Obesity and Metabolic Syndrome | Clinical Medicine

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Ninja Nerds!
In this lecture, Professor Zach Murphy will present on Obesity and Metabolic Syndrome. We will discuss the pathophysiology of obesity, focusing on the imbalance between caloric intake and energy expenditure, and Metabolic Syndrome, characterized by a cluster of conditions including high blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels. The lecture will include a discussion on the clinical manifestations of both conditions, such as increased risk of cardiovascular disease, type 2 diabetes, and other health problems. The digital presentation will begin with the diagnostic approach, highlighting the criteria for Metabolic Syndrome diagnosis and the importance of body mass index (BMI) for assessing obesity. Finally, we will review management strategies for both conditions, emphasizing lifestyle modifications such as diet, exercise, and in some cases, pharmacotherapy and bariatric surgery for obesity. Enjoy the lecture and support us below!
Table of Contents:
0:00 Lab
0:07 Obesity & Metabolic Syndrome Introduction
0:42 Pathophysiology of Obesity
7:17 Metabolic Syndrome
8:28 Caloric Intake
10:18 Caloric Expenditure
12:56 Complications of Obesity & Metabolic Syndrome
30:15 Diagnostic Approach to Obesity & Metabolic Syndrome
31:13 Treatment of Obesity & Metabolic Syndrome
37:51 Comment, Like, SUBSCRIBE!
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#ninjanerd #endocrine #obesity

[@odemi2537]

Each time I am watching another lecture with Ninja Nerds, my heart fills with so much gratitude. I am sharing them with anyone I know. You are definitely a gift, Professor Zach Murphy, and of course, your entire team. I graduated a while ago, and I am still coming back to these lectures over and over.

[@agadooska]

NAFLD is now called metabolic dysfunction-associated steatotic liver disease (MASLD), I think we will need to get used to the new term soon.

[@pasindusangeeth309]

Is it also called MAFLD ?

[@mostafael-dya4916]

Thank you zach and to all your team members for this great effort.

[@hayleybrooks04]

YOU... YOU ARE THE GOD OF PHYSIOLOGY.
I'M A FAN.

[@valviv]

Great video, thanks Ninja Nerd!

[@BlndDler-zm4mu]

keep up the great work, thanks so much this helped so much no doctor in my college could explain it like you. Also love the new format for the lectures

[@peuppeuppeup]

thanks for u dedication🎉

[@AhmedKhaled-zy6er]

You are the best of the best, man !!! 💓

[@anjalimaurya_4679]

Your video are really helpful to everyone 👏👏💫💫

[@vincentcyrilliansantoso9858]

This is awesome!

[@shahiramohammadi7284]

Zach is my super ninja hero 💐💐

[@JTmoto]

Doing a literature review related to MASLD and obviously obesity, this video helped understand the concept way better. ⚕️✨

[@serenitysel]

Man the new sleeves look so cool!

[@casualonemmo-player2167]

Regarding the clogging up inside of the blood vessels... if you loose a lot of weight, and get into a normal bmi range... will most of the clogging get removed by itself? *or is that "damage" permanent?

[@brofred7623]

Благодарю вас

[@ok6109]

Thanks❤❤❤

[@eveberry9215]

thanks ninja nerd

[@TheSeahealth]

I really like your explanation, Prof. Zach, especially biochemistry and metabolism, but you have to consider another concept about obesity, namely that it starts with hyperinsulinemia due to high carbohydrates...thank you

[@TheSeahealth]

not only just calories

[@TheSeahealth]

how ketogenic diet?

[@finncsprivatechannel2215]

With regards to meds, antihistamines, especially centrally acting, are a massive cause of fat-specific weight gain and insulin resistance. Drugs like olanzapine will cause the most weight gain owing both to potent D2 and H1 antagonistic effects.

[@sajiruddinsk8129]

Allways follow to you.

[@sanjith1179]

6 th like sir, I'm pratheesh from india( tamilnadu).big fan of you sir.say one hii sir.

[@CoachSusie]

I love you

[@user-bu9mk5hd1y]

💯🥷💯🥷💯🥷💯

[@sciencesimplified3890]

I think this video should be re-made. There are different theories of the pathophysiology of metabolic syndrome. Many argue excess calories cause hypertrophic adipose tissue to undergo lipolysis, releasing Free fatty acids(FFA) into blood where it enters skeletal muscle (forming DAG which inhibit PKC which inhibit the insulin receptor) and also the high flux of FFA entering the liver up regulates VLDL secretion. The biochemistry defending this has been established in vivo in humans using NMR spectroscopy. Other evidence is the actos medication increases adipose tissues capacity to store FFA, reducing lipolysis and reducing these symptoms, also on the opposite spectrum the disease lipodystrophy reduces adipose tissue capacity to store fat, increasing lipolysis and FFAs entering blood and exacerbates these symptoms. I need to emphasize, im not saying the obesity and FFA theory is dogma, however to say the adipokines are definitively the cause I personally believe is inaccurate and should be emphasized is theoritcal

[@sheilaherrera8584]

How about you make your own video