I really like how you break down such complicated topics in regards to brain chemistry in a way thats easy to digest. But thankfully you dont make it too watered down, its a perfect mix of "simplified" explanations with a decent amount of more complex explanations which is very insightful. Thanks for the video
Thanks for this video, i really like your insights into ADHD and its causes. Do you perhaps have a citation of the paper regarding high stress and deterioration in synaptic connections? :) I would like to read that continuous stress is not simply “try to relax”, but also destroying the brain or preventing the brain from performing normally. I did see the link to the study in Nature, but I don’t think this is what I was looking for.
Neuroscientist Amy Arnsten at Yale has conducted some of this research, and hers is the first article in the references section, on guanfacine. She summaries and includes references to some of the work on chronic stress.
Is it wholly inherited or, are the environmental circumstances that caused the development of ADHD, physical/emotional development or trauma that is repeated by the adult therefore triggering the same neurological path of development? Even then, continued concussions (domestic violence or sports/accident related) or emotional/psychological trauma are often associated with a history at a younger age.... More likely to be anxious, depressed, stressed, overwhelmed, socially anxious, afraid to reach on a subconscious level, etc. Hmmmmm? 🤔 Causation or correlation?
@@chelseahilbun5678 we know that genes have a strong influence over who gets ADHD, but are not completely deterministic. I have videos on head trauma, and anxiety that are relevant to some of your questions, so for right here I will just point out that looking at the sequence of conditions provides some insight that some of these connections are more than just correlation. For example, ADHD predicts later anxiety, but anxiety early in childhood doesn't predict who is going to develop ADHD.
Can you make a video of what vitamins and minerals are depleted depending on what medication you’re on? Such as if someone is on methamphetamine, that medicine depletes you from XYNZ, therefore you should take supplements for those.
Hey, do you know if alpha 2A receptors are “persistent super sensitizers”?. There are some studies showing that even after stopping Guanfacine it took 6 months to relapse on symptoms. A personal annecdote from me is that I’ve also experienced this, and I’m still different after taking it and discontinuing it. Would this suggest that maybe chronic under stimulation of alpha 2A due to stress and anxiety causes an internal desensitization to alpha 2A causing it to simply not be as active and visa Versa?
That sounds like a possibility. Clinically, I've seen some people feel they lost benefit from guanfacine shortly after stopping it, and others whose experience matches yours more closely.
@@DrJohnKruse it seems like it’s time dependent aswell, because when I stopped it early on I would get heavy brain fog and revert. But reguardless even when I was off it it didn’t sensitize it to an equivalent of 1mg. So it definitely takes some time.
I feel like , since I got out of a narcissistic abusive relationship 3 years ago .. I have lost my spark .. I got put on dex finally last May but I still struggle more so now with being reclusive , avoidant , and personal hygiene .. I feel like my IQ has dropped and I hate to say it but it was after having two shots of the Pfizer vaccine too .. I hyperixate on my meds and end up focussing on one task for too long .. I’m really stuck .. And my child needs me to be OK 😢
I hope that you are sharing all of these issues with whoever is prescribing the dex. Some of the symptoms you describe are classic for depression. Often a combination of talking therapy and medications helps in such situations.
The human body is so flawed. Alpha 2A, One of the modulators for neurotransmitter over excitement, is “deactivated” by anxiety… it’s like a self reinforcing cycle, anxiety creates more anxiety.
Maybe it is more that the world/environments that we have created are what is flawed, and too different from what our brains and bodies evolved to respond to.
@ you’re right. This isn’t the way we should be living. Maybe this is part of the reason why suicide rate is so high, and maybe in the future people will be adapted to have brains that can handle this better.
@@DrJohnKruse hey, there was one more thing I wanted to mention. Have you read the studies reguarding prescription of Wellbutrin for bipolar and the risk of mania? Apparently the longer people are on it for bipolar the risk/chance increased. Considering it’s a NRI and what you discussed in this video it’s interesting. Is it possible that the increased norepinephrine and dopamine from Wellbutrin deactivates alpha 2 receptors and then overtime leads to a higher risk of mania?
Good question. I think that the most important part of the answer is that this is not a simple linear relationship, it isn't that more NE always has a detrimental effects on connectivity in the prefrontal cortex. It is only when the NE is above some critical threshold that it is problematic. Secondly, the alpha-2 NE receptors on neurons receiving glutamate input seem to be the important place where excessive NE can push the system into a problematic zone. If the NE transporter's distribution isn't directly paired with these alpha-2 receptors, then you might be primarily boosting NE in areas that are having less impact than you think on the glutamate cells. But yes, theoretically chronic stress pushes the frontal cortex in a more ADHD-like direction. Whether we should be calling this ADHD or PTSD, in my mind is an open question and I believe we will need to change how we conceptualize and label many of our mental health condition.
Thank you for the explanation. I'll have to read up on the Alpha 2 receptor to properly understand. Would an a2 receptor agonist risk reducing connectivity (Guanfacine)? That would be surprising to me given tge outcomes in ADHD. Maybe it has sometgingbto do with post synaptic agonism?
@@smis7904 guanfacine is an alpha-2 agonist approved for treating ADHD, and its actions on post-synaptic neurons that are receiving glutamate input improves synaptic connectivity in the prefrontal cortex. The reference on guanfacine in the description of this video provides extensive detail on this.
Is it wholly inherited or, are the environmental circumstances that caused the development of ADHD, physical/emotional development or trauma that is repeated by the adult therefore triggering the same neurological path of development? Even then, continued concussions (domestic violence or sports/accident related) or emotional/psychological trauma are often associated with a history at a younger age.... More likely to be anxious, depressed, stressed, overwhelmed, socially anxious, afraid to reach on a subconscious level, etc. Hmmmmm? 🤔 Causation or correlation? I have had over a dozen concussions, and was diagnosed with ADHD 2 years ago- 32 years old. Repeat concussions and (C&)PTSD. I know how i needed to act to avoid "trouble" as a teen. It makes fu*king sense.
I agree with your conclusions.... I've never thought ADHD was accurate in the sense that I'd have always had it...I can honestly recall stages of my life where it had ebbs and flows that all correlated to my environmental situation.
I really like how you break down such complicated topics in regards to brain chemistry in a way thats easy to digest. But thankfully you dont make it too watered down, its a perfect mix of "simplified" explanations with a decent amount of more complex explanations which is very insightful. Thanks for the video
I'm glad that you and others are finding my videos helpful.
I LOVED this! Took me back to my neuroscience classes in university ☺️
This is fascinating! Many thanks, and I subscribed .
Also, I just saw your dog, and she's ADORABLE ❤
Great! That's Mr. Cupcake (We added the Mr. to his name because most people think that he's a she.)
@DrJohnKruse Mr. Cupcake is darling.
Thanks for this video, i really like your insights into ADHD and its causes. Do you perhaps have a citation of the paper regarding high stress and deterioration in synaptic connections? :) I would like to read that continuous stress is not simply “try to relax”, but also destroying the brain or preventing the brain from performing normally. I did see the link to the study in Nature, but I don’t think this is what I was looking for.
Neuroscientist Amy Arnsten at Yale has conducted some of this research, and hers is the first article in the references section, on guanfacine. She summaries and includes references to some of the work on chronic stress.
@@DrJohnKruse thanks! Ill read it and be at the q&a tomorrow. Have a great day!
Thank you!
It's important to notes that ADHD is usually inherited from parents, not acquired through brain injury.
Yes, I did not make that clear.
Is it wholly inherited or, are the environmental circumstances that caused the development of ADHD, physical/emotional development or trauma that is repeated by the adult therefore triggering the same neurological path of development? Even then, continued concussions (domestic violence or sports/accident related) or emotional/psychological trauma are often associated with a history at a younger age.... More likely to be anxious, depressed, stressed, overwhelmed, socially anxious, afraid to reach on a subconscious level, etc.
Hmmmmm? 🤔
Causation or correlation?
@@chelseahilbun5678 we know that genes have a strong influence over who gets ADHD, but are not completely deterministic. I have videos on head trauma, and anxiety that are relevant to some of your questions, so for right here I will just point out that looking at the sequence of conditions provides some insight that some of these connections are more than just correlation. For example, ADHD predicts later anxiety, but anxiety early in childhood doesn't predict who is going to develop ADHD.
Can you make a video of what vitamins and minerals are depleted depending on what medication you’re on? Such as if someone is on methamphetamine, that medicine depletes you from XYNZ, therefore you should take supplements for those.
If I find enough research on this, I will make it into a video. Thanks for the idea.
Hey, do you know if alpha 2A receptors are “persistent super sensitizers”?. There are some studies showing that even after stopping Guanfacine it took 6 months to relapse on symptoms. A personal annecdote from me is that I’ve also experienced this, and I’m still different after taking it and discontinuing it. Would this suggest that maybe chronic under stimulation of alpha 2A due to stress and anxiety causes an internal desensitization to alpha 2A causing it to simply not be as active and visa Versa?
That sounds like a possibility. Clinically, I've seen some people feel they lost benefit from guanfacine shortly after stopping it, and others whose experience matches yours more closely.
@@DrJohnKruse it seems like it’s time dependent aswell, because when I stopped it early on I would get heavy brain fog and revert. But reguardless even when I was off it it didn’t sensitize it to an equivalent of 1mg. So it definitely takes some time.
I feel like , since I got out of a narcissistic abusive relationship 3 years ago ..
I have lost my spark ..
I got put on dex finally last May but I still struggle more so now with being reclusive , avoidant , and personal hygiene .. I feel like my IQ has dropped and I hate to say it but it was after having two shots of the Pfizer vaccine too ..
I hyperixate on my meds and end up focussing on one task for too long ..
I’m really stuck .. And my child needs me to be OK 😢
I hope that you are sharing all of these issues with whoever is prescribing the dex. Some of the symptoms you describe are classic for depression. Often a combination of talking therapy and medications helps in such situations.
Really wish you were my doctor 😅
The human body is so flawed. Alpha 2A, One of the modulators for neurotransmitter over excitement, is “deactivated” by anxiety… it’s like a self reinforcing cycle, anxiety creates more anxiety.
Maybe it is more that the world/environments that we have created are what is flawed, and too different from what our brains and bodies evolved to respond to.
@ you’re right. This isn’t the way we should be living. Maybe this is part of the reason why suicide rate is so high, and maybe in the future people will be adapted to have brains that can handle this better.
It's not flawed at all ... the environment and consumption has been toxic. Let's get this right.
@@plymix8389 hopefully we will not just learn to adapt but we will also make this a better world.
@@DrJohnKruse hey, there was one more thing I wanted to mention. Have you read the studies reguarding prescription of Wellbutrin for bipolar and the risk of mania? Apparently the longer people are on it for bipolar the risk/chance increased. Considering it’s a NRI and what you discussed in this video it’s interesting. Is it possible that the increased norepinephrine and dopamine from Wellbutrin deactivates alpha 2 receptors and then overtime leads to a higher risk of mania?
If stress raises NE and this reduces connectivity, would an NRI make the PFC more prone to ADHD over time?
Good question. I think that the most important part of the answer is that this is not a simple linear relationship, it isn't that more NE always has a detrimental effects on connectivity in the prefrontal cortex. It is only when the NE is above some critical threshold that it is problematic. Secondly, the alpha-2 NE receptors on neurons receiving glutamate input seem to be the important place where excessive NE can push the system into a problematic zone. If the NE transporter's distribution isn't directly paired with these alpha-2 receptors, then you might be primarily boosting NE in areas that are having less impact than you think on the glutamate cells.
But yes, theoretically chronic stress pushes the frontal cortex in a more ADHD-like direction. Whether we should be calling this ADHD or PTSD, in my mind is an open question and I believe we will need to change how we conceptualize and label many of our mental health condition.
Thank you for the explanation. I'll have to read up on the Alpha 2 receptor to properly understand. Would an a2 receptor agonist risk reducing connectivity (Guanfacine)? That would be surprising to me given tge outcomes in ADHD. Maybe it has sometgingbto do with post synaptic agonism?
@@smis7904 guanfacine is an alpha-2 agonist approved for treating ADHD, and its actions on post-synaptic neurons that are receiving glutamate input improves synaptic connectivity in the prefrontal cortex. The reference on guanfacine in the description of this video provides extensive detail on this.
Thank you I missed that
Is it wholly inherited or, are the environmental circumstances that caused the development of ADHD, physical/emotional development or trauma that is repeated by the adult therefore triggering the same neurological path of development? Even then, continued concussions (domestic violence or sports/accident related) or emotional/psychological trauma are often associated with a history at a younger age.... More likely to be anxious, depressed, stressed, overwhelmed, socially anxious, afraid to reach on a subconscious level, etc.
Hmmmmm? 🤔
Causation or correlation?
I have had over a dozen concussions, and was diagnosed with ADHD 2 years ago- 32 years old. Repeat concussions and (C&)PTSD. I know how i needed to act to avoid "trouble" as a teen. It makes fu*king sense.
I agree with your conclusions.... I've never thought ADHD was accurate in the sense that I'd have always had it...I can honestly recall stages of my life where it had ebbs and flows that all correlated to my environmental situation.