Can we edit the epigenome?
ฝัง
- เผยแพร่เมื่อ 3 ส.ค. 2024
- So you've likely heard of gene editing using approaches such as CRISPR-Cas9, but have you heard that we can also edit the epigenome?
In this video we'll discuss epigenetics and why this might be something you want to target (e.g to treat different diseases such as cancer & aging) and then look at how this can be achieved by modifying epigenetic marks such as methylation and acetylation.
So we can edit the epigenome, BUT there are many challenges ahead e.g delivery and designing the technology to achieve the desired outcome, but i think the tech is SUPER cool and something worth knowing about.
p.s whilst making this video i underestimated how much i could simplify it...this topic is HUGE.. so i will likely make a secondary video to explore this topic further when i get the time :D
TIMESTAMPS;
Intro - 00:00
Epigenetics - 00:40
Epigenome editing - 03:25
Challenges - 09:20
REFERENCES;
CRISPR Tools for Physiology and Cell State Changes doi.org/10.1152/physrev.00034...
Dominguez, A., Lim, W. & Qi, L. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol 17, 5-15 (2016). doi.org/10.1038/nrm.2015.2
Check out @LifeXtenShow latest video - • How Organoids Might Re...
Icons in intro; "www.freepik.com/free-photos-v..."Background vector created by freepik - www.freepik.com - วิทยาศาสตร์และเทคโนโลยี
Who can guess what I was saying at 06:00 ? Whoops, my audio got corrupted but i tried to fix where possible so hopefully not too big a problem!! :D Plus, i feel like we've only scratched the surface with this topic so hope to explore further
Please do!
you said epigenome editing :)
You watch these videos and you're like "Damn, this is so in-depth--this rules!" --But then you realize that these are coming out WEEKLY. WITH NO LOSS OF CLARITY OR DEPTH. Absolutely unreal. The research rabbit-holes made by the Sheeky Science Show are the glue that holds the whole online bioverse together. All roads lead to sheeky.
Lol, thank you!! 😊
Terrific video! Thanks! This epigenetic editing is so interesting and exciting. Before your interview, I thought the only epigenetic intervention was Yamanaka-style whole epigenome modifications. This precision editing gives us so much greater control over the expression of genes. I was starting to imagine we could just figure out the epigenome of young, healthy people and simply edit our old epigenome right back to youthful healthiness. But, after watching this video, I realize that is still well beyond the capabilities of the current editing techniques. But, who knows, maybe it will come sooner than I think. Technology is exponential after all. Once again, thanks for bringing this to our attention and explaining it (and illustrating it) so well!
I love your videos! The epigenome is not discussed enough in college genetic courses. I found this very helpful.
Superh! A new video!
I enjoy MANY TH-cam videos and your SHEEKEY SCIENCE videos are a 10 on a scale of 1-10. These should be required viewing in all schools worldwide to make science interesting, fun and understandable.Thank You for all you do and may you "Live long and prosper" :-)
Great video and a decent explanation of the issues. Not sure we should do something because we can as it is clear we dont clearly understand the unintended consequences.
Nice video, dCAS9 i never heard of that... i am happy that i learnt something new and interesting today :)
Love your videos! Thank you!!
Another great video! Thank you!
so amazing! thanks!
Have you read the pre-read of the last study of Horvath? He claims to have discovered the places along the DNA where the methylation is causing the aging of the body. If we can change the methylation precisely in the close future...that would be game changing!
Do we have the capability to do an epigenetic sequencing of all main organ cells? At least people might might be able to catalogue how their cells used to express themselves when they were healthy, before age/disease.
Awesome video. I'd guess that as of now, scientists have not yet mapped out different epigenetic markers to their functions. If you think about it - the real problem is all about the mapping. Once the scientists have the mapping, they can edit the epigenetic markers to produce a particular effect.
Would it require something similar to 90's genome sequencing effort?
@@kral3046 I'd guess so. "Sequencing" epigenetic markers probably won't be enough though. Mapping their functions probably would be far more difficult.
Thanks! Multiple rabbit holes, one of which I will go back to and research. But off the top of my head, I recall that some of the non-coding DNA, what might have been termed Junk DNA in the past, has regulatory functions. So, does non-coding DNA affect gene expression in a way the overlaps or complements the epigenome maintenance/marking systems? Not even sure the question makes sense.
Yes, exactly, non-coding sequences contain binding sites for different proteins involved in gene expression! So is definitely bidirectional relationship
Liked it even before watching 😂❤
Wondering what your view was on the latest research into NR and NMM in 2021 presented in this video by Dr Brad Stanfield “Why I’ve STOPPED Taking NMN”
Australia?
Hey would you be able to find someone who can dub these in Spanish or do Spanish subtitles? If not maybe I can try but I dunno. Might be easier if you already had these written in English before you made them and just run them through Google translate. (Edit: Nevermind I just saw the subtitles in english are auto generated pretty well, maybe there’s an easy way to convert to Spanish.)
Could you make a video on CrisorOFF
Actually just made one on CRISPRa /i, but haven't actually read crispr-off study yet!! th-cam.com/video/H-szjgeEuoM/w-d-xo.html
Prior to cell division the DNA is copied. But how is methylation and acetylation copied? What is the machinery?
Good question, there are proteins that have been discovered that can can copy marks across during replication but it has been very challenging to study this precisely
Gee!
What is the practical application in your expectations? Can you change a red skin into a brown skin? How about changing hair color (permanently). Maybe an old rat into a young rat?
A lack in expression of certain enzymes can cause all sorts of problems. Lactose intolerance is simply a lack in expression of an enzyme that breaks down lactose. Many issues that people face everyday are results of over or under expression of certain enzymes. Also potentially aging, depression, anxiety. All the neurotransmitters are regulated by gene expression, I cant even imagine how far we could go with understanding epigenetics.
could editing the epigenetic be able to change a persons sexual orientation? im asexual and really wish i wasnt and am hopeping this cure cure asexuality.
you lost me at hello. you are very brilliant, but you need to dumb it down a little. kisses
LSD1 is better for us than LSD.
💙💛❤