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There is more Melatonin produced and used in peripheral cells during the day than the brain at night. Unlike the melatonin produced in the brain that is linked to the light-dark cycle and influences the circadian master clock , in peripheral tissue It is produced in response to sunlight, especially near infra red and has a neuro-protective, antioxidant and endocrine/paracrine signaling role in cell function especially that of the mitochondria. The brain clock specifically responds to the red light at dawn and sunset and is disrupted by blue light at those times. There is a whole research literature concerning reversal of circadian rhythms in persons working night shifts, submariners and pilots on night flights.

The relaxed style of the chat partnered with the information supported my ability to absorb the information. I’m new to this channel, I am keen to hear more.

Gait and injury. Intriguing. Enjoy 🏋‍♂️🏊🦊🧨

White Kevin Walker Paul Jones Steven

Sttttooop interrupting the speaker!

Enough with the 'OK' interruptions..

Great video! People like the Glucose Goddess should be addressed.

Just found this. Thanks for interviewing Dave! It was great to hear his stories again. I remember him popping in to the clinical ex phys lab when I was a grad student. "Glass, I want to do a stress test" he'd say, and I'd hook him up to an ECG and he'd run his own protocol.

"Experts" are the problem. They're hyperfocused on cholesterol, which shows their bias

Cholesterol isn't a problem if you're metabolically healthy. Stations are garbage

Why does he say cholesterol deposit? It’s more than cholesterol sir!

we love you. Tell us how your calf is holding up.

Dr Glenn. I know you know. I spent some time learning about science: every event alters our likelihood of response. I admire you. You interview people who disagree with you. More than anything, I want to know how your calf holds up when running. I felt such a joy of freedom when I heard you say you would throw your bike into the street. Please tell us how that is going on with you. We love you and need your precious guidance.

Thanks!

Thank you.

It was nice to hear his commonsence opinion of statin drugs and diabetic drugs. He also makes alot of sense talking about exercise. Do what you enjoy and remind ourselves we are not training for the Olympics 😂

How I can support the channel?

Great information!!

Excellent

Nice podcast, do you think you would be able to have Aaron Baggish on the podcast? He's the founder of the cardiovascular performance program in boston Massachusetts General Hospital

@ 1:00:00 . . . The only thing that keeps me from exercising well over 3-6 hrs a day is that my feet hurt. I often hike 8 hours. I just finished a hike that was 10 hours a day for 3 days at high elevation and I'm ready to go out and do it again with a new pair of shoes. I'm 70 years old but have only been doing this for 5 years and never felt better other than the Morton's Neuroma in my left foot that sometimes hurts. I try to keep my HR at or below 145 but I do get it up to 160-170 for short spurts up a steep hill but that's a very low percent of my exercise (1-2%). I try to stick to an 80/20 HR plan but in reality it's more like 90/10 with an occasional race against my own time rather than racing against other people. I doubt I could even run a 10K non-stop trail run but that is on my bucket list.

Great interview, thanks Glenn.

I'm just over half way through and enjoying the interview. I slightly react to one thing and that is the claim that prehistoric man didn't run long distances and that we were not made for that. It is called "persistence hunting" and could reach marathon distances. The evidence of this is pretty undeniable. I'm slightly disappointed that someone whose experise is based on prehistoric man doesn't seem to be aware of this. But that said, all she says makes sense and I agree. I run in barefoot shoes. No big deal.

Thanks!

Incredible episode Dr. Glenn! Super interesting. I was wondering if also lifelong resistance exercisers (or even sports with no aerobic component) have some deleterious effects, like increased arterial stiffness, insulin resistance (due to the high percentage of type 2 muscle fibers), etc... Keep up the great content!!

Not necessarily wrong but Andy has a lot of wires crossed here. Not just forgetting the 20 part of "80/20 z2 training" and the focus on volume and not time-crunched vs "100% z2 training" but the "FTP is Dead" thing he gets worked up over was Sufferfest, not Wahoo.

I believe exercise resistance is the cause of truck drivers being so obese

Excellent insights clearly explained...particularly the paradoxical aspects of calcium burden and exercise , and many other topics.

Very useful👍

👍👍

You need to listen to the people you interview!

I think it's a multi-variable calculus problem that will someday be simulated by computers when the adaptation process is better understood.

Tim Noakes would disagree about the need for carbs for exercise. He has done a 180 degree turn from his earlier view.

I remember watching a presentation by Jeff Galloway. People certainly did get injured during the 70s running boom. That’s why he came up with run walk. But it’s not like run walk was anything new because scout pace was around before that. Scout pace was almost certainly copied from somewhere else. There’s nothing new under the sun as the saying goes.

Very informative. Great guest👍🏼💪🏼😊

Are there potential signs of pre afib in otherwise healthy long distance runners? Bradycardia with escape beats? Chronic mild elevations of AST?

I really appreciate what you are doing with this channel. It is good to hear from those that actually do research.

22:03 I could relate perfectly to this point, switching to a more cushioned shoe from one with little to no cushion. Last Sunday I got a new shoe, and it happened to be my long run day, so I took it out for a spin. Completed it fine, but ended up with a nagging ache in my medial arch of the right foot (which still persists as I am typing 🤣). So, consider this lesson learned for me.

❤

Excellent - will listen to this again (and Episode 69 which is what led me here). 0ne big message was that hearts like vigorous exercise. Dr Levine is not only clear, thoughtful and authoritative but wise enough to caution about specific (rare) circumstances where exercise can be risky. Big thanks for valuable insights, and for letting him talk mostly uninterrupted.

RIP David. 😢😢

We need a summary. Confused the heck out of me. When Insulin is higher and longer than others people then it is diabetes. When the pancreas is not secreting Insulin for glucose presence meaning there is a deficiency of Insulin, it is diabetes. Which one is really diabetes, or is it both conditions?

I have had afib but it wasn't due endurance exercise but rather mitral valve regurgitation which changed the shape of the atria. The changed shape or remodeling is believed to have set off the afib, which was quite severe. Severe means experiencing bpm from 60 to 200 within seconds and back down again. It was way more than uncomfortable but downright hazardous in terms of stroke risk. I have always been an amateur cyclist and that gave me the reserve to survive open heart surgery to fix the mitral valve and afib.

Interesting and helpful information. My least favourite part of listening to researchers is them very casually describing animal studies that cause suffering in these unnatural imposed conditions. Hard to hear.

What is the minimum protein we need when we are not trying to gain more muscle mass? I know we can go all day with zero protein but do we have to eat twice as much to make up for deficient days? How long can we go on say 1/2 of the recommended average minimum. What would happen if I had only 60g of protein a day for 15 days and my lean body mass was around 150 lbs and/or my healthy BMI of 20 was 152 lbs

Good stuff 👏 👍

Thanks.Thanks.🇨🇦

Fascinating. Love the data based approach Dr Levine takes

Great episode with two outstanding scientists with training from the Dave Costill Human Performance Laboratory!

Interesting facts about Jim Fix’s death