Histones
ฝัง
- เผยแพร่เมื่อ 8 ก.ย. 2024
- Histones- This lecture explains about the histone protein structure and also about the histone acetylation and histone methylation in details. Histones are tremendously alkaline proteins located in eukaryotic cell nuclei that bundle and order the DNA into structural models called nucleosomes. They are the executive protein accessories of chromatin, appearing as spools round which DNA winds, and play a role in gene legislation. With out histones, the unwound DNA in chromosomes can be very lengthy (a length to width ratio of more than 10 million to 1 in human DNA). For instance, each and every human phone has about 1.8 meters of DNA, (~6 feet) but wound on the histones it has about 90 micrometers (0.09 mm) of chromatin, which, when duplicated and condensed for the period of mitosis, influence in about one hundred twenty micrometers of chromosomes.
Five essential families of histones exist: H1/H5, H2A, H2B, H3 and H4. Histones H2A, H2B, H3 and H4 are referred to as the core histones, at the same time histones H1 and H5 are referred to as the linker histones.
Two of each of the core histones collect to type one octameric nucleosome core, roughly 63 Angstroms in diameter (a solenoid (DNA)-like particle). 147 base pairs of DNA wrap round this core particle 1.Sixty five occasions in a left-exceeded super-helical turn to offer a particle of round one hundred Angstroms across.The linker histone H1 binds the nucleosome on the entry and exit sites of the DNA, therefore locking the DNA into location and permitting the formation of higher order structure. The most normal such formation is the ten nm fiber or beads on a string conformation. This includes the wrapping of DNA round nucleosomes with roughly 50 base pairs of DNA separating each and every pair of nucleosomes (also referred to as linker DNA). Greater-order buildings incorporate the 30 nm fiber (forming an irregular zigzag) and one hundred nm fiber, these being the buildings located in typical cells. For the duration of mitosis and meiosis, the condensed chromosomes are assembled through interactions between nucleosomes and other regulatory proteins.
For more information, log on to-
www.shomusbiolo...
Get Shomu's Biology DVD set here-
www.shomusbiolo...
Download the study materials here-
shomusbiology.c...
Remember Shomu’s Biology is created to spread the knowledge of life science and biology by sharing all this free biology lectures video and animation presented by Suman Bhattacharjee in TH-cam. All these tutorials are brought to you for free. Please subscribe to our channel so that we can grow together. You can check for any of the following services from Shomu’s Biology-
Buy Shomu’s Biology lecture DVD set- www.shomusbiology.com/dvd-store
Shomu’s Biology assignment services - www.shomusbiology.com/assignment -help
Join Online coaching for CSIR NET exam - www.shomusbiology.com/net-coaching
We are social. Find us on different sites here-
Our Website - www.shomusbiology.com
Facebook page- / shomusbiology
Twitter - / shomusbiology
SlideShare- www.slideshare.net/shomusbiology
Google plus- plus.google.co...
LinkedIn - / suman-bhattacharjee-2a...
TH-cam- / thefunsuman
Thank you for watching
![[Watch Party] RoV Pro League 2024 Winter | ( Bacon Time Vs PSG )](http://i.ytimg.com/vi/zM25REvnJW4/mqdefault.jpg)
the way you explain, makes all nonsense stuff and complicated study into simple and understandable education, is really amazing the way you teach us.
thank you so much
i had followed your clips since my GCSE
I am a class nine student and was in a trouble to realize it but now I have gotten full concept. Thanks a lot.
You're welcome
Every time I'm going through my medical genetics lectures I have your page open on a tab. This is so helpful, thank you so much!!
this is a great explanation! I just spent 2 hours trying to read a chapter of a textbook on this but you cleared it up in 13 minutes :)
Thank you so much for appreciating my efforts
Amazing capacity you have to handle the classes. I am 63 yrs, but still enjoying your class. Best wishes
I am glad to hear that you're getting benefit from my lectures
TQ TQ TQ TQ sooo much for all ur vedioes we are blessed to c u in TH-cam brother becouse from last 3 semister iam following ur vedioes only very detailed information I hard from u I dint written in nodes also directly i attempted I am getting 80% from last 3 sems TQ bro
Thank you so much for appreciating my efforts
Omg..it is an amazing lecture...I was so confused for the concept of histones but now I am cleared very well....keep it up sir👍👍
You're welcome. Glad to hear that you're getting benefit from my lectures
The way you explain the difficult topics is amazing.. I admire your way of teaching.. Simply awesome
What you say at 5 minutes 50 seconds is not true.
H2B-H2A dimer and H3-H4 dimer do not first combine to form a tetramer.
Instead, two H3-H4 dimers combine to form a tetramer, and then two H2A-H2B dimers combine with the tetramer to form the octamer that will be wrapped in DNA to form a nucleosome.
Hydra572HQ exactly you re right dude
Thanks a lot
@Porter Kyng nobody gives a damn bro
everytime I'm lost and confused this guy saves me okay. THANK YOU VERY MUCH!!!!!!!!!!1 YOUR VIDEOS ARE SIMPLY SO HELPFUL THANK YOU VERY MUCH
For months I auto-skipped all of this guy's videos due to the accent. Then I watched one out of desperation, and it's extremely good wtf. I missed out.
Thank you so much for appreciating my efforts
Very helpful video Thank you
You're welcome. Glad to hear that you're getting benefit from my lectures
Amazing how you make these sometimes complex mechanism relatable and fun...good job!
+temple2infinity thank you. Glad you liked my lectures
Thanks... Amazing, simple, brief, clear and well explained
You're welcome. Glad to hear that you're getting benefit from my lectures
THANK YOU ! YOU'RE THE DISCOVERY OF THE DAY IG ! 13 min felt like 2 min ❣️
Good job Shomu! You have incredible passion for teaching.
sir ur teaching skills r amazing. thank u for such kind of videos. 1000 likes for u sir🙂
This was a great explanation! Thank you!😊
You're welcome
Hello ! It's not two tetramere of histones that make an octamere. It's one tetramere of H3-H4 + two dimere of H2A-H2B. I am not sure you said that in your video.
Sorry if I made grammar mistakes I am not an english speaker.
Really?
Very informative
You're welcome
really awesome kind of job u r doing ...otherwise students like us would have been in a huge problem. thanks for providing such a good lecture
Glad to hear that you are getting benefit from the videos
This man has a video on every topic I search for and I like it✨✨
Thank you so much for appreciating my efforts
Pls teach us biology for NEET as well
But in detail like this 🙏🏼
Amazing teacher
Thank you so much for appreciating my efforts
Thank you a lot ! You make this topic much more accessible for students !
Thank you so much for your share ! The interpretation is easy to understand.
I m preparing for csir net Dec 2018 by watching yr vdos.. hopefully I'll let u knw about my positive result...
Thank you. Glad you liked my lectures
your knowledge and specially method of teaching is really amazing ...
+Sana Rani thank you. Glad you liked my lectures
0.6 mm is too long for the condense form to package inside the nucleus .
But your way of information titling is wonderful .
Thank you sir
Your classes are very helpful🙌
You're welcome
amazing.....
You're welcome
Sir it's absolutely amazing..! The way u Explain everything is just incredible
Thank you so much for appreciating my efforts
WOW...Awesome Teaching Man...
Your teaching skill is amazing!!!.God bless you :)
Thank you. Glad you liked my lectures
incredible teacher
The cell size is 10 to 100μm in diameter and the .6mm makes 600μm, kindly clarify. Thanks. By the way your way of explaining is amazing.
Your videos are awesome to understand and easy....
Thank you. Glad you liked my lectures
Shomu bhaiya tnk u ...
You're welcome
Well Explained
Thank you
Its a really soo helpful ...Bundles of thanks for providing us such an excellent site
Thank you .it's really good n easy to understand.
You're welcome
Please make some video on non histone proteins as well (like the HMG proteins). Thank you, this video was awesome!!
Very nice n simple way to explain. Keep up the gud work
Thank you. Glad you liked my lectures
Can't believe this video is 6 year old, and i am watching it now.. people are taking advantage form six years
You're welcome
Thank you very much.... is there a video that explains the DNA in the mitochondria which do not have histones and how they become compacted as in the nucleus?
becose mit dna circle form
Nice explanation sir, thanks a lot... really I'm very grateful to you
Thank you. Glad you liked my lectures
Simple and direct into the point... amazing❤❤
Thank you for appreciating my efforts
my final exam is tomorrow I hope that I get the highest score and you explained this very well:)
Thank you so much for appreciating my efforts
Thank you
You're welcome
Thank you so much
You're welcome
thank you for sharing the knowledge
You're welcome
Bhaiya what is this N tail... Could please explain me i am in class 10 that's why I am not getting it
Thank you so much bhai😭
You're welcome
Hello sir! I think the best way to describe the way the histones and the DNA strand are arranged is called "beads on a string"
Hope this helps! 😊
Yes
tnx sir literally ur way of teaching is amazing
2 questions....
why some receptors are stable at cell membrane & why other are at cytoplasm ?
what is novel mechanism of stability of protein?
My Knowledge is kind of Naive but it has something with Hydrophobic and Hydrophilicity of Proteins associated with the Receptors.
Tq sir for your efforts
You're welcome
Thanks sir
very interesting, induce me to learn more thank you
Thank you so much for this lecture!🤗♥️
You're welcome
Really helpful
You have great energy. You make learning fun!
Thank you. Glad you liked my lectures
Hi. Can ı ask your something? where is the Histon1?Video is sucsessful.
great video sir.plz make some video on colligative properties
+Poonam Dixit surely do
Thank's dr💙💙💙
You're welcome
thank you too
You're welcome
Thnq for the knowledge u share..
You're welcome
Thankyou sir❤
You're welcome
No sir, I think h3,h4 formed a tetramer, then it bound to the DNA, recruits two copies of h2a h2b dimer and completes the octamer in this way. but u said that the (h3 h34 h2a h2b formed a tetramer)*2.
I said that all these 4 subunits formed octamer presenting 2 times each. I didn't cment on the sequence of their arrangement
@@shomusbiologyofficialBiology ok sir, got it.
Thanku so much sir
You're welcome. Glad to hear that you're getting benefit from my lectures
You are so F so smart!
Excellent!!!!!!!!
thanks for this explicit and concise video
sir, what is the function of Histone (H1) beside linking?? (if any)
so helpful. thank you
You're welcome
sir euchromatin lecture is very good thank you
Sir what about the H1 histone protein?It does not form a part of the nucleosome but it forms a part of the histone family.
Gd teaching sir
Thank you. Glad you liked my lectures
wonderfully explained. thanku
Thnku sir for this lesson ☺️
You're welcome
Thanks, mate. fantastic explanation.
you are doing a great job at such a young age, kudos. I am your student if you accept.
Just becouse of you i complet my msc without attending classes... Thank you so much...
+Vishal Joshi glad you liked my lectures
Don't tell huge lie like it.
sir plz tell me where is methylation or acetylation occur at c or N terminal
Please help: Are the nucleosomes at regular distance from each other? If not what is the reason?
Perfect sir ❤️💯💯
Thank you
good thank you
Thank you so much!
Thank u sir
You're welcome. Glad to hear that you're getting benefit from my lectures
Excellent information, l but
there is a need of explanation speed should be slow, it is to much fast.
Ur great
The thing you teach is nice but the way (expressions you make) is very funny.
Hmm
May god bless you Sir 🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏🙏
You're welcome
Best 👍
Thank you
Somu bhai ke jai ho
Thank you
what are non histones and its functions?
very nice shomu sir great explanation👍
Here u mentioned that H2A and H2B are exist near entry and exit site while in your histone and nucleosome video from chapter 7 , you explained that H3 and H4 are near entry and exit site.🙄
I want an explanation on DNA packaging in prokaryotes and eukaryotes..
Sir, what is the ratio of protein and DNA amount in chromatin?
Please do a video on dna packaging sir...