I just wish I had a longer lifetime (I just turned 80) because I am always discovering new things I would like to know something about, and the above subject is another! I had never heard of what she is talking about. So I was glad to find out there's a book that will try to enlighten what the lecturer was talking about.
I'm here after reading her book "The Epigenetics Revolution" to learn about possible updates in the field since it came out a few years ago. I would highly suggest the book to anyone as I had no background knowledge other than high school Biology and yet every chapter would blow me away.
I absolutely have to watch this again and again. She has few equals in terms of clarity and lucidity. I am going to forward this to my entire family. One of the most interesting topics explained by one of the best presenters.
The most boring presentation. Boring verbal diarrhea and the poor woman is totally confused as to the meaning of Epigenetic. What saves her is the cute accent. She is trully the product of Rockefeller education system. Sad.
@@gracegwozdz8185. Well that’s a rather pretentious comment, given that she is an expert in epigenetics. Perhaps you would care to enlighten us with your wisdom on where she went wrong?
I'm currently reading 'Junk DNA' and I can assure you that it is really informative and it doesn't bore you. As a first-year medical college student, it is really helpful to visualize the epigenetic differentiation. Examples she gives are hilarious.
I scored rotten childhood, alcoholism, diabetes, 40yrs depression. My parents died 2012. I went outside and stood in the sun. Instant relief then happiness. Counselling and diagnosed as having aspergers (3yrs old emotionally top 2% computational brain). I took up Zentangling Art and I am still changing & growing. It took 20 yrs after MtDna test for me to find a living relative and I discovered that 5 gens back my ancestor came from Sweden who was a Sami. I then discovered I had inherited characteristics from that cultures but not in the same configuration. I bought a good copy of the I Ching and asked HOW I could bring information from the MtDna into my conciousness. The answer was hexagram 19. It told me not to think about it or ask another question and when I asked another question I was told to not do that again. This is simplified. The overall answer was that the answer was approaching. Sooooo... I bought a book on epigenetics, wrote to a scientist and I find your teaching style that puts the text books I am reading into context. I am 72 and am like a teenager. THANK you so much.
The 8 proteins are histones and form a protein complex known as a histone octamer, which is spool shaped (marshmallows were used in the demonstration). The 8 proteins in the histone octamer are actually 2 copies of 4 proteins, H2A, H2B, H3 and H4. DNA wraps around the histone octamer known as a nucleosome and they form chains like beads on a string making up chromatin. A nucleosome can be defined as a small length of DNA wrapped around eight histone proteins. The key difference between chromatin and nucleosome is that chromatin is a whole structure of complex DNA and proteins while nucleosome is a basic unit of chromatin. The beads on a string make up something called euchromatin or open chromatin that is enriched in genes and active under transcription (transfer of genetic instructions) which is why it is so important in epigenetics and changes in the phenotype (physical traits- e.g. appearance).
Yes - but we need the right stimulus; and that can come only from the WORD of GOD, found in the Bible. We could easily deteriorate into barbarism, especially if we start copying animals, instead of reminding ourselves that we are made in the image of GOD.
How fortunate that I in india can access this extraordinary lecture delivered so well and generously sprinkled with humor. Great contribution to science education. Have her books which are so precious for me
Reading her book now after watching this a few months ago! Brilliant and exciting literature! Epigenetics is such a fascinating field! This is telling us how we can affect our future progeny!
Its all actually very simple to understand when you grasp what is actually occurring in terms of epigentics and how we are products of evolution - genetics and events - what we do and what is done to us
If for whatever reason molecular biology doesn't work out for Nessa Carey, she can surely do well as a stand-up comedian! Very entertaining and enlightening talk!
First time i am watching her. Today I purchased her book " The Epigenetics Revolution. Not my subject. But i have interest. Happy to watch. Thank you Madam. Regards
Great video! Increasingly our behavior determines our longevity. Just as weight scales provide transparency and motivate dieting, epigenetic tests now make biological age (as distinct from chronological age) more transparent and motivate us to adopt right behaviors to help us live longer.
Her explanation about stress and childhood experiences is interesting. I was very fortunate because I had a pretty stable, happy childhood with a protective father who thought I was a piece of gold and a loving mother who was a great nurturer. Even though I was overweight and constantly bullied, I retained my happiness and confidence that has allowed me to be successful in my career and personal life. I am married to a great person, but have noticed that he is usually depressed and insecure. His sister has finally admitted that out of 6 siblings, he was given the least amount of attention and praise and was often criticized. This was needed information for me as his spouse because I can now understand why he rather that I remain overweight. When I lost most of my weight, my husband would exhibit jealousy and insecurity. He would retreat into his den, and not talk to me. Now that I have lost my mobility, my husband seems happy which I find hurtful, but with theory, I have learned that he feels empowered because he feels no one will find me attractive and he can now be the only person I can depend
What a wonderful (and delicious!) lecture! I am enraptured by her humour and her passion. What a shame I am watching this 9 years after the release of the original video.
Nice. But molecular genetics was already about gene expression regulation, in bacteria, at the start. Sex is a molecular dialog and it has probably many and variate levels of (self) interpretation. I have discovered computer science in the working of the DNA of Escherichia Coli, a long time ago (Jacob & Monod mainly).
Fascinating subject, i'd never heard of this subject before. Props to the lecturer for giving such an entertaining lecture on a complicated subject! I hope you have her back again.
I wonder how many people who watched this wished their jobs required them to play with candy in order to do it effectively? I think a lot of companies wouldn't be so stuffy if they allowed their workers to play with candy sometimes...
Finally! we have an exciting, summation of information about this field! Thank you for posting. Best explanations, clear analogies and diagrams I've ever found .I've been interested in this field for many years, though no longer a formal student. This great video brings me up to date.
All I want to do right now is eat strawberry laces and jelly tots.....on a serious note, this lecture was FASCINATING - thank you Nessa for your fabulous energy teaching this
Oh no! Your exposure to the video (environmental factor) has changed your mental content, which could change your behaviour which could change your epigenetics, which could change the future of your offspring? Good grief this rabbit hole goes deep...
The DNA code starts from the same then the coding changes but the DNA coding is all the same in the start of the code. Example is like computer coding. Code DNAMOMDAD then add on EYESLASHES or DNADADMOM Liver etc etc. It's so damn AMAZING
There's one thing I am confused about. So if the histones are wrapped around our genes, and say you become a smoker (but no one in your family tree extending hundreds of years smoked) and the chemical tag is added to the histones to make that gene become 'expressed', does that mean that the 'smoker gene' is predetermined? In other words, will I have a 'smoking gene' by default that is turned off, but will only be turned on if I smoke?
Would a babies/child’s dna receptors be affected/changed by a traumatic birth experience? Ie would a more ‘relaxed’, non stressfull/traumatic birth experience have a better outcome for a child later in Life?
I would love to know the other side of the experiment, where mice with caring mothers were put with not so caring mothers and then had a traumatized life. What happens when a mice with a not so caring mother is put with a caring mother? They get better? They get "normal"? They don't get better? I don't know where to ask this question :( If someone could give me a clue, i would be very grateful.
🪄✨ Made with SummarizeYT 0:49 - The human genome sequence was first released in 2001, causing a huge hoopla. 2:03 - Epigenetic phenomena have been known for a long time but were not given much attention. 3:00 - Laboratory mice with the same genetic background can have different weights due to epigenetic factors. 5:01 - Gender in crocodiles is determined by the temperature at which the eggs develop, not genetics. 6:01 - Different cell types in our body have the same DNA code but exhibit different characteristics. 8:08 - Epigenetics plays a crucial role in gene expression and can be influenced by external factors. 12:00 - Epigenetic modifications can switch genes on and off, leading to different gene expressions. 14:00 - Epigenetic modifications can be compared to different flavors of jelly tots, introducing flexibility in gene expression. 16:15 - Epigenetic modifications can also compact DNA, permanently switching off gene expression. 17:27 - Epigenetic modifications can go wrong and contribute to diseases like cancer and diabetes. 19:01 - Children who have experienced abuse or trauma in their childhood are more likely to develop chronic diseases later in life. 20:07 - Epigenetics can influence what happens in organisms without altering the DNA sequence. 20:42 - Baby rats that are loved and cared for by their mothers have low levels of stress hormones. 22:03 - Epigenetic modifications in rats can be passed down from generation to generation. 24:01 - Epigenetic information is necessary for mammalian reproduction. 26:41 - Epigenetic changes can result in significant differences in physical characteristics, as seen in agouti mice. 30:03 - Mice can learn to associate a smell with something negative, and this fear response can be passed on to their offspring. 31:43 - Lamarck's theory of acquired characteristics is not entirely accurate, but epigenetic changes can be influenced by the environment. 34:01 - Trauma experienced by male mice can be passed on to their offspring. 35:05 - Epigenetic changes can affect the offspring's physical characteristics, as seen in the experiment with female mice. 36:03 - Identical twins can have different outcomes due to epigenetic changes.
so the dna is still the same, just the little "jelly" dots that attach to the dna that a person might develop while interacting with his environment? But what's the mechanism behind the epigenetic changes (my guess it's still the DNA that gives instructions to the protein to make the epigenetic changes)...I mean could epigenetic changes lead to the eventual creation of a new species? Thinking more ahead, how much can we augment our body through tweaking the expression of various genes, like would we be able to grow a new arm through epigenetics, or is that sort of mutation still dependent on the manipulation of DNA? You say that the little "jelly" dots, sorry I forget the exact term you used for those molecules, attach to the genes and affect their individual expression, but how many genes do we have, what are each gene's functionalities, how does each gene interact with each other, and what explains the difference between us and a chimp or a bird or something? God damn it get more research done lady! My back is hurting from watching all these Royal Institute videos laying on my bed at 1AM in California, and I also don't have a car to go to work tomorrow morning, and I think it'd be really nice if DNA technology can allow me to grow a pair of wings! (though the image might be a bit grotesque) so I can fly around to work and buy groceries or something...
This is EPIC!! Lamarck is partly vindicated, but that's the least of it. We are more "adjustable" than we realized before, and some of these adjustments can be passed on to the next generation. LOTS to think about, even for the ordinary person in the street who wants their offspring to be healthy and talented.
In all biology textbooks, Galapagos finches are mentioned as a prime example of evolution. However, a relatively recent study conducted by Peter and Rose-Marie Grant documents that the changes in beak size and shape of these birds that Darwin observed do not take millions of years, but change continuously at a rapid rate of as little as two years and that the changes are reversible. It is very likely that it is epigenetic adaptation, not evolution in the Darwinian sense. This certainly also applies in many other cases where adaptation is interpreted as macroevolution today. The theory of evolution must and will be rewritten.
Wow, really enjoyed this lecture. Any sociological/psychological applications or assumptions linked to these findings? ie, poverty, oppression, consistent trauma etc...
Great video! I can imagine that practical living advice can come from epigenetics, like how i can change my own in a positive way. Any chance to get that?
Hmm, for example if you don't smoke, your epigenetics for requesting more nicotin don't get switched on and your kids probably won't smoke either. Does this answer your question?
Fantastic, Love the energy your brought to your book The Epigenetics Revolution" I wonder if you can see the link between Epigenetics and Buddhist Karma. (They are both very deep matters) Any Buddhist's out there pls read this and think....
Unfortunately she was not able to explain how homeostasis knows which genes to turn on and off. Or how a certain chemical affects certain genes and not others. Are certain aspects of evolution Lemarkian? Evolution takes place because of needs and choices? Do epigenetic changes eventually lead to sequence changes?
Excellent. I am not much of an animal lover but I began to feel more and more uncomfortable at the descriptions of the animal experiments. Also when she describes epigenetic modifications I thought she committed the "Time Machine" error in that she described it rather than explained. Nevertheless a superb piece of education for me by a brilliant teacher!
How would you explain a Monarch Butterfly’s migration from central Mexico to Canada and back to the same tree? There are four generations in a year. The migration is a year long. The returning butterfly is the great grandchild of the one that left the overwintering tree. How is the information passed on through the generations?
@@hayuseen6683 No, crocodiles and dinosaurs share a common ancestor but they don't "descend" from one another (That honour corresponds to birds, aka avian dinosaurs). If you want to put in geographical terms, they're like Serbia and Slovenia sharing an extinct Yugoslavia
4 ปีที่แล้ว
While it is true that she made a mistake, this is not a smart argument. Plenty of species of fsh descend from Coelicanth but it's still here
Thank you for great presentation! Ive been thinking about one question. In the "bullied" mouse experiment epigenetics were not transmitted but in cherry blossom smell, the fear was transmitted to offspting due to epigenetics. Is that a contradiction that in some cases environmental quality gets passed in others not?
Very nice video and a good, yet brief presentation. I wonder what sense is actually used in the female to identify that the male was traumatized and causes the offspring to be runts. Of course I do not expect some active cognitive process of the female. But I would run the experiment over and over again with a blind, then a deaf, then an asomnic (is that word even correct?), etc. female mice, also combinations of these senses. Being unscientific now, I imagine that smell could be the important sense here, but that is pure speculation and this approach (guessing) is not scientific at all. This talk made me think. I was born premature and would not survive without modern medicine (in the 1980s). My parents told me how hard it was for them to see this tiny helpless being enclosed in an incubator, they could not hold it in their arms, cuddle with it. Now I hear in this video that mice who were less loved tend to be more depressed. So naturally I wonder if there is any connection to myself now, as in my very first days of life I was inside an artificial environment, connected to hoses (my lungs were not fully developed at that time). I tended to be "cloudy" more than my brother and peers during childhood and even now many people tell me that I am a pessimist and sometimes that I am depressed (and frankly I feel that too, but do not recognize it as a serious problem yet). This thoughts could well be just confirmation bias of a speculation. Nevertheless, it makes me think broader now. Conclusions? None. I am not an expert in this at all and actually cannot do anything about it, so why bother about some hastened amateur conclusion? It does not make life easier. But as we say in my native language, the bug is successfully planted in my head. Meaning that this idea (or meme if you want) which came out of pure speculation is in my memory and I will have to live with it from now on. I can just hope to forget it, or at least not be reminded too often about that. I hate my brain, it makes me remember unpleasant and/or embarrassing memories all the time.
I too wondered the same about the mice, would love a link to that experiment and more. I think depression has more to do with early childhood and less to do with the infant years......my sister is prone to depression and a few of my friends, and after years of observing and analyzing them and why and when they get depressed it usually has to a lot to do with being or feeling inadequate or unaccomplished in life.....my sister grew up with higher expectations from my parents than I did and I see that with my friends as well....in turn I don't let failures get me down probably because my folks were more relaxed about my shortcomings and so I take life in strides and it us what it is. When I talked with my sister about this at first she denied it, but over the years she has finally accepted this and started changing her own expectations for herself and worked on not caring how others view her or her accomplishments....what a difference it has made in her getting depressed....she is more happy and enjoying life. Hope that helps you with your depressive states.
We've actually fixed this! We hope. For the last month or so, we've been making sure that the volume of the ident is less than half of what it was before. This video is slightly older so will still try to blow your eardrums out, but hopefully you won't run into this with any of our newer stuff. Do let us know if it's still too loud though.
![[LIVE] : ONE ลุมพินี 88 | คู่เอก "ป้อมเพชร vs อัสลามจอน"](http://i.ytimg.com/vi/1ZqTVVbMgbo/mqdefault.jpg)
She is an amazing educator. I am grateful to be able to access high quality lecture like this for free.
I just wish I had a longer lifetime (I just turned 80) because I am always discovering new things I would like to know something about, and the above subject is another! I had never heard of what she is talking about. So I was glad to find out there's a book that will try to enlighten what the lecturer was talking about.
I'm 83...almost-feel like u🎉
Imagine the world we'd craft for ourselves if all science was communicated so brilliantly and unpretentiously. Bravo.
Daniel Holley agreed
Daniel Holley 🍷. Drink to that.
Imagine the world ww'd craft for ourselves, if we just understood that our physical reality is a collective subjection/egregore structure
The problem is that not enough people are hearing it. The communicator is not the problem
I'm here after reading her book "The Epigenetics Revolution" to learn about possible updates in the field since it came out a few years ago. I would highly suggest the book to anyone as I had no background knowledge other than high school Biology and yet every chapter would blow me away.
I absolutely have to watch this again and again. She has few equals in terms of clarity and lucidity. I am going to forward this to my entire family. One of the most interesting topics explained by one of the best presenters.
This has to be one of the most interesting presentations I've seen in a while. Absolutely fascinating.
The most boring presentation. Boring verbal diarrhea and the poor woman is totally confused as to the meaning of Epigenetic. What saves her is the cute accent. She is trully the product of Rockefeller education system. Sad.
@@gracegwozdz8185. Well that’s a rather pretentious comment, given that she is an expert in epigenetics. Perhaps you would care to enlighten us with your wisdom on where she went wrong?
@@Pseudify david it seems worthless showing any sort of interest in these comments since it only demonstrates her mindset..or rather choice of one.
I'm currently reading 'Junk DNA' and I can assure you that it is really informative and it doesn't bore you. As a first-year medical college student, it is really helpful to visualize the epigenetic differentiation. Examples she gives are hilarious.
God does not make junk. Scientists don't know it's purpose so it is automatically relegated to the junk heap.
Amazing lecture! She takes complicated information and breaks it down into interesting info using jokes, history, stories, movies and more! Brilliant!
I scored rotten childhood, alcoholism, diabetes, 40yrs depression. My parents died 2012. I went outside and stood in the sun. Instant relief then happiness. Counselling and diagnosed as having aspergers (3yrs old emotionally top 2% computational brain). I took up Zentangling Art and I am still changing & growing. It took 20 yrs after MtDna test for me to find a living relative and I discovered that 5 gens back my ancestor came from Sweden who was a Sami. I then discovered I had inherited characteristics from that cultures but not in the same configuration. I bought a good copy of the I Ching and asked HOW I could bring information from the MtDna into my conciousness. The answer was hexagram 19. It told me not to think about it or ask another question and when I asked another question I was told to not do that again. This is simplified. The overall answer was that the answer was approaching. Sooooo... I bought a book on epigenetics, wrote to a scientist and I find your teaching style that puts the text books I am reading into context. I am 72 and am like a teenager. THANK you so much.
The 8 proteins are histones and form a protein complex known as a histone octamer, which is spool shaped (marshmallows were used in the demonstration). The 8 proteins in the histone octamer are actually 2 copies of 4 proteins, H2A, H2B, H3 and H4. DNA wraps around the histone octamer known as a nucleosome and they form chains like beads on a string making up chromatin. A nucleosome can be defined as a small length of DNA wrapped around eight histone proteins. The key difference between chromatin and nucleosome is that chromatin is a whole structure of complex DNA and proteins while nucleosome is a basic unit of chromatin. The beads on a string make up something called euchromatin or open chromatin that is enriched in genes and active under transcription (transfer of genetic instructions) which is why it is so important in epigenetics and changes in the phenotype (physical traits- e.g. appearance).
Thanks professor 😂
This was the the biggest eye opener for me in the past years. This knowledge opens so many doors.
We really need epigenetics to advance as a civilization, some might even say it's... nessacarey
Yes - but we need the right stimulus; and that can come only from the WORD of GOD, found in the Bible. We could easily deteriorate into barbarism, especially if we start copying animals, instead of reminding ourselves that we are made in the image of GOD.
Eyes Open!
Caleb Smit I see what you did there 😂😂😂👍
Amazing
Well done
What an incredible communicator. Science needs many more with her skill.
Dude, she is a fun and exciting person to give lectures! I can listen to her talk about science all day!!!
How fortunate that I in india can access this extraordinary lecture delivered so well and generously sprinkled with humor. Great contribution to science education. Have her books which are so precious for me
Reading her book now after watching this a few months ago! Brilliant and exciting literature! Epigenetics is such a fascinating field! This is telling us how we can affect our future progeny!
Name of the book?
The Epigenetic Revolution by Nessa Carey@@Anonymous-zy3lh
Her book, The Epigenetics Revolution, is fantastic by the way.
She destroys it. Good talk. Her book gets a bit complicated at times but this is spot on.
I would very much like to hear professor Carey's view on the mRNA vaccines and their potential influence on the human epigenetics!
Its all actually very simple to understand when you grasp what is actually occurring in terms of epigentics and how we are products of evolution - genetics and events - what we do and what is done to us
If for whatever reason molecular biology doesn't work out for Nessa Carey, she can surely do well as a stand-up comedian! Very entertaining and enlightening talk!
Wonderful talk! I can't get enough of these Royal Institution lectures.
How does mitochondrial DNA affect heredity, and how can you tell?
SO intriguing! How the things, habits, nutrients we do now can genetically modify our future progeny!
Crocodiles and Dinosaurs share a common ancestor, crocs are not descended directly from dinosaurs.
Brilliant talk, especially your dna analogies
Absolutely brilliant presentation. I just wanted to learn a little for my pathophysiology class and left amazed!
Superb presentation skills! Just the right amount of humor, story telling and information transfer to resonate with almost everyone.
Wow😂
You make it so easy to absorb! You're an amazing professor! Thank you!
fantastic delivery of a fantastically fascinating subject -- thoroughly enjoyable, especially being a twin myself.
First time i am watching her. Today I purchased her book " The Epigenetics Revolution. Not my subject. But i have interest.
Happy to watch. Thank you Madam. Regards
So much to love about this. Even all these years later rewatching it still give me all those uh-huh feelings.
Outstanding presentation
Showed this video to a friend. She responded, "it's true with exception to Mary, the mother of Jesus".
Extremely clarifying presentation, her book is also a gem of science communication...
Great video! Increasingly our behavior determines our longevity. Just as weight scales provide transparency and motivate dieting, epigenetic tests now make biological age (as distinct from chronological age) more transparent and motivate us to adopt right behaviors to help us live longer.
This is absolutely incredible! I'm completely floored.
Her explanation about stress and childhood experiences is interesting. I was very fortunate because I had a pretty stable, happy childhood with a protective father who thought I was a piece of gold and a loving mother who was a great nurturer. Even though I was overweight and constantly bullied, I retained my happiness and confidence that has allowed me to be successful in my career and personal life. I am married to a great person, but have noticed that he is usually depressed and insecure. His sister has finally admitted that out of 6 siblings, he was given the least amount of attention and praise and was often criticized. This was needed information for me as his spouse because I can now understand why he rather that I remain overweight. When I lost most of my weight, my husband would exhibit jealousy and insecurity. He would retreat into his den, and not talk to me. Now that I have lost my mobility, my husband seems happy which I find hurtful, but with theory, I have learned that he feels empowered because he feels no one will find me attractive and he can now be the only person I can depend
Emotional abuse and neglect to keep you overweight to maintain his own well-being. Understanding his behaviour should not excuse it.
One of the best speakers I've seen on this channel. We need more sweets-based analogies in scientific discourse.
Andri Eiríksson something with chocolate in it would be nice.
She is long-winded and boring.
What a wonderful (and delicious!) lecture! I am enraptured by her humour and her passion. What a shame I am watching this 9 years after the release of the original video.
Fascinating, fascinating, fascinating. Absolutely fascinating.
What a BRILLIANT educated and informative video, love it!
Nice. But molecular genetics was already about gene expression regulation, in bacteria, at the start. Sex is a molecular dialog and it has probably many and variate levels of (self) interpretation. I have discovered computer science in the working of the DNA of Escherichia Coli, a long time ago (Jacob & Monod mainly).
Fascinating subject, i'd never heard of this subject before. Props to the lecturer for giving such an entertaining lecture on a complicated subject! I hope you have her back again.
Excellent if you do it everyday in your practice with quantum
I'd love her as a professor for all my bio classes
I wonder how many people who watched this wished their jobs required them to play with candy in order to do it effectively? I think a lot of companies wouldn't be so stuffy if they allowed their workers to play with candy sometimes...
Great presentation. And she's just a natural. Very entertaining. 🙂
thank you so very much. This is wonderful. I am glad to say I was wrong.
A great way to transmit knowledge
Finally! we have an exciting, summation of information about this field! Thank you for posting. Best explanations, clear analogies and diagrams I've ever found .I've been interested in this field for many years, though no longer a formal student. This great video brings me up to date.
We need more real scientist dedicated to discover and instructs and inform us broadly . Thank Madam
All I want to do right now is eat strawberry laces and jelly tots.....on a serious note, this lecture was FASCINATING - thank you Nessa for your fabulous energy teaching this
Oh no! Your exposure to the video (environmental factor) has changed your mental content, which could change your behaviour which could change your epigenetics, which could change the future of your offspring?
Good grief this rabbit hole goes deep...
The DNA code starts from the same then the coding changes but the DNA coding is all the same in the start of the code. Example is like computer coding.
Code DNAMOMDAD then add on EYESLASHES or DNADADMOM Liver etc etc. It's so damn AMAZING
Extraordinary lecture, thank you. blessings, Kimmy
Amazing teaching learning knowledge about the modification and genetic codes sequence of genome 🙏🙏👏👏❤️❤️💐💐
There's one thing I am confused about. So if the histones are wrapped around our genes, and say you become a smoker (but no one in your family tree extending hundreds of years smoked) and the chemical tag is added to the histones to make that gene become 'expressed', does that mean that the 'smoker gene' is predetermined? In other words, will I have a 'smoking gene' by default that is turned off, but will only be turned on if I smoke?
Its really a great lecture never had idea management student can enjoy science.
Would a babies/child’s dna receptors be affected/changed by a traumatic birth experience?
Ie would a more ‘relaxed’, non stressfull/traumatic birth experience have a better outcome for a child later in
Life?
I would love to know the other side of the experiment, where mice with caring mothers were put with not so caring mothers and then had a traumatized life. What happens when a mice with a not so caring mother is put with a caring mother? They get better? They get "normal"? They don't get better?
I don't know where to ask this question :( If someone could give me a clue, i would be very grateful.
Thank Nessa, it is my pleasure to attend your tutorial today at MCRS
So well done. Answered questions I didn't know I had.
🪄✨ Made with SummarizeYT
0:49 - The human genome sequence was first released in 2001, causing a huge hoopla.
2:03 - Epigenetic phenomena have been known for a long time but were not given much attention.
3:00 - Laboratory mice with the same genetic background can have different weights due to epigenetic factors.
5:01 - Gender in crocodiles is determined by the temperature at which the eggs develop, not genetics.
6:01 - Different cell types in our body have the same DNA code but exhibit different characteristics.
8:08 - Epigenetics plays a crucial role in gene expression and can be influenced by external factors.
12:00 - Epigenetic modifications can switch genes on and off, leading to different gene expressions.
14:00 - Epigenetic modifications can be compared to different flavors of jelly tots, introducing flexibility in gene expression.
16:15 - Epigenetic modifications can also compact DNA, permanently switching off gene expression.
17:27 - Epigenetic modifications can go wrong and contribute to diseases like cancer and diabetes.
19:01 - Children who have experienced abuse or trauma in their childhood are more likely to develop chronic diseases later in life.
20:07 - Epigenetics can influence what happens in organisms without altering the DNA sequence.
20:42 - Baby rats that are loved and cared for by their mothers have low levels of stress hormones.
22:03 - Epigenetic modifications in rats can be passed down from generation to generation.
24:01 - Epigenetic information is necessary for mammalian reproduction.
26:41 - Epigenetic changes can result in significant differences in physical characteristics, as seen in agouti mice.
30:03 - Mice can learn to associate a smell with something negative, and this fear response can be passed on to their offspring.
31:43 - Lamarck's theory of acquired characteristics is not entirely accurate, but epigenetic changes can be influenced by the environment.
34:01 - Trauma experienced by male mice can be passed on to their offspring.
35:05 - Epigenetic changes can affect the offspring's physical characteristics, as seen in the experiment with female mice.
36:03 - Identical twins can have different outcomes due to epigenetic changes.
so the dna is still the same, just the little "jelly" dots that attach to the dna that a person might develop while interacting with his environment? But what's the mechanism behind the epigenetic changes (my guess it's still the DNA that gives instructions to the protein to make the epigenetic changes)...I mean could epigenetic changes lead to the eventual creation of a new species? Thinking more ahead, how much can we augment our body through tweaking the expression of various genes, like would we be able to grow a new arm through epigenetics, or is that sort of mutation still dependent on the manipulation of DNA? You say that the little "jelly" dots, sorry I forget the exact term you used for those molecules, attach to the genes and affect their individual expression, but how many genes do we have, what are each gene's functionalities, how does each gene interact with each other, and what explains the difference between us and a chimp or a bird or something? God damn it get more research done lady!
My back is hurting from watching all these Royal Institute videos laying on my bed at 1AM in California, and I also don't have a car to go to work tomorrow morning, and I think it'd be really nice if DNA technology can allow me to grow a pair of wings! (though the image might be a bit grotesque) so I can fly around to work and buy groceries or something...
To those enthusiasts who have this presentation: please go and read the two books. But you have to read both.
I wonder what the "mild stressful stimulus" of slavery passed from generation to generation.....
This... allllll of this!
Thanks for making it easy to understand
Such an amazing talk ma'am..really really loved it to the core...
Mary Poppins is awesome at science!!
It would be interesting to know what foods could turn on or turn off gene expression in humans and the outcome of the change.
An awesome presentation.
First-rate presentation on this topic. Thanks very much.
Outstanding presentation. Very clear. Congratulations!!!!
This is EPIC!! Lamarck is partly vindicated, but that's the least of it. We are more "adjustable" than we realized before, and some of these adjustments can be passed on to the next generation. LOTS to think about, even for the ordinary person in the street who wants their offspring to be healthy and talented.
all i can give to this lady is 🙇 Respect! amaizing
Actually I wouldn't say it's a new field of biology but rather one we just found out about lol ... super interesting
Interesting topic, delightful presentation.
1:16 for a believer crediting or thanking God doesn't mean discrediting or not thanking scientists.
In all biology textbooks, Galapagos finches are mentioned as a prime example of evolution. However, a relatively recent study conducted by Peter and Rose-Marie Grant documents that the changes in beak size and shape of these birds that Darwin observed do not take millions of years, but change continuously at a rapid rate of as little as two years and that the changes are reversible. It is very likely that it is epigenetic adaptation, not evolution in the Darwinian sense. This certainly also applies in many other cases where adaptation is interpreted as macroevolution today. The theory of evolution must and will be rewritten.
Watch Bruce Lipton - he goes straight to the point. She’s funny but it’s taken too long to explain it.
Wow, really enjoyed this lecture. Any sociological/psychological applications or assumptions linked to these findings? ie, poverty, oppression, consistent trauma etc...
Thank you for the very fascinating and lively lecture! I love it!
Well worth the listen! Thank you mame
Really good - packed with interesting insights and good for the RI to tackle what is admittedly a controversial topic.
Great video! I can imagine that practical living advice can come from epigenetics, like how i can change my own in a positive way. Any chance to get that?
Hmm, for example if you don't smoke, your epigenetics for requesting more nicotin don't get switched on and your kids probably won't smoke either. Does this answer your question?
Fantastic, Love the energy your brought to your book The Epigenetics Revolution"
I wonder if you can see the link between Epigenetics and Buddhist Karma.
(They are both very deep matters)
Any Buddhist's out there pls read this and think....
excellent video to describe epigentics, its a subject i wanted to write on next for my blog.
Unfortunately she was not able to explain how homeostasis knows which genes to turn on and off. Or how a certain chemical affects certain genes and not others. Are certain aspects of evolution Lemarkian? Evolution takes place because of needs and choices? Do epigenetic changes eventually lead to sequence changes?
Excellent.
I am not much of an animal lover but I began to feel more and more uncomfortable at the descriptions of the animal experiments.
Also when she describes epigenetic modifications I thought she committed the "Time Machine" error in that she described it rather than explained.
Nevertheless a superb piece of education for me by a brilliant teacher!
Science.. devil's play ground
How would you explain a Monarch Butterfly’s migration from central Mexico to Canada and back to the same tree? There are four generations in a year. The migration is a year long. The returning butterfly is the great grandchild of the one that left the overwintering tree. How is the information passed on through the generations?
Alex Chen Birds rub themselves against certain trees to leave a trace, so that might be it.
Butterflies experience reincarnation! Duh!
Great presentation 👏
I hope everyone enjoyed this.
How are crocodiles descended from dinosaurs? They were around at the same time weren't they?
there is probably an error factor of plus/minus a few million years...
The same way the US is descended from the UK even though they exist separately and at the same time.
@@hayuseen6683 No, crocodiles and dinosaurs share a common ancestor but they don't "descend" from one another (That honour corresponds to birds, aka avian dinosaurs). If you want to put in geographical terms, they're like Serbia and Slovenia sharing an extinct Yugoslavia
While it is true that she made a mistake, this is not a smart argument. Plenty of species of fsh descend from Coelicanth but it's still here
Thank you for great presentation! Ive been thinking about one question. In the "bullied" mouse experiment epigenetics were not transmitted but in cherry blossom smell, the fear was transmitted to offspting due to epigenetics. Is that a contradiction that in some cases environmental quality gets passed in others not?
Fascinating.
Interesting material and very well done presentation.
Nithya
Intellectual, Kindle the mind to know more about epigenetics Thanks
Very nice video and a good, yet brief presentation. I wonder what sense is actually used in the female to identify that the male was traumatized and causes the offspring to be runts. Of course I do not expect some active cognitive process of the female. But I would run the experiment over and over again with a blind, then a deaf, then an asomnic (is that word even correct?), etc. female mice, also combinations of these senses. Being unscientific now, I imagine that smell could be the important sense here, but that is pure speculation and this approach (guessing) is not scientific at all.
This talk made me think. I was born premature and would not survive without modern medicine (in the 1980s). My parents told me how hard it was for them to see this tiny helpless being enclosed in an incubator, they could not hold it in their arms, cuddle with it. Now I hear in this video that mice who were less loved tend to be more depressed. So naturally I wonder if there is any connection to myself now, as in my very first days of life I was inside an artificial environment, connected to hoses (my lungs were not fully developed at that time). I tended to be "cloudy" more than my brother and peers during childhood and even now many people tell me that I am a pessimist and sometimes that I am depressed (and frankly I feel that too, but do not recognize it as a serious problem yet).
This thoughts could well be just confirmation bias of a speculation. Nevertheless, it makes me think broader now. Conclusions? None. I am not an expert in this at all and actually cannot do anything about it, so why bother about some hastened amateur conclusion? It does not make life easier. But as we say in my native language, the bug is successfully planted in my head. Meaning that this idea (or meme if you want) which came out of pure speculation is in my memory and I will have to live with it from now on. I can just hope to forget it, or at least not be reminded too often about that. I hate my brain, it makes me remember unpleasant and/or embarrassing memories all the time.
I too wondered the same about the mice, would love a link to that experiment and more. I think depression has more to do with early childhood and less to do with the infant years......my sister is prone to depression and a few of my friends, and after years of observing and analyzing them and why and when they get depressed it usually has to a lot to do with being or feeling inadequate or unaccomplished in life.....my sister grew up with higher expectations from my parents than I did and I see that with my friends as well....in turn I don't let failures get me down probably because my folks were more relaxed about my shortcomings and so I take life in strides and it us what it is. When I talked with my sister about this at first she denied it, but over the years she has finally accepted this and started changing her own expectations for herself and worked on not caring how others view her or her accomplishments....what a difference it has made in her getting depressed....she is more happy and enjoying life. Hope that helps you with your depressive states.
Always love a new RI video, always get annoyed about the huge difference between the sound level of the title credit and the lecture itself.
We've actually fixed this! We hope. For the last month or so, we've been making sure that the volume of the ident is less than half of what it was before. This video is slightly older so will still try to blow your eardrums out, but hopefully you won't run into this with any of our newer stuff. Do let us know if it's still too loud though.
What a brilliant lady!
Just when we thought we've found the answer in genetics, epigenetics happened!😢
Can we ever fully understand anything??
Crocodilians are not descendants of dinosaurs. They coevolved. Correct me if I'm wrong.