Just here to leave a like and a comment for the algorithm

  • @akatodemyrus6077
    @akatodemyrus6077 3 ปีที่แล้ว +10

    I wish I could draw like him...

  • @neliakalenga2462
    @neliakalenga2462 2 ปีที่แล้ว

    Literally the best teacher anyone could ask for! My Med school life saver!

  • @tabitha2540
    @tabitha2540 11 หลายเดือนก่อน

    Amazing teacher! Your enthousiasm is contagious to understand this. You are brilliant as a teacher. Thank you soo much.

  • @balavantbhaipatel1969
    @balavantbhaipatel1969 3 ปีที่แล้ว +8

    My teacher is back.....whoooo

  • @SameerShaikhAdventures
    @SameerShaikhAdventures 3 ปีที่แล้ว +6

    FIRST ONE TO COMMENT. HUGE FAN OF YOU SIR. LOVE FROM PAKISTAN❤ do reply to me 🤒😂
    Stay Blessed❤

  • @zahraaammar2708
    @zahraaammar2708 3 ปีที่แล้ว +1

    the best teacher and the best channel ever , you literally are saving lives !

  • @mowsumisara1411
    @mowsumisara1411 3 ปีที่แล้ว

    Everytime i finished any lecture by you i feel like uff i love your teaching techniques...also i think its your teachings that makes me love mediacal science...thank you a very very much...😊😊😊

  • @daniaizzah4335
    @daniaizzah4335 ปีที่แล้ว +2

    last year med student here and your videos are god-sent!! thanks Prof! Many loves from malaysiaaa

  • @kelechi2352
    @kelechi2352 3 ปีที่แล้ว +1

    what a time to be alive.. I am blessed to have found this channel

  • @haleeyzkhair4121
    @haleeyzkhair4121 3 ปีที่แล้ว +2

    I have waited all day for this. Thank you Zach you are the best of all.!!!!

  • @easymedicine3677
    @easymedicine3677 3 ปีที่แล้ว

    i cannot express my gratitude , you really made physiology so simple for me thank you so much

  • @vinayakkapatral4246
    @vinayakkapatral4246 3 ปีที่แล้ว

    My Zach doze for the day!
    I was reluctant to see neurology classes but .... now I am hooked!
    Zachcellent!

  • @lollolez7147
    @lollolez7147 2 หลายเดือนก่อน

    Can't express how thankful I am, Appreciate the time you spend to teach us in such an efficient easy, and fun way.

  • @365bmmusic
    @365bmmusic ปีที่แล้ว

    You are really good at what you do. I have been struggling to understand this stuff for years so you have really filled the gaps in my knowledge, so thank you Ninja Nerd, keep creating and explaining, looking forward to watching more of your videos

  • @tamannaprety3563
    @tamannaprety3563 2 ปีที่แล้ว

    This video is so much helpful to clear concept about UMN & LMN lesions...
    Absolutely brilliant presentation...

  • @ishitachidrala6737
    @ishitachidrala6737 2 ปีที่แล้ว

    The way you...explain ,even the difficult topic seems to be easy..thank you👍

  • @heatherjean5674
    @heatherjean5674 3 ปีที่แล้ว

    You are so talented at making difficult concepts more understandable. Your videos are an absolutely Godsend!!!

  • @humanbeing3177
    @humanbeing3177 2 หลายเดือนก่อน

    What an extraordinary lecture you have prepared and made it available for free for real. I am so thankful to you.

  • @eman-ne2ng
    @eman-ne2ng ปีที่แล้ว

    42:33 that smile on your face made me smile, Zach. You love to teach and it shows, always! Appreciate everything you do :)

  • @Honey-nv9dp
    @Honey-nv9dp 2 ปีที่แล้ว

    I'm thankful to Ninja nerd for the most simplified yet difficult concepts. Thank you for making med school make sense 💖

  • @iApatheia
    @iApatheia 3 ปีที่แล้ว

    Very timely for my Neuroscience class! Thank you @Ninja Nerd Lectures!

  • @garycovington7925
    @garycovington7925 ปีที่แล้ว +1

    As someone diagnosed with PLS (Primary Lateral Sclerosis, UMN) over 29 years ago and heavily involved with PLS email groups then Facebook PLS groups (1400+ members) for around 25 years that's the best explanation I've yet seen! Thank you! 👍
    The only thing I have issues with is the explanation of fasciculations as being LMN. Almost every one of the 1400+ PLSers in our Facebook group, including myself, have fasciculations yet I'm sure after 31 years from first symptoms I have PLS with UMN symptoms only. The connection between fasciculations and fibrillations measurable on EMG seems tenuous because most of us with serious fasciculations have had EMGs which show no LMN involvement.

  • @goldenleaves9465
    @goldenleaves9465 2 ปีที่แล้ว

    Smart, genuine, passionate. You are the best!

  • @kindkindo4210
    @kindkindo4210 3 ปีที่แล้ว

    You help me so much. I love your way to make the lecture clear early.. thank you so much

  • @simplyy.lylaa7
    @simplyy.lylaa7 2 ปีที่แล้ว +2

    Wow, you should honestly be a teacher! This is amazing!!!

  • @carriehope8152
    @carriehope8152 2 ปีที่แล้ว

    I have been struggling learning this, you made it so clear. Thank you!!

  • @mdbadar8286
    @mdbadar8286 ปีที่แล้ว

    i really enjoyed your teaching on febrile seizures.wonderful.Great teacher ,you are.

  • @gladysarpen7549
    @gladysarpen7549 ปีที่แล้ว

    Thank you Prof Zach, this made so much sense, finally understood it! Bless you

  • @ngulabs8300
    @ngulabs8300 2 ปีที่แล้ว

    Wow, very impressed with the way everything was explained. Great job!!!

  • @siddhantpradhan1419
    @siddhantpradhan1419 3 ปีที่แล้ว

    This video is just gold
    I don't think anything is more precious than this
    Thanks Sir for all the effort , this lecture is so very helpful.
    I searched a month looking for this concept in all the places I could .
    Thank u sir
    Lots of ♥️ and respect .

  • @sisaytefera8278
    @sisaytefera8278 2 ปีที่แล้ว

    You are best teacher! I am enjoying neurology because of you! Stay blessed!

  • @joymutheu7737
    @joymutheu7737 ปีที่แล้ว +1

    You really explain in depth ❤️..most times we don't stop to ask why some things in medicine happen the way they do but you explain it all❤️😍

  • @saveetapurswani5316
    @saveetapurswani5316 3 ปีที่แล้ว +1

    OMGGG I was waiting for this lecture and its here. you explain in the best possible way, cant thankyou enough sir, god bless youu

  • @julieforsyth4349
    @julieforsyth4349 2 ปีที่แล้ว

    I finally understand WHY we have the signs and symptoms of UMNL vs. LMNL! Thank you!

  • @narjis7935
    @narjis7935 3 ปีที่แล้ว

    I love how passionate u are when u teach

  • @Mercyforthewicked
    @Mercyforthewicked ปีที่แล้ว

    amazing and easy to understand video! my professors mentioned the results of the lesions but not why so i left with questions, but this makes it so easy to comprehend