Even though DNA methylation based 'aging clock' approaches are in vogue right now, I'd love to see someone produce a method for calculating aging based on the levels of advanced glycation end products in the body, because I believe that approach is one of the keys to slowing down / reversing aging. Even exogenous AGEs were able to negate the longevity benefits of calorie restricted diet (the most studied longevity approach out there) in animal models.
Do you give one:one sessions on aging and while body health? I apologise if this sounds weird but I would appreciate a one:one chat with you! I love your content and thank you for sharing so much of what you discover... It really helps my research journey.
How does the epigenome work, is it like programs that switches between different patterns? Or is it like modules, that one place activates a certain function or gene? Whats the relationship with acetylation of histones? Cool topic.
Interesting. So interesting to approach this from a statistical point of view. I suppose that's better at the start than trying to untangle function first. I can kinda see that path. I'm sure it could lead in a huge number of directions.
Thanks for this discussion. Mind wandering: I wonder is the protein changes observed (more youthful) in the 2020 Conboy plasma exhange experiments were driven by changes in the epigenome? If so, how this might occur? Conboys saw changes after one month but did not test for longer durations.
Great! However the paper is not open access. While I'm not sure of the solution (although there are lots of attempts out there), it would be better if you could also point to some closely related material as well, for those who want to read more, but don't want to spend an exorbitant amount for one paper.
I would think that the epigenetic methyl markers would ALTER the proteins produced by the genes. And humans could easily adjust these markers. If its not that simple, why not -lol? Excuse my layman logic (LL).
If you enjoyed our conversation, check out a link to Kirsten's review in the description!
Even though DNA methylation based 'aging clock' approaches are in vogue right now, I'd love to see someone produce a method for calculating aging based on the levels of advanced glycation end products in the body, because I believe that approach is one of the keys to slowing down / reversing aging. Even exogenous AGEs were able to negate the longevity benefits of calorie restricted diet (the most studied longevity approach out there) in animal models.
Yes. Definitely need more measurables.
Plot twist: both of these ladies are in their late 60's
Fascinating and clear-eyed interview - good job!
have there been methylation measurements on children suffering from Progeria?
Brilliant question 😎👍
Do you give one:one sessions on aging and while body health? I apologise if this sounds weird but I would appreciate a one:one chat with you! I love your content and thank you for sharing so much of what you discover... It really helps my research journey.
How does the epigenome work, is it like programs that switches between different patterns? Or is it like modules, that one place activates a certain function or gene? Whats the relationship with acetylation of histones? Cool topic.
Interesting. So interesting to approach this from a statistical point of view. I suppose that's better at the start than trying to untangle function first. I can kinda see that path. I'm sure it could lead in a huge number of directions.
Hi what program do you use as a screen capture to your pc.?
Thanks for this discussion. Mind wandering: I wonder is the protein changes observed (more youthful) in the 2020 Conboy plasma exhange experiments were driven by changes in the epigenome? If so, how this might occur? Conboys saw changes after one month but did not test for longer durations.
Great! However the paper is not open access. While I'm not sure of the solution (although there are lots of attempts out there), it would be better if you could also point to some closely related material as well, for those who want to read more, but don't want to spend an exorbitant amount for one paper.
Great channel thank you
Excellent, just excellent.
Great information
Look at what The Salk Institute found when researching Acetyl-Coenzyme A!!!
I would think that the epigenetic methyl markers would ALTER the proteins produced by the genes. And humans could easily adjust these markers. If its not that simple, why not -lol? Excuse my layman logic (LL).
Unlikely to alter the proteins themselves, but potentially (depending on methylation pattern) alter their expression (quantity)
That was a lot of data. Can you do a takeaways video
awesome
🔥🔥🔥
you will straight up look like that author in 60 years i swear hahah,
Gold star lol