#80 - Epigenetics of exercise adaptation and "muscle memory" with Dr Kevin Murach

Dr Glenn McConell chats with Assistant Professor Kevin Murach who is a rising star from the University of Arkansas, USA. Kevin is an expert on muscle, muscle growth, adaptation to exercise training, “muscle memory”, the regulation of muscle growth and muscle memory and the effect of aging etc. Muscle memory definitely seems real (especially in slow muscle fibers). Looks like epigenetics involved more than changes to muscle fibers nuclei. But more work needs to be done, especially in humans. We had a really great chat. I enjoyed it a lot. A very smart chap. Twitter: @KevinMurachPhD
0:00. Introduction and welcome
2:16. How Kevin got into exercise research
6:53. What is “muscle memory”.
9:15. Human evidence of muscle memory
13:58. Mice models to investigate resistance training
19:30. Training, detraining and retraining
20:35. Comparing rodents and human re their different lifespans
22:30. Evidence for muscle memory in mice after ex training
31:05. Mouse model that has both endurance and strength effects
33:25. Voluntary wheel running: matching the training
35:45. 10% greater hypertrophy with retraining
39:25. Mice slow postural muscles didn’t detrain!
44:45. Mechanisms: epigenetics
49:50. Muscle nuclei and exercise training/muscle memory
1:02:00. Muscle memory and epigenetics in the nuclei
1:05:40. MicroRNA and muscle memory
1:07:30. Epigenetics
1:08:35. Exercise training and each bout of exercise
1:11:20. MicroRNA and muscle memory
1:16:20. Balance of protein synthesis and breakdown
1:20:20. Muscle memory: Endurance vs resistance training
1:21:35. Time course of muscle memory
1:23:55. How much training need to get muscle memory
1:25:18. Specificity of ex training muscle memory
1:26:40. Nature and nuture
1:27:25. Dutch famine and epigenetics
1:28:18. Age and muscle memory
1:29:38. Biological sex and muscle memory
1:30:40. Common misconceptions: use it or lose it
1:31:38. Identical twins
1:32:25. Don’t need to go hard or go home.
1:33:05. Research experts vs influencers etc
1:37:15. Takeaway messages
1:39:44. Do health benefits have a memory too?
1:41:45. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (link.springer.com/book/10.100....
Connect with Inside Exercise and Glenn McConell at:
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LinkedIn: Glenn McConell / glenn-mcconell-83475460
ResearchGate: Glenn McConell
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Not medical advice

[@n827]

Great chat! Epigenetics sound like such a promising field to give people control over their bodies that genetics has largely drawn up to fate for so long. Can't wait to learn more about micro RNA and how myogenic regulatory factors influence exercise adaptations

[@insideexercise]

Great point. It’s very important that people understand this re epigenetics and their health etc. Very pleased you enjoyed the chat.

[@olsonderekr]

Really glad you're featuring some early career folks on your podcast. Kevin sounds like a fantastic researcher!

[@jeremyleake6868]

Great interview, thanks for bringing access to these experts and asking them interesting questions.

[@olsonderekr]

I agree 100% with your critique of scientists who shill supplements and aren't experts in their podcast topics. If I am right about who you're referring too, my tin-foil hat theory is that they make recommendations much more complicated than they need to be in order to get people to depend more on their recommendations, thereby increasing their viewership and sponsorship income.

[@robertthompson5501]

AG1 For sale. Thankyou Huberman. Go eat an Avocado or eat at a Saladbar. Love 🙏🏻👹🏊‍♀️🏋🏻

[@robertthompson5501]

Dose strongman training, high calorie, high load, turn on dormant Neanderthal genes? Example Eddie Shaw. How do Performancc Enhancing drugs effect Epigenetic Expression? Speculation and consideration. Interesting topic. Fortunately I did heavy labor in my youth and now enjoy Barbell training as a Senior. Explains why my cohorts at the Ymca are cardio Queens on the elliptical and toy with resistance machines. Stay strong. Thanks 🙏🏻👹🏊‍♀️🏋🏻