Epigenetics
ฝัง
- เผยแพร่เมื่อ 5 มิ.ย. 2024
- You know all about how DNA bases can code for an organism's traits, but did you know there's more influencing phenotype than just the bases? Explore epigenetics with the Amoeba Sisters by learning about a few types of epigenetic marks and some examples of them in action.
Contents:
00:00 Intro
2:14 Epigenetic Marks
4:13 Studies Involving Rodents & Epigenetics
5:51 Points about Inheritance and Factors Involving Inheritance
7:01 Why study Epigentics?
7:51 Epigentic Therapy
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REFERENCES:
Clark, Mary Ann, Matthew Douglas, and Jung Choi. “16.3 Eukaryotic Epigenetic Gene Regulation- Biology 2e | OpenStax.” Biology 2e. OpenStax, March 28, 2018. openstax.org/books/biology-2e...
Klug, William S, Michael R Cummings, Charlotte A Spencer, Michael Angelo Palladino, and Darrell Killian. Essentials of Genetics. Hoboken: Pearson, 2020.
Adams, J. (2008) Obesity, epigenetics, and gene regulation. Nature Education 1(1):128
www.nature.com/scitable/topic...
Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004 Aug;7(8):847-54. doi: 10.1038/nn1276. Epub 2004 Jun 27. PMID: 15220929.
pubmed.ncbi.nlm.nih.gov/15220...
Robert A. Waterland, Randy L. Jirtle
Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
Molecular and Cellular Biology Aug 2003, 23 (15) 5293-5300; DOI: 10.1128/MCB.23.15.5293-5300.2003
mcb.asm.org/content/23/15/5293
Dana C. Dolinoy, Dale Huang, Randy L. Jirtle
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
Proceedings of the National Academy of Sciences Aug 2007, 104 (32) 13056-13061; DOI: 10.1073/pnas.0703739104 www.pnas.org/content/104/32/1...
Simmons, D. (2008) Epigenetic influence and disease. Nature Education 1(1):6
www.nature.com/scitable/topic...
Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013). Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(1), 111-123. doi.org/10.1038/npp.2012.149
Oomen, M. E., & Dekker, J. (2017). Epigenetic characteristics of the mitotic chromosome in 1D and 3D. Critical reviews in biochemistry and molecular biology, 52(2), 185-204. doi.org/10.1080/10409238.2017...
www.cdc.gov/genomics/disease/...
www.sciencemag.org/news/1997/...
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FURTHER READING SUGGESTIONS:
This website is phenomenal for learning about epigenetics, and it was recommended in Pinky’s graduate course.
learn.genetics.utah.edu/conte...
More about histones?
www.nature.com/scitable/defin...
Why did we write the words “some exceptions” when mentioning that methyl groups generally prevent transcription? More info: www.ncbi.nlm.nih.gov/pmc/arti...
We mention these are only some examples of epigenetic marks. What others exist? Check out this further reading which mentions Micro-RNAs.
journals.physiology.org/doi/f...
What do we mean about epigenetic tags being “cleared?” Two great further readings:
learn.genetics.utah.edu/conte...
science.sciencemag.org/conten...
Epigenetic therapy with diseases?
www.ncbi.nlm.nih.gov/pmc/arti...
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MUSIC:
Intro music designed & performed by Jeremiah Cheshire.
End music listed free to use/no attribution required from TH-cam audio library.
TRANSLATIONS:
Turkish Subtitles by Kardelen Karaman
We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. You can submit translated subtitles here: www.amoebasisters.com/pinkys-...
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Pinky! This is one of my favorite topics too. Have you read about the Dutch Hunger Winter? Or learned about how the fetus's size is affected by epigenetic markers from mom and dad? Fascinating stuff.
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This video is so interesting. Since middle school to undergrad I have never heard any teacher talk about this and I actually randomly stumbled across it while reviewing for a genetics exam so thanks! Biology is finally a not repetitive science to learn about
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Excellent videos!! I have used quite a few of them as teaching basis and will not hesitate to do it again! Just like many high-school curiculae, you are often focused on human physiology and related subjects, which is perfectly understandable. Sometimes you also venture into evolutionary biology, which is really great! But if you want to go a bit beyond, I would suggest that you dive into invertebrates (keep off the boring insects!)... -there are so many different subjects to look into while trying to step away from the (somewhat limiting) "human" perspektive. Lots of subjets to look into, morphology, reproduction, development, parasitism, feeding biology etc etc... -best wishes from Denmark
Thank you so much! Starting Epigenetics module and this gave me a head start before I dive deep!
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Thank you so much for including references!
I just love your voice pinky, it is so clam and it is just funny and cute when your voice change because you are excited and interested about something. i honestly don't care about epigenetics much, i don't even study it right now, just came to drop a like and say 'Thank you so much' you deserve a million subscribers and more! keep up the good work!!
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Great timing^^
Learnt about this in my intro to psych class and boy was I blown away
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Great video, explaining nicely a really important topic!
This is a very important topic, thanks so much.
I’ve gotten interested in epigenetics this year so I’m super excited for this video, thanks Amoeba Sisters!! ♥️🔬
My high school students when they start biology class: "We already did Punnett Squares in middle school, so I basically already know everything about genetics."
Me: "Oh you sweet summer child...."
i just want to say that you guys have helped me so much in hs and you're still helping me in university🥰🥰
😊
Ameobas thank u so much for your effort and simplification of such advanced topics)))))
I’m here b/c the prf recommended viewing this vid in BIO 350 today, human genetics. I noticed a glib on your about me, thought I would share that these vids are definitely being used at the college level. BMB 300 had one of your vids at the beginning of the semester too.
Excellent presentation..... a little too fast but excellent. When I was a pre dental student the the University of South Florida ( 1965-1969 ) we had an excellent biology teacher ( Dr. Jerome Krivanick ). Through his lectures I acquired a lifelong interest in biology. Epigenetics was in it's primitive state at this time but just when you think you know it all things change and our minds expand.
From the author of the book " Understanding First Class Dental Care" ( Amazon ) and the founder of the David Hamilton Projesct.
hello! im learning the nervous system now, i was wondering if you could make a video about that? your videos always help me understand better!
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So even if we perfectly clone someone as a child, there's a chance that epigenetics will make them different as they grow older?
That's crazy
The environment (childhood eternal influences) as well as she said :) which is highly unlikely to be perfectly duplicated to get a near identical clone. Hence again why twins can be so vastly different.
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Could you please make a video on animal tissues....
Perhaps you could make 4 videos one on muscular tissues, other one nervous tissue, one on Epidermal tissues and another on connectice tissues...
This would help high schoolers (like me) greatly....
Tysm❤
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