Renue By Science 10% discount code MHS: tinyurl.com/35jyuk33 Lipo NMN tinyurl.com/3wr8pr3t DoNotAge 10% discount code MHS tinyurl.com/6dbvhv87 NMN tinyurl.com/wyzj2f3d ProHealth 15% discount Code MODERN: prohealth.pxf.io/9gVX3e NMN prohealth.pxf.io/Jz4dL2 Nuchido Time+ 20% discount of first purchase with code MODERN20 nuchido.com/MODERN ☕If you would like to support our channel, we’d love a coffee…thank you! www.buymeacoffee.com/mhealthspan
I was in the hospital with covid for a full week. I had covid for 2 weeks before being hospitalized. I wasn't getting better. After a week in the hospital and almost dying, they gave me 4 bags of Remdesivir and it killed the covid. I got to live and was released the next day. I hadn't eaten in in over 3 weeks and lost about 30 pounds. I could barely walk and was extremely weak. 2 years later i was still extremely week. It never went away. I tried exercise but i could barely do anything. The Drs said i had massive damage from low oxygen to my entire body especially my organs. I started looking around for things that helped other people in my exact situation and someone pointed me to NMN and another thing called NAC. I started taking both of them daily and in a week i started feeling normal again. After 2 weeks, i felt strong and started working out again. Whatever is in this stuff, it actually works. No Doctor was able to help me and i was just written off.
Good to know it is not just my imagination. I started NMN just over a year ago. My hair has become darker and the wrinkles around my eyes have decreased quite a bit. So far so good. Thanks for your update.
Hope the same happens for me🙂. I’m about 5mths behind you guys. My hair is thickening but haven’t noticed colour change & have not noticed any skin / wrinkle improvements at all. This is comforting
@@RoscoeDaMule approximately 1gram a day, to boost it I also take 1gram of TMG, and trans-resveratrol. Hope this helps. Aside note- I have been giving 1/2 those dosages to my 13 year old dog. He has responded very well and is more energetic. He also receives sulforaphane each day to lower his risk of cancer (which is a major killer of dogs). Another supplement you might want to look at is Ca-AKG. Research indicates it greatly improves healthfulness as mammals age.
6 months on nmn, tmg, resveratrol, and isagenesis by isagenix has reversed gray hair except for some of beard. I am a 66 year old man,mostly vegan, daily sauna use. I was out with a 63 year old lady friend and was asked twice if she was my mom. The regimen has doubled EFGR, improved eyesight, feeling great, more energy stamina.
I am 63 and promise you you would be asked if I am your daughter. I’ve been at this since I was 25 and began using the protocols of Durk Pearson based largely upon anti oxidant science and then the science since then that is so useful - to say the least. This is not self flattery or wishful thinking. I have been very self disciplined and the pay offs have been profound.
This return of your wife’s cycle is astounding and the implications of this to improved human health & health span cannot be overstated. Something like this will tend to be under played if not ignored in main stream science for the obvious reasons. You are reporting exactly the type if info that is pure gold to me and I so appreciate every iota of it. Many thanks and you must continue. Subscribed.
One thing to note is that Richard's wife had very recently gone through the first phase of menopause whereby her periods had stopped. Results might not be the same for women with a longer gap between their last period and taking NMN as my reading suggests that the number if eggs continues to reduce each year and there are a finite number.
@@juliepowell2572 Yeah but whatever you do try to avoid heavy bone loss in the 10 years after menopause. It could really take you by surprise. That's the worst part!
Richard, this is so helpful to me. As a woman of 58 and beginning this journey with you and your wife, it would be very helpful to know your wife’s age as well. We’re all friends here….
2:30 - it looks like your age reversal reached a plateau at 9 month. It's interesting to see whether the effect is transient or long term. The ultimate test is how long lifespan can be extended and the quality of daily life at the same time. Really appreciate for sharing your experience!
Is there a risk that restoration of menstruation in elderly women would bring a set of its own problems. It happens. We need to watch out. The concept of age reversal is in conflict with the human evolutionary history so it will face hurdles and limitations. We need to be on guard for them. Being cautiously optimistic is critical. Humans have never conquered nature. That is not going to be exception either.
@@sleepsmartsmashstress740 'Elderly'? My great grandma never got elderly. She won many a ballroom dance trophy, right up to the week of her death. She died in her sleep, looking 55, at the age of 119!
@@staceykersting705 While this would be just too good be true we should all aim for such aging. The age related suffering would be gone and a lot of the problems of a aging society (e.g. overloaded medical and nursing resources) would be lessened. Charles Eugster showed similar benefits, there is also an interview of Linus Pauling in his mid-90ies (I think), a year before he died, in which he looked like a mid-70 man with an enthusiasm and energy of a 30 year old...
Thank you so much for posting such indepth results..My wife is currently perimenoposal so this gives us hope that Nmn can help her.I have been using Nmn,resveatrol and Tmg for about 4 weeks now and i feel more energetic so im very enthused about these longevity supplements. Please keep posting Richard
Great job structuring the video. I really appreciate all the information. I am trying to get my 61 year old dad started on NMN and other supplements. He has depression and anxiety for a decade now and he has aged faster than he should have..
Good to keep us updated on your wife's updates. I feel her journey is so similar to mine. I also suffer from allergies and my period has increased from menopause state. Hope you keep us updated on her results. Thanks
Hi Lorraine, thank you for your kind comment. I shall update her status in our next report. BTW, we have a new interview series with Dr. Wahls, the latest video is about healing autoimmune through Diet, please take a look in case you havent. th-cam.com/video/XZX9bwqYKhY/w-d-xo.html
Congratulations Richard, great achievement over the year. Thank you for sharing all your progress. As tha saying goes, "picture speak a 1000 words", your pictures say it all. My dad (67 yrs) is taking NMN along with multiple other supplements for about 2 months now and he feels lot more energy and lot less sleepy in afternoon, he is sharper when it comes to his work as well and best of all his sugar levels are in lot more control. Your channel has been very helpful in my search for such supplements. Happy new year and hope 2021 becomes even healthier and happier.
Hi Ankur, Happy New Year to you too and we wish the best health for you and your dad. Really good to hear that the NMN is working for him and interesting to hear that it appears to also be helping with his sugar levels.
Super interesting, I'm on NMN as well. My new growth hair turn out to be thicker and darker. Absolutely will follow you and your wife journey to see! BTW, great report, informative but not boring at all!
@@JoJo-hp5qd would taking the powder break a fast? I don’t eat breakfast and I wonder if taking these break your fast. Any information would be a great help. Thanks!
Thanks so much for these videos on NMN Richard. I started taking NMN in early May. I have been dealing with long Covid symptoms (most notably fatigue, shortness of breath and brain fog) for over 2 years now. I was not hospitalized but was asymptomatic. I noticed a big change once I started NMN. It helped get rid of the fatigue. I tried many other things such as B complex vitamins and even more coffee but I would find myself still getting tired very early in the day. It has helped my brain fog a bit. I've tried to post in support groups about NMN and even in TH-cam comments and much of the time my posts/comments are removed. I really think it would help many more people with long Covid if they knew about it. I'm not quite back to normal yet but I'm much improved from a year ago. That's incredible that it reversed your wife's menopause!!
Thank you for the comprehensive report, it's really a good reference. It's encouraging to hear your result as I'm on nmn supplements as well. Please continue post your result, thanks.
Oh my goodness! This is AWESOME! I am so excited about this info. I have been trying to find a way to hold back menopause or reverse it completely. I have tried many supplements and diet, but nothing is working that well so far. I am going to give your protocol a try. THANK YOU for posting this!
Hi Rececca, thank you for your supportive comment! Frankly speaking, I did a bit hesitate whether post this topic out or not, but my wife think maybe helpful to some other ladies who has same situation. FYR, one of our audience commented she use fish Oil successfully reverse her menopause as well.
Menopause was the best thing tha ever happened to me! I had no negative side effects. Only thing that happened was...no more periods! also, don't miss the unpredictable mood swings. Why-o-why wd anyone want their period back? I was SO happy when mine stopped! Menopause particularly enhanced my sex drive, since it removed the fear of pregnancy. I could never have imagined how freeing this was!
It did mine also (reversed perimenopause). Literally zero symptoms since the first dose of sublingual NMN. At the time it was powder form from Renue by Science, now the pills in addition to LIPO tablets. Good stuff.
@@annak7939 I think it was about 1 g at the time. (I'm taking 650 mg now in a combo of sublingual powder pills and LIPO tablets.) The effect will wear off eventually and I'm not interested in periods forever anyway, but it still does suppress the symptoms of menopause. I'm going to try a senolytic (maybe fisetin?) next....Let me know how it goes !
David Sinclair takes 1000 mg of NMN so I began taking that amount in the mornings and could not sleep for days. I have cut it down to 500 mg in mornings and still have energy all day and trouble sleeping. I have not consumed caffeine in years. Other than excessive energy, I have not noticed any other changes in 4 months. I also take resveratrol and krill and b12(shot). I have followed a strict diet (no sugar, grains, processed foods) for years. Photo is last year at 70 yrs old.
Well done Richard so informative, I've followed you and your wifes progress from the beginning so couldn't click on this quick enough, what remarkable results your both experiencing, I'm currently coming up to my year anniversary on the protocol and I'm also seeing my own results, I had a two week break in December due to having a delay in my NMN being delivered and noticed within a few days my tiredness increasing in the afternoon resulting in me having to nap which I had eradicated during the time of taking NMN, I will continue to follow you and your wife's progress with great interest, happy new year to you both.
Absolutely FANTASTIC how you graphed your biological age change along with NMN dosage and supplement form. Glad to see a positive response from just capsules as i don't have the patience for 'sublingual' absorption. Ive tried sublingual by opening a capsule and putting powder under the tongue, i didn't like it, took a long time. A lozenge is a good idea though.
May i suggest taking Organic Beef liver capsules. They are an excellent source of Vit A which is essential for healthy skin, vision, and enhancing immune health. Liver capsules are also a high source of B12 & Folate so I no longer buy the supplement i used to take for those vitamins, as i get a good natural dose from the liver capsule + Vit A. Of course you could just eat liver meat which is far cheaper than capsules, but i hate the taste personally.
Thank you Richard for sharing your journey. I've only recently become aware of the science of anti-aging, NAD, and supplements such as NMN and Resveratrol. You have inspired me to continue delving deeper into this topic and am anxious to give NMN a try.
For your wife's rash I would highly recommend B3 (Niacin) at 500 mg once or twice a day. The B3 will generate facial flushing (this lasts about most 45 min- totally harmless). She should also take alpha-R-lipoic acid 300 mg 1x or 2x per day. She should see results within a week. Best wishes
As I mentioned in the video, She's taking NMN about 10 months, overall she's more energetic but seems not helping her allergy much. She never try Niacin before, May I ask why you think Niacin works for her allergy ? She stopped most supplements last few months after reading your comment, she said she might start ALA again to see. Thank you!
@@ModernHealthspan Hi again. Sorry my response has taken so long. Niacin helps in the rejuvenation of myelin around peripheral nerves. You can look up this paper. Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. In other readings I've found that peripheral nerves can influence rashes. So, my hope is that stabilizing peripheral nerves may help reduce the allergic effect. I've found the combination of B3 and ALA has helped me. Of course all of this may be individual specific. Hope this helps.
Thank you for the detailed update on your progress Richard. I agree you look substantially better than your initial experiments back in 2019: you've clearly lost excess weight, your skin looks younger and more vibrant and your hair looks improved too. Of course, much of that could come from taking regular collagen (I assume peptides), but it does seem reasonable to suppose that the NMN is also playing an important contributory role. Here's to an update in a year and two from now when we'll hopefully all be able to better conclude the efficacy or otherwise of this longevity experiment you are running. My own stack is larger than yours but broadly in the same direction.
Hi David P, good to hear from you again, thank you for your supportive comment. I remember you started almost same time as us or a bit earlier? Great to hear you are in a good progress as well. Please update us more when you have time.
If there are any eating disorder cognitions or perhaps some fears of foods,because of several adverse reactions & allergies, there's help. Encourage her to stop losing any further weight and restore above BMI 20. Thank you and best wishes for you both
Thank you for your video. I got my products today. And like your wife I hope to get positive results I am looking forward to your additional postings. 👍👍
Has your wife taken an ovulation test? Normally if you are having a period, you are ovulating but I would be very curious if she tested that, what the result would be.
@@jasonblahafitness9637 Zero gains from what, using bands? You're trolling I hope! Check out Jeff Cavaliere or even Sly Stallone if you are not convinced. Unless you own a gym and are scared of losing customers which I understand, but stop trolling and misinforming people unless you really are that ignorant!
For the allergies , i suggest Quercetin EMIQ type , if not Desloratadine anti histamines which makes her not tired or sleepy as it crosses not the blood brain barrier unlike the standard loratadine or other anti histamines ✌️
Great video By the way for ur wife meno. Pause reversal, have u measured her AMH ( Anti murulin hormone) level before starting NMN n after 1 year. What is the comparison this may show real picture on level of reversal of menopause as it shows ovarian reserve
Very good question, I wish she would get a hormone panel and see the levels if they have all returned to pre menopause levels.... that is why I asked earlier if she has taken an ovulation test to see if she is actually ovulating.
I am concerned about the period of not taking NMN. Your wife's epigenetic age quickly resumed to the level it must had been before taking NMN. So it seems NMN only makes one younger while it is being taken. Perhaps we should not exogenously raise the levels of NAD+ with a precursor, but stimulate the subsystem in our body that makes more NAD+. I mean quite a bit like taking 5-HTP vs taking an SSRI. Then later when endogenous NAD+ stimulation is possible, one could develop drugs that can keep that (semi-)permanent.
Thanks for all the hard work and reportage, but, my friend, in order to do a clean clear essay of the effect of nmn, you need to have no other variables, and you have so many that it becomes boggling. Best to try again another time!
I have recently found out I have new several health conditions and now menopausal. Its affecting my work. I am going to try this. Can you give us an update on your wife's menopause?
Prebiotic fiber is very helpful. I'd recommend oat fiber over acacai. Oat is full of immune boosting beta glucans. In particular, you might see your lymphocyte/monocyte ratio go up after using it. (There's such a correlation in my data). Great job!
Hi. I'm taking QUERCETIN plant based DAILY. I take dried parsley in my food. I also drink chamomile tea with MCT. I ENJOY STRAWBERRIES WITH PLAIN YOGURT AS A DESERT. THANK U FOR YOU INFO.
I am 56 year old Asian man. I began to take NMN with Resveratrol two months ago. Prior to taking it, I had a frequent urination problem with insomnia. Now these problems are all gone. NMN is a miracle drug..I guess. But I heard that you have to choose a good NMN with high percentage of purity.....so choose the best NMN product
Thank you for the presentation. It's informative. It's encouraging to see that your wife's period is back. Does she continue to have regular period? What is her actually age (if you do mind to tell)? Do you think it's due to NMN or Resveratrol? I am considering to take NMN and Resveratrol to see if it will bring back my period also.
@@staceykersting705 it's not just the period though it's the whole effects of reversing menopause. I'd have a period til I die if I can avoid menopause!!
Hi Richard, your videos are really informative. Congratulations for your channel. The only downside is that we can not tell whether your amazing improvement are due to NMN, or to changes in your diet, other supplements, and exercises . Anyway, the combination of all seems to have great benefits, and there is obviously the great benefit that NMN have shown in animal models. Please keep updating us on your progress.
Hi Curious minds, thank you for your comment! As the ultimate goal of taking NMN to us is getting healthier and younger! So definitely other than NMN, we'll still continue our healthy diet and exercises, or even incorporate any new supplements or regimen which will help us to achieve this after our detailed research, for example, CD38 inhibitor, apiginen which we recently added!
She should start doing prolonged fasts. I have contact eczema and although I still get the allergy if I come into contact with chemicals (especially my hands), the body clears them immediately (one to two days). I take NMN but I also do prolonged fasting 24-48 hours weekly. The body is able to contain the allergy very quickly with prolonged fasting.
It appears your wife is gluten sensitive and histamine sensitive. She may benefit from taking an enzyme supplement DAO. This can breakdown excess histamine if taken prior to eating and potentially after eating. If it is histamine smoked meats and fermented products will cause her rash as well as avocado and corn. Histamine sensitivity often accompanies gluten sensitivity. Best wishes, Tim
Hi Tim, thank you so much for your comment. My wife and I really appreciate it. You are observe well it seems she's histamine sensitive and the IgG test she took recently shows she has food tolerate on gluten, dairy & soy. She bought DAO supplement from seeking health already. Yes, she loved fermented foods and avocado, but now she need to stop eating them.
Richard - thanks so much for this update. I really appreciated the breakout on the different forms of NMN along with the other specifics. Curious if you will make any changes on your NMN form moving forward?
Hi Vince, thanks for your comment and question. We are thinking of trying the powder form again when we finish the enhanced absorption. Probably just take it dissolved in water. It will be interesting to see what the next age result shows
Thanks. This confirms I shouldn't take it since I'm a breast cancer survivor and had an oestrogen-fuelled cancer. NMN is clearly raising oestrogen levels which is a risk factor for oestrogen breast cancers.
The primary risk of NMN supplementation (or NR), is the depletion of the methyl group ‘pool’ on which many aspects of your metabolism interact and modulating your DNA expression, It is possible to replenish the cellular methyl pool exogenously via supplementation
Nice, I started with NMN about 3 months ago, and my sleeping went from 3 to 4 hours every other night to 6 to 7 hours every night, with yawns and all at 21.30! Also, my very white grey hair started darkening from the roots a few weeks ago. Curious where that is going. ☺️
Amazing report! It is very encouraging. It might give me a chance to convince my wife to start taking these supplements too. Thank you a lot. By the way, you do look younger
Thank you for sharing that about your wife, l started taking NMN. I am menopausal, my last period stopped when l was 61 and l started having my period again, it is very light not intense like when l was younger.
I would suggest adding assays of inflammation if you can find an affordable one for healthy people. My supplement list is much different with similar improvements with one assay of low inflammation. Working on senescence, autophagy, mitochondria, and gut lining health would probably expand your supplement list. I'll look into methylation clock tests.
Hey Richard, excellent video! btw, have you ever come across a study (or maybe Sinclair has concluded from many studies combined) that compares the nicotinic acid vs NMN effectiveness to NAD+ production? In know niacin is less effective... but how much less?
Nice report your certainly looking younger and your wife's cycle data is astonishing. I myself have started taking nuchido time plus. I would be very interested if you could do a video on this. It's supposed to increase nad levels much more the mnm? It's very difficult to know what's best to do. But for sure we need to be doing something as diet and exercise is not going to cut it long term.
Hi Anthony, thanks for your comment and suggestion. I have not tried Nuchido so it would be difficult to make a video on them. In terms of the claim to increase NAD levels more than NMN I do not see references on their website that I could look up to further investigate. Can I ask how long you have been taking Nuchido? Would you be able to share your experience? It would be great to hear how it is going for you.
Richard, thanks very much for your data and sharing, it is good to see you get good result from NMN, and I am going to take it after seeing your video. Anyway, looking forward to your update video.
Nice one Richard and to your wife! I will be purchasing NMN soon. I've also commented that your skin/hair looks better in a previous video recently. This may be of interest - David Sinclair also uses a moisturiser with resveratrol in it, which he helped developed. He never gave the brand name in the interview, but a google search found it. I heard about Dual-N-Back about 3 years ago and I started doing it for a while, but honestly I hated it so much that I stopped. Back then they claimed it improved 'fluid intelligence'. I wonder if the results from the paper been replicated (i'll find out after this). Working memory improvements would be good for myself and I probably have more to gain in this area. Your biological age increased slightly (on a downwards curve though?), did anything change for you during this period? less exercise, too much exercise, bad stress, easing on the diet, sleep issues, toxins (unlikely due to your wifes general sensitivities).
just finished listening to the last minute of your video to which you say covid interfered with your access to the gym, which in part answers my question i think.
Hi thanks for your comments and sharing. Interesting about Dr. Sinclair using resveratrol on the skin. WRT Dual N Back, as I recall the claim was that it improved your fluid intelligence by increasing your working memory. Yes my biological age did tick up in the last test. In general no major issues during this time, though as you noted exercise has been intermittent. It may be the precision of the tests and is just part of the normal variance. It will be interesting to see the results of the next test which we should be doing soon.
@@ModernHealthspan www.nature.com/articles/s41598-020-77310-9 I found this article, which I guess indicates it could be a worthwhile effort to complete Dual-N-Back.
I think my question on short term impacts has been well covered anecdotally below. Thanks. I am 3 weeks in, so will feed back in due course. It is my 65th birthday in 5 weeks, and I set myself a goal of doing a half Marathon on my birthday - I accomplished that yesterday. I slightly accelerated my training - not super clever - but was pain-free and tip top today. Again, Richard, thanks for your diligent efforts; an excellent complement to the professor stuff.
@@Corrans, did half marathon 5 weeks early. I am certain I have seen a fairly immediate jump in both alertness and decisiveness. Also, sensitivity in knees, shoulders and wrists seems better: broken plank records and can now sleep on my sides again. Sleeping was much longer and better, but now awake and getting up at 5-6am - not necessarily what I want. I was sleeping a great 8 hrs, after correction for habitual wake-up after about 5 hours. All anecdotal input, but seems real
@@dandunleavy3011 May I ask what dosage of NMN you take? So far in South Africa, I can only find two brands, one of 120mg and the other 250mg. I could take more than one capsule, I guess.
Thank you for sharing sir!! Do you use keffir as probiotic? May be at certain age is ok, but we must be careful with the protein intake for the mTor and so... May be eating complex carbs along with an amylase blocker is the way to go as you will kill your hunger with way less calories intake and lower the insulin to acceptable levels while not falling into the protein excess that comes along with low carb diet plus you will be feeding nicely your gut bacteria (I think saw a paper saying that amylase blocker were good for gut bacteria) But I don't know... Edit : very gentleman like you didn't show your wife's age 😄
I take prebiotics twice a day for my diverticulitis and kefir for friendly bacteria but sorry couldn't' understand well enough " did you mean eat more protein with good carbs" Sorry it's my English.Thanks. Every little info is helpful so I don't want to ignore or miss them.God Bless🙏
@@semaaral2498 there's a good amount of studies and literature that study the relationship between protein restriction and longevity, I am not an expert so I can not tell you nothing you shut consider seriously. Sorry :)
It sounds like your wife may have chronic autoimmune urticaria. It usually lasts for 1-2 years, is totally unexplainable as far as actual irritants, then disappears. It isn’t an allergy although it seems to be. A 7 day water fast with electrolytes under Doctor supervision also helped me. My hives and rashes are completely gone now for over a year.
High doses of omega 3 to balance the 3-6 ratio will lower her inflammation. I have had customers that have completely got rid of their psoriasis and other inflammation and auto immune diseases. They have taken tests before and after to confirm their omega 3-6 ratio and often we see this come down from 1:8 up to 1:16 down to 1:3 . As for her elimination diet I suggest reading "The plant paradox" As well as "fast this way" And "superhuman" Just to get a better understanding of the body and what we can do to be our best 💯
Great report, Richard! Thank you for sharing. I'm very interested in Longevity. Although I cannot afford supplements, I'm trying Keto diet, Intermetting fasting, and beggining Interval training :)
Hi tachijardon, thank you for your comment! You regimen is pretty good, other than keto, we are on fasting and interval training as well. Dr. Lustgarten is also try to optimal his longevity mainly through diet and exercises and he works quite well. His interview series is on, please take a look in case you haven't:-)
Sometimes I wonder if NMN is just an expensive non-flush version of niacin, especially since this paper was published that found most NMN gets converted to nicotinic acid riboside and enters the same pathway as niacin, not the salvage pathway of which NMN is an intermediary. There was also a trial long ago, before stating, that looked at niacin for cholesterol control, then a decade later they did a follow and saw a significant reduction in all cause mortality in the group that had received niacin (3dd 1g for around 6 years) The good thing is niacin is really cheap but if you ever decide to take it, take the flush version not the non-flush which can be hepatotoxic
I can't find your wife's age in here. That said, it's not unusual to have periods return for a while after they have apparently stopped, until they finally stop completely. It will be more significant if they continue after another year. But NMN is fantastic. I'm almost 69, have been taking NMN almost a year and have more energy than I have EVER had. I've never been an athletic person, rather curl up with a book. Now I can't wait to exercise. The only thing, if I don't exercise I don't feel much effect from the NMN. If I do exercise, it multiplies the effect of the NMN, and the NMN multiplies the effect of the exercise. In my experience, you have to exercise to really trigger the rejuvenating effect of NMN. NMN and exercise are synergistic.
Hi Richard, I really enjoyed your update video. I was just wondering why you changed from the powder form to sublingual and then to enhanced absorption capsule. Did you find one works better than the other?
Richard: thank you for your update! Since you mentioned your concern on liver functions and your wife's skin issues, I'd like to suggest hyperbaric oxygen therapy (HBOT) at home, which improves all kinds of things, especially the liver and the skin. My family is experimenting with HBOT and seeing rapid improvements in skin condition, GI function, injury healing, and more. I just bought the epigenetic test you used to further track our progress. Wish I watched your video earlier and bought the test sooner.
Has your wife thought about brand of washing up liquid potentially being a cause to some of her insensitivity's? Small amounts do get left on plates and pots and pans, which can get ingested. Me and wife have recently used a castile soap, hot water, and bicarb mix as an alternative (and elbow grease). A bit different, as this is not ingestion based - two years ago I randomly got eczema on my hands and wrists. In the end, extra strong steroid cream reduced it, but never completely (and you can only use it for a few weeks). So after stopping the steroids - the thing that eliminated the eczema for me was using gloves while washing dishes (helped to clear 80%), and then finally I stopped using Aussi brand shampoo (helped to clear 100%) - I used no shampoo and just rinsed every day instead. cleared it up within a couple of weeks. I now use shampoo, just a different brand.
Hi, thanks for sharing your experience, very interesting. We do use ordinary washing up liquid, but my wife always use gloves if she does the washing up. Castile soap looks interesting. For shampoo we have an organic shampoo and soap from the same company which seems to work quite well for her skin and we have seen some improvement.
1) Thanks for making and posting your video, and the earlier updates. 2) "Menstruating" again after menopause might indicate the reversal of menopause (as has been seen in some animals given NMN) -- that's great if it's what your wife is experiencing. But it could also be a sign of a health problem. Just to be on the safe side, I assume she's been seen by a health professional.
Hi Pathways to Longevity, thank you for your kind comment and consideration. We did consider visit her doctor from the beginning but at that time HK has riots all the time, we didn't get chance to go. Actually before our 3 month's report, her menopause come back already, but at that time we are not sure it's really reverse or something else. So we didn't mention it. Now, her period comes regularly for over 10 months already, so we think it's fine. BTW, other than her we did heard a couple of cases also reverse menopause by NMN.
@@ModernHealthspan Are these comments written by the same person who did the video?????? Your English in written form is very different to that in your videos. The grammar feels very second language. So confused.
Richard, have tried signing up for the Levels product to continuously monitor your glucose levels? This would be interesting data to add to this impressive journey you and your wife are on. Thank you for sharing.
Hi DJ, thanks for your suggestion. Some form of continuous glucose monitor is on our wish list, though have not got there yet. The Levels plan does look interesting. We will add it to the CGMs that we look at.
I started Resveratrol 4 mnths ago, Nmn 3 months ago and Tmg 1 week ago. I am 55 years old and had no period for almost a year. However my period came back a month after taking Nmn, at first it was normal cycle of 28 days, but this time I got it again after 2 weeks. Not sure if Tmg played a role in it, would really appreciate some advice 🙏 I have to add that my energy levels have increased, my grey hair started getting darker, and my skin is more hydrated and clearer.
Thanks for your comprehensive update. Two questions. First, does low dosage of nmn like 150mg per day actually work(vs taking higher dosage), just at a slower pace? Second I feel a warm all over body sensation when taking nmn + resveratrol. Does this mean it is revving some kind of metabolic function?
NMN is related to niacin so I would assume the warmth is just improved circulation / mild flushing. 150mg should work though the energy boost may be milder.
Cleaning products and washing you hands with hot water will do disasters to your hands, I suggest you wife starts there. Taking care of that and using moisturizing creams worked great for me. There's also a nice protective cream for when going out sold under Invisible Gloves, that will protect from sanitizers.
I noticed that over time you increased your dosage of NMN. I have only been on it for 3 months and I noticed that my fatigue is coming back. It makes me think that maybe the body develops a tolerance for it.
@@tenzindolma6266 sorry for the late response. I forgot to reply. I was taking 1 mg of NMN, NAC, Resveratrol (to make NMN more effective). I had been taking Vedicinals 9 from a German-Indian company that helped, also saw a homeopath who gave me a homeopathic remedy for long Covid as well. Everything helped, even without NMN and NAC now, I don't have fatigue anymore. My stamina when running is still not as good as pre-pandemic. I don't have much brain fog anymore. I'm trying other things like vagus nerve stimulation.
@@TraderCat.8763 "For those taking NMN regularly, I recommend no less than 50% of your NMN intake matched with an equivalent dose of TMG." "If you have been taking NMN for a long period, it might be a good precaution to take TMG to prevent any potential methylation issues. In short, methylation is a crucial biochemical process that occurs in every cell in the body and our bodies have a pool of molecules called methyl groups that it uses for this process. If there is a lack of methyl groups, the body might not be able to perform all the critical functions of methylation which could lead to health conditions. When NMN is converted into NAD+, nicotinamide (NAM) is formed. High levels of nicotinamide are bad for our bodies and in order for our bodies to get rid of it, it needs to be methylated into N-methyl nicotinamide, that’s then excreted and, in order to do that, the body draws on our pool of methyl groups. However, this might cause a lack of methyl groups to perform all the other critical functions that require methylation. To prevent this from happening, you can take TMG which donates a methyl group. It’s important to note that in a podcast with Dr. Mercola, Dr. Sinclair mentioned that he takes TMG only as a precaution because the research is unclear at this stage." The internet suggests TMG might be wise if you're taking NMN.
I’ve read that the body converts retinol/vitamin A into uric acid. I’ve also noticed that my hair is darker in the last couple of months supplementing resveratrol and quercetin. thanks for the videos.
Thank you for sharing your update. In the past, you have said your wife didn’t want her chronological age mentioned. Does she feel the same way? Reason being, I try to compare my numbers to hers (as she’s female). I don’t know if I’m comparing correctly. If it helps, I’m 45 🙂. Either way, really appreciate that you share your data 🙏
Thanks for making this video! Your results are very interesting. Based on your data, it seems that the powder/capsule form was better than the sublingual, but your wife's results show that there was no difference whether ingested in powder/capsule form vs sublingual. Is this correct, or did I misread your results. I'm taking NMN and have heard different views on how to take it so I ingest some with olive oil and I take some sublingually.
Richard, the NMN process is logically a long term winding back of clock: widespread across body cells and progressive within a given cell. However, you have also experienced short term reactions: your resumption of napping when your supplies ran out; realtime influence on menstration. Do you have any explanation for this? For my own part, I am in my second week, but right from start, I have felt energised - this is also pretty immediate. At six months, you reported you were delighted with so much progress. I was delighted within 24 hours - trying to get my head around this apparent dual speed impact.
You also pointed out immediacy of your wife's puzzle scores to NMN. On other hand, David Sinclair's dad rang David after 6 months to report on noticeable change........
Hi Tony, Thanks for your question. I don't believe so, I certainly take it daily and as the aim is to boost my NAD levels I think that makes sense. I have heard on one of Dr. Sinclair's podcasts how he fed his mice resveratrol every other day, which seemed to have a better effect (however I was not sure this was because the mice were doing intermittent fasting or because the resveratrol was given to them on alternate days)
@@ModernHealthspan Thank you for taking the time to answer my question, Richard. You hit my point about when Dr Sinclair fed his mice Resveratrol every other day 👏🏼 very smart! At what age you think I should consider taking NMN? (I am 41 years old)
@@tonymrad0019 Hi Tony, thanks for the question. NAD continues to go down as you age and by 50 you have half the levels of your youth. You can see here www.researchgate.net/figure/Correlation-between-NAD-levels-and-Age-in-A-Males-B-Females-A-NAD-concentrations_fig8_230590378 that the decline is gradual over time and so is probably happening when you are 41.
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I was in the hospital with covid for a full week. I had covid for 2 weeks before being hospitalized. I wasn't getting better. After a week in the hospital and almost dying, they gave me 4 bags of Remdesivir and it killed the covid. I got to live and was released the next day. I hadn't eaten in in over 3 weeks and lost about 30 pounds. I could barely walk and was extremely weak. 2 years later i was still extremely week. It never went away. I tried exercise but i could barely do anything. The Drs said i had massive damage from low oxygen to my entire body especially my organs. I started looking around for things that helped other people in my exact situation and someone pointed me to NMN and another thing called NAC. I started taking both of them daily and in a week i started feeling normal again. After 2 weeks, i felt strong and started working out again. Whatever is in this stuff, it actually works. No Doctor was able to help me and i was just written off.
Those doctors should have given you Ivermectin
@@a.leehilliard4716But then it would go against the establishment🙄
@@a.leehilliard4716 Yeah, I took it and stopped it in one day.
Good to know it is not just my imagination. I started NMN just over a year ago. My hair has become darker and the wrinkles around my eyes have decreased quite a bit. So far so good. Thanks for your update.
And did u feel youthful.coz this nmn is like super food
Hope the same happens for me🙂. I’m about 5mths behind you guys. My hair is thickening but haven’t noticed colour change & have not noticed any skin / wrinkle improvements at all. This is comforting
at what doseage? may I ask
@@RoscoeDaMule approximately 1gram a day, to boost it I also take 1gram of TMG, and trans-resveratrol. Hope this helps.
Aside note- I have been giving 1/2 those dosages to my 13 year old dog. He has responded very well and is more energetic. He also receives sulforaphane each day to lower his risk of cancer (which is a major killer of dogs).
Another supplement you might want to look at is Ca-AKG. Research indicates it greatly improves healthfulness as mammals age.
As an aside I'm 74 and I have been taking 300mg of NR for four months and my hair has noticeably darkened and I do have more energy in the afternoon.
6 months on nmn, tmg, resveratrol, and isagenesis by isagenix has reversed gray hair except for some of beard. I am a 66 year old man,mostly vegan, daily sauna use. I was out with a 63 year old lady friend and was asked twice if she was my mom. The regimen has doubled EFGR, improved eyesight, feeling great, more energy stamina.
Brilliant just Brilliant.
Hi Kenneth, thanks for sharing and great that you are seeing such good results!
Thank you for sharing. I always wondered why David Sinclair wasn't grey at all.
I am 63 and promise you you would be asked if I am your daughter. I’ve been at this since I was 25 and began using the protocols of Durk Pearson based largely upon anti oxidant science and then the science since then that is so useful - to say the least. This is not self flattery or wishful thinking. I have been very self disciplined and the pay offs have been profound.
@@rs5570 No one knew about NMN when you were 25
I started my period again at age 57! I have been post menopausal since 38!
Are you serious? How long were you in it before u started your period?
What dose are u taking please
@@monkeybearmax Approximately 9 months.
@@inassfikri2534 NMN / TMG / Resveratrol Power 1000mg daily. Spermadine, Quercetin, Melatonin, Metforin, Bio-Fisetin, Vitamins B12, D & C. Liquid Collagen. Magnesium, HRT, Milk Thistle, Zinc, Selinium, DIM & Saw Pametto. It's alot.. but there you go.
Any updates?
🥰
This return of your wife’s cycle is astounding and the implications of this to improved human health & health span cannot be overstated. Something like this will tend to be under played if not ignored in main stream science for the obvious reasons. You are reporting exactly the type if info that is pure gold to me and I so appreciate every iota of it. Many thanks and you must continue. Subscribed.
What obvious reasons?
Let's keep this a secret from the Kill Bill😄
One thing to note is that Richard's wife had very recently gone through the first phase of menopause whereby her periods had stopped. Results might not be the same for women with a longer gap between their last period and taking NMN as my reading suggests that the number if eggs continues to reduce each year and there are a finite number.
I hope so because I really don't want my period back!
@@juliepowell2572 Yeah but whatever you do try to avoid heavy bone loss in the 10 years after menopause. It could really take you by surprise. That's the worst part!
Richard, this is so helpful to me. As a woman of 58 and beginning this journey with you and your wife, it would be very helpful to know your wife’s age as well. We’re all friends here….
Yes, it's a little suspicious that he didn't tell her age. Maybe she's 40 so it's totally normal to have her periods ''back''.
@@cailllou25 yep no periods for 1 yr before a women is technically in menopause.
@@cailllou25 40 is too young for her and her friends to be having menopause.
She is in her 50s. Are you looking for someone to relate to?
He's around 70 & his wife is 50s. What is this desperation to know age?
2:30 - it looks like your age reversal reached a plateau at 9 month. It's interesting to see whether the effect is transient or long term. The ultimate test is how long lifespan can be extended and the quality of daily life at the same time. Really appreciate for sharing your experience!
It's not the years but it's the quality of life. I like to play tennis like I was 10yrs ago. 😮😂
I am following your progress with interest. The update on your wife's menstrual cycle is fascinating. Many thanks for sharing.
Hi Ann, thanks for the support!
That scared me off the stuff. Sprinted into the kitchen and chucked it in the bin! I can't believe anyone wd want their period back! Yikes!
Is there a risk that restoration of menstruation in elderly women would bring a set of its own problems. It happens. We need to watch out. The concept of age reversal is in conflict with the human evolutionary history so it will face hurdles and limitations. We need to be on guard for them. Being cautiously optimistic is critical. Humans have never conquered nature. That is not going to be exception either.
@@sleepsmartsmashstress740 'Elderly'? My great grandma never got elderly. She won many a ballroom dance trophy, right up to the week of her death. She died in her sleep, looking 55, at the age of 119!
@@staceykersting705 While this would be just too good be true we should all aim for such aging. The age related suffering would be gone and a lot of the problems of a aging society (e.g. overloaded medical and nursing resources) would be lessened.
Charles Eugster showed similar benefits, there is also an interview of Linus Pauling in his mid-90ies (I think), a year before he died, in which he looked like a mid-70 man with an enthusiasm and energy of a 30 year old...
Thank you so much for posting such indepth results..My wife is currently perimenoposal so this gives us hope that Nmn can help her.I have been using Nmn,resveatrol and Tmg for about 4 weeks now and i feel more energetic so im very enthused about these longevity supplements.
Please keep posting Richard
Did nmn helped your wife ?
Great job structuring the video. I really appreciate all the information. I am trying to get my 61 year old dad started on NMN and other supplements. He has depression and anxiety for a decade now and he has aged faster than he should have..
Hey, how has it gone? :)
Promising result and you documented it so well. Thank you Richard!
HI Mark, thank you for your encouraging comment!
Good to keep us updated on your wife's updates. I feel her journey is so similar to mine. I also suffer from allergies and my period has increased from menopause state. Hope you keep us updated on her results. Thanks
Hi Lorraine, thank you for your kind comment. I shall update her status in our next report. BTW, we have a new interview series with Dr. Wahls, the latest video is about healing autoimmune through Diet, please take a look in case you havent. th-cam.com/video/XZX9bwqYKhY/w-d-xo.html
How old where you when your period returned?
Is there any change in progesterone levels after NMN supplementation ? Does it increase low progesterone levels for someone in perimenopause?
I started 2 months ago and the results are incredible, my husband's hair and skin look 5 years younger!
Wow!! What brand do you use?
Congratulations Richard, great achievement over the year. Thank you for sharing all your progress. As tha saying goes, "picture speak a 1000 words", your pictures say it all. My dad (67 yrs) is taking NMN along with multiple other supplements for about 2 months now and he feels lot more energy and lot less sleepy in afternoon, he is sharper when it comes to his work as well and best of all his sugar levels are in lot more control. Your channel has been very helpful in my search for such supplements. Happy new year and hope 2021 becomes even healthier and happier.
Hi Ankur, Happy New Year to you too and we wish the best health for you and your dad. Really good to hear that the NMN is working for him and interesting to hear that it appears to also be helping with his sugar levels.
Hello Ankur. Can u say from where u find nmn nd resvertol in India. Is it available online. Pls suggest
@@MayankJairaj thkns
Super interesting, I'm on NMN as well. My new growth hair turn out to be thicker and darker. Absolutely will follow you and your wife journey to see! BTW, great report, informative but not boring at all!
Hi Jose, glad you like our videos, and thank you for your continuous support!
@@JoJo-hp5qd Hi Jojo
How do you take it (nmn & resverstrol) on the same day, do you take both at the same time, or take it at different times ?
@@JoJo-hp5qd thank you so much
@@JoJo-hp5qd would taking the powder break a fast? I don’t eat breakfast and I wonder if taking these break your fast. Any information would be a great help. Thanks!
@@JoJo-hp5qd thank you for your advise!
Thanks so much for these videos on NMN Richard. I started taking NMN in early May. I have been dealing with long Covid symptoms (most notably fatigue, shortness of breath and brain fog) for over 2 years now. I was not hospitalized but was asymptomatic. I noticed a big change once I started NMN. It helped get rid of the fatigue. I tried many other things such as B complex vitamins and even more coffee but I would find myself still getting tired very early in the day. It has helped my brain fog a bit. I've tried to post in support groups about NMN and even in TH-cam comments and much of the time my posts/comments are removed. I really think it would help many more people with long Covid if they knew about it. I'm not quite back to normal yet but I'm much improved from a year ago.
That's incredible that it reversed your wife's menopause!!
look into NAC ,
@@jerryhyland1554 yep have been taking that too.
Thank you so much for sharing your experience! :) All best wishes ^_^
Thank you for the comprehensive report, it's really a good reference. It's encouraging to hear your result as I'm on nmn supplements as well. Please continue post your result, thanks.
Hi Ray, thanks for your encouraging comments! We will be sure to post our updates.
Oh my goodness! This is AWESOME! I am so excited about this info. I have been trying to find a way to hold back menopause or reverse it completely. I have tried many supplements and diet, but nothing is working that well so far. I am going to give your protocol a try. THANK YOU for posting this!
Hi Rececca, thank you for your supportive comment! Frankly speaking, I did a bit hesitate whether post this topic out or not, but my wife think maybe helpful to some other ladies who has same situation. FYR, one of our audience commented she use fish Oil successfully reverse her menopause as well.
@@ModernHealthspan How much fish oil did she take a day to achieve this?
Menopause was the best thing tha ever happened to me! I had no negative side effects. Only thing that happened was...no more periods! also, don't miss the unpredictable mood swings. Why-o-why wd anyone want their period back? I was SO happy when mine stopped! Menopause particularly enhanced my sex drive, since it removed the fear of pregnancy. I could never have imagined how freeing this was!
did it work on menopause ?
Fascinating update, Richard. Thank You for sharing.
Hi Melissa, thanks for your kind comments!
It did mine also (reversed perimenopause). Literally zero symptoms since the first dose of sublingual NMN. At the time it was powder form from Renue by Science, now the pills in addition to LIPO tablets. Good stuff.
How high dose of Nmn are you taking? Would like to see if I can reverse my menopause. Thank you!
@@annak7939 I think it was about 1 g at the time. (I'm taking 650 mg now in a combo of sublingual powder pills and LIPO tablets.) The effect will wear off eventually and I'm not interested in periods forever anyway, but it still does suppress the symptoms of menopause. I'm going to try a senolytic (maybe fisetin?) next....Let me know how it goes !
I’m not sure where to begin! I’m 42 with chronic fatigue. Should i start with NMN? This is all so confusing!
Did you check your ovulation? Can you still get pregnant?
@@Calmerthanyouare17 take sea salt with honey in a glass of water. X4 per day. Saved my life from cf
It would be good to know your wife's age and see how long after menopause the cycle could return.
David Sinclair takes 1000 mg of NMN so I began taking that amount in the mornings and could not sleep for days. I have cut it down to 500 mg in mornings and still have energy all day and trouble sleeping. I have not consumed caffeine in years. Other than excessive energy, I have not noticed any other changes in 4 months. I also take resveratrol and krill and b12(shot). I have followed a strict diet (no sugar, grains, processed foods) for years. Photo is last year at 70 yrs old.
You look great . But be careful its all under testing.
Well done Richard so informative, I've followed you and your wifes progress from the beginning so couldn't click on this quick enough, what remarkable results your both experiencing, I'm currently coming up to my year anniversary on the protocol and I'm also seeing my own results, I had a two week break in December due to having a delay in my NMN being delivered and noticed within a few days my tiredness increasing in the afternoon resulting in me having to nap which I had eradicated during the time of taking NMN, I will continue to follow you and your wife's progress with great interest, happy new year to you both.
Hi Mia, thank you for sharing and your kind comments. I agree, I also notice energy levels drop when I don't have my NMN. Happy New Year to you too!
Absolutely FANTASTIC how you graphed your biological age change along with NMN dosage and supplement form. Glad to see a positive response from just capsules as i don't have the patience for 'sublingual' absorption. Ive tried sublingual by opening a capsule and putting powder under the tongue, i didn't like it, took a long time. A lozenge is a good idea though.
May i suggest taking Organic Beef liver capsules.
They are an excellent source of Vit A which is essential for healthy skin, vision, and enhancing immune health. Liver capsules are also a high source of B12 & Folate so I no longer buy the supplement i used to take for those vitamins, as i get a good natural dose from the liver capsule + Vit A.
Of course you could just eat liver meat which is far cheaper than capsules, but i hate the taste personally.
Thank you Richard for sharing your journey. I've only recently become aware of the science of anti-aging, NAD, and supplements such as NMN and Resveratrol. You have inspired me to continue delving deeper into this topic and am anxious to give NMN a try.
Hi June, thank you for your comment. Please do share your experience if you decide to proceed with NMN.
Yeah do it June ! I want beautiful women to live 4 ever . . .
For your wife's rash I would highly recommend B3 (Niacin) at 500 mg once or twice a day. The B3 will generate facial flushing (this lasts about most 45 min- totally harmless). She should also take alpha-R-lipoic acid 300 mg 1x or 2x per day. She should see results within a week.
Best wishes
As I mentioned in the video, She's taking NMN about 10 months, overall she's more energetic but seems not helping her allergy much. She never try Niacin before, May I ask why you think Niacin works for her allergy ? She stopped most supplements last few months after reading your comment, she said she might start ALA again to see. Thank you!
@@ModernHealthspan Hi again. Sorry my response has taken so long. Niacin helps in the rejuvenation of myelin around peripheral nerves. You can look up this paper. Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. In other readings I've found that peripheral nerves can influence rashes. So, my hope is that stabilizing peripheral nerves may help reduce the allergic effect. I've found the combination of B3 and ALA has helped me. Of course all of this may be individual specific. Hope this helps.
Thank you for the detailed update on your progress Richard. I agree you look substantially better than your initial experiments back in 2019: you've clearly lost excess weight, your skin looks younger and more vibrant and your hair looks improved too. Of course, much of that could come from taking regular collagen (I assume peptides), but it does seem reasonable to suppose that the NMN is also playing an important contributory role. Here's to an update in a year and two from now when we'll hopefully all be able to better conclude the efficacy or otherwise of this longevity experiment you are running. My own stack is larger than yours but broadly in the same direction.
Hi David P, good to hear from you again, thank you for your supportive comment. I remember you started almost same time as us or a bit earlier? Great to hear you are in a good progress as well. Please update us more when you have time.
If there are any eating disorder cognitions or perhaps some fears of foods,because of several adverse reactions & allergies, there's help. Encourage her to stop losing any further weight and restore above BMI 20. Thank you and best wishes for you both
Thanks so much for the video Richard. You look younger and the data seems to support that...
Hi Tony, thank you for your supportive comment!
Well done, concise and balanced. Thanks for your generous reporting in such a detailed way.
Hi Eugene, thank you for your kind comment. Very glad you like our video, thank you!
You have inspired me to start this longevity journey! Thanks for all of the information.
Thank you for your video. I got my products today. And like your wife I hope to get positive results I am looking forward to your additional postings. 👍👍
Terrific reporting and generally overall a pretty good TH-cam upload! Thanks.. I really enjoyed that. 😀👍
Has your wife taken an ovulation test? Normally if you are having a period, you are ovulating but I would be very curious if she tested that, what the result would be.
Very informative, Good to know about reverse menopause, haven't come to that age yet, but good to prepare. Thank you!
HI Sparkling, thank you for your continuous support!
My period stopping wasthe best thing ever! What a bloody mess THAT was!
Good. Now you get to age 2-3x faster. Enjoy!@staceykersting705
Richard, thank you for providing very comprehensive report for us! This is my 3rd times watching it already!
Hi Susan, thank you to come to our channel again!
You don't have to go to the gym just use high resistance Rubber Bands. They are highly cost-effective. And they can fully replace a gym.
Indeed. A very good option and extremely inexpensive
Try Ashtanga Yoga for home exercise. It is more energetic than it looks. Eddie Stern teaches via Zoom.
And way better on your joints in the long run. I've heard body builders having problems with their joints due to weights/jolting etc
Lol you will get zero gains from that.Non negotiable
@@jasonblahafitness9637 Zero gains from what, using bands? You're trolling I hope! Check out Jeff Cavaliere or even Sly Stallone if you are not convinced. Unless you own a gym and are scared of losing customers which I understand, but stop trolling and misinforming people unless you really are that ignorant!
For the allergies , i suggest Quercetin EMIQ type , if not Desloratadine anti histamines which makes her not tired or sleepy as it crosses not the blood brain barrier unlike the standard loratadine or other anti histamines ✌️
Great video
By the way for ur wife meno. Pause reversal, have u measured her AMH ( Anti murulin hormone) level before starting NMN n after 1 year. What is the comparison this may show real picture on level of reversal of menopause as it shows ovarian reserve
Very good question, I wish she would get a hormone panel and see the levels if they have all returned to pre menopause levels.... that is why I asked earlier if she has taken an ovulation test to see if she is actually ovulating.
I am concerned about the period of not taking NMN. Your wife's epigenetic age quickly resumed to the level it must had been before taking NMN. So it seems NMN only makes one younger while it is being taken. Perhaps we should not exogenously raise the levels of NAD+ with a precursor, but stimulate the subsystem in our body that makes more NAD+. I mean quite a bit like taking 5-HTP vs taking an SSRI. Then later when endogenous NAD+ stimulation is possible, one could develop drugs that can keep that (semi-)permanent.
Thanks for all the hard work and reportage, but, my friend, in order to do a clean clear essay of the effect of nmn, you need to have no other variables, and you have so many that it becomes boggling. Best to try again another time!
I have recently found out I have new several health conditions and now menopausal. Its affecting my work. I am going to try this.
Can you give us an update on your wife's menopause?
any update ?
Prebiotic fiber is very helpful. I'd recommend oat fiber over acacai. Oat is full of immune boosting beta glucans. In particular, you might see your lymphocyte/monocyte ratio go up after using it. (There's such a correlation in my data). Great job!
Hi Gokhan, thanks for the suggestion. We will have a look at this when we are looking for our next fibre supplement
I agree only if its gmo grains
A lot of us do not eat grains. I would rather eat fruit
Hi. I'm taking QUERCETIN plant based DAILY. I take dried parsley in my food. I also drink chamomile tea with MCT. I ENJOY STRAWBERRIES WITH PLAIN YOGURT AS A DESERT. THANK U FOR YOU INFO.
I am 56 year old Asian man. I began to take NMN with Resveratrol two months ago. Prior to taking it, I had a frequent urination problem with insomnia. Now these problems are all gone. NMN is a miracle drug..I guess. But I heard that you have to choose a good NMN with high percentage of purity.....so choose the best NMN product
May I know which brand of NMN you are taking?
Thank you for the presentation. It's informative. It's encouraging to see that your wife's period is back. Does she continue to have regular period? What is her actually age (if you do mind to tell)? Do you think it's due to NMN or Resveratrol? I am considering to take NMN and Resveratrol to see if it will bring back my period also.
Why wd u do THAT? YIKES!
@@staceykersting705 it's not just the period though it's the whole effects of reversing menopause. I'd have a period til I die if I can avoid menopause!!
Great info - thanks for sharing. Looking forward to seeing your results for Year 2 next January 2022.
Hi Jonathan, thanks for you support.
Hi Richard, your videos are really informative. Congratulations for your channel. The only downside is that we can not tell whether your amazing improvement are due to NMN, or to changes in your diet, other supplements, and exercises . Anyway, the combination of all seems to have great benefits, and there is obviously the great benefit that NMN have shown in animal models. Please keep updating us on your progress.
Hi Curious minds, thank you for your comment! As the ultimate goal of taking NMN to us is getting healthier and younger! So definitely other than NMN, we'll still continue our healthy diet and exercises, or even incorporate any new supplements or regimen which will help us to achieve this after our detailed research, for example, CD38 inhibitor, apiginen which we recently added!
She should start doing prolonged fasts. I have contact eczema and although I still get the allergy if I come into contact with chemicals (especially my hands), the body clears them immediately (one to two days). I take NMN but I also do prolonged fasting 24-48 hours weekly. The body is able to contain the allergy very quickly with prolonged fasting.
It appears your wife is gluten sensitive and histamine sensitive. She may benefit from taking an enzyme supplement DAO. This can breakdown excess histamine if taken prior to eating and potentially after eating. If it is histamine smoked meats and fermented products will cause her rash as well as avocado and corn. Histamine sensitivity often accompanies gluten sensitivity.
Best wishes,
Tim
Hi Tim, thank you so much for your comment. My wife and I really appreciate it. You are observe well it seems she's histamine sensitive and the IgG test she took recently shows she has food tolerate on gluten, dairy & soy. She bought DAO supplement from seeking health already. Yes, she loved fermented foods and avocado, but now she need to stop eating them.
This is amazing !! Please keep posting updates. I am gonna start taking nmn.
Richard - thanks so much for this update. I really appreciated the breakout on the different forms of NMN along with the other specifics. Curious if you will make any changes on your NMN form moving forward?
Hi Vince, thanks for your comment and question. We are thinking of trying the powder form again when we finish the enhanced absorption. Probably just take it dissolved in water. It will be interesting to see what the next age result shows
Thanks. This confirms I shouldn't take it since I'm a breast cancer survivor and had an oestrogen-fuelled cancer. NMN is clearly raising oestrogen levels which is a risk factor for oestrogen breast cancers.
The primary risk of NMN supplementation (or NR), is the depletion of the methyl group ‘pool’ on which many aspects of your metabolism interact and modulating your DNA expression, It is possible to replenish the cellular methyl pool exogenously via supplementation
Nice, I started with NMN about 3 months ago, and my sleeping went from 3 to 4 hours every other night to 6 to 7 hours every night, with yawns and all at 21.30!
Also, my very white grey hair started darkening from the roots a few weeks ago. Curious where that is going. ☺️
Brand and dosage
@mariatony40 Dosage please
Amazing report! It is very encouraging. It might give me a chance to convince my wife to start taking these supplements too. Thank you a lot. By the way, you do look younger
Hi Rafeal, Thanks for your kind comments and for sharing.
Thank you for sharing that about your wife, l started taking NMN. I am menopausal, my last period stopped when l was 61 and l started having my period again, it is very light not intense like when l was younger.
I would suggest adding assays of inflammation if you can find an affordable one for healthy people. My supplement list is much different with similar improvements with one assay of low inflammation. Working on senescence, autophagy, mitochondria, and gut lining health would probably expand your supplement list. I'll look into methylation clock tests.
Any recommendations on which NMN and RESVESEROL supplements are the best?
That's what IYE want to know!!
I've started using labdoor to evaluate brands even if their testing coverage is incomplete for now.
NMN from Renue by Science sold by Do Not Age is recommended
Hey Richard, excellent video! btw, have you ever come across a study (or maybe Sinclair has concluded from many studies combined) that compares the nicotinic acid vs NMN effectiveness to NAD+ production?
In know niacin is less effective... but how much less?
just take both
Nice report your certainly looking younger and your wife's cycle data is astonishing.
I myself have started taking nuchido time plus. I would be very interested if you could do a video on this. It's supposed to increase nad levels much more the mnm? It's very difficult to know what's best to do. But for sure we need to be doing something as diet and exercise is not going to cut it long term.
Hi Anthony, thanks for your comment and suggestion. I have not tried Nuchido so it would be difficult to make a video on them. In terms of the claim to increase NAD levels more than NMN I do not see references on their website that I could look up to further investigate. Can I ask how long you have been taking Nuchido? Would you be able to share your experience? It would be great to hear how it is going for you.
Richard, thanks very much for your data and sharing, it is good to see you get good result from NMN, and I am going to take it after seeing your video. Anyway, looking forward to your update video.
Hi Kwong, thank you for your comment. Please update us later on your experience. We shall do the update soon!
Nice one Richard and to your wife! I will be purchasing NMN soon. I've also commented that your skin/hair looks better in a previous video recently. This may be of interest - David Sinclair also uses a moisturiser with resveratrol in it, which he helped developed. He never gave the brand name in the interview, but a google search found it.
I heard about Dual-N-Back about 3 years ago and I started doing it for a while, but honestly I hated it so much that I stopped. Back then they claimed it improved 'fluid intelligence'. I wonder if the results from the paper been replicated (i'll find out after this). Working memory improvements would be good for myself and I probably have more to gain in this area.
Your biological age increased slightly (on a downwards curve though?), did anything change for you during this period? less exercise, too much exercise, bad stress, easing on the diet, sleep issues, toxins (unlikely due to your wifes general sensitivities).
just finished listening to the last minute of your video to which you say covid interfered with your access to the gym, which in part answers my question i think.
Hi thanks for your comments and sharing. Interesting about Dr. Sinclair using resveratrol on the skin. WRT Dual N Back, as I recall the claim was that it improved your fluid intelligence by increasing your working memory.
Yes my biological age did tick up in the last test. In general no major issues during this time, though as you noted exercise has been intermittent. It may be the precision of the tests and is just part of the normal variance. It will be interesting to see the results of the next test which we should be doing soon.
@@ModernHealthspan www.nature.com/articles/s41598-020-77310-9 I found this article, which I guess indicates it could be a worthwhile effort to complete Dual-N-Back.
I think my question on short term impacts has been well covered anecdotally below. Thanks. I am 3 weeks in, so will feed back in due course. It is my 65th birthday in 5 weeks, and I set myself a goal of doing a half Marathon on my birthday - I accomplished that yesterday. I slightly accelerated my training - not super clever - but was pain-free and tip top today. Again, Richard, thanks for your diligent efforts; an excellent complement to the professor stuff.
Please keep us updated.
@@Corrans, did half marathon 5 weeks early. I am certain I have seen a fairly immediate jump in both alertness and decisiveness. Also, sensitivity in knees, shoulders and wrists seems better: broken plank records and can now sleep on my sides again. Sleeping was much longer and better, but now awake and getting up at 5-6am - not necessarily what I want. I was sleeping a great 8 hrs, after correction for habitual wake-up after about 5 hours. All anecdotal input, but seems real
@@dandunleavy3011 May I ask what dosage of NMN you take? So far in South Africa, I can only find two brands, one of 120mg and the other 250mg. I could take more than one capsule, I guess.
@@Corrans 1g, as per DS and Richard
@@Corrans, 1g
Thank you for sharing sir!!
Do you use keffir as probiotic?
May be at certain age is ok, but we must be careful with the protein intake for the mTor and so...
May be eating complex carbs along with an amylase blocker is the way to go as you will kill your hunger with way less calories intake and lower the insulin to acceptable levels while not falling into the protein excess that comes along with low carb diet plus you will be feeding nicely your gut bacteria (I think saw a paper saying that amylase blocker were good for gut bacteria) But I don't know...
Edit : very gentleman like you didn't show your wife's age 😄
I take prebiotics twice a day for my diverticulitis and kefir for friendly bacteria but sorry couldn't' understand well enough " did you mean eat more protein with good carbs"
Sorry it's my English.Thanks.
Every little info is helpful so I don't want to ignore or miss them.God Bless🙏
@@semaaral2498 there's a good amount of studies and literature that study the relationship between protein restriction and longevity, I am not an expert so I can not tell you nothing you shut consider seriously. Sorry :)
It sounds like your wife may have chronic autoimmune urticaria. It usually lasts for 1-2 years, is totally unexplainable as far as actual irritants, then disappears. It isn’t an allergy although it seems to be. A 7 day water fast with electrolytes under Doctor supervision also helped me. My hives and rashes are completely gone now for over a year.
High doses of omega 3 to balance the 3-6 ratio will lower her inflammation.
I have had customers that have completely got rid of their psoriasis and other inflammation and auto immune diseases.
They have taken tests before and after to confirm their omega 3-6 ratio and often we see this come down from 1:8 up to 1:16 down to 1:3 .
As for her elimination diet I suggest reading "The plant paradox" As well as "fast this way" And "superhuman" Just to get a better understanding of the body and what we can do to be our best 💯
Hi Bloodtrax, thanks for sharing. We will try the omega 3. She is already taking some, but maybe not enough. With you on your book selection as well!
Great report, Richard! Thank you for sharing. I'm very interested in Longevity. Although I cannot afford supplements, I'm trying Keto diet, Intermetting fasting, and beggining Interval training :)
Hi tachijardon, thank you for your comment! You regimen is pretty good, other than keto, we are on fasting and interval training as well. Dr. Lustgarten is also try to optimal his longevity mainly through diet and exercises and he works quite well. His interview series is on, please take a look in case you haven't:-)
@@ModernHealthspan
Thanks, Richard, for your answer, I will watch Dr. Lustgarten interviews. Good tip indeed! :)
Sometimes I wonder if NMN is just an expensive non-flush version of niacin, especially since this paper was published that found most NMN gets converted to nicotinic acid riboside and enters the same pathway as niacin, not the salvage pathway of which NMN is an intermediary.
There was also a trial long ago, before stating, that looked at niacin for cholesterol control, then a decade later they did a follow and saw a significant reduction in all cause mortality in the group that had received niacin (3dd 1g for around 6 years)
The good thing is niacin is really cheap but if you ever decide to take it, take the flush version not the non-flush which can be hepatotoxic
@@arhu74 Thanks, Arhu FYI :)
look into poly vagal theory, wimhof/ oxygen therapy etc are all linked to vagus nerve, which are proven to antiage thetelomere
I can't find your wife's age in here. That said, it's not unusual to have periods return for a while after they have apparently stopped, until they finally stop completely. It will be more significant if they continue after another year. But NMN is fantastic. I'm almost 69, have been taking NMN almost a year and have more energy than I have EVER had. I've never been an athletic person, rather curl up with a book. Now I can't wait to exercise. The only thing, if I don't exercise I don't feel much effect from the NMN. If I do exercise, it multiplies the effect of the NMN, and the NMN multiplies the effect of the exercise. In my experience, you have to exercise to really trigger the rejuvenating effect of NMN. NMN and exercise are synergistic.
Thank you for this very useful explanation.will keep in mind and speed up more🙏🌺
Hi Richard, I really enjoyed your update video. I was just wondering why you changed from the powder form to sublingual and then to enhanced absorption capsule. Did you find one works better than the other?
Hi Erin, I was wondering the same thing... Did you get a definitive answer from anywhere?
Richard: thank you for your update! Since you mentioned your concern on liver functions and your wife's skin issues, I'd like to suggest hyperbaric oxygen therapy (HBOT) at home, which improves all kinds of things, especially the liver and the skin. My family is experimenting with HBOT and seeing rapid improvements in skin condition, GI function, injury healing, and more. I just bought the epigenetic test you used to further track our progress. Wish I watched your video earlier and bought the test sooner.
Which hyperbaric machine did you buy?
Has your wife thought about brand of washing up liquid potentially being a cause to some of her insensitivity's? Small amounts do get left on plates and pots and pans, which can get ingested. Me and wife have recently used a castile soap, hot water, and bicarb mix as an alternative (and elbow grease).
A bit different, as this is not ingestion based - two years ago I randomly got eczema on my hands and wrists. In the end, extra strong steroid cream reduced it, but never completely (and you can only use it for a few weeks). So after stopping the steroids - the thing that eliminated the eczema for me was using gloves while washing dishes (helped to clear 80%), and then finally I stopped using Aussi brand shampoo (helped to clear 100%) - I used no shampoo and just rinsed every day instead. cleared it up within a couple of weeks. I now use shampoo, just a different brand.
Hi, thanks for sharing your experience, very interesting. We do use ordinary washing up liquid, but my wife always use gloves if she does the washing up. Castile soap looks interesting. For shampoo we have an organic shampoo and soap from the same company which seems to work quite well for her skin and we have seen some improvement.
'washing up liquid' lololol
1) Thanks for making and posting your video, and the earlier updates.
2) "Menstruating" again after menopause might indicate the reversal of menopause (as has been seen in some animals given NMN) -- that's great if it's what your wife is experiencing. But it could also be a sign of a health problem. Just to be on the safe side, I assume she's been seen by a health professional.
Hi Pathways to Longevity, thank you for your kind comment and consideration. We did consider visit her doctor from the beginning but at that time HK has riots all the time, we didn't get chance to go. Actually before our 3 month's report, her menopause come back already, but at that time we are not sure it's really reverse or something else. So we didn't mention it. Now, her period comes regularly for over 10 months already, so we think it's fine. BTW, other than her we did heard a couple of cases also reverse menopause by NMN.
@@ModernHealthspan Are these comments written by the same person who did the video?????? Your English in written form is very different to that in your videos. The grammar feels very second language. So confused.
Richard, have tried signing up for the Levels product to continuously monitor your glucose levels? This would be interesting data to add to this impressive journey you and your wife are on. Thank you for sharing.
Hi DJ, thanks for your suggestion. Some form of continuous glucose monitor is on our wish list, though have not got there yet. The Levels plan does look interesting. We will add it to the CGMs that we look at.
Excellent work Richard. Thanks.
Hi Raymond, thanks for your kind comments
Hello, very informative, thank you !! Would you have any update on your wife's menopause ? Thank you !
I started Resveratrol 4 mnths ago, Nmn 3 months ago and Tmg 1 week ago. I am 55 years old and had no period for almost a year.
However my period came back a month after taking Nmn, at first it was normal cycle of 28 days, but this time I got it again after 2 weeks. Not sure if Tmg played a role in it, would really appreciate some advice 🙏
I have to add that my energy levels have increased, my grey hair started getting darker, and my skin is more hydrated and clearer.
Brilliant video! Thank you for posting this!😊
Thanks for your comprehensive update. Two questions. First, does low dosage of nmn like 150mg per day actually work(vs taking higher dosage), just at a slower pace? Second I feel a warm all over body sensation when taking nmn + resveratrol. Does this mean it is revving some kind of metabolic function?
NMN is related to niacin so I would assume the warmth is just improved circulation / mild flushing. 150mg should work though the energy boost may be milder.
Cleaning products and washing you hands with hot water will do disasters to your hands, I suggest you wife starts there. Taking care of that and using moisturizing creams worked great for me. There's also a nice protective cream for when going out sold under Invisible Gloves, that will protect from sanitizers.
Very interesting and extremely well documented. Would love a 2022 update!
Excellent report
Hi! Thanks for sharing your experiences. What's the sleep quality app you are using?
Thank you for sharing your journey with us, quite fascinating and thorough info!
Thank you for your encouraging comment!
Richard, can you please link the food sensitivity test? I didn't see it posted. Thank you!
@ModernHealthspan
Great info and update Richard. Thanks for sharing. 👍
Hi Ron, thanks as always for your support!😀
Thank you for the informative videos! And what was the game to improve the mental fitness?
I noticed that over time you increased your dosage of NMN. I have only been on it for 3 months and I noticed that my fatigue is coming back. It makes me think that maybe the body develops a tolerance for it.
What NMN dosage do you take ? Actually, what is all the protocol you take, besides NMN?
@@tenzindolma6266 sorry for the late response. I forgot to reply. I was taking 1 mg of NMN, NAC, Resveratrol (to make NMN more effective). I had been taking Vedicinals 9 from a German-Indian company that helped, also saw a homeopath who gave me a homeopathic remedy for long Covid as well. Everything helped, even without NMN and NAC now, I don't have fatigue anymore. My stamina when running is still not as good as pre-pandemic. I don't have much brain fog anymore. I'm trying other things like vagus nerve stimulation.
@@TraderCat.8763
"For those taking NMN regularly, I recommend no less than 50% of your NMN intake matched with an equivalent dose of TMG."
"If you have been taking NMN for a long period, it might be a good precaution to take TMG to prevent any potential methylation issues. In short, methylation is a crucial biochemical process that occurs in every cell in the body and our bodies have a pool of molecules called methyl groups that it uses for this process. If there is a lack of methyl groups, the body might not be able to perform all the critical functions of methylation which could lead to health conditions.
When NMN is converted into NAD+, nicotinamide (NAM) is formed. High levels of nicotinamide are bad for our bodies and in order for our bodies to get rid of it, it needs to be methylated into N-methyl nicotinamide, that’s then excreted and, in order to do that, the body draws on our pool of methyl groups.
However, this might cause a lack of methyl groups to perform all the other critical functions that require methylation. To prevent this from happening, you can take TMG which donates a methyl group. It’s important to note that in a podcast with Dr. Mercola, Dr. Sinclair mentioned that he takes TMG only as a precaution because the research is unclear at this stage."
The internet suggests TMG might be wise if you're taking NMN.
Just found your channel could you ease tell me which brand you're using as there has been many fakes on Amazon in particular I'm your new subscriber x
Great information and well presented! Thank you for sharing.
I’ve read that the body converts retinol/vitamin A into uric acid. I’ve also noticed that my hair is darker in the last couple of months supplementing resveratrol and quercetin. thanks for the videos.
Thank you for sharing your update. In the past, you have said your wife didn’t want her chronological age mentioned. Does she feel the same way? Reason being, I try to compare my numbers to hers (as she’s female). I don’t know if I’m comparing correctly. If it helps, I’m 45 🙂. Either way, really appreciate that you share your data 🙏
Richard - enjoy you videos and maybe I missed it but do you also take Metformin or Berberine? Neither is in your list of supplements. Thanks
GOOD JOB RICHARD...
Hi Kios, thank you for your supportive comment!
Thank you very much.
You are an inspiration for many people.
Thanks for making this video! Your results are very interesting. Based on your data, it seems that the powder/capsule form was better than the sublingual, but your wife's results show that there was no difference whether ingested in powder/capsule form vs sublingual. Is this correct, or did I misread your results. I'm taking NMN and have heard different views on how to take it so I ingest some with olive oil and I take some sublingually.
Thank you for the update Richard. Happy new year for you and your wife : )
Hi Zizaco. Thanks for your comment and Happy new year to you too!
Richard, the NMN process is logically a long term winding back of clock: widespread across body cells and progressive within a given cell. However, you have also experienced short term reactions: your resumption of napping when your supplies ran out; realtime influence on menstration. Do you have any explanation for this? For my own part, I am in my second week, but right from start, I have felt energised - this is also pretty immediate. At six months, you reported you were delighted with so much progress. I was delighted within 24 hours - trying to get my head around this apparent dual speed impact.
You also pointed out immediacy of your wife's puzzle scores to NMN. On other hand, David Sinclair's dad rang David after 6 months to report on noticeable change........
Thank you for your videos! Love your channel! Just a quick question: Is it better to take NMN every second day instead of daily?
Hi Tony, Thanks for your question. I don't believe so, I certainly take it daily and as the aim is to boost my NAD levels I think that makes sense.
I have heard on one of Dr. Sinclair's podcasts how he fed his mice resveratrol every other day, which seemed to have a better effect (however I was not sure this was because the mice were doing intermittent fasting or because the resveratrol was given to them on alternate days)
@@ModernHealthspan Thank you for taking the time to answer my question, Richard. You hit my point about when Dr Sinclair fed his mice Resveratrol every other day 👏🏼 very smart!
At what age you think I should consider taking NMN? (I am 41 years old)
@@tonymrad0019 Hi Tony, thanks for the question. NAD continues to go down as you age and by 50 you have half the levels of your youth. You can see here www.researchgate.net/figure/Correlation-between-NAD-levels-and-Age-in-A-Males-B-Females-A-NAD-concentrations_fig8_230590378 that the decline is gradual over time and so is probably happening when you are 41.