@@beautyofsalvationinchristif by God you mean millions and millions of years of evolution then .. still no because nothing in biology is "perfect", starting from the most important process - photosynthesis with it's promiscuous and ineffective Rubisco through incredible amount of trash we accumulated in our genome, some of which serve no other purpose (that we know of) other than causing disease ending with "surprises" like indestructible proteins that can cause other proteins to deform. So much evidence for evolution - that if anything makes the world and our existence more beautiful and special,not less - that for any sane person it's impossible to deny. Want to praise your imaginary sky daddy, go ahead - but kindly take your delusional bullshit to suitable space which is away from science oriented spaces.
You just made the best video about replication on all of TH-cam. The depth of a university lecture with the visual quality of WEHI and the friendly didactic refinement of Ninja Nerd. Replication made me fall in love with Biology (and teaching). It seemed so complex and random at first, but I challenged myself to teach it on a video trying to make it make sense (so it could be understood, and not just memorized), and then I discovered that everything has a reason in Biology. I'm very happy that someone who feels like a soulmate in regards to the passion for teaching science also has the modelling and animation skills and motivation to make these videos. So glad you're back and better than ever.
It's the same thing that happened to me--I was annoyed that my college made me take their bio-101 course after I got a 5 on the AP Bio exam. I was sitting there--equal parts tired and annoyed and smug some late September day when my professor casually jumped from the syllabus and explained the binding curve for hemoglobin. It all just suddenly snapped into focus for me. I wasn't in the business of beating tests and memorizing facts--I was in the process of uncovering an astonishing network of mechanisms and feedback loops. Completely transformative. Love meeting a fellow traveler. Thank you for taking the time to write. It is such a deep wellspring of joy to hear from folks who've put in the work to make this discipline more accessible. Hope you're well.
The name change is so right, because so many times i tried to look this channel up and could never remember if it was This Elegant Mechanism, or Our Beautiful Vehicles or what
God calls Himself "I Am' in the Bible. He is the One who created the protein machines and the code all at the same time otherwise replication would not have been possible. Great video to showcase His immeasurable intelligence!
After reading about the Hidden DNA Potential on shirlest, I felt an incredible shift in my mindset. It’s like unlocking a superpower within myself. Everyone should explore this.
That means everything to me! I've got part 2 about transcription in eukaryotes coming out in about two more weeks. Let me know if there's any other topics that your students typically get stuck on that could use a little more visualization!
@@Clockworkbio Thank you! I seriously struggle to find videos that can accurately describe the processes without "dumbing down" the material too much and making it childish, or without presenting the material at a college level. I know I'd really appreciate a video on cellular respiration (especially the electron transport chain).
Once I'm finished hacking away at the central dogma -- I'm tackling the cell cycle and respiration as my 'core topics.' Mitosis probably won't get done until the start of the next academic year, but I'll chip away at it as fast as I can!
@@DraigBlackCatI would highly recommend getting a chrome extension or something similar to give yourself a more nuanced control over playback speed on TH-cam. I often use TH-cam videos to practice music and to have control down to individual percentage points is indispensable. Not applicable on iPhone but 🤷♂️
This way of learning about replication is so much more fun than what I had available, which was sitting in a cold lecture theater, watching other students go online shopping than learn about DNA polymerase
to be fair tho--all this really can be is a gateway for that style of learning. You still need that lecture setting and (if possible) to take advantage of office hours so your prof or a TA can make that weird crab-claw shape with their hand and explain exactly how polymerases grab onto ssDNA.
@@Clockworkbio That's true. As unpleasant as that lecture hall was, it was a great setting for learning. Plus my prof used Play Doh for the ribosome subunit section, so I can't really complain too much.
I'M SOO GLAD U CAME BACK UR VIDEOS ARE AN HONOUR TO WATCH FOR FREE..... U ARE BOUND TO GROW......JUST BE CONSISTENT AND NEVER LOOSE HOPE...AND REMEMBER I WILL ALWAYS BE A FAN OF UR CHANNEL
Believe in One God. God don't eat or drink He is not born nor He tastes death and there is nothing like Him. It is idolatry worshipping created things over Creator.
I absolutely adore your storytelling. THIS is how biology should be taught - as a medium for profound explanation of nearly everything we take for granted yet underlying incredibly interesting phenomena, inspiring curiosity and awe! Please keep going!!
Eh, personally I think there's a lot more to tighten up before we start talking about those numbers. Happy that you're here though! Excited to keep improving with every video.
One thing I am a bit surprised you didn't mention is the proofreading ability of the polymerases. Both polymerase ε and δ have the ability to recognize incorrect bases that were mistakenly incorporated (which does rarely happen), move the DNA over to an exonuclease site to remove the incorrect base and then continue with replication. This improves the accuracy by a factor of something like 100-1000x!
Yea-I started this video with a borderline unhinged 30 minute draft that talked about the exonuclease domains and the fact that POLA doesn’t have one. But I decided to split the error correction parts off into their own video. Replication first-then we talk about fixing replication errors (and how there can STILL be mutations somehow) and then we FINALLY make it all the way into the central dogma. It’s only going to take six months (lol) but I think it’s a good structure. Sets us up nice to explore a very high level introduction to epigenetics after that. Crime I couldn’t even fit in any of the clamp loaders or DNA ligaments in here.
@Clockworkbio might be an idea to mention any such mechanisms you are passing over, especially if you plan on covering them in a separate video. Otherwise biochem newbies might assume that this was the complete story.
I found this channel senior year of high school when I was trying to decide my major. These videos inspired to choose biochemistry and now I finished biochem 2 last semester, have been working full time in a biochem research lab this summer, and am working on grad school apps to submit this fall. Here’s to all that’s still out there to learn and here’s to you for these incredible videos!
I learned this process with topoisomerase, DNA-Polymerase 1,3,5 and the SSBPs, maybe i missed them but i didnt see them, since i learned after the helicase splits your DNA, the SSBP hold them appart so they dont get back together. Also i learned about the DNA-Ligase, removing the Primers, maybe ive missed them but didnt see them. Anyways, very good explination, and very good video, very enjoyable!
An amazing video as always. I just thought perhaps you should have spoken a bit more about DNA ligase, DNA topoisomerase, Okazaki fragments and the verifier DNA polymerase(forgot its actual name), as these are processors at the same level of complexity as those mentioned in the video.
I absolutely love that you have pointed out that the trillions of actions of replication happening in me right now, have been pretty much doing that for billions of years. Excellent stuff.
Love the channel and the new season. It would be very helpful if you would remind the audience what chemistry is taking place. Especially during the mechanical movement of each (or even some) of the 3D renderings. Even just a short breakdown of what squiggly green, or ATGC molecules are made of atomically. I know this is a molecular biology channel, but the visuals still just seem so abstract. A brief summary with accompanying diagram of the atomic structure of the titular molecules would clear up a lot of the confusion. Sorry if it’s just me, nuke physics here, basic chemistry is my most basic form of communication with you molecbios
One big next step for me is slowly getting into more MD Analysis for very specific and small segments of future videos. I think this video would have benefitted SO MUCH if I'd had the time and skill to zoom all the way in and show just one phosphodiester forming. I'll probably add one as a one-off or short in the future. I cannot express enough how important feedback like this is to me. It's essential to put in the effort to make these videos as valuable an educational tool as possible. Comments like yours are a critical signal that help me increment and iterate further. Thank you so much!
My favorite part about teaching this is to bring up what I call the 'Eukaryote problem' of DNA replication always has to start from something (DNA or RNA) so how does a Eukaryote with chromosomes deal with this. After bringing up that plasmids are circular so this isn't a problem I can usually lead my class into describing telomers
Just use these to remind yourself that there isn't a single second of med school that's actually boring. It can just be tedious when you're speed-running thousands of years of collected knowledge in preparation for your long war against pain and pathology. Every detail has life and death implications down the line. The furthest thing from boring.
The way that Pol D puts the lagging strand together in such tiny snippets(when compared to the length of a chromosome) all the way over there just blows my mind. It has real “pay no attention to the man behind the curtain” energy.
I’m so happy you’re back at it! I came across your channel a few months ago, and I was disappointed when it had been 3 years since the last episode. The way you explain things adds a deeply knowledgeable and poetic energy to life’s story. I can’t wait to see more!
What a wonderful video! It's only one step away from seeing it all as quantum processes and EVERYTHING just being in complete flow. I don't think about the names of the objects, just the shapes of their outer charges.
I am so in love with your videos, the narration and accuracy. This is a master-level lecture broken down and visualised into something that's a pleasure to watch. I was teaching hearing and brainstem response to medical students in a practical course, and I could see how their eyes really showed this "ahhhh that's how it works!" Moment. Good scientific illustration is beyond valuable - seeing is believing and understanding after all Thank you for keeping this up! I'd love to see some neurophysiology in the future (channel gating and such stuff)
The TH-cam algorithm nailed it for once! Awesome video! Honestly, this is the main reason that I plan on having kids. I’m not religious, and for me the meaning of life is keeping these little proteins fed. That’s what gave me everything I have. Why would I want to break the chain that gave me all I have?
This is truly incredible, I am so excited for this season. I just got a degree in biochemistry & molecular biology, and I think your videos are fantastic and represent the beauty of molecular life wonderfully. I really appreciate the effort you've put into your videos. Super excited for the rest of season 2!
OH WOW video after 3 years?! Welcome back and thank you! I love the quality videos you've made in the past, this one is awesome. This is a huge upgrade from the DNA Secret of Life animations I saw as a teenager learning about DNA/Mitosis for the first time.
Greetings and well done. I love your animation style here. I teach IB Biology and am always on the lookout for ... THIS ... where it's informative but mainly great visual content. I can do the teaching, but I want the students to be able to SEE the unseeable, and this makes it really approachable because the molecules just look so darn cool. Great job, keep it up, this one is going into my slide deck! Thanks!
OMGGG i opened this channel again cuz i was watching the nitrogen fixing video AND THERE S NEW VIDD?? AND ITS 3D?? i recognize those shapes! you used that addon! 3 years for learning blender is so worth it. almost like biochem bill wurtz lol
Bro I'm so happy to see one of your videos again, you are genuinely one of the major reasons I am off to university to do biochemistry in september. Thank you for helping me to find a subject l am so genuinely interested in. I hope l can count on seeing more of your videos throughout my course, keep it up bro :)
I actually teared up watching this video. Thank you so much for this. It's so fucking fascinating how these little machines work. Your excitement and wonder is very contagious. Life is so amazing.❤
Still probably going to mix in some old-school 2d for certain views of really complex structures. Not satisfied with how some of the 3d renders weren't as clear as I wanted them to be. We'll keep pushing further!
Found the channel a few months ago, got absolutely hooked and was gutted to see you’d stopped uploading. Now that you’re back, gonna do whatever it takes to keep it that way
Same, and that seems to be a lot of people's experience, I wonder why TH-cam suddenly started pushing it years after they stopped uploading. Glad it happened, but curious nonetheless.
I think we're in a science renaissance on TH-cam. A lot of great channels suddenly getting a much bigger push. Definitely feels like Im not fighting the wind anymore.
@@Clockworkbio Another person here who found the channel a few months ago in my recommendations. And I'm so glad I did- not only because your videos are absolutely incredible, but also because it meant I didn't have to wait three years hahahaha
What a great video! Given the complexity of the molecular machinery required for replication it is astounding that complex life ever got started. Evolutionary processes seem trivial compared to the bootstrapping required to initiate life.
I did not know you weren’t posting videos. I subscribe because i found two of your videos fascinating during the semester. This series lookk amazing. I do not fell confotable watching it for free. I am planning in becoming a Patron. It is just such unbelievable work.
I stumbled on your channel a few weeks ago and subscribed hoping that you'd eventually start making videos again. Thanks for coming back, this was great.
Thank you so much for making this. It's so beautiful and you made it so easy to understand, even at this shallow level, i feel like don't deserve to get this much information from a video. You are amazing, I appreciate how much work you put into this.
So immensely thankful you've started making videos again and have somehow gotten even better moving to 3D 🙏 I remember not too long ago seeing this channel in my subscriptions and remembering how great your videos were and how I wished it had worked out long term. I've watched a handful of videos on this topic and this was the best by a large margin. I never quite understood why the lagging strand had to be replicated in chunks until you explained that DNA can only be built in one direction. Nor did I realize bases other than Adenosine had triphosphate forms and their binding contibuted energy to the replisome like ATP does elsewhere. Truly some beautiful biomolecular clockwork and I quite liked your framing at the end that our DNA is the latest iteration of an unending and nearly 4 billion year old story. Ngl the bit about the "little chemical mantra" got me unexpectedly emotional 🥹 Welcome back and cheers to as many more brilliant videos like this as you're able to make at whatever pace is sustainable for you. ETA: if you see this, is it true that patreon takes a smaller cut of membership fees than YT? I see you have the prices of the amino tier set seemingly to account for that but is it a perfect match or do you end up with more from one or the other?
Glad to see you back. It's great to see this presented this way, I remember discussing this with my Dad a long time ago. Dead things don't replicate, so there's an unbroken chain for what may as well be eternity back to the first replication in every one of us.
Great video. Just started a class and it was really difficult getting the hang of replication until I saw this video and could see in 3D exactly how it works. When I tried reading on google too many of the explanations were oversimplifications that didn't make sense, but this video made it really easy to understand. Very cool.
We are so back.
So you will post videos again more frequently?
I've been waiting for it for years.
HELL YEAHHH
th-cam.com/video/zc4oEDK1qU8/w-d-xo.htmlsi=IoR7xONjcaItHszq
🎉🎉🎉
him :"I'd like to make more frequent videos"
him: *dissapears for 3 years*
Oh no I actually did become my dad after all
@@Clockworkbio Poor Clockwork 😢
😂😂
@@Clockworkbio So you are applying what you learned in the biology field ? Replicating DNA and all that stuff...
@@beautyofsalvationinchristif by God you mean millions and millions of years of evolution then .. still no because nothing in biology is "perfect", starting from the most important process - photosynthesis with it's promiscuous and ineffective Rubisco through incredible amount of trash we accumulated in our genome, some of which serve no other purpose (that we know of) other than causing disease ending with "surprises" like indestructible proteins that can cause other proteins to deform. So much evidence for evolution - that if anything makes the world and our existence more beautiful and special,not less - that for any sane person it's impossible to deny. Want to praise your imaginary sky daddy, go ahead - but kindly take your delusional bullshit to suitable space which is away from science oriented spaces.
Nice, I found this channel a couple of months ago and was sad to see all videos were years old, but here it is. Great timing
actually jealous lol.
@@ClockworkbioThis is the first of your videos I've seen! 😮 I'm already super stoked you're back lol 😅
Lol same
You just made the best video about replication on all of TH-cam. The depth of a university lecture with the visual quality of WEHI and the friendly didactic refinement of Ninja Nerd.
Replication made me fall in love with Biology (and teaching). It seemed so complex and random at first, but I challenged myself to teach it on a video trying to make it make sense (so it could be understood, and not just memorized), and then I discovered that everything has a reason in Biology. I'm very happy that someone who feels like a soulmate in regards to the passion for teaching science also has the modelling and animation skills and motivation to make these videos. So glad you're back and better than ever.
It's the same thing that happened to me--I was annoyed that my college made me take their bio-101 course after I got a 5 on the AP Bio exam. I was sitting there--equal parts tired and annoyed and smug some late September day when my professor casually jumped from the syllabus and explained the binding curve for hemoglobin. It all just suddenly snapped into focus for me. I wasn't in the business of beating tests and memorizing facts--I was in the process of uncovering an astonishing network of mechanisms and feedback loops. Completely transformative. Love meeting a fellow traveler.
Thank you for taking the time to write. It is such a deep wellspring of joy to hear from folks who've put in the work to make this discipline more accessible. Hope you're well.
This channel is gonna blow the fuck up. There are a lot of people that need this level of biochem
The name change is so right, because so many times i tried to look this channel up and could never remember if it was This Elegant Mechanism, or Our Beautiful Vehicles or what
"Clockwork" might get lost in the search though, a whole bunch of other stuff will come up
@@whatabouttheearth true true, but III will always remember
~
When you stopped making videos I was so sad.
Thanks for making thease!!!!
And I hope it works out better for you this time around!!
14:09 that sentence was so beautiful, it brought tears to my eye. I promise you my cells, i am and i wont let you down
This comment meant the world to me. Thank you so much.
God calls Himself "I Am' in the Bible. He is the One who created the protein machines and the code all at the same time otherwise replication would not have been possible. Great video to showcase His immeasurable intelligence!
After reading about the Hidden DNA Potential on shirlest, I felt an incredible shift in my mindset. It’s like unlocking a superpower within myself. Everyone should explore this.
I agree
Thank you
thanks
Thank you so much
Thank you so much
This is the best video on DNA replication I've ever seen! My high school students loved it.
That means everything to me! I've got part 2 about transcription in eukaryotes coming out in about two more weeks. Let me know if there's any other topics that your students typically get stuck on that could use a little more visualization!
@@Clockworkbio Thank you! I seriously struggle to find videos that can accurately describe the processes without "dumbing down" the material too much and making it childish, or without presenting the material at a college level. I know I'd really appreciate a video on cellular respiration (especially the electron transport chain).
@@Clockworkbio Also! A video on mitosis and meiosis would be amazing!
Once I'm finished hacking away at the central dogma -- I'm tackling the cell cycle and respiration as my 'core topics.' Mitosis probably won't get done until the start of the next academic year, but I'll chip away at it as fast as I can!
I love the new concept, I just had to watch the video at 0.75 speed as it was a lot of complex information very fast
Me too. Wish YTube had a better playback speed control because at 0.75 the audio was a little painful. 0.8 - 0.85 would be about perfect.
I had to replay a few bits myself!
@@DraigBlackCatI would highly recommend getting a chrome extension or something similar to give yourself a more nuanced control over playback speed on TH-cam. I often use TH-cam videos to practice music and to have control down to individual percentage points is indispensable.
Not applicable on iPhone but 🤷♂️
🤨😂
@@DraigBlackCatyall ready apparently
This way of learning about replication is so much more fun than what I had available, which was sitting in a cold lecture theater, watching other students go online shopping than learn about DNA polymerase
to be fair tho--all this really can be is a gateway for that style of learning. You still need that lecture setting and (if possible) to take advantage of office hours so your prof or a TA can make that weird crab-claw shape with their hand and explain exactly how polymerases grab onto ssDNA.
@@Clockworkbio That's true. As unpleasant as that lecture hall was, it was a great setting for learning. Plus my prof used Play Doh for the ribosome subunit section, so I can't really complain too much.
I can't get over these visuals! Such a better way to see these tiny machines.
I'M SOO GLAD U CAME BACK UR VIDEOS ARE AN HONOUR TO WATCH FOR FREE..... U ARE BOUND TO GROW......JUST BE CONSISTENT AND NEVER LOOSE HOPE...AND REMEMBER I WILL ALWAYS BE A FAN OF UR CHANNEL
I don't know why, but the nucleotide just face-planting and falling at 8:52 got a chuckle out of me XD
Believe in One God. God don't eat or drink He is not born nor He tastes death and there is nothing like Him. It is idolatry worshipping created things over Creator.
@@qasimalmani647jesus christ bro can you stop forcing your religion on people and ruining comment sections
We need more content creators like this in the field of biology
I absolutely adore your storytelling. THIS is how biology should be taught - as a medium for profound explanation of nearly everything we take for granted yet underlying incredibly interesting phenomena, inspiring curiosity and awe! Please keep going!!
Finally found another underrated science channel with production quality of 500k channel❤
Eh, personally I think there's a lot more to tighten up before we start talking about those numbers. Happy that you're here though! Excited to keep improving with every video.
One thing I am a bit surprised you didn't mention is the proofreading ability of the polymerases. Both polymerase ε and δ have the ability to recognize incorrect bases that were mistakenly incorporated (which does rarely happen), move the DNA over to an exonuclease site to remove the incorrect base and then continue with replication. This improves the accuracy by a factor of something like 100-1000x!
Yea-I started this video with a borderline unhinged 30 minute draft that talked about the exonuclease domains and the fact that POLA doesn’t have one. But I decided to split the error correction parts off into their own video. Replication first-then we talk about fixing replication errors (and how there can STILL be mutations somehow) and then we FINALLY make it all the way into the central dogma.
It’s only going to take six months (lol) but I think it’s a good structure. Sets us up nice to explore a very high level introduction to epigenetics after that. Crime I couldn’t even fit in any of the clamp loaders or DNA ligaments in here.
@Clockworkbio might be an idea to mention any such mechanisms you are passing over, especially if you plan on covering them in a separate video. Otherwise biochem newbies might assume that this was the complete story.
I found this channel senior year of high school when I was trying to decide my major. These videos inspired to choose biochemistry and now I finished biochem 2 last semester, have been working full time in a biochem research lab this summer, and am working on grad school apps to submit this fall. Here’s to all that’s still out there to learn and here’s to you for these incredible videos!
This means the world to me. Hard to fit it all into words alone.
Keep going and DFTBA.
don't forget that this replication doesn't happen just in the nucleous but also in the mitochondria because they have their own DNA
And their replication is exactly just like in bacteria.
I learned this process with topoisomerase, DNA-Polymerase 1,3,5 and the SSBPs, maybe i missed them but i didnt see them, since i learned after the helicase splits your DNA, the SSBP hold them appart so they dont get back together. Also i learned about the DNA-Ligase, removing the Primers, maybe ive missed them but didnt see them. Anyways, very good explination, and very good video, very enjoyable!
Omg…what amazing graphics and crisp narration! Bravo and THANK YOU!
It feels illegal to watch all your videos for free
Why?
@@desmond3828 Because they're SO GOOD. Videos that accompany textbook purchases don't even come close to touching the quality and detail.
Knowledge should be available for everyone.
@@UnluckySlava prescicely!
@@UnluckySlava it should!
An amazing video as always. I just thought perhaps you should have spoken a bit more about DNA ligase, DNA topoisomerase, Okazaki fragments and the verifier DNA polymerase(forgot its actual name), as these are processors at the same level of complexity as those mentioned in the video.
yes I hope he does something on topoisomerase.
I absolutely love that you have pointed out that the trillions of actions of replication happening in me right now, have been pretty much doing that for billions of years. Excellent stuff.
Oh my god these animations are incredible, love how it feels like claymation. Excited to have found your channel!
Love the channel and the new season. It would be very helpful if you would remind the audience what chemistry is taking place. Especially during the mechanical movement of each (or even some) of the 3D renderings. Even just a short breakdown of what squiggly green, or ATGC molecules are made of atomically. I know this is a molecular biology channel, but the visuals still just seem so abstract. A brief summary with accompanying diagram of the atomic structure of the titular molecules would clear up a lot of the confusion. Sorry if it’s just me, nuke physics here, basic chemistry is my most basic form of communication with you molecbios
One big next step for me is slowly getting into more MD Analysis for very specific and small segments of future videos. I think this video would have benefitted SO MUCH if I'd had the time and skill to zoom all the way in and show just one phosphodiester forming. I'll probably add one as a one-off or short in the future.
I cannot express enough how important feedback like this is to me. It's essential to put in the effort to make these videos as valuable an educational tool as possible. Comments like yours are a critical signal that help me increment and iterate further. Thank you so much!
Life Just Works and you just educate and share. So good to have you back.
The legend returns!
My favorite part about teaching this is to bring up what I call the 'Eukaryote problem' of DNA replication always has to start from something (DNA or RNA) so how does a Eukaryote with chromosomes deal with this. After bringing up that plasmids are circular so this isn't a problem I can usually lead my class into describing telomers
Should be watching these instead of boring lectures at med school, it’s just inspirational, thanks
Just use these to remind yourself that there isn't a single second of med school that's actually boring. It can just be tedious when you're speed-running thousands of years of collected knowledge in preparation for your long war against pain and pathology.
Every detail has life and death implications down the line. The furthest thing from boring.
you returned after 3 years and dropped this banger out of nowhere, welcome back my man!
The most detailed and incredible molecular biology videos I have ever seen come from this channel. Thanks for being so awesome clockwork! 😄
Return of Clockwork before GTA6!
😆
The way that Pol D puts the lagging strand together in such tiny snippets(when compared to the length of a chromosome) all the way over there just blows my mind. It has real “pay no attention to the man behind the curtain” energy.
It's all sweat shops I tell ya....young proteins operating heavy equipment...
I’m so happy you’re back at it! I came across your channel a few months ago, and I was disappointed when it had been 3 years since the last episode. The way you explain things adds a deeply knowledgeable and poetic energy to life’s story. I can’t wait to see more!
What a wonderful video! It's only one step away from seeing it all as quantum processes and EVERYTHING just being in complete flow. I don't think about the names of the objects, just the shapes of their outer charges.
This is an amazing achievement of illustration, explanation and inspiration. Beautiful.
The process seems too unbelievably complicated and intricate to have started naturally, and yet it apparently did. Thanks the details and visuals.
Nobody ever told this story in this understandable way. Thanks for coming back!
stunning work. got me a little misty eyed near the end there thinking about the immensity of it all
DNA replication researcher here! Love this video so much, can you do one on the replication stress response, and the three human PI3 Kinases?
I love your sense of humour and the way you explain how amazing life truly is ❤
I came across this channel a few months ago and subscribed for this moment even though you hadn't uploaded in ages. Worth it.
I am so in love with your videos, the narration and accuracy. This is a master-level lecture broken down and visualised into something that's a pleasure to watch.
I was teaching hearing and brainstem response to medical students in a practical course, and I could see how their eyes really showed this "ahhhh that's how it works!" Moment. Good scientific illustration is beyond valuable - seeing is believing and understanding after all
Thank you for keeping this up! I'd love to see some neurophysiology in the future (channel gating and such stuff)
The TH-cam algorithm nailed it for once! Awesome video!
Honestly, this is the main reason that I plan on having kids. I’m not religious, and for me the meaning of life is keeping these little proteins fed. That’s what gave me everything I have. Why would I want to break the chain that gave me all I have?
This is truly incredible, I am so excited for this season. I just got a degree in biochemistry & molecular biology, and I think your videos are fantastic and represent the beauty of molecular life wonderfully. I really appreciate the effort you've put into your videos. Super excited for the rest of season 2!
Amazing animation, details and narration. I’m glad you’re back!
Would not mimd longer videos that go in to more detail as well.
Glad to see this channel alive, so mamy good videos.
OH WOW video after 3 years?!
Welcome back and thank you!
I love the quality videos you've made in the past, this one is awesome. This is a huge upgrade from the DNA Secret of Life animations I saw as a teenager learning about DNA/Mitosis for the first time.
Greetings and well done. I love your animation style here. I teach IB Biology and am always on the lookout for ... THIS ... where it's informative but mainly great visual content. I can do the teaching, but I want the students to be able to SEE the unseeable, and this makes it really approachable because the molecules just look so darn cool. Great job, keep it up, this one is going into my slide deck! Thanks!
I discovered this channel just a few days ago & the new season is already starting. I guess it really is like clockwork
Life is like that. Sometimes luck is just as important a factor as anything else. Glad you're here for this era!
Awesome video, great refresher as it's been a minute since I studied all this. The animations are really helpful. Looking forward to more!
OMGGG i opened this channel again cuz i was watching the nitrogen fixing video AND THERE S NEW VIDD?? AND ITS 3D?? i recognize those shapes! you used that addon! 3 years for learning blender is so worth it. almost like biochem bill wurtz lol
Great timing, I just started binge watching your videos the other day.
one of the coolest channels ive come across period
Algorithm is shifting. A lot of high effort folks beginning to break out. Really cool time to explore the home page. Thanks for being here early!
It is so cool having you back, I hope you keep uploading videos here, this comunity loves you!!!
Bro I'm so happy to see one of your videos again, you are genuinely one of the major reasons I am off to university to do biochemistry in september. Thank you for helping me to find a subject l am so genuinely interested in. I hope l can count on seeing more of your videos throughout my course, keep it up bro :)
I actually teared up watching this video. Thank you so much for this. It's so fucking fascinating how these little machines work. Your excitement and wonder is very contagious. Life is so amazing.❤
Man, what a great video. CGI is such an incredibly effective teaching tool for stuff like this!
Still probably going to mix in some old-school 2d for certain views of really complex structures. Not satisfied with how some of the 3d renders weren't as clear as I wanted them to be. We'll keep pushing further!
absolutely incredible work CW! Truly great work, you should be very proud!
AMAZING CONTENT ❤❤
Found the channel a few months ago, got absolutely hooked and was gutted to see you’d stopped uploading. Now that you’re back, gonna do whatever it takes to keep it that way
Same, and that seems to be a lot of people's experience, I wonder why TH-cam suddenly started pushing it years after they stopped uploading. Glad it happened, but curious nonetheless.
I think we're in a science renaissance on TH-cam. A lot of great channels suddenly getting a much bigger push. Definitely feels like Im not fighting the wind anymore.
@@Clockworkbio Another person here who found the channel a few months ago in my recommendations. And I'm so glad I did- not only because your videos are absolutely incredible, but also because it meant I didn't have to wait three years hahahaha
oh man my day just got better! glad you've started up again. And the 3D animations are great!
What a great video! Given the complexity of the molecular machinery required for replication it is astounding that complex life ever got started. Evolutionary processes seem trivial compared to the bootstrapping required to initiate life.
I did not know you weren’t posting videos. I subscribe because i found two of your videos fascinating during the semester. This series lookk amazing. I do not fell confotable watching it for free. I am planning in becoming a Patron.
It is just such unbelievable work.
Thanks for a great video! I am going to have to watch it several times to fully appreciate it.
Your channel deserves a lot more success, so dont mind me boosting the alg. Gonna watch in 0.25 speed later
This video is insanely good, bro you deserve so much more, the amount of effort and tought put into a video like this is absurd.
👏👏👏👏👏👏
The work is its own reward. These things take time--but Im so happy that the work is finally getting out there!
@@Clockworkbio Awesome, You definetely deserve every bit of recognition and atention
Clockwork is back, now that's a good year
The legend has returned
Great presentation of a very interesting, difficult subject... thank you for your commitment to making compelling content
I subscribed a few months ago, because I liked your videos, not knowing if there was going to be more uploads. What a pleasant surprise
Just found your channel a month ago and I've been catching up and can't believe you're back!
Thanks for making these. Very happy you're back!
I stumbled on your channel a few weeks ago and subscribed hoping that you'd eventually start making videos again. Thanks for coming back, this was great.
Wow! I love your videos, they're better than an entire semester
Love this! I hope you can do more! This kinda stuff makes you look at the world with new magic eyes
Absolute banger material my man.
Thank you so much for making this. It's so beautiful and you made it so easy to understand, even at this shallow level, i feel like don't deserve to get this much information from a video. You are amazing, I appreciate how much work you put into this.
my favorite yt channel is back, with the best comeback ever
I just found you day before yesterday!!! And now, I'm expecting some consistency!!
So immensely thankful you've started making videos again and have somehow gotten even better moving to 3D 🙏 I remember not too long ago seeing this channel in my subscriptions and remembering how great your videos were and how I wished it had worked out long term.
I've watched a handful of videos on this topic and this was the best by a large margin. I never quite understood why the lagging strand had to be replicated in chunks until you explained that DNA can only be built in one direction. Nor did I realize bases other than Adenosine had triphosphate forms and their binding contibuted energy to the replisome like ATP does elsewhere. Truly some beautiful biomolecular clockwork and I quite liked your framing at the end that our DNA is the latest iteration of an unending and nearly 4 billion year old story. Ngl the bit about the "little chemical mantra" got me unexpectedly emotional 🥹
Welcome back and cheers to as many more brilliant videos like this as you're able to make at whatever pace is sustainable for you.
ETA: if you see this, is it true that patreon takes a smaller cut of membership fees than YT? I see you have the prices of the amino tier set seemingly to account for that but is it a perfect match or do you end up with more from one or the other?
No way! Perfect time to find your channel
Glad to see you back. It's great to see this presented this way, I remember discussing this with my Dad a long time ago. Dead things don't replicate, so there's an unbroken chain for what may as well be eternity back to the first replication in every one of us.
Oh wow. The astonishing complexity of reality, of ME, is beyond words❤
i loved the ending bit of this video so much
thank you
I did my small happy dance when I saw that you uploaded again. Thank you so much I love your content.
It baffles me that gems such as your channel don't get more attention for the scientific and artistic prowess on display, keep up the good work! 😎👍
appreciate the sentiment! Wind appears to be shifting little by little!
This blows my mind. Amazing work!
One for the algorithms, this channel is great!
3:44 I see what you're doing right here. Your video is fine tuned for seeming authoritative about these subjects!
3d or not, your videos are amazing anyway.
I love your content and am so happy to see you back.
im so glad you're back❤ love your videos
Great video. Just started a class and it was really difficult getting the hang of replication until I saw this video and could see in 3D exactly how it works. When I tried reading on google too many of the explanations were oversimplifications that didn't make sense, but this video made it really easy to understand. Very cool.
This video is very complex and philosophical.
BROOOO, so happy to see this account is back!!!!!!! I thought this was a dead channel! What an ecstatic surprise!!!
And when we form equal societies and work only through the information we share with machines we will become the DNA
Waiting for this video for years ❤