Dr. Rhona I hope this will get your attention: IGF-1 is associated to development and metastasis of cancer, if Sauna use is promotes IGF-1 does it also mean the use of Sauna is also Cancer promoting? and what is the difference of IGF1 from Food and IGF1 caused by Sauna use and Exercise in relation to Cancer?
Intelligent, gifted, and a sweetheart without a big ego. Making difficult subjects more accessible and easy to follow. Years and years of research made understandable for everyone.
I don't agree with what you said at the end of the video. Actually, it's all about pulsivity.. you can pulse IGF-1 from time to time to promote growth in your system, then follow this with a long period of caloric restriction to clear your system, then reperform the cycle, I think that's the secret to a healthy long life, just pulses of growth followed by a period of autophagy..
Exactly my thinking too, great insight. Do you have any other sources you like to watch / listen too I’ve just come across Rhonda & keen to find other great sources
This is a real dilemma, especially past 40. I still think it's worth 3 months in an anabolic state at any age to get the muscle mass up and do everything you can to maintain it. A good interview would be with Dr Sullivan who wrote The Barbell Prescription.
Exercise physiologist here, there is actually no inconclusive date that shows High intensity exercise increases life span (longevity). Actually quite the opposite, slow steady state movement (walking) is the greatest factor for longevity across broad spectrum studies of varied genomes
Great ! I spend 10 -12 hrs in the Gym weekly . . . (resistance training and cardio) I consume Green Tea and Turmeric daily, and dark chocolate once a week. My MD says that my physiological age is in the early forties . . . However, I will be 70 in a few months ! I'm glad to see that I am on the right track . . . Thanks so much for sharing !
Cholesterol, PSA, BP? Mine are 163, 1.73, and 112/72.............I am 70 years old. I take no medication for cholesterol or BP or anything else for that matter.
You are absolutely incredible! I have been looking for a clear and concise comparison relationship between IGF-1 and GH. You knocked it out of the park.
I wouldn't say the relationship between longevity, performance, growth factors is super straightforward. There are lots of animal models that don't follow the expected path (I think there are a couple reviews that cover growth hormone/igf-1 manipulations), and there are plenty of other chemicals that affect performance and longevity, making context important.
As far as I've read a hot bath does not elevate the core body temperature as robustly as a 30-60 min. sauna session. It is the intense heat stress that induces a massive rise in GH. My next video is going to be on this topic since there has been significant interest on the effects of sauna. If you've subscribed to my channel, then you should be notified when this video goes live.
In other videos you said that caloric restriction is good for longevity but in this video you’re advising us to caloric restriction. It’s a bit confusing. What’s the definition of caloric restriction? Is intermittently fasting considered caloric restriction?
@@bfharb What is confusing in caloric restriction helps longevity vs her advising us to restrict the caloric intake? You can find explanation if you google it. It will probably be the first result. IMO the term can be a bit confusing because it is relative to one's current diet and lifestyle. If one already has optimal caloric intake for current lifestyle (Iron bender probably needs more calories than a guy who spends all day in a chair and occasionally jogs.). Intermittent fasting can definitely help you to restrict/reduce caloric intake.
I love how fast you speak. It's so relaxing. When people speak too slowly for me I get agitated. I often use the speed up function of youtube for that reason. Please keep up the tempo, I'm loving it.
I have been trying to manage my health since my 20 and as I am now 70 years old I feel very blessed. Thank you for your information, it was enlightening because I have been weight training to maintain my muscle mass and trying to increase my IGF-1 to reduce fat storage.
Congrats, you're on the right track. If you haven't already, you might want to check out the Ketogenic diet, which seems to dovetail very nicely with HGH/IGF-1 supplementation.
DYOR on Keto. I strongly disagree with KETO. Oil is a absolut killer. A Keto diet is NOT sustainable it’s only for short term goals such as weight loss which will have a longterm effect. That’s ok. But not Keto longterm
Ill tell you something right now considering i do take gh. I know it has reversed aging related issues that i have had as i have aged. In fact i believe some of my hair color has even returned to some extent. Increased healing time from work outs and many other benefits. I am not a mouse worm or fly. I would rather live a higher quality of life regardless rather than live longer and a horrible quality of life. You should really think of this as you age and lay in your death bed.
Awesome job Rhonda! It was simple enough, and short enough for my mind to be able to follow and absorb the information. And it gave me good options. Well done.
Hardly. No one increases their GH levels to 100 fold. They don't even increase them 10 fold with gh supplementation. So her gym only advice for increasing GH is pure stupidity particularly for aging adults who cant recover fast enough to benefit from a "gym only protocol" for gh supplementation. If you're about 45, you MUST supplement gh if you want longevity and quality of life, recovery etc. while exercising at the gym. Peptide CJC1295 w/dac is the best way to supplement gh. Dont waste your time and health on HGH. There are too many side effects and complications.
@@stephencarlsbad you can actually increase GH levels 2-10x your natural amount with CJC1295 (peptide) and even further with GHRP secralogues (wrong spelling) and even further with HGH. Plus adding time in the sauna and plenty of sleep and exercise, one can theoretically boost natural GH levels well over 10x the natural amount
Neurodivergent. There’s a fine line between yelling and speaking up. The yelling activated my stress response so I only understood about 1/4 of what she was saying. I wish I were kidding, but I’m not. (Really low GH here, hence the hyper-reactive stress response)
Since your comment is pretty high I'll throw it in for others to see. This is particularly true for animals, they not only live longer (usually 30%) but are also in WAY better health. The difference is, for humans it seems not to neccessary increase longevity, BUT it reduces the amount of agerelated diseases immensly. So we might actually be old age and strong and healthy. A 5 day waterfast once every 3 months or minimum 2x a year seem to keep the benefits going.
@@Bankai90 Largest ever human experiment with caloric restriction was great depression, result: bump in life expectancy of 6.2 years ur.umich.edu/0910/Oct05_09/19.php
@Zegarac Robert that study is interesting I don't know why some answers never pop up for me hah The thing is, most people would have a hard time to restrict food for several decades without putting too much stress from various sources for in this age. And who wants to live life that restricted let's be honest here haha. Dr Ronda has another vid here about autophagy and they talk about the same benefits mimicking a calorie restricted life can be gotten through two waterfasts a year. @Yana Nova Vlogs it seems to be that what makes us healthy is a mix of short (even intense) stress and a recovery period. That's why prolonged fasting is so great, we give the body the time to heal. Autophagy usually peaks already at 3 days after starting a fast (if we have been in ketosis from the start), If we eat carbs a 6day waterfast would be more appropiate, that's why the 5 day rule seems quite on point. Autophagy also rids ourselves of senecent cells which just stay in our body and inflame us. Fixes gutbiome so long refeed is good etc. Aswell every of those natural stressors seems to activate all pathways associated with longevity and health. Cold showers, Sauna, Breath work(hypoxia), exercise. Better to fast 2x a year, get in ketosis prior the fast. Maybe do 3 keto days earlier. Then do sport and some yoga flow exercises, some days some real stress like ice baths here and there, eat yo greens and enjoy life^^
When fasting 20/4, there is no hunger and so no suffering and you know when to poop and no need think about getting foods; Food taste way better this way (GH up due to dopamine up) and I even did a nonsufferingly feeling 30 km. kajak tour in end of fasting once without feeling deprived, but I was really quiet in my mind after that; Nice!
But what if it is possible to live say 150 and still be active and in good shape both mentally and physically whilst being 120 as today's 60s are? With that logic you are about to reduce half life and also half cognitive excellence. That is huge difference in my opinion. I mean if the typical old person lives to 75 today imagine how much evolving world you would see if u was to double that and live to 150
Dr. Rhonda Patrick is like that cool teacher everyone wishes to have. I started drinking green tea daily and eating the leaves for 2 weeks now. Really feel better now! I can even focus more when studying!
A video on IGF-1 that does not mentioned anything related to its effects on cancer in humans, neither the foods that causes it production to increase... could you please comment on that?
Hi Dr. Patrick, i´m glad you explained this in Detail. I already heard you elaborate on this in Tim Ferriss Podcast, though it was hard for me to follow. I wasn´t entirely sure, if I got everything right, because of English beeing my second language. Here it was very clear and i´m very happy, i got it right in the first place. Thanks a lot! Thomas Hansen PS: Your voice is fine! And even if it weren´t, your information is too important to miss just because an subjectivly felt inconvenience. Please keep it coming.
There is a correlation between IGF1 and cancer, from what I've read. "Performance" is an artifact of the mating cycle, which, once it is gone, does not wear well on an old body.
Thank you, I’m curious as to why this correlation wasn’t addressed, it’s the only reason I have my doctor monitor my IGF-1 levels. It’s not like this is an arcane aspect that can’t be discussed or at least mentioned in a short video.
There is a video with Rhonda on meat in which she explains that higher meat consumption (which drives higher IGF-1) is only correlated with increased mortality in people with other risk factors, like sedentary lifestyle or excessive alcohol consumption. Basically, exercise helps IGF-1 get into the muscles and the brain, where you want it, as opposed to it staying in the blood and causing tumor growth.
You are an absolute badass! Thanks for everything you put up on this channel!! So how do you feel about supplemental igf-1 for short term boosts in muscle mass increase and adipose decrease?
I'm a body builder and i believe i have so insight here , given i experiment often with igf , fasting , calorie restriction and bulking over the course of years all while collecting my own personal blood work along the way . This is more than guessing in my opinion .im 35 with a ifg of 100 naturally and it has been around that naturally for me since my early 20's. When i fast which is every day for about 16-18 hrs igf 1 has never raised but maybe 10 points if im lucky. When i cut which is on average 5-6 months every year there is maybe a rise in igf 1 by 5 point if im lucky . when i am in a calorie surplus to gain lean mass along with training . ifg1 stays the same which is for about 8 months our of the year. my diet is always well balanced full of fiber . There is nothing in my experince that is going to alter you genetics for a higher igf1 naturally vs taking somthing like a peptide . I take MK 677 and it take me from 100 to 200-230 for IGF. Just like anything else , it should not be abused . At leves of IGF 1 100 or below i feel sluggish , fat gain is easier , Fat storage is around my main organs , brain function is slower , sleep is worse , skin is worse , hair is thinner , the daily need for afternoon coffee , bones and muscles are more ache , just about everyint in life is worse . Just taking the levels to 200 changes all of this for the better . You decide what you want i guess , My thought is just be responsible with it . Get blood work done , optimize your nutrition and exercise.
Thank you. Similar story to yours. 41 years old been taking hormones since 23. Testosterone and GH. I eat unprocessed natural oil free organic foods. Rarely animal products. I agree with you. I’ll keep it short. We can share experiences to help us and learn from each other. I take synthetic GH Somatropin but I have also taken all GHRP GHRH IPAMORELIN CJC 1295 with or without DAC… etc Testosteron Never abused just 750 mg Max in my 20s The past 15 years on TRT 150-200mg week on different injection intervals. With HCG HMG DHEA AND PREG. My heart LV ist 12mm and perfect health. I do HIIT resistance training and Hogg and different interval speeds Ok to much info possibly but just fyi
"All of these things will make you feel like you are living longer, which in this case is a bad thing because you actually live longer." Living longer is good even if I lived in these conditions, which would give me more time to find the way to get everything at the same time.
So, fasting, for example intermittent fasting or warrior diet, suppose to extend your lifespan and increase lean body mass due to higher release of growth hormone, but you are saying that increased growth hormone decreases lifespan and muscle mass. I am confused. Could someone explain, please?
Fasting repairs cells by autophagy. It increases lean body mass by the release of growth hormone. Severe caloric restriction decreases muscle mass and increases lifespan in part by limiting growth hormone production and metabolism. Do not confuse fasting with chronic caloric restriction.
She just explained that more growth hormone your body produces = less expression of stress resistant genes that protect your cells from damage over time. Less growth hormone = more expression of stress resistant genes that protect your cells from damage over time. However eating those polyphenols and a healthy diet can enable those genes that protect your body from stress even while you produce high levels of growth hormones, therefore countering the negative effects of growth hormone (negative effect being more GH = less expression of stress resistant genes that protect your body over your lifespan and lead to shorter life).
intermittent fasting increases the expression of the stress resistant genes by quite a bit, possibly offsetting the increase in igf-1. What I've seen is that it tends to do more than that and offer a net benefit.
Any insignificant and temporary increases in GH from fasting has absolutely no effect on hypertrophy, so that's partly why you're confused. Practical significance is the important lesson here...
@@sinestatus Yeah, what about the ketogenic diet? As with calorie restriction and fasting, the ketogenic diet of course causes ketosis. And ketosis causes autophagy. So all of these methods will improve both health and lifespan, except in studies when autophagy is blocked. The key mediator appears to be ketosis, without which autophagy won't happen.
Increasing growth hormone, or even IGF-1 for that matter in an acute fashion which is still in the physiological range wont cause any measurable difference in your lifespan. As said in the video, these effects have not been tested in humans, therefore, we cannot say whether it will or will not increase/decrease our lifespan.
I am personally on MK677 which increases growth hormone. But there are some interesting correlations in human mimicking what is found in mice. They have found people who live longer had lower levels of IGF-1.
Fasting and intense exercises like HIIT increases growth hormone and thus IGF. So does that means they accelerate ageing? But there are numerous studies showing the benefit of exercise and fasting in slowing down ageing by boosting NAD+. So if increased IGF can be equated to increased ageing, how can this be true?
No because those things you mentioned, they're not going to increase your IGF 1 levels to the extent that peptides will. There are already studies that have been done on humans with peptides and IGF 1 level increases. Naturally increasing your levels with exercise and diet is not going to get it anywhere near the levels that peptides will get them at.
new studies showing mice that fast live the same '' extended'' life as the calorie restricted ones... yet fasting also increases growth hormones. so i guess you can get the growth hormone benefits AND longtivity benefits with fasting
IGF-1 is not the sole link to cancer, they recently studied a breed of cattle that had lower incidence of cancer with higher genetic igf1 levels than the normal control group. This led the researchers to look into the mechanisms more closely and agree that they don't understand the biological mechanism for the tumor cell suppression in the high igf1 group but they can definitely attest that it is a novel discovery and directly contradicts current nomenclature.
light a candle. The light and warmth is good. Now light one next to it at both ends. See which one lasts longer. Actually studies have shown it's igf-1 produced by consumption of animal products that is bad, not so much the igf-1 itself. As she says, go for high'ish igf-1, through intense exercise and plants.
I've heard Sinclair say, long periods of TRF, and once in a whole 24-48 water fasts can activate sirtuins, so one could still make gains (AKA eat calories, if TRF, say under 8 hours). Would you agree that one could have both, longetivty and muscle growth (comes with eating calories), if one practices TRF and fasts.
Gosh, I just found this video for the first time, and what a great video it is! Straight to the point. Great thing for me this is what I'm doing already: HIT at the gym, and lots of blueberries & greens, ... and home-made blueberry+blue grape wine. One issue that's missing, I feel, is results of GH/IGF-1 at normal, high AND low levels, as opposed to high versus low only; because having a big GH injection once a week to try to become the hulk is one thing, but just taking melatonin, GABA and arginine at night so as to get a good night sleep and recover your lost normal GH production is quite another.
it may be confusing for some people okay let me explain, if you boost growth hormone then it regenerates your body faster, now each time our body regenerates its telomere gets shorter by reducing our lifespan, now in fasting you get into survival stage where your body keeps its cells protected against oxidative damage thereby making it less necessary to repair!! it also boosts growth hormone level to fix previous damages which will not reduce your lifespan as much. So my suggestion is to not take growth hormone rather do exercise and sprouting which will lead you to longevity.
@K. C. W Just shut the fock up biitch, you have way too much time to spend here bickering so obviously your opinion as well as your life aren't worth shiit.
@@sirwalksoftly correct. So did lewis terman's research. When you listen to what she says what you will notice is.tjat most of it is proof of concept or hypothesis. Also making vague statements like infertility low libido etc is a conditionless claim because it doesn't say what conditions caused lower igf 1. Is it because of chemo that their igf 1 was low? Was the study.done on humans? Was it a genetic defect of some sort? Was it due to extremely sedentary behavior? The statements she made asks more questions than it answers.
It's a good question. We don't really have any evidence to answer it, but it's my impression that boosting GH through natural means such as intense exercise and sauna will be less of a trade-off than HGH therapy.
2iu GH is fine. All above is where the trade off begins I would probably take 2iu only 3-6 months out of the year. Maybe even year round. But definitely measure IGF-1 levels and make sure all is within 200-300 range. Sauna HIIT and cold showers and get IGF1 measured
@@richpotatothebestg.m.ovegg2599 you can do that with fasting the healthy way exogenous injections are followed by hormonal inbalances that produce alot of disturbances in the body
Yep. A low-carb diet of any kind, especially if ketogenic, will have numerous health benefits. Switching between periods of higher and lower protein might be an effective way of doing this.
It's a typical pattern for much of human evolution. Many hunter-gatherers will gorge on massive amounts of meat and then not eat for days or else go for even longer periods on limited amounts. The whole fast and feast lifestyle.
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60 or 70? lol. Try dying in your 50s from various diseases that you can get or cancer from raising your IGF 1 levels for a long period of time, lol. A person would be lucky to live to a healthy 70 just living a normal life with diet and exercise.
What is the better choice? High mTOR from time to time? Or low MTOR, and more autophagy? As I understand it for example, will black coffee boost autophagy in a fasted state. But it will aboslotely inhibit mTOR and then boost autophagy? What is more beneficial for overall health and for example things like hair growth etc.?
Question here. You said Mice and worms lives are shortened when IGF levels are increased 100 and 1000 fold. In humans IGF would not need to be increased near that much to bring an older person up to the same levels as a healthy young person. I believe I read that a young person in their teens and twenties naturally produce the equivalent of about 2iu’s hgh per day. This drops over time and an older person in their 70’s may only produce the equivalent of a half to 1iu per day. You wouldn’t need to increase that by 100 or 1000 times to get their levels up to a healthy range. 2 to 4 times that amount would be sufficient. Is it possible that hgh therapy or using a secretagog like Ibutamoren could bring a person up to healthy levels without shortening their life? Pro Body builders only take 8-15iu’s per day of synthetic HGH. That’s only 4 to 8 times the natural levels of a young person. I imagine if you took 100 times the natural level of HGH it would be devastating to your health. Isn’t that exactly what was done to the mice and worms? No wonder they died quickly. Maybe I’m missing something. I’m open to correction on this.
hoghogwild More like it’s based on my assumption that what I read saying it produces 2iu per day is correct. I’ll have to look for where I read that. I’ve read so much while studying this topic. It’s hard to know if what I’m reading and watching is true. I’ll admit, the 2iu per day figure may be wrong but I did read that not long ago. When I contacted an anti-aging doctor/clinic they told me they will prescribe 2iu’s per day of synthetic GH to bring people up to normal levels. Based on that alone I tend to believe what I read is correct.
They've already made recent studies that looked at thousands of people and found that people that had abnormal increases in IGF 1 levels were living shorter life spans compared to those that had avg or lower IGF 1 levels. A greater amount people with IGF 1 levels in that study also had cancers. There are also many Ex pro body builders that are dying from heart disease or now have diseases that may kill them or lead to shorter lifespan.
@@robmen1402 Makes sense that Abnormal increases in IGF1 can cause decreased life span. What about people with normal iGF1. The 2iu per day of HGH should result in normal levels of IGF1. Not high IGF1. Also neither HGH nor IGF1 cause heart disease in body builders. Many steroids cause an increase in bad cholesterol. Over years of use that can cause blockage. HGH is not a steroid and does not cause any increase in cholesterol.
@@robmen1402 first off higher IGF-1 ist 99% linked to a omnivore diet including animal products which increase IGF-1 this is widely known fact. This type of IGF1 increase is inflammatory and causes cancer not from synthetic GH supplementation. The key is always being alkaline and “healthy” which means being on a unprocessed natural oil free organic diet. Second: bodybuilders have heart disease because they massively abused hormones and therefore developed left ventricular cardiomyopathies and heart wall stiffness. Clearly induced from supraphysiological abuse of Hormones and not comparable to anyone taking hormone replacement levels of testosterone or slightly above that. Lastly on the cancer have you ever heard any bodybuilders dying from cancer? Synthetic GH does not cause cancer. Unhealthy inflammatory lifestyle does
HI Dr Rhonda Patrick. Since this video is already five years old you may not check to see this comment but if you want to look into MTOR you might see the next stage on it not leading to cancer.
A little fast-paced, but insanely useful and great video. Great to see some scientific applicability to increasing fitness, coming from a source that's not a gym-bro
What do you think about Creatine? It's said to increase IGF-1 and inhibit myostatin, but too much IGF-1 sounds risky. I can't find how much it increases IGF-1 as compared to taking an IGF-1 supplement.
You are so good in explaining reasons behind this & that... Thank you for your insights... it really helps laymen who can understands basic complexity of human health.
Great information....kinda sucks though. I use to be able to exercise till I had more energy, it was the weirdest thing and I loved it! Now I dont want to get out of my chair. That was in 6 months. I had a Clean diet and exercised for years....I thought I could blow off the ageing process. 'Age' is a immovable somebeeach. It has other plans for me. Not clear on what to do at all to make this better. : (
What about a life strategy of putting on massive muscle in youth when one is at prime health and immune function then in later life phases go into a muscle sustainment strategy that is lower total stress. I suspect that there's an optimum "formula" for balancing grown, recovery, reproduction capacity and longevity based on TIME/AGE. In other words as one gets older we can presume that they have many impaired functions - reduce telomere protective end caps on DNA, wear and tear of "life" in general from oxidative stress, toxin build up in live and body-fat due to accumulated ingestion and exposure of toxins in food and atmosphere/environment etc. At some point, as a person ages, if one wants to optimize "longevity", presuming that they have started off with excellent LBM in youth and low body fat then a good strategy would be to "coast" on the momentum of that muscle put on in youth at a minimal "sustainment" or maintenance level of exercise so a not to over train the body with too intense exercise simultaneous to induce more wear-and-tear and oxidative stress and higher risk to getting a disease (esp Cancer) due to stressed immune and repair systems. Thoughts? Any studies on this risk-reward trade space? This idea comes from the Soma Theory of aging and longevity as it relates to optimizing: Growth, Repair, Reproduction and Longevity.
Yes, very much along the lines of my own thoughts/ideas on the subject. Also (now in my late 40's previously natural bodybuilding advocate) my own personal practice How about autophagy and the theory of occasional three day fasts? So cycling (and taking advantage of) low IGF-1 periods with alternate periods of quality eating, exercise and all other GH promoting activities?
be grateful if someone can explain the confusion here, fasting suppose to decrease cancer risk / inflammation, but it increases HGH and IGF-1, which promote cancer / inflammation risk. Thanks in advance
This video got me thinking. I decided to read the study in question, published by Aging Cell, It appears that the study references "humans" in its conclusion a couple of times while also specifically stating that the lower IGF-1 levels were shown to be beneficial ONLY to women, and there was NO difference for men. Its misleading at best though true with respect to no positive lifespan impact, particularly confusing in the way it has been citied by media as "HGH shows opposite intended effect" (like WSJ, ect). Another study needs to be done examining why the men and women responded differently. Though the study had 75% women, there were close to 200 participants and it seems that there may be differences in how men and women respond to HGH. Its more clear that HGH does nothing to extend lifespan in either men or women, but that's not why people take it. There seems to be an overarching and arguably well intended govt interest in the relation to curbing cancer, thus leading me to believe that this NIH study is being put forth as a "HGH promotes/can increase risk of cancer, therefore bad, period" type of logic. What about the notion that it may have no positive impact on lifespans of men (perhaps negative for those predisposed to cancer), but may have body degeneration prevention benefit, while also showing some negative side effects? The US govt would never fund such a study, correct? onlinelibrary.wiley.com/doi/10.1111/acel.12213/full
The link itself is clear, but what's not crystal clear is practical advice. A person's IGF-1 changes alongside many other chemicals, unlike more controlled mouse studies, so you can't simply say, "Oh, IGF-1 went up. Cancer risk goes up."
@@jlushefski the studies that are done that prove this are in people with genetically low igf 1 they are almost immune to diabetes and cancer. They study ashkenazi jews usually because they are a particularly homogenous group genetically. It helps control for genetic variabilities as much as you practically can. But people with acromegaly are way more.likely to get diabetes and cancer. People with acromegaly could be described as having raised.levels of both igf 1 and hgh. Their over active pituitary releases BOTH of them at a higher rate. www.ncbi.nlm.nih.gov/pmc/articles/PMC4619193/ Acromegaly patients are more prone to cancer [119] [120][121], diabetes [122], and are often short-lived compared to people with normal GH secretion [123,124]. www.researchgate.net/publication/6749030_Cancers_Associated_with_Acromegaly Of course these are two polar opposites and the differences are extreme but the relationship is exactly what you would expect. Go look up acromegaly and see if they are built like Arnold Schwarzenegger or ultra cognitive powerhouse geniuses at the top of the academic tiers of society. (Ps: they aren't)
@@relaxingaudioforchillongou488 That proves a link, which is exactly what I said is clear. The link alone doesn't give us enough insight for definitive practical advice, because there are downstream changes as well as other changes that occur at the same time. Calorie restriction for instance extends lifespan, but calorie restriction alongside methionine restriction, which also extends lifespan, doesn't. Maybe the IGF-1 differences are simply effecting changes that we can manipulate directly, without affecting IGF itself. That's why more research is needed, though there is a good amount in smaller animals.
My father is 77 and has mild-moderate dementia and I am considering hgh and a very low dose of testosterone to help from muscle wasting and osteoporosis.
I'm 69 and worn put. I'd prefer 5 yrs of good/decent life than 10+ yrs of continued sloth life. Quality over quantity IMO. HGHand testosterone for me. Back to my health Dr it's worth the money. Nothing outrageous just not insurance covered. Thanks
At 57 I was starting to feel the affects of aging. I have always been athletic but I was started to feel I needed to be careful in my movements as to not hurt myself, like if I jumped out of bed in the morning too quickly. But, I have been doing intermittent fasting since then and I have never felt better. I will be 60 this week and I am amazed at how good I feel.
yeah HGH would be bad as it is a non-precursor. You want to stimulate the growth hormone in the body that way your body knows how to regulate the ecosystem of hormones, neurotransmitters, etc. It's like a Bodybuilder going shopping for a Gossard Wonder Bra - After he had an Estrogen boost from mainline T and his body said ok better squirt out some O - I have always thought GABA is good to take a look - also reduces stress so there is no trade-off like this woman has mentioned. - Hey I am sure she tries ;)
I am hypo-pituitary and prescribed r-GH therapy 6 yrs ago. My prescription of HGH is $500/mo. after retiring 3 yrs ago I can no longer afford it and the consequences you describe are real and omnipresent with low IGF-1, was 200# now 190#, vitality lacking libido low, exercise ability dramatically reduced, muscle wasting very apparent. That's life.
I honestly don't believe it... I believe GH and IGF can cause longevity. Sylvester Stallone is 70 and looks 45-50. He's in amazing shape & had been known to been abusing GH for years
How about an intermittent fasting based diet and exercise protocol so that we can have our cake and eat it too (Martin Berkhan of LeanGains dot com)? IGF-1 is inhibited during the fast while epinephrine and norepinephrine are increased. This leads to an increased metabolism where fat oxidation is prioritized and cognitive performance is improved. There is also an increase in GH.
I'm going to be writing and probably making a video talking about this as soon as I'm done looking into it. I'd give it a couple of months. In the meantime, sign up for my newsletter so you don't miss it. (It's available on foundmyfitness.com, also linked to on the FMF TH-cam profile.)
It takes a special kind of person to take something like this and make it interesting and simple. Love your videos.
Nobody is increasing their levels as much as she is referencing. Ie she’s a moron
Dr. Rhona I hope this will get your attention: IGF-1 is associated to development and metastasis of cancer, if Sauna use is promotes IGF-1 does it also mean the use of Sauna is also Cancer promoting? and what is the difference of IGF1 from Food and IGF1 caused by Sauna use and Exercise in relation to Cancer?
Intelligent, gifted, and a sweetheart without a big ego. Making difficult subjects more accessible and easy to follow. Years and years of research made understandable for everyone.
Wow! This was in 2013. Meanwhile she's got me growing broccoli spouts in 2021. I'd love to see more content like this.
me too brother n dont forget to take your vitamin D supplement alongwith a glass of milk once every month...60000 IU one capsule
@@kadarsupermarket9223 What is this based on? Why once a month and why such a high dose?
@@horseradishwithchives thats what the docs usually prescribe because most people cant take daily supplements sustematically
I don't agree with what you said at the end of the video. Actually, it's all about pulsivity.. you can pulse IGF-1 from time to time to promote growth in your system, then follow this with a long period of caloric restriction to clear your system, then reperform the cycle, I think that's the secret to a healthy long life, just pulses of growth followed by a period of autophagy..
Exactly my thinking too, great insight. Do you have any other sources you like to watch / listen too I’ve just come across Rhonda & keen to find other great sources
This is a real dilemma, especially past 40. I still think it's worth 3 months in an anabolic state at any age to get the muscle mass up and do everything you can to maintain it. A good interview would be with Dr Sullivan who wrote The Barbell Prescription.
I’m no expert but I believe the healthiest option would be to work out and eat well in order to build muscle.
@@שגהש Yup these guys are all insecure
@@theworkethic no they aren't. They're thoughtful.
It's not a dilemma because her conclusion is false.
@@שגהשyou can only build muscle in a calorie surplus. You are either anabolic or catabolic.
Exercise physiologist here, there is actually no inconclusive date that shows High intensity exercise increases life span (longevity). Actually quite the opposite, slow steady state movement (walking) is the greatest factor for longevity across broad spectrum studies of varied genomes
Great !
I spend 10 -12 hrs in the Gym weekly . . . (resistance training and cardio)
I consume Green Tea and Turmeric daily, and dark chocolate once a week.
My MD says that my physiological age is in the early forties . . . However, I will be 70 in a few months !
I'm glad to see that I am on the right track . . .
Thanks so much for sharing !
Cholesterol, PSA, BP?
Mine are 163, 1.73, and 112/72.............I am 70 years old.
I take no medication for cholesterol or BP or anything else for that matter.
@@europaeuropa3673 Great stats ! Mine: No meds - 157, 1.00, 117/63 . . . . looking to drop my Cholesterol down even more if possible
Yes, calory restriction is not the same thing as eating less often. 💚 I'm 70 and an very pleased with how things are going. #growingyoung
You are absolutely incredible! I have been looking for a clear and concise comparison relationship between IGF-1 and GH. You knocked it out of the park.
I wouldn't say the relationship between longevity, performance, growth factors is super straightforward. There are lots of animal models that don't follow the expected path (I think there are a couple reviews that cover growth hormone/igf-1 manipulations), and there are plenty of other chemicals that affect performance and longevity, making context important.
As far as I've read a hot bath does not elevate the core body temperature as robustly as a 30-60 min. sauna session. It is the intense heat stress that induces a massive rise in GH. My next video is going to be on this topic since there has been significant interest on the effects of sauna. If you've subscribed to my channel, then you should be notified when this video goes live.
FoundMyFitness where’s the video about the sauna
In other videos you said that caloric restriction is good for longevity but in this video you’re advising us to caloric restriction. It’s a bit confusing.
What’s the definition of caloric restriction?
Is intermittently fasting considered caloric restriction?
@@bfharb most confused comment I read in my life
@@bfharb What is confusing in caloric restriction helps longevity vs her advising us to restrict the caloric intake? You can find explanation if you google it. It will probably be the first result. IMO the term can be a bit confusing because it is relative to one's current diet and lifestyle. If one already has optimal caloric intake for current lifestyle (Iron bender probably needs more calories than a guy who spends all day in a chair and occasionally jogs.). Intermittent fasting can definitely help you to restrict/reduce caloric intake.
What about mk667
The information is very much worthwhile. We should be most grateful for someone taking out the time to make this presentation.
I love how fast you speak. It's so relaxing. When people speak too slowly for me I get agitated. I often use the speed up function of youtube for that reason. Please keep up the tempo, I'm loving it.
Is she talking fast? I thought the opposite lol
Slightly fast
This is possibly one of the best videos on any supplement I've seen. Straight to the point.
This is great, thank you for putting together a concise, content-rich and evidence based video!
I have been trying to manage my health since my 20 and as I am now 70 years old I feel very blessed. Thank you for your information, it was enlightening because I have been weight training to maintain my muscle mass and trying to increase my IGF-1 to reduce fat storage.
Congrats, you're on the right track. If you haven't already, you might want to check out the Ketogenic diet, which seems to dovetail very nicely with HGH/IGF-1 supplementation.
DYOR on Keto. I strongly disagree with KETO. Oil is a absolut killer. A Keto diet is NOT sustainable it’s only for short term goals such as weight loss which will have a longterm effect. That’s ok. But not Keto longterm
Super smart lady. Glad she's out here putting out knowledge
My gosh I love you!!! 💕 You make physical science so easy to understand!!
Ill tell you something right now considering i do take gh. I know it has reversed aging related issues that i have had as i have aged. In fact i believe some of my hair color has even returned to some extent. Increased healing time from work outs and many other benefits. I am not a mouse worm or fly. I would rather live a higher quality of life regardless rather than live longer and a horrible quality of life. You should really think of this as you age and lay in your death bed.
W o r d
This is so over my head. I think the more I expose myself to these ideas the more it will makes sense to me.
Awesome job Rhonda! It was simple enough, and short enough for my mind to be able to follow and absorb the information. And it gave me good options. Well done.
Your brain is the most beautiful thing I've ever seen in my entire life. It is so full of knowledge!
We're here for a good time, not a long time. Thanks Doc.
🤣🤣🤣 so good
🙏🏼
Hardly. No one increases their GH levels to 100 fold. They don't even increase them 10 fold with gh supplementation.
So her gym only advice for increasing GH is pure stupidity particularly for aging adults who cant recover fast enough to benefit from a "gym only protocol" for gh supplementation. If you're about 45, you MUST supplement gh if you want longevity and quality of life, recovery etc. while exercising at the gym.
Peptide CJC1295 w/dac is the best way to supplement gh. Dont waste your time and health on HGH. There are too many side effects and complications.
@@stephencarlsbad mk677 looks to be good too.
@@stephencarlsbad you can actually increase GH levels 2-10x your natural amount with CJC1295 (peptide) and even further with GHRP secralogues (wrong spelling) and even further with HGH. Plus adding time in the sauna and plenty of sleep and exercise, one can theoretically boost natural GH levels well over 10x the natural amount
I'm watching a video on IGF-1. A topic she knew a lot about 9 years ago.
You can tell she has yelled a lot in her life. She sounds like she's about to explode at someone lol
She looks like she's trying not to lunge at the camera lmao
lol it's so true.
Hi Tomo, is your criticism all you got from this brilliant information about wellness?
Hahhahaahahaa
Neurodivergent. There’s a fine line between yelling and speaking up. The yelling activated my stress response so I only understood about 1/4 of what she was saying. I wish I were kidding, but I’m not. (Really low GH here, hence the hyper-reactive stress response)
Good presentation and direct. Nice job
When starving lab animals every third day , they live twice as long
Since your comment is pretty high I'll throw it in for others to see. This is particularly true for animals, they not only live longer (usually 30%) but are also in WAY better health. The difference is, for humans it seems not to neccessary increase longevity, BUT it reduces the amount of agerelated diseases immensly. So we might actually be old age and strong and healthy. A 5 day waterfast once every 3 months or minimum 2x a year seem to keep the benefits going.
@@Bankai90 Largest ever human experiment with caloric restriction was great depression, result: bump in life expectancy of 6.2 years ur.umich.edu/0910/Oct05_09/19.php
@@ZegaracRobert I would love to learn something new from you 😇 BTW this is true what you wrote :) And it makes sense- less work for the metabolism :)
@Zegarac Robert that study is interesting
I don't know why some answers never pop up for me hah
The thing is, most people would have a hard time to restrict food for several decades without putting too much stress from various sources for in this age. And who wants to live life that restricted let's be honest here haha.
Dr Ronda has another vid here about autophagy and they talk about the same benefits mimicking a calorie restricted life can be gotten through two waterfasts a year.
@Yana Nova Vlogs
it seems to be that what makes us healthy is a mix of short (even intense) stress and a recovery period. That's why prolonged fasting is so great, we give the body the time to heal. Autophagy usually peaks already at 3 days after starting a fast (if we have been in ketosis from the start), If we eat carbs a 6day waterfast would be more appropiate, that's why the 5 day rule seems quite on point.
Autophagy also rids ourselves of senecent cells which just stay in our body and inflame us. Fixes gutbiome so long refeed is good etc.
Aswell every of those natural stressors seems to activate all pathways associated with longevity and health. Cold showers, Sauna, Breath work(hypoxia), exercise.
Better to fast 2x a year, get in ketosis prior the fast. Maybe do 3 keto days earlier. Then do sport and some yoga flow exercises, some days some real stress like ice baths here and there, eat yo greens and enjoy life^^
@@Bankai90 It's interesting because fasting and low insulin levels seem to boost growth hormone levels.
When fasting 20/4, there is no hunger and so no suffering and you know when to poop and no need think about getting foods; Food taste way better this way (GH up due to dopamine up) and I even did a nonsufferingly feeling 30 km. kajak tour in end of fasting once without feeling deprived, but I was really quiet in my mind after that; Nice!
I side with performance. No point in living longer when you can't even remember it at the end.
But what if it is possible to live say 150 and still be active and in good shape both mentally and physically whilst being 120 as today's 60s are? With that logic you are about to reduce half life and also half cognitive excellence. That is huge difference in my opinion. I mean if the typical old person lives to 75 today imagine how much evolving world you would see if u was to double that and live to 150
Like Dallas McCarver only 26
It seems like it's quantity over quality!
Strenuous exercise and consume polyphenols! No regrets. Put down that self neutering needle juice. That’s just evil
Is there a point in remembering it anyway?
Dr. Rhonda Patrick is like that cool teacher everyone wishes to have.
I started drinking green tea daily and eating the leaves for 2 weeks now. Really feel better now! I can even focus more when studying!
MY GOSH! THANK YOU FOR BEING BORN DR.!!
No kidding. She's amazing.
@@Neilazbiker this is misleading advice, and not borne of causative data.
She's.spewing hypotheses left and right.
Give glory to God not humans
A video on IGF-1 that does not mentioned anything related to its effects on cancer in humans, neither the foods that causes it production to increase... could you please comment on that?
This seemed a blatant omission - I’m not sure I understand why it wouldn’t be addressed.
Great to see an independent thinker! You've got a new follower here!
Hi Dr. Patrick,
i´m glad you explained this in Detail. I already heard you elaborate on this in Tim Ferriss Podcast, though it was hard for me to follow. I wasn´t entirely sure, if I got everything right, because of English beeing my second language. Here it was very clear and i´m very happy, i got it right in the first place.
Thanks a lot!
Thomas Hansen
PS: Your voice is fine! And even if it weren´t, your information is too important to miss just because an subjectivly felt inconvenience. Please keep it coming.
There is a correlation between IGF1 and cancer, from what I've read. "Performance" is an artifact of the mating cycle, which, once it is gone, does not wear well on an old body.
anything that makes your body grow can be related to tumors. IGF-1, HGH and the likes too.
In an acidic inflamed body yes. Not in an alkaline body
Thank you, I’m curious as to why this correlation wasn’t addressed, it’s the only reason I have my doctor monitor my IGF-1 levels. It’s not like this is an arcane aspect that can’t be discussed or at least mentioned in a short video.
There is a video with Rhonda on meat in which she explains that higher meat consumption (which drives higher IGF-1) is only correlated with increased mortality in people with other risk factors, like sedentary lifestyle or excessive alcohol consumption. Basically, exercise helps IGF-1 get into the muscles and the brain, where you want it, as opposed to it staying in the blood and causing tumor growth.
You are an absolute badass! Thanks for everything you put up on this channel!!
So how do you feel about supplemental igf-1 for short term boosts in muscle mass increase and adipose decrease?
I'm a body builder and i believe i have so insight here , given i experiment often with igf , fasting , calorie restriction and bulking over the course of years all while collecting my own personal blood work along the way . This is more than guessing in my opinion .im 35 with a ifg of 100 naturally and it has been around that naturally for me since my early 20's. When i fast which is every day for about 16-18 hrs igf 1 has never raised but maybe 10 points if im lucky. When i cut which is on average 5-6 months every year there is maybe a rise in igf 1 by 5 point if im lucky . when i am in a calorie surplus to gain lean mass along with training . ifg1 stays the same which is for about 8 months our of the year. my diet is always well balanced full of fiber . There is nothing in my experince that is going to alter you genetics for a higher igf1 naturally vs taking somthing like a peptide . I take MK 677 and it take me from 100 to 200-230 for IGF. Just like anything else , it should not be abused . At leves of IGF 1 100 or below i feel sluggish , fat gain is easier , Fat storage is around my main organs , brain function is slower , sleep is worse , skin is worse , hair is thinner , the daily need for afternoon coffee , bones and muscles are more ache , just about everyint in life is worse . Just taking the levels to 200 changes all of this for the better . You decide what you want i guess , My thought is just be responsible with it . Get blood work done , optimize your nutrition and exercise.
Thank you. Similar story to yours. 41 years old been taking hormones since 23. Testosterone and GH. I eat unprocessed natural oil free organic foods. Rarely animal products.
I agree with you.
I’ll keep it short. We can share experiences to help us and learn from each other.
I take synthetic GH Somatropin but I have also taken all GHRP GHRH IPAMORELIN CJC 1295 with or without DAC… etc
Testosteron Never abused just 750 mg Max in my 20s
The past 15 years on TRT 150-200mg week on different injection intervals.
With HCG HMG DHEA AND PREG.
My heart LV ist 12mm and perfect health.
I do HIIT resistance training and Hogg and different interval speeds
Ok to much info possibly but just fyi
Well said Mike.
Do you do this because of height? MK 677 is usually used for that. Actually how tall are you if you don't mind me asking
"All of these things will make you feel like you are living longer, which in this case is a bad thing because you actually live longer." Living longer is good even if I lived in these conditions, which would give me more time to find the way to get everything at the same time.
Hot yoga is a winner. Next article/video on hyperthermia going to be released very soon.
Twarking would make things really hot to. Sori couldn't help my self. Lol
You make so much sense, I’m blown away by your explanation 👍
So, fasting, for example intermittent fasting or warrior diet, suppose to extend your lifespan and increase lean body mass due to higher release of growth hormone, but you are saying that increased growth hormone decreases lifespan and muscle mass. I am confused. Could someone explain, please?
Fasting repairs cells by autophagy. It increases lean body mass by the release of growth hormone. Severe caloric restriction decreases muscle mass and increases lifespan in part by limiting growth hormone production and metabolism. Do not confuse fasting with chronic caloric restriction.
She just explained that more growth hormone your body produces = less expression of stress resistant genes that protect your cells from damage over time. Less growth hormone = more expression of stress resistant genes that protect your cells from damage over time. However eating those polyphenols and a healthy diet can enable those genes that protect your body from stress even while you produce high levels of growth hormones, therefore countering the negative effects of growth hormone (negative effect being more GH = less expression of stress resistant genes that protect your body over your lifespan and lead to shorter life).
intermittent fasting increases the expression of the stress resistant genes by quite a bit, possibly offsetting the increase in igf-1. What I've seen is that it tends to do more than that and offer a net benefit.
As far as I read, fasting increases GH, but not IGF-1, which is what decreases longevity.
Any insignificant and temporary increases in GH from fasting has absolutely no effect on hypertrophy, so that's partly why you're confused. Practical significance is the important lesson here...
Every kid thinking of cheating the system of gains should watch this. Fair and honest.
You should update this video with some of the new resarch. Some the work by Valter Longo looks very promising.
Looks like she took you up on that.
th-cam.com/video/d6PyyatqJSE/w-d-xo.html
I agree. This information should be updated. What about ketogenic diet?
Watch newer vids people ;)
@@henryg3313 These days, it's not just for epilepsy.
@@sinestatus Yeah, what about the ketogenic diet? As with calorie restriction and fasting, the ketogenic diet of course causes ketosis. And ketosis causes autophagy. So all of these methods will improve both health and lifespan, except in studies when autophagy is blocked. The key mediator appears to be ketosis, without which autophagy won't happen.
Very good video, and also a very good way to talk about science with simple words about the mechanisms of GH and IGF1.
Increasing growth hormone, or even IGF-1 for that matter in an acute fashion which is still in the physiological range wont cause any measurable difference in your lifespan. As said in the video, these effects have not been tested in humans, therefore, we cannot say whether it will or will not increase/decrease our lifespan.
I am personally on MK677 which increases growth hormone. But there are some interesting correlations in human mimicking what is found in mice. They have found people who live longer had lower levels of IGF-1.
Fasting and intense exercises like HIIT increases growth hormone and thus IGF. So does that means they accelerate ageing? But there are numerous studies showing the benefit of exercise and fasting in slowing down ageing by boosting NAD+. So if increased IGF can be equated to increased ageing, how can this be true?
No because those things you mentioned, they're not going to increase your IGF 1 levels to the extent that peptides will. There are already studies that have been done on humans with peptides and IGF 1 level increases. Naturally increasing your levels with exercise and diet is not going to get it anywhere near the levels that peptides will get them at.
new studies showing mice that fast live the same '' extended'' life as the calorie restricted ones... yet fasting also increases growth hormones. so i guess you can get the growth hormone benefits AND longtivity benefits with fasting
As the author of the Carb Cycling Diet, which alternates between anabolism and catabolism, I totally agree.
I wonder if there’s a difference between the effects of these hormones when produced endogenously vs. taken exogenously...
IGF-1 is not the sole link to cancer, they recently studied a breed of cattle that had lower incidence of cancer with higher genetic igf1 levels than the normal control group.
This led the researchers to look into the mechanisms more closely and agree that they don't understand the biological mechanism for the tumor cell suppression in the high igf1 group but they can definitely attest that it is a novel discovery and directly contradicts current nomenclature.
Powerful info Dr. Patrick.
Thank you! Glad you enjoyed the video
How could IGF 1 both cause rejuvenation & regeneration, yet cut your life short?
light a candle. The light and warmth is good. Now light one next to it at both ends. See which one lasts longer.
Actually studies have shown it's igf-1 produced by consumption of animal products that is bad, not so much the igf-1 itself. As she says, go for high'ish igf-1, through intense exercise and plants.
Well said. Thanks Dr. Patrick for all your videos.
Glad you learned something!
I've heard Sinclair say, long periods of TRF, and once in a whole 24-48 water fasts can activate sirtuins, so one could still make gains (AKA eat calories, if TRF, say under 8 hours). Would you agree that one could have both, longetivty and muscle growth (comes with eating calories), if one practices TRF and fasts.
Gosh, I just found this video for the first time, and what a great video it is! Straight to the point. Great thing for me this is what I'm doing already: HIT at the gym, and lots of blueberries & greens, ... and home-made blueberry+blue grape wine. One issue that's missing, I feel, is results of GH/IGF-1 at normal, high AND low levels, as opposed to high versus low only; because having a big GH injection once a week to try to become the hulk is one thing, but just taking melatonin, GABA and arginine at night so as to get a good night sleep and recover your lost normal GH production is quite another.
it may be confusing for some people okay let me explain, if you boost growth hormone then it regenerates your body faster, now each time our body regenerates its telomere gets shorter by reducing our lifespan, now in fasting you get into survival stage where your body keeps its cells protected against oxidative damage thereby making it less necessary to repair!! it also boosts growth hormone level to fix previous damages which will not reduce your lifespan as much. So my suggestion is to not take growth hormone rather do exercise and sprouting which will lead you to longevity.
Would it help speed up the recovery process after acl surgery ? And would it also cause heart or organ enlargement ?
Why not go heavy on IGF-1 and combine it with an aggressive fasting regimen?
Take Epitalon wich makes your telomares longer again :p
Is it possible for you to point me to where you learned this a study perhaps. I am very interested in this topic thanks
What do you mean by sprouting? Do you mean fasting alongside exercises
Knowing all these small subtle tricks give you the best of both worlds.
Appreciate the information Dr. Patrick and love your recommendation at the very end.
2019, still the same opinion? Just to make sure
J z yeah David Sinclair’s research seems to state the opposite of this video’s message.
@K. C. W Just shut the fock up biitch, you have way too much time to spend here bickering so obviously your opinion as well as your life aren't worth shiit.
@K. C. W of you do so you won't come to the conclusions Rhonda makes so long as you look at ALL the data.
@@sirwalksoftly correct. So did lewis terman's research.
When you listen to what she says what you will notice is.tjat most of it is proof of concept or hypothesis.
Also making vague statements like infertility low libido etc is a conditionless claim because it doesn't say what conditions caused lower igf 1. Is it because of chemo that their igf 1 was low? Was the study.done on humans? Was it a genetic defect of some sort? Was it due to extremely sedentary behavior?
The statements she made asks more questions than it answers.
Never was an opinion based on conclusions. Not really opinions here,.more like hypotheses.
It's a good question. We don't really have any evidence to answer it, but it's my impression that boosting GH through natural means such as intense exercise and sauna will be less of a trade-off than HGH therapy.
2iu GH is fine. All above is where the trade off begins
I would probably take 2iu only 3-6 months out of the year.
Maybe even year round. But definitely measure IGF-1 levels and make sure all is within 200-300 range.
Sauna HIIT and cold showers and get IGF1 measured
Would a cycle of high protein diet + excercise followed by intermittent fasting give you the best of both worlds?
Yeah bullshit. You can elevate the level od gh or igf1 infinitly with exogenous use, the body can't do that.
@@richpotatothebestg.m.ovegg2599 you can do that with fasting the healthy way exogenous injections are followed by hormonal inbalances that produce alot of disturbances in the body
Yep. A low-carb diet of any kind, especially if ketogenic, will have numerous health benefits. Switching between periods of higher and lower protein might be an effective way of doing this.
It's a typical pattern for much of human evolution. Many hunter-gatherers will gorge on massive amounts of meat and then not eat for days or else go for even longer periods on limited amounts. The whole fast and feast lifestyle.
@@MarmaladeINFP just badass!
started your smoothie for the first time today and I have to say I think its going to change my life i plan on drinking one a day
I really liked this video! just subscribed.
Thank you! Also consider checking out my email newsletter. I send out articles that accompany the videos sometimes on there. See foundmyfitness.com for more info.
Intense exercise and brightly colored foods. Got it
WE are what WE ABSORB
Make IT a great story my FRIENDs
So live long and be incapable mentally and physically or live 60/70 years and be much more capable ?
I know what I would pick
Live as long as possible, so better technology comes and we reach singularity and then never die?
60 or 70? lol. Try dying in your 50s from various diseases that you can get or cancer from raising your IGF 1 levels for a long period of time, lol. A person would be lucky to live to a healthy 70 just living a normal life with diet and exercise.
Ask most elderly people with diminished capacities in one aspect or another if they’d rather live longer and I expect very few would say no.
What is the better choice? High mTOR from time to time? Or low MTOR, and more autophagy? As I understand it for example, will black coffee boost autophagy in a fasted state. But it will aboslotely inhibit mTOR and then boost autophagy? What is more beneficial for overall health and for example things like hair growth etc.?
Question here. You said Mice and worms lives are shortened when IGF levels are increased 100 and 1000 fold. In humans IGF would not need to be increased near that much to bring an older person up to the same levels as a healthy young person. I believe I read that a young person in their teens and twenties naturally produce the equivalent of about 2iu’s hgh per day. This drops over time and an older person in their 70’s may only produce the equivalent of a half to 1iu per day. You wouldn’t need to increase that by 100 or 1000 times to get their levels up to a healthy range. 2 to 4 times that amount would be sufficient.
Is it possible that hgh therapy or using a secretagog like Ibutamoren could bring a person up to healthy levels without shortening their life? Pro Body builders only take 8-15iu’s per day of synthetic HGH. That’s only 4 to 8 times the natural levels of a young person. I imagine if you took 100 times the natural level of HGH it would be devastating to your health. Isn’t that exactly what was done to the mice and worms? No wonder they died quickly.
Maybe I’m missing something. I’m open to correction on this.
This is all hinging on your assumption that the human pituitary gland expresses 2IU(0.666mg) of hGH/day.
hoghogwild
More like it’s based on my assumption that what I read saying it produces 2iu per day is correct. I’ll have to look for where I read that. I’ve read so much while studying this topic. It’s hard to know if what I’m reading and watching is true. I’ll admit, the 2iu per day figure may be wrong but I did read that not long ago. When I contacted an anti-aging doctor/clinic they told me they will prescribe 2iu’s per day of synthetic GH to bring people up to normal levels. Based on that alone I tend to believe what I read is correct.
They've already made recent studies that looked at thousands of people and found that people that had abnormal increases in IGF 1 levels were living shorter life spans compared to those that had avg or lower IGF 1 levels. A greater amount people with IGF 1 levels in that study also had cancers. There are also many Ex pro body builders that are dying from heart disease or now have diseases that may kill them or lead to shorter lifespan.
@@robmen1402
Makes sense that Abnormal increases in IGF1 can cause decreased life span. What about people with normal iGF1. The 2iu per day of HGH should result in normal levels of IGF1. Not high IGF1. Also neither HGH nor IGF1 cause heart disease in body builders. Many steroids cause an increase in bad cholesterol. Over years of use that can cause blockage. HGH is not a steroid and does not cause any increase in cholesterol.
@@robmen1402 first off higher IGF-1 ist 99% linked to a omnivore diet including animal products which increase IGF-1 this is widely known fact. This type of IGF1 increase is inflammatory and causes cancer not from synthetic GH supplementation.
The key is always being alkaline and “healthy” which means being on a unprocessed natural oil free organic diet.
Second: bodybuilders have heart disease because they massively abused hormones and therefore developed left ventricular cardiomyopathies and heart wall stiffness. Clearly induced from supraphysiological abuse of Hormones and not comparable to anyone taking hormone replacement levels of testosterone or slightly above that.
Lastly on the cancer have you ever heard any bodybuilders dying from cancer? Synthetic GH does not cause cancer. Unhealthy inflammatory lifestyle does
HI Dr Rhonda Patrick. Since this video is already five years old you may not check to see this comment but if you want to look into MTOR you might see the next stage on it not leading to cancer.
A little fast-paced, but insanely useful and great video. Great to see some scientific applicability to increasing fitness, coming from a source that's not a gym-bro
What do you think about Creatine? It's said to increase IGF-1 and inhibit myostatin, but too much IGF-1 sounds risky. I can't find how much it increases IGF-1 as compared to taking an IGF-1 supplement.
IGF-1 supplement ..... IGF-1 has a low oral bioavailability just pin it. Creatine increases your production of ATP like 5% or less.
You are so good in explaining reasons behind this & that...
Thank you for your insights... it really helps laymen who can understands basic complexity of human health.
" Laypeople" 🤣🤣🗣🤛🏽
Great information....kinda sucks though. I use to be able to exercise till I had more energy, it was the weirdest thing and I loved it! Now I dont want to get out of my chair. That was in 6 months. I had a Clean diet and exercised for years....I thought I could blow off the ageing process. 'Age' is a immovable somebeeach. It has other plans for me. Not clear on what to do at all to make this better. : (
Good video - simple and to the point. Maybe a more relaxed speech?
Such a good chsnnel
Dr Rhonda Patrick is my fav
What about a life strategy of putting on massive muscle in youth when one is at prime health and immune function then in later life phases go into a muscle sustainment strategy that is lower total stress. I suspect that there's an optimum "formula" for balancing grown, recovery, reproduction capacity and longevity based on TIME/AGE. In other words as one gets older we can presume that they have many impaired functions - reduce telomere protective end caps on DNA, wear and tear of "life" in general from oxidative stress, toxin build up in live and body-fat due to accumulated ingestion and exposure of toxins in food and atmosphere/environment etc. At some point, as a person ages, if one wants to optimize "longevity", presuming that they have started off with excellent LBM in youth and low body fat then a good strategy would be to "coast" on the momentum of that muscle put on in youth at a minimal "sustainment" or maintenance level of exercise so a not to over train the body with too intense exercise simultaneous to induce more wear-and-tear and oxidative stress and higher risk to getting a disease (esp Cancer) due to stressed immune and repair systems. Thoughts? Any studies on this risk-reward trade space? This idea comes from the Soma Theory of aging and longevity as it relates to optimizing: Growth, Repair, Reproduction and Longevity.
Yes, very much along the lines of my own thoughts/ideas on the subject. Also (now in my late 40's previously natural bodybuilding advocate) my own personal practice
How about autophagy and the theory of occasional three day fasts? So cycling (and taking advantage of) low IGF-1 periods with alternate periods of quality eating, exercise and all other GH promoting activities?
This is the natural bodybuilders dilemma isnt it? We want performance but later (usually 40's) we start to see the other side of the curtain.
@@colingibson8930 consecutive fasting days are bad but if you space them out you promote autophagy whilst avoiding muscle atrophy
be grateful if someone can explain the confusion here, fasting suppose to decrease cancer risk / inflammation, but it increases HGH and IGF-1, which promote cancer / inflammation risk. Thanks in advance
This video got me thinking. I decided to read the study in question, published by Aging Cell, It appears that the study references "humans" in its conclusion a couple of times while also specifically stating that the lower IGF-1 levels were shown to be beneficial ONLY to women, and there was NO difference for men. Its misleading at best though true with respect to no positive lifespan impact, particularly confusing in the way it has been citied by media as "HGH shows opposite intended effect" (like WSJ, ect). Another study needs to be done examining why the men and women responded differently. Though the study had 75% women, there were close to 200 participants and it seems that there may be differences in how men and women respond to HGH. Its more clear that HGH does nothing to extend lifespan in either men or women, but that's not why people take it. There seems to be an overarching and arguably well intended govt interest in the relation to curbing cancer, thus leading me to believe that this NIH study is being put forth as a "HGH promotes/can increase risk of cancer, therefore bad, period" type of logic. What about the notion that it may have no positive impact on lifespans of men (perhaps negative for those predisposed to cancer), but may have body degeneration prevention benefit, while also showing some negative side effects? The US govt would never fund such a study, correct? onlinelibrary.wiley.com/doi/10.1111/acel.12213/full
My boy, studies have shown that IGF 1 levels that are too high INCREASES the chances of a shortened life span. That's your answer.
I'm going to the gym now and gonna tell mice, worms and flies all this!
I love that direct advice!
Dr. Patrick, how reliable is the research showing a link between increased levels of IGF-1 and cancer?
Shikhar Chauhan 99%
The link itself is clear, but what's not crystal clear is practical advice. A person's IGF-1 changes alongside many other chemicals, unlike more controlled mouse studies, so you can't simply say, "Oh, IGF-1 went up. Cancer risk goes up."
Very
@@jlushefski the studies that are done that prove this are in people with genetically low igf 1 they are almost immune to diabetes and cancer. They study ashkenazi jews usually because they are a particularly homogenous group genetically. It helps control for genetic variabilities as much as you practically can.
But people with acromegaly are way more.likely to get diabetes and cancer.
People with acromegaly could be described as having raised.levels of both igf 1 and hgh. Their over active pituitary releases BOTH of them at a higher rate.
www.ncbi.nlm.nih.gov/pmc/articles/PMC4619193/
Acromegaly patients are more prone to cancer [119] [120][121], diabetes [122], and are often short-lived compared to people with normal GH secretion [123,124].
www.researchgate.net/publication/6749030_Cancers_Associated_with_Acromegaly
Of course these are two polar opposites and the differences are extreme but the relationship is exactly what you would expect.
Go look up acromegaly and see if they are built like Arnold Schwarzenegger or ultra cognitive powerhouse geniuses at the top of the academic tiers of society.
(Ps: they aren't)
@@relaxingaudioforchillongou488 That proves a link, which is exactly what I said is clear. The link alone doesn't give us enough insight for definitive practical advice, because there are downstream changes as well as other changes that occur at the same time. Calorie restriction for instance extends lifespan, but calorie restriction alongside methionine restriction, which also extends lifespan, doesn't. Maybe the IGF-1 differences are simply effecting changes that we can manipulate directly, without affecting IGF itself. That's why more research is needed, though there is a good amount in smaller animals.
I periodically take TA-165 to boost HGH. I feel and look 100% better. What are your thoughts about cancer with taking HGH or HGH boosters?
I thought that fasting increased HGH and reduced IGF1 and stimulated neurogenesis.
My father is 77 and has mild-moderate dementia and I am considering hgh and a very low dose of testosterone to help from muscle wasting and osteoporosis.
I'm 69 and worn put. I'd prefer 5 yrs of good/decent life than 10+ yrs of continued sloth life. Quality over quantity IMO. HGHand testosterone for me. Back to my health Dr it's worth the money. Nothing outrageous just not insurance covered. Thanks
where do you get it
On the right track.
At 57 I was starting to feel the affects of aging. I have always been athletic but I was started to feel I needed to be careful in my movements as to not hurt myself, like if I jumped out of bed in the morning too quickly. But, I have been doing intermittent fasting since then and I have never felt better. I will be 60 this week and I am amazed at how good I feel.
yeah HGH would be bad as it is a non-precursor. You want to stimulate the growth hormone in the body that way your body knows how to regulate the ecosystem of hormones, neurotransmitters, etc. It's like a Bodybuilder going shopping for a Gossard Wonder Bra - After he had an Estrogen boost from mainline T and his body said ok better squirt out some O - I have always thought GABA is good to take a look - also reduces stress so there is no trade-off like this woman has mentioned. - Hey I am sure she tries ;)
Thank you for sharing and the advice at the end. Very apprechiated.
Thank you! Make sure to check out my newsletter -- I often release articles to accompany these videos on there.
We all end up in the same place.....Quality over quantity.
You don't know where we end ;) 😀
@@YanaNova The place where they keep all those dead bodies
I am hypo-pituitary and prescribed r-GH therapy 6 yrs ago. My prescription of HGH is $500/mo. after retiring 3 yrs ago I can no longer afford it and the consequences you describe are real and omnipresent with low IGF-1, was 200# now 190#, vitality lacking libido low, exercise ability dramatically reduced, muscle wasting very apparent. That's life.
Do fasting. It has shown to increase growth hormone. Do intermittent fasting.
loved you on joe rogan didn't know you had your own channel subscribed instantly
it is rare to hear the disadvantage of caloric restriction (different from nutrients restriction)
Sauna increasing growth hormone levels. That's something that deserves digging into.
How bout infrared
james_gats you’re 6 years late
Really good video Dr giving both sides of the story !
I love this chick. She is hot and smart!!
If only she knew how to pronounce Turmeric.
@@juliantreidiii lmfao
tom cats Bada Bing.
Smart but not hot
What about chuckling? That ending gave me a good chuckle. Thanks for your work.
I honestly don't believe it... I believe GH and IGF can cause longevity. Sylvester Stallone is 70 and looks 45-50. He's in amazing shape & had been known to been abusing GH for years
Sample size of one
People with Laron Syndrome is a bigger sample size. They are IGF-1 deficient and never die of cancer.
nice anecdotal evidence
Right, miracle drugs that threaten the profits of pharmacies, hence the propaganda
Simply put astonishing. I've subscribed.
How about an intermittent fasting based diet and exercise protocol so that we can have our cake and eat it too (Martin Berkhan of LeanGains dot com)? IGF-1 is inhibited during the fast while epinephrine and norepinephrine are increased. This leads to an increased metabolism where fat oxidation is prioritized and cognitive performance is improved. There is also an increase in GH.
I'm going to be writing and probably making a video talking about this as soon as I'm done looking into it. I'd give it a couple of months. In the meantime, sign up for my newsletter so you don't miss it. (It's available on foundmyfitness.com, also linked to on the FMF TH-cam profile.)
Or not eat while you're intermittent fasting.😉
No BS. Love her
I like these videos very much so interesting too me. :)
I do a lot of research on CR and have been doing it myself for over 10 years. :)
Matt, Fancy meeting you on this video. haha
excellent. time to hit them HGH and green tea. haha.