Growth Hormone 101: What it is, where it comes from, and what it does | Peter Attia & Derek MPMD
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- เผยแพร่เมื่อ 28 ส.ค. 2024
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This clip is from episode 274 - Performance-enhancing drugs and hormones-risks, rewards, & broader implications for the public
In this episode, Peter is joined by Derek, the entrepreneur behind @MorePlatesMoreDates and an expert in molecules commonly used and misused by bodybuilders and athletes.
In this clip, we discuss:
- What Growth Hormone is
- Is it truly the elixir of life?
- How to dose Growth Hormone
- If you take GH, does your body quit producing it?
- And more
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About:
The Peter Attia Drive is a deep-dive podcast focusing on maximizing longevity, and all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, and much more.
Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan and simultaneously improving their healthspan.
Learn more: peterattiamd.com
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A lot of hate on the guest for no reason. First of all you don’t need a degree to be knowledgeable on a subject. This guy is on the show because he has read and understands the literature on the subject AND has personal experience using it himself. None of y’all bat an eye when popular bodybuilders spew nonsense on their channels based on their opinion. This guy actual read the academic literature. Secondary they stated many times how this particular subject lacks research. This means Peter wouldn’t likely find a researcher on this subject because they don’t really exist. This was a very insightful show.
Exactly 👏
Yep, so many people thinking they're being smart but are using a common logical fallacy called 'appeal to authority' ridiculous lol.
100% correct
Derek is crazy knowledgeable on all facets of hormone optimisation…. I’d easily listen to him over my family GP. Who is restricted by a 6 minute window to get me in, get me prescribed then get me out…..
Why do you think doctors are utilizing his knowledge. Doctors know zero about steroids or other supplements. Doctors are terrified of steroids
62 yo with destroyed shoulder, thought I'd have to live with it. Got on HgH, takes about 6 mo for real results. 1 year later my shoulder is 100% like I was 29. Miracle compound
Thanks for sharing. What do you mean by destroyed shoulder? My moms shoulder was shattered in a fall last year - doubt she would fast but wondering if this could help her
Impressive. How many units per day did you take?
And did you experience any side effects?😊
thats probably because it healed during that time buddy
depends a lot on your endogenous production of VEGF. there is a lot of dietary choices that affect angiogenesis.
If ur taking HGH for injury, u will want to be mindful of your VEGF levels as well. They work hand-in-hand to increase collagen repair rates, which does the magic in restoring injuries.
What did you take for hgh? peptides?
How fucking amazing is it that Derek with no formal education on this stuff is answering questions for Peter Attia who is already an absolute monster in the longevity space. The world is righting itself.
Peter Attia repeats bro science
@@juicebox853Don't you have a 10th booster clot shot to take?
@@Jimbo-fv4eknice lol
Gah I'm an American docterrrr, look at me I read from a script
Derek's knowledge on this stuff is crazy.
Derek is smart, but he knows far less than Peter. You can tell when Peter asks him questions it's purely rhetorical. Peter understands the biochemistry and endocrinology to a far greater extent. Love Derek though, he's the man.
@@Billybear185 does he? not every doctor is an expert in every area. i have a guy in my cricket team is one of the most respected doctors in sydney and he isnt an expert in this at all
@@Billybear185 Derek knows more about the use of drugs in bodybuilding though.
@@richardhurr31 that's probably true.
@@Billybear185it is true
Great podcast....In my early 30's I was in a near death accident. I broke my C1,2,3 L3,4,5 and had a TBI. I was paralyzed from the neck down for 4 months & was told I would never walk again. At the time I walked around at 185 and was in great shape. I could not eat or drink and went down to 138. Had a 14 hour surgery and thank God was mobile. I had a halo, girdle and neck brace. Docs put me on pharmaceutical grade GH because they wanted the bone to grow very fast over the titanium to prevent any additional setbacks. Could not work out at all afterwards. Once home my weight went up to about 160 just from eating again. Got all of the apparatus off. Went to outside family function for a bbq/pool party. It was a hot day- about 95 degrees. Took off my shirt for the 1st time and I was shredded...lol. Went back to the doc when I went back to the gym and asked him for another dose...lmao. The co-pay was $5 on about a $1,200 script, I believe. I got a resounding never ...lmao. The shit works wonders.
yo it heal you 100%?
Captain…yes it did. Great surgeons obviously. I’m not nearly 100%, but I can walk. Ty & merry Christmas
ty. so hgh help a lot?
@@CaptainFalcon yeah bro. hgh made my weiner from below average to well over 7 inches the only issue now is it bulges out like crazy and if i go commando in basketball shorts it looks like i have a chub and it flies alround everywhere
Happy to hear you got your health back. Congratulations, nice to hear happy endings.
00:00 What is growth hormone? (HGH 101)
03:47 What is the relationship between HGH and IGF in the Liver? How do we measure the concentration of HGH in the body?
04:57 If IGF-1 promotes fat storage and HGH promotes Lipid breakdown, shouldn't they be at odds with each other, how does one become more dominant?
06:32 As part of HRT (hormone-replacement therapy), how do people determine the appropriate dosage of HGH that they need?
09:21 What happens to the signalling from the hypothalamus to the pituitary gland to produce endogenous (in-house) HGH when external HGH is given to the body?
12:13 If a person takes exogenous (external) HGH, how long would they have to take it before they compromise their own ability to produce the hormone (even after they quit)?
14:21 The use of HGH in restoration of tissue during periods of healing and orthopaedic injuries.
Late 40s and 4-5mo into 1iu/day and I am speechless on how good I look, feel, think, workout but above that the moods are so incredible it’s surreal. I hadn’t felt like this in 15yrs of aging. I have zero family cancers and get bloodwork every 4mo to monitor
Good for you 💪🏽do you use also trt with that?
@@crazyfacts5126 yup androgel. Keeps me at 800ish nothing unhealthy. Tried injections but while it makes me stronger in gym than the gel I hold a little water on it and the gel is noticeably better for focus+moods and no bloat so I look and feel better. And for context, I’m a 5’11 195lb 10% BF, I lift, boxing train and ride mtn bike for 15yrs so I’ve been into this shit. Better shape than at 25yo
FUN FACT-
1 IU a day would be PLACEBO.
@@yoholmes273 lol There’s no time to explain to you how wrong you are. If you go to the anti aging Dr they’ll often prescribe you .5iu/day and no they’re not selling placebos for a few thousand $ a month. I have like 8 guys on hgh in my gym from 35-70yo and everyone is on 1iu and everyone looks and feels fantastic. But yea it takes 4mo to feel anything and 6+ to feel full effects at that dose
Go to 2 IU for actual difference maker. 1 in morning 1 before bedtime.
Derek is the man. Much respect to both of these gentlemen.
I love listhening to both of them. I am a huge fan. I just wish they would speak more in layman's terms because i get lost in their conversation a lot.
Haha. They speak like they are reading a university essay 🤣 It gets so confusing sometimes
Never thought I'd see this pairing!
Why is the influencer explaining GH to the M.D.?
@@nboss968 good question lol
Derek may as well be an M.D. He's only been a student of all of this for his entire adult life. Not only is Derek an expert, but Peter is trying to reach a broader audience because of Derek's following. It's also a business decision. If you go out and do your own research on a specific topic. And a doctor studies a wider, broader area of study. You'll be able to answer any questions he might have about a specific topic. And he could answer your broad question that stretches to other broader areas. An M.D, doesn't know everything ever. @@nboss968
he may know more@@nboss968
MDs aren't experts in all areas. Derek has been focused on this one area for something like a decade.
I'm a female and was on GH from age 6 till 30. Since health insurance makes it so hard to obtain and it's cost prohibitive I stopped trying. I'm now 43 and seeing all the negative side effects that I think are due to being without it (IGF1 is 22). Mood, mental fog, high cholesterol, etc. I'm going through hoops to get back on it.
There is a lot of good and affordable gh available on the bodybuilding scene, easy to get
Since 6? Dang, did you have a medical condition?
I have to ask... Did you end up growing tall? Or do you think it didn't effect your height?
@@Ryan-wx1bi she did not say she's 6' tall but rather that she started gh at 6 year old
@@LuisRodriguez-xn5ru I know... That's why I asked if it made her taller. Having GH since 6 years old has me curious if it added height
Go to mexico
Great content
I can’t believe he dosen’t have a degree in any of this…he really knows this stuff.
But why, what does a degree do.
I guess nothing…we all know people with degrees that work normal jobs.
You don't need a fatuous degree.
Derek makes doctors look like idiots go to channel more plates more dates he's an absolute genius I call him Dr House
A degree is just creditation that shows ppl u know a certain amount about a particular subject that you learned from literature that already exists ,thats all it is the literature and much more is free out ther to read n learn from with or without the creditation
Everyone can be an expert now a days in any field. I despise people who think they are better simply because they followed the sheeple path of becoming a college grad
Yep. The only thing I don’t do myself, is surgery. Lol, besides that, I’ve rebuilt a car engine from videos on TH-cam.
The Endocrine system is exquisitely sensitive.
But also robust in a healthy male at the same time.
Nah, just pin anything you can when you're young, you'll be fine
@@ironmaiden1236541just like all these bodybuilder we see dropping like flies lol
You called me strong, you called me weak
But still your secrets, I will keep
You took for granted all the times, I never let you down
You stumbled in and bumped your head
If not for me then you'd be dead
I picked you up and put you back on solid ground
If I go crazy, then will you still call me Superman?
If I'm alive and well, will you be there and holding my hand?
I'll keep you by my side with my superhuman might
Kryptonite
The possibility that cancer cells will grow with high GH is scary though.
That possibility isn't all one mechanism bro, you have nothing to worry about as the relative risk is low low low
Educate yourself I just ordered a book on HGH
It's theoretical. But kids who have been on HGH for life because their body doesn't produce it, do not have higher rates of cancer.
@@Brian_Life Because they are replacing it. Here we talk about increasing it
It would have been funny if they listed 'More Plates More Dates' as M.P. M.D. - people would have thought he was a medical doctor for a second 😄
QUESTION: I'm 80, poor, see my doctor only once a year, have congestive heart failure & high bp, but I'm ok on medicine, just weak. Can I safely take GENF 20 PLUS? I've already ordered it. A friend says it does miracles. Don't say ask my doctor. I wanna know what you think or guess.
What about the positive results seen in reversing Thymic involution with HGH?
Great podcast thanks guys!
Was this a job interview?
Great interview.
Great video! Most of the time formal education teaches you the wrong things. I know many doctors who are completely against even TRT. However, if you actually research articles and with correct dosing, TRT with actual HGH, fountain of youth! Now I would recommend not trying GHRP2 unless you have a full pantry and fridge lol.
Yet they are not against drinking and smoking. Funny that. Or not.....
No mention of Greg Fahy’s study?
How do I obtain this stuff? I have no hope of growing any taller at 22 but maybe there's a chance.
🤣 we ain't growing taller dog
What about GH while fasted and proper timing for resistance training?
training while fasted has been dis-proven. No benefit other than calorie restriction
@@dronepocket325no
2:41 Tanya Angus was 20 when developing acromegaly. From 5 feet 8 inches tall she growed to nearly 7ft tall. I guess her epiphysis wasn't fully closed at 20, or the humongous amounts of hgh she experienced somehow softened it up again. In any case - one way to create a human with super physiology could be to start with a child of short-backed stature, use large amounts of hgh at a young age, then shorten the limbs when the person becomes an adult. Ethically desirable? No! Possible? Yes. Somehow I am surprised it haven't been done already.
Very good information
I wish Peter Attia would say if he's ever used it and if so, what he felt or noticed?
Damn. Did not expect Thé gymbro Derrick to come on a podcast with Dr Peter!
Agree.. but I'm glad he did. Obviously a very knowledgeable guy
Who is "Derrick"? 🤔
@@Tritiuminducedfusion The man you are looking at giving advice on Gh
@@Tritiuminducedfusion more plates more dates pod cast
DEREEEKKKKKK
More plates more dates
Hey anyone know if I should take hgh with an ai or am I good running it alone as a 20 yo with open growth plates but also taking to help with an injury❤
I took mk677 @5mg for a few months and never seemed to bounce back. I don't get as hungry now when working out which is annoying
What do u mean u never bounced back? I've been on Ibutamoren for about a month now and i think that's the same thing. I've noticed many benefits
What benefits?
Do you take in the am or before bed? Anyone know? Thinking about starting off with 1.5 iu for a month or so
that's why i wonder how insulin could be used with HGH when IGF! is high then in theory blood sugar will be low. Usually after HGH shot blood sugar will be lower
From what I was told and also prescribed. GH is extremely expensive, like omnitrope. It's 400 dollars for a two week cycle. Peptides like sermoreline will increase grhelin. Oxandrolone is a steroid used specifically to increase igf. The point of increasing igf is to get it to where your igf was as an adolescent/young adult. You ideally want your igf to be like almost 300 ng/ml. Because at that point your susceptibility to DOMS, injury, decreases and your recovery heavily increases. They typically give oxandrolone to patients who have had hard-core surgeries. Same with peptides like bpc-157. My igf is 146 ranging from 96-290. So needs to get a bit higher.
Real Omnitrope is a lot more than $400
100ius is £120 in the UK.
What’s a good place to find common dosage for injuries?
.005mg per kg of bodyweight a day
Does Dr..Attia use 24 hour urinary GH as a proxy of measurement?
I took 2.5 iu I thought I was gonna have a heart attack I felt blood rushing through my chest to my head what does that mean?
A little hard to understand much of the results based info given here, I'm not a biological expert beyond anything layman. Not hating on him, he's very well read, but most people aren't going to understand a lot of this
Can MK 677 , be compared to actual HGH?
So would it be just as well to use MK677 this compound was the only thing that put weight on me including deca while taking deca for 12 weeks I gained about 5 lbs added MK I went to 22 lb gain over 2 weeks ended up in hospital with AFIB I’m good now with no meds anymore but it was a year long recovery I went because I couldn’t walk 15 ft without losing all my breath
derek for Growth Hormone only for fat loss for belly fat is there a super low dose that would work 1IU p day for month???
yes, 1iu is enough for liposis effects. 2 would be optimal for fat loss benefits
@@MattChaussee what’s your views on running gh with test & primo ?
I was thinking of running test & primo for 16 weeks at 150mg Monday , Wednesday & Friday & running hgh at 1-2 iu a day
After 16 weeks continue running test & hgh dropping out the primo
Makes sense 😳
My son was prescribed HGH for growth, at the end of his treatment I had 2 month supply, so I took it upon myself to be a guinea pig as my son’s doc specifically said “stop the shots” on my boy.
Let me tell ya I’ve never been more ripped in my life after those two months. I was able to see my muscle definition and all I could do is smile 😊
Covid came and I got fat! 😞 what a waste 😭
Oh and I tried an underground lab but wasn’t the same result, NOT EVEN CLOSE!!! So I said f that 💩
Sorry for private question, my son also was prescribed hgh, but I have very limited exposure to any other cases to learn from them. Could you please advise how old was your son at the beginning of the treatment and for how long did it last and did it help with growth ?🙏
@@kseniazyablova7914 not a problem at all. He was around 8 or so when we started the treatment and he stopped when he was almost 14
Once puberty starts, then the doctor usually want to end treatment due to benefits being diminished.
I can’t remember exactly how much he was growing but we took a break for 6 months since my son hated to get poked daily. And when we went back to the doctor he had grown EXACTLY 1/2 than when on meds. My son was in the one, percentile for his age and now is 5’5” at 15
I estimate that without the meds he would had been 5 feet tall or less.
Hope this helps and lots of luck with your kiddo
@@kseniazyablova7914how old is your son?
I can tell that you dont lift
@@trashcan6751 I think you can tell 💩! 😆 so you know my entire work out routine in one comment. What a child you are 🤡
The internet 🤦🏻♂️
Why not inject IGF-1 and skip all the conversions?
Price
Igf1 is less effective, more taxing on the liver, & more cost prohibitive.
@@yoholmes273 Igf-1 less effective 😂😂😂 you have no idea
Increlex is the pharma brand $$$
can you please say whole speech again in spanish?
Yes
Opinion on the natural supplement Bio Bro which is suppose to contain IGF 1 🤔
2:55 Peter chill
Does Derek have any education on these topics or an autodidact?
Self taught. It’s astonishing.
@@TallonC as opposed to what? being a closed minded academic? Have you heard of youtube and google? You don't need to spend 100k to learn from a lifeless, acerbic 70 year old re-hash the same convoluted material 40 years in a row at a university, you can learn quicker and easier from people who are actually passionate about what they teach online. Degrees are fatuous as fuck, everyone I know with one is a lifeless drone working 9-5 in the same job for the past 10+ years because they are so limited minded and thought learning stopped with school. The best of us are all self-taught.
@@Sh0n0 to answer your question, he’s self taught as opposed to a formal education. To clarify your misreading of my tone, my answer is sincere, not sarcastic. I’m a huge fan of Derek. His expertise is self evident. One may be an expert without a degree. And one may also have a degree and be no expert.
Hilarious how many people think they teach this stuff in the form of some degree. Also hilarious that people have been brainwashed into believing that a degree is the only way to become an expert.
@@Sh0n0 You're right, my friend. Scientists and professors from clooge base their knowledge on one direction throughout their lives. My dad is a professor, he creates various new technologies, but he is only good at one subject.
I still find self-taught fascinating.
The entire topic of steroids used by athletes is based on today's new procedure. It was the athletes themselves who tried HCG to reverse testicular atrophy during steroid cycles, thanks to them, scientists and endocrinologists now use it in even basic TRT.
Google says HGH can regenerate cartilage. I wonder if it's true. Because my cartilage is damaged in my elbows. Does anybody know if it's true?????
Dream Body Clinic on youtube is the answer to your problems
Very curious of this as well. Have you heard anything on this?
2 intelligent Men 👌 💪💪🇨🇦🍺🍺
Wow, how did Russell Crowe become an expert in HGH? I guess it works, he looks good!
He’s definitely Russell’s kid!😂😂😂😂
Thompson Deborah Young Shirley Martinez Timothy
Does or has peter used HGh?
Give him a dr title
I’m confused can you andogenously administer igf 1 ? I mean pin it?😅
doesnt it also increase cancer risk?
Nobody in my family ever had cancer . I started using GH about ten years ago and now I'm battling two types of cancer
@@Sam-ig4jh truly sorry to hear this :(
@@Sam-ig4jhCap, gh makes cancer cells grow, not appear out of nowhere...
It can help cancer grow. If you have cancer present in the body and take GH you feed the cancer.
There is a correlation between the jab and rising cancer cases. They msm says it's because we get older. Yeah sure..
Thank you for extrapolating all that. I see it's multi factoralish
Miller Christopher Wilson Carol Rodriguez Amy
Derek is one smart mf.
May be irrelevant but how come Derrick’s last name isn’t mentioned ?
*Derek... and relevance?
He goes by Derek MPMD.
It's Cole. Derek Cole
Derek More Plates More Dates
@jonnyloyie389 Yes, it was mentioned 1000 times, genius, we all know.
If you'd like having facts on the outcomes, why aren't you guys supporting the funding of such studies? I mean, these are people's lives you're doing testing of drugs on, so why isn't it part of a drug trial to demostrate safety and outcomes?
Probably because there isn't all kinds of money to go around and thousands of studies people would ideally like to do
They cost 10s of millions nowadays
It is. They give anabolics to surgery patients to increase the retention of lean tissue and burn fat. While also increasing their igf so they recover quicker.
The FDA stops that from happening. Such a corrupt organization
Great clip
Brown Michael Williams Paul Rodriguez Ronald
Wish i understood what the hell Derek is saying ? 😂
Time stamps man..
Go away.
Peter is just a physician 🤣🤣🤣
scientific study proved its not absolute dose of Growth Hormone that can trigger cancer but how quickly a person ramps up dose that can triggers cancer so its not 1IU or 2IU or 4IU or 8IU trigger cancer but how quickly a person ramps up dose to 8IUs no one starts slow and titrates up so question remains if dose is say 2IUs would one do 0.2 for 3 days then 0.4 for 3 days then 0.8 for 3 days then 1.0 for 3 days etc etc until u reached 2IU. does it need to be 3 days or a week or one day trust me its difference between life and death so best do it correctly. problem is it is not exactly known and each person is different can u talk about study proved its not absolute dose of Growth Hormone that can trigger cancer but how quickly a person ramps up dose
Then all pro bodybuilders would be riddled with cancer right ?
Cancer and HGH? Growth Cancer ?
Ofcourse they never talk about side effects. They make money off getting people hooked into these chemicals via their own clinics.
HGH in moderate doses will reduce lifespan, degrade joint tissues, increase likelihood of cancer.
You should’ve named this video HGH 701 lol I can’t understand anything you’re saying 😂
This dude has a Wikipedia degree. Every statement concluded with “I think” or “I could be wrong” which doesn’t make me think he’s qualified to TEACH others on the matter. Regardless of whether people think it’s mean to “hate” on this guy.
He’s clearly no an expert and knowledgable by Wikipedia which is fine unless you’re going around and attempting to teach others and misinforming. Now if they wanting to ask questions and he verify the answers using research, literature, and documents that back his claim that’s fine. Especially if they provide references but to just say “anyone can be smart with out a degree and teach” is the reason why there’s so much bullshit on the internet. Degree or not, you have to provide VALID information. And the reason there is a preference to degree teachers is because they know how to properly reference their information sources. It’s all about providing the people the answer with evidence. Not providing them with “well bro you dial it back and see if it’s average” lol
Where's your degree from?
well.. i find this to be the most useless video/poscast ever! basically you did gave almost no answer on anything… just conjectures, anecdotes, doubs… maybe this, maybe that… 🤷♂️
i don’t know: what is the point of making a video on something you don’t really have clear and founded answers??
Because that's the current level of evidence, very little or no scientific publications, like they mention, it's mainly anecdotal. Plus, it's russian roulette cuz you never know what's actually in the drug from underground labs or from abroad; it's all buyer beware, at your own risk.
its called food for thought. It leads to ideas and future studies. They're just spit balling on this episode. Lol
so there's thing a lot of humans do nowadays known as "discussion"
It’s rare in social media these days to have people who aren’t implying everything they say is fact, and that we need to continue to learn more. It’s actually refreshing when someone says “I don’t know,” when the topics aren’t fully elucidated yet.
@@BrandoTheMando87yes.. i can appreciate a discussion where the partecipants does not present their theory as absolute truth… but with a grain of doubt. That’s appreciable!
but here it’s seems a little bit too high level of doubt: basically it sounds like we have no clue about gh effect!!😄😄
I love when medical professional pretend to be dumb-on-purpose.
The doctor clearly states he utilized the product and his patients saw significant results , yet he calls said results "anecdotal".
Does this Doctor not understand what anecdote means?
FUN FACT- EVERYBODY is on HGH. Yes, your favorite basketball player, football player, soccer player, prowrestler, actor, and even female model is ALL on HGH.
Oh yes, make no mistake, EVERYBODY is on HGH
Every modern professional athlete who has ever torn a muscle has used HGH in their rehab protocol.
Talking bollocks.
This guy is off his marbles
Just stay away from drugs, period
A man of nuance, I see.
Great response, lol
Thanks dad.
Unless you have a medical condition and they're prescribed by a doctor. Oh and caffeine in moderation is OK, and the occasional alcoholic drink. Maybe aspirin or paracetamol for a headache too.
@@richardhurr31no
Who tf is supposed to understand this crap?
Obviously not you
It's wild to me that a hobbyist is brought on instead of an actual scientist... Guess it's good for the views
Bro reads
Ignorance
Guarantee he's more knowledgeable than any endocrinologist. The guy literally hard core studied the subject in depth for 10 years plus
Why, exactly, do you think he there?
The OP is probably someone who thinks that you have to be a scientist to tell the definition of a woman 😂
Listening to these 2 drug dealers tell you everything is safe and great is not smart. Bro science
Why does Derek put MPMD. Isn't there an inverseratio between how many letters you have to put after your name and your level of insecurity?
Lmao, your insecurities are showing trying to put him down and reaching.
He made his channel when he was very young trying to do lifting/dating. Called his channel "More plates, more dates"... MPMD. Get over yourself bud
Lmao you thought it was a designation???
MPMD stands for Morons are Prone to Make Dumb comments
Its his channel bro and brand. Lol stop the hate
WUT
You should not stray too far from TikTok
Master in Broscience...
He needs to stop moving his head can’t take him serious the 🤡
Go away
boring!
this video is for non-cuck looking individuals only sir.
What language are they speaking I thought this was hgh 101